{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:58:16Z","timestamp":1792407496313,"version":"4.4.0"},"publisher-location":"Cham","reference-count":82,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031381751","type":"print"},{"value":"9783031381768","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-3-031-38176-8_3","type":"book-chapter","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:03:03Z","timestamp":1695729783000},"page":"51-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biological Functions of the KDM2 Family of Histone Demethylases"],"prefix":"10.1007","author":[{"given":"Jaclyn","family":"Andricovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Tzatsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1172\/JCI84014","volume":"126","author":"J Andricovich","year":"2016","unstructured":"Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A (2016) Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Investig 126:905\u2013920","journal-title":"J Clin Investig"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrm3915","volume":"16","author":"KK Biggar","year":"2015","unstructured":"Biggar KK, Li SS (2015) Non-histone protein methylation as a regulator of cellular signalling and function. Nat Rev Mol Cell Biol 16:5\u201317","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.cell.2014.05.004","volume":"157","author":"NP Blackledge","year":"2014","unstructured":"Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y et al (2014) Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell 157:1445\u20131459","journal-title":"Cell"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.04.009","volume":"38","author":"NP Blackledge","year":"2010","unstructured":"Blackledge NP, Zhou JC, Tolstorukov MY, Farcas AM, Park PJ, Klose RJ (2010) CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell 38:179\u2013190","journal-title":"Mol Cell"},{"key":"3_CR5","doi-asserted-by":"crossref","unstructured":"Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H et al (2016) KDM2A integrates DNA and histone modification signals through a CXXC\/PHD module and direct interaction with HP1. Nucleic Acids Res","DOI":"10.1093\/nar\/gkw979"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/ng.3272","volume":"47","author":"M Boulard","year":"2015","unstructured":"Boulard M, Edwards JR, Bestor TH (2015) FBXL10 protects polycomb-bound genes from hypermethylation. Nat Genet 47:479\u2013485","journal-title":"Nat Genet"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13072-016-0069-1","volume":"9","author":"M Boulard","year":"2016","unstructured":"Boulard M, Edwards JR, Bestor TH (2016) Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10. Epigenetics Chromatin 9:22","journal-title":"Epigenetics Chromatin"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/cmdc.201100026","volume":"6","author":"KH Chang","year":"2011","unstructured":"Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR (2011) Inhibition of histone demethylases by 4-carboxy-2,2\u2019-bipyridyl compounds. ChemMedChem 6:759\u2013764","journal-title":"ChemMedChem"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1101\/gad.246561.114","volume":"28","author":"Z Cheng","year":"2014","unstructured":"Cheng Z, Cheung P, Kuo AJ, Yukl ET, Wilmot CM, Gozani O, Patel DJ (2014) A molecular threading mechanism underlies jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev 28:1758\u20131771","journal-title":"Genes Dev"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0968-0004(00)01700-X","volume":"26","author":"PM Clissold","year":"2001","unstructured":"Clissold PM, Ponting CP (2001) JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Trends Biochem Sci 26:7\u20139","journal-title":"Trends Biochem Sci"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/j.celrep.2014.04.012","volume":"7","author":"S Cooper","year":"2014","unstructured":"Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge NP, De Marco V, Elderkin S, Koseki H, Klose R et al (2014) Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep 7:1456\u20131470","journal-title":"Cell Rep"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"13661","DOI":"10.1038\/ncomms13661","volume":"7","author":"S Cooper","year":"2016","unstructured":"Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K et al (2016) Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun 7:13661","journal-title":"Nat Commun"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1016\/j.yexcr.2013.07.008","volume":"319","author":"R Dong","year":"2013","unstructured":"Dong R, Yao R, Du J, Wang S, Fan Z (2013) Depletion of histone demethylase KDM2A enhanced the adipogenic and chondrogenic differentiation potentials of stem cells from apical papilla. Exp Cell Res 319:2874\u20132882","journal-title":"Exp Cell Res"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/stem.1255","volume":"31","author":"J Du","year":"2013","unstructured":"Du J, Ma Y, Ma P, Wang S, Fan Z (2013) Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6 corepressor inhibits osteo\/dentinogenic differentiation. Stem Cells 31:126\u2013136","journal-title":"Stem Cells"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1039\/C4MD00291A","volume":"5","author":"KS England","year":"2014","unstructured":"England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, von Delft F, Burgess-Brown NA et al (2014) Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm 