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To perform accurate, physically relevant and efficient calculations, the optimal size of the simulation time-step should be selected. In this study, we investigate the selection of an appropriate time-step interval between CFD and DEM models in sand production simulations. The CPU time, speedup and root mean squared relative error of the obtained results are examined to compare the sand production phenomenon at different coupling numbers. Most of the results including the final sand production rate, bond number and bond ratio indicate that the simulations with coupling numbers of <jats:italic>N<\/jats:italic>\u00a0=\u00a010 and <jats:italic>N<\/jats:italic>\u00a0=\u00a0100 produce more accurate results. 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