{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T01:08:30Z","timestamp":1784509710914,"version":"3.55.0"},"publisher-location":"Cham","reference-count":156,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031261626","type":"print"},{"value":"9783031261633","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-3-031-26163-3_1","type":"book-chapter","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:03:29Z","timestamp":1682323409000},"page":"3-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases"],"prefix":"10.1007","author":[{"given":"Katina","family":"Schinnerling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Penny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Melo-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1\u20139. https:\/\/doi.org\/10.1038\/s12276-018-0126-x","journal-title":"Exp Mol Med"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1152\/physrev.00004.2016","volume":"96","author":"CM Evans","year":"2016","unstructured":"Evans CM, Fingerlin TE, Schwarz MI et al (2016) Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways. Physiol Rev 96:1567\u20131591. https:\/\/doi.org\/10.1152\/physrev.00004.2016","journal-title":"Physiol Rev"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"e185630","DOI":"10.1001\/jamanetworkopen.2018.5630","volume":"2","author":"RS Gupta","year":"2019","unstructured":"Gupta RS, Warren CM, Smith BM et al (2019) Prevalence and severity of food allergies among US adults. JAMA Netw Open 2:e185630\u2013e185630. https:\/\/doi.org\/10.1001\/jamanetworkopen.2018.5630","journal-title":"JAMA Netw Open"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.jaci.2017.04.006","volume":"140","author":"WW Acker","year":"2017","unstructured":"Acker WW, Plasek JM, Blumenthal KG et al (2017) Prevalence of food allergies and intolerances documented in electronic health records. J Allergy Clin Immunol 140:1587\u20131591.e1. https:\/\/doi.org\/10.1016\/j.jaci.2017.04.006","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nri.2016.111","volume":"16","author":"W Yu","year":"2016","unstructured":"Yu W, Freeland DMH, Nadeau KC (2016) Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol 16:751\u2013765. https:\/\/doi.org\/10.1038\/nri.2016.111","journal-title":"Nat Rev Immunol"},{"key":"1_CR6","doi-asserted-by":"publisher","unstructured":"Mathias CB, Hobson SA, Garcia-Lloret M et al (2011) IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol 127:795\u2013805.e8056. https:\/\/doi.org\/10.1016\/j.jaci.2010.11.009","DOI":"10.1016\/j.jaci.2010.11.009"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jaci.2008.10.001","volume":"123","author":"EB Brandt","year":"2009","unstructured":"Brandt EB, Munitz A, Orekov T et al (2009) Targeting IL-4\/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol 123:53\u201358. https:\/\/doi.org\/10.1016\/j.jaci.2008.10.001","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/mi.2012.112","volume":"6","author":"OT Burton","year":"2013","unstructured":"Burton OT, Darling AR, Zhou JS et al (2013) Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol 6:740\u2013750. https:\/\/doi.org\/10.1038\/mi.2012.112","journal-title":"Mucosal Immunol"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/j.ajpath.2011.12.036","volume":"180","author":"R Ahrens","year":"2012","unstructured":"Ahrens R, Osterfeld H, Wu D et al (2012) Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice. Am J Pathol 180:1535\u20131546. https:\/\/doi.org\/10.1016\/j.ajpath.2011.12.036","journal-title":"Am J Pathol"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1084\/jem.20071046","volume":"205","author":"EE Forbes","year":"2008","unstructured":"Forbes EE, Groschwitz K, Abonia JP et al (2008) IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med 205:897\u2013913. https:\/\/doi.org\/10.1084\/jem.20071046","journal-title":"J Exp Med"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.immuni.2015.08.020","volume":"43","author":"C-Y Chen","year":"2015","unstructured":"Chen C-Y, Lee J-B, Liu B et al (2015) Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy. Immunity 43:788\u2013802. https:\/\/doi.org\/10.1016\/j.immuni.2015.08.020","journal-title":"Immunity"},{"key":"1_CR12","doi-asserted-by":"publisher","unstructured":"Kashiwakura J-I, Ando T, Karasuyama H et al (2019) The basophil-IL-4-mast cell axis is required for food allergy. Allergy 74:1992\u20131996. https:\/\/doi.org\/10.1111\/all.13834","DOI":"10.1111\/all.13834"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.jaci.2013.06.008","volume":"132","author":"LL Reber","year":"2013","unstructured":"Reber LL, Marichal T, Mukai K et al (2013) Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol 132:881\u2013888.e11. https:\/\/doi.org\/10.1016\/j.jaci.2013.06.008","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41577-019-0194-8","volume":"19","author":"GF Sonnenberg","year":"2019","unstructured":"Sonnenberg GF, Hepworth MR (2019) Functional interactions between innate lymphoid cells and adaptive immunity. Nat Rev Immunol 19:599\u2013613","journal-title":"Nat Rev Immunol"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/cea.13075","volume":"48","author":"OT Burton","year":"2018","unstructured":"Burton OT, Medina Tamayo J, Stranks AJ et al (2018) IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy 48:288\u2013296. https:\/\/doi.org\/10.1111\/cea.13075","journal-title":"Clin Exp Allergy"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.jaci.2015.09.019","volume":"137","author":"J-B Lee","year":"2016","unstructured":"Lee J-B, Chen C-Y, Liu B et al (2016) IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. J Allergy Clin Immunol 137:1216\u20131225.e5. https:\/\/doi.org\/10.1016\/j.jaci.2015.09.019","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR17","doi-asserted-by":"publisher","unstructured":"Aguilera-Lizarraga J, Florens MV, Viola MF et al (2021) Local immune response to food antigens drives meal-induced abdominal pain. Nature 590:151\u2013156. https:\/\/doi.org\/10.1038\/s41586-020-03118-2","DOI":"10.1038\/s41586-020-03118-2"},{"key":"1_CR18","doi-asserted-by":"publisher","unstructured":"Jones MP, Walker MM, Ford AC, Talley NJ (2014) The overlap of atopy and functional gastrointestinal disorders among 23 471 patients in primary care. Aliment Pharmacol Ther 40:382\u2013391. https:\/\/doi.org\/10.1111\/apt.12846","DOI":"10.1111\/apt.12846"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S1081-1206(10)60404-8","volume":"100","author":"MC Tobin","year":"2008","unstructured":"Tobin MC, Moparty B, Farhadi A et al (2008) Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol 100:49\u201353. https:\/\/doi.org\/10.1016\/S1081-1206(10)60404-8","journal-title":"Ann Allergy Asthma Immunol"},{"key":"1_CR20","doi-asserted-by":"publisher","unstructured":"Spergel JM (2010) From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol 105:99\u2013106. https:\/\/doi.org\/10.1016\/j.anai.2009.10.002","DOI":"10.1016\/j.anai.2009.10.002"},{"key":"1_CR21","doi-asserted-by":"publisher","unstructured":"Caffarelli C, Cavagni G, Romanini E et al (2001) Duodenal IgE-positive cells and elimination diet responsiveness in children with atopic dermatitis. Ann Allergy Asthma Immunol 86:665\u2013670. https:\/\/doi.org\/10.1016\/S1081-1206(10)62296-X","DOI":"10.1016\/S1081-1206(10)62296-X"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.jaci.2011.01.031","volume":"127","author":"SJ Brown","year":"2011","unstructured":"Brown SJ, Asai Y, Cordell HJ et al (2011) Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 127:661\u2013667. https:\/\/doi.org\/10.1016\/j.jaci.2011.01.031","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.jaci.2014.08.011","volume":"134","author":"HA Brough","year":"2014","unstructured":"Brough HA, Simpson A, Makinson K et al (2014) Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol 134:867\u2013875.e1. https:\/\/doi.org\/10.1016\/j.jaci.2014.08.011","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jaci.2012.11.032","volume":"131","author":"LM Bartnikas","year":"2013","unstructured":"Bartnikas LM, Gurish MF, Burton OT et al (2013) Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol 131:451\u2013460.e606. https:\/\/doi.org\/10.1016\/j.jaci.2012.11.032","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jaci.2020.08.043","volume":"147","author":"S Tomar","year":"2021","unstructured":"Tomar S, Ganesan V, Sharma A et al (2021) IL-4-BATF signaling directly modulates IL-9 producing mucosal mast cell (MMC9) function in experimental food allergy. J Allergy Clin Immunol 147:280\u2013295. https:\/\/doi.org\/10.1016\/j.jaci.2020.08.043","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR26","doi-asserted-by":"publisher","unstructured":"Noti M, Kim BS, Siracusa MC et al (2014) Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin\u2013basophil axis. J Allergy Clin Immunol 133:1390\u20131399.e6. https:\/\/doi.org\/10.1016\/j.jaci.2014.01.021","DOI":"10.1016\/j.jaci.2014.01.021"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"5442","DOI":"10.1172\/JCI77798","volume":"124","author":"H Han","year":"2014","unstructured":"Han H, Thelen TD, Comeau MR, Ziegler SF (2014) Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest 124:5442\u20135452. https:\/\/doi.org\/10.1172\/JCI77798","journal-title":"J Clin Invest"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.jaci.2016.03.056","volume":"138","author":"C Galand","year":"2016","unstructured":"Galand C, Leyva-Castillo JM, Yoon J et al (2016) IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol 138:1356\u20131366. https:\/\/doi.org\/10.1016\/j.jaci.2016.03.056","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/mi.2017.61","volume":"11","author":"H Han","year":"2018","unstructured":"Han H, Roan F, Johnston LK et al (2018) IL-33 promotes gastrointestinal allergy in a TSLP-independent manner. Mucosal Immunol 11:394\u2013403. https:\/\/doi.org\/10.1038\/mi.2017.61","journal-title":"Mucosal Immunol"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.immuni.2019.03.023","volume":"50","author":"J-M Leyva-Castillo","year":"2019","unstructured":"Leyva-Castillo J-M, Galand C, Kam C et al (2019) Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion. Immunity 50:1262\u20131275.e4. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.023","journal-title":"Immunity"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.1172\/JCI75660","volume":"124","author":"L Tordesillas","year":"2014","unstructured":"Tordesillas L, Goswami R, Bened\u00e9 S et al (2014) Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J Clin Invest 124:4965\u20134975. https:\/\/doi.org\/10.1172\/JCI75660","journal-title":"J Clin Invest"},{"key":"1_CR32","doi-asserted-by":"publisher","unstructured":"Pazos-Castro D, Gonzalez-Klein Z, Montalvo AY et al (2022) NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model. Sci Rep 12:3329. https:\/\/doi.org\/10.1038\/s41598-022-07421-y","DOI":"10.1038\/s41598-022-07421-y"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jaci.2022.02.024","volume":"150","author":"JW Krempski","year":"2022","unstructured":"Krempski JW, Lama JK, Iijima K et al (2022) A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure. J Allergy Clin Immunol 150:425\u2013439.e3. https:\/\/doi.org\/10.1016\/j.jaci.2022.02.024","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR34","doi-asserted-by":"crossref","unstructured":"El Ansari YS, Kanagaratham C, Burton OT et al (2022) Allergen-specific IgA antibodies block IgE-mediated activation of mast cells and basophils. Front Immunol 13","DOI":"10.3389\/fimmu.2022.881655"},{"key":"1_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12016-018-8680-5","volume":"55","author":"L Tordesillas","year":"2018","unstructured":"Tordesillas L, Berin MC (2018) Mechanisms of oral tolerance. Clin Rev Allergy Immunol 55:107\u2013117. https:\/\/doi.org\/10.1007\/s12016-018-8680-5","journal-title":"Clin Rev Allergy Immunol"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jaci.2011.01.034","volume":"127","author":"RT Strait","year":"2011","unstructured":"Strait RT, Mahler A, Hogan S et al (2011) Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. J Allergy Clin Immunol 127:982\u2013989.e1. https:\/\/doi.org\/10.1016\/j.jaci.2011.01.034","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.immuni.2020.10.002","volume":"53","author":"JA Turner","year":"2020","unstructured":"Turner JA, Stephen-Victor E, Wang S et al (2020) Regulatory T cell-derived TGF-\u03b21 controls multiple checkpoints governing allergy and autoimmunity. Immunity 53:1202\u20131214.e6. https:\/\/doi.org\/10.1016\/j.immuni.2020.10.002","journal-title":"Immunity"},{"key":"1_CR38","doi-asserted-by":"publisher","unstructured":"Noval Rivas M, Burton OT, Wise P et al (2015) Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42:512\u2013523. https:\/\/doi.org\/10.1016\/j.immuni.2015.02.004","DOI":"10.1016\/j.immuni.2015.02.004"},{"key":"1_CR39","doi-asserted-by":"publisher","unstructured":"Abdel-Gadir A, Stephen-Victor E, Gerber GK et al (2019) Microbiota therapy acts via a regulatory T cell MyD88\/ROR\u03b3t pathway to suppress food allergy. Nat Med 25:1164\u20131174. https:\/\/doi.org\/10.1038\/s41591-019-0461-z","DOI":"10.1038\/s41591-019-0461-z"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"13145","DOI":"10.1073\/pnas.1412008111","volume":"111","author":"AT