{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:23:55Z","timestamp":1768969435223,"version":"3.49.0"},"publisher-location":"Cham","reference-count":18,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030692162","type":"print"},{"value":"9783030692179","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-69217-9_11","type":"book-chapter","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T11:06:48Z","timestamp":1625051208000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Possible Overcoming of Tumor Hypoxia with Adaptive Hypofractionated Radiosurgery of Large Brain Metastases: A Biological Modeling Study"],"prefix":"10.1007","author":[{"given":"Lijun","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Lin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Sahgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"11_CR1","doi-asserted-by":"crossref","unstructured":"Fokas E, Henzel M, Surber G, Kleinert G, Hamm K, Engenhart-Cabillic R. Stereotactic radiosurgery and fractionated stereotactic radiotherapy: comparison of efficacy and toxicity in 260 patients with brain metastases. J Neurooncol. 2012;109:91\u20138.","DOI":"10.1007\/s11060-012-0868-6"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1227\/01.NEU.0000064569.18914.DE","volume":"52","author":"T Hasegawa","year":"2003","unstructured":"Hasegawa T, Kondziolka D, Flickinger JC, Germanwala A, Lunsford LD. Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy? Neurosurgery. 2003;52:1318\u201326.","journal-title":"Neurosurgery"},{"issue":"Suppl","key":"11_CR3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3171\/2014.8.GKS141461","volume":"121","author":"I Toma-Dasu","year":"2014","unstructured":"Toma-Dasu I, Sandstr\u00f6m H, Barsoum P, Dasu A. To fractionate or not to fractionate? That is the question for the radiosurgery of hypoxic tumors. J Neurosurg. 2014;121(Suppl):110\u20135.","journal-title":"J Neurosurg"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3171\/jns.2006.104.6.907","volume":"104","author":"MA Vogelbaum","year":"2006","unstructured":"Vogelbaum MA, Angelov L, Lee SY, Li L, Barnett GH, Suh JH. Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor margin. J Neurosurg. 2006;104:907\u201312.","journal-title":"J Neurosurg"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.ijrobp.2008.10.035","volume":"74","author":"Y Higuchi","year":"2009","unstructured":"Higuchi Y, Serizawa T, Nagano O, Matsuda S, Ono J, Sato M, Iwadate Y, Saeki N. Three-staged stereotactic radiotherapy without whole brain irradiation for large metastatic brain tumors. Int J Radiat Oncol Biol Phys. 2009;74:1543\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"11_CR6","doi-asserted-by":"crossref","unstructured":"Minniti G, Scaringi C, Paolini S, Lanzetta G, Romano A, Cicone F, Osti M, Enrici RM, Esposito V. Single-fraction versus multifraction (3 \u00d7 9\u00a0Gy) stereotactic radiosurgery for large (>2\u00a0cm) brain metastases: a comparative analysis of local control and risk of radiation-induced brain necrosis. Int J Radiat Oncol Biol Phys. 2016;95:1142\u20138.","DOI":"10.1016\/j.ijrobp.2016.03.013"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","volume":"47","author":"E Shaw","year":"2000","unstructured":"Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47:291\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl\u00a01","key":"11_CR8","doi-asserted-by":"publisher","first-page":"i76","DOI":"10.1093\/jrr\/rrw015","volume":"57","author":"Y Shibamoto","year":"2016","unstructured":"Shibamoto Y, Miyakawa A, Otsuka S, Iwata H. Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules? J Radiat Res. 2016;57(Suppl\u00a01):i76\u201382.","journal-title":"J Radiat Res"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3171\/2014.10.JNS141610","volume":"123","author":"PK Sneed","year":"2015","unstructured":"Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015;123:373\u201386.","journal-title":"J Neurosurg"},{"key":"11_CR10","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.3109\/0284186X.2010.486796","volume":"49","author":"R Ruggieri","year":"2010","unstructured":"Ruggieri R, Naccarato S, Nahum AE. Severe hypofractionation: non-homogeneous tumour dose delivery can counteract tumour hypoxia. Acta Oncol. 