{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:00:03Z","timestamp":1793260803500,"version":"4.5.0"},"publisher-location":"Cham","reference-count":129,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031440861","type":"print"},{"value":"9783031440878","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-3-031-44087-8_19","type":"book-chapter","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T07:06:58Z","timestamp":1718608018000},"page":"365-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac Metabolism"],"prefix":"10.1007","author":[{"given":"Silvia","family":"Martin-Puig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Menendez-Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"issue":"2","key":"19_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/FJC.0b013e3181e74a14","volume":"56","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Jaswal JS. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J Cardiovasc Pharmacol. 2010;56(2):130\u201340. https:\/\/doi.org\/10.1097\/FJC.0b013e3181e74a14.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"19_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F","volume":"220","author":"YM Lee","year":"2001","unstructured":"Lee YM, Jeong CH, Koo SY, Son MJ, Song HS, Bae SK, et al. Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev Dyn. 2001;220(2):175\u201386. https:\/\/doi.org\/10.1002\/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F.","journal-title":"Dev Dyn"},{"issue":"2B","key":"19_CR3","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1051\/rnd:19860413","volume":"26","author":"P Ferre","year":"1986","unstructured":"Ferre P, Decaux JF, Issad T, Girard J. Changes in energy metabolism during the suckling and weaning period in the newborn. Reprod Nutr Dev. 1986;26(2B):619\u201331. https:\/\/doi.org\/10.1051\/rnd:19860413.","journal-title":"Reprod Nutr Dev"},{"issue":"3","key":"19_CR4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1152\/physrev.1999.79.3.635","volume":"79","author":"B Ostadal","year":"1999","unstructured":"Ostadal B, Ostadalova I, Dhalla NS. Development of cardiac sensitivity to oxygen deficiency: comparative and ontogenetic aspects. Physiol Rev. 1999;79(3):635\u201359. https:\/\/doi.org\/10.1152\/physrev.1999.79.3.635.","journal-title":"Physiol Rev"},{"issue":"5930","key":"19_CR5","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029\u201333. https:\/\/doi.org\/10.1126\/science.1160809.","journal-title":"Science"},{"issue":"4","key":"19_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1085\/jgp.201310968","volume":"142","author":"G Calmettes","year":"2013","unstructured":"Calmettes G, John SA, Weiss JN, Ribalet B. Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes. J Gen Physiol. 2013;142(4):425\u201336. https:\/\/doi.org\/10.1085\/jgp.201310968.","journal-title":"J Gen Physiol"},{"issue":"Suppl 1","key":"19_CR7","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1038\/ncpcardio0766","volume":"4","author":"S Chung","year":"2007","unstructured":"Chung S, Dzeja PP, Faustino RS, Perez-Terzic C, Behfar A, Terzic A. Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med. 2007;4(Suppl 1):S60\u20137. https:\/\/doi.org\/10.1038\/ncpcardio0766.","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"5","key":"19_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.devcel.2015.04.021","volume":"33","author":"N Guimaraes-Camboa","year":"2015","unstructured":"Guimaraes-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, et al. HIF1alpha represses cell stress pathways to allow proliferation of hypoxic fetal cardiomyocytes. Dev Cell. 2015;33(5):507\u201321. https:\/\/doi.org\/10.1016\/j.devcel.2015.04.021.","journal-title":"Dev Cell"},{"issue":"6","key":"19_CR9","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.devcel.2016.11.012","volume":"39","author":"I Menendez-Montes","year":"2016","unstructured":"Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, et al. Myocardial VHL-HIF signaling controls an embryonic metabolic switch essential for cardiac maturation. Dev Cell. 2016;39(6):724\u201339. https:\/\/doi.org\/10.1016\/j.devcel.2016.11.012.","journal-title":"Dev Cell"},{"issue":"2","key":"19_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102124","volume":"24","author":"I Menendez-Montes","year":"2021","unstructured":"Menendez-Montes I, Escobar B, Gomez MJ, Albendea-Gomez T, Palacios B, Bonzon-Kulichenko E, et al. Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021b;24(2):102124. https:\/\/doi.org\/10.1016\/j.isci.2021.102124.","journal-title":"iScience"},{"issue":"9","key":"19_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001666","volume":"11","author":"RA Breckenridge","year":"2013","unstructured":"Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, et al. Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol. 2013;11(9):e1001666. https:\/\/doi.org\/10.1371\/journal.pbio.1001666.","journal-title":"PLoS Biol"},{"issue":"3","key":"19_CR12","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.devcel.2011.08.008","volume":"21","author":"JR Hom","year":"2011","unstructured":"Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA Jr. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell. 2011;21(3):469\u201378. https:\/\/doi.org\/10.1016\/j.devcel.2011.08.008.","journal-title":"Dev Cell"},{"issue":"9","key":"19_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/0022-2828(92)91862-y","volume":"24","author":"HD Kim","year":"1992","unstructured":"Kim HD, Kim DJ, Lee IJ, Rah BJ, Sawa Y, Schaper J. Human fetal heart development after mid-term: morphometry and ultrastructural study. J Mol Cell Cardiol. 1992;24(9):949\u201365. https:\/\/doi.org\/10.1016\/0022-2828(92)91862-y.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"19_CR14","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/(SICI)1097-0185(199811)252:3<383::AID-AR6>3.0.CO;2-Z","volume":"252","author":"TH Shepard","year":"1998","unstructured":"Shepard TH, Muffley LA, Smith LT. Ultrastructural study of mitochondria and their cristae in embryonic rats and primate (N. nemistrina). Anat Rec. 1998;252(3):383\u201392. https:\/\/doi.org\/10.1002\/(SICI)1097-0185(199811)252:3<383::AID-AR6>3.0.CO;2-Z.","journal-title":"Anat Rec"},{"issue":"6","key":"19_CR15","first-page":"713","volume":"32","author":"HD Sybers","year":"1975","unstructured":"Sybers HD, Ingwall JS, De Luca MA. Fetal mouse heart in organ structure: ultrastructure. Lab Investig. 