{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:40Z","timestamp":1791877420828,"version":"4.3.4"},"publisher-location":"Cham","reference-count":84,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031071669","type":"print"},{"value":"9783031071676","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-07167-6_5","type":"book-chapter","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T15:23:39Z","timestamp":1662477819000},"page":"111-130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Homeostatic Plasticity of the Mammalian Neuromuscular Junction"],"prefix":"10.1007","author":[{"given":"Kathrin L.","family":"Engisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"issue":"2","key":"5_CR1","first-page":"373","volume":"175","author":"JA Barstad","year":"1968","unstructured":"Barstad JA, Lilleheil G (1968) Transversaly cut diaphragm preparation from rat. An adjuvant tool in the study of the physiology and pbarmacology of the myoneural junction. Arch Int Pharmacodyn Ther 175(2):373\u2013390","journal-title":"Arch Int Pharmacodyn Ther"},{"issue":"47","key":"5_CR2","doi-asserted-by":"publisher","first-page":"12851","DOI":"10.1523\/JNEUROSCI.1997-07.2007","volume":"27","author":"EK Bichler","year":"2007","unstructured":"Bichler EK, Nakanishi ST, Wang QB, Pinter MJ, Rich MM, Cope TC (2007) Enhanced transmission at a spinal synapse triggered in vivo by an injury signal independent of altered synaptic activity. J Neurosci 27(47):12851\u201312859","journal-title":"J Neurosci"},{"issue":"3","key":"5_CR3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1476-5381.1972.tb08147.x","volume":"46","author":"LC Blaber","year":"1972","unstructured":"Blaber LC (1972) The mechanism of the facilitatory action of edrophonium in cat skeletal muscle. Br J Pharmacol 46(3):498\u2013507","journal-title":"Br J Pharmacol"},{"issue":"1","key":"5_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1113\/jphysiol.1956.sp005503","volume":"132","author":"IA Boyd","year":"1956","unstructured":"Boyd IA, Martin AR (1956) The end-plate potential in mammalian muscle. J Physiol 132(1):74\u201391","journal-title":"J Physiol"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1113\/jphysiol.1980.sp013145","volume":"299","author":"SG Cull-Candy","year":"1980","unstructured":"Cull-Candy SG, Miledi R, Trautmann A, Uchitel OD (1980) On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates. J Physiol 299:621\u2013638","journal-title":"J Physiol"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev-physiol-021014-071740","volume":"77","author":"GW Davis","year":"2015","unstructured":"Davis GW, Muller M (2015) Homeostatic control of presynaptic neurotransmitter release. Annu Rev Physiol 77:251\u2013270","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"5_CR7","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1113\/jphysiol.1954.sp005129","volume":"124","author":"J Del Castillo","year":"1954","unstructured":"Del Castillo J, Katz B (1954) Quantal components of the end-plate potential. J Physiol 124(3):560\u2013573","journal-title":"J Physiol"},{"issue":"5956","key":"5_CR8","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1126\/science.1179685","volume":"326","author":"DK Dickman","year":"2009","unstructured":"Dickman DK, Davis GW (2009) The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science 326(5956):1127\u20131130","journal-title":"Science"},{"issue":"9","key":"5_CR9","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1523\/JNEUROSCI.19-09-03384.1999","volume":"19","author":"KL Engisch","year":"1999","unstructured":"Engisch KL, Rich MM, Cook N, Nowycky MC (1999) Lambert-Eaton antibodies inhibit Ca2+ currents but paradoxically increase exocytosis during stimulus trains in bovine adrenal chromaffin cells. J Neurosci 19(9):3384\u20133395","journal-title":"J Neurosci"},{"issue":"7","key":"5_CR10","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/nn.4561","volume":"20","author":"EV Fletcher","year":"2017","unstructured":"Fletcher EV, Simon