{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:03:39Z","timestamp":1790953419587,"version":"4.1.0"},"publisher-location":"Cham","reference-count":98,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030856854","type":"print"},{"value":"9783030856861","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-030-85686-1_13","type":"book-chapter","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T06:02:47Z","timestamp":1637560967000},"page":"263-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Functional Molecules of Intestinal Mucosal Products and Peptones\u00a0in Animal Nutrition and Health"],"prefix":"10.1007","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"13_CR1","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.2741\/3413","volume":"14","author":"R Al-Sadi","year":"2009","unstructured":"Al-Sadi R, Boivin M, Ma T (2009) Mechanism of cytokine modulation of epithelial tight junction barrier. Front Biosci 14:2765\u20132778","journal-title":"Front Biosci"},{"key":"13_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0031-9384(03)00215-4","volume":"80","author":"K Angers","year":"2003","unstructured":"Angers K, Haddad N, Selmaoui B, Thibault L (2003) Effect of melatonin on total food intake and macronutrient choice in rats. Physiol Behav 80:9\u201318","journal-title":"Physiol Behav"},{"key":"13_CR3","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1186\/2193-1801-3-474","volume":"3","author":"H Assaad","year":"2014","unstructured":"Assaad H, Zhou L, Carroll RJ, Wu G (2014) Rapid publication-ready MS-Word tables for one-way ANOVA. SpringerPlus 3:474","journal-title":"Springerplus"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-54462-1_1","volume":"1285","author":"FW Bazer","year":"2021","unstructured":"Bazer FW, Seo H, Johnson GA, Wu G (2021) One-carbon metabolism and development of the conceptus during pregnancy: lessons from studies with sheep and pigs. Adv Exp Med Biol 1285:1\u201315","journal-title":"Adv Exp Med Biol"},{"key":"13_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-45328-2_1","volume":"1265","author":"M Beaumont","year":"2020","unstructured":"Beaumont M, Blachier F (2020) Amino acids in intestinal physiology and health. Adv Exp Med Biol 1265:1\u201320","journal-title":"Adv Exp Med Biol"},{"key":"13_CR6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrmicro2546","volume":"9","author":"CL Bevins","year":"2011","unstructured":"Bevins CL, Salzman NH (2011) Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nature Rev Microbiol 9:356\u2013368","journal-title":"Nature Rev Microbiol"},{"key":"13_CR7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jn\/131.3.709","volume":"131","author":"DG Burrin","year":"2001","unstructured":"Burrin DG, Petersen Y, Stoll B, Sangild P (2001) Glucagon-like peptide 2: a nutrient-responsive gut growth factor. J Nutr 131:709\u2013712","journal-title":"J Nutr"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-3-030-54462-1_11","volume":"1285","author":"DS Che","year":"2021","unstructured":"Che DS, Nyingwa PS, Ralinala KM, Maswanganye GMT, Wu G (2021) Amino acids in the nutrition, metabolism, and health of domestic cats. Adv Exp Med Biol 1285:217\u2013231","journal-title":"Adv Exp Med Biol"},{"key":"13_CR90","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1093\/jn\/nxab058","volume":"151","author":"JQ Chen","year":"2021","unstructured":"Chen JQ, Yang YC, Yang C, Dai ZL, Kim IH, Wu G, Wu ZL (2021) Dietary supplementation with glycine enhances intestinal mucosal integrity and ameliorates inflammation in C57BL\/6J mice with high-fat diet-induced obesity. J Nutr 151:1769\u20131778","journal-title":"J Nutr"},{"key":"13_CR9","unstructured":"Cromwell GL (2006) Rendered products in swine nutrition. In: Meeker DL and Hamilton CR (eds) Essential Rendering National renderers association, Alexandria, VA, USA. pp 141\u2013157"},{"key":"13_CR10","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.2741\/3820","volume":"16","author":"ZL Dai","year":"2011","unstructured":"Dai ZL, Wu G, Zhu