{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:37:25Z","timestamp":1789749445651,"version":"4.0.1"},"publisher-location":"Cham","reference-count":111,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031473302","type":"print"},{"value":"9783031473319","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-3-031-47331-9_1","type":"book-chapter","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:39:21Z","timestamp":1705495161000},"page":"1-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gastric Stem Cell Biology and Helicobacter pylori Infection"],"prefix":"10.1007","author":[{"given":"Jonas","family":"Wizenty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2022.101948","volume":"75","author":"M Adkins-Threats","year":"2022","unstructured":"Adkins-Threats M, Mills JC (2022) Cell plasticity in regeneration in the stomach and beyond. Curr Opin Genet Dev 75:101948. https:\/\/doi.org\/10.1016\/j.gde.2022.101948","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"1_CR2","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1038\/s41467-022-33165-4","volume":"13","author":"C Aguilar","year":"2022","unstructured":"Aguilar C, Pauzuolis M, Pompaiah M, Vafadarnejad E, Arampatzi P, Fischer M, Narres D, Neyazi M, Kayisoglu \u00d6, Sell T, Bl\u00fcthgen N, Morkel M, Wiegering A, Germer CT, Kircher S, Rosenwald A, Saliba AE, Bartfeld S (2022) Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis. Nat Commun 13(1):5878. https:\/\/doi.org\/10.1038\/s41467-022-33165-4","journal-title":"Nat Commun"},{"issue":"1","key":"1_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1053\/j.gastro.2010.06.047","volume":"140","author":"IC Arnold","year":"2011","unstructured":"Arnold IC, Lee JY, Amieva MR, Roers A, Flavell RA, Sparwasser T, M\u00fcller A (2011a) Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140(1):199\u2013209. https:\/\/doi.org\/10.1053\/j.gastro.2010.06.047","journal-title":"Gastroenterology"},{"issue":"4","key":"1_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","volume":"9","author":"K Arnold","year":"2011","unstructured":"Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K (2011b) Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317\u2013329. https:\/\/doi.org\/10.1016\/j.stem.2011.09.001","journal-title":"Cell Stem Cell"},{"key":"1_CR5","doi-asserted-by":"publisher","unstructured":"Backert S, Naumann M (2010) What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol 8(11):479\u2013486. https:\/\/doi.org\/10.1016\/j.tim.2010.08.003. Epub 2010 Sep 20","DOI":"10.1016\/j.tim.2010.08.003"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1478-811x-9-28","volume":"9","author":"S Backert","year":"2011","unstructured":"Backert S, Clyne M, Tegtmeyer N (2011) Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal 9:28. https:\/\/doi.org\/10.1186\/1478-811x-9-28","journal-title":"Cell Commun Signal"},{"issue":"1","key":"1_CR7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","volume":"6","author":"N Barker","year":"2010","unstructured":"Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H (2010) Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6(1):25\u201336. https:\/\/doi.org\/10.1016\/j.stem.2009.11.013","journal-title":"Cell Stem Cell"},{"issue":"7165","key":"1_CR8","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165):1003\u20131007. https:\/\/doi.org\/10.1038\/nature06196","journal-title":"Nature"},{"issue":"1","key":"1_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","volume":"148","author":"S Bartfeld","year":"2015","unstructured":"Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, Kujala P, Vries R, Peters PJ, Clevers H (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148(1):126-136.e126. https:\/\/doi.org\/10.1053\/j.gastro.2014.09.042","journal-title":"Gastroenterology"},{"key":"1_CR10","doi-asserted-by":"publisher","unstructured":"Bartfeld