CM, Pagiazitis JG, Chalif JI, Vukojicic A, Drobac E, Wang X, Mentis GZ (2017) Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Nat Neurosci 20(7):905\u2013916","journal-title":"Nat Neurosci"},{"issue":"5","key":"5_CR11","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1152\/jn.1986.55.5.931","volume":"55","author":"RC Foehring","year":"1986","unstructured":"Foehring RC, Sypert GW, Munson JB (1986a) Properties of self-reinnervated motor units of medial gastrocnemius of cat. I. Long-term reinnervation. J Neurophysiol 55(5):931\u2013946","journal-title":"J Neurophysiol"},{"issue":"5","key":"5_CR12","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1152\/jn.1986.55.5.947","volume":"55","author":"RC Foehring","year":"1986","unstructured":"Foehring RC, Sypert GW, Munson JB (1986b) Properties of self-reinnervated motor units of medial gastrocnemius of cat. II. Axotomized motoneurons and time course of recovery. J Neurophysiol 55(5):947\u2013965","journal-title":"J Neurophysiol"},{"issue":"1","key":"5_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0022-510X(82)90225-8","volume":"54","author":"PE Gallant","year":"1982","unstructured":"Gallant PE (1982) The relationship between anti-acetylcholine receptor antibody levels and neuromuscular function in chronically myasthenic rats. J Neurol Sci 54(1):129\u2013141","journal-title":"J Neurol Sci"},{"issue":"27","key":"5_CR14","doi-asserted-by":"publisher","first-page":"7268","DOI":"10.1523\/JNEUROSCI.4066-15.2016","volume":"36","author":"MA Garcia-Bereguiain","year":"2016","unstructured":"Garcia-Bereguiain MA, Gonzalez-Islas C, Lindsly C, Wenner P (2016) Spontaneous release regulates synaptic scaling in the embryonic spinal network in vivo. J Neurosci 36(27):7268\u20137282","journal-title":"J Neurosci"},{"key":"5_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1113\/jphysiol.1984.sp015245","volume":"351","author":"AJ Gibb","year":"1984","unstructured":"Gibb AJ, Marshall IG (1984) Pre-and post-junctional effects of tubocurarine and other nicotinic antagonists during repetitive stimulation in the rat. J Physiol 351:275\u2013297","journal-title":"J Physiol"},{"issue":"2","key":"5_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1113\/jphysiol.1979.sp012784","volume":"290","author":"MI Glavinovic","year":"1979","unstructured":"Glavinovic MI (1979) Voltage clamping of unparalysed cut rat diaphragm for study of transmitter release. J Physiol 290(2):467\u2013480","journal-title":"J Physiol"},{"issue":"3","key":"5_CR17","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/jnr.24138","volume":"96","author":"C Gonzalez-Islas","year":"2018","unstructured":"Gonzalez-Islas C, Bulow P, Wenner P (2018) Regulation of synaptic scaling by action potential-independent miniature neurotransmission. J Neurosci Res 96(3):348\u2013353","journal-title":"J Neurosci Res"},{"issue":"6","key":"5_CR18","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1440-1681.1988.tb01104.x","volume":"15","author":"AJ Harborne","year":"1988","unstructured":"Harborne AJ, Bowman WC, Marshall IG (1988) Effects of tubocurarine on end-plate current rundown and quantal content during rapid nerve stimulation in the snake. Clin Exp Pharmacol Physiol 15(6):479\u2013490","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"5_CR19","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.neuron.2015.10.049","volume":"88","author":"N Harris","year":"2015","unstructured":"Harris N, Braiser DJ, Dickman DK, Fetter RD, Tong A, Davis GW (2015) The innate immune receptor PGRP-LC controls presynaptic homeostatic plasticity. Neuron 88(6):1157\u20131164","journal-title":"Neuron"},{"issue":"5","key":"5_CR20","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.neuron.2018.09.048","volume":"100","author":"N Harris","year":"2018","unstructured":"Harris N, Fetter RD, Brasier DJ, Tong A, Davis GW (2018) Molecular interface of neuronal innate immunity, synaptic vesicle stabilization, and presynaptic homeostatic plasticity. Neuron 100(5):1163\u20131179 