{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:29:32Z","timestamp":1780450172267,"version":"3.54.1"},"publisher-location":"Cham","reference-count":26,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030740450","type":"print"},{"value":"9783030740467","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-74046-7_18","type":"book-chapter","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T18:02:39Z","timestamp":1630087359000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders"],"prefix":"10.1007","author":[{"given":"Graziana","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijorn Omar","family":"Balzamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cacciamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Micera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"issue":"3","key":"18_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00125-010-1935-1","volume":"54","author":"TK Ali","year":"2011","unstructured":"Ali TK, Al-Gayyar MMH, Matragoon S et al (2011) Diabetes induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury. Diabetologia 54(3):657\u2013668","journal-title":"Diabetologia"},{"issue":"1","key":"18_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.5152\/balkanmedj.2013.003","volume":"30","author":"L Aloe","year":"2013","unstructured":"Aloe L, Chaldakov GN (2013) The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909\u20132012). Balkan Med J 30(1):4\u20137","journal-title":"Balkan Med J"},{"key":"18_CR3","doi-asserted-by":"publisher","first-page":"725928","DOI":"10.1155\/2014\/725928","volume":"2014","author":"BO Balzamino","year":"2014","unstructured":"Balzamino BO, Biamonte F, Esposito G et al (2014) Characterization of NGF, trkA (NGFR), and p75 (NTR) in retina of mice lacking Reelin glycoprotein. Int J Cell Biol 2014:725928. https:\/\/doi.org\/10.1155\/2014\/725928","journal-title":"Int J Cell Biol"},{"issue":"7","key":"18_CR4","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3109\/02713683.2015.1080282","volume":"41","author":"A Cacciamani","year":"2016","unstructured":"Cacciamani A, Parravano M, Scarinci F et al (2016) A simple spontaneous Vitreal reflux collecting procedure during intravitreal injection: set-up and validation studies. Curr Eye Res 41(7):971\u2013976. https:\/\/doi.org\/10.3109\/02713683.2015.1080282","journal-title":"Curr Eye Res"},{"issue":"1","key":"18_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00417-018-4169-4","volume":"257","author":"A Cacciamani","year":"2019","unstructured":"Cacciamani A, Esposito G, Scarinci F, Parravano M, Dinice L, Di Nicola M, Micera A (2019) Inflammatory mediators in the vitreal reflux of patients with diabetic macular edema. Graefes Arch Clin Exp Ophthalmol 257(1):187\u2013197. https:\/\/doi.org\/10.1007\/s00417-018-4169-4","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"18_CR6","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1007\/s00417-020-04685-w","volume":"258","author":"L Dinice","year":"2020","unstructured":"Dinice L, Cacciamani A, Esposito G et al (2020) Osteopontin in vitreous and idiopathic epiretinal membranes. Graefes Arch Clin Exp Ophthalmol 258(7):1503\u20131513. https:\/\/doi.org\/10.1007\/s00417-020-04685-w","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"6","key":"18_CR7","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/s41433-018-0021-7","volume":"32","author":"S Fogli","year":"2018","unstructured":"Fogli S, Del Re M, Rofi E, Posarelli C, Figus M, Danesi R (2018) Clinical pharmacology of intravitreal anti-VEGF drugs. Eye (Lond) 32(6):1010\u20131020. https:\/\/doi.org\/10.1038\/s41433-018-0021-7","journal-title":"Eye (Lond)"},{"issue":"3","key":"18_CR8","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","volume":"12","author":"R Gaudana","year":"2010","unstructured":"Gaudana R, Ananthula HK, Parenky A, Mitra AK (2010) Ocular drug delivery. AAPS J 12(3):348\u2013360. https:\/\/doi.org\/10.1208\/s12248-010-9183-3","journal-title":"AAPS J"},{"issue":"7","key":"18_CR9","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00018-017-2691-x","volume":"75","author":"M