WY (2011) Amino acid metabolism in intestinal bacteria: links between gut ecology and host health. Front Biosci 16:1768\u20131786","journal-title":"Front Biosci"},{"key":"13_CR11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/00042737-200107000-00002","volume":"13","author":"AU Dignass","year":"2001","unstructured":"Dignass AU, Sturm A (2001) Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol 13:763\u2013770","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"13_CR98","doi-asserted-by":"publisher","unstructured":"Dillon EL, Wu G (2021) Cortisol enhances ctrulline synthesis from proline in enterocytes of suckling piglets. Amino Acids. https:\/\/doi.org\/10.1007\/s00726-021-03039-y","DOI":"10.1007\/s00726-021-03039-y"},{"key":"13_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3748\/wjg.15.385","volume":"15","author":"L Drozdowski","year":"2009","unstructured":"Drozdowski L, Thomson AB (2009) Intestinal hormones and growth factors: effects on the small intestine. World J Gastroenterol 15:385\u2013406","journal-title":"World J Gastroenterol"},{"key":"13_CR13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0014-5793(96)00495-4","volume":"388","author":"B Dvor\u00e1k","year":"1996","unstructured":"Dvor\u00e1k B, Stephana AL, Holubec H, Williams CS, Philipps AF, Koldovsko\u00fd O (1996) Insulin-like growth factor-I (IGF-I) mRNA in the small intestine of suckling and adult rats. FEBS Lett 388:155\u2013160","journal-title":"FEBS Lett"},{"key":"13_CR14","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","volume":"8","author":"YZ Fang","year":"2002","unstructured":"Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 8:872\u2013879","journal-title":"Nutrition"},{"key":"13_CR15","unstructured":"Ferraris RP (1994) Regulation of intestinal nutrient transport. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven Press, New York, pp 1821\u20131844"},{"key":"13_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-3-030-45328-2_6","volume":"1265","author":"NE Flynn","year":"2020","unstructured":"Flynn NE, Shaw MH, Becker JT (2020) Amino acids in health and endocrine function. Adv Exp Med Biol 1265:97\u2013109","journal-title":"Adv Exp Med Biol"},{"key":"13_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev.nutr.27.061406.093726","volume":"27","author":"DW Gietzen","year":"2007","unstructured":"Gietzen DW, Hao S, Anthony TG (2007) Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr 27:63\u201378","journal-title":"Annu Rev Nutr"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-3-030-54462-1_4","volume":"1285","author":"KR Gilbreath","year":"2021","unstructured":"Gilbreath KR, Bazer FW, Satterfield MC, Wu G (2021) Amino acid nutrition and reproductive performance in ruminants. Adv Exp Med Biol 1285:43\u201361","journal-title":"Adv Exp Med Biol"},{"key":"13_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-3-030-74180-8_6","volume":"1332","author":"KM Halloran","year":"2021","unstructured":"Halloran KM, Stenhouse C, Wu G, Bazer FW (2021) Arginine, agmatine and polyamines: key regulators of conceptus development in mammals. Adv Exp Med Biol 1332:85\u2013105","journal-title":"Adv Exp Med Biol"},{"key":"13_CR20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1748-1716.2008.01870.x","volume":"193","author":"MB Hansen","year":"2008","unstructured":"Hansen MB, Witte AB (2008) The role of serotonin in intestinal luminal sensing and secretion. Acta Physiol (oxf) 193:311\u2013323","journal-title":"Acta Physiol (oxf)"},{"key":"13_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0167-0115(92)90538-6","volume":"39","author":"JA Hardin","year":"1992","unstructured":"Hardin JA, Gall DG (1992) The effect of TGF alpha on intestinal solute transport. Regul Pept 39:169\u2013176","journal-title":"Regul Pept"},{"key":"13_CR22","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1152\/physrev.1970.50.3.428","volume":"50","author":"AE Harper","year":"1970","unstructured":"Harper AE, Benevenga NJ, Wohlhueter RM (1970) Effects of ingestion of disproportionate