e1164","journal-title":"Neuron"},{"issue":"3","key":"5_CR21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1083\/jcb.88.3.564","volume":"88","author":"JE Heuser","year":"1981","unstructured":"Heuser JE, Reese TS (1981) Structural changes after transmitter release at the frog neuromuscular junction. J Cell Biol 88(3):564\u2013580","journal-title":"J Cell Biol"},{"issue":"2","key":"5_CR22","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1083\/jcb.81.2.275","volume":"81","author":"JE Heuser","year":"1979","unstructured":"Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L, Evans L (1979) Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol 81(2):275\u2013300","journal-title":"J Cell Biol"},{"issue":"4","key":"5_CR23","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/j.1476-5381.1991.tb12258.x","volume":"102","author":"SJ Hong","year":"1991","unstructured":"Hong SJ, Chang CC (1991) Run-down of neuromuscular transmission during repetitive nerve activity by nicotinic antagonists is not due to desensitization of the postsynaptic receptor. Br J Pharmacol 102(4):817\u2013822","journal-title":"Br J Pharmacol"},{"issue":"1","key":"5_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn3875","volume":"16","author":"ET Kavalali","year":"2015","unstructured":"Kavalali ET (2015) The mechanisms and functions of spontaneous neurotransmitter release. Nat Rev Neurosci 16(1):5\u201316","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"5_CR25","first-page":"45","volume":"26","author":"ET Kavalali","year":"2011","unstructured":"Kavalali ET, Chung C, Khvotchev M, Leitz J, Nosyreva E, Raingo J, Ramirez DM (2011) Spontaneous neurotransmission: an independent pathway for neuronal signaling? Physiology (Bethesda) 26(1):45\u201353","journal-title":"Physiology (Bethesda)"},{"key":"5_CR26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1113\/jphysiol.1987.sp016504","volume":"385","author":"SS Kelly","year":"1987","unstructured":"Kelly SS, Robbins N (1987) Statistics of neuromuscular transmitter release in young and old mouse muscle. J Physiol 385:507\u2013516","journal-title":"J Physiol"},{"issue":"34","key":"5_CR27","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.1523\/JNEUROSCI.0313-17.2017","volume":"37","author":"A Khedraki","year":"2017","unstructured":"Khedraki A, Reed EJ, Romer SH, Wang Q, Romine W, Rich MM, Talmadge RJ, Voss AA (2017) Depressed synaptic transmission and reduced vesicle release sites in Huntington\u2019s disease neuromuscular junctions. J Neurosci 37(34):8077\u20138091","journal-title":"J Neurosci"},{"issue":"3","key":"5_CR28","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1523\/JNEUROSCI.4434-08.2009","volume":"29","author":"L Kong","year":"2009","unstructured":"Kong L, Wang X, Choe DW, Polley M, Burnett BG, Bosch-Marce M, Griffin JW, Rich MM, Sumner CJ (2009) Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 29(3):842\u2013851","journal-title":"J Neurosci"},{"issue":"10","key":"5_CR29","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0166-2236(91)90042-S","volume":"14","author":"H Korn","year":"1991","unstructured":"Korn H, Faber DS (1991) Quantal analysis and synaptic efficacy in the CNS. Trends Neurosci 14(10):439\u2013445","journal-title":"Trends Neurosci"},{"key":"5_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1113\/jphysiol.1981.sp013618","volume":"312","author":"KL Magleby","year":"1981","unstructured":"Magleby KL, Pallotta BS, Terrar DA (1981) The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog. J Physiol 312:97\u2013113","journal-title":"J Physiol"},{"issue":"25","key":"5_CR31","doi-asserted-by":"publisher","first-page":"8703","DOI":"10.1523\/JNEUROSCI.0204-12.2012","volume":"32","author":"TL Martinez","year":"2012","unstructured":"Martinez TL, Kong L, Wang X, Osborne MA, Crowder ME, Van Meerbeke JP, Xu X, Davis C, Wooley J, Goldhamer DJ, Lutz CM, Rich MM, Sumner CJ (2012) Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy. J Neurosci 32(25):8703\u20138715","journal-title":"J