{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:27:54Z","timestamp":1763728074824,"version":"3.40.3"},"publisher-location":"Cham","reference-count":175,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030783105"},{"type":"electronic","value":"9783030783112"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-78311-2_2","type":"book-chapter","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T13:55:25Z","timestamp":1633874125000},"page":"17-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetics and Diagnostic Approach to Lymphoblastic Leukemia\/Lymphoma"],"prefix":"10.1007","author":[{"given":"Michelle","family":"Afkhami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feras","family":"Ally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Pullarkat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju K.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"key":"2_CR1","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al (2017) WHO classification of tumors of haematopoietic and lymphoid tissues, revised 4th edn. IARC, Lyon, France"},{"issue":"4","key":"2_CR2","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1182\/blood-2014-09-595744","volume":"125","author":"V Perez-Andreu","year":"2015","unstructured":"Perez-Andreu V, Roberts KG, Xu H et al (2015) A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Blood 125(4):680\u2013686. https:\/\/doi.org\/10.1182\/blood-2014-09-595744","journal-title":"Blood"},{"issue":"2","key":"2_CR3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1158\/1055-9965.EPI-07-2949","volume":"18","author":"ST Pullarkat","year":"2009","unstructured":"Pullarkat ST, Danley K, Bernstein L, Brynes RK, Cozen W (2009) High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in California. Cancer Epidemiol Biomarkers Prev 18(2):611\u2013615. https:\/\/doi.org\/10.1158\/1055-9965.EPI-07-2949","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"16","key":"2_CR4","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1056\/NEJMra1400972","volume":"373","author":"SP Hunger","year":"2015","unstructured":"Hunger SP, Mullighan CG (2015) Acute lymphoblastic leukemia in children. N Engl J Med 373(16):1541\u20131552. https:\/\/doi.org\/10.1056\/NEJMra1400972","journal-title":"N Engl J Med"},{"issue":"3","key":"2_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1089\/jayao.2015.0014","volume":"4","author":"N Boissel","year":"2015","unstructured":"Boissel N, Sender LS (2015) Best practices in adolescent and young adult patients with acute lymphoblastic leukemia: a focus on asparaginase. J Adolesc Young Adult Oncol 4(3):118\u2013128. https:\/\/doi.org\/10.1089\/jayao.2015.0014","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"24","key":"2_CR6","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1200\/JCO.2009.26.9456","volume":"28","author":"DA Thomas","year":"2010","unstructured":"Thomas DA, O\u2019Brien S, Faderl S et al (2010) Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. J Clin Oncol 28(24):3880\u20133889. https:\/\/doi.org\/10.1200\/JCO.2009.26.9456","journal-title":"J Clin Oncol"},{"issue":"4","key":"2_CR7","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1182\/blood-2007-10-116582","volume":"111","author":"AH Goldstone","year":"2008","unstructured":"Goldstone AH, Richards SM, Lazarus HM et al (2008) In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation\/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII\/ECOG E2993). Blood 111(4):1827\u20131833. https:\/\/doi.org\/10.1182\/blood-2007-10-116582","journal-title":"Blood"},{"issue":"12","key":"2_CR8","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/ng.2803","volume":"45","author":"V Perez-Andreu","year":"2013","unstructured":"Perez-Andreu V, Roberts KG, Harvey RC et al (2013) Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet 45(12):1494\u20131498. https:\/\/doi.org\/10.1038\/ng.2803","journal-title":"Nat Genet"},{"key":"2_CR9","unstructured":"Appelbaum FR. Chapter 98: Acute Leukemias in Adults. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE (eds) (2014) Abeloff\u2019s clinical oncology, 5th edn. Elsevier, Philadelphia, PA"},{"key":"2_CR10","unstructured":"Jain N, Gurbuxani S, Rhee C, Stock W. Chapter 65: Acute Lymphoblastic Leukemia in Adults. In: Hoffman R, Benz EJ, Silberstein LE, Heslop H, Weitz J, Anastasi J (eds) (2013) Hematology: basic principles and practice, 6th edn. Elsevier, Philadelphia, PA"},{"key":"2_CR11","unstructured":"National Cancer Institute (2018) Childhood Acute Lymphoblastic Leukemia Treatment (PDQ\u00ae). www.cancer.gov\/types\/leukemia\/patient\/child-all-treatment-pdq. Accessed 19 July 2018"},{"key":"2_CR12","unstructured":"National Cancer Institute (2018) SEER Cancer Stat Facts: Acute Lymphocytic Leukemia (ALL). https:\/\/seer.cancer.gov\/statfacts\/html\/alyl.html. Accessed July 18 2018"},{"issue":"10","key":"2_CR13","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3324\/haematol.2018.200311","volume":"103","author":"JM Ribera","year":"2018","unstructured":"Ribera JM (2018) Therapy-related acute lymphoblastic leukemia. Haematologica 103(10):1581\u20131583. https:\/\/doi.org\/10.3324\/haematol.2018.200311","journal-title":"Haematologica"},{"key":"2_CR14","doi-asserted-by":"crossref","unstructured":"Moorman AV (2012) The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Rev 26(3)","DOI":"10.1016\/j.blre.2012.01.001"},{"issue":"2","key":"2_CR15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1182\/blood-2009-07-232124","volume":"115","author":"AV Moorman","year":"2010","unstructured":"Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ (2010) A population-based cytogenetic study of adults with acute lymphoblastic leukemia. Blood 115(2):206\u2013214","journal-title":"Blood"},{"key":"2_CR16","doi-asserted-by":"crossref","unstructured":"Glei\u00dfner B, G\u00f6kbuget N, Bartram CR, Janssen B, Rieder H, Janssen JWG, Fonatsch C, Heyll A, Voliotis D, Beck J, Lipp T, Munzert G, Maurer J, Hoelzer D, Thiel E, the German Multicenter Trials of Adult Acute Lymphoblastic Leukemia Study Group (2002) Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. Blood 99(5):1536\u20131543","DOI":"10.1182\/blood.V99.5.1536"},{"key":"2_CR17","doi-asserted-by":"crossref","unstructured":"Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome (1996) A Collaborative Study of the Group Fran\u00e7ais de Cytog\u00e9n\u00e9tique H\u00e9matologique [published correction appears in Blood 1996 Oct 1;88(7):2818]. Blood 87(8):3135\u20133142","DOI":"10.1182\/blood.V87.8.3135.bloodjournal8783135"},{"issue":"12","key":"2_CR18","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1182\/blood.V80.12.2983.2983","volume":"80","author":"CA Westbrook","year":"1992","unstructured":"Westbrook CA, Hooberman AL, Spino C et al (1992) Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a cancer and leukemia group B Study (8762). Blood 80(12):2983\u20132990","journal-title":"Blood"},{"issue":"3","key":"2_CR19","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/BF02981952","volume":"73","author":"M Sattler","year":"2001","unstructured":"Sattler