amounts of amino acids. Physiol Rev 50:428\u2013558","journal-title":"Physiol Rev"},{"key":"13_CR23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-3-030-45328-2_10","volume":"1265","author":"WL He","year":"2020","unstructured":"He WL, Wu G (2020) Metabolism of amino acids in the brain and their roles in regulating food intake. Adv Exp Med Biol 1265:167\u2013185","journal-title":"Adv Exp Med Biol"},{"key":"13_CR24","doi-asserted-by":"crossref","unstructured":"He WL, Li P, Wu G (2021a) Amino acid nutrition and metabolism in chickens. Adv Exp Med Biol 1285:109\u2013131","DOI":"10.1007\/978-3-030-54462-1_7"},{"key":"13_CR25","doi-asserted-by":"crossref","unstructured":"He WL, Furukawa K, Toyomizu M, Nochi T, Bailey CA, Wu G (2021b) Interorgan metabolism, nutritional impacts, and safety of dietary L-glutamate and L-glutamine in poultry. Adv Exp Med Biol 1332:107\u2013128","DOI":"10.1007\/978-3-030-74180-8_7"},{"key":"13_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-3-030-54462-1_12","volume":"1285","author":"CM Herring","year":"2021","unstructured":"Herring CM, Bazer FW, Wu G (2021) Amino acid nutrition for optimum growth, development, reproduction, and health of zoo animals. Adv Exp Med Biol 1285:233\u2013253","journal-title":"Adv Exp Med Biol"},{"key":"13_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3945\/an.116.012971","volume":"8","author":"YQ Hou","year":"2017","unstructured":"Hou YQ, Wu G (2017) Nutritionally nonessential amino acids: a misnomer in nutritional sciences. Adv Nutr 8:137\u2013139","journal-title":"Adv Nutr"},{"key":"13_CR28","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1007\/s00726-018-2634-3","volume":"50","author":"YQ Hou","year":"2018","unstructured":"Hou YQ, Wu G (2018) L-Glutamate nutrition and metabolism in swine. Amino Acids 50:1497\u20131510","journal-title":"Amino Acids"},{"key":"13_CR29","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1177\/1535370215587913","volume":"240","author":"YQ Hou","year":"2015","unstructured":"Hou YQ, Yin YL, Wu G (2015) Dietary essentiality of \u201cnutritionally nonessential amino acids\u201d for animals and humans. Exp Biol Med 240:997\u20131007","journal-title":"Exp Biol Med"},{"key":"13_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3945\/an.115.010850","volume":"7","author":"YQ Hou","year":"2016","unstructured":"Hou YQ, Yao K, Yin YL, Wu G (2016) Endogenous synthesis of amino acids limits growth, lactation and reproduction of animals. Adv Nutr 7:331\u2013342","journal-title":"Adv Nutr"},{"key":"13_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40104-017-0153-9","volume":"8","author":"YQ Hou","year":"2017","unstructured":"Hou YQ, Wu ZL, Dai ZL, Wang GH, Wu G (2017) Protein hydrolysates in animal nutrition: industrial production, bioactive peptides, and functional significance. J Anim Sci Biotechnol 8:24","journal-title":"J Anim Sci Biotechnol"},{"key":"13_CR32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-4939-7398-9_10","volume":"1694","author":"YQ Hou","year":"2018","unstructured":"Hou YQ, Li XL, Dai ZL, Wu ZL, Bazer FW, Wu G (2018) Analysis of glutathione in biological samples by HPLC involving pre-column derivatization with o-phthalaldehyde. Methods Mol Biol 1694:105\u2013115","journal-title":"Methods Mol Biol"},{"key":"13_CR33","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00726-019-02751-0","volume":"51","author":"YQ Hou","year":"2019","unstructured":"Hou YQ, He WL, Hu SD, Wu G (2019) Composition of polyamines and amino acids in plant-source foods for human consumption. Amino Acids 51:1153\u20131165","journal-title":"Amino Acids"},{"key":"13_CR91","doi-asserted-by":"publisher","unstructured":"Hu SD, He WL, Wu G (2021) Hydroxyproline in animal metabolism, nutrition, and cell signaling. Amino Acids. https:\/\/doi.org\/10.1007\/s00726-021-03056-x","DOI":"10.1007\/s00726-021-03056-x"},{"key":"13_CR92","doi-asserted-by":"publisher","first-page":"e1800494","DOI":"10.1002\/mnfr.201800494","volume":"62","author":"Y Ji","year":"2018","unstructured":"Ji