S, Koo BK (2017) Adult gastric stem cells and their niches. Wiley Interdiscip Rev Dev Biol 6(2). https:\/\/doi.org\/10.1002\/wdev.261","DOI":"10.1002\/wdev.261"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/340157","volume":"2011","author":"B Bauer","year":"2011","unstructured":"Bauer B, Meyer TF (2011) The human gastric pathogen Helicobacter pylori and its association with gastric cancer and ulcer disease. Ulcers 2011:1\u201323. https:\/\/doi.org\/10.1155\/2011\/340157","journal-title":"Ulcers"},{"issue":"1","key":"1_CR12","doi-asserted-by":"publisher","first-page":"5117","DOI":"10.1038\/s41467-020-18857-z","volume":"11","author":"M Bauer","year":"2020","unstructured":"Bauer M, Nascakova Z, Mihai AI, Cheng PF, Levesque MP, Lampart S, Hurwitz R, Pfannkuch L, Dobrovolna J, Jacobs M, Bartfeld S, Dohlman A, Shen X, Gall AA, Salama NR, T\u00f6pfer A, Weber A, Meyer TF, Janscak P, M\u00fcller A (2020) The ALPK1\/TIFA\/NF-\u03baB axis links a bacterial carcinogen to R-loop-induced replication stress. Nat Commun 11(1):5117. https:\/\/doi.org\/10.1038\/s41467-020-18857-z","journal-title":"Nat Commun"},{"key":"1_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314540","author":"F Boccellato","year":"2018","unstructured":"Boccellato F, Woelffling S, Imai-Matsushima A, Sanchez G, Goosmann C, Schmid M, Berger H, Morey P, Denecke C, Ordemann J, Meyer TF (2018) Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2017-314540","journal-title":"Gut"},{"issue":"6","key":"1_CR14","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1053\/j.gastro.2020.08.027","volume":"159","author":"KA Bockerstett","year":"2020","unstructured":"Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ (2020) Single-cell transcriptional analyses identify lineage-specific epithelial responses to inflammation and metaplastic development in the gastric corpus. Gastroenterology 159(6):2116-2129.e2114. https:\/\/doi.org\/10.1053\/j.gastro.2020.08.027","journal-title":"Gastroenterology"},{"issue":"3","key":"1_CR15","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1053\/j.gastro.2019.09.037","volume":"158","author":"J Burclaff","year":"2020","unstructured":"Burclaff J, Willet SG, S\u00e1enz JB, Mills JC (2020) Proliferation and differentiation of gastric mucous neck and chief cells during homeostasis and injury-induced metaplasia. Gastroenterology 158(3):598-609.e595. https:\/\/doi.org\/10.1053\/j.gastro.2019.09.037","journal-title":"Gastroenterology"},{"issue":"6","key":"1_CR16","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1136\/gutjnl-2021-325310","volume":"71","author":"B Caldwell","year":"2022","unstructured":"Caldwell B, Meyer AR, Weis JA, Engevik AC, Choi E (2022) Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa. Gut 71(6):1068\u20131077. https:\/\/doi.org\/10.1136\/gutjnl-2021-325310","journal-title":"Gut"},{"issue":"6","key":"1_CR17","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1053\/j.gastro.2022.01.046","volume":"162","author":"L Cao","year":"2022","unstructured":"Cao L, Zhu S, Lu H, Soutto M, Bhat N, Chen Z, Peng D, Lin J, Lu J, Li P, Zheng C, Huang C, El-Rifai W (2022) Helicobacter pylori-induced RASAL2 through activation of nuclear factor-\u03baB promotes gastric tumorigenesis via \u03b2-catenin signaling axis. Gastroenterology 162(6):1716-1731.e1717. https:\/\/doi.org\/10.1053\/j.gastro.2022.01.046","journal-title":"Gastroenterology"},{"issue":"5","key":"1_CR18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.stem.2020.01.020","volume":"26","author":"W Chang","year":"2020","unstructured":"Chang W, Wang H, Kim W, Liu Y, Deng H, Liu H, Jiang Z, Niu Z, Sheng W, N\u00e1poles OC, Sun Y, Xu J, Sepulveda A, Hayakawa Y, Bass AJ, Wang TC (2020) Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis. Cell Stem Cell 26(5):739-754.e738. https:\/\/doi.org\/10.1016\/j.stem.2020.01.020","journal-title":"Cell Stem Cell"},{"key":"1_CR19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.037","author":"Q Chen","year":"2023","unstructured":"Chen Q, Weng K, Lin M, Jiang M, Fang Y, Chung SSW, Huang X, Zhong Q, Liu Z, Huang Z, Lin J, Li P, El-Rifai W, Zaika A, Li H, Rustgi AK, Nakagawa H, Abrams JA, Wang TC, Lu C, Huang C, Que J (2023) SOX9 modulates the transformation of gastric stem cells through biased symmetric cell division. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2023.01.037","journal-title":"Gastroenterology"},{"issue":"4","key":"1_CR20","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1053\/j.gastro.2015.11.049","volume":"150","author":"E Choi","year":"2016","unstructured":"Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR (2016) Expression of activated ras in gastric chief cells of mice leads to the full spectrum of metaplastic lineage transitions. Gastroenterology 150(4):918-930.e913. https:\/\/doi.org\/10.1053\/j.gastro.2015.11.049","journal-title":"Gastroenterology"},{"issue":"9","key":"1_CR21","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1136\/gutjnl-2017-313874","volume":"67","author":"E Choi","year":"2018","unstructured":"Choi E, Lantz TL, Vlacich G, Keeley TM, Samuelson LC, Coffey RJ, Goldenring JR, Powell AE (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67(9):1595\u20131605. https:\/\/doi.org\/10.1136\/gutjnl-2017-313874","journal-title":"Gut"},{"key":"1_CR22","doi-asserted-by":"publisher","unstructured":"Collins KD, Hu S, Grasberger H, Kao JY, Ottemann KM (2018) Chemotaxis allows bacteria to overcome host-generated reactive oxygen species that constrain gland colonization. Infect Immun 86(5). https:\/\/doi.org\/10.1128\/iai.00878-17","DOI":"10.1128\/iai.00878-17"},{"key":"1_CR23","doi-asserted-by":"publisher","unstructured":"Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513 (7517):202\u2013209. https:\/\/doi.org\/10.1038\/nature13480","DOI":"10.1038\/nature13480"},{"issue":"1","key":"1_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","volume":"13","author":"P Correa","year":"2012","unstructured":"Correa P, Piazuelo MB (2012) The gastric precancerous cascade. J Dig Dis 13(1):2\u20139. https:\/\/doi.org\/10.1111\/j.1751-2980.2011.00550.x","journal-title":"J Dig Dis"},{"issue":"7360","key":"1_CR25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nature10337","volume":"476","author":"W de Lau","year":"2011","unstructured":"de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476(7360):293\u2013297. https:\/\/doi.org\/10.1038\/nature10337","journal-title":"Nature"},{"issue":"2","key":"1_CR26","doi-asserted-by":"publisher","first-page":"G133","DOI":"10.1152\/ajpgi.00325.2016","volume":"312","author":"ES Demitrack","year":"2017","unstructured":"Demitrack ES, Gifford GB, Keeley TM, Horita N, Todisco A, Turgeon DK, Siebel CW, Samuelson LC (2017) NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus. Am J Physiol Gastrointest Liver Physiol 312(2):G133-g144. https:\/\/doi.org\/10.1152\/ajpgi.00325.2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"12","key":"1_CR27","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/s41556-021-00793-9","volume":"23","author":"A Fatehullah","year":"2021","unstructured":"Fatehullah A, Terakado Y, Sagiraju S, Tan TL, Sheng T, Tan SH, Murakami K, Swathi Y, Ang N, Rajarethinam R, Ming T, Tan P, Lee B, Barker N (2021) A tumour-resident Lgr5(+) stem-cell-like pool drives the establishment and progression of advanced gastric cancers. Nat Cell Biol 23(12):1299\u20131313. https:\/\/doi.org\/10.1038\/s41556-021-00793-9","journal-title":"Nat Cell Biol"},{"key":"1_CR28","doi-asserted-by":"publisher","unstructured":"Fischer AS, M\u00fcllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M (2022) R-spondin\/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice. J Clin Invest 132(21). https:\/\/doi.org\/10.1172\/jci151363","DOI":"10.1172\/jci151363"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.3389\/fmicb.2020.01592","volume":"11","author":"W Fischer","year":"2020","unstructured":"Fischer W, Tegtmeyer N, Stingl K, Backert S (2020) Four chromosomal type IV secretion systems in Helicobacter pylori: composition structure and function. Front Microbiol 11:1592. https:\/\/doi.org\/10.3389\/fmicb.2020.01592","journal-title":"Front Microbiol"},{"issue":"5","key":"1_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000231","volume":"17","author":"C Fung","year":"2019","unstructured":"Fung C, Tan S, Nakajima M, Skoog EC, Camarillo-Guerrero LF, Klein JA, Lawley TD, Solnick JV, Fukami T, Amieva MR (2019) High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach. PLoS Biol 17(5):e3000231. https:\/\/doi.org\/10.1371\/journal.pbio.3000231","journal-title":"PLoS Biol"},{"issue":"6","key":"1_CR31","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1136\/gutjnl-2015-310811","volume":"66","author":"GB Gifford","year":"2017","unstructured":"Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC (2017) Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis. Gut 66(6):1001\u20131011. https:\/\/doi.org\/10.1136\/gutjnl-2015-310811","journal-title":"Gut"},{"issue":"3","key":"1_CR32","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.stem.2019.07.008","volume":"25","author":"S Han","year":"2019","unstructured":"Han S, Fink J, J\u00f6rg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK (2019) Defining the identity and dynamics of adult gastric isthmus stem cells. Cell Stem Cell 25(3):342-356.e347. https:\/\/doi.org\/10.1016\/j.stem.2019.07.008","journal-title":"Cell Stem Cell"},{"key":"1_CR33","doi-asserted-by":"publisher","unstructured":"Hartung ML, Gruber DC, Koch KN, Gr\u00fcter L, Rehrauer H, Tegtmeyer N, Backert S, M\u00fcller A (2015) H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-\u03baB target gene expression. Cell Rep 13(1):70\u201379. https:\/\/doi.org\/10.1016\/j.celrep.2015.08.074","DOI":"10.1016\/j.celrep.2015.08.074"},{"issue":"6","key":"1_CR34","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1053\/j.gastro.2020.01.046","volume":"158","author":"M Hata","year":"2020","unstructured":"Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Kurokawa K, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K (2020) GPR30-expressing gastric chief cells do not dedifferentiate but are eliminated via PDK-dependent cell competition during development of metaplasia. Gastroenterology 158(6):1650-1666.e1615. https:\/\/doi.org\/10.1053\/j.gastro.2020.01.046","journal-title":"Gastroenterology"},{"issue":"6","key":"1_CR35","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.ccell.2015.10.003","volume":"28","author":"Y Hayakawa","year":"2015","unstructured":"Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC (2015a) Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche. Cancer Cell 28(6):800\u2013814. https:\/\/doi.org\/10.1016\/j.ccell.2015.10.003","journal-title":"Cancer Cell"},{"issue":"4","key":"1_CR36","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1136\/gutjnl-2014-307190","volume":"64","author":"Y Hayakawa","year":"2015","unstructured":"Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC (2015b) CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut 64(4):544\u2013553. https:\/\/doi.org\/10.1136\/gutjnl-2014-307190","journal-title":"Gut"},{"issue":"3","key":"1_CR37","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jcmgh.2017.01.013","volume":"3","author":"Y Hayakawa","year":"2017","unstructured":"Hayakawa Y, Fox JG, Wang TC (2017a) The origins of gastric cancer from gastric stem cells: lessons