{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:34:29Z","timestamp":1743136469672,"version":"3.40.3"},"publisher-location":"Cham","reference-count":15,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030883577"},{"type":"electronic","value":"9783030883584"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-88358-4_9","type":"book-chapter","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T04:30:15Z","timestamp":1634013015000},"page":"104-113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterization and Treatment of the Temporal Dimension of Genomic Variations: A Conceptual Model-Based Approach"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-4363","authenticated-orcid":false,"given":"Alberto","family":"Garc\u00eda Sim\u00f3n","sequence":"first","affiliation":[]},{"given":"Mireia","family":"Costa S\u00e1nchez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-8471","authenticated-orcid":false,"given":"Oscar","family":"Pastor","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","unstructured":"Campuzano, O., et al.: Reanalysis and reclassification of rare genetic variants associated with inherited arrhythmogenic syndromes. EBioMedicine 54, 102732 (2020). https:\/\/doi.org\/10.1016\/j.ebiom.2020.102732","DOI":"10.1016\/j.ebiom.2020.102732"},{"key":"9_CR2","doi-asserted-by":"publisher","unstructured":"Costa, M., Le\u00f3n, A., Pastor, O.: The importance of the temporal dimension in identifying relevant genomic variants: a case study. In: Grossmann, G., Ram, S. (eds.) Advances in Conceptual Modeling. ER 2020. Lecture Notes in Computer Science, vol. 12584, pp. 51\u201360. Springer, Cham (2020). https:\/\/doi.org\/10.1007\/978-3-030-65847-2_5","DOI":"10.1007\/978-3-030-65847-2_5"},{"issue":"3","key":"9_CR3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1093\/bib\/bbv060","volume":"17","author":"DJ Duffy","year":"2016","unstructured":"Duffy, D.J.: Problems, challenges and promises: perspectives on precision medicine. Brief. Bioinform. 17(3), 494\u2013504 (2016). https:\/\/doi.org\/10.1093\/bib\/bbv060","journal-title":"Brief. Bioinform."},{"key":"9_CR4","series-title":"Lecture Notes in Business Information Processing","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/978-3-030-63396-7_2","volume-title":"Information Systems","author":"J Galv\u00e3o","year":"2020","unstructured":"Galv\u00e3o, J., Leon, A., Costa, C., Santos, M.Y., L\u00f3pez, \u00d3.P.: Automating data integration in adaptive and data-intensive information systems. In: Themistocleous, M., Papadaki, M., Kamal, M.M. (eds.) EMCIS 2020. LNBIP, vol. 402, pp. 20\u201334. Springer, Cham (2020). https:\/\/doi.org\/10.1007\/978-3-030-63396-7_2"},{"key":"9_CR5","doi-asserted-by":"publisher","unstructured":"Garc\u00eda S., A., Casamayor, J.C.: Towards the generation of a species-independent conceptual schema of the genome. In: Grossmann, G., Ram, S. (eds.) Advances in Conceptual Modeling. ER 2020. Lecture Notes in Computer Science, vol. 12584, pp. 61\u201370. Springer, Cham (2020). https:\/\/doi.org\/10.1007\/978-3-030-65847-2_6","DOI":"10.1007\/978-3-030-65847-2_6"},{"key":"9_CR6","series-title":"Lecture Notes in Business Information Processing","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-3-030-79108-7_6","volume-title":"Intelligent Information Systems","author":"A Garc\u00eda S.","year":"2021","unstructured":"Garc\u00eda S., A., Casamayor, J.C., Pastor, O.: ISGE: a conceptual model-based method to correctly manage genome data. In: Nurcan, S., Korthaus, A. (eds.) CAiSE 2021. LNBIP, vol. 424, pp. 47\u201354. Springer, Cham (2021). https:\/\/doi.org\/10.1007\/978-3-030-79108-7_6"},{"key":"9_CR7","series-title":"Lecture Notes in Business Information Processing","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-030-79108-7_1","volume-title":"Intelligent Information Systems","author":"A Le\u00f3n","year":"2021","unstructured":"Le\u00f3n, A., Garc\u00eda S., A., Costa, M., Va\u00f1\u00f3 Ribelles, A., Pastor, O.: Evolution of an adaptive