{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:53:03Z","timestamp":1783939983459,"version":"3.55.0"},"publisher-location":"Cham","reference-count":62,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030893392","type":"print"},{"value":"9783030893408","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-030-89340-8_1","type":"book-chapter","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T17:03:39Z","timestamp":1654016619000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative Stress and Toxicity in Reproductive Biology and Medicine: Historical Perspectives and Future Horizons in Male Fertility"],"prefix":"10.1007","author":[{"given":"Ralf","family":"Henkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"1_CR1","first-page":"307","volume":"21","author":"S Abbasihormozi","year":"2019","unstructured":"Abbasihormozi S, Babapour V, Kouhkan A, Naslji AN, Afraz K, Zolfaghary Z, Shahverdi A. Stress hormone and oxidative stress biomarkers link obesity and diabetes with reduced fertility potential. Cell J. 2019;21:307\u201313.","journal-title":"Cell J"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1464-410X.2005.05328.x","volume":"95","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503\u20137.","journal-title":"BJU Int"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0022-5347(17)32829-X","volume":"152","author":"A Agarwal","year":"1994","unstructured":"Agarwal A, Ikemoto I, Loughlin KR. Relationship of sperm parameters with levels of reactive oxygen species in semen specimens. J Urol. 1994;152:107\u201310.","journal-title":"J Urol"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1477-7827-3-28","volume":"14","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005;14:28.","journal-title":"Reprod Biol Endocrinol"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1477-7827-10-49","volume":"10","author":"A Agarwal","year":"2012","unstructured":"Agarwal A, Aponte-Mellado A, Premkuma BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49.","journal-title":"Reprod Biol Endocrinol"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5534\/wjmh.200196","volume":"39","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Leisegang K, Majzoub A, Henkel R, Finelli R, Panner Selvam MK, Tadros N, Parekh N, Ko EY, Cho CL, Arafa M, Alves MG, Oliveira PF, Alvarez JG, Shah R. Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence. World J Mens Health. 2021a;39:233\u201390.","journal-title":"World J Mens Health"},{"key":"1_CR7","volume":"39","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Finelli R, Panner Selvam MK, et al. A global survey of reproductive specialists to determine the clinical utility of oxidative stress testing and antioxidant use in male infertility. World J Mens Health. 2021b;39:e17.","journal-title":"World J Mens Health"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-81-322-3604-7_12","volume-title":"Male Infertility","author":"G Ahmad","year":"2017","unstructured":"Ahmad G, Agarwal A. Ionizing radiation and male fertility. In: Gunasekaran K, Pandiyan N, editors. Male Infertility. Springer; 2017. p. 185\u201396."},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1530\/jrf.0.0810459","volume":"81","author":"RJ Aitken","year":"1987","unstructured":"Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fert. 1987;81:459\u201369.","journal-title":"J Reprod Fert"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0002-9378(11)80017-7","volume":"164","author":"RJ Aitken","year":"1991","unstructured":"Aitken RJ, Irvine DS, Wu FC. Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol. 1991;164:542\u201351.","journal-title":"Am J Obstet Gynecol"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"633","DOI":"10.4103\/1008-682X.153850","volume":"17","author":"RJ Aitken","year":"2015","unstructured":"Aitken RJ, Baker MA, Nixon B. Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress? Asian J Androl. 2015;17:633\u20139.","journal-title":"Asian J Androl"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.bi.58.070189.000455","volume":"58","author":"E Cadenas","year":"1989","unstructured":"Cadenas E. Biochemistry of oxygen toxicity. Annu Rev Biochem. 