{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:58:55Z","timestamp":1782748735385,"version":"3.54.5"},"publisher-location":"Cham","reference-count":16,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031141898","type":"print"},{"value":"9783031141904","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-14190-4_15","type":"book-chapter","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:03:09Z","timestamp":1671260589000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non-invasive Detection of Persistent Cortical Hypoxia in Multiple Sclerosis Using Frequency Domain Near-Infrared Spectroscopy (fdNIRS)"],"prefix":"10.1007","author":[{"given":"Damilola D.","family":"Adingupu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soroush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"15_CR1","first-page":"15","volume-title":"Brain metabolic adaptations to hypoxia","author":"MA Puchowicz","year":"2008","unstructured":"Puchowicz MA, Koppaka SS, LaManna JC (2008) Brain metabolic adaptations to hypoxia. Springer, New York, pp 15\u201330"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"101343","DOI":"10.1016\/j.arr.2021.101343","volume":"68","author":"J Burtscher","year":"2021","unstructured":"Burtscher J, Mallet RT, Burtscher M, Millet GP (2021) Hypoxia and brain aging: neurodegeneration or neuroprotection? Ageing Res Rev 68:101343. https:\/\/doi.org\/10.1016\/j.arr.2021.101343","journal-title":"Ageing Res Rev"},{"issue":"Suppl 5","key":"15_CR3","doi-asserted-by":"publisher","first-page":"v3","DOI":"10.1007\/s00415-005-5002-7","volume":"252","author":"W Br\u00fcck","year":"2005","unstructured":"Br\u00fcck W (2005) The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. (in eng), J Neurol 252(Suppl 5):v3\u2013v9. https:\/\/doi.org\/10.1007\/s00415-005-5002-7","journal-title":"(in eng), J Neurol"},{"issue":"1","key":"15_CR4","doi-asserted-by":"publisher","first-page":"16477","DOI":"10.1038\/srep16477","volume":"5","author":"R Yang","year":"2015","unstructured":"Yang R, Dunn JF (2015) Reduced cortical microvascular oxygenation in multiple sclerosis: a blinded, case-controlled study using a novel quantitative near-infrared spectroscopy method. Sci Rep 5(1):16477. https:\/\/doi.org\/10.1038\/srep16477","journal-title":"Sci Rep"},{"issue":"2","key":"15_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/s0022-510x(02)00421-5","volume":"206","author":"H Lassmann","year":"2003","unstructured":"Lassmann H (2003) Hypoxia-like tissue injury as a component of multiple sclerosis lesions. J Neurol Sci 206(2):187\u2013191. https:\/\/doi.org\/10.1016\/s0022-510x(02)00421-5","journal-title":"J Neurol Sci"},{"issue":"6","key":"15_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/1531-8249(200006)47:6<707::aid-ana3>3.0.co;2-q","volume":"47","author":"C Lucchinetti","year":"2000","unstructured":"Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47(6):707\u2013717. https:\/\/doi.org\/10.1002\/1531-8249(200006)47:6<707::aid-ana3>3.0.co;2-q","journal-title":"Ann Neurol"},{"issue":"13","key":"15_CR7","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1177\/1352458518791683","volume":"25","author":"R Yang","year":"2019","unstructured":"Yang R, Dunn JF (2019) Multiple sclerosis disease progression: contributions from a hypoxia-inflammation cycle. (in eng), Mult Scler 25(13):1715\u20131718. https:\/\/doi.org\/10.1177\/1352458518791683","journal-title":"(in eng), Mult Scler"},{"issue":"12","key":"15_CR8","doi-asserted-by":"publisher","first-page":"e0167196","DOI":"10.1371\/journal.pone.0167196","volume":"11","author":"TW Johnson","year":"2016","unstructured":"Johnson TW, Wu Y, Nathoo N, Rogers JA, Wee Yong V, Dunn JF (2016) Gray matter hypoxia in the brain of the experimental autoimmune encephalomyelitis model of multiple sclerosis. PLoS One 