from mouse models. Cell Mol Gastroenterol Hepatol 3(3):331\u2013338. https:\/\/doi.org\/10.1016\/j.jcmgh.2017.01.013","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"1_CR38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","volume":"31","author":"Y Hayakawa","year":"2017","unstructured":"Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC (2017b) Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. Cancer Cell 31(1):21\u201334. https:\/\/doi.org\/10.1016\/j.ccell.2016.11.005","journal-title":"Cancer Cell"},{"issue":"1","key":"1_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007468","volume":"15","author":"L Holokai","year":"2019","unstructured":"Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins JA, Sundaram N, Wroblewski LE, Peek RM Jr, Wang J, Helmrath M, Wells JM, Zavros Y (2019) Increased programmed death-ligand 1 is an early epithelial cell response to Helicobacter pylori infection. PLoS Pathog 15(1):e1007468. https:\/\/doi.org\/10.1371\/journal.ppat.1007468","journal-title":"PLoS Pathog"},{"issue":"1","key":"1_CR40","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jcmgh.2021.08.012","volume":"13","author":"N Horita","year":"2022","unstructured":"Horita N, Keeley TM, Hibdon ES, Delgado E, Lafkas D, Siebel CW, Samuelson LC (2022) Delta-like 1-expressing cells at the gland base promote proliferation of gastric antral stem cells in mouse. Cell Mol Gastroenterol Hepatol 13(1):275\u2013287. https:\/\/doi.org\/10.1016\/j.jcmgh.2021.08.012","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1_CR41","doi-asserted-by":"publisher","unstructured":"Howitt MR, Lee JY, Lertsethtakarn P, Vogelmann R, Joubert LM, Ottemann KM, Amieva MR (2011) ChePep controls Helicobacter pylori infection of the gastric glands and chemotaxis in the epsilonproteobacteria. MBio 2(4). https:\/\/doi.org\/10.1128\/mBio.00098-11","DOI":"10.1128\/mBio.00098-11"},{"issue":"5349","key":"1_CR42","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.279.5349.373","volume":"279","author":"D Ilver","year":"1998","unstructured":"Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, Berg DE, Covacci A, Engstrand L, Boren T (1998) Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 279(5349):373\u2013377. https:\/\/doi.org\/10.1126\/science.279.5349.373","journal-title":"Science"},{"issue":"6","key":"1_CR43","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","volume":"29","author":"S Imai","year":"2021","unstructured":"Imai S, Ooki T, Murata-Kamiya N, Komura D, Tahmina K, Wu W, Takahashi-Kanemitsu A, Knight CT, Kunita A, Suzuki N, Del Valle AA, Tsuboi M, Hata M, Hayakawa Y, Ohnishi N, Ueda K, Fukayama M, Ushiku T, Ishikawa S, Hatakeyama M (2021) Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis. Cell Host Microbe 29(6):941-958.e910. https:\/\/doi.org\/10.1016\/j.chom.2021.04.006","journal-title":"Cell Host Microbe"},{"key":"1_CR44","doi-asserted-by":"publisher","first-page":"16189","DOI":"10.1038\/nmicrobiol.2016.189","volume":"2","author":"A Javaheri","year":"2016","unstructured":"Javaheri A, Kruse T, Moonens K, Mej\u00edas-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, K\u00f6niger V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol 2:16189. https:\/\/doi.org\/10.1038\/nmicrobiol.2016.189","journal-title":"Nat Microbiol"},{"issue":"3","key":"1_CR45","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1053\/j.gastro.2021.05.058","volume":"161","author":"H Jeong","year":"2021","unstructured":"Jeong H, Lee B, Kim KH, Cho SY, Cho Y, Park J, Lee Y, Oh Y, Hwang BR, Jang AR, Park JH, Park JH, Jeong SH, Lee D, Lee YC, Lim KM, Goldenring JR, Nam KT (2021) WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the up-regulation of IL33 in response to injury. Gastroenterology 