M, Griffin JD (2001) Mechanisms of transformation by the BCR\/ABL oncogene. Int J Hematol 73(3):278\u2013291","journal-title":"Int J Hematol"},{"issue":"4","key":"2_CR20","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1365-2141.2005.05497","volume":"129","author":"CJ Harrison","year":"2005","unstructured":"Harrison CJ, Moorman AV, Barber KE et al (2005) Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK cancer cytogenetics group study. Br J Haematol 129(4):520\u2013530. https:\/\/doi.org\/10.1111\/j.1365-2141.2005.05497","journal-title":"Br J Haematol"},{"issue":"1","key":"2_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3346\/jkms.2005.20.1.36","volume":"20","author":"HY Woo","year":"2005","unstructured":"Woo HY, Kim DW, Park H, Seong KW, Koo HH, Kim SH (2005) Molecular cytogenetic analysis of gene rearrangements in childhood acute lymphoblastic leukemia. J Korean Med Sci 20(1):36\u201341. https:\/\/doi.org\/10.3346\/jkms.2005.20.1.36","journal-title":"J Korean Med Sci"},{"issue":"1","key":"2_CR22","first-page":"96","volume":"95","author":"G Cimino","year":"2000","unstructured":"Cimino G, Elia L, Rapanotti MC et al (2000) A prospective study of residual-disease monitoring of the ALL1\/AF4 transcript in patients with t(4;11) acute lymphoblastic leukemia. Blood 95(1):96\u2013101","journal-title":"Blood"},{"issue":"11","key":"2_CR23","doi-asserted-by":"publisher","first-page":"4917","DOI":"10.1073\/pnas.92.11.4917","volume":"92","author":"TR Golub","year":"1995","unstructured":"Golub TR, Barker GF, Bohlander SK et al (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 92(11):4917\u20134921. https:\/\/doi.org\/10.1073\/pnas.92.11.4917","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR24","doi-asserted-by":"crossref","unstructured":"Borkhardt A, Cazzaniga G, Viehmann S et al (1997) Incidence and clinical relevance of TEL\/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-M\u00fcnster Study Group. Blood 90(2):571\u2013577","DOI":"10.1182\/blood.V90.2.571.571_571_577"},{"issue":"5\u20136","key":"2_CR25","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/10428199609093444","volume":"21","author":"A Rambaldi","year":"1996","unstructured":"Rambaldi A, Attuati V, Bassan R et al (1996) Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1; 19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia. Leuk Lymphoma 21(5\u20136):457\u2013466","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"2_CR26","first-page":"821","volume":"9","author":"PE Devaraj","year":"1995","unstructured":"Devaraj PE, Foroni L, Janossy G, Hoffbrand AV, Secker-Walker LM (1995) Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes. Leukemia 9(5):821\u2013825","journal-title":"Leukemia"},{"key":"2_CR27","doi-asserted-by":"crossref","unstructured":"V, Zenger M, Schnittger S et al (2014) Acute lymphoblastic leukemia with low hypodiploid\/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%. Genes Chromosomes Cancer 53(6):524\u2013536","DOI":"10.1002\/gcc.22163"},{"issue":"8","key":"2_CR28","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1182\/blood-2003-01-0338","volume":"102","author":"ME Ross","year":"2003","unstructured":"Ross ME, Zhou X, Song G et al (2003) Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102(8):2951\u20132959","journal-title":"Blood"},{"issue":"2","key":"2_CR29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1470-2045(08)70339-5","volume":"10","author":"ML Den Boer","year":"2009","unstructured":"Den Boer ML, van Slegtenhorst M, De Menezes RX et al (2009) A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 10(2):125\u2013134. https:\/\/doi.org\/10.1016\/S1470-2045(08)70339-5","journal-title":"Lancet Oncol"},{"key":"2_CR30","doi-asserted-by":"crossref","unstructured":"Comeaux EQ, Mullighan CG (2017) TP53 mutations in hypodiploid acute lymphoblastic leukemia. Cold Spring Harb Perspect Med 7(3):a026286","DOI":"10.1101\/cshperspect.a026286"},{"issue":"3","key":"2_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/ng.2532","volume":"45","author":"L Holmfeldt","year":"2013","unstructured":"Holmfeldt L, Wei L, Diaz-Flores E et al (2013) The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet 45(3):242\u2013252","journal-title":"Nat Genet"},{"issue":"8","key":"2_CR32","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1182\/blood.V73.8.2081.2081","volume":"73","author":"JC Grimaldi","year":"1989","unstructured":"Grimaldi JC, Meeker TC (1989) The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Blood 73(8):2081\u20132085","journal-title":"Blood"},{"issue":"5","key":"2_CR33","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/leu.2013.317","volume":"28","author":"CJ Harrison","year":"2014","unstructured":"Harrison CJ, Moorman AV, Schwab C et al (2014) An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome. Leukemia 28(5):1015\u20131021","journal-title":"Leukemia"},{"issue":"27","key":"2_CR34","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1200\/JCO.2013.49.1308","volume":"31","author":"NA Heerema","year":"2013","unstructured":"Heerema NA, Carroll AJ, Devidas M et al (2013) Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children\u2019s oncology group studies: a report from the children\u2019s oncology group. J Clin Oncol 31(27):3397\u20133402","journal-title":"J Clin Oncol"},{"key":"2_CR35","doi-asserted-by":"crossref","unstructured":"Afkhami M (2019) Philadelphia-like lymphoblastic leukemia: approach to testing in clinical laboratories for diagnosis, prognosis, and therapeutic risk assessment. Adv Mol Pathol 2(1):59\u201364","DOI":"10.1016\/j.yamp.2019.07.004"},{"issue":"7","key":"2_CR36","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1182\/blood-2009-05-218560","volume":"115","author":"H Kang","year":"2010","unstructured":"Kang H, Chen IM, Wilson CS et al (2010) Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood 115(7):1394\u20131405","journal-title":"Blood"},{"key":"2_CR37","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I et al (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446:758\u2013764","journal-title":"Nature"},{"key":"2_CR38","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1200\/JCO.2016.69.0073","volume":"35","author":"KG Roberts","year":"2017","unstructured":"Roberts KG, Gu Z, Payne-Turner D et al (2017) High frequency and poor outcome of Philadelphia chromosome-like acute lymphoblastic leukemia in adults. J Clin Oncol 35:394\u2013401","journal-title":"J Clin Oncol"},{"key":"2_CR39","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/leu.2016.375","volume":"31","author":"SK Tasian","year":"2017","unstructured":"Tasian SK, Hurtz C, Wertheim GB et al (2017) High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL. Leukemia 31:981\u2013984","journal-title":"Leukemia"},{"issue":"11","key":"2_CR40","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","volume":"371","author":"KG Roberts","year":"2014","unstructured":"Roberts KG, Li Y, Payne-turner D et al (2014) Targetable kinase activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 