{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T06:36:42Z","timestamp":1743057402103,"version":"3.40.3"},"publisher-location":"Cham","reference-count":86,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030733582"},{"type":"electronic","value":"9783030733599"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-73359-9_4","type":"book-chapter","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T11:06:30Z","timestamp":1627902390000},"page":"55-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms"],"prefix":"10.1007","author":[{"given":"Huidi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"issue":"2","key":"4_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ygyno.2013.12.039","volume":"133","author":"Y Collins","year":"2014","unstructured":"Collins, Y., Holcomb, K., Chapman-Davis, E., Khabele, D., & Farley, J. H. (2014). Gynecologic cancer disparities: A report from the Health Disparities Taskforce of the Society of Gynecologic Oncology. Gynecologic Oncology, 133(2), 353\u2013361.","journal-title":"Gynecologic Oncology"},{"issue":"1","key":"4_CR2","first-page":"7","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel, R. L., Miller, K. D., & Jemal, A. (2016). Cancer statistics, 2016. CA: A Cancer Journal for Clinicians, 66(1), 7\u201330.","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"2","key":"4_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s13193-016-0501-9","volume":"7","author":"A Bhatt","year":"2016","unstructured":"Bhatt, A., & Glehen, O. (2016). The role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer: A review. Indian Journal of Surgical Oncology, 7(2), 188\u2013197.","journal-title":"Indian Journal of Surgical Oncology"},{"issue":"1","key":"4_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1177\/1078155207077948","volume":"13","author":"JM Saucier","year":"2007","unstructured":"Saucier, J. M., Yu, J., Gaikwad, A., Coleman, R. L., Wolf, J. K., & Smith, J. A. (2007). Determination of the optimal combination chemotherapy regimen for treatment of platinum-resistant ovarian cancer in nude mouse model. Journal of Oncology Pharmacy Practice, 13(1), 39\u201345.","journal-title":"Journal of Oncology Pharmacy Practice"},{"issue":"2","key":"4_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4103\/0976-9668.92322","volume":"2","author":"AF Al-Anazi","year":"2011","unstructured":"Al-Anazi, A. F., Qureshi, V. F., Javaid, K., & Qureshi, S. (2011). Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: An overview. Journal of Natural Science Biology and Medicine, 2(2), 154\u2013163.","journal-title":"Journal of Natural Science Biology and Medicine"},{"issue":"3c","key":"4_CR6","first-page":"2357","volume":"25","author":"J Wietrzyk","year":"2005","unstructured":"Wietrzyk, J., Grynkiewicz, G., & Opolski, A. (2005). Phytoestrogens in cancer prevention and therapy\u2014Mechanisms of their biological activity. Anticancer Research, 25(3c), 2357\u20132366.","journal-title":"Anticancer Research"},{"issue":"1\u20132","key":"4_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S1570-0232(02)00281-7","volume":"777","author":"LQ Wang","year":"2002","unstructured":"Wang, L. Q. (2002). Mammalian phytoestrogens: Enterodiol and enterolactone. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 777(1\u20132), 289\u2013309.","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"4_CR8","unstructured":"Martinchik, A. N., & Zubtsov, V. V. (2012). [Phytoestrogenis properties of flaxseed lignans]. Voprosy Pitaniia, 81(6):61\u201366."},{"issue":"5","key":"4_CR9","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1002\/ijc.21464","volume":"118","author":"KA Power","year":"2006","unstructured":"Power, K. A., Saarinen, N. M., Chen, J. M., & Thompson, L. U. (2006). Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. International Journal of Cancer, 118(5), 1316\u20131320.","journal-title":"International Journal of Cancer"},{"issue":"6","key":"4_CR10","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1007\/s00253-013-5111-7","volume":"98","author":"YL Tao","year":"2014","unstructured":"Tao, Y. L., Yang, D. H., Zhang, Y. T., Zhang, Y., Wang, Z. Q., Wang, Y. S., Cai, S. Q., & Liu, S. L. (2014). Cloning, expression, and characterization of the beta-glucosidase hydrolyzing secoisolariciresinol diglucoside to secoisolariciresinol from Bacteroides uniformis ZL1. Applied Microbiology and Biotechnology, 98(6), 2519\u20132531.","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"1","key":"4_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.procbio.2013.10.003","volume":"49","author":"H-Y Zhu","year":"2014","unstructured":"Zhu, H.