{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:43:21Z","timestamp":1794357801618,"version":"4.9.0"},"publisher-location":"Cham","reference-count":14,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031058424","type":"print"},{"value":"9783031058431","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-05843-1_30","type":"book-chapter","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:29:01Z","timestamp":1672532941000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Epithelial 5-HT4 Receptors as a Target for Treating Constipation and Intestinal Inflammation"],"prefix":"10.1007","author":[{"given":"Gary M.","family":"Mawe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Hurd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"30_CR1","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1111\/j.1572-0241.2008.01808.x","volume":"103","author":"WD Chey","year":"2008","unstructured":"Chey WD, Pare P, Viegas A, Ligozio G, Shetzline MA (2008) Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial. Am J Gastroenterol 103:1217\u20131225","journal-title":"Am J Gastroenterol"},{"key":"30_CR2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1365-2982.2005.00723.x","volume":"18","author":"B Greenwood-Van Meerveld","year":"2006","unstructured":"Greenwood-Van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD (2006) Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil 18:76\u201386","journal-title":"Neurogastroenterol Motil"},{"key":"30_CR3","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s004150050508","volume":"246","author":"A Hennessey","year":"1999","unstructured":"Hennessey A, Robertson NP, Swingler R, Compston DA (1999) Urinary, faecal and sexual dysfunction in patients with multiple sclerosis. J Neurol 246:1027\u20131032","journal-title":"J Neurol"},{"key":"30_CR4","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1053\/j.gastro.2011.12.041","volume":"142","author":"JM Hoffman","year":"2012","unstructured":"Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ (2012) Activation of colonic mucosal 5-HT4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology 142:844\u2013854. e844","journal-title":"Gastroenterology"},{"key":"30_CR5","first-page":"93","volume":"288","author":"J-G Jin","year":"1999","unstructured":"Jin J-G, Foxx-Orenstein AE, Grider J (1999) Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 288:93\u201397","journal-title":"J Pharmacol Exp Ther"},{"key":"30_CR6","first-page":"A754","volume":"112","author":"JG Jin","year":"1997","unstructured":"Jin JG, Foxx-Orenstein AE, Grider JR (1997) Stimulation of colonic propulsion by 5-HT4 receptor agonists: synergism by delta opioid receptor antagonists. Gastroenterology 112:A754","journal-title":"Gastroenterology"},{"key":"30_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","volume":"63","author":"ME Johansson","year":"2014","unstructured":"Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63:281\u2013291","journal-title":"Gut"},{"key":"30_CR8","doi-asserted-by":"publisher","first-page":"e14026","DOI":"10.1111\/nmo.14026","volume":"33","author":"JR Konen","year":"2021","unstructured":"Konen JR, Haag MM, Guseva D, Hurd M, Linton AA, Lavoie B, Kerrigan CB, Joyce E, Bischoff SC, Swann S, Griffin L, Matsukawa J, Falk MD, Gibson TS, Hennig GW, Wykosky J, Mawe GM (2021) Prokinetic actions of luminally acting 5-HT4 receptor agonists. Neurogastroenterol Motil 33:e14026","journal-title":"Neurogastroenterol Motil"},{"key":"30_CR9","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","volume":"10","author":"GM Mawe","year":"2013","unstructured":"Mawe GM, Hoffman JM (2013) Serotonin signalling in the gut\u2014functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol 10:473","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"30_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exger.2014.02.007","volume":"53","author":"BA Patel","year":"2014","unstructured":"Patel BA, Patel N, Fidalgo S, Wang C, Ranson RN, Saffrey MJ, Yeoman MS (2014) Impaired colonic motility and reduction in tachykinin signalling in the aged mouse. Exp Gerontol 53:24\u201330","journal-title":"Exp Gerontol"},{"key":"30_CR11","doi-asserted-by":"publisher","first-page":"e13349","DOI":"10.1111\/nmo.13349","volume":"30","author":"E Spear","year":"2018","unstructured":"Spear E, Holt E, Joyce E, Haag M, Mawe S, Hennig G, Lavoie B, Applebee A, Teuscher C, Mawe G (2018) Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Neurogastroenterol Motil 30:e13349","journal-title":"Neurogastroenterol Motil"},{"key":"30_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1053\/j.gastro.2016.07.032","volume":"151","author":"SN Spohn","year":"2016","unstructured":"Spohn SN, Bianco F, Scott RB, Keenan CM, Linton AA, O\u2019Neill CH, Bonora E, Dicay M, Lavoie B, Wilcox RL, MacNaughton WK, De Giorgio R, Sharkey KA, Mawe GM (2016) Protective actions of epithelial 5-hydroxytryptamine 4 receptors in normal and inflamed colon. Gastroenterology 151:933\u2013944 e933","journal-title":"Gastroenterology"},{"key":"30_CR13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","volume":"131","author":"M Van der Sluis","year":"2006","unstructured":"Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Buller HA, Dekker J, Van Seuningen I, Renes IB, Einerhand AW (2006) Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131:117\u2013129","journal-title":"Gastroenterology"},{"key":"30_CR14","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3389\/fnins.2019.00955","volume":"13","author":"CL West","year":"2019","unstructured":"West CL, Amin JY, Farhin S, Stanisz AM, Mao YK, Kunze WA (2019) Colonic motility and Jejunal vagal afferent firing rates are decreased in aged adult male mice and can be restored by an aminosterol. Front Neurosci 13:955","journal-title":"Front Neurosci"}],"container-title":["Advances in Experimental Medicine and Biology","The Enteric Nervous System II"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-05843-1_30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T01:09:16Z","timestamp":1672535356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-05843-1_30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031058424","9783031058431"],"references-count":14,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-05843-1_30","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-3-031-05843-1","asserted-by":"object"}]},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"1 January 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}