Stefka","year":"2014","unstructured":"Stefka AT, Feehley T, Tripathi P et al (2014) Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci USA 111:13145\u201313150. https:\/\/doi.org\/10.1073\/pnas.1412008111","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.851993","volume":"3","author":"KG Stark","year":"2022","unstructured":"Stark KG, Falkowski NR, Brown CA et al (2022) Contribution of the microbiome, environment, and genetics to mucosal type 2 immunity and anaphylaxis in a murine food allergy model. Front Allergy 3:851993. https:\/\/doi.org\/10.3389\/falgy.2022.851993","journal-title":"Front Allergy"},{"key":"1_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.599637","volume":"11","author":"JM Smeekens","year":"2021","unstructured":"Smeekens JM, Johnson-Weaver BT, Hinton AL et al (2021) Fecal IgA, antigen absorption, and gut microbiome composition are associated with food antigen sensitization in genetically susceptible mice. Front Immunol 11:599637. https:\/\/doi.org\/10.3389\/fimmu.2020.599637","journal-title":"Front Immunol"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.3390\/nu13103315","volume":"13","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Cheng L, Wang J et al (2021) Antibiotic-induced gut microbiota dysbiosis damages the intestinal barrier, increasing food allergy in adult mice. Nutrients 13:3315. https:\/\/doi.org\/10.3390\/nu13103315","journal-title":"Nutrients"},{"key":"1_CR44","doi-asserted-by":"publisher","unstructured":"Hussain M, Bonilla-Rosso G, Kwong Chung CKC et al (2019) High dietary fat intake induces a microbiota signature that promotes food allergy. J Allergy Clin Immunol 144:157\u2013170.e8. https:\/\/doi.org\/10.1016\/j.jaci.2019.01.043","DOI":"10.1016\/j.jaci.2019.01.043"},{"key":"1_CR45","doi-asserted-by":"crossref","unstructured":"Mennini M, Arasi S, Artesani MC, Fiocchi AG (2021) Probiotics in food allergy. Curr Opin Allergy Clin Immunol 21","DOI":"10.1097\/ACI.0000000000000745"},{"key":"1_CR46","doi-asserted-by":"publisher","unstructured":"Tan-Lim CSC, Esteban-Ipac NAR (2018) Probiotics as treatment for food allergies among pediatric patients: a meta-analysis. World Allergy Organ J 11:25. https:\/\/doi.org\/10.1186\/s40413-018-0204-5","DOI":"10.1186\/s40413-018-0204-5"},{"key":"1_CR47","doi-asserted-by":"publisher","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","volume":"2","author":"A Kaul","year":"2016","unstructured":"Kaul A, Gordon C, Crow MK et al (2016) Systemic lupus erythematosus. Nat Rev Dis Primers 2:16039. https:\/\/doi.org\/10.1038\/nrdp.2016.39","journal-title":"Nat Rev Dis Primers"},{"key":"1_CR48","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13075-021-02614-8","volume":"23","author":"M Kudsi","year":"2021","unstructured":"Kudsi M, Nahas LD, Alsawah R, Hamsho A, Omar A (2021) The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients. Arthritis Res Ther 23(1):229. https:\/\/doi.org\/10.1186\/s13075-021-02614-8. PMID: 34479636; PMCID: PMC8414847","journal-title":"Arthritis Res Ther"},{"key":"1_CR49","doi-asserted-by":"publisher","unstructured":"L\u00f3pez-Labady J, Villarroel-Dorrego M, Gonz\u00e1lez N et al (2007) Oral manifestations of systemic and cutaneous lupus erythematosus in a Venezuelan population. J Oral Pathol Med 36:524\u2013527. https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00569.x","DOI":"10.1111\/j.1600-0714.2007.00569.x"},{"key":"1_CR50","doi-asserted-by":"publisher","unstructured":"Meyer U, Kleinheinz J, Handschel J et al (2000) Oral findings in three different groups of immunocompromised patients. J Oral Pathol Med 29:153\u2013158. https:\/\/doi.org\/10.1034\/j.1600-0714.2000.290402.x","DOI":"10.1034\/j.1600-0714.2000.290402.x"},{"key":"1_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919792","volume":"13","author":"L Ma","year":"2022","unstructured":"Ma L, Morel L (2022) Loss of gut barrier integrity in lupus. Front Immunol 13:919792. https:\/\/doi.org\/10.3389\/fimmu.2022.919792","journal-title":"Front Immunol"},{"issue":"4","key":"1_CR52","doi-asserted-by":"publisher","first-page":"436","DOI":"10.2340\/00015555-1103","volume":"91","author":"MMS Nico","year":"2011","unstructured":"Nico MMS, Romiti R, Louren\u00e7o SV (2011) Oral lesions in four cases of subacute cutaneous lupus erythematosus. Acta Derm Venereol 91(4):436\u2013439","journal-title":"Acta Derm Venereol"},{"key":"1_CR53","doi-asserted-by":"publisher","unstructured":"Hsieh R, da Costa Marques ERM, Silva R, Hsieh R (2020) Oral mucosal manifestation of lupus erythematosus: a short review. Dental Oral Biol Craniofac Res 1\u20134. https:\/\/doi.org\/10.31487\/j.dobcr.2020.02.09","DOI":"10.31487\/j.dobcr.2020.02.09"},{"key":"1_CR54","doi-asserted-by":"publisher","unstructured":"Chen B, Jia X, Xu J et al (2021) An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus. Arthritis Rheumatol 73:232\u2013243. https:\/\/doi.org\/10.1002\/art.41511","DOI":"10.1002\/art.41511"},{"key":"1_CR55","doi-asserted-by":"publisher","unstructured":"Zegarra-Ruiz DF, El Beidaq A, I\u00f1iguez AJ et al (2019) A diet-sensitive commensal lactobacillus strain mediates TLR7-dependent systemic autoimmunity. Cell Host Microbe 25:113\u2013127.e6. https:\/\/doi.org\/10.1016\/j.chom.2018.11.009","DOI":"10.1016\/j.chom.2018.11.009"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3748\/wjg.v24.i1.5","volume":"24","author":"Z-H Shen","year":"2018","unstructured":"Shen Z-H, Zhu C-X, Quan Y-S et al (2018) Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation. World J Gastroenterol 24:5\u201314. https:\/\/doi.org\/10.3748\/wjg.v24.i1.5","journal-title":"World J Gastroenterol"},{"key":"1_CR57","doi-asserted-by":"publisher","unstructured":"Lobionda S, Sittipo P, Kwon HY, Lee YK (2019) The role of gut microbiota in intestinal inflammation with respect to diet and extrinsic stressors. Microorganisms 7. https:\/\/doi.org\/10.3390\/microorganisms7080271","DOI":"10.3390\/microorganisms7080271"},{"key":"1_CR58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s40168-017-0300-8","volume":"5","author":"Q Mu","year":"2017","unstructured":"Mu Q, Zhang H, Liao X et al (2017) Control of lupus nephritis by changes of gut microbiota. Microbiome 5:73. https:\/\/doi.org\/10.1186\/s40168-017-0300-8","journal-title":"Microbiome"},{"key":"1_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2019.04.002","volume":"340","author":"BA Malynn","year":"2019","unstructured":"Malynn BA, Ma A (2019) A20: a multifunctional tool for regulating immunity and preventing disease. Cell Immunol 340:103914. https:\/\/doi.org\/10.1016\/j.cellimm.2019.04.002","journal-title":"Cell