11(12):e0167196. https:\/\/doi.org\/10.1371\/journal.pone.0167196","journal-title":"PLoS One"},{"issue":"6","key":"15_CR9","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/ana.24006","volume":"74","author":"AL Davies","year":"2013","unstructured":"Davies AL et al (Dec 2013) Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol 74(6):815\u2013825. https:\/\/doi.org\/10.1002\/ana.24006","journal-title":"Ann Neurol"},{"issue":"2","key":"15_CR10","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.neuroimage.2012.03.049","volume":"63","author":"M Ferrari","year":"2012","unstructured":"Ferrari M, Quaresima V (2012) A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. (in eng), Neuroimage 63(2):921\u2013935. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.03.049","journal-title":"(in eng), Neuroimage"},{"issue":"3","key":"15_CR11","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1088\/0031-9155\/44\/3\/015","volume":"44","author":"CD Kurth","year":"1999","unstructured":"Kurth CD, Thayer WS (1999) A multiwavelength frequency-domain near-infrared cerebral oximeter. (in eng), Phys Med Biol 44(3):727\u2013740. https:\/\/doi.org\/10.1088\/0031-9155\/44\/3\/015","journal-title":"(in eng), Phys Med Biol"},{"issue":"1","key":"15_CR12","doi-asserted-by":"publisher","first-page":"11008","DOI":"10.1117\/1.1854673","volume":"10","author":"E Gratton","year":"2005","unstructured":"Gratton E, Toronov V, Wolf U, Wolf M, Webb A (2005) Measurement of brain activity by near-infrared light. J Biomed Opt 10(1):11008. https:\/\/doi.org\/10.1117\/1.1854673","journal-title":"J Biomed Opt"},{"issue":"2","key":"15_CR13","doi-asserted-by":"publisher","first-page":"024028","DOI":"10.1117\/1.1891345","volume":"10","author":"J Zhao","year":"2005","unstructured":"Zhao J, Ding HS, Hou XL, Zhou CL, Chance B (2005) In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy. J Biomed Opt 10(2):024028. https:\/\/doi.org\/10.1117\/1.1891345","journal-title":"J Biomed Opt"},{"issue":"8","key":"15_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1364\/oe.9.000417","volume":"9","author":"V Toronov","year":"2001","unstructured":"Toronov V et al (2001) Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging. Opt Express 9(8):417\u2013427. https:\/\/doi.org\/10.1364\/oe.9.000417","journal-title":"Opt Express"},{"issue":"4","key":"15_CR15","doi-asserted-by":"publisher","first-page":"646","DOI":"10.4103\/1673-5374.266906","volume":"15","author":"MM Lagana","year":"2020","unstructured":"Lagana MM, Pelizzari L, Baglio F (2020) Relationship between MRI perfusion and clinical severity in multiple sclerosis. (in eng), Neural Regen Res 15(4):646\u2013652. https:\/\/doi.org\/10.4103\/1673-5374.266906","journal-title":"(in eng), Neural Regen Res"},{"issue":"12","key":"15_CR16","doi-asserted-by":"publisher","first-page":"205846011989421","DOI":"10.1177\/2058460119894214","volume":"8","author":"MJ de la Pena","year":"2019","unstructured":"de la Pena MJ et al (2019) Early perfusion changes in multiple sclerosis patients as assessed by MRI using arterial spin labeling. Acta Radiol Open 8(12):2058460119894214. https:\/\/doi.org\/10.1177\/2058460119894214","journal-title":"Acta Radiol Open"}],"container-title":["Advances in Experimental Medicine and Biology","Oxygen Transport to Tissue XLIII"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-14190-4_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T16:13:40Z","timestamp":1691165620000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-14190-4_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031141898","9783031141904"],"references-count":16,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-14190-4_15","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"18 December 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}