5:1879\u20131886","journal-title":"Medchemcomm"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.tcb.2016.04.009","volume":"26","author":"M Entrevan","year":"2016","unstructured":"Entrevan M, Schuettengruber B, Cavalli G (2016) Regulation of genome architecture and function by polycomb proteins. Trends Cell Biol 26:511\u2013525","journal-title":"Trends Cell Biol"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ng.621","volume":"42","author":"T Ernst","year":"2010","unstructured":"Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, Zoi K, Ross FM, Reiter A et al (2010) Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 42:722\u2013726","journal-title":"Nat Genet"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"5055","DOI":"10.1128\/MCB.00127-07","volume":"27","author":"J Fang","year":"2007","unstructured":"Fang J, Hogan GJ, Liang G, Lieb JD, Zhang Y (2007) The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2. Mol Cell Biol 27:5055\u20135065","journal-title":"Mol Cell Biol"},{"key":"3_CR19","doi-asserted-by":"crossref","unstructured":"Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW et al (2012) KDM2B links the polycomb repressive complex 1 (PRC1) to recognition of CpG islands. eLife 1:e00205","DOI":"10.7554\/eLife.00205"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.mcn.2011.01.001","volume":"46","author":"T Fukuda","year":"2011","unstructured":"Fukuda T, Tokunaga A, Sakamoto R, Yoshida N (2011) Fbxl10\/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci 46:614\u2013624","journal-title":"Mol Cell Neurosci"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"39931","DOI":"10.18632\/oncotarget.9539","volume":"7","author":"M Gale","year":"2016","unstructured":"Gale M, Sayegh J, Cao J, Norcia M, Gareiss P, Hoyer D, Merkel JS, Yan Q (2016) Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget 7:39931\u201339944","journal-title":"Oncotarget"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11010-013-1633-7","volume":"379","author":"R Gao","year":"2013","unstructured":"Gao R, Dong R, Du J, Ma P, Wang S, Fan Z (2013) Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15INK4B and p27Kip1. Mol Cell Biochem 379:115\u2013122","journal-title":"Mol Cell Biochem"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.molcel.2012.01.002","volume":"45","author":"Z Gao","year":"2012","unstructured":"Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D (2012) PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 45:344\u2013356","journal-title":"Mol Cell"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"6880","DOI":"10.1128\/MCB.00630-06","volume":"26","author":"MD Gearhart","year":"2006","unstructured":"Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (2006) Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol 26:6880\u20136889","journal-title":"Mol Cell Biol"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1182\/blood-2011-07-365320","volume":"118","author":"V Grossmann","year":"2011","unstructured":"Grossmann V, Tiacci E, Holmes AB, Kohlmann A, Martelli MP, Kern W, Spanhol-Rosseto A, Klein HU, Dugas M, Schindela S et al (2011) Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 118:6153\u20136163","journal-title":"Blood"},{"key":"3_CR26","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1016\/j.bmcl.2009.03.098","volume":"19","author":"S Hamada","year":"2009","unstructured":"Hamada S, Kim TD, Suzuki T, Itoh Y, Tsumoto H, Nakagawa H, Janknecht R, Miyata N (2009) Synthesis and activity of N-oxalylglycine and its derivatives as jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett 19:2852\u20132855","journal-title":"Bioorg Med Chem Lett"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.1021\/jm1003655","volume":"53","author":"S Hamada","year":"2010","unstructured":"Hamada S, Suzuki T, Mino K, Koseki K, Oehme F, Flamme I, Ozasa H, Itoh Y, Ogasawara D, Komaarashi H et al (2010) Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem 53:5629\u20135638","journal-title":"J Med Chem"},{"key":"3_CR28","doi-asserted-by":"crossref","unstructured":"Han XR, Zha Z, Yuan HX, Feng X, Xia YK, Lei QY, Guan KL, Xiong Y (2016) KDM2B\/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene","DOI":"10.1038\/onc.2015.482"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1182\/blood-2010-10-312736","volume":"117","author":"J He","year":"2011","unstructured":"He J, Nguyen AT, Zhang Y (2011) KDM2b\/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 117:3869\u20133880","journal-title":"Blood"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ncb2702","volume":"15","author":"J He","year":"2013","unstructured":"He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y (2013) Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol 15:373\u2013384","journal-title":"Nat Cell Biol"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1038\/onc.2015.405","volume":"35","author":"LM Heltemes-Harris","year":"2016","unstructured":"Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA (2016) Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. Oncogene 35:3454\u20133464","journal-title":"Oncogene"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/ncb2870","volume":"15","author":"HT Huang","year":"2013","unstructured":"Huang HT, Kathrein KL, Barton A, Gitlin Z, Huang YH, Ward TP, Hofmann O, Dibiase A, Song A, Tyekucheva S et al (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol 15:1516\u20131525","journal-title":"Nat Cell Biol"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature06092","volume":"449","author":"J