{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:24:46Z","timestamp":1793856286036,"version":"4.6.1"},"publisher-location":"Cham","reference-count":42,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031454929","type":"print"},{"value":"9783031454936","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-3-031-45493-6_16","type":"book-chapter","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T03:03:04Z","timestamp":1718334184000},"page":"315-327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endogenous Opioids in the Homeostatic Regulation of Hunger, Satiety, and Hedonic Eating: Neurobiological Foundations"],"prefix":"10.1007","author":[{"given":"Marcela Rodriguez","family":"Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvana","family":"Stephano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"issue":"2","key":"16_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/npp.2017.133","volume":"43","author":"AD Abraham","year":"2018","unstructured":"Abraham, A. D., Fontaine, H. M., Song, A. J., Andrews, M. M., Baird, M. A., Kieffer, B. L., et al. (2018). \u03ba-Opioid receptor activation in dopamine neurons disrupts behavioral inhibition. Neuropsychopharmacology, 43(2), 362\u2013372. https:\/\/doi.org\/10.1038\/npp.2017.133","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"16_CR2","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1210\/en.2013-1251","volume":"154","author":"M \u00c1lvarez-Crespo","year":"2013","unstructured":"\u00c1lvarez-Crespo, M., Mart\u00ednez-S\u00e1nchez, N., Ru\u00edz-Pino, F., Garcia-Lavandeira, M., Alvarez, C. V., Tena-Sempere, M., et al. (2013). The orexigenic effect of orexin-A revisited: Dependence of an intact growth hormone axis. Endocrinology, 154(10), 3589\u20133598. https:\/\/doi.org\/10.1210\/en.2013-1251","journal-title":"Endocrinology"},{"issue":"1","key":"16_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.coph.2008.12.01","volume":"9","author":"KC Berridge","year":"2009","unstructured":"Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009). Dissecting components of reward: \u2018Liking\u2019, \u2018wanting\u2019, and learning. Current Opinion in Pharmacology, 9(1), 65\u201373. https:\/\/doi.org\/10.1016\/j.coph.2008.12.01","journal-title":"Current Opinion in Pharmacology"},{"key":"16_CR03","doi-asserted-by":"crossref","unstructured":"Berthoud, H. R. (2002). Multiple neural systems controlling food intake and body weight. Neuroscience & Biobehavioral Reviews, 26(4), 393\u2013428.","DOI":"10.1016\/S0149-7634(02)00014-3"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fncir.2019.00078","volume":"13","author":"C Bouarab","year":"2019","unstructured":"Bouarab, C., Thompson, B., & Polter, A. M. (2019). VTA GABA neurons at the interface of stress and reward. Frontiers in Neural Circuits, 13, 78. https:\/\/doi.org\/10.3389\/fncir.2019.00078","journal-title":"Frontiers in Neural Circuits"},{"issue":"4","key":"16_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.biopsych.2014.07.033","volume":"77","author":"PCS Chung","year":"2015","unstructured":"Chung, P. C. S., Keyworth, H. L., Martin-Garcia, E., Charbogne, P., Darcq, E., Bailey, A., et al. (2015). A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Biological Psychiatry, 77(4), 404\u2013415. https:\/\/doi.org\/10.1016\/j.biopsych.2014.07.033","journal-title":"Biological Psychiatry"},{"key":"16_CR04","doi-asserted-by":"crossref","unstructured":"Cooper, S. J., Jackson, A., & Kirkham, T. C. (1985). Endorphins and food intake: kappa opioid receptor agonists and hyperphagia. Pharmacology Biochemistry and Behavior, 23(5), 889\u2013901.","DOI":"10.1016\/0091-3057(85)90088-7"},{"issue":"3","key":"16_CR6","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/sj.npp.1301430","volume":"33","author":"P Cottone","year":"2008","unstructured":"Cottone, P., Sabino, V., Steardo, L., & Zorrilla, E. P. (2008). Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology, 33(3), 524\u2013535. https:\/\/doi.org\/10.1038\/sj.npp.1301430","journal-title":"Neuropsychopharmacology"},{"key":"16_CR006","doi-asserted-by":"crossref","unstructured":"Crespo, C., Cachero, A., Jim\u00e9nez, L., Barrios, V., & Ferreiro, E. (2014). Peptides and food intake. Frontiers in Endocrinology, 5, 1\u201313.","DOI":"10.3389\/fendo.2014.00058"},{"key":"16_CR06","doi-asserted-by":"crossref","unstructured":"Czyzyk, T. A., Nogueiras, R., Lockwood, J. F., McKenzie, J. H., Coskun, T., Pintar, J. E., et al. (2010). kappa-Opioid receptors control the metabolic response to a high-energy diet in mice. The FASEB Journal, 24(4), 1151\u20131159.","DOI":"10.1096\/fj.09-143610"},{"issue":"8","key":"16_CR7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41583-018-0028-x","volume":"19","author":"E Darcq","year":"2018","unstructured":"Darcq, E., & Kieffer, B. L. (2018). Opioid receptors: Drivers to addiction? Nature Reviews Neuroscience, 19(8), 499\u2013514. https:\/\/doi.org\/10.1038\/s41583-018-0028-x","journal-title":"Nature Reviews Neuroscience"},{"issue":"2","key":"16_CR8","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00429-014-0717-9","volume":"220","author":"E Erbs","year":"2015","unstructured":"Erbs, E., Faget, L., Scherrer, G., Matifas, A., Filliol, D., Vonesch, J. L., et al. (2015). A mu\u2013delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Structure and Function, 220(2), 677\u2013702. https:\/\/doi.org\/10.1007\/s00429-014-0717-9","journal-title":"Brain Structure and Function"},{"issue":"31","key":"16_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2013.00031","volume":"7","author":"WJ Gao","year":"2013","unstructured":"Gao, W. J., & Snyder, M. A. (2013). NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Frontiers in Cellular Neuroscience, 7(31), 1\u201312. https:\/\/doi.org\/10.3389\/fncel.2013.00031","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"16_CR010","doi-asserted-by":"crossref","unstructured":"Gosnell, B. A., Romsos, D. R., Morley, J. E., Levine, A. S. (1985). Opiates and medial hypothalamic knife cuts cause hyperphagia through direct mechanisms. Behavioral Neuroscience, 99(6):1181\u20131191.","DOI":"10.1037\/\/0735-7044.99.6.1181"},{"issue":"2","key":"16_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0091-3057(90)90322-9","volume":"37","author":"BA Gosnell","year":"1990","unstructured":"Gosnell, B. A., Krahn, D. D., & Majchrzak, M. J. (1990). The effects of morphine on diet selection are dependent upon baseline diet preferences. Pharmacology Biochemistry and Behavior, 37(2), 207\u2013212. https:\/\/doi.org\/10.1016\/0091-3057(90)90322-9","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"4","key":"16_CR11","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1097\/HJH.0000000000000123","volume":"32","author":"G Grassi","year":"2014","unstructured":"Grassi, G. (2014). Leptin, the sympathetic nervous system and blood pressure: The tale is still without an end. Journal of Hypertension, 32(4), 738\u2013739. https:\/\/doi.org\/10.1097\/HJH.0000000000000123","journal-title":"Journal of Hypertension"},{"key":"16_CR12","volume-title":"Guyton and Hall textbook of medical physiology","author":"JE Hall","year":"2011","unstructured":"Hall, J. E. (2011). Guyton and Hall textbook of medical physiology (12th ed.). Elsevier Saunders.","edition":"12"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.physbeh.2013.07.004","volume":"120","author":"RB Harris","year":"2013","unstructured":"Harris, R. B. (2013). Evidence that leptin-induced weight loss requires activation of both forebrain and hindbrain receptors. Physiology & Behavior, 120, 83\u201392. https:\/\/doi.org\/10.1016\/j.physbeh.2013.07.004","journal-title":"Physiology & Behavior"},{"issue":"18","key":"16_CR14","doi-asserted-by":"publisher","first-page":"8251","DOI":"10.1523\/jneurosci.22-18-08251.2002","volume":"22","author":"MD Hayward","year":"2002","unstructured":"Hayward, M. D., Pintar, J. E., & Low, M. J. (2002). Selective reward deficit in mice lacking \u03b2-endorphin and enkephalin. Journal of Neuroscience, 22(18), 8251\u20138258. https:\/\/doi.org\/10.1523\/jneurosci.22-18-08251.2002","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"16_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.tins.2013.01.002","volume":"36","author":"AW Johnson","year":"2013","unstructured":"Johnson, A. W. (2013). Eating beyond metabolic need: How environmental cues influence feeding behavior. Trends in Neurosciences, 36(2), 101\u2013109. https:\/\/doi.org\/10.1016\/j.tins.2013.01.002","journal-title":"Trends in Neurosciences"},{"key":"16_CR016","doi-asserted-by":"crossref","unstructured":"Katarzyna Pomorska, D., do-Rego, J., do-Rego, J., Zubrzycka, M., & Janecka, A. (2016). Opioid and cannabinoid system in food intake. Current Pharmaceutical Design, 22(10), 