-Y., Li, M.-X., Yang, D.-H., Tao, Y.-L., Zhang, Y., & Liu, S.-L. (2014). Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies. Process Biochemistry, 49(1), 19\u201324.","journal-title":"Process Biochemistry"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1471-2180-10-115","volume":"10","author":"CZ Wang","year":"2010","unstructured":"Wang, C. Z., Ma, X. Q., Yang, D. H., Guo, Z. R., Liu, G. R., Zhao, G. X., Tang, J., Zhang, Y. N., Ma, M., Cai, S. Q., et al. (2010). Production of enterodiol from defatted flaxseeds through biotransformation by human intestinal bacteria. BMC Microbiology, 10, 115.","journal-title":"BMC Microbiology"},{"issue":"3\u20138","key":"4_CR13","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0960-0760(92)90393-W","volume":"41","author":"Y Mousavi","year":"1992","unstructured":"Mousavi, Y., & Adlercreutz, H. (1992). Enterolactone and estradiol inhibit each other\u2019s proliferative effect on MCF-7 breast cancer cells in culture. The Journal of Steroid Biochemistry and Molecular Biology, 41(3\u20138), 615\u2013619.","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"1","key":"4_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bone.2005.12.015","volume":"39","author":"KA Power","year":"2006","unstructured":"Power, K. A., Ward, W. E., Chen, J. M., Saarinen, N. M., & Thompson, L. U. (2006). Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone, 39(1), 117\u2013124.","journal-title":"Bone"},{"issue":"5\u20136","key":"4_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000019912","volume":"35","author":"L Denis","year":"1999","unstructured":"Denis, L., Morton, M. S., & Griffiths, K. (1999). Diet and its preventive role in prostatic disease. European Urology, 35(5\u20136), 377\u2013387.","journal-title":"European Urology"},{"issue":"1","key":"4_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/jn\/136.1.112","volume":"136","author":"J Hallund","year":"2006","unstructured":"Hallund, J., Ravn-Haren, G., Bugel, S., Tholstrup, T., & Tetens, I. (2006). A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women. The Journal of Nutrition, 136(1), 112\u2013116.","journal-title":"The Journal of Nutrition"},{"issue":"16","key":"4_CR17","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1158\/1078-0432.CCR-09-0661","volume":"15","author":"Y Zhou","year":"2009","unstructured":"Zhou, Y., Liu, Y. E., Cao, J., Zeng, G., Shen, C., Li, Y., Zhou, M., Chen, Y., Pu, W., Potters, L., et al. (2009). Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clinical Cancer Research, 15(16), 5161\u20135169.","journal-title":"Clinical Cancer Research"},{"issue":"4","key":"4_CR18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/BF01623898","volume":"9","author":"K Prasad","year":"2000","unstructured":"Prasad, K. (2000). Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. International Journal of Angiology, 9(4), 220\u2013225.","journal-title":"International Journal of Angiology"},{"issue":"5B","key":"4_CR19","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/0022-4731(86)90310-9","volume":"25","author":"H Adlercreutz","year":"1986","unstructured":"Adlercreutz, H., Fotsis, T., Bannwart, C., Wahala, K., Makela, T., Brunow, G., & Hase, T. (1986). Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. Journal of Steroid Biochemistry, 25(5B), 791\u2013797.","journal-title":"Journal of Steroid Biochemistry"},{"issue":"11","key":"4_CR20","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1080\/10408398.2013.789823","volume":"56","author":"JM Landete","year":"2016","unstructured":"Landete, J. M., Arques, J., Medina, M., Gaya, P., de Las Rivas, B., & Munoz, R. (2016). Bioactivation of phytoestrogens: Intestinal bacteria and health. Critical Reviews in Food Science and Nutrition, 56(11), 1826\u20131843.","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"1","key":"4_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10549-009-0681-x","volume":"122","author":"SE McCann","year":"2010","unstructured":"McCann, S. E., Thompson, L. U., Nie, J., Dorn, J., Trevisan, M., Shields, P. G., Ambrosone, C. B., Edge, S. B., Li, H. F., Kasprzak, C., et al. (2010). Dietary lignan intakes in relation to survival among women with breast cancer: The Western New York Exposures and Breast Cancer (WEB) Study. Breast Cancer Research and Treatment, 122(1), 229\u2013235.","journal-title":"Breast Cancer Research and