371(11):1005\u20131015","journal-title":"N Engl J Med"},{"issue":"25","key":"2_CR41","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1182\/blood-2016-12-758979","volume":"129","author":"SC Reshmi","year":"2017","unstructured":"Reshmi SC, Harvey RC, Roberts KG et al (2017) Targetable kinase gene fusions in high-risk B-ALL: a study from the children\u2019s oncology group. Blood 129(25):3352\u20133361","journal-title":"Blood"},{"key":"2_CR42","doi-asserted-by":"crossref","unstructured":"Walsh KM, De smith AJ, Chokkalingam AP et al (2013) GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL. Blood 122(19):3385\u20133387","DOI":"10.1182\/blood-2013-08-524124"},{"key":"2_CR43","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1182\/blood-2016-07-726588","volume":"129","author":"N Jain","year":"2017","unstructured":"Jain N, Roberts KG, Jabbour E et al (2017) Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults. Blood 129:572\u2013581","journal-title":"Blood"},{"issue":"7","key":"2_CR44","first-page":"554","volume":"15","author":"J Wells","year":"2017","unstructured":"Wells J, Jain N, Konopleva M (2017) Philadelphia chromosome like acute lymphoblastic leukemia: progress in a new cancer subtype. Clin AdvHematol Oncol 15(7):554\u2013561","journal-title":"Clin AdvHematol Oncol"},{"issue":"4","key":"2_CR45","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1182\/blood-2011-12-389932","volume":"120","author":"SK Tasian","year":"2012","unstructured":"Tasian SK, Doral MY, Borowitz MJ et al (2012) Aberrant STAT5 and PI3K\/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. Blood 120(4):833\u2013842","journal-title":"Blood"},{"issue":"13","key":"2_CR46","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1182\/blood-2009-03-208397","volume":"114","author":"LJ Russell","year":"2009","unstructured":"Russell LJ, Capasso M, Vater I et al (2009) Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood 114(13):2688\u20132698","journal-title":"Blood"},{"issue":"10","key":"2_CR47","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1038\/leu.2012.101","volume":"26","author":"C Palmi","year":"2012","unstructured":"Palmi C, Vendramini E, Silvestri D et al (2012) Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. Leukemia 26(10):2245\u20132253","journal-title":"Leukemia"},{"issue":"26","key":"2_CR48","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1182\/blood-2009-11-256131","volume":"115","author":"G Cario","year":"2010","unstructured":"Cario G, Zimmermann M, Romey R et al (2010) Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood 115(26):5393\u20135397","journal-title":"Blood"},{"issue":"26","key":"2_CR49","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1182\/blood-2009-09-245944","volume":"115","author":"RC Harvey","year":"2010","unstructured":"Harvey RC, Mullighan CG, Chen IM et al (2010) Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic\/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 115(26):5312\u20135321","journal-title":"Blood"},{"issue":"10","key":"2_CR50","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/pbc.24571","volume":"60","author":"Y Yamashita","year":"2013","unstructured":"Yamashita Y, Shimada A, Yamada T et al (2013) IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia. Pediatr Blood Cancer 60(10):1587\u20131592","journal-title":"Pediatr Blood Cancer"},{"issue":"19","key":"2_CR51","doi-asserted-by":"publisher","first-page":"7347","DOI":"10.1158\/0008-5472.CAN-10-1528","volume":"70","author":"JD Roll","year":"2010","unstructured":"Roll JD, Reuther GW (2010) CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis. Cancer Res 70(19):7347\u20137352","journal-title":"Cancer Res"},{"issue":"1","key":"2_CR52","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1073\/pnas.0911726107","volume":"107","author":"A Yoda","year":"2010","unstructured":"Yoda A, Yoda Y, Chiaretti S et al (2010) Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 107(1):252\u2013257","journal-title":"Proc Natl Acad Sci USA"},{"key":"2_CR53","doi-asserted-by":"crossref","unstructured":"Van bodegom D, Zhong J, Kopp N et al (2012) Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2. Blood 120(14):2853\u20132863","DOI":"10.1182\/blood-2012-02-413252"},{"issue":"33","key":"2_CR54","doi-asserted-by":"publisher","first-page":"22872","DOI":"10.18632\/oncotarget.25089","volume":"9","author":"J Sarno","year":"2018","unstructured":"Sarno J, Savino AM, Buracchi C et al (2018) SRC\/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia. Oncotarget 9(33):22872\u201322885","journal-title":"Oncotarget"},{"issue":"2","key":"2_CR55","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1182\/blood-2016-05-707653","volume":"129","author":"SK Tasian","year":"2017","unstructured":"Tasian SK, Teachey DT, Li Y et al (2017) Potent efficacy of combined PI3K\/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 129(2):177\u2013187","journal-title":"Blood"},{"issue":"17","key":"2_CR56","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1182\/blood-2012-03-415448","volume":"120","author":"SL Maude","year":"2012","unstructured":"Maude SL, Tasian SK, Vincent T et al (2012) Targeting JAK1\/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 120(17):3510\u20133518","journal-title":"Blood"},{"issue":"8","key":"2_CR57","doi-asserted-by":"publisher","first-page":"8027","DOI":"10.18632\/oncotarget.24261","volume":"9","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Shi C, Han L et al (2018) Inhibition of mTORC1\/C2 signaling improves anti-leukemia efficacy of JAK\/STAT blockade in rearranged and\/or driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia. Oncotarget 9(8):8027\u20138041","journal-title":"Oncotarget"},{"issue":"3","key":"2_CR58","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1158\/1078-0432.CCR-10-1203","volume":"17","author":"CG Mullighan","year":"2011","unstructured":"Mullighan CG (2011) New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice. Clin Cancer Res 17(3):396\u2013400","journal-title":"Clin Cancer Res"},{"key":"2_CR59","doi-asserted-by":"crossref","unstructured":"Boer JM, Den boer ML (2017) BCR-ABL1-like acute lymphoblastic leukaemia: from bench to bedside. Eur J Cancer 82:203\u2013218","DOI":"10.1016\/j.ejca.2017.06.012"},{"issue":"2","key":"2_CR60","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ccell.2015.12.013","volume":"29","author":"I Iacobucci","year":"2016","unstructured":"Iacobucci I, Li Y, Roberts KG et al (2016) Truncating erythropoietin receptor rearrangements in acute lymphoblastic leukemia. Cancer Cell 29(2):186\u2013200","journal-title":"Cancer Cell"},{"key":"2_CR61","doi-asserted-by":"crossref","unstructured":"Molteni CG, Te kronnie G, Bicciato S et al (2010) PTPN11 mutations in childhood acute lymphoblastic leukemia occur as a secondary event associated with high hyperdiploidy. Leukemia 24(1):232\u2013235","DOI":"10.1038\/leu.2009.200"},{"issue":"9","key":"2_CR62","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.leukres.2006.02.004","volume":"30","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T, Isomura