{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:47:19Z","timestamp":1765039639420,"version":"3.40.3"},"publisher-location":"Cham","reference-count":31,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031141898"},{"type":"electronic","value":"9783031141904"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-3-031-14190-4_19","type":"book-chapter","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:03:09Z","timestamp":1671260589000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heme Oxygenase-1\/High Mobility Group Box 1 Pathway May Have a Possible Role in COVID-19 ARDS (Acute Respiratory Distress Syndrome): A Pilot Histological Study"],"prefix":"10.1007","author":[{"given":"G.","family":"Cicco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sablone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cazzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cicco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ingravallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Introna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cossarizza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"issue":"1","key":"19_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40249-020-00646-x","volume":"9","author":"SP Adhikari","year":"2020","unstructured":"Adhikari SP, Meng S, Wu YJ et al (2020) Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty 9(1):29","journal-title":"Infect Dis Poverty"},{"issue":"7809","key":"19_CR2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","volume":"581","author":"R W\u00f6lfel","year":"2020","unstructured":"W\u00f6lfel R, Corman VM, Guggemos W et al (2020) Virological assessment of hospitalized patients with COVID-2019. Nature 581(7809):465\u2013469","journal-title":"Nature"},{"issue":"10229","key":"19_CR3","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","volume":"395","author":"F Zhou","year":"2020","unstructured":"Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395(10229):1054\u20131062","journal-title":"Lancet"},{"issue":"6","key":"19_CR4","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","volume":"46","author":"L Gattinoni","year":"2020","unstructured":"Gattinoni L, Chiumello D, Caironi P et al (2020) COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med 46(6):1099\u20131102","journal-title":"Intensive Care Med"},{"issue":"1","key":"19_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2466-14-194","volume":"14","author":"S Aliberti","year":"2014","unstructured":"Aliberti S, Messinesi G, Gamberini S et al (2014) Non-invasive mechanical ventilation in patients with diffuse interstitial lung diseases. BMC Pulm Med 14(1):1\u20138","journal-title":"BMC Pulm Med"},{"key":"19_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7527953","volume":"2020","author":"S Cicco","year":"2020","unstructured":"Cicco S, Cicco G, Vacca A et al (2020) Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): two potential targets for COVID-19 treatment. Mediat Inflamm 2020:1\u201325. https:\/\/doi.org\/10.1155\/2020\/7527953","journal-title":"Mediat Inflamm"},{"issue":"1","key":"19_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","volume":"249","author":"D Tang","year":"2012","unstructured":"Tang D, Kang R, Lotze MT et al (2012) PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev 249(1):158\u2013175","journal-title":"Immunol Rev"},{"issue":"4","key":"19_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/cdd.2017.1","volume":"24","author":"X Liu","year":"2017","unstructured":"Liu X, Cao H, Li J et al (2017) Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell Death Differ 24(4):683\u2013693","journal-title":"Cell Death Differ"},{"issue":"15","key":"19_CR9","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","volume":"19","author":"R Kang","year":"2013","unstructured":"Kang R, Zhang Q, Zeh HJ, Tang D et al (2013) HMGB1 in cancer: good, bad, or both? Clin Cancer Res 19(15):4046\u20134057","journal-title":"Clin Cancer Res"},{"key":"19_CR10","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.phrs.2016.06.031","volume":"111","author":"E Venereau","year":"2016","unstructured":"Venereau E, De Leo F, Bianchi ME et al (2016) HMGB1 