Neurosci"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1113\/jphysiol.1988.sp017032","volume":"398","author":"H Matzner","year":"1988","unstructured":"Matzner H, Parnas H, Parnas I (1988) Presynaptic effects of d-tubocurarine on neurotransmitter release at the neuromuscular junction of the frog. J Physiol 398:109\u2013121","journal-title":"J Physiol"},{"issue":"3","key":"5_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/mus.21099","volume":"39","author":"TA Mays","year":"2009","unstructured":"Mays TA, Sanford JL, Hanada T, Chishti AH, Rafael-Fortney JA (2009) Glutamate receptors localize postsynaptically at neuromuscular junctions in mice. Muscle Nerve 39(3):343\u2013349","journal-title":"Muscle Nerve"},{"key":"5_CR34","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1113\/jphysiol.1981.sp013586","volume":"311","author":"EM McLachlan","year":"1981","unstructured":"McLachlan EM, Martin AR (1981) Non-linear summation of end-plate potentials in the frog and mouse. J Physiol 311:307\u2013324","journal-title":"J Physiol"},{"issue":"1","key":"5_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1085\/jgp.201611603","volume":"149","author":"DR Miranda","year":"2017","unstructured":"Miranda DR, Wong M, Romer SH, McKee C, Garza-Vasquez G, Medina AC, Bahn V, Steele AD, Talmadge RJ, Voss AA (2017) Progressive Cl- channel defects reveal disrupted skeletal muscle maturation in R6\/2 Huntington\u2019s mice. J Gen Physiol 149(1):55\u201374","journal-title":"J Gen Physiol"},{"issue":"1","key":"5_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1113\/jphysiol.1975.sp011045","volume":"250","author":"MD Miyamoto","year":"1975","unstructured":"Miyamoto MD (1975) Binomial analysis of quantal transmitter release at glycerol treated frog neuromuscular junctions. J Physiol 250(1):121\u2013142","journal-title":"J Physiol"},{"key":"5_CR37","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0079-6123(08)64657-9","volume":"49","author":"PC Molenaar","year":"1979","unstructured":"Molenaar PC, Polak RL, Miledi R, Alema S, Vincent A, Newsom-Davis J (1979) Acetylcholine in intercostal muscle from myasthenia gravis patients and in rat diaphragm after blockade of acetylcholine receptors. Prog Brain Res 49:449\u2013458","journal-title":"Prog Brain Res"},{"issue":"1","key":"5_CR38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0014-2999(91)90413-K","volume":"196","author":"PC Molenaar","year":"1991","unstructured":"Molenaar PC, Oen BS, Plomp JJ, Van Kempen GT, Jennekens FG, Hesselmans LF (1991) A non-immunogenic myasthenia gravis model and its application in a study of transsynaptic regulation at the neuromuscular junction. Eur J Pharmacol 196(1):93\u2013101","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"5_CR39","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.cub.2012.04.018","volume":"22","author":"M Muller","year":"2012","unstructured":"Muller M, Davis GW (2012) Transsynaptic control of presynaptic Ca(2)(+) influx achieves homeostatic potentiation of neurotransmitter release. Curr Biol 22(12):1102\u20131108","journal-title":"Curr Biol"},{"issue":"47","key":"5_CR40","doi-asserted-by":"publisher","first-page":"16574","DOI":"10.1523\/JNEUROSCI.0981-12.2012","volume":"32","author":"M Muller","year":"2012","unstructured":"Muller M, Liu KS, Sigrist SJ, Davis GW (2012) RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool. J Neurosci 32(47):16574\u201316585","journal-title":"J Neurosci"},{"issue":"9","key":"5_CR41","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1523\/JNEUROSCI.5065-04.2005","volume":"25","author":"ST Nakanishi","year":"2005","unstructured":"Nakanishi ST, Cope TC, Rich MM, Carrasco DI, Pinter MJ (2005) Regulation of motoneuron excitability via motor endplate acetylcholine receptor activation. J Neurosci 25(9):2226\u20132232","journal-title":"J Neurosci"},{"issue":"5","key":"5_CR42","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0896-6273(00)80624-8","volume":"21","author":"RJ O\u2019Brien","year":"1998","unstructured":"O\u2019Brien