{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:43:27Z","timestamp":1748591007146,"version":"3.40.3"},"publisher-location":"Cham","reference-count":25,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031105357"},{"type":"electronic","value":"9783031105364"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-10536-4_21","type":"book-chapter","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T07:03:10Z","timestamp":1658473390000},"page":"308-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Influence of\u00a0Amyloid-Beta on\u00a0Calcium Dynamics in\u00a0Alzheimer\u2019s Disease: A Spatio-Temporal Study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-7338","authenticated-orcid":false,"given":"Swadesh","family":"Pal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-6792","authenticated-orcid":false,"given":"Hina","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-6684","authenticated-orcid":false,"given":"Roderick","family":"Melnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"21_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brain.2021.100039","volume":"2","author":"A Sch\u00e4fer","year":"2021","unstructured":"Sch\u00e4fer, A., et al.: Predicting brain atrophy from tau pathology: a summary of clinical findings and their translation into personalized models. J Brain Multiphys. 2, 100039 (2021)","journal-title":"J Brain Multiphys."},{"key":"21_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202503","volume":"13","author":"J Latulippe","year":"2018","unstructured":"Latulippe, J., Lotito, D., Murby, D.: A mathematical model for the effects of amyloid beta on intracellular calcium. PLoS ONE 13, e0202503 (2018)","journal-title":"PLoS ONE"},{"key":"21_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fncom.2021.653097","volume":"15","author":"H Shaheen","year":"2021","unstructured":"Shaheen, H., Singh, S., Melnik, R.: A neuron-glial model of exosomal release in the onset and progression of Alzheimer\u2019s disease. Front. Comput. Neurosci. 15, 79 (2021)","journal-title":"Front. Comput. Neurosci."},{"key":"21_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.767892","volume":"12","author":"L Liu","year":"2021","unstructured":"Liu, L., Gao, H., Zaikin, A., Chen, S.: Unraveling A$$\\beta $$-mediated multi-pathway calcium dynamics in astrocytes: implications for Alzheimer\u2019s Disease treatment from simulations. Front. Physiol. 12, 767892 (2021)","journal-title":"Front. Physiol."},{"issue":"10","key":"21_CR5","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00424-019-02310-2","volume":"471","author":"A Verkhratsky","year":"2019","unstructured":"Verkhratsky, A., et al.: Astroglial atrophy in Alzheimer\u2019s disease. Pfl\u00fcgers Archiv-Eur. J. Physiol. 471(10), 1247\u20131261 (2019)","journal-title":"Pfl\u00fcgers Archiv-Eur. J. Physiol."},{"issue":"4","key":"21_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10867-009-9155-y","volume":"35","author":"M De Pitt\u00e0","year":"2009","unstructured":"De Pitt\u00e0, M., et al.: Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes. J. Biol. Phys. 35(4), 383\u2013411 (2009)","journal-title":"J. Biol. Phys."},{"issue":"17","key":"21_CR7","doi-asserted-by":"publisher","first-page":"12463","DOI":"10.1074\/jbc.R109.080895","volume":"285","author":"A Demuro","year":"2010","unstructured":"Demuro, A., Parker, I., Stutzmann, G.E.: Calcium signaling and amyloid toxicity in Alzheimer disease. J. Biol. Chem. 285(17), 12463\u201312468 (2010)","journal-title":"J. Biol. Chem."},{"key":"21_CR8","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/glia.22502","volume":"61","author":"D Lim","year":"2013","unstructured":"Lim, D., et al.: Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB. Glia 61, 1134\u20131145 (2013)","journal-title":"Glia"},{"key":"21_CR9","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1016\/S0006-3495(95)80088-3","volume":"69","author":"MS Jafri","year":"1995","unstructured":"Jafri, M.S., Keizer, J.: On the Roles of Ca$$^{2+}$$ Diffusion, Ca$$^{2+}$$ Buffers, and the Endoplasmic Reticulum in IP$$_3$$-lnduced Ca$$^{2+}$$ Waves. Biophys. J . 69, 2139\u20132153 (1995)","journal-title":"Biophys. J ."},{"key":"21_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41583-020-0361-8","volume":"21","author":"A Semyanov","year":"2020","unstructured":"Semyanov, A., Henneberger, C., Agarwal, A.: Making sense of astrocytic calcium signals-from acquisition to interpretation. Nat. Rev. Neurosci. 21, 551\u2013564 (2020)","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"21_CR11","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.neuron.2008.09.004","volume":"59","author":"C Agulhon","year":"2008","unstructured":"Agulhon, C., et al.: What is the role of astrocyte calcium in neurophysiology? Neuron 59(6), 932\u2013946 (2008)","journal-title":"Neuron"},{"issue":"3","key":"21_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ceca.2005.10.009","volume":"39","author":"G Ullah","year":"2006","unstructured":"Ullah, G., Jung, P., Cornell-Bell, A.H.: Anti-phase calcium oscillations in astrocytes via inositol (1, 4, 5)-trisphosphate regeneration. Cell Calcium 39(3), 197\u2013208 (2006)","journal-title":"Cell Calcium"},{"key":"21_CR13","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/acel.12054","volume":"12","author":"E Alberdi","year":"2013","unstructured":"Alberdi, E., et al.: Ca$$^{2+}$$-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid $$\\beta $$-treated astrocytes and in a model of Alzheimer\u2019s disease. Aging Cell 12, 292\u2013302 (2013)","journal-title":"Aging Cell"},{"key":"21_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroscience.2019.09.041","volume":"421","author":"VS Alves","year":"2019","unstructured":"Alves, V.S., et al.: Calcium signaling in neurons and glial cells: role of Cav1 channels. Neuroscience 421, 95\u2013111 (2019)","journal-title":"Neuroscience"},{"key":"21_CR15","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/S0006-3495(93)81191-3","volume":"65","author":"A Atri","year":"1993","unstructured":"Atri, A., et al.: A single-pool model for intracellular calcium oscillations and waves in the Xenopus Laevis oocyte. Biophys. J . 