1989;58:79\u2013110.","journal-title":"Annu Rev Biochem"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0306-4522(99)00138-4","volume":"93","author":"V Castagne","year":"1999","unstructured":"Castagne V, Lefevre K, Natero R, Clarke PG, Bedker DA. An optimal redox status for the survival of axotomized ganglion cells in the developing retina. Neuroscience. 1999;93:313\u201320.","journal-title":"Neuroscience"},{"key":"1_CR14","first-page":"1","volume-title":"Healing Herbs","author":"M Castleman","year":"1995","unstructured":"Castleman M. Healing Herbs. New York: Bantam Books; 1995. p. 1\u20135."},{"key":"1_CR15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/j.1939-4640.1994.tb00507.x","volume":"15","author":"GM Centola","year":"1994","unstructured":"Centola GM, Keller JW, Henzler M, Rubin P. Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl. 1994;15:608\u201313.","journal-title":"J Androl"},{"key":"1_CR16","first-page":"9","volume-title":"Herbal Medicine in Andrology \u2013 An Evidence-Based Update","author":"R Dada","year":"2020","unstructured":"Dada R, Sabharwal P, Sharma A, Henkel R. Use of herbal medicine as primary or supplementary treatments. In: Henkel R, Agarwal A, editors. Herbal Medicine in Andrology \u2013 An Evidence-Based Update. London: Elsevier Academic Press; 2020. p. 9\u201315."},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0891-5849(93)90006-G","volume":"14","author":"E de Lamirande","year":"1993","unstructured":"de Lamirande E, Gagnon C. Human sperm hyperactivation and capacitation as parts of an oxidative process. Free Radical Biol Med. 1993;14:157\u201366.","journal-title":"Free Radical Biol Med"},{"issue":"Suppl 1","key":"1_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/humrep\/10.suppl_1.15","volume":"10","author":"E de Lamirande","year":"1995","unstructured":"de Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod. 1995;10(Suppl 1):15\u201321.","journal-title":"Hum Reprod"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1530\/ror.0.0020048","volume":"2","author":"E de Lamirande","year":"1997","unstructured":"de Lamirande E, Jiang H, Zini A, Kodama H, Gagnon C. Reactive oxygen species and sperm physiology. Rev Reprod. 1997;2:48\u201354.","journal-title":"Rev Reprod"},{"key":"1_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2164\/jandrol.106.001487","volume":"28","author":"G Delbes","year":"2007","unstructured":"Delbes G, Hales BF, Robaire B. Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity. J Androl. 2007;28:241\u20139.","journal-title":"J Androl"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12958-018-0449-4","volume":"17","author":"A Di Nisio","year":"2019","unstructured":"Di Nisio A, Foresta C. Water and soil pollution as determinant of water and food quality\/contamination and its impact on male fertility. Reprod Biol Endocrinol. 2019;17:4.","journal-title":"Reprod Biol Endocrinol"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aju.2017.12.004","volume":"16","author":"D Durairajanayagam","year":"2018","unstructured":"Durairajanayagam D. Lifestyle causes of male infertility. Arab J Urol. 2018;16:10\u201320.","journal-title":"Arab J Urol"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/sj.cdd.4401754","volume":"12","author":"G Filomeni","year":"2005","unstructured":"Filomeni G, Rotilio G, Ciriolo MR. Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways. Cell Death Differ. 2005;12:1555\u201363.","journal-title":"Cell Death Differ"},{"key":"1_CR24","first-page":"573","volume":"13","author":"J Gandhi","year":"2017","unstructured":"Gandhi J, Dagur G, Warren K, Smith NL, Sheynkin YR, Zumbo A, Khan SA. The role of diabetes mellitus in sexual and reproductive health: An overview of pathogenesis, evaluation, and management. Curr Diabetes Rev. 2017;13:573\u201381.","journal-title":"Curr Diabetes Rev"},{"key":"1_CR25","first-page":"15","volume":"57","author":"K Gill","year":"2019","unstructured":"Gill K, Jakubik J, Kups M, Rosiak-Gill A, Kurzawa R, Kurpisz M, Fraczek M, Piasecka M. The impact of sedentary work on sperm nuclear DNA integrity. Folia Histochem Cytobiol. 