1975;32(6):713\u20139. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1171338","journal-title":"Lab Investig"},{"key":"19_CR16","doi-asserted-by":"publisher","first-page":"e50161","DOI":"10.7554\/eLife.50161","volume":"8","author":"R Fukuda","year":"2019","unstructured":"Fukuda R, Aharonov A, Ong YT, Stone OA, El-Brolosy M, Maischein HM, et al. Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. Elife. 2019;8:e50161. https:\/\/doi.org\/10.7554\/eLife.50161.","journal-title":"Elife"},{"issue":"10","key":"19_CR17","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1161\/01.RES.0000338613.89841.c1","volume":"103","author":"J Krishnan","year":"2008","unstructured":"Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC. Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function. Circ Res. 2008;103(10):1139\u201346. https:\/\/doi.org\/10.1161\/01.RES.0000338613.89841.c1.","journal-title":"Circ Res"},{"issue":"3","key":"19_CR18","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/s1097-2765(03)00105-9","volume":"11","author":"HP Harding","year":"2003","unstructured":"Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003;11(3):619\u201333. https:\/\/doi.org\/10.1016\/s1097-2765(03)00105-9.","journal-title":"Mol Cell"},{"key":"19_CR19","volume-title":"Principles of biochemistry","author":"AL Lehninger","year":"1993","unstructured":"Lehninger AL, Nelson DL, Cox MM. Principles of biochemistry. New York: Worth Publishers; 1993."},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"e29330","DOI":"10.7554\/eLife.29330","volume":"6","author":"H Nakano","year":"2017","unstructured":"Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, et al. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017;6:e29330. https:\/\/doi.org\/10.7554\/eLife.29330.","journal-title":"Elife"},{"issue":"4","key":"19_CR21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/aja.1002040403","volume":"204","author":"B Delorme","year":"1995","unstructured":"Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, et al. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn. 1995;204(4):358\u201371. https:\/\/doi.org\/10.1002\/aja.1002040403.","journal-title":"Dev Dyn"},{"issue":"10","key":"19_CR22","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","volume":"128","author":"GD Lopaschuk","year":"2021","unstructured":"Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Cardiac energy metabolism in heart failure. Circ Res. 2021;128(10):1487\u2013513. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.318241.","journal-title":"Circ Res"},{"issue":"12","key":"19_CR23","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/cvr\/26.12.1172","volume":"26","author":"GD Lopaschuk","year":"1992","unstructured":"Lopaschuk GD, Collins-Nakai RL, Itoi T. Developmental changes in energy substrate use by the heart. Cardiovasc Res. 1992;26(12):1172\u201380. https:\/\/doi.org\/10.1093\/cvr\/26.12.1172.","journal-title":"Cardiovasc Res"},{"key":"19_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3389\/fphys.2018.00365","volume":"9","author":"MM Lalowski","year":"2018","unstructured":"Lalowski MM, Bjork S, Finckenberg P, Soliymani R, Tarkia M, Calza G, et al. Characterizing the key metabolic pathways of the neonatal mouse heart using a quantitative combinatorial omics approach. Front Physiol. 2018;9:365. https:\/\/doi.org\/10.3389\/fphys.2018.00365.","journal-title":"Front Physiol"},{"issue":"3","key":"19_CR25","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","volume":"157","author":"BN Puente","year":"2014","unstructured":"Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565\u201379. https:\/\/doi.org\/10.1016\/j.cell.2014.03.032.","journal-title":"Cell"},{"issue":"34","key":"19_CR26","doi-asserted-by":"publisher","first-page":"e2101674118","DOI":"10.1073\/pnas.2101674118","volume":"118","author":"I Menendez-Montes","year":"2021","unstructured":"Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee S, Szweda LI, et al. Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes. Proc Natl Acad Sci U S A. 2021a;118(34):e2101674118. https:\/\/doi.org\/10.1073\/pnas.2101674118.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5601","key":"19_CR27","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298(5601):2188\u201390. https:\/\/doi.org\/10.1126\/science.1077857.","journal-title":"Science"},{"issue":"6020","key":"19_CR28","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078\u201380. https:\/\/doi.org\/10.1126\/science.1200708.","journal-title":"Science"},{"issue":"24","key":"19_CR29","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","volume":"138","author":"L Ye","year":"2018","unstructured":"Ye L, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, et al. Early regenerative capacity in the porcine heart. Circulation. 2018;138(24):2798\u2013808. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.031542.","journal-title":"Circulation"},{"issue":"24","key":"19_CR30","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","volume":"138","author":"W Zhu","year":"2018","unstructured":"Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, et al. Regenerative potential of neonatal porcine hearts. Circulation. 2018;138(24):2809\u201316. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.034886.","journal-title":"Circulation"},{"issue":"7288","key":"19_CR31","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling C, Sleep E, Raya M, Marti M, Raya A, Izpisua Belmonte JC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 2010;464(7288):606\u20139. https:\/\/doi.org\/10.1038\/nature08899.","journal-title":"Nature"},{"issue":"7288","key":"19_CR32","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nature08804","volume":"464","author":"K Kikuchi","year":"2010","unstructured":"Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, et al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010;464(7288):601\u20135. https:\/\/doi.org\/10.1038\/nature08804.","journal-title":"Nature"},{"issue":"7432","key":"19_CR33","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013;493(7432):433\u20136. https:\/\/doi.org\/10.1038\/nature11682.","journal-title":"Nature"},{"issue":"8","key":"19_CR34","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","volume":"28","author":"F Li","year":"1996","unstructured":"Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol. 1996;28(8):1737\u201346. https:\/\/doi.org\/10.1006\/jmcc.1996.0163.","journal-title":"J Mol Cell Cardiol"},{"issue":"5 Pt 2","key":"19_CR35","doi-asserted-by":"publisher","first-page":"H2183","DOI":"10.1152\/ajpheart.1996.271.5.H2183","volume":"271","author":"MH Soonpaa","year":"1996","unstructured":"Soonpaa MH, Kim KK, Pajak L, Franklin M, Field LJ. Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Phys. 1996;271(5 Pt 2):H2183\u20139. https:\/\/doi.org\/10.1152\/ajpheart.1996.271.5.H2183.","journal-title":"Am J Phys"},{"issue":"7","key":"19_CR36","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","volume":"161","author":"O Bergmann","year":"2015","unstructured":"Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, et al. Dynamics of cell generation and turnover in the human heart. Cell. 2015;161(7):1566\u201375. https:\/\/doi.org\/10.1016\/j.cell.2015.05.026.","journal-title":"Cell"},{"issue":"4","key":"19_CR37","doi-asserted-by":"publisher","first-page":"R476","DOI":"10.1152\/ajpregu.00188.2020","volume":"319","author":"AJ Mouton","year":"2020","unstructured":"Mouton AJ, Hall JE. Novel roles of immunometabolism and nonmyocyte metabolism in cardiac remodeling and injury. Am J Physiol Regul Integr Comp Physiol. 2020;319(4):R476\u201384. https:\/\/doi.org\/10.1152\/ajpregu.00188.2020.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"19_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1113\/JP280572","volume":"599","author":"SJ Kierans","year":"2021","unstructured":"Kierans SJ, Taylor CT. Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol. 2021;599(1):23\u201337. https:\/\/doi.org\/10.1113\/JP280572.","journal-title":"J Physiol"},{"issue":"1588","key":"19_CR39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1126\/science.61.1588.575","volume":"61","author":"O Warburg","year":"1925","unstructured":"Warburg O. Iron, the oxygen-carrier of respiration-ferment. Science. 1925;61(1588):575\u201382. https:\/\/doi.org\/10.1126\/science.61.1588.575.","journal-title":"Science"},{"issue":"3","key":"19_CR40","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1158\/2159-8290.CD-19-0837","volume":"10","author":"L Hu","year":"2020","unstructured":"Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, et al. TBK1 is a synthetic lethal target in cancer with VHL loss. Cancer Discov. 2020;10(3):460\u201375. https:\/\/doi.org\/10.1158\/2159-8290.CD-19-0837.","journal-title":"Cancer Discov"},{"issue":"5","key":"19_CR41","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ccr.2009.09.029","volume":"16","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 2009;16(5):413\u201324. https:\/\/doi.org\/10.1016\/j.ccr.2009.09.029.","journal-title":"Cancer Cell"},{"key":"19_CR42","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/srep00788","volume":"2","author":"R Bienes-Martinez","year":"2012","unstructured":"Bienes-Martinez R, Ordonez A, Feijoo-Cuaresma M, Corral-Escariz M, Mateo G, Stenina O, et al. Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1. Sci Rep. 2012;2:788. https:\/\/doi.org\/10.1038\/srep00788.","journal-title":"Sci Rep"},{"issue":"14","key":"19_CR43","doi-asserted-by":"publisher","first-page":"8360","DOI":"10.1074\/jbc.273.14.8360","volume":"273","author":"SM Wood","year":"1998","unstructured":"Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. J Biol Chem. 1998;273(14):8360\u20138. https:\/\/doi.org\/10.1074\/jbc.273.14.8360.","journal-title":"J Biol Chem"},{"issue":"7559","key":"19_CR44","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14582","volume":"523","author":"W Kimura","year":"2015","unstructured":"Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, et al. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature. 2015;523(7559):226\u201330. https:\/\/doi.org\/10.1038\/nature14582.","journal-title":"Nature"},{"issue":"25","key":"19_CR45","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1161\/CIRCULATIONAHA.112.107888","volume":"126","author":"C Jopling","year":"2012","unstructured":"Jopling C, Sune G, Faucherre A, Fabregat C, Izpisua Belmonte JC. Hypoxia induces myocardial regeneration in zebrafish. Circulation. 2012;126(25):3017\u201327. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.107888.","journal-title":"Circulation"},{"issue":"7636","key":"19_CR46","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature20173","volume":"541","author":"Y Nakada","year":"2017","unstructured":"Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, et al. Hypoxia induces heart regeneration in adult mice. Nature. 2017;541(7636):222\u20137. https:\/\/doi.org\/10.1038\/nature20173.","journal-title":"Nature"},{"key":"19_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.702920","volume":"8","author":"J Bae","year":"2021","unstructured":"Bae J, Paltzer WG, Mahmoud AI. The role of metabolism in heart failure and regeneration. Front Cardiovasc Med. 2021a;8:702920. https:\/\/doi.org\/10.3389\/fcvm.2021.702920.","journal-title":"Front Cardiovasc Med"},{"issue":"Pt 3","key":"19_CR48","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1042\/bj2800561","volume":"280","author":"DA Harris","year":"1991","unstructured":"Harris DA, Das AM. Control of mitochondrial ATP synthesis in the heart. Biochem J. 1991;280(Pt 3):561\u201373. https:\/\/doi.org\/10.1042\/bj2800561.","journal-title":"Biochem J"},{"issue":"10","key":"19_CR49","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1161\/RES.0000000000000097","volume":"118","author":"H Taegtmeyer","year":"2016","unstructured":"Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, American Heart Association Council on Basic Cardiovascular Sciences, et al. Assessing cardiac metabolism: a scientific statement from the American Heart Association. Circ Res. 2016;118(10):1659\u2013701. https:\/\/doi.org\/10.1161\/RES.0000000000000097.","journal-title":"Circ Res"},{"issue":"1","key":"19_CR50","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physrev.00015.2009","volume":"90","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010;90(1):207\u201358. https:\/\/doi.org\/10.1152\/physrev.00015.2009.","journal-title":"Physiol Rev"},{"issue":"2","key":"19_CR51","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1023\/a:1015332726303","volume":"7","author":"JJ Lehman","year":"2002","unstructured":"Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail Rev. 2002;7(2):175\u201385. https:\/\/doi.org\/10.1023\/a:1015332726303.","journal-title":"Heart Fail Rev"},{"issue":"6","key":"19_CR52","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.cmet.2009.05.005","volume":"9","author":"J Krishnan","year":"2009","unstructured":"Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, et al. Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab. 2009;9(6):512\u201324. https:\/\/doi.org\/10.1016\/j.cmet.2009.05.005.","journal-title":"Cell Metab"},{"key":"19_CR53","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.physiol.62.1.289","volume":"62","author":"WR MacLellan","year":"2000","unstructured":"MacLellan WR, Schneider MD. Genetic dissection of cardiac growth control pathways. Annu Rev Physiol. 2000;62:289\u2013319. https:\/\/doi.org\/10.1146\/annurev.physiol.62.1.289.","journal-title":"Annu Rev Physiol"},{"issue":"8","key":"19_CR54","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949752","volume":"21","author":"R Fukuda","year":"2020","unstructured":"Fukuda R, Marin-Juez R, El-Sammak H, Beisaw A, Ramadass R, Kuenne C, et al. Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO Rep. 2020;21(8):e49752. https:\/\/doi.org\/10.15252\/embr.201949752.","journal-title":"EMBO Rep"},{"key":"19_CR55","doi-asserted-by":"publisher","first-page":"e50163","DOI":"10.7554\/eLife.50163","volume":"8","author":"H Honkoop","year":"2019","unstructured":"Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, et al. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. Elife. 2019;8:e50163. https:\/\/doi.org\/10.7554\/eLife.50163.","journal-title":"Elife"},{"issue":"5","key":"19_CR56","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/ncb3149","volume":"17","author":"G D\u2019Uva","year":"2015","unstructured":"D\u2019Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol. 2015;17(5):627\u201338. https:\/\/doi.org\/10.1038\/ncb3149.","journal-title":"Nat Cell Biol"},{"issue":"49","key":"19_CR57","doi-asserted-by":"publisher","first-page":"48690","DOI":"10.1074\/jbc.M308862200","volume":"278","author":"L del Peso","year":"2003","unstructured":"del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. The von Hippel Lindau\/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem. 2003;278(49):48690\u20135. https:\/\/doi.org\/10.1074\/jbc.M308862200.","journal-title":"J Biol Chem"},{"issue":"1","key":"19_CR58","doi-asserted-by":"publisher","first-page":"8669","DOI":"10.1038\/s41598-021-88159-x","volume":"11","author":"VM Fajardo","year":"2021","unstructured":"Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, et al. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021;11(1):8669. https:\/\/doi.org\/10.1038\/s41598-021-88159-x.","journal-title":"Sci Rep"},{"issue":"5","key":"19_CR59","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41418-017-0036-9","volume":"25","author":"X Wang","year":"2018","unstructured":"Wang X, Ha T, Liu L, Hu Y, Kao R, Kalbfleisch J, et al. TLR3 mediates repair and regeneration of damaged neonatal heart through glycolysis dependent YAP1 regulated miR-152 expression. Cell Death Differ. 2018;25(5):966\u201382. https:\/\/doi.org\/10.1038\/s41418-017-0036-9.","journal-title":"Cell Death Differ"},{"key":"19_CR60","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fcvm.2018.00068","volume":"5","author":"QG Karwi","year":"2018","unstructured":"Karwi QG, Uddin GM, Ho KL, Lopaschuk GD. Loss of metabolic flexibility in the failing heart. Front Cardiovasc Med. 2018;5:68. https:\/\/doi.org\/10.3389\/fcvm.2018.00068.","journal-title":"Front Cardiovasc Med"},{"issue":"12","key":"19_CR61","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012673","volume":"8","author":"DH Tran","year":"2019","unstructured":"Tran DH, Wang ZV. Glucose metabolism in cardiac hypertrophy and heart failure. J Am Heart Assoc. 2019;8(12):e012673. https:\/\/doi.org\/10.1161\/JAHA.119.012673.","journal-title":"J Am Heart Assoc"},{"issue":"12A","key":"19_CR62","doi-asserted-by":"publisher","first-page":"25H","DOI":"10.1016\/s0002-9149(99)00253-2","volume":"83","author":"LH Young","year":"1999","unstructured":"Young LH, Russell RR 3rd, Yin R, Caplan MJ, Ren J, Bergeron R, et al. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. Am J Cardiol. 1999;83(12A):25H\u201330H. https:\/\/doi.org\/10.1016\/s0002-9149(99)00253-2.","journal-title":"Am J Cardiol"},{"issue":"6538","key":"19_CR63","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.abe2762","volume":"372","author":"M Ogawa","year":"2021","unstructured":"Ogawa M, Geng FS, Humphreys DT, Kristianto E, Sheng DZ, Hui SP, et al. Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science. 2021;372(6538):201\u20135. https:\/\/doi.org\/10.1126\/science.abe2762.","journal-title":"Science"},{"issue":"2","key":"19_CR64","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s42255-020-0169-x","volume":"2","author":"AC Cardoso","year":"2020","unstructured":"Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, et al. Mitochondrial substrate utilization regulates cardiomyocyte cell cycle progression. Nat Metab. 2020a;2(2):167\u201378. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32617517","journal-title":"Nat Metab"},{"key":"19_CR65","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fcell.2019.00042","volume":"7","author":"T Cao","year":"2019","unstructured":"Cao T, Liccardo D, LaCanna R, Zhang X, Lu R, Finck BN, et al. Fatty acid oxidation promotes cardiomyocyte proliferation rate but does not change cardiomyocyte number in infant mice. Front Cell Dev Biol. 2019;7:42. https:\/\/doi.org\/10.3389\/fcell.2019.00042.","journal-title":"Front Cell Dev Biol"},{"key":"19_CR66","volume":"2019","author":"R Roy","year":"2019","unstructured":"Roy R, Leigh T, Gao E, Zhang X, Tian Y. Activation or inhibition of PPARa-mediated fatty acid b-oxidation does not active cardiomyocyte proliferation in normal or infarcted adult mice. bioRxiv. 