Y, Dai ZL, Sun S, Ma X, Yang Y, Tso O, Wu G, Wu ZL (2018) Hydroxyproline attenuates dextran sulfate sodium-induced colitis in mice: Involvment of the NF-kB signaling and oxidative stress. Mol Nutr Food Res 62:e1800494","journal-title":"Mol Nutr Food Res"},{"key":"13_CR34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-3-030-74180-8_5","volume":"1332","author":"SC Jia","year":"2021","unstructured":"Jia SC, Li XY, He WL, Wu G (2021) Oxidation of energy substrates in tissues of fish: Metabolic significance and implications for gene expression and carcinogenesis. Adv Exp Med Biol 1332:67\u201383","journal-title":"Adv Exp Med Biol"},{"key":"13_CR001","doi-asserted-by":"crossref","unstructured":"Jia SC, Li XY, He WL, Wu G (2022) Protein-sourced feedstuffs for aquatic animals in nutrition research and aquaculture. Adv\nExp Med Biol 1354:237\u2013261","DOI":"10.1007\/978-3-030-85686-1_12"},{"key":"13_CR35","first-page":"A53","volume":"32","author":"GA Johnson","year":"2011","unstructured":"Johnson GA, Frank JW, Li XL, Bayless KJ, Burghardt RC, Bazer FW, Wu G (2011) Osteopontin expressed at the uterine-placental interface increases ion transport across the pig placenta. Placenta 32:A53","journal-title":"Placenta"},{"key":"13_CR36","doi-asserted-by":"publisher","first-page":"D303","DOI":"10.2741\/A428","volume":"4","author":"MK Jones","year":"1999","unstructured":"Jones MK, Tomikawa M, Mohajer B, Tarnawski AS (1999) Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci 4:D303\u2013D309","journal-title":"Front Biosci"},{"key":"13_CR37","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev.nutr.010308.161202","volume":"28","author":"RC Khanal","year":"2008","unstructured":"Khanal RC, Nemere I (2008) Regulation of intestinal calcium transport. Annu Rev Nutr 28:179\u2013196","journal-title":"Annu Rev Nutr"},{"key":"13_CR38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1017\/S000711450769936X","volume":"98","author":"P Li","year":"2007","unstructured":"Li P, Yin YL, Li DF, Kim SW, Wu G (2007) Amino acids and immune function. Br J Nutr 98:237\u2013252","journal-title":"Br J Nutr"},{"key":"13_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00726-008-0171-1","volume":"37","author":"P Li","year":"2009","unstructured":"Li P, Mai KS, Trushenski J, Wu G (2009) New developments in fish amino acid nutrition: towards functional and environmentally oriented aquafeeds. Amino Acids 37:43\u201353","journal-title":"Amino Acids"},{"key":"13_CR40","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00726-010-0740-y","volume":"40","author":"XL Li","year":"2011","unstructured":"Li XL, Rezaei R, Li P, Wu G (2011) Composition of amino acids in feed ingredients for animal diets. Amino Acids 40:1159\u20131168","journal-title":"Amino Acids"},{"key":"13_CR93","doi-asserted-by":"publisher","first-page":"964","DOI":"10.3945\/jn.115.228312","volume":"146","author":"W Li","year":"2016","unstructured":"Li W, Sun KJ, Ji Y, Wu ZL, Wang W, Dai Z, Wu G (2016) Glycine regulates expression and distribution of claudin-7 and ZO-3 proteins in porcine intestinal epithelial cells. J Nutr 146:964\u2013969","journal-title":"J Nutr"},{"key":"13_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00726-017-2490-6","volume":"50","author":"P Li","year":"2018","unstructured":"Li P, Wu G (2018) Roles of dietary glycine, proline and hydroxyproline in collagen synthesis and animal growth. Amino Acids 50:29\u201338","journal-title":"Amino Acids"},{"key":"13_CR42","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00726-020-02833-4","volume":"52","author":"P Li","year":"2020","unstructured":"Li P, Wu G (2020) Composition of amino acids and related nitrogenous nutrients in feedstuffs for animal diets. Amino Acids 52:523\u2013542","journal-title":"Amino Acids"},{"key":"13_CR43","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00726-020-02851-2","volume":"52","author":"XL Li","year":"2020","unstructured":"Li XL, Zheng SX, Wu G (2020a) Nutrition and metabolism of glutamate and glutamine in fish. Amino Acids 