65, 1727\u20131739 (1993)","journal-title":"Biophys. J ."},{"key":"21_CR16","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1126\/science.8385800","volume":"260","author":"P Camacho","year":"1993","unstructured":"Camacho, P., Lechleiter, J.D.: Increased frequency of calcium waves in Xenopus Laevis oocytes that express a calcium-ATPase. Science 260, 226\u2013229 (1993)","journal-title":"Science"},{"key":"21_CR17","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/0896-6273(91)90238-U","volume":"6","author":"AC Charles","year":"1991","unstructured":"Charles, A.C., Merrill, J.E., Dirksen, E.R., Sanderson, M.J.: Intercellular signalling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate. Neuron 6, 983\u2013992 (1991)","journal-title":"Neuron"},{"key":"21_CR18","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1097\/00001756-200112210-00008","volume":"12","author":"HR Parri","year":"2001","unstructured":"Parri, H.R., Crunelli, V.: Pacemaker calcium oscillations in thalamic astrocytes in situ. NeuroReport 12, 3897\u20133900 (2001)","journal-title":"NeuroReport"},{"key":"21_CR19","unstructured":"Vassilis, C., Moustafa, A.A.: Neurocomputational models of Alzheimer\u2019s disease. Scholarpedia (2017)"},{"issue":"2","key":"21_CR20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/acel.12054","volume":"12","author":"E Alberdi","year":"2013","unstructured":"Alberdi, E., Wyssenbach, A., Alberdi, M., S\u00e1nchez-G\u00f3mez, M.V., Cavaliere, F., Rodr\u00edguez, J.J., Verkhratsky, A., Matute, C.: Ca$$^{2+}$$-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid $$\\beta $$-treated astrocytes and in a model of Alzheimer\u2019s disease. Aging Cell 12(2), 292\u2013302 (2013)","journal-title":"Aging Cell"},{"key":"21_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1196\/annals.1379.004","volume":"1097","author":"T Takano","year":"2007","unstructured":"Takano, T., et al.: Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer\u2019s disease. Ann. N. Y. Acad. Sci. 1097, 40\u201350 (2007)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"21_CR22","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/BF02071879","volume":"15","author":"S Anderson","year":"1995","unstructured":"Anderson, S., Brismar, T., Hansson, E.: Effect of external K$$^+$$, Ca$$^{2+}$$, and Ba$$^{2+}$$ on membrane potential and ionic conductance in rat astrocytes. Cell. Mol. Neurobiol. 15, 439\u2013450 (1995)","journal-title":"Cell. Mol. Neurobiol."},{"key":"21_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neubiorev.2017.03.002","volume":"77","author":"A Bellot-Saez","year":"2017","unstructured":"Bellot-Saez, A., Kekesi, O., Morley, J.W., Buskila, Y.: Astrocytic modulation of neuronal excitability through K$$^+$$ spatial buffering. Neurosci. Biobehav. Rev. 77, 87\u201397 (2017)","journal-title":"Neurosci. Biobehav. Rev."},{"key":"21_CR24","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/978-3-030-77977-1_42","volume-title":"Computational Science \u2013 ICCS 2021","author":"S Pal","year":"2021","unstructured":"Pal, S., Melnik, R.: Pathology dynamics in healthy-toxic protein interaction and the multiscale analysis of neurodegenerative diseases. In: Paszynski, M., Kranzlm\u00fcller, D., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M.A. (eds.) ICCS 2021. LNCS, vol. 12746, pp. 528\u2013540. Springer, Cham (2021). https:\/\/doi.org\/10.1007\/978-3-030-77977-1_42"},{"key":"21_CR25","doi-asserted-by":"publisher","first-page":"7328","DOI":"10.1038\/s41598-022-11242-4","volume":"12","author":"S Pal","year":"2022","unstructured":"Pal, S., Melnik, R.: Nonlocal models in the analysis of brain neurodegenerative protein dynamics with application to Alzheimer\u2019s disease. Sci. Rep. 12, 7328 (2022)","journal-title":"Sci. Rep."}],"container-title":["Lecture Notes in Computer Science","Computational Science and Its Applications \u2013 ICCSA 2022 Workshops"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-10536-4_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T19:08:13Z","timestamp":1668798493000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-10536-4_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031105357","9783031105364"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-10536-4_21","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"23 July 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ICCSA","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Computational Science and Its Applications","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Malaga","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2022","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"4 July 2022","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"7 July 2022","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"iccsa2022","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/iccsa.org\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"CyberChair 4","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"279","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"57","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"24","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"20% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"2.6","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"8.7","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"285 Workshop submission accepted out of 815 submissions","order":10,"name":"additional_info_on_review_process","label":"Additional Info on Review Process","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}