Giannaccini","year":"2018","unstructured":"Giannaccini M, Usai A, Chiellini F, Guadagni V, Andreazzoli M, Ori M, Pasqualetti M, Dente L, Raffa V (2018) Neurotrophin-conjugated nanoparticles prevent retina damage induced by oxidative stress. Cell Mol Life Sci 75(7):1255\u20131267. https:\/\/doi.org\/10.1007\/s00018-017-2691-x","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"18_CR10","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1167\/iovs.05-0301","volume":"46","author":"A Lambiase","year":"2005","unstructured":"Lambiase A, Tirassa P, Micera A, Aloe L, Bonini S (2005) Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats. Invest Ophthalmol Vis Sci 46(10):3800\u20133806. https:\/\/doi.org\/10.1167\/iovs.05-0301","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"27","key":"18_CR11","doi-asserted-by":"publisher","first-page":"18424","DOI":"10.1074\/jbc.M109.007104","volume":"284","author":"R Masoudi","year":"2009","unstructured":"Masoudi R, Ioannou MS, Coughlin MD et al (2009) Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. J Biol Chem 284(27):18424\u201318433. https:\/\/doi.org\/10.1074\/jbc.M109.007104","journal-title":"J Biol Chem"},{"issue":"6","key":"18_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.cytogfr.2004.09.003","volume":"15","author":"A Micera","year":"2004","unstructured":"Micera A, Lambiase A, Aloe L, Bonini S, Levi-Schaffer F, Bonini S (2004) Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases. Cytokine Growth Factor Rev 15(6):411\u2013417. https:\/\/doi.org\/10.1016\/j.cytogfr.2004.09.003","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3\u20134","key":"18_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.cytogfr.2007.04.004","volume":"18","author":"A Micera","year":"2007","unstructured":"Micera A, Lambiase A, Stampachiacchiere B et al (2007) Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate. Cytokine Growth Factor Rev 18(3\u20134):245\u2013256. https:\/\/doi.org\/10.1016\/j.cytogfr.2007.04.004","journal-title":"Cytokine Growth Factor Rev"},{"issue":"5","key":"18_CR14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4172\/2155-9570.1000483","volume":"6","author":"R Mohamed","year":"2015","unstructured":"Mohamed R, El-Remessy AB (2015) Imbalance of the nerve growth factor and its precursor: implication in diabetic retinopathy. J Clin Exp Ophthalmol 6(5):483. https:\/\/doi.org\/10.4172\/2155-9570.1000483","journal-title":"J Clin Exp Ophthalmol"},{"issue":"2","key":"18_CR15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.mcn.2010.12.002","volume":"46","author":"K Nakamura","year":"2011","unstructured":"Nakamura K, Tan F, Li Z, Thiele CJ (2011) NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1\u03b1. Mol Cell Neurosci 46(2):498\u2013506. https:\/\/doi.org\/10.1016\/j.mcn.2010.12.002","journal-title":"Mol Cell Neurosci"},{"issue":"6","key":"18_CR16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.cvsm.2015.06.005","volume":"45","author":"S Pizzirani","year":"2015","unstructured":"Pizzirani S, Gong H (2015) Functional anatomy of the outflow facilities. Vet Clin North Am Small Anim Pract 45(6):1101\u20131126. https:\/\/doi.org\/10.1016\/j.cvsm.2015.06.005","journal-title":"Vet Clin North Am Small Anim Pract"},{"issue":"4","key":"18_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124810","volume":"10","author":"ML Rocco","year":"2015","unstructured":"Rocco ML, Balzamino BO, Petrocchi Passeri P, Micera A, Aloe L (2015) Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa. PLoS One 10(4):e0124810. https:\/\/doi.org\/10.1371\/journal.pone.0124810","journal-title":"PLoS One"},{"issue":"3","key":"18_CR17","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00417-016-3567-8","volume":"255","author":"ML Rocco","year":"2017","unstructured":"Rocco ML, Balzamino BO, Esposito G et al (2017) NGF\/anti-VEGF combined exposure protects RCS retinal cells and photoreceptors that underwent a local worsening of inflammation. Graefes Arch Clin Exp