1361\u20131370.","DOI":"10.2174\/1381612822666160125114144"},{"issue":"11","key":"16_CR16","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nrn3105","volume":"12","author":"PJ Kenny","year":"2011","unstructured":"Kenny, P. J. (2011). Common cellular and molecular mechanisms in obesity and drug addiction. Nature Reviews Neuroscience, 12(11), 638\u2013651.","journal-title":"Nature Reviews Neuroscience"},{"issue":"3","key":"16_CR17","first-page":"293","volume":"54","author":"SJ Konturek","year":"2003","unstructured":"Konturek, S. J., Pepera, J., Zabielski, K., Konturek, P. C., Pawlik, T., Szlachcic, A., & Hahn, E. G. (2003). Brain-gut axis in pancreatic secretion and appetite control. Journal of Physiology and Pharmacology, 54(3), 293\u2013317.","journal-title":"Journal of Physiology and Pharmacology"},{"key":"16_CR017","doi-asserted-by":"crossref","unstructured":"Larsen, P. J., & Hunter, R. G. (2006). The role of CART in body weight homeostasis. Peptides, 27(8), 1981\u20131986.","DOI":"10.1016\/j.peptides.2005.11.027"},{"issue":"6","key":"16_CR18","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/brain\/121.6.1013","volume":"121","author":"MM Mesulam","year":"1998","unstructured":"Mesulam, M. M. (1998). From sensation to cognition. Brain: A Journal of Neurology, 121(6), 1013\u20131052. https:\/\/doi.org\/10.1093\/brain\/121.6.1013","journal-title":"Brain: A Journal of Neurology"},{"key":"16_CR018","unstructured":"Morley, J. E., Levine, A. S., Gosnell, B. A., Kneip, J., & Grace, M. (1983). The kappa opioid receptor, ingestive behaviors and the obese mouse (ob\/ob). Physiology & Behavior, 31(5), 603\u2013606."},{"issue":"7","key":"16_CR19","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1017\/S146114570900039X","volume":"12","author":"PJ Nathan","year":"2009","unstructured":"Nathan, P. J., & Bullmore, E. T. (2009). From taste hedonics to motivational drive: Central \u03bc-opioid receptors and binge-eating behaviour. International Journal of Neuropsychopharmacology, 12(7), 995\u20131008. https:\/\/doi.org\/10.1017\/S146114570900039X","journal-title":"International Journal of Neuropsychopharmacology"},{"issue":"2","key":"16_CR20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1159\/000338163","volume":"5","author":"R Nogueiras","year":"2012","unstructured":"Nogueiras, R., Romero-Pic\u00f3, A., Vazquez, M. J., Novelle, M. G., L\u00f3pez, M., & Di\u00e9guez, C. (2012). The opioid system and food intake: Homeostatic and hedonic mechanisms. Obesity Facts, 5(2), 196\u2013207. https:\/\/doi.org\/10.1159\/000338163","journal-title":"Obesity Facts"},{"issue":"1","key":"16_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/nu10010071","volume":"10","author":"MG Novelle","year":"2018","unstructured":"Novelle, M. G., & Di\u00e9guez, C. (2018). Food addiction and binge eating: Lessons learned from animal models. Nutrients, 10(1), 71. https:\/\/doi.org\/10.3390\/nu10010071","journal-title":"Nutrients"},{"issue":"3","key":"16_CR22","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5694\/j.1326-5377.2011.tb03242.x","volume":"195","author":"J Proietto","year":"2011","unstructured":"Proietto, J. (2011). Why is treating obesity so difficult? Justification for the role of bariatric surgery. Medical Journal of Australia, 195(3), 144\u2013146.","journal-title":"Medical Journal of Australia"},{"issue":"2","key":"16_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00213-013-3096-3097","volume":"229","author":"A Romero-Pic\u00f3","year":"2013","unstructured":"Romero-Pic\u00f3, A., Novelle, M. G., Folgueira, C., L\u00f3pez, M., Nogueiras, R., & Di\u00e9guez, C. (2013). Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin. Psychopharmacology, 229(2), 275\u2013283. https:\/\/doi.org\/10.1007\/s00213-013-3096-3097","journal-title":"Psychopharmacology"},{"issue":"7","key":"16_CR24","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/npp.2013.28","volume":"38","author":"A Romero-Pico","year":"2013","unstructured":"Romero-Pico, A., V\u00e1zquez, M. J., Gonz\u00e1lez-Touceda, D., Folgueira, C., Skibicka, K. P., Alvarez-Crespo, M., et al. (2013). Hypothalamic \u03ba-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology, 38(7), 1296\u20131307. https:\/\/doi.org\/10.1038\/npp.2013.28","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"16_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0896-6273(02)009698","volume":"36","author":"CB Saper","year":"2002","unstructured":"Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002). The