RJ, Kamboj S, Ehlers MD, Rosen KR, Fischbach GD, Huganir RL (1998) Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 21(5):1067\u20131078","journal-title":"Neuron"},{"issue":"7674","key":"5_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature24017","volume":"550","author":"BO Orr","year":"2017","unstructured":"Orr BO, Fetter RD, Davis GW (2017) Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity. Nature 550(7674):109\u2013113","journal-title":"Nature"},{"issue":"34","key":"5_CR44","doi-asserted-by":"publisher","first-page":"8783","DOI":"10.1523\/JNEUROSCI.1181-16.2016","volume":"36","author":"KE Personius","year":"2016","unstructured":"Personius KE, Slusher BS, Udin SB (2016) Neuromuscular NMDA receptors modulate developmental synapse elimination. J Neurosci 36(34):8783\u20138789","journal-title":"J Neurosci"},{"issue":"2","key":"5_CR45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1152\/jn.1989.62.2.311","volume":"62","author":"MJ Pinter","year":"1989","unstructured":"Pinter MJ, Vanden Noven S (1989) Effects of preventing reinnervation on axotomized spinal motoneurons in the cat. I. Motoneuron electrical properties. J Neurophysiol 62(2):311\u2013324","journal-title":"J Neurophysiol"},{"issue":"3","key":"5_CR46","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1523\/JNEUROSCI.11-03-00657.1991","volume":"11","author":"MJ Pinter","year":"1991","unstructured":"Pinter MJ, Vanden Noven S, Muccio D, Wallace N (1991) Axotomy-like changes in cat motoneuron electrical properties elicited by botulinum toxin depend on the complete elimination of neuromuscular transmission. J Neurosci 11(3):657\u2013666","journal-title":"J Neurosci"},{"key":"5_CR47","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.2741\/4532","volume":"22","author":"JJ Plomp","year":"2017","unstructured":"Plomp JJ (2017) Trans-synaptic homeostasis at the myasthenic neuromuscular junction. Front Biosci (Landmark Ed) 22:1033\u20131051","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"Pt 1","key":"5_CR48","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1113\/jphysiol.1996.sp021373","volume":"493","author":"JJ Plomp","year":"1996","unstructured":"Plomp JJ, Molenaar PC (1996) Involvement of protein kinases in the upregulation of acetylcholine release at endplates of alpha-bungarotoxin-treated rats. J Physiol 493(Pt 1):175\u2013186","journal-title":"J Physiol"},{"key":"5_CR49","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1113\/jphysiol.1992.sp019429","volume":"458","author":"JJ Plomp","year":"1992","unstructured":"Plomp JJ, van Kempen GT, Molenaar PC (1992) Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha-bungarotoxin-treated rats. J Physiol 458:487\u2013499","journal-title":"J Physiol"},{"issue":"Pt 1","key":"5_CR50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1113\/jphysiol.1994.sp020236","volume":"478","author":"JJ Plomp","year":"1994","unstructured":"Plomp JJ, van Kempen GT, Molenaar PC (1994) The upregulation of acetylcholine release at endplates of alpha-bungarotoxin-treated rats: its dependency on calcium. J Physiol 478(Pt 1):125\u2013136","journal-title":"J Physiol"},{"issue":"5","key":"5_CR51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/ana.410370513","volume":"37","author":"JJ Plomp","year":"1995","unstructured":"Plomp JJ, Van Kempen GT, De Baets MB, Graus YM, Kuks JB, Molenaar PC (1995) Acetylcholine release in myasthenia gravis: regulation at single end-plate level. Ann Neurol 37(5):627\u2013636","journal-title":"Ann Neurol"},{"issue":"3","key":"5_CR52","doi-asserted-by":"publisher","first-page":"100","DOI":"10.32607\/20758251-2018-10-3-100-102","volume":"10","author":"SE Proskurina","year":"2018","unstructured":"Proskurina SE, Petrov KA, Nikolsky EE (2018) Influence of the activation of NMDA receptors on the resting membrane potential of the Postsynaptic cell at the neuromuscular junction. Acta Nat 10(3):100\u2013102","journal-title":"Acta Nat"},{"issue":"4 Pt 