2019;2019:667964.","journal-title":"bioRxiv."},{"issue":"20","key":"19_CR67","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1161\/CIRCULATIONAHA.120.049952","volume":"143","author":"J Bae","year":"2021","unstructured":"Bae J, Salamon RJ, Brandt EB, Paltzer WG, Zhang Z, Britt EC, et al. Malonate promotes adult cardiomyocyte proliferation and heart regeneration. Circulation. 2021b;143(20):1973\u201386. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.049952.","journal-title":"Circulation"},{"issue":"15","key":"19_CR68","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.3390\/cancers13153769","volume":"13","author":"K Hadrava Vanova","year":"2021","unstructured":"Hadrava Vanova K, Yang C, Meuter L, Neuzil J, Pacak K. Reactive oxygen species: a promising therapeutic target for SDHx-mutated Pheochromocytoma and Paraganglioma. Cancers (Basel). 2021;13(15):3769. https:\/\/doi.org\/10.3390\/cancers13153769.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"19_CR69","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1038\/s41598-018-21361-6","volume":"8","author":"PL Tseng","year":"2018","unstructured":"Tseng PL, Wu WH, Hu TH, Chen CW, Cheng HC, Li CF, et al. Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect. Sci Rep. 2018;8(1):3081. https:\/\/doi.org\/10.1038\/s41598-018-21361-6.","journal-title":"Sci Rep"},{"issue":"15","key":"19_CR70","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.119.043067","volume":"141","author":"A Magadum","year":"2020","unstructured":"Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, et al. Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration. Circulation. 2020;141(15):1249\u201365. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.043067.","journal-title":"Circulation"},{"issue":"29","key":"19_CR71","doi-asserted-by":"publisher","first-page":"14366","DOI":"10.1016\/S0021-9258(18)47947-1","volume":"262","author":"T Noguchi","year":"1987","unstructured":"Noguchi T, Yamada K, Inoue H, Matsuda T, Tanaka T. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem. 1987;262(29):14366\u201371. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3654663","journal-title":"J Biol Chem"},{"issue":"5","key":"19_CR72","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1073\/pnas.0914845107","volume":"107","author":"CV Clower","year":"2010","unstructured":"Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1\/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A. 2010;107(5):1894\u20139. https:\/\/doi.org\/10.1073\/pnas.0914845107.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"19_CR73","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.semcancer.2005.04.009","volume":"15","author":"S Mazurek","year":"2005","unstructured":"Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol. 2005;15(4):300\u20138. https:\/\/doi.org\/10.1016\/j.semcancer.2005.04.009.","journal-title":"Semin Cancer Biol"},{"issue":"1\u20132","key":"19_CR74","first-page":"91","volume":"3","author":"E Eigenbrodt","year":"1992","unstructured":"Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog. 1992;3(1\u20132):91\u2013115. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1532331","journal-title":"Crit Rev Oncog"},{"issue":"5","key":"19_CR75","first-page":"1183","volume":"60","author":"LG Boros","year":"2000","unstructured":"Boros LG, Torday JS, Lim S, Bassilian S, Cascante M, Lee WN. Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res. 2000;60(5):1183\u20135. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10728670","journal-title":"Cancer Res"},{"issue":"7","key":"19_CR76","doi-asserted-by":"publisher","first-page":"551","DOI":"10.18632\/oncotarget.299","volume":"2","author":"W Luo","year":"2011","unstructured":"Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2011;2(7):551\u20136. https:\/\/doi.org\/10.18632\/oncotarget.299.","journal-title":"Oncotarget"},{"issue":"12","key":"19_CR77","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ncb2629","volume":"14","author":"W Yang","year":"2012","unstructured":"Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, et al. ERK1\/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012;14(12):1295\u2013304. https:\/\/doi.org\/10.1038\/ncb2629.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"19_CR78","first-page":"68","volume":"76","author":"DK Das","year":"1987","unstructured":"Das DK, Engelman RM, Rousou JA, Breyer RH. Aerobic vs anaerobic metabolism during ischemia in heart muscle. Ann Chir Gynaecol. 1987;76(1):68\u201376. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3592561","journal-title":"Ann Chir Gynaecol"},{"issue":"6","key":"19_CR79","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","volume":"113","author":"T Doenst","year":"2013","unstructured":"Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013;113(6):709\u201324. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.300376.","journal-title":"Circ Res"},{"key":"19_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114065","volume":"178","author":"J Wang","year":"2020","unstructured":"Wang J, Xue Z, Lin J, Wang Y, Ying H, Lv Q, et al. Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation. Biochem Pharmacol. 2020;178:114065. https:\/\/doi.org\/10.1016\/j.bcp.2020.114065.","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"19_CR81","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1172\/JCI38151","volume":"119","author":"G Lu","year":"2009","unstructured":"Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, et al. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009;119(6):1678\u201387. https:\/\/doi.org\/10.1172\/JCI38151.","journal-title":"J Clin Invest"},{"issue":"12","key":"19_CR82","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1258\/ebm.2012.012025","volume":"237","author":"KJ Drake","year":"2012","unstructured":"Drake KJ, Sidorov VY, McGuinness OP, Wasserman DH, Wikswo JP. Amino acids as metabolic substrates during cardiac ischemia. Exp Biol Med (Maywood). 2012;237(12):1369\u201378. https:\/\/doi.org\/10.1258\/ebm.2012.012025.