161(3):953-967.e915. https:\/\/doi.org\/10.1053\/j.gastro.2021.05.058","journal-title":"Gastroenterology"},{"key":"1_CR46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mib.2017.11.019","volume":"41","author":"KS Johnson","year":"2018","unstructured":"Johnson KS, Ottemann KM (2018) Colonization, localization, and inflammation: the roles of H. pylori chemotaxis in vivo. Curr Opin Microbiol 41:51\u201357. https:\/\/doi.org\/10.1016\/j.mib.2017.11.019","journal-title":"Curr Opin Microbiol"},{"key":"1_CR47","doi-asserted-by":"publisher","unstructured":"Kapalczynska M, Lin M, Maertzdorf J, Heuberger J, Muellerke S, Zuo X, Vidal R, Shureiqi I, Fischer AS, Sauer S, Berger H, Kidess E, Mollenkopf HJ, Tacke F, Meyer TF, Sigal M (2022) BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation. Nat Commun 13(1):1577. https:\/\/doi.org\/10.1038\/s41467-022-29176-w","DOI":"10.1038\/s41467-022-29176-w"},{"key":"1_CR48","doi-asserted-by":"publisher","unstructured":"Karam SM (1993) Dynamics of epithelial cells in the corpus of the mouse stomach IV bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat Rec 236(2):314\u2013332. https:\/\/doi.org\/10.1002\/ar.1092360205","DOI":"10.1002\/ar.1092360205"},{"key":"1_CR49","doi-asserted-by":"publisher","unstructured":"Karam SM, Leblond CP (1993) Dynamics of epithelial cells in the corpus of the mouse stomach I identification of proliferative cell types and pinpointing of the stem cell. Anat Rec 236(2):259\u2013279. https:\/\/doi.org\/10.1002\/ar.1092360202","DOI":"10.1002\/ar.1092360202"},{"issue":"22","key":"1_CR50","doi-asserted-by":"publisher","first-page":"16085","DOI":"10.1074\/jbc.M112.445551","volume":"288","author":"SS Khurana","year":"2013","unstructured":"Khurana SS, Riehl TE, Moore BD, Fassan M, Rugge M, Romero-Gallo J, Noto J, Peek RM Jr, Stenson WF, Mills JC (2013) The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem 288(22):16085\u201316097. https:\/\/doi.org\/10.1074\/jbc.M112.445551","journal-title":"J Biol Chem"},{"key":"1_CR51","doi-asserted-by":"publisher","unstructured":"Kidane D (2018) Molecular mechanisms of H. pylori-induced DNA double-strand breaks. Int J Mol Sci 19(10). https:\/\/doi.org\/10.3390\/ijms19102891","DOI":"10.3390\/ijms19102891"},{"issue":"1","key":"1_CR52","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41467-019-14058-5","volume":"11","author":"JE Kim","year":"2020","unstructured":"Kim JE, Fei L, Yin WC, Coquenlorge S, Rao-Bhatia A, Zhang X, Shi SSW, Lee JH, Hahn NA, Rizvi W, Kim KH, Sung HK, Hui CC, Guo G, Kim TH (2020) Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun 11(1):334. https:\/\/doi.org\/10.1038\/s41467-019-14058-5","journal-title":"Nat Commun"},{"issue":"5","key":"1_CR53","doi-asserted-by":"publisher","first-page":"G583","DOI":"10.1152\/ajpgi.00351.2017","volume":"314","author":"H Kinoshita","year":"2018","unstructured":"Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K (2018) Mature gastric chief cells are not required for the development of metaplasia. Am J Physiol Gastrointest Liver Physiol 314(5):G583-g596. https:\/\/doi.org\/10.1152\/ajpgi.00351.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"1_CR54","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s10620-005-2709-3","volume":"50","author":"P Kitsanta","year":"2005","unstructured":"Kitsanta P, Triantafyllou K, Chatziargyriou M, Barbatzas C, Ladas SD (2005) Gastric mucosa epithelial cell kinetics are differentiated by anatomic site and Helicobacter pylori infection. Dig Dis Sci 50(6):1087\u20131091. https:\/\/doi.org\/10.1007\/s10620-005-2709-3","journal-title":"Dig Dis Sci"},{"issue":"24","key":"1_CR55","doi-asserted-by":"publisher","first-page":"7548","DOI":"10.1073\/pnas.1508113112","volume":"112","author":"BK Koo","year":"2015","unstructured":"Koo BK, van Es JH, van den Born M, Clevers H (2015) Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43; Znrf3-mutant