as biomarker and drug target. Pharmacol Res 111:534\u2013544","journal-title":"Pharmacol Res"},{"issue":"1","key":"19_CR11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jhep.2015.02.009","volume":"63","author":"W Liu","year":"2015","unstructured":"Liu W, Yan ST et al (2015) Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9. J Hepatol 63(1):114\u2013121","journal-title":"J Hepatol"},{"issue":"18","key":"19_CR12","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1002\/j.1460-2075.1996.tb00878.x","volume":"15","author":"V Zappavigna","year":"1996","unstructured":"Zappavigna V, Falciola L, Bianchi ME et al (1996) HMGB1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. EMBO J 15(18):4981\u20134991","journal-title":"EMBO J"},{"key":"19_CR13","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.smim.2018.02.011","volume":"38","author":"U Andersson","year":"2018","unstructured":"Andersson U, Yang H, Harris H (2018) High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells. Semin Immunol 38:40\u201348","journal-title":"Semin Immunol"},{"issue":"7269","key":"19_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature08512","volume":"462","author":"H Yanai","year":"2009","unstructured":"Yanai H, Ban T, Wang Z et al (2009) HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462(7269):99\u2013103","journal-title":"Nature"},{"issue":"1","key":"19_CR15","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.bbrc.2005.08.020","volume":"338","author":"G Kikuchi","year":"2005","unstructured":"Kikuchi G, Yoshida T, Noguchi M (2005) Heme oxygenase and heme degradation. Biochem Biophys Res Commun 338(1):558\u2013567","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"19_CR16","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1152\/physrev.00011.2005","volume":"86","author":"SW Ryter","year":"2006","unstructured":"Ryter SW, Alam J, Choi AM (2006) Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86(2):583\u2013650. https:\/\/doi.org\/10.1152\/physrev.00011.2005. PMID 16601269","journal-title":"Physiol Rev"},{"key":"19_CR17","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.arcmed.2017.10.007","volume":"48","author":"EJ Park","year":"2017","unstructured":"Park EJ, Kim YM, Chang KC (2017) Hemin reduces HMGB1 release by UVB in an AMPK\/HO-1-dependent pathway in human keratinocytes HaCaT cells. Arch Med Res 48:423\u2013431","journal-title":"Arch Med Res"},{"key":"19_CR18","doi-asserted-by":"publisher","first-page":"212","DOI":"10.4049\/jimmunol.1601414","volume":"199","author":"M Kalergis Gonz\u00e1lez","year":"2017","unstructured":"Kalergis Gonz\u00e1lez M, Riedel CA, Bueno SM (2017) Pathogenesis during infection respiratory syncytial virus replication and heme oxygenase-1 modulates human. J Immunol 199:212\u2013223. https:\/\/doi.org\/10.4049\/jimmunol.1601414","journal-title":"J Immunol"},{"key":"19_CR19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ajpath.2016.11.011","volume":"187","author":"JA Espinoza","year":"2017","unstructured":"Espinoza JA, Gonz\u00e1lez PA, Kalergis AM (2017) Modulation of an-tiviral immunity by heme oxygenase-1. Am J Pathol 187:487\u2013493","journal-title":"Am J Pathol"},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s12192-020-01126-9","volume":"25","author":"PL Hooper","year":"2020","unstructured":"Hooper PL (2020) COVID-19 and heme oxygenase: novel insight into the disease and potential therapies. Cell Stress Chaperones 25:707\u2013710","journal-title":"Cell Stress Chaperones"},{"key":"19_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.freeradbiomed.2020.10.016","volume":"161","author":"D Singh","year":"2020","unstructured":"Singh D, Wasan H, Reet KH (2020) Heme oxygenase-1 modulation: a potential therapeutic target for COVID-19 and associated complications. Free Radic Biol Med 161:263\u2013271","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"19_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3390\/antiox9060540","volume":"9","author":"FADTG Wagener","year":"2020","unstructured":"Wagener FADTG, Pickkers P, Peterson SJ et al (2020) Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections. Antioxidants 