1","key":"5_CR53","doi-asserted-by":"publisher","first-page":"C1051","DOI":"10.1152\/ajpcell.1993.264.4.C1051","volume":"264","author":"SD Provan","year":"1993","unstructured":"Provan SD, Miyamoto MD (1993) Unbiased estimates of quantal release parameters and spatial variation in the probability of neurosecretion. Am J Phys 264(4 Pt 1):C1051\u2013C1060","journal-title":"Am J Phys"},{"issue":"1","key":"5_CR54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/physrev.1990.70.1.165","volume":"70","author":"S Redman","year":"1990","unstructured":"Redman S (1990) Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiol Rev 70(1):165\u2013198","journal-title":"Physiol Rev"},{"issue":"2","key":"5_CR55","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1177\/1073858405281898","volume":"12","author":"MM Rich","year":"2006","unstructured":"Rich MM (2006) The control of neuromuscular transmission in health and disease. Neuroscientist 12(2):134\u2013142","journal-title":"Neuroscientist"},{"issue":"3","key":"5_CR56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tins.2007.01.004","volume":"30","author":"MM Rich","year":"2007","unstructured":"Rich MM, Wenner P (2007) Sensing and expressing homeostatic synaptic plasticity. Trends Neurosci 30(3):119\u2013125","journal-title":"Trends Neurosci"},{"issue":"1","key":"5_CR57","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1523\/JNEUROSCI.12-01-00297.1992","volume":"12","author":"R Robitaille","year":"1992","unstructured":"Robitaille R, Charlton MP (1992) Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels. J Neurosci 12(1):297\u2013305","journal-title":"J Neurosci"},{"issue":"3","key":"5_CR58","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1523\/JNEUROSCI.4496-09.2010","volume":"30","author":"R Ruiz","year":"2010","unstructured":"Ruiz R, Casanas JJ, Torres-Benito L, Cano R, Tabares L (2010) Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. J Neurosci 30(3):849\u2013857","journal-title":"J Neurosci"},{"issue":"6","key":"5_CR59","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1523\/JNEUROSCI.4663-10.2011","volume":"31","author":"R Ruiz","year":"2011","unstructured":"Ruiz R, Cano R, Casanas JJ, Gaffield MA, Betz WJ, Tabares L (2011) Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse. J Neurosci 31(6):2000\u20132008","journal-title":"J Neurosci"},{"issue":"2","key":"5_CR60","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0896-6273(00)80789-8","volume":"23","author":"R Schneggenburger","year":"1999","unstructured":"Schneggenburger R, Meyer AC, Neher E (1999) Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse. Neuron 23(2):399\u2013409","journal-title":"Neuron"},{"issue":"Pt 3","key":"5_CR61","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1113\/jphysiol.2001.013129","volume":"539","author":"TJ Searl","year":"2002","unstructured":"Searl TJ, Silinsky EM (2002) Evidence for two distinct processes in the final stages of neurotransmitter release as detected by binomial analysis in calcium and strontium solutions. J Physiol 539(Pt 3):693\u2013705","journal-title":"J Physiol"},{"issue":"2","key":"5_CR62","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0896-6273(03)00643-3","volume":"40","author":"CF Stevens","year":"2003","unstructured":"Stevens CF (2003) Neurotransmitter release at central synapses. Neuron 40(2):381\u2013388","journal-title":"Neuron"},{"issue":"1","key":"5_CR63","first-page":"260","volume":"227","author":"RH Thomsen","year":"1983","unstructured":"Thomsen RH, Wilson DF (1983) Effects of 4-aminopyridine and 3,4-diaminopyridine on transmitter release at the neuromuscular junction. J Pharmacol Exp Ther 227(1):260\u2013265","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"5_CR64","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1113\/jphysiol.1994.sp020151","volume":"476","author":"L Tian","year":"1994","unstructured":"Tian L, Prior C, Dempster J, Marshall IG (1994) Nicotinic antagonist-produced frequency-dependent changes in acetylcholine release from rat motor nerve