2019;57:15\u201322.","journal-title":"Folia Histochem Cytobiol"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1586\/17474108.2013.849418","volume":"8","author":"S Gupta","year":"2013","unstructured":"Gupta S, Fedor J, Biedenharn K, Agarwal A. Lifestyle factors and oxidative stress in female infertility: is there an evidence base to support the linkage? Expert Rev Obstet Gynecol. 2013;8:607\u201324.","journal-title":"Expert Rev Obstet Gynecol"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2005.07.008","volume":"27","author":"A Gurib-Fakim","year":"2006","unstructured":"Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006;27:1\u201393.","journal-title":"Mol Aspects Med"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbrc.2018.05.045","volume":"502","author":"JMC Gutteridge","year":"2018","unstructured":"Gutteridge JMC, Halliwell B. Mini-review: oxidative stress, redox stress or redox success? Biochem Biophys Res Commun. 2018;502:183\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"1_CR29","volume-title":"Free Radicals in Biology and Medicine","author":"B Halliwell","year":"1989","unstructured":"Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 2nd ed. Oxford: Clarendon Press; 1989.","edition":"2"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/bdrc.20085","volume":"78","author":"JM Hansen","year":"2006","unstructured":"Hansen JM. Oxidative stress as a mechanism of teratogenesis. Birth Defects Res C Embryo Today. 2006;78:293\u2013307.","journal-title":"Birth Defects Res C Embryo Today"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1530\/rep.0.1230479","volume":"123","author":"AJ Harvey","year":"2002","unstructured":"Harvey AJ, Kind KL, Thompson JG. REDOX regulation of early embryo development. Reproduction. 2002;123:479\u201386.","journal-title":"Reproduction"},{"key":"1_CR32","first-page":"191","volume-title":"Handbook of Bioenvironmental Toxicology: Men\u2019s Reproductive & Sexual Health","author":"R Henkel","year":"2018","unstructured":"Henkel R. Environmental Contamination and Testicular Function. In: Sikka SC, Hellstrom WJG, editors. Handbook of Bioenvironmental Toxicology: Men\u2019s Reproductive & Sexual Health. Elsevier; 2018. p. 191\u2013208."},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/978-3-030-32300-4_32","volume-title":"Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants","author":"R Henkel","year":"2020","unstructured":"Henkel R. Infection in Infertility. In: Parekattil SJ, Esteves SC, Agarwal A, editors. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. 2nd ed. Cham: Springer; 2020. p. 409\u201324.","edition":"2"},{"key":"1_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/and.13162","volume":"51","author":"R Henkel","year":"2019","unstructured":"Henkel R, Sandhu IS, Agarwal A. The excessive use of antioxidant therapy: a possible cause of male infertility? Andrologia. 2019;51:e13162.","journal-title":"Andrologia"},{"key":"1_CR35","doi-asserted-by":"publisher","unstructured":"Henkel R, Offor U, Fisher D. The role of infections and leukocytes in male infertility. Andrologia. 2020 Jul 21;e13743. doi: https:\/\/doi.org\/10.1111\/and.13743. Online ahead of print.","DOI":"10.1111\/and.13743"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/humupd\/7.4.363","volume":"7","author":"SJ Howell","year":"2001","unstructured":"Howell SJ, Shalet SM. Testicular function following chemotherapy. Hum Reprod Update. 2001;7:363\u20139.","journal-title":"Hum Reprod Update"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nrurol.2017.98","volume":"14","author":"CFS Jensen","year":"2017","unstructured":"Jensen CFS, \u00d8stergren P, Dupree JM, Ohl DA, S\u00f8nksen J, Fode M. Varicocele and male infertility. Nat Rev Urol. 2017;14:523\u201333.","journal-title":"Nat Rev Urol"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1439-0272.2007.00794.x","volume":"39","author":"A Jung","year":"2007","unstructured":"Jung A, Schuppe HC. Influence of genital heat stress on semen quality in humans. Andrologia. 