Huang","year":"2007","unstructured":"Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T et al (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449:105\u2013108","journal-title":"Nature"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mod.2014.10.001","volume":"135","author":"E Kawakami","year":"2015","unstructured":"Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N (2015) The histone demethylase Fbxl11\/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Dev 135:31\u201342","journal-title":"Mech Dev"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"e15535","DOI":"10.1371\/journal.pone.0015535","volume":"5","author":"ON King","year":"2010","unstructured":"King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P et al (2010) Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS ONE 5:e15535","journal-title":"PLoS ONE"},{"issue":"697\u2013709","key":"3_CR36","first-page":"e695","volume":"39","author":"T Konuma","year":"2011","unstructured":"Konuma T, Nakamura S, Miyagi S, Negishi M, Chiba T, Oguro H, Yuan J, Mochizuki-Kashio M, Ichikawa H, Miyoshi H et al (2011) Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Exp Hematol 39(697\u2013709):e695","journal-title":"Exp Hematol"},{"key":"3_CR37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nrm3327","volume":"13","author":"SM Kooistra","year":"2012","unstructured":"Kooistra SM, Helin K (2012) Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 13:297\u2013311","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3_CR38","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/j.1742-4658.2012.08567.x","volume":"279","author":"LH Kristensen","year":"2012","unstructured":"Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M (2012) Studies of H3K4me3 demethylation by KDM5B\/Jarid1B\/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. FEBS J 279:1905\u20131914","journal-title":"FEBS J"},{"key":"3_CR39","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nature11262","volume":"488","author":"L Kruidenier","year":"2012","unstructured":"Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488:404\u2013408","journal-title":"Nature"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00439-016-1668-4","volume":"135","author":"JD Labonne","year":"2016","unstructured":"Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG (2016) An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Hum Genet 135:757\u2013771","journal-title":"Hum Genet"},{"key":"3_CR41","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1101\/gad.484208","volume":"22","author":"A Lagarou","year":"2008","unstructured":"Lagarou A, Mohd-Sarip A, Moshkin YM, Chalkley GE, Bezstarosti K, Demmers JA, Verrijzer CP (2008) dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during polycomb group silencing. Genes Dev 22:2799\u20132810","journal-title":"Genes Dev"},{"key":"3_CR42","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.stem.2014.05.006","volume":"14","author":"A Laugesen","year":"2014","unstructured":"Laugesen A, Helin K (2014) Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14:735\u2013751","journal-title":"Cell Stem Cell"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/nature08290","volume":"460","author":"H Li","year":"2009","unstructured":"Li H, Collado M, Villasante A, Strati K, Ortega S, Canamero M, Blasco MA, Serrano M (2009) The Ink4\/Arf locus is a barrier for iPS cell reprogramming. Nature 460:1136\u20131139","journal-title":"Nature"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ncb2483","volume":"14","author":"G Liang","year":"2012","unstructured":"Liang G, He J, Zhang Y (2012) Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol 14:457\u2013466","journal-title":"Nat Cell Biol"},{"key":"3_CR45","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.devcel.2015.04.006","volume":"33","author":"L Lu","year":"2015","unstructured":"Lu L, Gao Y, Zhang Z, Cao Q, Zhang X, Zou J, Cao Y (2015) Kdm2a\/b lysine demethylases regulate canonical Wnt signaling by modulating the stability of nuclear beta-catenin. Dev Cell 33:660\u2013674","journal-title":"Dev Cell"},{"key":"3_CR46","doi-asserted-by":"publisher","first-page":"16339","DOI":"10.1073\/pnas.0908560106","volume":"106","author":"T Lu","year":"2009","unstructured":"Lu T, Jackson MW, Singhi AD, Kandel ES, Yang M, Zhang Y, Gudkov AV, Stark GR (2009) Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. Proc Natl Acad Sci USA 106:16339\u201316344","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1073\/pnas.0912493107","volume":"107","author":"T Lu","year":"2010","unstructured":"Lu T, Jackson MW, Wang B, Yang M, Chance MR, Miyagi M, Gudkov AV, Stark GR (2010) Regulation of NF-kappaB by NSD1\/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci USA 107:46\u201351","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR48","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1021\/acs.jmedchem.5b01758","volume":"59","author":"TE McAllister","year":"2016","unstructured":"McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ (2016) Recent progress in histone demethylase inhibitors. J Med Chem 59:1308\u20131329","journal-title":"J Med Chem"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature13605","volume":"514","author":"P Ntziachristos","year":"2014","unstructured":"Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B et al (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature 514:513\u2013517","journal-title":"Nature"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1095\/biolreprod.115.135988","volume":"94","author":"M Ozawa","year":"2016","unstructured":"Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N (2016) The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice. Biol Reprod 94:92","journal-title":"Biol Reprod"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/ng.892","volume":"43","author":"L Pasqualucci","year":"2011","unstructured":"Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O et al (2011) Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 43:830\u2013837","journal-title":"Nat Genet"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1073\/pnas.0711865105","volume":"105","author":"R Pfau","year":"2008","unstructured":"Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN (2008) Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci USA 105:1907\u20131912","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR53","doi-asserted-by":"crossref","unstructured":"Piunti A, Shilatifard A (2016) Epigenetic balance of gene expression by polycomb and COMPASS families. Science 352:aad9780","DOI":"10.1126\/science.aad9780"},{"key":"3_CR54","doi-asserted-by":"crossref","unstructured":"Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ (2016) RYBP stimulates PRC1 to shape chromatin-based communication between polycomb repressive complexes. eLife 5","DOI":"10.7554\/eLife.18591"},{"key":"3_CR55","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1021\/jm800936s","volume":"51","author":"NR Rose","year":"2008","unstructured":"Rose NR, Ng SS, Mecinovic J, Lienard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ (2008) Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem 51:7053\u20137056","journal-title":"J Med Chem"},{"key":"3_CR56","doi-asserted-by":"publisher","first-page":"6639","DOI":"10.1021\/jm300677j","volume":"55","author":"NR Rose","year":"2012","unstructured":"Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2\/7 histone demethylases. J Med Chem 55:6639\u20136643","journal-title":"J Med Chem"},{"key":"3_CR57","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1101\/gad.235184.113","volume":"28","author":"R Salama","year":"2014","unstructured":"Salama R, Sadaie M, Hoare M, Narita M (2014) Cellular senescence and its effector programs. Genes Dev 28:99\u2013114","journal-title":"Genes Dev"},{"key":"3_CR58","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1074\/mcp.M600275-MCP200","volume":"6","author":"C Sanchez","year":"2007","unstructured":"Sanchez C, Sanchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M (2007) Proteomics analysis of Ring1B\/Rnf2 interactors identifies a novel complex with the Fbxl10\/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mole Cell Proteomics MCP 6:820\u2013834","journal-title":"Mole Cell Proteomics MCP"},{"key":"3_CR59","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.cell.2007.02.009","volume":"128","author":"B Schuettengruber","year":"2007","unstructured":"Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G (2007) Genome regulation by polycomb and trithorax proteins. Cell 128:735\u2013745","journal-title":"Cell"},{"key":"3_CR60","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941\u2013953","journal-title":"Cell"},{"key":"3_CR61","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.molcel.2013.02.013","volume":"49","author":"JA Simon","year":"2013","unstructured":"Simon JA, Kingston RE (2013) Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell 49:808\u2013824","journal-title":"Mol Cell"},{"key":"3_CR62","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nrm3582","volume":"14","author":"JR Skaar","year":"2013","unstructured":"Skaar JR, Pagan JK, Pagano M (2013) Mechanisms and function of substrate recruitment by F-box proteins. Nat Rev Mol Cell Biol 14:369\u2013381","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3_CR63","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1080\/15476286.2016.1144009","volume":"13","author":"MR Sorenson","year":"2016","unstructured":"Sorenson MR, Jha DK, Ucles SA, Flood DM, Strahl BD, Stevens SW, Kress TL (2016) Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae. RNA Biol 13:412\u2013426","journal-title":"RNA Biol"},{"key":"3_CR64","doi-asserted-by":"publisher","first-page":"7222","DOI":"10.1021\/jm400624b","volume":"56","author":"T Suzuki","year":"2013","unstructured":"Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M et al (2013) Identification of the KDM2\/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem 56:7222\u20137231","journal-title":"J Med Chem"},{"key":"3_CR65","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663\u2013676","journal-title":"Cell"},{"key":"3_CR66","doi-asserted-by":"publisher","first-page":"e45634","DOI":"10.1371\/journal.pone.0045634","volume":"7","author":"S Testoni","year":"2012","unstructured":"Testoni S, Bartolone E, Rossi M, Patrignani A, Bruggmann R, Lichtner P, Tetens J, Gentile A, Drogemuller C (2012) KDM2B is implicated in bovine lethal multi-organic developmental dysplasia. PLoS ONE 7:e45634","journal-title":"PLoS ONE"},{"key":"3_CR67","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ccr.2009.12.034","volume":"17","author":"AT Thiel","year":"2010","unstructured":"Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA et al (2010) MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell 17:148\u2013159","journal-title":"Cancer Cell"},{"key":"3_CR68","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1038\/sj.emboj.7601892","volume":"26","author":"SC