M, Xu Y et al (2006) PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Leuk Res 30(9):1085\u20131089","journal-title":"Leuk Res"},{"issue":"2","key":"2_CR63","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1182\/blood-2003-11-3876","volume":"104","author":"M Tartaglia","year":"2004","unstructured":"Tartaglia M, Martinelli S, Cazzaniga G et al (2004) Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Blood 104(2):307\u2013313","journal-title":"Blood"},{"issue":"3","key":"2_CR64","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/sj.thj.6200169","volume":"3","author":"L Dah\u00e9ron","year":"2002","unstructured":"Dah\u00e9ron L, Brizard F, Millot F, Cividin M, Lacotte L, Guilhot F, Brizard A (2002) E2A\/HLF fusion gene in an acute lymphoblastic leukemia patient with disseminated intravascular coagulation and a normal karyotype. Hematol J 3(3):153\u2013156. https:\/\/doi.org\/10.1038\/sj.thj.6200169 PMID: 12111652","journal-title":"Hematol J"},{"issue":"17","key":"2_CR65","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1056\/NEJMc090454","volume":"360","author":"BC Medeiros","year":"2009","unstructured":"Medeiros BC (2009) Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360(17):1787","journal-title":"N Engl J Med"},{"key":"2_CR66","doi-asserted-by":"crossref","unstructured":"Marke R, Van leeuwen FN, Scheijen B (2018) The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia. Haematologica 103(4):565\u2013574","DOI":"10.3324\/haematol.2017.185603"},{"key":"2_CR67","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12885-016-2300-7","volume":"16","author":"QM Yao","year":"2016","unstructured":"Yao QM, Liu KY, Gale RP et al (2016) Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia. BMC Cancer 16:269","journal-title":"BMC Cancer"},{"key":"2_CR68","doi-asserted-by":"crossref","unstructured":"Lana T, De lorenzo P, Bresolin S et al (2015) Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia. Leukemia 29(10):2107\u20132110","DOI":"10.1038\/leu.2015.78"},{"key":"2_CR69","doi-asserted-by":"crossref","unstructured":"Mullighan CG (2012) The molecular genetic makeup of acute lymphoblastic leukemia. Hematol Am Soc Hematol Educ Program 389\u2013396","DOI":"10.1182\/asheducation.V2012.1.389.3798360"},{"issue":"5","key":"2_CR70","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1056\/NEJMoa0808253","volume":"360","author":"CG Mullighan","year":"2009","unstructured":"Mullighan CG, Su X, Zhang J et al (2009) Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360(5):470\u2013480","journal-title":"N Engl J Med"},{"issue":"1","key":"2_CR71","first-page":"1","volume":"3","author":"P Kastner","year":"2013","unstructured":"Kastner P, Dupuis A, Gaub MP, Herbrecht R, Lutz P, Chan S (2013) Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia. Am J Blood Res 3(1):1\u201313","journal-title":"Am J Blood Res"},{"issue":"9","key":"2_CR72","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.1182\/blood-2007-09-112631","volume":"112","author":"I Iacobucci","year":"2008","unstructured":"Iacobucci I, Lonetti A, Messa F et al (2008) Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood 112(9):3847\u20133855","journal-title":"Blood"},{"key":"2_CR73","doi-asserted-by":"crossref","unstructured":"Iacobucci I, Iraci N, Messina M et al (2012) IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS ONE 7(7):e40934","DOI":"10.1371\/journal.pone.0040934"},{"issue":"12","key":"2_CR74","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1200\/JCO.1999.17.12.3753","volume":"17","author":"L Sun","year":"1999","unstructured":"Sun L, Goodman PA, Wood CM et al (1999) Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia. J Clin Oncol 17(12):3753\u20133766","journal-title":"J Clin Oncol"},{"issue":"24","key":"2_CR75","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1182\/blood-2014-01-547695","volume":"123","author":"K Beldjord","year":"2014","unstructured":"Beldjord K, Chevret S, Asnafi V et al (2014) Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia. Blood 123(24):3739\u20133749","journal-title":"Blood"},{"issue":"19","key":"2_CR76","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1200\/JCO.2003.10.116","volume":"21","author":"JM Goldberg","year":"2003","unstructured":"Goldberg JM, Silverman LB, Levy DE et al (2003) Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. J Clin Oncol 21(19):3616\u20133622","journal-title":"J Clin Oncol"},{"issue":"12","key":"2_CR77","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1182\/blood.V99.12.4386","volume":"99","author":"MJ Willemse","year":"2002","unstructured":"Willemse MJ, Seriu T, Hettinger K et al (2002) Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL. Blood 99(12):4386\u20134393","journal-title":"Blood"},{"issue":"8","key":"2_CR78","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1182\/blood-2011-03-338707","volume":"118","author":"M Schrappe","year":"2011","unstructured":"Schrappe M, Valsecchi MG, Bartram CR et al (2011) Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study. Blood 118(8):2077\u20132084","journal-title":"Blood"},{"issue":"7","key":"2_CR79","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1200\/JCO.1992.10.7.1078","volume":"10","author":"P Morel","year":"1992","unstructured":"Morel P, Lepage E, Brice P et al (1992) Prognosis and treatment of lymphoblastic lymphoma in adults: a report on 80 patients. J Clin Oncol 10(7):1078\u20131085","journal-title":"J Clin Oncol"},{"key":"2_CR80","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/bjh.12882","volume":"166","author":"K Patrick","year":"2014","unstructured":"Patrick K, Wade R, Goulden N et al (2014) Outcome for children and young people with early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003. Br J Haematol 166:421\u2013424 PMID:24708207","journal-title":"Br J Haematol"},{"issue":"21","key":"2_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V124.21.1.1","volume":"124","author":"BL Wood","year":"2014","unstructured":"Wood BL, Winter SS, Dunsmore KP et al (2014) T-lymphoblastic leukemia (T-ALL) shows excellent outcome, lack of significance of the early thymic precursor (ETP) immune-phenotype, and validation of the prognostic value of end-induction minimal residual disease (MRD) in children\u2019s oncology group (COG) study AALL0434. Blood 124(21):1","journal-title":"Blood"},{"key":"2_CR82","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/bjh.13545","volume":"172","author":"RJ Guo","year":"2016","unstructured":"Guo RJ, Bahmanyar M, Minden MD et al (2016) CD33, not early precursor T-cell phenotype, is associated with adverse outcome in adult T-cell acute lymphoblastic leukemia. Br J Haematol 172:823\u2013825 PMID:26123477","journal-title":"Br J Haematol"},{"key":"2_CR83","first-page":"277","volume":"10","author":"PB Robertson","year":"1997","unstructured":"Robertson PB, Neiman RS, Worapong-paiboon S et al (1997) 013 (CD99) positivity in hematologic proliferations correlates with TdT positivity. Mod Pathol 10:277\u2013282 PMID:9110287","journal-title":"Mod