{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T18:43:37Z","timestamp":1742928217574,"version":"3.40.3"},"publisher-location":"Cham","reference-count":18,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030845315"},{"type":"electronic","value":"9783030845322"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-84532-2_22","type":"book-chapter","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T23:03:52Z","timestamp":1628463832000},"page":"242-252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Mechanism of Cistanche in the Treatment of Colorectal Cancer Based on Network Pharmacology"],"prefix":"10.1007","author":[{"given":"Yuan","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxia","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zibai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"22_CR1","unstructured":"40, 601\u2013625 (2020)"},{"key":"22_CR2","unstructured":"Song, Z.H., Lei, L., Tup, F.: Advances in research of pharmacological activity in plants of Cistanche Hoffing.et Link. Chin. Tradit. Herb. Drugs 34, 16\u201318 (2003)"},{"key":"22_CR3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.ijbiomac.2020.01.216","volume":"149","author":"Z Fu","year":"2020","unstructured":"Fu, Z., Han, L., Peng, Z., et al.: Cistanche polysaccharides enhance echinacoside absorption in vivo and affect the gut microbiota. Int. J. Biol. Macromol. 149, 732\u2013740 (2020)","journal-title":"Int. J. Biol. Macromol."},{"key":"22_CR4","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ijbiomac.2005.11.001","volume":"37","author":"XM Wu","year":"2005","unstructured":"Wu, X.M., Gao, X.M., Tsim, K.W., et al.: An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes. Int. J. Biol. Macromol. 37, 278\u2013282 (2005)","journal-title":"Int. J. Biol. Macromol."},{"key":"22_CR5","doi-asserted-by":"publisher","first-page":"e0191356","DOI":"10.1371\/journal.pone.0191356","volume":"13","author":"A Zhang","year":"2018","unstructured":"Zhang, A., Yang, X., Li, Q., et al.: Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo. PLOS One 13, e0191356 (2018)","journal-title":"PLOS One"},{"key":"22_CR6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.biopha.2016.08.028","volume":"83","author":"H Luo","year":"2016","unstructured":"Luo, H., Cao, R., Wang, L., Zhu, L.: Protective effect of Cistanchis A on ethanol-induced damage in primary cultured mouse hepatocytes. Biomed Pharmacother. 83, 1071\u20131079 (2016)","journal-title":"Biomed Pharmacother."},{"key":"22_CR7","doi-asserted-by":"crossref","unstructured":"Jia, Y., Guan, Q., Guo, Y., et al.: Reduction of inflammatory hyperplasia in the intestine in colon cancer\u2010prone mice by water-extract of cistanche deserticola. 26, 812\u2013819 (2012)","DOI":"10.1002\/ptr.3637"},{"key":"22_CR8","unstructured":"47, 2938\u20132942 (2016)"},{"key":"22_CR9","doi-asserted-by":"crossref","unstructured":"Fan, Y., Ma, Z., Zhao, L.L., et al.: Anti-tumor activities and mechanisms of Traditional Chinese medicines formulas: a review. 132 (2020)","DOI":"10.1016\/j.biopha.2020.110820"},{"key":"22_CR10","doi-asserted-by":"crossref","unstructured":"Ezzati, M., Yousefi, B., Velaei, K., et al.: A review on anti-cancer properties of quercetin in breast cancer. Life Sci. 248, 117463 (2020)","DOI":"10.1016\/j.lfs.2020.117463"},{"key":"22_CR11","unstructured":"49, 4678 (2018)"},{"key":"22_CR12","doi-asserted-by":"crossref","unstructured":"Backhouse, N., Rosales, L., Apablaza, C., et al.: Analgesic, anti-inflammatory and antioxidant properties of Buddleja globose, Buddlejaceae. J. Ethnopharmacol. 116, 263 (2008)","DOI":"10.1016\/j.jep.2007.11.025"},{"key":"22_CR13","unstructured":"15, 66 (2015)"},{"key":"22_CR14","first-page":"1113","volume":"54","author":"T Morisaki","year":"1994","unstructured":"Morisaki, T., Uchiyama, A., Yuzuki, D., et al.: Interleukin 4 regulates G1 cell cycle progression in gastric carcinoma cells. Cancer Res. 54, 1113\u20131118 (1994)","journal-title":"Cancer Res."},{"key":"22_CR15","unstructured":"1, 52\u201357.12 (2016)"},{"key":"22_CR16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3748\/wjg.v21.i1.84","volume":"21","author":"X Li","year":"2015","unstructured":"Li, X., Zhou, J., Chen, Z., et al.: p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation. World J. Gastroenterol. 21, 84\u201393 (2015)","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"22_CR17","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"A Hopkins","year":"2007","unstructured":"Hopkins, A.: Network pharmacology. Nat Biotechnol. 25(10), 1110\u20131111 (2007)","journal-title":"Nat Biotechnol."},{"key":"22_CR18","first-page":"696","volume":"47","author":"ZH Liu","year":"2012","unstructured":"Liu, Z.H., Sun, X., et al.: Network pharmacology: new opportunity for the modernization of traditional Chinese medicine. Acta Pharm. Sin. 47, 696\u2013703 (2012)","journal-title":"Acta Pharm. Sin."}],"container-title":["Lecture Notes in Computer Science","Intelligent Computing Theories and Application"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-84532-2_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T23:07:28Z","timestamp":1628464048000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-84532-2_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030845315","9783030845322"],"references-count":18,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-84532-2_22","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"9 August 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ICIC","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Intelligent Computing","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Shenzhen","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"China","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2021","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"12 August 2021","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"15 August 2021","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"17","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"icic2021a","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/www.ic-icc.cn\/2021\/index.htm","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}