terminals. J Physiol 476(3):517\u2013529","journal-title":"J Physiol"},{"issue":"6","key":"5_CR65","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/sj.bjp.0701481","volume":"122","author":"L Tian","year":"1997","unstructured":"Tian L, Prior C, Dempster J, Marshall IG (1997) Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals. Br J Pharmacol 122(6):1025\u20131034","journal-title":"Br J Pharmacol"},{"issue":"6670","key":"5_CR66","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/36103","volume":"391","author":"GG Turrigiano","year":"1998","unstructured":"Turrigiano GG, Leslie KR, Desai NS, Rutherford LC, Nelson SB (1998) Activity-dependent scaling of quantal amplitude in neocortical neurons. Nature 391(6670):892\u2013896","journal-title":"Nature"},{"issue":"12","key":"5_CR67","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/0166-2236(89)90109-4","volume":"12","author":"A Vincent","year":"1989","unstructured":"Vincent A, Lang B, Newsom-Davis J (1989) Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder. Trends Neurosci 12(12):496\u2013502","journal-title":"Trends Neurosci"},{"issue":"1","key":"5_CR68","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/nyas.13472","volume":"1412","author":"X Wang","year":"2018","unstructured":"Wang X, Rich MM (2018) Homeostatic synaptic plasticity at the neuromuscular junction in myasthenia gravis. Ann N Y Acad Sci 1412(1):170\u2013177","journal-title":"Ann N Y Acad Sci"},{"issue":"47","key":"5_CR69","doi-asserted-by":"publisher","first-page":"10687","DOI":"10.1523\/JNEUROSCI.2755-04.2004","volume":"24","author":"X Wang","year":"2004","unstructured":"Wang X, Engisch KL, Li Y, Pinter MJ, Cope TC, Rich MM (2004) Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo. J Neurosci 24(47):10687\u201310692","journal-title":"J Neurosci"},{"issue":"2","key":"5_CR70","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1523\/JNEUROSCI.3252-04.2005","volume":"25","author":"X Wang","year":"2005","unstructured":"Wang X, Li Y, Engisch KL, Nakanishi ST, Dodson SE, Miller GW, Cope TC, Pinter MJ, Rich MM (2005) Activity-dependent presynaptic regulation of quantal size at the mammalian neuromuscular junction in vivo. J Neurosci 25(2):343\u2013351","journal-title":"J Neurosci"},{"issue":"16","key":"5_CR71","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.1113\/jphysiol.2008.151191","volume":"586","author":"X Wang","year":"2008","unstructured":"Wang X, Thiagarajan R, Wang Q, Tewolde T, Rich MM, Engisch KL (2008) Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism. J Physiol 586(16):3949\u20133962","journal-title":"J Physiol"},{"issue":"2","key":"5_CR72","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1152\/jn.00708.2009","volume":"103","author":"X Wang","year":"2010","unstructured":"Wang X, Pinter MJ, Rich MM (2010a) Ca2+ dependence of the binomial parameters p and n at the mouse neuromuscular junction. J Neurophysiol 103(2):659\u2013666","journal-title":"J Neurophysiol"},{"issue":"5","key":"5_CR73","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1152\/jn.00460.2010","volume":"104","author":"X Wang","year":"2010","unstructured":"Wang X, Wang Q, Engisch KL, Rich MM (2010b) Activity-dependent regulation of the binomial parameters p and n at the mouse neuromuscular junction in vivo. J Neurophysiol 104(5):2352\u20132358","journal-title":"J Neurophysiol"},{"issue":"10","key":"5_CR74","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1523\/JNEUROSCI.5278-10.2011","volume":"31","author":"X Wang","year":"2011","unstructured":"Wang X, Wang Q, Yang S, Bucan M, Rich MM, Engisch KL (2011) Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice. J Neurosci 31(10):3580\u20133588","journal-title":"J Neurosci"},{"issue":"3","key":"5_CR75","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuron.2014.07.003","volume":"83","author":"T Wang","year":"2014","unstructured":"Wang T, Hauswirth AG, Tong A, Dickman DK, Davis GW (2014) Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity. Neuron 