Treatment"},{"issue":"2","key":"4_CR22","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s10549-011-1881-8","volume":"132","author":"P Guglielmini","year":"2012","unstructured":"Guglielmini, P., Rubagotti, A., & Boccardo, F. (2012). Serum enterolactone levels and mortality outcome in women with early breast cancer: A retrospective cohort study. Breast Cancer Research and Treatment, 132(2), 661\u2013668.","journal-title":"Breast Cancer Research and Treatment"},{"issue":"8","key":"4_CR23","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/bjc.2011.374","volume":"105","author":"K Buck","year":"2011","unstructured":"Buck, K., Zaineddin, A. K., Vrieling, A., Heinz, J., Linseisen, J., Flesch-Janys, D., & Chang-Claude, J. (2011). Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer. British Journal of Cancer, 105(8), 1151\u20131157.","journal-title":"British Journal of Cancer"},{"issue":"1","key":"4_CR24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1207\/S15327914nc391_8","volume":"39","author":"AM Hutchins","year":"2001","unstructured":"Hutchins, A. M., Martini, M. C., Olson, B. A., Thomas, W., & Slavin, J. L. (2001). Flaxseed consumption influences endogenous hormone concentrations in postmenopausal women. Nutrition and Cancer, 39(1), 58\u201365.","journal-title":"Nutrition and Cancer"},{"issue":"1","key":"4_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.4103\/0019-509X.98948","volume":"49","author":"AV Mali","year":"2012","unstructured":"Mali, A. V., Wagh, U. V., Hegde, M. V., Chandorkar, S. S., Surve, S. V., & Patole, M. V. (2012). In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. Indian Journal of Cancer, 49(1), 181\u2013187.","journal-title":"Indian Journal of Cancer"},{"issue":"4","key":"4_CR26","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0016-5085(84)80129-8","volume":"86","author":"H Adlercreutz","year":"1984","unstructured":"Adlercreutz, H. (1984). Does fiber-rich food containing animal lignan precursors protect against both colon and breast cancer? An extension of the \u201cfiber hypothesis\u201d. Gastroenterology, 86(4), 761\u2013764.","journal-title":"Gastroenterology"},{"issue":"2","key":"4_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/01635589209514182","volume":"17","author":"M Serraino","year":"1992","unstructured":"Serraino, M., & Thompson, L. U. (1992). The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutrition and Cancer, 17(2), 153\u2013159.","journal-title":"Nutrition and Cancer"},{"issue":"3","key":"4_CR28","first-page":"184","volume":"4","author":"A Bommareddy","year":"2010","unstructured":"Bommareddy, A., Zhang, X. Y., Kaushik, R. S., & Dwivedi, C. (2010). Effects of components present in flaxseed on human colon adenocarcinoma Caco-2 cells: Possible mechanisms of flaxseed on colon cancer development in animals. Drug Discov Ther, 4(3), 184\u2013189.","journal-title":"Drug Discov Ther"},{"issue":"1","key":"4_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1158\/0008-5472.CAN-10-2289","volume":"71","author":"G Lindahl","year":"2011","unstructured":"Lindahl, G., Saarinen, N., Abrahamsson, A., & Dabrosin, C. (2011). Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer. Cancer Research, 71(1), 51\u201360.","journal-title":"Cancer Research"},{"issue":"3","key":"4_CR30","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/ijc.25052","volume":"127","author":"NM Saarinen","year":"2010","unstructured":"Saarinen, N. M., Abrahamsson, A., & Dabrosin, C. (2010). Estrogen-induced angiogenic factors derived from stromal and cancer cells are differently regulated by enterolactone and genistein in human breast cancer in vivo. International Journal of Cancer, 127(3), 737\u2013745.","journal-title":"International Journal of Cancer"},{"issue":"3B","key":"4_CR31","first-page":"2269","volume":"25","author":"N Danbara","year":"2005","unstructured":"Danbara, N., Yuri, T., Tsujita-Kyutoku, M., Tsukamoto, R., Uehara, N., & Tsubura, A. (2005). Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. Anticancer Research, 25(3B), 2269\u20132276.","journal-title":"Anticancer Research"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jsbmb.2016.02.028","volume":"159","author":"A Dikshit","year":"2016","unstructured":"Dikshit, A., Gao, C., Small, C., Hales, K., & Hales, D. B. (2016). Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries. The Journal of Steroid Biochemistry and Molecular Biology, 159, 73\u201385.","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"9","key":"4_CR33","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1017\/S000711451500029X","volume":"113","author":"A Dikshit","year":"2015","unstructured":"Dikshit, A., Gomes Filho, M. A., Eilati, E., McGee, S., Small, C., Gao, C., Klug, T., & Hales, D. B. (2015). Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British Journal of Nutrition, 113(9), 1384\u20131395.","journal-title":"The British Journal of Nutrition"},{"issue":"1","key":"4_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13048-017-0346-z","volume":"10","author":"H Liu","year":"2017","unstructured":"Liu, H., Liu, J., Wang, S., Zeng, Z., Li, T., Liu, Y., Mastriani, E., Li, Q. H., Bao, H. X., Zhou, Y. J., et al. (2017). Enterolactone has stronger effects than enterodiol on ovarian cancer. J Ovarian Res, 10(1), 49.","journal-title":"J Ovarian Res"},{"issue":"5","key":"4_CR35","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s00394-013-0615-6","volume":"53","author":"M Spilmont","year":"2014","unstructured":"Spilmont, M., Leotoing, L., Davicco, M. J., Lebecque, P., Mercier, S., Miot-Noirault, E., Pilet, P., Rios, L., Wittrant, Y., & Coxam, V. (2014). Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis. European Journal of Nutrition, 53(5), 1155\u20131164.","journal-title":"European Journal of Nutrition"},{"issue":"6","key":"4_CR36","doi-asserted-by":"publisher","first-page":"8644","DOI":"10.3390\/molecules19068644","volume":"19","author":"S Costantini","year":"2014","unstructured":"Costantini, S., Rusolo, F., De Vito, V., Moccia, S., Picariello, G., Capone, F., Guerriero, E., Castello, G., & Volpe, M. G. (2014). Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines. Molecules, 19(6), 8644\u20138660.","journal-title":"Molecules"},{"issue":"51","key":"4_CR37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1080\/10408391003748100","volume":"51","author":"A Faria","year":"2011","unstructured":"Faria, A., & Calhau, C. (2011). The bioactivity of pomegranate: Impact on health and disease. Critical Reviews in Food Science & Nutrition, 51(51), 626\u2013634.","journal-title":"Critical Reviews in Food Science & Nutrition"},{"issue":"16","key":"4_CR38","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1200\/JCO.2008.20.6235","volume":"27","author":"AR Amin","year":"2009","unstructured":"Amin, A. R., Kucuk, O., Khuri, F. R., & Shin, D. M. (2009). Perspectives for cancer prevention with natural compounds. Journal of Clinical Oncology, 27(16), 2712\u20132725.","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"4_CR39","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.semcancer.2007.05.004","volume":"17","author":"DN Syed","year":"2007","unstructured":"Syed, D. N., Afaq, F., & Mukhtar, H. (2007). Pomegranate derived products for cancer chemoprevention. Seminars in Cancer Biology, 17(5), 377\u2013385.","journal-title":"Seminars in Cancer Biology"},{"issue":"2","key":"4_CR40","first-page":"128","volume":"13","author":"JS Jurenka","year":"2008","unstructured":"Jurenka, J. S. (2008). Therapeutic applications of pomegranate (Punica granatum L.): A review. Alternative Medicine Review: A Journal of Clinical Therapeutic, 13(2), 128\u2013144.","journal-title":"Alternative Medicine Review: A Journal of Clinical Therapeutic"},{"issue":"6","key":"4_CR41","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jnutbio.2005.01.006","volume":"16","author":"NP Seeram","year":"2005","unstructured":"Seeram, N. P., Adams, L. S., Henning, S. M., Niu, Y., Zhang, Y., Nair, M. G., & Heber, D. (2005). In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Journal of Nutritional Biochemistry, 16(6), 360\u2013367.","journal-title":"Journal of Nutritional Biochemistry"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/938475","volume":"2015","author":"E Turrini","year":"2015","unstructured":"Turrini, E., Ferruzzi, L., & Fimognari, C. (2015). Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxidative Medicine & Cellular Longevity, 2015, 1\u201319.","journal-title":"Oxidative Medicine & Cellular Longevity"},{"issue":"1","key":"4_CR43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2174\/138955709787001712","volume":"9","author":"M L\u00f3pezl\u00e1zaro","year":"2009","unstructured":"L\u00f3pezl\u00e1zaro, M. (2009). Distribution and biological activities of the flavonoid luteolin. Mini Reviews in Medicinal Chemistry, 9(1), 31\u201359.","journal-title":"Mini Reviews in Medicinal Chemistry"},{"issue":"19","key":"4_CR44","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.1016\/j.bmcl.2014.07.093","volume":"24","author":"K Amrutha","year":"2014","unstructured":"Amrutha, K., Nanjan, P., Shaji, S. K., Sunilkumar, D., Subhalakshmi, K., Rajakrishna, L., & Banerji, A. (2014). Discovery of lesser known flavones as inhibitors of NF-\u03baB signaling in MDA-MB-231 breast cancer cells\u2014A SAR study. Bioorganic & Medicinal Chemistry Letters, 24(19), 4735\u20134742.