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We wish to draw the attention of the editor to the following facts, which may be considered as potential conflicts of interest, and to the significant financial contributions to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. 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In so doing, we confirm that we have followed the regulations of our institutions concerning intellectual property.We further confirm that any aspect of the work covered in this manuscript that has involved either experimental animals or human patients has been conducted with the ethical approval of all relevant bodies and that such approvals are acknowledged within the manuscript.We understand that the corresponding author is the sole contact for the editorial process (including editorial manager and direct communications with the office). They are responsible for communicating with the other authors about progress, the submissions of revisions, and the final approval of proofs. We confirm that we have provided a current, correct email address that is accessible by the corresponding author and that has been configured to accept email.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}