2010;49:1304\u201314.","journal-title":"Acta Oncol"},{"key":"11_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.7785\/tcrt.2012.500232","volume":"11","author":"A Sahgal","year":"2012","unstructured":"Sahgal A, Ma L, Fowler J, Weinberg V, Gibbs I, Gerszten PC, Ryu S, Soltys S, Chang E, Wong CS, Larson DA. Impact of dose hot spots on spinal cord tolerance following stereotactic body radiotherapy: a generalized biological effective dose analysis. Technol Cancer Res Treat. 2012;11:35\u201340.","journal-title":"Technol Cancer Res Treat"},{"key":"11_CR12","doi-asserted-by":"publisher","first-page":"7843","DOI":"10.1088\/0031-9155\/57\/23\/7843","volume":"57","author":"L Ma","year":"2012","unstructured":"Ma L, Kirby N, Korol R, Larson DA, Sahgal A. Assessing small-volume spinal cord dose for repeat spinal stereotactic body radiotherapy treatments. Phys Med Biol. 2012;57:7843\u201351.","journal-title":"Phys Med Biol"},{"key":"11_CR13","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.1088\/0031-9155\/56\/22\/015","volume":"56","author":"L Ma","year":"2011","unstructured":"Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011;56:7247\u201356.","journal-title":"Phys Med Biol"},{"issue":"Suppl","key":"11_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3171\/JNS\/2008\/109\/12\/S4","volume":"109","author":"L Ma","year":"2008","unstructured":"Ma L, Verhey L, Chuang C, Descovich M, Smith V, Huang K, McDermott M, Sneed P. Effect of composite sector collimation on average dose fall-off for Gamma Knife Perfexion. J Neurosurg. 2008;109(Suppl):15\u201320.","journal-title":"J Neurosurg"},{"key":"11_CR15","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.ijrobp.2009.07.1721","volume":"76","author":"L Ma","year":"2010","unstructured":"Ma L, Sahgal A, Descovich M, Cho YB, Chuang C, Huang K, Laperriere NJ, Shrieve DC, Larson DA. Equivalence in dose fall-off for isocentric and nonisocentric intracranial treatment modalities and its impact on dose fractionation schemes. Int J Radiat Oncol Biol Phys. 2010;76:943\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.ijrobp.2010.10.007","volume":"79","author":"DJ Carlson","year":"2011","unstructured":"Carlson DJ, Keall PJ, Loo BW Jr, Chen ZJ, Brown JM. Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia. Int J Radiat Oncol Biol Phys. 2011;79:1188\u201395.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.semradonc.2008.04.004","volume":"18","author":"DJ Brenner","year":"2008","unstructured":"Brenner DJ. The linear\u2013quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol. 2008;18:234\u20139.","journal-title":"Semin Radiat Oncol"},{"key":"11_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.radonc.2013.09.005","volume":"109","author":"M Guckenberger","year":"2013","unstructured":"Guckenberger M, Klement RJ, Allg\u00e4uer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, Sterzing F, Wittig A, Andratschke N, Flentje M. Applicability of the linear\u2013quadratic formalism for modeling local tumor control probability in high dose per fraction stereotactic body radiotherapy for early stage non-small cell lung cancer. Radiother Oncol. 2013;109:13\u201320.","journal-title":"Radiother Oncol"}],"container-title":["Acta Neurochirurgica Supplement","Gamma Knife Neurosurgery in the Management of Intracranial Disorders II"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-69217-9_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T11:10:15Z","timestamp":1625051415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-69217-9_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030692162","9783030692179"],"references-count":18,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-69217-9_11","relation":{},"ISSN":["0065-1419","2197-8395"],"issn-type":[{"value":"0065-1419","type":"print"},{"value":"2197-8395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"1 July 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Drs. Ma and Sahgal have previously received educational honoraria and travel support from Elekta\u00a0AB. Dr.\u00a0Sahgal has received research grants from Elekta\u00a0AB and has served on the medical advisory board of Varian Medical Systems.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}