Immunol"},{"key":"1_CR60","doi-asserted-by":"publisher","unstructured":"Al-Sadi R, Boivin M, Ma T (2009) Mechanism of cytokine modulation of epithelial tight junction barrier. Front Biosci (Landmark Ed) 14:2765\u20132778. https:\/\/doi.org\/10.2741\/3413","DOI":"10.2741\/3413"},{"key":"1_CR61","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13075-019-1878-y","volume":"21","author":"V Oke","year":"2019","unstructured":"Oke V, Gunnarsson I, Dorschner J et al (2019) High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus. Arthritis Res Ther 21:107. https:\/\/doi.org\/10.1186\/s13075-019-1878-y","journal-title":"Arthritis Res Ther"},{"key":"1_CR62","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature05698","volume":"446","author":"A Nenci","year":"2007","unstructured":"Nenci A, Becker C, Wullaert A et al (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446:557\u2013561. https:\/\/doi.org\/10.1038\/nature05698","journal-title":"Nature"},{"key":"1_CR63","doi-asserted-by":"publisher","first-page":"e02288","DOI":"10.1128\/AEM.02288-17","volume":"84","author":"XM Luo","year":"2018","unstructured":"Luo XM, Edwards MR, Mu Q et al (2018) Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus. Appl Environ Microbiol 84:e02288\u2013e02317. https:\/\/doi.org\/10.1128\/AEM.02288-17","journal-title":"Appl Environ Microbiol"},{"key":"1_CR64","doi-asserted-by":"publisher","unstructured":"Hevia A, Milani C, L\u00f3pez P et al (2014) Intestinal dysbiosis associated with systemic lupus erythematosus. mBio 5:e01548. https:\/\/doi.org\/10.1128\/mBio.01548-14","DOI":"10.1128\/mBio.01548-14"},{"key":"1_CR65","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1042\/CS20180841","volume":"133","author":"Y Li","year":"2019","unstructured":"Li Y, Wang H-F, Li X et al (2019) Disordered intestinal microbes are associated with the activity of systemic lupus erythematosus. Clin Sci 133:821\u2013838. https:\/\/doi.org\/10.1042\/CS20180841","journal-title":"Clin Sci"},{"key":"1_CR66","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13099-016-0146-9","volume":"8","author":"Z He","year":"2016","unstructured":"He Z, Shao T, Li H et al (2016) Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus. Gut Pathog 8:64. https:\/\/doi.org\/10.1186\/s13099-016-0146-9","journal-title":"Gut Pathog"},{"key":"1_CR67","doi-asserted-by":"crossref","unstructured":"Liu F, Ren T, Li X et al (2021) Distinct microbiomes of gut and saliva in patients with systemic lupus erythematous and clinical associations. Front Immunol 12","DOI":"10.3389\/fimmu.2021.626217"},{"key":"1_CR68","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1136\/annrheumdis-2018-214856","volume":"78","author":"D Azzouz","year":"2019","unstructured":"Azzouz D, Omarbekova A, Heguy A et al (2019) Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann Rheum Dis 78:947\u2013956. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214856","journal-title":"Ann Rheum Dis"},{"key":"1_CR69","doi-asserted-by":"publisher","unstructured":"Shirakashi M, Maruya M, Hirota K et al (2022) Effect of impaired T cell receptor signaling on the gut microbiota in a mouse model of systemic autoimmunity. Arthritis Rheumatol 74:641\u2013653. https:\/\/doi.org\/10.1002\/art.42016","DOI":"10.1002\/art.42016"},{"key":"1_CR70","doi-asserted-by":"publisher","first-page":"7551","DOI":"10.1128\/AEM.02676-14","volume":"80","author":"H Zhang","year":"2014","unstructured":"Zhang H, Liao X, Sparks JB, Luo XM (2014) Dynamics of gut microbiota in autoimmune lupus. Appl Environ Microbiol 80:7551\u20137560. https:\/\/doi.org\/10.1128\/AEM.02676-14","journal-title":"Appl Environ Microbiol"},{"key":"1_CR71","doi-asserted-by":"publisher","first-page":"13675","DOI":"10.1038\/s41598-017-14223-0","volume":"7","author":"Q Mu","year":"2017","unstructured":"Mu Q, Tavella VJ, Kirby JL et al (2017) Antibiotics ameliorate lupus-like symptoms in mice. Sci Rep 7:13675. https:\/\/doi.org\/10.1038\/s41598-017-14223-0","journal-title":"Sci Rep"},{"key":"1_CR72","doi-asserted-by":"publisher","unstructured":"Manfredo Vieira S, Hiltensperger M, Kumar V et al (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359:1156\u20131161. https:\/\/doi.org\/10.1126\/science.aar7201","DOI":"10.1126\/science.aar7201"},{"key":"1_CR73","doi-asserted-by":"crossref","unstructured":"Shi L, Zhang Z, Yu AM et al (2014) The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs. PLoS ONE 9:e93846","DOI":"10.1371\/journal.pone.0093846"},{"key":"1_CR74","doi-asserted-by":"publisher","unstructured":"Ogunrinde E, Zhou Z, Luo Z et al (2019) A link between plasma microbial translocation, microbiome, and autoantibody development in first-degree relatives of systemic lupus erythematosus patients. Arthritis Rheumatol 71:1858\u20131868. https:\/\/doi.org\/10.1002\/art.40935","DOI":"10.1002\/art.40935"},{"key":"1_CR75","doi-asserted-by":"publisher","unstructured":"Issara-Amphorn J, Surawut S, Worasilchai N et al (2018) The synergy of endotoxin and (1\u21923)-\u03b2-D-glucan, from gut translocation, worsens sepsis severity in a lupus model of Fc gamma receptor IIb-deficient mice. J Innate Immun 10:189\u2013201. https:\/\/doi.org\/10.1159\/000486321","DOI":"10.1159\/000486321"},{"key":"1_CR76","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805\u2013820. https:\/\/doi.org\/10.1016\/j.cell.2010.01.022","journal-title":"Cell"},{"key":"1_CR77","doi-asserted-by":"publisher","unstructured":"Thim-uam A, Surawut S, Issara-Amphorn J et al (2020) Leaky-gut enhanced lupus progression in the Fc gamma receptor-IIb deficient and pristane-induced mouse models of lupus. Sci Rep 10:777. https:\/\/doi.org\/10.1038\/s41598-019-57275-0","DOI":"10.1038\/s41598-019-57275-0"},{"key":"1_CR78","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature24628","volume":"551","author":"N Wilck","year":"2017","unstructured":"Wilck N, Matus MG, Kearney SM et al (2017) Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551:585\u2013589. https:\/\/doi.org\/10.1038\/nature24628","journal-title":"Nature"},{"key":"1_CR79","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41392-020-0139-5","volume":"5","author":"ZX Xiao","year":"2020","unstructured":"Xiao ZX, Hu X, Zhang X et al (2020) High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways. Signal Transduct Target Ther 5:34. https:\/\/doi.org\/10.1038\/s41392-020-0139-5","journal-title":"Signal Transduct Target Ther"},{"key":"1_CR80","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/ibd.20933","volume":"15","author":"JP Gisbert","year":"2009","unstructured":"Gisbert JP, Bermejo F, P\u00e9rez-Calle J-L et al (2009) Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse. Inflamm