52:671\u2013691","journal-title":"Amino Acids"},{"key":"13_CR44","doi-asserted-by":"crossref","unstructured":"Li XY, Zheng SX, Han T, Song F, Wu G (2020b) Effects of dietary protein intake on the oxidation of glutamate, glutamine, glucose and palmitate in tissues of largemouth bass (Micropterus salmoides) Amino Acids 52:1491\u20131503","DOI":"10.1007\/s00726-020-02907-3"},{"key":"13_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-030-54462-1_8","volume":"1285","author":"XY Li","year":"2021","unstructured":"Li XY, Zheng SX, Wu G (2021a) Nutrition and functions of amino acids in fish. Adv Exp Med Biol 1285:133\u2013168","journal-title":"Adv Exp Med Biol"},{"key":"13_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-030-54462-1_9","volume":"1285","author":"XY Li","year":"2021","unstructured":"Li XY, Han T, Zheng SX, Wu G (2021b) Nutrition and functions of amino acids in aquatic crustaceans. Adv Exp Med Biol 1285:169\u2013198","journal-title":"Adv Exp Med Biol"},{"key":"13_CR47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00726-020-02920-6","volume":"53","author":"XY Li","year":"2021","unstructured":"Li XY, Zheng SX, Ma XK, Cheng KM, Wu G (2021c) Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part I: effects of poultry by-product meal and soybean meal on growth, feed utilization, and health. Amino Acids 53:33\u201347","journal-title":"Amino Acids"},{"key":"13_CR48","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00726-020-02922-4","volume":"53","author":"XY Li","year":"2021","unstructured":"Li XY, Zheng SX, Cheng KM, Ma XK, Wu G (2021d) Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part II: effects of supplementation with methionine or taurine on growth, feed utilization, and health. Amino Acids 53:49\u201362","journal-title":"Amino Acids"},{"key":"13_CR49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-3-030-74180-8_11","volume":"1332","author":"P Li","year":"2021","unstructured":"Li P, He WL, Wu G (2021e) Composition of amino acids in foodstuffs for humans and animals. Adv Exp Med Biol 1332:189\u2013209","journal-title":"Adv Exp Med Biol"},{"key":"13_CR50","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/BF01611398","volume":"36","author":"KA Lien","year":"1997","unstructured":"Lien KA, Sauer WC, Fenton M (1997) Mucin output in ileal digesta of pigs fed a protein-free diet. Z. Ern\u00e4hrungswiss 36:182\u2013190","journal-title":"Z. Ern\u00e4hrungswiss"},{"key":"13_CR51","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/1097-4644(20010601)81:3<463::AID-JCB1060>3.0.CO;2-L","volume":"81","author":"C Lussier","year":"2001","unstructured":"Lussier C, Sodek J, Beaulieu JF (2001) Expression of SPARC\/osteonectin\/BM4O in the human gut: predominance in the stroma of the remodeling distal intestine. J Cell Biochem 81:463\u2013476","journal-title":"J Cell Biochem"},{"key":"13_CR52","first-page":"83","volume-title":"Handbook of Physiology: The Gastrointestinal System (Shultz SG","author":"JL Madara","year":"1991","unstructured":"Madara JL (1991) Functional morphology of epithelium of the small intestine. In: Physiological A (ed) Handbook of Physiology: The Gastrointestinal System (Shultz SG. Society, Bethesda, pp 83\u2013120"},{"key":"13_CR53","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrmicro2538","volume":"9","author":"MA McGuckin","year":"2011","unstructured":"McGuckin MA, Lind\u00e9n SK, Sutton P, Florin TH (2011) Mucin dynamics and enteric pathogens. Nat Rev Microbiol 9:265\u2013278","journal-title":"Nat Rev Microbiol"},{"key":"13_CR54","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cbpc.2005.04.009","volume":"141","author":"JA McLean","year":"2005","unstructured":"McLean JA, Karadas F, Surai PF, McDevitt RM, Speake BK (2005) Lipid-soluble and water-soluble antioxidant activities of the avian intestinal mucosa at different sites along the intestinal tract. Comp Biochem Physiol B 141:366\u2013372","journal-title":"Comp Biochem Physiol B"},{"key":"13_CR55","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev.mi.35.100181.002401","volume":"35","author":"PC