Ophthalmol 255(3):567\u2013574. https:\/\/doi.org\/10.1007\/s00417-016-3567-8","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"18_CR18","doi-asserted-by":"publisher","first-page":"18297","DOI":"10.1002\/jcp.28462","volume":"234","author":"M Segatto","year":"2019","unstructured":"Segatto M, Fico E, Gharbiya M et al (2019) VEGF inhibition alters neurotrophin signalling pathways and induces caspase-3 activation and autophagy in rabbit retina. J Cell Physiol 234(10):18297\u201318307. https:\/\/doi.org\/10.1002\/jcp.28462","journal-title":"J Cell Physiol"},{"key":"18_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-2202-10-52","volume":"10","author":"S Sivilia","year":"2009","unstructured":"Sivilia S, Giuliani A, Fern\u00e1ndez M, Turba ME, Forni M, Massella A, De Sordi N, Giardino L, Calz\u00e0 L (2009 May 27) Intravitreal NGF administration counteracts retina degeneration after permanent carotid artery occlusion in rat. BMC Neurosci 10:52. https:\/\/doi.org\/10.1186\/1471-2202-10-52","journal-title":"BMC Neurosci"},{"key":"18_CR20","doi-asserted-by":"publisher","first-page":"3801570","DOI":"10.1155\/2016\/3801570","volume":"2016","author":"VJ Vieira-Potter","year":"2016","unstructured":"Vieira-Potter VJ, Karamichos D, Lee DJ (2016) Ocular complications of diabetes and therapeutic approaches. Biomed Res Int 2016:3801570. https:\/\/doi.org\/10.1155\/2016\/3801570","journal-title":"Biomed Res Int"},{"issue":"6","key":"18_CR21","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1167\/iovs.15-16554","volume":"56","author":"S Vujosevic","year":"2015","unstructured":"Vujosevic S, Micera A, Bini S, Berton M, Esposito G, Midena E (2015) Aqueous humor biomarkers of M\u00fcller cell activation in diabetic eyes. Invest Ophthalmol Vis Sci 56(6):3913\u20133918. https:\/\/doi.org\/10.1167\/iovs.15-16554","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"18_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/aos.12812","volume":"94","author":"S Vujosevic","year":"2016","unstructured":"Vujosevic S, Micera A, Bini S, Berton M, Esposito G, Midena E (2016) Proteome analysis of retinal glia cells-related inflammatory cytokines in the aqueous humour of diabetic patients. Acta Ophthalmol 94(1):56\u201364. https:\/\/doi.org\/10.1111\/aos.12812","journal-title":"Acta Ophthalmol"},{"key":"18_CR23","first-page":"254","volume":"22","author":"J Wang","year":"2016","unstructured":"Wang J, He C, Zhou T, Huang Z, Zhou L, Liu X (2016) NGF increases VEGF expression and promotes cell proliferation via ERK1\/2 and AKT signaling in M\u00fcller cells. Mol Vis 22:254\u2013263. eCollection 2016","journal-title":"Mol Vis"},{"issue":"1","key":"18_CR24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12886-019-1142-x","volume":"19","author":"L Zhang","year":"2019","unstructured":"Zhang L, Li X, Lin X, Wu M (2019) Nerve growth factor promotes the proliferation of M\u00fcller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-a\/PI3K\/Akt pathway. BMC Ophthalmol 19(1):130. https:\/\/doi.org\/10.1186\/s12886-019-1142-x","journal-title":"BMC Ophthalmol"},{"issue":"10","key":"18_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109418","volume":"9","author":"F Zhou","year":"2014","unstructured":"Zhou F, Zhang Y, Chen D et al (2014) Potential role of Cyr61 induced degeneration of human M\u00fcller cells in diabetic retinopathy. PLoS One 9(10):e109418. https:\/\/doi.org\/10.1371\/journal.pone.0109418","journal-title":"PLoS One"}],"container-title":["Advances in Experimental Medicine and Biology","Recent Advances in NGF and Related Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-74046-7_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T18:06:23Z","timestamp":1630087583000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-74046-7_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030740450","9783030740467"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-74046-7_18","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"28 August 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}