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"19_CR83","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1083\/jcb.200703099","volume":"178","author":"M Yuneva","year":"2007","unstructured":"Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007;178(1):93\u2013105. https:\/\/doi.org\/10.1083\/jcb.200703099.","journal-title":"J Cell Biol"},{"issue":"7","key":"19_CR84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132402","volume":"10","author":"K Li","year":"2015","unstructured":"Li K, Cui YC, Zhang H, Liu XP, Zhang D, Wu AL, et al. Glutamine reduces the apoptosis of H9C2 cells treated with high-glucose and reperfusion through an oxidation-related mechanism. PLoS One. 2015;10(7):e0132402. https:\/\/doi.org\/10.1371\/journal.pone.0132402.","journal-title":"PLoS One"},{"issue":"10","key":"19_CR85","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1161\/ATVBAHA.117.308848","volume":"37","author":"S Tavakoli","year":"2017","unstructured":"Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, et al. Characterization of macrophage polarization states using combined measurement of 2-deoxyglucose and glutamine accumulation: implications for imaging of atherosclerosis. Arterioscler Thromb Vasc Biol. 2017;37(10):1840\u20138. https:\/\/doi.org\/10.1161\/ATVBAHA.117.308848.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"19_CR86","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.pcad.2019.03.002","volume":"62","author":"JBN Moreira","year":"2019","unstructured":"Moreira JBN, Wohlwend M, Fenk S, Amellem I, Flatberg A, Kraljevic J, et al. Exercise reveals proline dehydrogenase as a potential target in heart failure. Prog Cardiovasc Dis. 2019;62(2):193\u2013202. https:\/\/doi.org\/10.1016\/j.pcad.2019.03.002.","journal-title":"Prog Cardiovasc Dis"},{"issue":"5","key":"19_CR87","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1161\/HYPERTENSIONAHA.118.10919","volume":"72","author":"ZY Zhang","year":"2018","unstructured":"Zhang ZY, Monleon D, Verhamme P, Staessen JA. Branched-chain amino acids as critical switches in health and disease. Hypertension. 2018;72(5):1012\u201322. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.118.10919.","journal-title":"Hypertension"},{"issue":"4","key":"19_CR88","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1161\/CIRCHEARTFAILURE.114.001151","volume":"7","author":"BE Sansbury","year":"2014","unstructured":"Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, et al. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail. 2014;7(4):634\u201342. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.114.001151.","journal-title":"Circ Heart Fail"},{"issue":"1","key":"19_CR89","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12933-019-0892-3","volume":"18","author":"GM Uddin","year":"2019","unstructured":"Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18(1):86. https:\/\/doi.org\/10.1186\/s12933-019-0892-3.","journal-title":"Cardiovasc Diabetol"},{"issue":"11","key":"19_CR90","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011625","volume":"8","author":"M Chen","year":"2019","unstructured":"Chen M, Gao C, Yu J, Ren S, Wang M, Wynn RM, et al. Therapeutic effect of targeting branched-chain amino acid catabolic flux in pressure-overload induced heart failure. J Am Heart Assoc. 2019;8(11):e011625. https:\/\/doi.org\/10.1161\/JAHA.118.011625.","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"19_CR91","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.7150\/thno.44836","volume":"10","author":"Y Li","year":"2020","unstructured":"Li Y, Xiong Z, Yan W, Gao E, Cheng H, Wu G, et al. Branched chain amino acids exacerbate myocardial ischemia\/reperfusion vulnerability via enhancing GCN2\/ATF6\/PPAR-alpha pathway-dependent fatty acid oxidation. Theranostics. 2020;10(12):5623\u201340. https:\/\/doi.org\/10.7150\/thno.44836.","journal-title":"Theranostics"},{"issue":"1","key":"19_CR92","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1038\/s41467-018-05362-7","volume":"9","author":"D Shao","year":"2018","unstructured":"Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, et al. Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nat Commun. 2018;9(1):2935. https:\/\/doi.org\/10.1038\/s41467-018-05362-7.","journal-title":"Nat Commun"},{"issue":"5","key":"19_CR93","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11886-020-01282-5","volume":"22","author":"AC Cardoso","year":"2020","unstructured":"Cardoso AC, Pereira AHM, Sadek HA. Mechanisms of neonatal heart regeneration. Curr Cardiol Rep. 2020b;22(5):33. https:\/\/doi.org\/10.1007\/s11886-020-01282-5.","journal-title":"Curr Cardiol Rep"},{"issue":"3","key":"19_CR94","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","volume":"118","author":"AR Pinto","year":"2016","unstructured":"Pinto AR, Ilinykh A, Ivey MJ, Kuwabara JT, D'Antoni ML, Debuque R, et al. Revisiting cardiac cellular composition. Circ Res. 2016;118(3):400\u20139. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.307778.","journal-title":"Circ Res"},{"issue":"3","key":"19_CR95","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154(3):651\u201363. https:\/\/doi.org\/10.1016\/j.cell.2013.06.037.","journal-title":"Cell"},{"key":"19_CR96","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.yjmcc.2017.09.007","volume":"112","author":"X He","year":"2017","unstructured":"He X, Zeng H, Chen ST, Roman RJ, Aschner JL, Didion S, Chen JX. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104\u201313. https:\/\/doi.org\/10.1016\/j.yjmcc.2017.09.007.","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"19_CR97","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","volume":"31","author":"J Zhang","year":"2020","unstructured":"Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni-Barrera R, Masschelein E, et al. Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization. Cell Metab. 2020;31(6):1136\u20131153 e1137. https:\/\/doi.org\/10.1016\/j.cmet.2020.05.004.","journal-title":"Cell Metab"},{"issue":"8","key":"19_CR98","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","volume":"14","author":"MD Tallquist","year":"2017","unstructured":"Tallquist MD, Molkentin JD. Redefining the identity of cardiac fibroblasts. Nat Rev Cardiol. 2017;14(8):484\u201391. https:\/\/doi.org\/10.1038\/nrcardio.2017.57.","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"19_CR99","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","volume":"118","author":"JG Travers","year":"2016","unstructured":"Travers JG, Kamal FA, Robbins J, Yutzey KE, Blaxall BC. Cardiac fibrosis: the fibroblast awakens. Circ Res. 2016;118(6):1021\u201340. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306565.","journal-title":"Circ Res"},{"issue":"3","key":"19_CR100","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","volume":"4","author":"C Humeres","year":"2019","unstructured":"Humeres C, Frangogiannis NG. Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci. 2019;4(3):449\u201367. https:\/\/doi.org\/10.1016\/j.jacbts.2019.02.006.","journal-title":"JACC Basic Transl Sci"},{"issue":"12","key":"19_CR101","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1161\/CIRCRESAHA.120.316443","volume":"126","author":"L Tian","year":"2020","unstructured":"Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, et al. Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: a pyruvate dehydrogenase kinase-dependent shift in mitochondrial metabolism promotes right ventricular fibrosis. Circ Res. 2020;126(12):1723\u201345. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.316443.","journal-title":"Circ Res"},{"issue":"1","key":"19_CR102","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.1038\/s41467-019-12103-x","volume":"10","author":"AA Lombardi","year":"2019","unstructured":"Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, et al. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019;10(1):4509. https:\/\/doi.org\/10.1038\/s41467-019-12103-x.","journal-title":"Nat Commun"},{"key":"19_CR103","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","volume":"191","author":"Y Ma","year":"2018","unstructured":"Ma Y, Mouton AJ, Lindsey ML. Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction. Transl Res. 2018;191:15\u201328. https:\/\/doi.org\/10.1016\/j.trsl.2017.10.001.","journal-title":"Transl Res"},{"issue":"3","key":"19_CR104","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","volume":"169","author":"M Hulsmans","year":"2017","unstructured":"Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, et al. Macrophages facilitate electrical conduction in the heart. Cell. 2017;169(3):510\u2013522.e520. https:\/\/doi.org\/10.1016\/j.cell.2017.03.050.","journal-title":"Cell"},{"issue":"1","key":"19_CR105","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","volume":"183","author":"JA Nicolas-Avila","year":"2020","unstructured":"Nicolas-Avila JA, Lechuga-Vieco AV, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago DJ, et al. A network of macrophages supports mitochondrial homeostasis in the heart. Cell. 2020;183(1):94\u2013109 e123. https:\/\/doi.org\/10.1016\/j.cell.2020.08.031.","journal-title":"Cell"},{"issue":"1","key":"19_CR106","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","volume":"110","author":"Y Ma","year":"2016","unstructured":"Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, et al. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016;110(1):51\u201361.","journal-title":"Cardiovasc Res"},{"key":"19_CR107","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","volume":"62","author":"X Yan","year":"2013","unstructured":"Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, et al. Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. J Mol Cell Cardiol. 2013;62:24\u201335. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.04.023.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"19_CR108","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/eurheartj\/ehw002","volume":"38","author":"M Horckmans","year":"2017","unstructured":"Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2017;38(3):187\u201397. https:\/\/doi.org\/10.1093\/eurheartj\/ehw002.","journal-title":"Eur Heart J"},{"issue":"3","key":"19_CR109","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"AB Aurora","year":"2014","unstructured":"Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, et al. Macrophages are required for neonatal heart regeneration. J Clin Invest. 2014;124(3):1382\u201392. https:\/\/doi.org\/10.1172\/JCI72181.","journal-title":"J Clin Invest"},{"key":"19_CR110","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","volume":"10","author":"A Viola","year":"2019","unstructured":"Viola A, Munari F, Sanchez-Rodriguez R, Scolaro T, Castegna A. The metabolic signature of macrophage responses. Front Immunol. 2019;10:1462. https:\/\/doi.org\/10.3389\/fimmu.2019.01462.","journal-title":"Front Immunol"},{"issue":"4","key":"19_CR111","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.4049\/jimmunol.170.4.1964","volume":"170","author":"G Fossati","year":"2003","unstructured":"Fossati G, Moulding DA, Spiller DG, Moots RJ, White MR, Edwards SW. The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J Immunol. 2003;170(4):1964\u201372. https:\/\/doi.org\/10.4049\/jimmunol.170.4.1964.","journal-title":"J Immunol"},{"issue":"5","key":"19_CR112","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1159\/000491464","volume":"47","author":"A Tanimura","year":"2018","unstructured":"Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T. Mitochondrial activity and unfolded protein response are required for neutrophil differentiation. Cell Physiol Biochem. 2018;47(5):1936\u201350. https:\/\/doi.org\/10.1159\/000491464.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"19_CR113","doi-asserted-by":"publisher","first-page":"18801","DOI":"10.1038\/s41598-019-55295-4","volume":"9","author":"D Ahmed","year":"2019","unstructured":"Ahmed D, Roy D, Jaworski A, Edwards A, Abizaid A, Kumar A, et al. Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages. Sci Rep. 2019;9(1):18801. https:\/\/doi.org\/10.1038\/s41598-019-55295-4.","journal-title":"Sci Rep"},{"key":"19_CR114","doi-asserted-by":"publisher","first-page":"9029327","DOI":"10.1155\/2017\/9029327","volume":"2017","author":"T Wang","year":"2017","unstructured":"Wang T, Liu H, Lian G, Zhang SY, Wang X, Jiang C. HIF1alpha-induced glycolysis metabolism is essential to the activation of inflammatory macrophages. Mediat Inflamm. 2017;2017:9029327. https:\/\/doi.org\/10.1155\/2017\/9029327.","journal-title":"Mediat Inflamm"},{"key":"19_CR115","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.yjmcc.2019.08.002","volume":"135","author":"J Wu","year":"2019","unstructured":"Wu J, Sun P, Chen Q, Sun Y, Shi M, Mang G, et al. Metabolic reprogramming orchestrates CD4(+) T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated cardiomyopathy mice. J Mol Cell Cardiol. 