McNabb","year":"1981","unstructured":"McNabb PC, Tomasi TB (1981) Host defense mechanisms at mucosal surfaces. Annu Rev Microbiol 35:477\u2013496","journal-title":"Annu Rev Microbiol"},{"key":"13_CR56","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1079\/NRR200365","volume":"16","author":"PJ Moughan","year":"2003","unstructured":"Moughan PJ (2003) Amino acid availability\u2014aspects of chemical analysis and bioassay methodology. Nutr Res Rev 16:127\u2013141","journal-title":"Nutr Res Rev"},{"key":"13_CR57","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fimmu.2012.00310","volume":"3","author":"LR Muniz","year":"2012","unstructured":"Muniz LR, Knosp C, Yeretssian G (2012) Intestinal antimicrobial peptides during homeostasis, infection, and disease. Front Immunol 3:310","journal-title":"Front Immunol"},{"key":"13_CR58","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-3-030-54462-1_10","volume":"1285","author":"AM Oberbauer","year":"2021","unstructured":"Oberbauer AM, Larsen JA (2021) Amino acids in dog nutrition and health. Adv Exp Med Biol 1285:199\u2013216","journal-title":"Adv Exp Med Biol"},{"key":"13_CR59","first-page":"G807","volume":"260","author":"K Opleta-Madsen","year":"1991","unstructured":"Opleta-Madsen K, Hardin J, Gall DG (1991) Epidermal growth factor upregulates intestinal electrolyte and nutrient transport. Am J Physiol 260:G807-814","journal-title":"Am J Physiol"},{"key":"13_CR60","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-3-030-74180-8_2","volume":"1332","author":"S Paudel","year":"2021","unstructured":"Paudel S, Wu G, Wang XQ (2021) Amino acids in cell signaling: regulation and function. Adv Exp Med Biol 1332:17\u201333","journal-title":"Adv Exp Med Biol"},{"key":"13_CR61","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1210\/endo.140.2.6495","volume":"140","author":"S Pu","year":"1999","unstructured":"Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP (1999) Interactions between neuropeptide Y and \u03b3-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 140:933\u2013940","journal-title":"Endocrinology"},{"key":"13_CR62","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-030-45328-2_8","volume":"1265","author":"WK Ren","year":"2020","unstructured":"Ren WK, Bin P, Yin YL, Wu G (2020) Impacts of amino acids on the intestinal defensive system. Adv Exp Med Biol 1265:133\u2013151","journal-title":"Adv Exp Med Biol"},{"key":"13_CR63","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00726-012-1420-x","volume":"44","author":"R Rezaei","year":"2013","unstructured":"Rezaei R, Knabe DA, Tekwe CD, Dahanayaka S, Ficken MD, Fielder SE, Eide SJ, Lovering SL, Wu G (2013) Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs. Amino Acids 44:911\u2013923","journal-title":"Amino Acids"},{"key":"13_CR64","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00726-008-0225-4","volume":"37","author":"JM Rhoads","year":"2009","unstructured":"Rhoads JM, Wu G (2009) Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 37:111\u2013122","journal-title":"Amino Acids"},{"key":"13_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-74180-8_1","volume":"1332","author":"N Sah","year":"2021","unstructured":"Sah N, Wu G, Bazer FW (2021) Regulation of gene expression by amino acids in animal cells. Adv Exp Med Biol 1332:1\u201315","journal-title":"Adv Exp Med Biol"},{"key":"13_CR66","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.2527\/jas.2010-3399","volume":"89","author":"JL Sartin","year":"2011","unstructured":"Sartin JL, Whitlock BK, Daniel JA (2011) Triennial Growth Symposium: neural regulation of feed intake: modification by hormones, fasting, and disease. J Anim Sci 89:1991\u20132003","journal-title":"J Anim Sci"},{"key":"13_CR67","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1093\/jn\/120.10.1179","volume":"120","author":"S Satchithanandam","year":"1990","unstructured":"Satchithanandam S, Vargofcak-Apker M, Valvert RJ, Leeds AR, Sassidy MM (1990) Alteration of