9(6):540. https:\/\/doi.org\/10.3390\/antiox9060540","journal-title":"Antioxidants"},{"key":"19_CR23","doi-asserted-by":"publisher","first-page":"110242","DOI":"10.1016\/j.mehy.2020.110242","volume":"144","author":"M Rossi","year":"2020","unstructured":"Rossi M, Piagnerelli M, Van Meerhaeghe A et al (2020) Heme oxygenase-1 (HO-1) cytoprotective pathway: a potential treatment strategy against coronavirus disease 2019 (COVID-19)-induced cytokine storm syndrome. Med Hypotheses 144:110242. https:\/\/doi.org\/10.1016\/j.mehy.2020.110242. Epub 3 Sep 2020","journal-title":"Med Hypotheses"},{"key":"19_CR24","doi-asserted-by":"publisher","unstructured":"Elfeky M, Kaede R, Okamatsu-Ogura Y et al Adiponectin inhibits LPS-induced HMGB1 release through an AMP kinase and heme oxygenase-1-dependent pathway in RAW 264 macrophage cells. Mediators Inflamm 2016, Article ID 5701959, 9 pages. https:\/\/doi.org\/10.1155\/2016\/5701959","DOI":"10.1155\/2016\/5701959"},{"key":"19_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jss.2019.10.011","volume":"247","author":"M Luo","year":"2020","unstructured":"Luo M, Hong XQ, Zhu H et al (2020) The HO-1 signal prevents HMGB1-mediated activation of NLRP3 inflammasomes in lipopolysaccharide-induced acute lung injury in vitro. J Surg Res 247:335\u2013343. https:\/\/doi.org\/10.1016\/j.jss.2019.10.011. Epub 22 Nov 2019","journal-title":"J Surg Res"},{"key":"19_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.intimp.2019.01.022","volume":"69","author":"Y Yu","year":"2019","unstructured":"Yu Y, Yang Y, Yang M et al (2019) Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2\/HO-1-dependent pathway. Int Immunopharmacol 69:11\u201318. https:\/\/doi.org\/10.1016\/j.intimp.2019.01.022. Epub 18 Jan 2019","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"19_CR27","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.intimp.2008.01.026","volume":"8","author":"Q Gong","year":"2008","unstructured":"Gong Q, Yin H, Fang M et al (2008) Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol 8(6):792\u2013798. https:\/\/doi.org\/10.1016\/j.intimp.2008.01.026. Epub 7 Mar 2008","journal-title":"Int Immunopharmacol"},{"key":"19_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41419-021-03428-x","volume":"12","author":"T Deng","year":"2021","unstructured":"Deng T, Tang C, Zhang G et al (2021) DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities. Cell Death Dis 12:129. https:\/\/doi.org\/10.1038\/s41419-021-03428-x","journal-title":"Cell Death Dis"},{"key":"19_CR29","doi-asserted-by":"publisher","first-page":"106504","DOI":"10.1016\/j.intimp.2020.106504","volume":"84","author":"A-P Yang","year":"2020","unstructured":"Yang A-P, Liu J-P, Tao W-Q et al (2020) The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol 84:106504. https:\/\/doi.org\/10.1016\/j.intimp.2020.106504. Epub 13 Apr 2020","journal-title":"Int Immunopharmacol"},{"key":"19_CR30","doi-asserted-by":"publisher","unstructured":"Karakike E, Giamarellos-Bourboulis EJ Macrophage activation-like syndrome: a distinct entity leading to early death in sepsis. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.00055","DOI":"10.3389\/fimmu.2019.00055"},{"key":"19_CR31","doi-asserted-by":"publisher","first-page":"560381","DOI":"10.3389\/fimmu.2020.560381","volume":"11","author":"J G\u00f3mez-Rial","year":"2020","unstructured":"G\u00f3mez-Rial J, Curr\u00e1s-Tuala MJ, Rivero-Calle I (2020) Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology. Front Immunol 11:560381. https:\/\/doi.org\/10.3389\/fimmu.2020.560381. eCollection 2020","journal-title":"Front Immunol"}],"container-title":["Advances in Experimental Medicine and Biology","Oxygen Transport to Tissue XLIII"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-14190-4_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T16:12:52Z","timestamp":1691165572000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-14190-4_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031141898","9783031141904"],"references-count":31,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-14190-4_19","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"18 December 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}