83(3):616\u2013629","journal-title":"Neuron"},{"issue":"3","key":"5_CR76","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1523\/JNEUROSCI.3786-15.2016","volume":"36","author":"X Wang","year":"2016","unstructured":"Wang X, Pinter MJ, Rich MM (2016) Reversible recruitment of a homeostatic reserve pool of synaptic vesicles underlies rapid homeostatic plasticity of quantal content. J Neurosci 36(3):828\u2013836","journal-title":"J Neurosci"},{"issue":"7","key":"5_CR77","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1523\/JNEUROSCI.1789-17.2018","volume":"38","author":"X Wang","year":"2018","unstructured":"Wang X, McIntosh JM, Rich MM (2018) Muscle Nicotinic Acetylcholine receptors may mediate trans-synaptic signaling at the mouse neuromuscular junction. J Neurosci 38(7):1725\u20131736","journal-title":"J Neurosci"},{"issue":"22","key":"5_CR78","doi-asserted-by":"publisher","first-page":"9160","DOI":"10.1073\/pnas.1220068110","volume":"110","author":"CW Waters","year":"2013","unstructured":"Waters CW, Varuzhanyan G, Talmadge RJ, Voss AA (2013) Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction. Proc Natl Acad Sci U S A 110(22):9160\u20139165","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"5_CR79","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1113\/jphysiol.1975.sp010792","volume":"244","author":"A Wernig","year":"1975","unstructured":"Wernig A (1975) Estimates of statistical release parameters from crayfish and frog neuromuscular junctions. J Physiol 244(1):207\u2013221","journal-title":"J Physiol"},{"issue":"5","key":"5_CR80","doi-asserted-by":"publisher","first-page":"C366","DOI":"10.1152\/ajpcell.1982.242.5.C366","volume":"242","author":"DF Wilson","year":"1982","unstructured":"Wilson DF (1982) Influence of presynaptic receptors on neuromuscular transmission in rat. Am J Physiol 242(5):C366\u2013C372","journal-title":"Am J Physiol"},{"issue":"2","key":"5_CR81","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0304-3940(91)90292-2","volume":"132","author":"DF Wilson","year":"1991","unstructured":"Wilson DF, Thomsen RH (1991) Nicotinic receptors on the rat phrenic nerve: evidence for negative feedback. Neurosci Lett 132(2):163\u2013166","journal-title":"Neurosci Lett"},{"issue":"1","key":"5_CR82","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0304-3940(95)11274-Z","volume":"186","author":"DF Wilson","year":"1995","unstructured":"Wilson DF, West AE, Lin Y (1995) Inhibitory action of nicotinic antagonists on transmitter release at the neuromuscular junction of the rat. Neurosci Lett 186(1):29\u201332","journal-title":"Neurosci Lett"},{"issue":"Pt 1","key":"5_CR83","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1113\/jphysiol.1997.sp022007","volume":"500","author":"SJ Wood","year":"1997","unstructured":"Wood SJ, Slater CR (1997) The contribution of postsynaptic folds to the safety factor for neuromuscular transmission in rat fast- and slow-twitch muscles. J Physiol 500(Pt 1):165\u2013176","journal-title":"J Physiol"},{"issue":"6","key":"5_CR84","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.neuron.2013.06.048","volume":"79","author":"MA Younger","year":"2013","unstructured":"Younger MA, Muller M, Tong A, Pym EC, Davis GW (2013) A presynaptic ENaC channel drives homeostatic plasticity. Neuron 79(6):1183\u20131196","journal-title":"Neuron"}],"container-title":["Advances in Neurobiology","Vertebrate Motoneurons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-07167-6_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T15:31:41Z","timestamp":1662478301000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-07167-6_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031071669","9783031071676"],"references-count":84,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-07167-6_5","relation":{},"ISSN":["2190-5215","2190-5223"],"issn-type":[{"value":"2190-5215","type":"print"},{"value":"2190-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"7 September 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}