2007;39:203\u201315.","journal-title":"Andrologia"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.urology.2019.11.007","volume":"136","author":"M Kuchakulla","year":"2020","unstructured":"Kuchakulla M, Soni Y, Patel P, Parekh N, Ramasamy R. A systematic review and evidence-based analysis of ingredients in popular male fertility supplements. Urology. 2020;136:133\u201341.","journal-title":"Urology"},{"key":"1_CR40","first-page":"19","volume":"11","author":"M Lao","year":"2015","unstructured":"Lao M, Honig SC. Male infertility and subsequent risk of cancer development. J Men\u2019s Health. 2015;11:19\u201328.","journal-title":"J Men\u2019s Health"},{"key":"1_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/humupd\/1.1.63","volume":"1","author":"HJ Leese","year":"1995","unstructured":"Leese HJ. Metabolic control during preimplantation mammalian development. Hum Reprod Update. 1995;1:63\u201372.","journal-title":"Hum Reprod Update"},{"key":"1_CR42","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13178","volume":"82","author":"K Leisegang","year":"2019","unstructured":"Leisegang K, Henkel R, Agarwal A. Obesity and metabolic syndrome associated systemic inflammation and the impact on the male reproductive system. Am J Reprod Immunol. 2019;82:e13178.","journal-title":"Am J Reprod Immunol"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1079\/BJN2001435","volume":"87","author":"B Lipinski","year":"2002","unstructured":"Lipinski B. Evidence in support of a concept of reductive stress. Br J Nutr. 2002;87:93\u20134.","journal-title":"Br J Nutr"},{"key":"1_CR44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/mrd.23447","volume":"88","author":"S Luti","year":"2021","unstructured":"Luti S, Fiaschi T, Magherini F, Modesti PA, Piomboni P, Semplici B, Morgante G, Amoresano A, Illiano A, Pinto G, Modesti A, Gamberi T. Follicular microenvironment: Oxidative stress and adiponectin correlated with steroids hormones in women undergoing in vitro fertilization. Mol Reprod Dev. 2021;88:175\u201384.","journal-title":"Mol Reprod Dev"},{"key":"1_CR45","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1152\/ajplegacy.1943.138.3.512","volume":"138","author":"J MacLeod","year":"1943","unstructured":"MacLeod J. The role of oxygen in the metabolism and motility of human spermatozoa. Am J Physiol. 1943;138:512\u20138.","journal-title":"Am J Physiol"},{"key":"1_CR46","doi-asserted-by":"publisher","first-page":"114","DOI":"10.2174\/1874255601103010114","volume":"3","author":"PP Mathur","year":"2011","unstructured":"Mathur PP, Huang L, Kashou A, Vaithinathan S, Agarwal A. Environmental toxicants and testicular apoptosis. Open Reprod Sci J. 2011;3:114\u201324.","journal-title":"Open Reprod Sci J"},{"issue":"1A","key":"1_CR47","first-page":"S3","volume":"5","author":"J Mendiola","year":"2009","unstructured":"Mendiola J, Torres-Cantero AM, Agarwal A. Lifestyle factors and male infertility: an evidence-based review. Arch Med Sci. 2009;5(1A):S3\u2013S12.","journal-title":"Arch Med Sci"},{"key":"1_CR48","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1093\/humrep\/dey259","volume":"33","author":"L Minguez-Alarcon","year":"2018","unstructured":"Minguez-Alarcon L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE. Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod. 2018;33:1749\u201356.","journal-title":"Hum Reprod"},{"key":"1_CR49","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2051-4190-24-4","volume":"24","author":"C O\u2019Flaherty","year":"2014","unstructured":"O\u2019Flaherty C. Peroxiredoxins: hidden players in the antioxidant defence of human spermatozoa. Basic Clin Androl. 2014;24:4.","journal-title":"Basic Clin Androl"},{"key":"1_CR50","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0093-691X(99)00129-6","volume":"52","author":"CM O\u2019Flaherty","year":"1999","unstructured":"O\u2019Flaherty CM, Beorlegui NB, Beconi MT. Reactive oxygen species requirements for bovine sperm capacitation and acrosome reaction. Theriogenology. 1999;52:289\u2013301.","journal-title":"Theriogenology"},{"key":"1_CR51","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0090-4295(96)00313-5","volume":"48","author":"RK Sharma","year":"1996","unstructured":"Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology. 