Pathol"},{"key":"2_CR84","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/0046-8177(95)90089-6","volume":"26","author":"R Chetty","year":"1995","unstructured":"Chetty R, Pulford K, Jones M et al (1995) SCL\/TAL-1 expression in T-acute lymphoblastic leukemia: an immunohistochemical and genotypic study. Hum Pathol 26:994\u2013998 PMID:7672800","journal-title":"Hum Pathol"},{"key":"2_CR85","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1046\/j.1365-2141.1998.00807.x","volume":"102","author":"E Delabesse","year":"1998","unstructured":"Delabesse E, Bernard M, Meyer V et al (1998) TAL1 expression does not occur in the majority of T-ALL blasts. Br J Haematol 102:449\u2013457 PMID:9695959","journal-title":"Br J Haematol"},{"key":"2_CR86","doi-asserted-by":"crossref","unstructured":"Pilozzi E, Pulford K, Jones M et al (1998) Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. J Pathol186:140\u2013143. PMID:9924428","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<140::AID-PATH149>3.0.CO;2-Y"},{"key":"2_CR87","doi-asserted-by":"crossref","unstructured":"Khalidi HS, Chang KL, Medeiros LJ et al (1999) Acute lymphoblastic leukemia. Survey of immunophenotype, French-American-British classification, frequency of myeloid antigen expression, and karyotypic abnormaiities in 210 pediatric and adult cases. Am J Ciin Pathol 111:467\u2013476. PMiD:10191766","DOI":"10.1093\/ajcp\/111.4.467"},{"key":"2_CR88","unstructured":"Uckun FM, Bather HN, Gaynon PS et al (1997) Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the children\u2019s cancer group. Blood 90:28\u201335. PMID:9207434"},{"key":"2_CR89","doi-asserted-by":"crossref","unstructured":"Paietta E, Ferrando AA, Neuberg D et al (2004) Activating FLT3 mutations in CD117\/KIT(+) T-cell acute lymphoblastic leukemias. Blood 104:558\u2013560. PMID:15044257","DOI":"10.1182\/blood-2004-01-0168"},{"key":"2_CR90","unstructured":"Bene MC, Castoldi G, Knapp W et al (1995) Proposals for the immunological classification of acute leukemias. Leukemia 9:1783\u20131786, PMID:7564526"},{"key":"2_CR91","doi-asserted-by":"crossref","unstructured":"Weng AP, Ferrando AA, Lee W et al (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306:269\u2013271. PMID:15472075","DOI":"10.1126\/science.1102160"},{"key":"2_CR92","doi-asserted-by":"crossref","unstructured":"Weng AP, Millholland JM, Yashiro-Ohtani Y et al (2006) c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma. Genes Dev 20:2096\u20132109. PMID:16847353","DOI":"10.1101\/gad.1450406"},{"key":"2_CR93","doi-asserted-by":"crossref","unstructured":"Zhu YM, Zhao WL, Fu JF et al (2006) NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res 12:3043\u20133049, PMID:16707600","DOI":"10.1158\/1078-0432.CCR-05-2832"},{"key":"2_CR94","doi-asserted-by":"crossref","unstructured":"Malyukova A, Dohda T, von der Lehr N et al (2007) The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res 67:5611\u20135616. PMID:17575125","DOI":"10.1158\/0008-5472.CAN-06-4381"},{"key":"2_CR95","doi-asserted-by":"crossref","unstructured":"Van vlierberghe P, Palomero T, Khiabanian H et al (2010) PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet 42(4):338\u2013342","DOI":"10.1038\/ng.542"},{"issue":"1","key":"2_CR96","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/0284186X.2011.592148","volume":"51","author":"NJ Yoo","year":"2012","unstructured":"Yoo NJ, Kim YR, Lee SH (2012) Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma. Acta Oncol 51(1):107\u2013111","journal-title":"Acta Oncol"},{"issue":"12","key":"2_CR97","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.3324\/haematol.2011.043083","volume":"96","author":"Q Wang","year":"2011","unstructured":"Wang Q, Qiu H, Jiang H et al (2011) Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia. Haematologica 96(12):1808\u20131814","journal-title":"Haematologica"},{"issue":"1","key":"2_CR98","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3892\/ol.2016.4581","volume":"12","author":"M Li","year":"2016","unstructured":"Li M, Xiao L, Xu J et al (2016) Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia. Oncol Lett 12(1):16\u201322","journal-title":"Oncol Lett"},{"key":"2_CR99","doi-asserted-by":"crossref","unstructured":"Van vlierberghe P, Ferrando A (2012) The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest 122(10):3398\u20133406","DOI":"10.1172\/JCI61269"},{"issue":"40","key":"2_CR100","doi-asserted-by":"publisher","first-page":"65485","DOI":"10.18632\/oncotarget.11796","volume":"7","author":"JF Spinella","year":"2016","unstructured":"Spinella JF, Cassart P, Richer C et al (2016) Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations. Oncotarget 7(40):65485\u201365503","journal-title":"Oncotarget"},{"issue":"4","key":"2_CR101","doi-asserted-by":"publisher","first-page":"366","DOI":"10.4274\/tjh.2017.0194","volume":"34","author":"X Zhou","year":"2017","unstructured":"Zhou X, Gu Y, Han Q, Soliman M, Song C, Ge Z (2017) Coexistence of EZH2, NOTCH1, IL7R, and PHF6 mutations in Adult T-cell acute lymphoblastic leukemia. Turk J Haematol 34(4):366\u2013368","journal-title":"Turk J Haematol"},{"issue":"21","key":"2_CR102","first-page":"2514","volume":"122","author":"T Mori","year":"2016","unstructured":"Mori T, Nagata Y, Makishima H et al (2016) Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms. Leukemia 122(21):2514","journal-title":"Leukemia"},{"issue":"1","key":"2_CR103","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/leu.2010.247","volume":"25","author":"P Van Vlierberghe","year":"2011","unstructured":"Van Vlierberghe P, Patel J, Abdel-Wahab O et al (2011) PHF6 mutations in adult acute myeloid leukemia. Leukemia 25(1):130\u2013134","journal-title":"Leukemia"},{"issue":"4","key":"2_CR104","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1084\/jem.20072182","volume":"205","author":"E Flex","year":"2008","unstructured":"Flex E, Petrangeli V, Stella L et al (2008) Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med 205(4):751\u2013758","journal-title":"J Exp Med"},{"issue":"23","key":"2_CR105","doi-asserted-by":"publisher","first-page":"9414","DOI":"10.1073\/pnas.0811761106","volume":"106","author":"CG Mullighan","year":"2009","unstructured":"Mullighan CG, Zhang J, Harvey RC et al (2009) JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 106(23):9414\u20139418","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9648","key":"2_CR106","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/S0140-6736(08)61342-2","volume":"372","author":"CG Mullighan","year":"2008","unstructured":"Mullighan CG (2008) JAK2- a new player in acute lymphoblastic leukemia. Lancet 372(9648):1448\u20131450","journal-title":"Lancet"},{"key":"2_CR107","doi-asserted-by":"crossref","unstructured":"Greenplate A, Wang K, Tripathi RM et al (2018) Genomic profiling of T-cell neoplasms reveals frequent JAK1 and JAK3 mutations with clonal evasion from targeted therapies. JCO Precis Oncol","DOI":"10.1200\/PO.17.00019"},{"issue":"16","key":"2_CR108","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1182\/blood-2009-09-245498","volume":"115","author":"T