2019;135:134\u201348. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.08.002.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"19_CR116","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","volume":"115","author":"J Weirather","year":"2014","unstructured":"Weirather J, Hofmann UD, Beyersdorf N, Ramos GC, Vogel B, Frey A, et al. Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte\/macrophage differentiation. Circ Res. 2014;115(1):55\u201367. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.303895.","journal-title":"Circ Res"},{"issue":"5","key":"19_CR117","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","volume":"146","author":"EV Dang","year":"2011","unstructured":"Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146(5):772\u201384. https:\/\/doi.org\/10.1016\/j.cell.2011.07.033.","journal-title":"Cell"},{"issue":"10","key":"19_CR118","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1172\/JCI84431","volume":"126","author":"SE Corcoran","year":"2016","unstructured":"Corcoran SE, O\u2019Neill LA. HIF1alpha and metabolic reprogramming in inflammation. J Clin Invest. 2016;126(10):3699\u2013707. https:\/\/doi.org\/10.1172\/JCI84431.","journal-title":"J Clin Invest"},{"key":"19_CR119","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.yjmcc.2021.05.008","volume":"158","author":"AJ Mouton","year":"2021","unstructured":"Mouton AJ, Flynn ER, Moak SP, Aitken NM, Omoto ACM, Li X, et al. Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism. J Mol Cell Cardiol. 2021;158:38\u201348. https:\/\/doi.org\/10.1016\/j.yjmcc.2021.05.008.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"19_CR120","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2012.01.017","volume":"15","author":"H Ashrafian","year":"2012","unstructured":"Ashrafian H, Czibik G, Bellahcene M, Aksentijevic D, Smith AC, Mitchell SJ, et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab. 2012;15(3):361\u201371. https:\/\/doi.org\/10.1016\/j.cmet.2012.01.017.","journal-title":"Cell Metab"},{"issue":"1","key":"19_CR121","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cell.2013.03.004","volume":"153","author":"WG Kaelin Jr","year":"2013","unstructured":"Kaelin WG Jr, McKnight SL. Influence of metabolism on epigenetics and disease. Cell. 2013;153(1):56\u201369. https:\/\/doi.org\/10.1016\/j.cell.2013.03.004.","journal-title":"Cell"},{"key":"19_CR122","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/296167","volume":"2015","author":"YF Her","year":"2015","unstructured":"Her YF, Maher LJ 3rd. Succinate dehydrogenase loss in familial Paraganglioma: biochemistry, genetics, and epigenetics. Int J Endocrinol. 2015;2015:296167. https:\/\/doi.org\/10.1155\/2015\/296167.","journal-title":"Int J Endocrinol"},{"issue":"6","key":"19_CR123","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","volume":"23","author":"E Letouze","year":"2013","unstructured":"Letouze E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, et al. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell. 2013;23(6):739\u201352. https:\/\/doi.org\/10.1016\/j.ccr.2013.04.018.","journal-title":"Cancer Cell"},{"issue":"2","key":"19_CR124","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","volume":"138","author":"K Bersell","year":"2009","unstructured":"Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138(2):257\u201370. https:\/\/doi.org\/10.1016\/j.cell.2009.04.060.","journal-title":"Cell"},{"issue":"9","key":"19_CR125","doi-asserted-by":"publisher","first-page":"E782","DOI":"10.1152\/ajpendo.00259.2015","volume":"310","author":"L Pentassuglia","year":"2016","unstructured":"Pentassuglia L, Heim P, Lebboukh S, Morandi C, Xu L, Brink M. Neuregulin-1beta promotes glucose uptake via PI3K\/Akt in neonatal rat cardiomyocytes. Am J Physiol Endocrinol Metab. 2016;310(9):E782\u201394. https:\/\/doi.org\/10.1152\/ajpendo.00259.2015.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"19_CR126","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.devcel.2020.06.025","volume":"54","author":"C Ibar","year":"2020","unstructured":"Ibar C, Irvine KD. Integration of hippo-YAP signaling with metabolism. Dev Cell. 2020;54(2):256\u201367. https:\/\/doi.org\/10.1016\/j.devcel.2020.06.025.","journal-title":"Dev Cell"},{"issue":"6","key":"19_CR127","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/FJC.0000000000000736","volume":"74","author":"T Kashihara","year":"2019","unstructured":"Kashihara T, Sadoshima J. Role of YAP\/TAZ in energy metabolism in the heart. J Cardiovasc Pharmacol. 2019;74(6):483\u201390. https:\/\/doi.org\/10.1097\/FJC.0000000000000736.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"10","key":"19_CR128","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.15252\/embj.201490379","volume":"34","author":"E Enzo","year":"2015","unstructured":"Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, et al. Aerobic glycolysis tunes YAP\/TAZ transcriptional activity. EMBO J. 2015;34(10):1349\u201370. https:\/\/doi.org\/10.15252\/embj.201490379.","journal-title":"EMBO J"},{"issue":"11","key":"19_CR129","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1038\/s41556-020-00588-4","volume":"22","author":"A Aharonov","year":"2020","unstructured":"Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, et al. ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol. 2020;22(11):1346\u201356. https:\/\/doi.org\/10.1038\/s41556-020-00588-4.","journal-title":"Nat Cell Biol"}],"container-title":["Advances in Experimental Medicine and Biology","Congenital Heart Diseases: The Broken Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-44087-8_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:21:19Z","timestamp":1757103679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-44087-8_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031440861","9783031440878"],"references-count":129,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-44087-8_19","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"18 June 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}