need to feed: Homeostatic and hedonic control of eating. Neuron, 36(2), 199\u2013211. https:\/\/doi.org\/10.1016\/S0896-6273(02)009698","journal-title":"Neuron"},{"key":"16_CR019","doi-asserted-by":"crossref","unstructured":"Slochower, J., Kap\u0142an, S. P., & Mann, L. (1981). The effects of life stress and weight on mood and eating. Appetite, 2(2), 115\u2013125.","DOI":"10.1016\/S0195-6663(81)80005-0"},{"key":"16_CR26","doi-asserted-by":"publisher","unstructured":"Suzuki, K., Jayasena, C. N., & Bloom, S. R. (2012). Obesity and appetite control. Experimental Diabetes Research, 2012. https:\/\/doi.org\/10.1155\/2012\/824305","DOI":"10.1155\/2012\/824305"},{"issue":"2","key":"16_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.14740\/jocmr4066","volume":"12","author":"LP Valbrun","year":"2020","unstructured":"Valbrun, L. P., & Zvonarev, V. (2020). The opioid system and food intake: Use of opiate antagonists in treatment of binge eating disorder and abnormal eating behavior. Journal of Clinical Medicine Research, 12(2), 41. https:\/\/doi.org\/10.14740\/jocmr4066","journal-title":"Journal of Clinical Medicine Research"},{"issue":"1","key":"16_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tics.2010.11.001","volume":"15","author":"ND Volkow","year":"2011","unstructured":"Volkow, N. D., Wang, G. J., & Baler, R. D. (2011). Reward, dopamine and the control of food intake: Implications for obesity. Trends in Cognitive Sciences, 15(1), 37\u201346. https:\/\/doi.org\/10.1016\/j.tics.2010.11.001","journal-title":"Trends in Cognitive Sciences"},{"issue":"2","key":"16_CR29","doi-asserted-by":"publisher","first-page":"R367","DOI":"10.1152\/ajpregu.00726.2005","volume":"291","author":"N Vrang","year":"2006","unstructured":"Vrang, N., Madsen, A. N., Tang-Christensen, M., Hansen, G., & Larsen, P. J. (2006). PYY (3\u201336) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 291(2), R367\u2013R375. https:\/\/doi.org\/10.1152\/ajpregu.00726.2005","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"issue":"4","key":"16_CR30","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1210\/endo.141.4.7410","volume":"141","author":"DL Williams","year":"2000","unstructured":"Williams, D. L., Kaplan, J. M., & Grill, H. J. (2000). The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3\/4 receptor stimulation. Endocrinology, 141(4), 1332\u20131337. https:\/\/doi.org\/10.1210\/endo.141.4.7410","journal-title":"Endocrinology"},{"issue":"6","key":"16_CR31","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1210\/en.2013-2099","volume":"155","author":"SW Yau","year":"2014","unstructured":"Yau, S. W., Henry, B. A., Russo, V. C., McConell, G. K., Clarke, I. J., Werther, G. A., & Sabin, M. A. (2014). Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: Evidence from nonrodent models. Endocrinology, 155(6), 2133\u20132143. https:\/\/doi.org\/10.1210\/en.2013-2099","journal-title":"Endocrinology"},{"issue":"6","key":"16_CR32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4093\/dmj.2012.36.6.391","volume":"36","author":"JH Yu","year":"2012","unstructured":"Yu, J. H., & Kim, M. S. (2012). Molecular mechanisms of appetite regulation. Diabetes & Metabolism Journal, 36(6), 391. https:\/\/doi.org\/10.4093\/dmj.2012.36.6.391","journal-title":"Diabetes & Metabolism Journal"},{"issue":"1","key":"16_CR33","first-page":"13","volume":"58","author":"K Zwirska-Korczala","year":"2007","unstructured":"Zwirska-Korczala, K., Konturek, S., Sodowski, M., Wylezol, M., Kuka, D., Sowa, P., et al. (2007). Basal and postprandial plasma levels of Pyy, Ghrelin. Journal of Physiology and Pharmacology, 58(1), 13\u201335.","journal-title":"Journal of Physiology and Pharmacology"}],"container-title":["Advances in Neurobiology","Endogenous Opioids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-45493-6_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:34:45Z","timestamp":1793853285000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-031-45493-6_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031454929","9783031454936"],"references-count":42,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-45493-6_16","relation":{},"ISSN":["2190-5215","2190-5223"],"issn-type":[{"value":"2190-5215","type":"print"},{"value":"2190-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"15 June 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}