gastrointestinal mucin by fiber feeding in rats. J Nutr 120:1179\u20131184","journal-title":"J Nutr"},{"key":"13_CR68","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-3-030-74180-8_4","volume":"1332","author":"JZ Shen","year":"2021","unstructured":"Shen JZ, Wu G, Guo SD (2021) Amino acids in autophagy: Regulation and function. Adv Exp Med Biol 1332:51\u201366","journal-title":"Adv Exp Med Biol"},{"key":"13_CR69","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1523\/JNEUROSCI.2064-11.2012","volume":"32","author":"BM Song","year":"2012","unstructured":"Song BM, Avery L (2012) Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans. J Neurosci 32:1920\u20131931","journal-title":"J Neurosci"},{"key":"13_CR70","doi-asserted-by":"crossref","unstructured":"Tang T, Zhong L, Yu D, Li P, Hu Y (2021) Evaluation of dried porcine solubles in diets of rice field eel (Monopterus albus). Aquaculture 531:735897","DOI":"10.1016\/j.aquaculture.2020.735897"},{"key":"13_CR71","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/2049-1891-4-35","volume":"4","author":"PA Thacker","year":"2013","unstructured":"Thacker PA (2013) Alternatives to antibiotics as growth promoters for use in swine production: a review. J Anim Sci Biotechnol 4:35","journal-title":"J Anim Sci Biotechnol"},{"key":"13_CR72","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9:799\u2013809","journal-title":"Nat Rev Immunol"},{"key":"13_CR73","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tics.2010.11.001","volume":"15","author":"ND Volkow","year":"2011","unstructured":"Volkow ND, Wang GJ, Baler RD (2011) Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci 15:37\u201346","journal-title":"Trends Cogn Sci"},{"key":"13_CR74","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3945\/jn.109.118497","volume":"140","author":"WW Wang","year":"2010","unstructured":"Wang WW, Zeng XF, Mao XB, Wu G, Qiao SY (2010) Optimal dietary true ileal digestible threonine for supporting mucosal barrier in the small intestine of weanling pigs. J Nutr 140:981\u2013986","journal-title":"J Nutr"},{"key":"13_CR75","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s00726-014-1758-3","volume":"46","author":"WW Wang","year":"2014","unstructured":"Wang WW, Dai ZL, Wu ZL, Lin G, Jia SC, Hu SD, Dahanayaka S, Wu G (2014) Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs. Amino Acids 46:2037\u20132045","journal-title":"Amino Acids"},{"key":"13_CR76","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/af\/vfab002","volume":"11","author":"AD Wilkinson","year":"2021","unstructured":"Wilkinson AD, Meeker DL (2021) How agricultural rendering supports sustainability and assists livestock\u2019s ability to contribute more than just food. Anim Front 11:24\u201334","journal-title":"Anim Front"},{"key":"13_CR77","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1093\/jn\/128.8.1249","volume":"128","author":"G Wu","year":"1998","unstructured":"Wu G (1998) Intestinal mucosal amino acid catabolism. J Nutr 128:1249\u20131252","journal-title":"J Nutr"},{"key":"13_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","volume":"37","author":"G Wu","year":"2009","unstructured":"Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37:1\u201317","journal-title":"Amino Acids"},{"key":"13_CR79","volume-title":"Principles of animal nutrition","author":"G Wu","year":"2018","unstructured":"Wu G (2018) Principles of animal nutrition. CRC Press, Boca Raton, Florida"},{"key":"13_CR80","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00726-020-02823-6","volume":"52","author":"G Wu","year":"2020","unstructured":"Wu G (2020a) Important roles of dietary taurine, creatine, carnosine, anserine and hydroxyproline in human nutrition and health. Amino Acids 52:329\u2013360","journal-title":"Amino Acids"},{"key":"13_CR81","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/978-3-030-45328-2_12","volume":"1265","author":"G Wu","year":"2020","unstructured":"Wu G (2020b) Metabolism and functions of amino acids in sense organs. Adv Exp Med Biol 