Hornakova","year":"2010","unstructured":"Hornakova T, Chiaretti S, Lemaire MM et al (2010) ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon. Blood 115(16):3287\u20133295","journal-title":"Blood"},{"key":"2_CR109","doi-asserted-by":"crossref","unstructured":"Coustan-Smith E, Mullighan CG, Onciu M et al (2009) Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 10:147\u2013156. PMID:19147408","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"2_CR110","doi-asserted-by":"crossref","unstructured":"Zhang J, Ding L, Hoimfeldt L et al (2012) The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481:157\u2013163. PMID:22237106","DOI":"10.1038\/nature10725"},{"key":"2_CR111","doi-asserted-by":"crossref","unstructured":"Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A et al (2011) ETV6 mutations in early immature human T cell leukemias. J Exp Med 208:2571\u20132579. PMID:22162831","DOI":"10.1084\/jem.20112239"},{"key":"2_CR112","doi-asserted-by":"crossref","unstructured":"Neumann M, Coskun E, Fransecky L et al (2013) FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors. PLoS One 8:e53190. PMID:23359050","DOI":"10.1371\/journal.pone.0053190"},{"key":"2_CR113","doi-asserted-by":"crossref","unstructured":"Neumann M, Heesch S, Schlee C et al (2013) Whole-exome sequencing in adult ETP- ALL reveals a high rate of DNMT3A mutations. Blood 121:4749\u20134752. PMID:23603912","DOI":"10.1182\/blood-2012-11-465138"},{"key":"2_CR114","doi-asserted-by":"crossref","unstructured":"Graux C, Cools J, Michaux L et al (2006) Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 20:1496\u20131510. PMID:16826225","DOI":"10.1038\/sj.leu.2404302"},{"key":"2_CR115","doi-asserted-by":"crossref","unstructured":"Han X, Bueso-Ramos CE (2007) Precursor T-cell acute lymphoblastic leukemia\/lymphoblastic lymphoma and acute biphenotypic leukemias. Am J Clin Pathol 127:528\u2013544. PMID:17369128","DOI":"10.1309\/2QE3A6EKQ8UYDYRC"},{"key":"2_CR116","doi-asserted-by":"crossref","unstructured":"Pilozzi E, Muller-Hermelink HK, Falini B et al (1999) Gene rearrangements in T-cell lymphoblastic lymphoma. J Pathol 188:267\u2013270. PMID:10419594","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<267::AID-PATH357>3.0.CO;2-N"},{"key":"2_CR117","doi-asserted-by":"crossref","unstructured":"Szczepaiiski T, Pongers-Willemse MJ, Langerak AW et al (1999) Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage. Blood 93:4079\u20134085. PMID:10361104","DOI":"10.1182\/blood.V93.12.4079.412k42_4079_4085"},{"key":"2_CR118","unstructured":"De Keersmaecker K, Marynen P, Cools J (2005) Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica 90:1116\u20131127. PMID:16079112"},{"key":"2_CR119","doi-asserted-by":"crossref","unstructured":"Meijerink JP (2010) Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 23:307\u2013318. PMID:21112032","DOI":"10.1016\/j.beha.2010.08.002"},{"key":"2_CR120","doi-asserted-by":"crossref","unstructured":"Van Vlierberghe P, Pieters R, Beverloo HB et al (2008) Molecular-genetic insights in paediatric T-celi acute lymphoblastic leukaemia. Br J Haematol 143:153\u2013168. PMID:18691165","DOI":"10.1111\/j.1365-2141.2008.07314.x"},{"key":"2_CR121","doi-asserted-by":"crossref","unstructured":"Ferrando AA, Neuberg DS, Staunton J et al (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1:75\u201387. PMID:12086890","DOI":"10.1016\/S1535-6108(02)00018-1"},{"issue":"1","key":"2_CR122","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/(SICI)1098-2264(199905)25:1<33::AID-GCC5>3.0.CO;2-3","volume":"25","author":"K Kumon","year":"1999","unstructured":"Kumon K, Kobayashi H, Maseki N et al (1999) Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features. Genes Chromosomes Cancer 25(1):33\u201339","journal-title":"Genes Chromosomes Cancer"},{"key":"2_CR123","doi-asserted-by":"crossref","unstructured":"Carlson KM, Vignon C, Bohlander S, Martinez-climent JA, Le beau MM, Rowley JD (2000) Identification and molecular characterization of CALM\/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia. Leukemia 14(1):100\u2013104","DOI":"10.1038\/sj.leu.2401629"},{"key":"2_CR124","doi-asserted-by":"crossref","unstructured":"Ben abdelali R, Asnafi V, Petit A et al (2013) The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest. Haematologica 98(11):1711\u20131717","DOI":"10.3324\/haematol.2013.086082"},{"issue":"11","key":"2_CR125","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.leukres.2012.07.008","volume":"36","author":"C Borel","year":"2012","unstructured":"Borel C, Dastugue N, Cances-lauwers V et al (2012) PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients. Leuk Res 36(11):1365\u20131369","journal-title":"Leuk Res"},{"key":"2_CR126","doi-asserted-by":"crossref","unstructured":"Lo nigro L, Mirabile E, Tumino M et al (2013) Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia. Leukemia 27(12):2419\u20132421","DOI":"10.1038\/leu.2013.149"},{"issue":"4","key":"2_CR127","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1046\/j.1365-2141.1999.01433.x","volume":"105","author":"M Narita","year":"1999","unstructured":"Narita M, Shimizu K, Hayashi Y et al (1999) Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts. Br J Haematol 105(4):928\u2013937","journal-title":"Br J Haematol"},{"issue":"10","key":"2_CR128","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1073\/pnas.93.10.4804","volume":"93","author":"MH Dreyling","year":"1996","unstructured":"Dreyling MH, Martinez-climent JA, Zheng M, Mao J, Rowley JD, Bohlander SK (1996) The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci USA 93(10):4804\u20134809","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"2_CR129","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","volume":"371","author":"KG Roberts","year":"2014","unstructured":"Roberts KG, Li Y, Payne-turner D et al (2014) Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 371(11):1005\u20131015","journal-title":"N Engl J Med"},{"issue":"10","key":"2_CR130","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ng1425","volume":"36","author":"C Graux","year":"2004","unstructured":"Graux C, Cools J, Melotte C et al (2004) Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 36(10):1084\u20131089","journal-title":"Nat Genet"},{"issue":"4","key":"2_CR131","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.3324\/haematol.2015.136499","volume":"101","author":"N Duployez","year":"2016","unstructured":"Duployez N, Grzych G, Ducourneau B et al (2016) NUP214-ABL1 fusion defines a rare subtype of B-cell precursor acute lymphoblastic leukemia that could benefit from tyrosine kinase inhibitors. Haematologica 101(4):e133\u2013e134","journal-title":"Haematologica"},{"key":"2_CR132","doi-asserted-by":"crossref","unstructured":"Giacomini CP, Sun S, Varma S et al (2013) Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet 9(4):e1003464","DOI":"10.1371\/journal.pgen.1003464"},{"issue":"10","key":"2_CR133","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1182\/blood-2006-04-014514","volume":"108","author":"T Burmeister","year":"2006","unstructured":"Burmeister