1996;48:835\u201350.","journal-title":"Urology"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-642760-8.50005-3","volume-title":"Oxidative Stress","author":"H Sies","year":"1985","unstructured":"Sies H. Oxidative Stress. London: Academic Press; 1985. p. 1\u2013507."},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","volume":"289","author":"H Sies","year":"2014","unstructured":"Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem. 2014;289:8735\u201341.","journal-title":"J Biol Chem"},{"key":"1_CR54","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3390\/jcm9051400","volume":"9","author":"K Skoracka","year":"2020","unstructured":"Skoracka K, Eder P, Lykowska-Szuber L, Dobrowolska A, Krela-Kazmierczak I. Diet and nutritional factors in male (in)fertility-underestimated factors. J Clin Med. 2020;9:1400.","journal-title":"J Clin Med"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1365-2605.2005.00628.x","volume":"29","author":"GS Song","year":"2006","unstructured":"Song GS, Seo JT. Changes in the scrotal temperature of subjects in a sedentary posture over a heated floor. Int J Androl. 2006;29:446\u201357.","journal-title":"Int J Androl"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"6398520","DOI":"10.1155\/2020\/6398520","volume":"2020","author":"K Tobo\u0142a-Wr\u00f3bel","year":"2020","unstructured":"Tobo\u0142a-Wr\u00f3bel K, Pietryga M, Dydowicz P, Napiera\u0142a M, Br\u0105zert J, Florek E. Association of oxidative stress on pregnancy. Oxid Med Cell Longev. 2020;2020:6398520.","journal-title":"Oxid Med Cell Longev"},{"key":"1_CR57","doi-asserted-by":"publisher","first-page":"7230","DOI":"10.3390\/ijms16047230","volume":"16","author":"E Tvrda","year":"2015","unstructured":"Tvrda E, Agarwal A, Alkuhaimi N. Male reproductive cancers and infertility: a mutual relationship. Int J Mol Sci. 2015;16:7230\u201360.","journal-title":"Int J Mol Sci"},{"key":"1_CR58","first-page":"12","volume":"4","author":"C Ufer","year":"2011","unstructured":"Ufer C, Wang CC. The roles of glutathione peroxidases during embryo development. Front Mol Neurosci. 2011;4:12.","journal-title":"Front Mol Neurosci"},{"key":"1_CR59","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1089\/ars.2009.3044","volume":"13","author":"C Ufer","year":"2010","unstructured":"Ufer C, Wang CC, Borchert A, Heydeck D, Kuhn H. Redox control in mammalian embryo development. Antioxid Redox Signal. 2010;13:833\u201375.","journal-title":"Antioxid Redox Signal"},{"key":"1_CR60","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.rbmo.2010.11.009","volume":"22","author":"AC Varghese","year":"2011","unstructured":"Varghese AC, Ly KD, Corbin C, Mendiola J, Agarwal A. Oocyte developmental competence and embryo development: impact of lifestyle and environmental risk factors. Reprod Biomed Online. 2011;22:410\u201320.","journal-title":"Reprod Biomed Online"},{"key":"1_CR61","volume-title":"Reactive Oxygen Species and Disease","author":"CC Wang","year":"2007","unstructured":"Wang CC, Rogers MS. Oxidative stress and fetal hypoxia. In: Laszlo G, editor. Reactive Oxygen Species and Disease. 282: Research Signpost, 257; 2007."},{"key":"1_CR62","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.rbmo.2014.02.004","volume":"28","author":"C Wright","year":"2014","unstructured":"Wright C, Milne S, Leeson H. Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reprod Biomed Online. 2014;28:684\u2013703.","journal-title":"Reprod Biomed Online"}],"container-title":["Advances in Experimental Medicine and Biology","Oxidative Stress and Toxicity in Reproductive Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-89340-8_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T13:07:43Z","timestamp":1700658463000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-89340-8_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783030893392","9783030893408"],"references-count":62,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-89340-8_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"1 June 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}