Bowel Dis 15:1190\u20131198. https:\/\/doi.org\/10.1002\/ibd.20933","journal-title":"Inflamm Bowel Dis"},{"key":"1_CR81","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1365-2249.1994.tb06222.x","volume":"96","author":"WA Nockher","year":"1994","unstructured":"Nockher WA, Wigand R, Schoeppe W, Scherberich JE (1994) Elevated levels of soluble CD 14 in serum of patients with systemic lupus erythematosus. Clin Exp Immunol 96:15\u201319. https:\/\/doi.org\/10.1111\/j.1365-2249.1994.tb06222.x","journal-title":"Clin Exp Immunol"},{"key":"1_CR82","doi-asserted-by":"publisher","unstructured":"Beeram SR, Zhang C, Suh K et al (2021) Characterization of drug binding with alpha1-acid glycoprotein in clinical samples using ultrafast affinity extraction. J Chromatogr A 1649:462240. https:\/\/doi.org\/10.1016\/j.chroma.2021.462240","DOI":"10.1016\/j.chroma.2021.462240"},{"key":"1_CR83","doi-asserted-by":"publisher","unstructured":"Mackiewicz A, Marcinkowska-Pieta R, Ballou S et al (1987) Microheterogeneity of alpha1-acid glycoprotein in the detection of intercurrent infection in systemic lupus erythematosus. Arthritis Rheum 30:513\u2013518. https:\/\/doi.org\/10.1002\/art.1780300505","DOI":"10.1002\/art.1780300505"},{"key":"1_CR84","doi-asserted-by":"publisher","unstructured":"Rezvaninejad R, Dadmehr M, Rezvaninejad R (2021) Prevalence of oral manifestations in systemic lupus erythematosus patients referred to Shahid Mohammadi Hospital in 2018\u20132019. Jundishapur J Health Sci 13:e116144. https:\/\/doi.org\/10.5812\/jjhs.116144","DOI":"10.5812\/jjhs.116144"},{"key":"1_CR85","doi-asserted-by":"crossref","unstructured":"Aurlene N, Manipal S, Prabu D, Rajmohan (2020) Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu. J Fam Med Prim Care 9","DOI":"10.4103\/jfmpc.jfmpc_1263_19"},{"key":"1_CR86","doi-asserted-by":"publisher","unstructured":"Terui H, Yamasaki K, Wada-Irimada M et al (2022) Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23\/IL-17 axis. Sci Immunol 7:eabm9811. https:\/\/doi.org\/10.1126\/sciimmunol.abm9811","DOI":"10.1126\/sciimmunol.abm9811"},{"key":"1_CR87","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.jid.2019.11.016","volume":"140","author":"S Sirobhushanam","year":"2020","unstructured":"Sirobhushanam S, Parsa N, Reed TJ et al (2020) Staphylococcus aureus colonization is increased on lupus skin lesions and is promoted by IFN-mediated barrier disruption. J Investig Dermatol 140:1066\u20131074.e4. https:\/\/doi.org\/10.1016\/j.jid.2019.11.016","journal-title":"J Investig Dermatol"},{"key":"1_CR88","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis. Lancet 388:2023\u20132038. https:\/\/doi.org\/10.1016\/S0140-6736(16)30173-8","journal-title":"Lancet"},{"key":"1_CR89","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1741-7015-7-12","volume":"7","author":"RF van Vollenhoven","year":"2009","unstructured":"van Vollenhoven RF (2009) Sex differences in rheumatoid arthritis: more than meets the eye. BMC Med 7:12. https:\/\/doi.org\/10.1186\/1741-7015-7-12","journal-title":"BMC Med"},{"key":"1_CR90","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3899\/jrheum.200367","volume":"48","author":"KB Almutairi","year":"2021","unstructured":"Almutairi KB, Nossent JC, Preen DB et al (2021) The prevalence of rheumatoid arthritis: a systematic review of population-based studies. J Rheumatol 48:669. https:\/\/doi.org\/10.3899\/jrheum.200367","journal-title":"J Rheumatol"},{"key":"1_CR91","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","volume":"4","author":"JS Smolen","year":"2018","unstructured":"Smolen JS, Aletaha D, Barton A et al (2018) Rheumatoid arthritis. Nat Rev Dis Primers 4:18001. https:\/\/doi.org\/10.1038\/nrdp.2018.1","journal-title":"Nat Rev Dis Primers"},{"key":"1_CR92","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/nri.2016.124","volume":"17","author":"V Malmstr\u00f6m","year":"2017","unstructured":"Malmstr\u00f6m V, Catrina AI, Klareskog L (2017) The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol 17:60\u201375. https:\/\/doi.org\/10.1038\/nri.2016.124","journal-title":"Nat Rev Immunol"},{"key":"1_CR93","doi-asserted-by":"publisher","unstructured":"Gregersen PK, Silver J, Winchester RJ (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205\u20131213. https:\/\/doi.org\/10.1002\/art.1780301102","DOI":"10.1002\/art.1780301102"},{"key":"1_CR94","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.171.2.538","volume":"171","author":"JA Hill","year":"2003","unstructured":"Hill JA, Southwood S, Sette A et al (2003) Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 171:538. https:\/\/doi.org\/10.4049\/jimmunol.171.2.538","journal-title":"J Immunol"},{"key":"1_CR95","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41584-018-0070-0","volume":"14","author":"VM Holers","year":"2018","unstructured":"Holers VM, Demoruelle MK, Kuhn KA et al (2018) Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nat Rev Rheumatol 14:542\u2013557. https:\/\/doi.org\/10.1038\/s41584-018-0070-0","journal-title":"Nat Rev Rheumatol"},{"key":"1_CR96","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1002\/art.39771","volume":"68","author":"JD Kinslow","year":"2016","unstructured":"Kinslow JD, Blum LK, Deane KD et al (2016) Elevated IgA plasmablast levels in subjects at risk of developing rheumatoid arthritis. Arthritis Rheumatol 68:2372\u20132383. https:\/\/doi.org\/10.1002\/art.39771","journal-title":"Arthritis Rheumatol"},{"key":"1_CR97","doi-asserted-by":"publisher","unstructured":"Rantap\u00e4\u00e4-Dahlqvist S, de Jong BAW, Berglin E et al (2003) Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 48:2741\u20132749. https:\/\/doi.org\/10.1002\/art.11223","DOI":"10.1002\/art.11223"},{"key":"1_CR98","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/rheumatology\/34.3.236","volume":"34","author":"C Jorgensen","year":"1995","unstructured":"Jorgensen C, Moynier M, Bologna C et al (1995) Rheumatoid factor associated with a secretory component in rheumatoid arthritis. Rheumatology 34:236\u2013240. https:\/\/doi.org\/10.1093\/rheumatology\/34.3.236","journal-title":"Rheumatology"},{"key":"1_CR99","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13075-016-1014-1","volume":"18","author":"K Roos","year":"2016","unstructured":"Roos K, Martinsson K, Ziegelasch M et al (2016) Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking. Arthritis Res Ther 18:119. https:\/\/doi.org\/10.1186\/s13075-016-1014-1","journal-title":"Arthritis Res Ther"},{"key":"1_CR100","doi-asserted-by":"publisher","unstructured":"Gaffen SL, Moutsopoulos NM (2020) Regulation of host\u2013microbe interactions at oral mucosal barriers by type 17 