information system for precision medicine. In: Nurcan, S., Korthaus, A. (eds.) CAiSE 2021. LNBIP, vol. 424, pp. 3\u201310. Springer, Cham (2021). https:\/\/doi.org\/10.1007\/978-3-030-79108-7_1"},{"key":"9_CR8","doi-asserted-by":"publisher","unstructured":"Mersch, J.: Prevalence of variant reclassification following hereditary cancer genetic testing. JAMA 320(12), 1266\u20131274 (2018). https:\/\/doi.org\/10.1001\/jama.2018.13152","DOI":"10.1001\/jama.2018.13152"},{"key":"9_CR9","doi-asserted-by":"publisher","unstructured":"Miller, D.T., et al.: ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG). Genetics in Medicine, pp. 1\u201310. Nature Publishing Group (May 2021). https:\/\/doi.org\/10.1038\/s41436-021-01172-3","DOI":"10.1038\/s41436-021-01172-3"},{"key":"9_CR10","doi-asserted-by":"publisher","unstructured":"Palacio, A.L., L\u00f3pez, O.P.: Smart data for genomic information systems: the SILE method. Complex Syst. Inform. Model. Q. (17), 1\u201323 (2018). https:\/\/doi.org\/10.7250\/csimq.2018-17.01","DOI":"10.7250\/csimq.2018-17.01"},{"key":"9_CR11","doi-asserted-by":"publisher","unstructured":"Plon, S.E., Rehm, H.L.: The ancestral pace of variant reclassification. JNCI J. Natl. Cancer Inst. 110(10), 1133\u20131134 (2018). https:\/\/doi.org\/10.1093\/jnci\/djy075","DOI":"10.1093\/jnci\/djy075"},{"key":"9_CR12","doi-asserted-by":"publisher","unstructured":"Slavin, T.P., et al.: The effects of genomic germline variant reclassification on clinical cancer care. Oncotarget 10(4), 417\u2013423 (2019). https:\/\/doi.org\/10.18632\/oncotarget.26501","DOI":"10.18632\/oncotarget.26501"},{"key":"9_CR13","doi-asserted-by":"publisher","unstructured":"Stephens, Z.D.: Big data: astronomical or genomical? PLOS Biol. 13(7), e1002195. Public Library of Science (2015). https:\/\/doi.org\/10.1371\/journal.pbio.1002195","DOI":"10.1371\/journal.pbio.1002195"},{"key":"9_CR14","doi-asserted-by":"publisher","unstructured":"Vihinen, M.: Problems in variation interpretation guidelines and in their implementation in computational tools. Mole. Genet. Genomic Med. 8(9), e1206 (2020). https:\/\/doi.org\/10.1002\/mgg3.1206","DOI":"10.1002\/mgg3.1206"},{"key":"9_CR15","doi-asserted-by":"publisher","unstructured":"Wong, E.K., et al.: Perceptions of genetic variant reclassification in patients with inherited cardiac disease. Eur. J. Hum. Genet. 27(7), 1134\u20131142. Nature Publishing Group (2019). https:\/\/doi.org\/10.1038\/s41431-019-0377-6","DOI":"10.1038\/s41431-019-0377-6"}],"container-title":["Lecture Notes in Computer Science","Advances in Conceptual Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-88358-4_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T04:40:29Z","timestamp":1634013629000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-88358-4_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030883577","9783030883584"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-88358-4_9","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"11 October 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ER","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Conceptual Modeling","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2021","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"18 October 2021","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"21 October 2021","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"40","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"er2021","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/www.er2021.org\/index.html","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"EasyChair","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"85","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"14","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"18","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"16% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"3.9","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"2.4","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}