T, G\u00f6kbuget N, Reinhardt R, Rieder H, Hoelzer D, Schwartz S (2006) NUP214-ABL1 in adult T-ALL: the GMALL study group experience. Blood 108(10):3556\u20133559","journal-title":"Blood"},{"key":"2_CR134","doi-asserted-by":"crossref","unstructured":"De keersmaecker K, Porcu M, Cox L et al (2014) NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins. Haematologica 99(1):85\u201393","DOI":"10.3324\/haematol.2013.088674"},{"key":"2_CR135","doi-asserted-by":"crossref","unstructured":"Akin C, Fumo G, Yavuz AS et al (2004) A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood 103:3222\u20133225. PMID:15070706","DOI":"10.1182\/blood-2003-11-3816"},{"key":"2_CR136","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1182\/blood-2018-04-841676","volume":"132","author":"KG Roberts","year":"2018","unstructured":"Roberts KG, Reshmi SC, Harvey RC et al (2018) Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the children\u2019s oncology group. Blood 132:815\u2013824","journal-title":"Blood"},{"issue":"2","key":"2_CR137","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/cncr.31848","volume":"125","author":"S Chiaretti","year":"2019","unstructured":"Chiaretti S, Messina M, Fo\u00e0 R (2019) BCR\/ABL1-like acute lymphoblastic leukemia: how to diagnose and treat? Cancer 125(2):194\u2013204","journal-title":"Cancer"},{"issue":"11","key":"2_CR138","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.bbmt.2009.07.003","volume":"15","author":"AS Stein","year":"2009","unstructured":"Stein AS, Palmer JM, O\u2019Donnell MR et al (2009) Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia. Biol Blood Marrow Transplant 15(11):1407\u20131414","journal-title":"Biol Blood Marrow Transplant"},{"key":"2_CR139","unstructured":"Chalandon Y, Thomas X, Hayette S et al (2015) Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia [published correction appears in Blood. 2015 Sep 3;126(10):1261].\u00a0Blood 125(24):3711\u20133719"},{"issue":"22","key":"2_CR140","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1182\/blood-2010-02-266551","volume":"116","author":"M Mohty","year":"2010","unstructured":"Mohty M, Labopin M, Volin L et al (2010) Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for blood and marrow transplantation. Blood 116(22):4439\u20134443","journal-title":"Blood"},{"issue":"15","key":"2_CR141","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1002\/cncr.28136","volume":"119","author":"H Kantarjian","year":"2013","unstructured":"Kantarjian H, Thomas D, Jorgensen J et al (2013) Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. Cancer 119(15):2728\u20132736","journal-title":"Cancer"},{"issue":"7","key":"2_CR142","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/cncr.21776","volume":"106","author":"DA Thomas","year":"2006","unstructured":"Thomas DA, Faderl S, O\u2019Brien S et al (2006) Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Cancer 106(7):1569\u20131580","journal-title":"Cancer"},{"key":"2_CR143","doi-asserted-by":"crossref","unstructured":"Steeghs EMP, Jerchel IS, De goffau-nobel W et al (2017) JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia. Oncotarget 8(52):89923\u201389938","DOI":"10.18632\/oncotarget.21027"},{"issue":"1","key":"2_CR144","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/leu.2015.202","volume":"30","author":"AM Roncero","year":"2016","unstructured":"Roncero AM, L\u00f3pez-nieva P, Cobos-fern\u00e1ndez MA et al (2016) Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia 30(1):94\u2013103","journal-title":"Leukemia"},{"key":"2_CR145","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cancergen.2017.07.008","volume":"216\u2013217","author":"T Sadras","year":"2017","unstructured":"Sadras T, Heatley SL, Kok CH et al (2017) A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH. Cancer Genet 216\u2013217:86\u201390","journal-title":"Cancer Genet"},{"issue":"18","key":"2_CR146","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1101\/gad.284109.116","volume":"30","author":"D Hu","year":"2016","unstructured":"Hu D, Shilatifard A (2016) Epigenetics of hematopoiesis and hematological malignancies. Genes Dev 30(18):2021\u20132041","journal-title":"Genes Dev"},{"key":"2_CR147","doi-asserted-by":"crossref","unstructured":"Ruault M, Brun ME, Ventura M, Roiz\u00e8s G, De sario A (2002) MLL3, a new human member of the TRX\/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. Gene 284(1\u20132):73\u201381","DOI":"10.1016\/S0378-1119(02)00392-X"},{"issue":"6","key":"2_CR148","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/nrc3929","volume":"15","author":"RC Rao","year":"2015","unstructured":"Rao RC, Dou Y (2015) Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer 15(6):334\u2013346","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"2_CR149","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ccr.2014.03.016","volume":"25","author":"C Chen","year":"2014","unstructured":"Chen C, Liu Y, Rappaport AR et al (2014) MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell 25(5):652\u2013665","journal-title":"Cancer Cell"},{"issue":"5","key":"2_CR150","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.cancergen.2015.01.005","volume":"208","author":"DJ Ford","year":"2015","unstructured":"Ford DJ, Dingwall AK (2015) The cancer COMPASS: navigating the functions of MLL complexes in cancer. Cancer Genet 208(5):178\u2013191","journal-title":"Cancer Genet"},{"issue":"6","key":"2_CR151","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/ejh.12972","volume":"99","author":"S Kayser","year":"2017","unstructured":"Kayser S, Feszler M, Krzykalla J et al (2017) Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients. Eur J Haematol 99(6):544\u2013552","journal-title":"Eur J Haematol"},{"issue":"12","key":"2_CR152","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1128\/MCB.01655-05","volume":"26","author":"MJ Malecki","year":"2006","unstructured":"Malecki MJ, Sanchez-Irizarry C, Mitchell JL et al (2006) Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol 26(12):4642\u20134651","journal-title":"Mol Cell Biol"},{"issue":"5","key":"2_CR153","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00277-012-1664-2","volume":"92","author":"HJ Huh","year":"2013","unstructured":"Huh HJ, Lee SH, Yoo KH et al (2013) Gene mutation profiles and prognostic implications in Korean patients with T-lymphoblastic leukemia. Ann Hematol 92(5):635\u2013644","journal-title":"Ann Hematol"},{"issue":"5","key":"2_CR154","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.18632\/oncotarget.2218","volume":"6","author":"M Neumann","year":"2015","unstructured":"Neumann M, Vosberg S, Schlee C et al (2015) Mutational spectrum of adult T-ALL. Oncotarget 6(5):2754\u20132766","journal-title":"Oncotarget"},{"issue":"5694","key":"2_CR155","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","volume":"306","author":"AP Weng","year":"2004","unstructured":"Weng AP, Ferrando AA, Lee W et al (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306(5694):269\u2013271","journal-title":"Science"},{"issue":"5","key":"2_CR156","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/leu.2012.357","volume":"27","author":"N