1265:201\u2013217","journal-title":"Adv Exp Med Biol"},{"key":"13_CR82","doi-asserted-by":"publisher","DOI":"10.1201\/9781003092742","volume-title":"Amino acids: biochemistry and nutrition","author":"G Wu","year":"2021","unstructured":"Wu G (2021) Amino acids: biochemistry and nutrition, 2nd ed. CRC Press, Boca Raton, Florida"},{"key":"13_CR94","doi-asserted-by":"crossref","unstructured":"Wu G (2022) Nutrition and metabolism: Foundations for animal growth, development, reproduction, and health. Adv Exp Med\nBiol 1354:1\u201324","DOI":"10.1007\/978-3-030-85686-1_1"},{"key":"13_CR83","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/jn\/134.3.489","volume":"134","author":"G Wu","year":"2004","unstructured":"Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134:489\u2013492","journal-title":"J Nutr"},{"key":"13_CR84","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.1093\/jas\/sky377","volume":"96","author":"G Wu","year":"2018","unstructured":"Wu G, Bazer FW, Johnson GA, Hou YQ (2018) Arginine nutrition and metabolism in growing, gestating and lactating swine. J Anim Sci 96:5035\u20135051","journal-title":"J Anim Sci"},{"key":"13_CR85","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1089\/ars.2017.7338","volume":"30","author":"ZL Wu","year":"2019","unstructured":"Wu ZL, Hou YQ, Dai ZL, Hu CA, Wu G (2019) Metabolism, nutrition and redox signaling of hydroxyproline. Antioxid Redox Signal 30:674\u2013682","journal-title":"Antioxid Redox Signal"},{"key":"13_CR86","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-3-030-74180-8_10","volume":"1332","author":"G Wu","year":"2021","unstructured":"Wu G, Meininger CJ, McNeal CJ, Bazer FW, Rhoads JM (2021) Role of L-arginine in nitric oxide synthesis and health in humans. Adv Exp Med Biol 1332:167\u2013188","journal-title":"Adv Exp Med Biol"},{"key":"13_CR95","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1210\/er.2018-00283","volume":"40","author":"JM Yabut","year":"2019","unstructured":"Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR (2019) Emerging roles for serotonin in regulating metabolism: New implications for an ancient molecule. Endocrine Rev 40:1092\u20131107","journal-title":"Endocrine Rev"},{"key":"13_CR87","first-page":"R235","volume":"292","author":"YK Yang","year":"2007","unstructured":"Yang YK, Chen M, Georgeson KE, Harmon CM (2007) Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction. Am J Physiol 292:R235\u2013R241","journal-title":"Am J Physiol"},{"key":"13_CR88","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-030-74180-8_3","volume":"1332","author":"Y Yang","year":"2021","unstructured":"Yang Y, He Y, Jin Y, Wu G, Wu ZL (2021) Amino acids in endoplasmic reticulum stress and redox signaling. Adv Exp Med Biol 1332:35\u201349","journal-title":"Adv Exp Med Biol"},{"key":"13_CR89","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-030-54462-1_6","volume":"1285","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Hou YQ, Bazer FW, He WL, Posey EA, Wu G (2021a) Amino acids in swine nutrition and production. Adv Exp Med Biol 1285:81\u2013107","journal-title":"Adv Exp Med Biol"},{"key":"13_CR96","doi-asserted-by":"publisher","unstructured":"Zhang Y, Mu T, Jia H et al. (2021b) Protective effects of glycine against lipopolysaccharide-induced intestinal apoptosis and inflammation. Amino Acids. https:\/\/doi.org\/10.1007\/s00726-021-03011-w","DOI":"10.1007\/s00726-021-03011-w"}],"container-title":["Advances in Experimental Medicine and Biology","Recent Advances in Animal Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-85686-1_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T03:30:38Z","timestamp":1666495838000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-85686-1_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"ISBN":["9783030856854","9783030856861"],"references-count":98,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-85686-1_13","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"23 November 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}