Trewick","year":"2007","unstructured":"Trewick SC, Minc E, Antonelli R, Urano T, Allshire RC (2007) The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin. EMBO J 26:4670\u20134682","journal-title":"EMBO J"},{"key":"3_CR69","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nature04433","volume":"439","author":"Y Tsukada","year":"2006","unstructured":"Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature 439:811\u2013816","journal-title":"Nature"},{"key":"3_CR70","doi-asserted-by":"publisher","first-page":"14262","DOI":"10.1074\/jbc.M609900200","volume":"282","author":"S Tu","year":"2007","unstructured":"Tu S, Bulloch EM, Yang L, Ren C, Huang WC, Hsu PH, Chen CH, Liao CL, Yu HM, Lo WS et al (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282:14262\u201314271","journal-title":"J Biol Chem"},{"key":"3_CR71","first-page":"727","volume":"123","author":"A Tzatsos","year":"2013","unstructured":"Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ et al (2013) KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Investig 123:727\u2013739","journal-title":"J Clin Investig"},{"key":"3_CR72","doi-asserted-by":"publisher","first-page":"33061","DOI":"10.1074\/jbc.M111.257667","volume":"286","author":"A Tzatsos","year":"2011","unstructured":"Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N (2011) Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J Biol Chem 286:33061\u201333069","journal-title":"J Biol Chem"},{"key":"3_CR73","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1073\/pnas.0813139106","volume":"106","author":"A Tzatsos","year":"2009","unstructured":"Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN (2009) Ndy1\/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a\/Arf locus. Proc Natl Acad Sci USA 106:2641\u20132646","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR74","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1182\/blood-2014-03-562694","volume":"125","author":"T Ueda","year":"2015","unstructured":"Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H et al (2015) Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 125:3437\u20133446","journal-title":"Blood"},{"key":"3_CR75","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/nature08285","volume":"460","author":"J Utikal","year":"2009","unstructured":"Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460:1145\u20131148","journal-title":"Nature"},{"key":"3_CR76","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nchembio.2085","volume":"12","author":"M Vinogradova","year":"2016","unstructured":"Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W et al (2016) An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol 12:531\u2013538","journal-title":"Nat Chem Biol"},{"key":"3_CR77","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.1172\/JCI68642","volume":"123","author":"KW Wagner","year":"2013","unstructured":"Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y et al (2013) KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1\/2 signaling. J Clin Investig 123:5231\u20135246","journal-title":"J Clin Investig"},{"key":"3_CR78","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.stem.2011.10.005","volume":"9","author":"T Wang","year":"2011","unstructured":"Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G et al (2011) The histone demethylases Jhdm1a\/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 9:575\u2013587","journal-title":"Cell Stem Cell"},{"key":"3_CR79","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.str.2016.07.011","volume":"24","author":"SJ Wong","year":"2016","unstructured":"Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, Artigas JA, Lee OJ, Demeler B, Hart PJ et al (2016) KDM2B recruitment of the polycomb group complex, PRC1.1, requires cooperation between PCGF1 and BCORL1. Structure 24:1795\u20131801","journal-title":"Structure"},{"key":"3_CR80","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.molcel.2013.01.016","volume":"49","author":"X Wu","year":"2013","unstructured":"Wu X, Johansen JV, Helin K (2013) Fbxl10\/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell 49:1134\u20131146","journal-title":"Mol Cell"},{"key":"3_CR81","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nature04815","volume":"442","author":"J Wysocka","year":"2006","unstructured":"Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P et al (2006) A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 442:86\u201390","journal-title":"Nature"},{"key":"3_CR82","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1158\/2159-8290.CD-16-0058","volume":"6","author":"L Zhu","year":"2016","unstructured":"Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C et al (2016) ASH1L links histone H3 lysine 36 dimethylation to MLL leukemia. Cancer Discov 6:770\u2013783","journal-title":"Cancer Discov"}],"container-title":["Advances in Experimental Medicine and Biology","Targeting Lysine Demethylases in Cancer and Other Human Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-38176-8_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:04:07Z","timestamp":1695729847000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-38176-8_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031381751","9783031381768"],"references-count":82,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-38176-8_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"27 September 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}