Villamor","year":"2013","unstructured":"Villamor N, Conde L, Mart\u00ednez-trillos A et al (2013) NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 27(5):1100\u20131106","journal-title":"Leukemia"},{"issue":"3","key":"2_CR157","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3324\/haematol.2012.061721","volume":"97","author":"V Gianfelici","year":"2012","unstructured":"Gianfelici V (2012) Activation of the NOTCH1 pathway in chronic lymphocytic leukemia. Haematologica 97(3):328\u2013330","journal-title":"Haematologica"},{"issue":"12","key":"2_CR158","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1038\/leu.2013.218","volume":"27","author":"S Weissmann","year":"2013","unstructured":"Weissmann S, Roller A, Jeromin S et al (2013) Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients. Leukemia 27(12):2393\u20132396","journal-title":"Leukemia"},{"key":"2_CR159","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/1471-2407-13-274","volume":"13","author":"K Willander","year":"2013","unstructured":"Willander K, Dutta RK, Ungerb\u00e4ck J et al (2013) NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients. BMC Cancer 13:274","journal-title":"BMC Cancer"},{"issue":"2","key":"2_CR160","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/ng0296-154","volume":"12","author":"T Nakamura","year":"1996","unstructured":"Nakamura T, Largaespada DA, Lee MP et al (1996) Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 12(2):154\u2013158","journal-title":"Nat Genet"},{"issue":"7","key":"2_CR161","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1080\/10428190310001659325","volume":"45","author":"C Slape","year":"2004","unstructured":"Slape C, Aplan PD (2004) The role of NUP98 gene fusions in hematologic malignancy. Leuk Lymphoma 45(7):1341\u20131350","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"2_CR162","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/gcc.20092","volume":"41","author":"YN Kobzev","year":"2004","unstructured":"Kobzev YN, Martinez-climent J, Lee S, Chen J, Rowley JD (2004) Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements. Genes Chromosomes Cancer 41(4):339\u2013352","journal-title":"Genes Chromosomes Cancer"},{"issue":"24","key":"2_CR163","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1182\/blood-2011-07-328880","volume":"118","author":"SM Gough","year":"2011","unstructured":"Gough SM, Slape CI, Aplan PD (2011) NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Blood 118(24):6247\u20136257","journal-title":"Blood"},{"issue":"2","key":"2_CR164","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1182\/blood.V94.2.741","volume":"94","author":"T Nakamura","year":"1999","unstructured":"Nakamura T, Yamazaki Y, Hatano Y, Miura I (1999) NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). Blood 94(2):741\u2013747","journal-title":"Blood"},{"issue":"1","key":"2_CR165","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cancergencyto.2007.09.007","volume":"180","author":"A Petit","year":"2008","unstructured":"Petit A, Radford I, Waill MC, Romana S, Berger R (2008) NUP98-NSD1 fusion by insertion in acute myeloblastic leukemia. Cancer Genet Cytogenet 180(1):43\u201346","journal-title":"Cancer Genet Cytogenet"},{"key":"2_CR166","doi-asserted-by":"crossref","unstructured":"Hollink IH, Van den heuvel-eibrink MM, Arentsen-peters ST et al (2011) NUP98\/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood 118(13):3645\u20133656","DOI":"10.1182\/blood-2011-04-346643"},{"issue":"6","key":"2_CR167","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1182\/blood.V94.6.2072","volume":"94","author":"DJ Hussey","year":"1999","unstructured":"Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A (1999) The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. Blood 94(6):2072\u20132079","journal-title":"Blood"},{"key":"2_CR168","doi-asserted-by":"crossref","unstructured":"Mecucci C, La starza R, Negrini M et al (2000) t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia. Br J Haematol 109(4):788\u2013793","DOI":"10.1046\/j.1365-2141.2000.02106.x"},{"issue":"4","key":"2_CR169","first-page":"436","volume":"86","author":"G Cimino","year":"2001","unstructured":"Cimino G, Sprovieri T, Rapanotti MC, Fo\u00e0 R, Mecucci C, Mandelli F (2001) Molecular evaluation of the NUP98\/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia. Haematologica 86(4):436\u2013437","journal-title":"Haematologica"},{"key":"2_CR170","doi-asserted-by":"crossref","unstructured":"Van zutven LJ, Onen E, Velthuizen SC et al (2006) Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 45(5):437\u2013446","DOI":"10.1002\/gcc.20308"},{"key":"2_CR171","doi-asserted-by":"crossref","unstructured":"Sonoki T, Harder L, Horsman DE et al (2001) Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 98(9):2837\u20132844","DOI":"10.1182\/blood.V98.9.2837"},{"issue":"3","key":"2_CR172","first-page":"729","volume":"8","author":"M Filipits","year":"2002","unstructured":"Filipits M, Jaeger U, Pohl G et al (2002) Cyclin D3 is a predictive and prognostic factor in diffuse large B-cell lymphoma. Clin Cancer Res 8(3):729\u2013733","journal-title":"Clin Cancer Res"},{"issue":"8","key":"2_CR173","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2016-11-751024","volume":"129","author":"S Curiel-olmo","year":"2017","unstructured":"Curiel-olmo S, Mond\u00e9jar R, Almaraz C et al (2017) Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. Blood 129(8):1042\u20131045","journal-title":"Blood"},{"issue":"6","key":"2_CR174","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.3324\/haematol.2016.156885","volume":"102","author":"M Rohde","year":"2017","unstructured":"Rohde M, Bonn BR, Zimmermann M et al (2017) Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-M\u00fcnster protocols. Haematologica 102(6):1091\u20131098","journal-title":"Haematologica"},{"issue":"9","key":"2_CR175","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1158\/1078-0432.CCR-15-2123","volume":"22","author":"RD Morin","year":"2016","unstructured":"Morin RD, Assouline S, Alcaide M et al (2016) Genetic landscapes of relapsed and refractory diffuse large B-cell lymphomas. Clin Cancer Res 22(9):2290\u20132300","journal-title":"Clin Cancer Res"}],"container-title":["Cancer Treatment and Research","Biology and Treatment of Leukemia and Bone Marrow Neoplasms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-78311-2_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T14:57:38Z","timestamp":1633877858000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-78311-2_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030783105","9783030783112"],"references-count":175,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-78311-2_2","relation":{},"ISSN":["0927-3042","2509-8497"],"issn-type":[{"type":"print","value":"0927-3042"},{"type":"electronic","value":"2509-8497"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"10 October 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}