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"11","key":"4_CR45","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1177\/0960327114522502","volume":"33","author":"AK Pandurangan","year":"2014","unstructured":"Pandurangan, A. K., Dharmalingam, P., Sadagopan, S. K., & Ganapasam, S. (2014). Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis. Human & Experimental Toxicology, 33(11), 1176\u20131185.","journal-title":"Human & Experimental Toxicology"},{"issue":"10","key":"4_CR46","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1093\/jn\/136.10.2481","volume":"136","author":"NP Seeram","year":"2006","unstructured":"Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M., Li, Z., & Heber, D. (2006). Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. Journal of Nutrition, 136(10), 2481\u20132485.","journal-title":"Journal of Nutrition"},{"issue":"10","key":"4_CR47","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.1021\/jf000404a","volume":"48","author":"MI Gil","year":"2000","unstructured":"Gil, M. I., Tom\u00e1sbarber\u00e1n, F. A., Hesspierce, B., Holcroft, D. M., & Kader, A. A. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural & Food Chemistry, 48(10), 4581\u20134589.","journal-title":"Journal of Agricultural & Food Chemistry"},{"issue":"4","key":"4_CR48","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/01.cej.0000136571.70998.5a","volume":"13","author":"R Mehta","year":"2004","unstructured":"Mehta, R., & Lansky, E. P. (2004). Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. European Journal of Cancer Prevention, 13(4), 345\u2013348.","journal-title":"European Journal of Cancer Prevention"},{"issue":"12","key":"4_CR49","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1111\/j.1349-7006.1994.tb02932.x","volume":"85","author":"H Tsuda","year":"1994","unstructured":"Tsuda, H., Uehara, N., Iwahori, Y., Asamoto, M., Iigo, M., Nagao, M., Matsumoto, K., Ito, M., & Hirono, I. (1994). Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat. Japanese Journal of Cancer Research, 85(12), 1214\u20131219.","journal-title":"Japanese Journal of Cancer Research"},{"issue":"11","key":"4_CR50","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1016\/j.fct.2008.08.023","volume":"46","author":"JC Tharappel","year":"2008","unstructured":"Tharappel, J. C., Lehmler, H. J., Srinivasan, C., Robertson, L. W., Spear, B. T., & Glauert, H. P. (2008). Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3\u2032,4,4\u2032-tetrachlorobiphenyl (PCB-77). Food and Chemical Toxicology, 46(11), 3467\u20133474.","journal-title":"Food and Chemical Toxicology"},{"issue":"6","key":"4_CR51","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/mc.21995","volume":"53","author":"AB Shirode","year":"2014","unstructured":"Shirode, A. B., Kovvuru, P., Chittur, S. V., Henning, S. M., Heber, D., & Reliene, R. (2014). Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks. Molecular Carcinogenesis, 53(6), 458\u2013470.","journal-title":"Molecular Carcinogenesis"},{"issue":"9","key":"4_CR52","doi-asserted-by":"publisher","first-page":"14949","DOI":"10.3390\/ijms150914949","volume":"15","author":"L Wang","year":"2014","unstructured":"Wang, L., & Martins-Green, M. (2014). Pomegranate and its components as alternative treatment for prostate cancer. International Journal of Molecular Sciences, 15(9), 14949\u201314966.","journal-title":"International Journal of Molecular Sciences"},{"issue":"16","key":"4_CR53","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.3748\/wjg.v20.i16.4618","volume":"20","author":"SK Jaganathan","year":"2014","unstructured":"Jaganathan, S. K., Vellayappan, M. V., Narasimhan, G., & Supriyanto, E. (2014). Role of pomegranate and citrus fruit juices in colon cancer prevention. World Journal of Gastroenterology, 20(16), 4618\u20134625.","journal-title":"World Journal of Gastroenterology"},{"issue":"12","key":"4_CR54","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1080\/15384047.2017.1394542","volume":"18","author":"H Liu","year":"2017","unstructured":"Liu, H., Zeng, Z., Wang, S., Li, T., Mastriani, E., Li, Q. H., Bao, H. X., Zhou, Y. J., Wang, X., Liu, Y., et al. (2017). Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9. Cancer Biology & Therapy, 18(12), 990\u2013999.","journal-title":"Cancer Biology & Therapy"},{"issue":"2","key":"4_CR55","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0304-3835(00)00678-9","volume":"163","author":"N Yoshimi","year":"2001","unstructured":"Yoshimi, N., Matsunaga, K., Katayama, M., Yamada, Y., Kuno, T., Qiao, Z., Hara, A., Yamahara, J., & Mori, H. (2001). The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Letters, 163(2), 163\u2013170.","journal-title":"Cancer Letters"},{"issue":"14","key":"4_CR56","doi-asserted-by":"publisher","first-page":"5599","DOI":"10.1021\/jf800738r","volume":"56","author":"JC Barreto","year":"2008","unstructured":"Barreto, J. C., Trevisan, M. T. S., Hull, W. E., Gerhard, E., Brito, E. S., De Beate, P., Gerd, W., Bertold, S., & Owen, R. W. (2008). Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agricultural & Food Chemistry, 56(14), 5599.","journal-title":"Journal of Agricultural & Food Chemistry"},{"issue":"9","key":"4_CR57","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1080\/10826076.2014.999199","volume":"38","author":"JJ Chavan","year":"2015","unstructured":"Chavan, J. J., Ghadage, D. M., Kshirsagar, P. R., & Kudale, S. S. (2015). Optimization of extraction techniques and RP-HPLC analysis of antidiabetic and anticancer drug mangiferin from roots of \u2018Saptarangi\u2019 (Salacia chinensisL.). Journal of Liquid Chromatography & Related Technologies, 38(9), 963\u2013969.","journal-title":"Journal of Liquid Chromatography & Related Technologies"},{"issue":"9","key":"4_CR58","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1039\/C7FO00190H","volume":"8","author":"BM Burton-Freeman","year":"2017","unstructured":"Burton-Freeman, B. M., Sandhu, A. K., & Edirisinghe, I. (2017). Mangos and their bioactive components: Adding variety to the fruit plate for health. Food & Function, 8(9), 3010.","journal-title":"Food & Function"},{"issue":"21","key":"4_CR59","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.2174\/092986705774370691","volume":"12","author":"MM Pinto","year":"2005","unstructured":"Pinto, M. M., Sousa, M. E., & Nascimento, M. S. (2005). Xanthone derivatives: New insights in biological activities. Current Medicinal Chemistry, 12(21), 2517\u20132538.","journal-title":"Current Medicinal Chemistry"},{"issue":"1","key":"4_CR60","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.taap.2013.05.011","volume":"272","author":"H Li","year":"2013","unstructured":"Li, H., Huang, J., Yang, B., Xiang, T., Yin, X., Peng, W., Cheng, W., Wan, J., Luo, F., & Li, H. (2013). Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and \u03b2-catenin signaling pathway. Toxicology & Applied Pharmacology, 272(1), 180\u2013190.","journal-title":"Toxicology & Applied Pharmacology"},{"issue":"4","key":"4_CR61","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.4103\/0973-1482.137966","volume":"10","author":"P Rajendran","year":"2014","unstructured":"Rajendran, P., Rengarajan, T., Nishigaki, I., Ekambaram, G., & Sakthisekaran, D. (2014). Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice. Journal of Cancer Research & Therapeutics, 10(4), 1033\u20131039.","journal-title":"Journal of Cancer Research & Therapeutics"},{"issue":"2","key":"4_CR62","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/aps.2013.165","volume":"35","author":"BP Zhang","year":"2014","unstructured":"Zhang, B. P., Zhao, J., Li, S. S., Yang, L. J., Zeng, L. L., Chen, Y., & Fang, J. (2014). Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacologica Sinica, 35(2), 257\u2013266.","journal-title":"Acta Pharmacologica Sinica"},{"issue":"2","key":"4_CR63","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.4238\/2015.May.12.2","volume":"14","author":"ZG Peng","year":"2015","unstructured":"Peng, Z. G., Yao, Y. B., Yang, J., Tang, Y. L., & Huang, X. (2015). Mangiferin induces cell cycle arrest at G2\/M phase through ATR-Chk1 pathway in HL-60 leukemia cells. Genetics & Molecular Research, 14(2), 4989\u20135002.","journal-title":"Genetics & Molecular Research"},{"issue":"17","key":"4_CR64","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.7314\/APJCP.2014.15.17.7065","volume":"15","author":"L-L Pan","year":"2014","unstructured":"Pan, L.-L., Wang, A.-Y., Huang, Y.