immunity. Sci Immunol 5:eaau4594. https:\/\/doi.org\/10.1126\/sciimmunol.aau4594","DOI":"10.1126\/sciimmunol.aau4594"},{"key":"1_CR101","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3390\/cells11071079","volume":"11","author":"D-Y Park","year":"2022","unstructured":"Park D-Y, Park JY, Lee D et al (2022) Leaky gum: the revisited origin of systemic diseases. Cells 11:1079. https:\/\/doi.org\/10.3390\/cells11071079","journal-title":"Cells"},{"key":"1_CR102","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1016\/j.cell.2021.05.013","volume":"184","author":"DW Williams","year":"2021","unstructured":"Williams DW, Greenwell-Wild T, Brenchley L et al (2021) Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell 184:4090\u20134104.e15. https:\/\/doi.org\/10.1016\/j.cell.2021.05.013","journal-title":"Cell"},{"key":"1_CR103","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C et al (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532\u20131535. https:\/\/doi.org\/10.1126\/science.1092385","journal-title":"Science"},{"key":"1_CR104","doi-asserted-by":"publisher","unstructured":"Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A et al (2013) NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med 5:178ra40\u2013178ra40. https:\/\/doi.org\/10.1126\/scitranslmed.3005580","DOI":"10.1126\/scitranslmed.3005580"},{"key":"1_CR105","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.immuni.2016.12.010","volume":"46","author":"N Dutzan","year":"2017","unstructured":"Dutzan N, Abusleme L, Bridgeman H et al (2017) On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity 46:133\u2013147. https:\/\/doi.org\/10.1016\/j.immuni.2016.12.010","journal-title":"Immunity"},{"key":"1_CR106","doi-asserted-by":"publisher","unstructured":"Dutzan N, Kajikawa T, Abusleme L et al (2018) A dysbiotic microbiome triggers T(H)17 cells to mediate oral mucosal immunopathology in mice and humans. Sci Transl Med 10:eaat0797. https:\/\/doi.org\/10.1126\/scitranslmed.aat0797","DOI":"10.1126\/scitranslmed.aat0797"},{"key":"1_CR107","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1002\/art.34539","volume":"64","author":"JU Scher","year":"2012","unstructured":"Scher JU, Ubeda C, Equinda M et al (2012) Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 64:3083\u20133094. https:\/\/doi.org\/10.1002\/art.34539","journal-title":"Arthritis Rheum"},{"key":"1_CR108","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1902\/jop.2009.080447","volume":"80","author":"P Ortiz","year":"2009","unstructured":"Ortiz P, Bissada NF, Palomo L et al (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80:535\u2013540. https:\/\/doi.org\/10.1902\/jop.2009.080447","journal-title":"J Periodontol"},{"key":"1_CR109","doi-asserted-by":"publisher","first-page":"8379","DOI":"10.1038\/s41598-019-44674-6","volume":"9","author":"JD Corr\u00eaa","year":"2019","unstructured":"Corr\u00eaa JD, Fernandes GR, Calderaro DC et al (2019) Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep 9:8379. https:\/\/doi.org\/10.1038\/s41598-019-44674-6","journal-title":"Sci Rep"},{"key":"1_CR110","doi-asserted-by":"publisher","unstructured":"Konig MF, Abusleme L, Reinholdt J et al (2016) Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med 8:369ra176. https:\/\/doi.org\/10.1126\/scitranslmed.aaj1921","DOI":"10.1126\/scitranslmed.aaj1921"},{"key":"1_CR111","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1002\/art.27552","volume":"62","author":"N Wegner","year":"2010","unstructured":"Wegner N, Wait R, Sroka A et al (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and \u03b1-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62:2662\u20132672. https:\/\/doi.org\/10.1002\/art.27552","journal-title":"Arthritis Rheum"},{"key":"1_CR112","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1002\/art.40485","volume":"70","author":"I Lopez-Oliva","year":"2018","unstructured":"Lopez-Oliva I, Paropkari AD, Saraswat S et al (2018) Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis. Arthritis Rheumatol 70:1008\u20131013. https:\/\/doi.org\/10.1002\/art.40485","journal-title":"Arthritis Rheumatol"},{"key":"1_CR113","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"J Potempa","year":"2017","unstructured":"Potempa J, Mydel P, Koziel J (2017) The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol 13:606\u2013620. https:\/\/doi.org\/10.1038\/nrrheum.2017.132","journal-title":"Nat Rev Rheumatol"},{"key":"1_CR114","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/annrheumdis-2020-216972","volume":"80","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, Do T, Mankia K et al (2021) Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis. Ann Rheum Dis 80:162. https:\/\/doi.org\/10.1136\/annrheumdis-2020-216972","journal-title":"Ann Rheum Dis"},{"key":"1_CR115","doi-asserted-by":"publisher","unstructured":"Volkov M, Dekkers J, Loos BG et al (2018) Comment on \u201cAggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis.\u201d Sci Transl Med 10:eaan8349. https:\/\/doi.org\/10.1126\/scitranslmed.aan8349","DOI":"10.1126\/scitranslmed.aan8349"},{"key":"1_CR116","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40168-016-0206-x","volume":"4","author":"JU Scher","year":"2016","unstructured":"Scher JU, Joshua V, Artacho A et al (2016) The lung microbiota in early rheumatoid arthritis and autoimmunity. Microbiome 4:60. https:\/\/doi.org\/10.1186\/s40168-016-0206-x","journal-title":"Microbiome"},{"key":"1_CR117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.804822","volume":"13","author":"N Sherina","year":"2022","unstructured":"Sherina N, de Vries C, Kharlamova N et al (2022) Antibodies to a citrullinated Porphyromonas gingivalis epitope are increased in early rheumatoid arthritis, and can be produced by gingival tissue B cells: implications for a bacterial origin in RA etiology. Front Immunol 13:804822. https:\/\/doi.org\/10.3389\/fimmu.2022.804822","journal-title":"Front Immunol"},{"key":"1_CR118","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1136\/annrheumdis-2019-216919","volume":"79","author":"M Jenning","year":"2020","unstructured":"Jenning M, Marklein B, Ytterberg J et al (2020) Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection\u2014a missing link for ACPA production. Ann Rheum Dis 79:1194. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216919","journal-title":"Ann Rheum Dis"},{"key":"1_CR119","doi-asserted-by":"publisher","unstructured":"Klareskog L, Stolt P, Lundberg K et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA\u2013DR (shared epitope)\u2013restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38\u201346. https:\/\/doi.org\/10.1002\/art.21575","DOI":"10.1002\/art.21575"},{"key":"1_CR120","doi-asserted-by":"publisher","unstructured":"Reynisdottir G, Karimi R, Joshua V et al (2014) Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol 66:31\u201339. https:\/\/doi.org\/10.1002\/art.38201","DOI":"10.1002\/art.38201"},{"key":"1_CR121","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1002\/art.38066","volume":"65","author":"VC Willis","year":"2013","unstructured":"Willis VC, Demoruelle MK, Derber LA et al (2013) Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease. Arthritis Rheum 65:2545\u20132554. https:\/\/doi.org\/10.1002\/art.38066","journal-title":"Arthritis Rheum"},{"key":"1_CR122","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/art.40401","volume":"70","author":"MK Demoruelle","year":"2018","unstructured":"Demoruelle MK, Bowers E, Lahey LJ et al (2018) Antibody responses to citrullinated and noncitrullinated antigens in the sputum of subjects with rheumatoid arthritis and subjects at risk for development of rheumatoid arthritis. Arthritis Rheumatol 70:516\u2013527. https:\/\/doi.org\/10.1002\/art.40401","journal-title":"Arthritis Rheumatol"},{"key":"1_CR123","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s40744-021-00362-4","volume":"8","author":"T Khan","year":"2021","unstructured":"Khan T, Jose RJ, Renzoni EA, Mouyis M (2021) A closer look at the role of anti-CCP antibodies in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease and bronchiectasis. Rheumatol Ther 8:1463\u20131475. https:\/\/doi.org\/10.1007\/s40744-021-00362-4","journal-title":"Rheumatol Ther"},{"key":"1_CR124","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11926-020-00960-1","volume":"22","author":"TM Wilson","year":"2020","unstructured":"Wilson TM, Trent B, Kuhn KA, Demoruelle MK (2020) Microbial influences of mucosal immunity in rheumatoid arthritis. Curr Rheumatol Rep 22:83. https:\/\/doi.org\/10.1007\/s11926-020-00960-1","journal-title":"Curr Rheumatol Rep"},{"key":"1_CR125","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12891-021-04985-0","volume":"23","author":"S Oka","year":"2022","unstructured":"Oka S, Higuchi T, Furukawa H et al (2022) Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis. BMC Musculoskelet Disord 23:46. https:\/\/doi.org\/10.1186\/s12891-021-04985-0","journal-title":"BMC Musculoskelet Disord"},{"key":"1_CR126","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1801562","volume":"379","author":"P-A Juge","year":"2018","unstructured":"Juge P-A, Lee JS, Ebstein E et al (2018) MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. N Engl J Med 379:2209\u20132219. https:\/\/doi.org\/10.1056\/NEJMoa1801562","journal-title":"N Engl J Med"},{"key":"1_CR127","doi-asserted-by":"publisher","first-page":"e0162341","DOI":"10.1371\/journal.pone.0162341","volume":"11","author":"M Bidkar","year":"2016","unstructured":"Bidkar M, Vassallo R, Luckey D et al (2016) Cigarette smoke induces immune responses to vimentin in both, arthritis-susceptible and -resistant humanized mice. PLoS ONE 11:e0162341\u2013e0162341. https:\/\/doi.org\/10.1371\/journal.pone.0162341","journal-title":"PLoS ONE"},{"key":"1_CR128","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/art.40066","volume":"69","author":"MK Demoruelle","year":"2017","unstructured":"Demoruelle MK, Harrall KK, Ho L et al (2017) Anti-citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients. Arthritis Rheumatol 69:1165\u20131175. https:\/\/doi.org\/10.1002\/art.40066","journal-title":"Arthritis Rheumatol"},{"key":"1_CR129","doi-asserted-by":"publisher","unstructured":"Carmona-Rivera C, Carlucci PM, Moore E et al (2017) Synovial fibroblast\u2013neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Sci Immunol 2:eaag3358. https:\/\/doi.org\/10.1126\/sciimmunol.aag3358","DOI":"10.1126\/sciimmunol.aag3358"},{"key":"1_CR130","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1136\/annrheumdis-2013-204912","volume":"74","author":"AJ Ytterberg","year":"2015","unstructured":"Ytterberg AJ, Joshua V, Reynisdottir G et al (2015) Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation. Ann Rheum Dis 74:1772. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204912","journal-title":"Ann Rheum Dis"},{"key":"1_CR131","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12967-019-1810-x","volume":"17","author":"X Huang","year":"2019","unstructured":"Huang X, Fan X, Ying J, Chen S (2019) Emerging trends and research foci in gastrointestinal microbiome. J Transl Med 17:67. https:\/\/doi.org\/10.1186\/s12967-019-1810-x","journal-title":"J Transl Med"},{"key":"1_CR132","doi-asserted-by":"publisher","unstructured":"Brandl C, Bucci L, Schett G, Zaiss MM (2021) Crossing the barriers: revisiting the gut feeling in rheumatoid arthritis. Eur J Immunol 51:798\u2013810. https:\/\/doi.org\/10.1002\/eji.202048876","DOI":"10.1002\/eji.202048876"},{"key":"1_CR133","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ni.3512","volume":"17","author":"L Campisi","year":"2016","unstructured":"Campisi L, Barbet G, Ding Y et al (2016) Apoptosis in response to microbial infection induces autoreactive TH17 cells. Nat Immunol 17:1084\u20131092. https:\/\/doi.org\/10.1038\/ni.3512","journal-title":"Nat Immunol"},{"key":"1_CR134","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.3389\/fimmu.2018.01270","volume":"9","author":"C Andrews","year":"2018","unstructured":"Andrews C, McLean MH, Durum SK (2018) Cytokine tuning of intestinal epithelial function. Front Immunol 9:1270. https:\/\/doi.org\/10.3389\/fimmu.2018.01270","journal-title":"Front Immunol"},{"key":"1_CR135","doi-asserted-by":"publisher","unstructured":"Bruewer M, Utech M, Ivanov AI et al (2005) Interferon-\u03b3 induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 19:923\u2013933. https:\/\/doi.org\/10.1096\/fj.04-3260com","DOI":"10.1096\/fj.04-3260com"},{"key":"1_CR136","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1152\/physrev.00003.2008","volume":"91","author":"A Fasano","year":"2011","unstructured":"Fasano A (2011) Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 91:151\u2013175. https:\/\/doi.org\/10.1152\/physrev.00003.2008","journal-title":"Physiol Rev"},{"key":"1_CR137","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3945\/jn.110.135657","volume":"141","author":"D Ulluwishewa","year":"2011","unstructured":"Ulluwishewa D, Anderson RC, McNabb WC et al (2011) Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr 141:769\u2013776. https:\/\/doi.org\/10.3945\/jn.110.135657","journal-title":"J Nutr"},{"key":"1_CR138","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","volume":"11","author":"N Tajik","year":"2020","unstructured":"Tajik N, Frech M, Schulz O et al (2020) Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun 11:1995. https:\/\/doi.org\/10.1038\/s41467-020-15831-7","journal-title":"Nat Commun"},{"key":"1_CR139","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.medj.2021.04.013","volume":"2","author":"DE Matei","year":"2021","unstructured":"Matei DE, Menon M, Alber DG et al (2021) Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease. Med (N Y) 2:864\u2013883.e9. https:\/\/doi.org\/10.1016\/j.medj.2021.04.013","journal-title":"Med (N Y)"},{"key":"1_CR140","doi-asserted-by":"publisher","unstructured":"Audo R, Sanchez P, Rivi\u00e8re B et al (2022) Rheumatoid arthritis is associated with increased gut permeability and bacterial translocation that are reversed by inflammation control. Rheumatology keac454. https:\/\/doi.org\/10.1093\/rheumatology\/keac454","DOI":"10.1093\/rheumatology\/keac454"},{"key":"1_CR141","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","volume":"8","author":"J Chen","year":"2016","unstructured":"Chen J, Wright K, Davis JM et al (2016) An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Genome Med 8:43. https:\/\/doi.org\/10.1186\/s13073-016-0299-7","journal-title":"Genome Med"},{"key":"1_CR142","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125191","volume":"4","author":"MB Flak","year":"2019","unstructured":"Flak MB, Colas RA, Mu\u00f1oz-Atienza E et al (2019) Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight 4:e125191. https:\/\/doi.org\/10.1172\/jci.insight.125191","journal-title":"JCI Insight"},{"key":"1_CR143","doi-asserted-by":"publisher","unstructured":"Cheng M, Zhao Y, Cui Y et al (2022) Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study. bioRxiv. https:\/\/doi.org\/10.1101\/2022.02.13.480248","DOI":"10.1101\/2022.02.13.480248"},{"key":"1_CR144","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.immuni.2016.03.013","volume":"44","author":"F Teng","year":"2016","unstructured":"Teng F, Klinger CN, Felix KM et al (2016) Gut microbiota drive autoimmune arthritis by promoting differentiation and migration of Peyer\u2019s patch T follicular helper cells. Immunity 44:875\u2013888. https:\/\/doi.org\/10.1016\/j.immuni.2016.03.013","journal-title":"Immunity"},{"key":"1_CR145","doi-asserted-by":"publisher","unstructured":"Engevik MA, Versalovic J (2017) Biochemical features of beneficial microbes: foundations for therapeutic microbiology. Microbiol Spectr 5. https:\/\/doi.org\/10.1128\/microbiolspec.BAD-0012-2016","DOI":"10.1128\/microbiolspec.BAD-0012-2016"},{"key":"1_CR146","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"KM Maslowski","year":"2009","unstructured":"Maslowski KM, Vieira AT, Ng A et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282\u20131286. https:\/\/doi.org\/10.1038\/nature08530","journal-title":"Nature"},{"key":"1_CR147","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","volume":"9","author":"S Lucas","year":"2018","unstructured":"Lucas S, Omata Y, Hofmann J et al (2018) Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun 9:55. https:\/\/doi.org\/10.1038\/s41467-017-02490-4","journal-title":"Nat Commun"},{"key":"1_CR148","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cmet.2020.03.003","volume":"31","author":"EC Rosser","year":"2020","unstructured":"Rosser EC, Piper CJM, Matei DE et al (2020) Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metab 31:837\u2013851.e10. https:\/\/doi.org\/10.1016\/j.cmet.2020.03.003","journal-title":"Cell Metab"},{"key":"1_CR149","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fmed.2018.00349","volume":"5","author":"CS Guerreiro","year":"2018","unstructured":"Guerreiro CS, Calado \u00c2, Sousa J, Fonseca JE (2018) Diet, microbiota, and gut permeability\u2014the unknown triad in rheumatoid arthritis. Front Med (Lausanne) 5:349. https:\/\/doi.org\/10.3389\/fmed.2018.00349","journal-title":"Front Med (Lausanne)"},{"key":"1_CR150","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","volume":"21","author":"X Zhang","year":"2015","unstructured":"Zhang X, Zhang D, Jia H et al (2015) The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med 21:895\u2013905. https:\/\/doi.org\/10.1038\/nm.3914","journal-title":"Nat Med"},{"key":"1_CR151","doi-asserted-by":"publisher","first-page":"e01202","DOI":"10.7554\/eLife.01202","volume":"2","author":"JU Scher","year":"2013","unstructured":"Scher JU, Sczesnak A, Longman RS et al (2013) Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2:e01202\u2013e01202. https:\/\/doi.org\/10.7554\/eLife.01202","journal-title":"eLife"},{"key":"1_CR152","doi-asserted-by":"publisher","unstructured":"Alpizar-Rodriguez D, Lesker TR, Gronow A et al (2019) Prevotella copri in individuals at risk for rheumatoid arthritis. Ann Rheum Dis 78:590\u2013593. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214514","DOI":"10.1136\/annrheumdis-2018-214514"},{"key":"1_CR153","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/art.40003","volume":"69","author":"A Pianta","year":"2017","unstructured":"Pianta A, Arvikar S, Strle K et al (2017) Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis. Arthritis Rheumatol 69:964\u2013975. https:\/\/doi.org\/10.1002\/art.40003","journal-title":"Arthritis Rheumatol"},{"key":"1_CR154","doi-asserted-by":"publisher","unstructured":"Maeda Y, Kurakawa T, Umemoto E et al (2016) Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol 68:2646\u20132661. https:\/\/doi.org\/10.1002\/art.39783","DOI":"10.1002\/art.39783"},{"key":"1_CR155","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.chom.2019.10.016","volume":"26","author":"N Rolhion","year":"2019","unstructured":"Rolhion N, Chassaing B, Nahori M-A et al (2019) A Listeria monocytogenes bacteriocin can target the commensal Prevotella copri and modulate intestinal infection. Cell Host Microbe 26:691\u2013701.e5. https:\/\/doi.org\/10.1016\/j.chom.2019.10.016","journal-title":"Cell Host Microbe"},{"key":"1_CR156","doi-asserted-by":"publisher","unstructured":"Chriswell ME, Lefferts AR, Clay MR et al (2022) Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum. Sci Transl Med 14:eabn5166. https:\/\/doi.org\/10.1126\/scitranslmed.abn5166","DOI":"10.1126\/scitranslmed.abn5166"}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-26163-3_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:04:23Z","timestamp":1682323463000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-26163-3_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031261626","9783031261633"],"references-count":156,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-26163-3_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"25 April 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}