-Q., Luo, Y., & Ling, M. (2014). Mangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell line. Asian Pacific Journal of Cancer Prevention, 15(17), 7065\u20137068.","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"2","key":"4_CR65","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cbi.2011.06.002","volume":"193","author":"S Das","year":"2011","unstructured":"Das, S., Rao, B. N., & Rao, B. S. S. (2011). Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential. Chemico-Biological Interactions, 193(2), 129\u2013140.","journal-title":"Chemico-Biological Interactions"},{"issue":"3","key":"4_CR66","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0378-8741(00)00181-1","volume":"72","author":"M Davydov","year":"2000","unstructured":"Davydov, M., & Krikorian, A. (2000). Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: A closer look. Journal of Ethnopharmacology, 72(3), 345\u2013393.","journal-title":"Journal of Ethnopharmacology"},{"issue":"2","key":"4_CR67","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1055\/s-2008-1034275","volume":"74","author":"N Ho-Shan","year":"2008","unstructured":"Ho-Shan, N., I-Min, L., Juei-Tang, C., Che-Ling, L., & Feng-Lin, H. (2008). Hypoglycemic effect of syringin from Eleutherococcus senticosus in Streptozotocin-induced diabetic rats. Planta Medica, 74(2), 109\u2013113.","journal-title":"Planta Medica"},{"issue":"3","key":"4_CR68","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1123\/ijsnem.19.3.298","volume":"19","author":"MS Bahrke","year":"2009","unstructured":"Bahrke, M. S., Morgan, W. P., & Stegner, A. (2009). Is ginseng an ergogenic aid? International Journal of Sport Nutrition & Exercise Metabolism, 19(3), 298\u2013322.","journal-title":"International Journal of Sport Nutrition & Exercise Metabolism"},{"issue":"4","key":"4_CR69","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1123\/ijsnem.10.4.444","volume":"10","author":"LF Eschbach","year":"2000","unstructured":"Eschbach, L. F., Webster, M. J., Boyd, J. C., Mcarthur, P. D., & Evetovich, T. K. (2000). The effect of Siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance. International Journal of Sport Nutrition & Exercise Metabolism, 10(4), 444\u2013451.","journal-title":"International Journal of Sport Nutrition & Exercise Metabolism"},{"issue":"9","key":"4_CR70","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.4236\/health.2013.59205","volume":"5","author":"A Arouca","year":"2013","unstructured":"Arouca, A., & Grassi-Kassisse, D. M. (2013). Eleutherococcus senticosus: Studies and effects. Health, 5(9), 1509\u20131515.","journal-title":"Health"},{"issue":"6","key":"4_CR71","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1248\/cpb.38.1763","volume":"38","author":"S Nishibe","year":"1990","unstructured":"Nishibe, S., Kinoshita, H., Takeda, H., & Okano, G. (1990). Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chemical & Pharmaceutical Bulletin, 38(6), 1763\u20131765.","journal-title":"Chemical & Pharmaceutical Bulletin"},{"issue":"2","key":"4_CR72","first-page":"83","volume":"66","author":"H Linzhang","year":"2011","unstructured":"Linzhang, H., Hongfang, Z., Baokang, H., Chengjian, Z., Wei, P., & Luping, Q. (2011). Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Die Pharmazie, 66(2), 83\u201397.","journal-title":"Die Pharmazie"},{"key":"4_CR73","unstructured":"Chen, L. I., Wang, X. Y., Xu-Wei, H. U., Fang, H. T., & Qiao, S. Y. (2008). [Determination of eleutheroside B in antifatigue fraction of Acanthopanax senticosus by HPLC]. Zhongguo Zhong yao za zhi, 33(23):2800\u20132802."},{"issue":"6","key":"4_CR74","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","volume":"15","author":"RP Verma","year":"2007","unstructured":"Verma, R. P., & Hansch, C. (2007). Matrix metalloproteinases (MMPs): Chemical\u2013biological functions and (Q)SARs. Bioorganic & Medicinal Chemistry, 15(6), 2223\u20132268.","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"11","key":"4_CR75","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S1074-5521(96)90178-7","volume":"3","author":"LM Coussens","year":"1996","unstructured":"Coussens, L. M., & Werb, Z. (1996). Matrix metalloproteinases and the development of cancer. Chemistry & Biology, 3(11), 895\u2013904.","journal-title":"Chemistry & Biology"},{"issue":"22","key":"4_CR76","doi-asserted-by":"publisher","first-page":"10902","DOI":"10.1158\/0008-5472.CAN-06-2217","volume":"66","author":"LWT Cheung","year":"2006","unstructured":"Cheung, L. W. T., Leung, P. C. K., & Wong, A. S. T. (2006). Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9. Cancer Research, 66(22), 10902\u201310910.","journal-title":"Cancer Research"},{"issue":"3","key":"4_CR77","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.3892\/or.2012.2214","volume":"29","author":"YM Lu","year":"2012","unstructured":"Lu, Y. M., Rong, M. L., Shang, C., Wang, N., Li, X., Zhao, Y. Y., & Zhang, S. L. (2012). Suppression of HER-2 via siRNA interference promotes apoptosis and decreases metastatic potential of SKOV-3 human ovarian carcinoma cells. Oncology Reports, 29(3), 1133\u20131139.","journal-title":"Oncology Reports"},{"issue":"8","key":"4_CR78","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1089\/dna.2013.2289","volume":"33","author":"Y Yu","year":"2014","unstructured":"Yu, Y., Li, H., Xue, B., Jiang, X., Huang, K., Ge, J., Zhang, H., & Chen, B. (2014). SDF-1\/CXCR7 axis enhances ovarian cancer cell invasion by MMP-9 expression through p38 MAPK pathway. DNA & Cell Biology, 33(8), 543\u2013549.","journal-title":"DNA & Cell Biology"},{"issue":"9","key":"4_CR79","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/bjc.2012.80","volume":"106","author":"AM Langers","year":"2012","unstructured":"Langers, A. M., Verspaget, H. W., Hawinkels, L. J., Kubben, F. J., van Duijn, W., van der Reijden, J. J., Hardwick, J. C., Hommes, D. W., & Sier, C. F. (2012). MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. British Journal of Cancer, 106(9), 1495\u20131498.","journal-title":"British Journal of Cancer"},{"key":"4_CR80","unstructured":"Mieszalo, K., Lawicki, S., & Szmitkowski, M. (2016). [The utility of metalloproteinases (MMPs) and their inhibitors (TIMPs) in diagnostics of gynecological malignancies]. Polski Merkuriusz Lekarski, 40(237):193\u2013197."},{"key":"4_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/938475","volume":"2014","author":"E Turrini","year":"2015","unstructured":"Turrini, E., Ferruzzi, L., & Fimognari, C. (2015). Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxidative Medicine & Cellular Longevity, 2014, 1\u201319.","journal-title":"Oxidative Medicine & Cellular Longevity"},{"issue":"9","key":"4_CR82","first-page":"2699","volume":"31","author":"V Nair","year":"2011","unstructured":"Nair, V., Dai, Z., Khan, M., & Ciolino, H. P. (2011). Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells. Anticancer Research, 31(9), 2699\u20132704.","journal-title":"Anticancer Research"},{"issue":"5","key":"4_CR83","first-page":"296","volume":"2011","author":"ST Huang","year":"2011","unstructured":"Huang, S. T., Wang, C. Y., Yang, R. C., Wu, H. T., Yang, S. H., Cheng, Y. C., & Pang, J. H. S. (2011). Ellagic acid, the active compound of Phyllanthus urinaria, exerts in vivo anti-angiogenic effect and inhibits MMP-2 activity. Evidence-Based Complementary and Alternative Medicine, 2011(5), 296\u2013297.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"2","key":"4_CR84","first-page":"386","volume":"2013","author":"C Yuan-Chiang","year":"2013","unstructured":"Yuan-Chiang, C., Li-Cheng, L., Ming-Hsiu, T., Yu-Jen, C., Yi-Ying, C., Shih-Ping, Y., & Chih-Ping, H. (2013). The inhibitory effect of ellagic acid on cell growth of ovarian carcinoma cells. Evidence-Based Complementary and Alternative Medicine, 2013(2), 386.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1\u20132","key":"4_CR85","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0021-9673(00)00414-3","volume":"896","author":"Y Amakura","year":"2000","unstructured":"Amakura, Y., Mai, O., Tsuji, S., & Tonogai, Y. (2000). High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. Journal of Chromatography A, 896(1\u20132), 87\u201393.","journal-title":"Journal of Chromatography A"},{"issue":"6","key":"4_CR86","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1021\/jf000892m","volume":"49","author":"KH Miean","year":"2001","unstructured":"Miean, K. H., & Mohamed, S. (2001). Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. Journal of Agricultural & Food Chemistry, 49(6), 3106\u20133112.","journal-title":"Journal of Agricultural & Food Chemistry"}],"container-title":["Advances in Experimental Medicine and Biology","Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-73359-9_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T12:04:12Z","timestamp":1627905852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-73359-9_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030733582","9783030733599"],"references-count":86,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-73359-9_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"3 August 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}