neoplasia. Proc Natl Acad Sci USA 112(24):7548\u20137550. https:\/\/doi.org\/10.1073\/pnas.1508113112","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1_CR56","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/path.6050","volume":"259","author":"K Kumagai","year":"2023","unstructured":"Kumagai K, Shimizu T, Nikaido M, Hirano T, Kakiuchi N, Takeuchi Y, Minamiguchi S, Sakurai T, Teramura M, Utsumi T, Hiramatsu Y, Nakanishi Y, Takai A, Miyamoto S, Ogawa S, Seno H (2023) On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma. J Pathol 259(4):362\u2013368. https:\/\/doi.org\/10.1002\/path.6050","journal-title":"J Pathol"},{"key":"1_CR57","doi-asserted-by":"publisher","unstructured":"Lee ER, Leblond CP (1985) Dynamic histology of the antral epithelium in the mouse stomach: IV ultrastructure and renewal of gland cells. Am J Anat 172(3):241\u2013259. https:\/\/doi.org\/10.1002\/aja.1001720306","DOI":"10.1002\/aja.1001720306"},{"issue":"3","key":"1_CR58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/aja.1001640302","volume":"164","author":"ER Lee","year":"1982","unstructured":"Lee ER, Trasler J, Dwivedi S, Leblond CP (1982) Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features. Am J Anat 164(3):187\u2013207. https:\/\/doi.org\/10.1002\/aja.1001640302","journal-title":"Am J Anat"},{"issue":"5","key":"1_CR59","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.stem.2022.04.001","volume":"29","author":"JH Lee","year":"2022","unstructured":"Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK (2022a) P57(Kip2) imposes the reserve stem cell state of gastric chief cells. Cell Stem Cell 29(5):826-839.e829. https:\/\/doi.org\/10.1016\/j.stem.2022.04.001","journal-title":"Cell Stem Cell"},{"issue":"1","key":"1_CR60","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jcmgh.2021.08.017","volume":"13","author":"SH Lee","year":"2022","unstructured":"Lee SH, Jang B, Min J, Contreras-Panta EW, Presentation KS, Delgado AG, Piazuelo MB, Choi E, Goldenring JR (2022b) Up-regulation of aquaporin 5 defines spasmolytic polypeptide-expressing metaplasia and progression to incomplete intestinal metaplasia. Cell Mol Gastroenterol Hepatol 13(1):199\u2013217. https:\/\/doi.org\/10.1016\/j.jcmgh.2021.08.017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1_CR61","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.04.038","author":"SH Lee","year":"2023","unstructured":"Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, Roland JT, Hong SH, Sohn Y, Krystofiak E, Jang B, Ferri L, Sangwan V, Ragoussis J, Camilleri-Bro\u00ebt S, Caruso J, Chen-Tanyolac C, Strasser M, Gascard P, Tlsty TD, Huang S, Choi E, Goldenring JR (2023) Apposition of fibroblasts with metaplastic gastric cells promotes dysplastic transition. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2023.04.038","journal-title":"Gastroenterology"},{"issue":"7","key":"1_CR62","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/ncb3541","volume":"19","author":"M Leushacke","year":"2017","unstructured":"Leushacke M, Tan SH, Wong A, Swathi Y, Hajamohideen A, Tan LT, Goh J, Wong E, Denil S, Murakami K, Barker N (2017) Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. Nat Cell Biol 19(7):774\u2013786. https:\/\/doi.org\/10.1038\/ncb3541","journal-title":"Nat Cell Biol"},{"issue":"4","key":"1_CR63","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1053\/j.gastro.2021.12.252","volume":"162","author":"D Liabeuf","year":"2022","unstructured":"Liabeuf D, Oshima M, Stange DE, Sigal M (2022) Stem cells, Helicobacter pylori, and mutational landscape: utility of preclinical models to understand carcinogenesis and to direct management of gastric cancer. Gastroenterology 162(4):1067\u20131087. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.252","journal-title":"Gastroenterology"},{"issue":"5581","key":"1_CR64","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/science.1069076","volume":"297","author":"J Mahdavi","year":"2002","unstructured":"Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, Altraja S, Wadstrom T, Kersulyte D, Berg DE, Dubois A, Petersson C, Magnusson KE, Norberg T, Lindh F, Lundskog BB, Arnqvist A, Hammarstrom L, Boren T (2002) Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297(5581):573\u2013578. https:\/\/doi.org\/10.1126\/science.1069076","journal-title":"Science"},{"issue":"10","key":"1_CR65","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1136\/gutjnl-2020-322779","volume":"70","author":"J Matsuo","year":"2021","unstructured":"Matsuo J, Douchi D, Myint K, Mon NN, Yamamura A, Kohu K, Heng DL, Chen S, Mawan NA, Nuttonmanit N, Li Y, Srivastava S, Ho SWT, Lee NYS, Lee HK, Adachi M, Tamura A, Chen J, Yang H, Teh M, So JB, Yong WP, Tan P, Yeoh KG, Chuang LSH, Tsukita S, Ito Y (2021) Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. Gut 70(10):1833\u20131846. https:\/\/doi.org\/10.1136\/gutjnl-2020-322779","journal-title":"Gut"},{"issue":"1","key":"1_CR66","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1053\/j.gastro.2016.09.018","volume":"152","author":"J Matsuo","year":"2017","unstructured":"Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y (2017) Identification of stem cells in the epithelium of the stomach corpus and antrum of mice. Gastroenterology 152(1):218-231.e214. https:\/\/doi.org\/10.1053\/j.gastro.2016.09.018","journal-title":"Gastroenterology"},{"issue":"9","key":"1_CR67","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202152878","volume":"22","author":"G Maubach","year":"2021","unstructured":"Maubach G, Lim MCC, Sokolova O, Backert S, Meyer TF, Naumann M (2021) TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-\u03baB pathways. EMBO Rep 22(9):e52878. https:\/\/doi.org\/10.15252\/embr.202152878","journal-title":"EMBO Rep"},{"issue":"3","key":"1_CR68","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.molmed.2021.12.005","volume":"28","author":"G Maubach","year":"2022","unstructured":"Maubach G, Vieth M, Boccellato F, Naumann M (2022) Helicobacter pylori-induced NF-\u03baB: trailblazer for gastric pathophysiology. Trends Mol Med 28(3):210\u2013222. https:\/\/doi.org\/10.1016\/j.molmed.2021.12.005","journal-title":"Trends Mol Med"},{"issue":"1","key":"1_CR69","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41419-023-05568-8","volume":"14","author":"B Messina","year":"2023","unstructured":"Messina B, Lo Sardo F, Scalera S, Memeo L, Colarossi C, Mare M, Blandino G, Ciliberto G, Maugeri-Sacc\u00e0 M, Bon G (2023) Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression. Cell Death Dis 14(1):21. https:\/\/doi.org\/10.1038\/s41419-023-05568-8","journal-title":"Cell Death Dis"},{"issue":"2","key":"1_CR70","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.devcel.2020.07.005","volume":"55","author":"ZF Miao","year":"2020","unstructured":"Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN, Mills JC (2020) A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle. Dev Cell 55(2):178-194.e177. https:\/\/doi.org\/10.1016\/j.devcel.2020.07.005","journal-title":"Dev Cell"},{"key":"1_CR71","doi-asserted-by":"publisher","unstructured":"Mills JC, Sansom OJ (2015) Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal 8 (385):re8. https:\/\/doi.org\/10.1126\/scisignal.aaa7540","DOI":"10.1126\/scisignal.aaa7540"},{"issue":"2","key":"1_CR72","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1053\/j.gastro.2010.12.001","volume":"140","author":"JC Mills","year":"2011","unstructured":"Mills JC, Shivdasani RA (2011) Gastric epithelial stem cells. Gastroenterology 140(2):412\u2013424. https:\/\/doi.org\/10.1053\/j.gastro.2010.12.001","journal-title":"Gastroenterology"},{"key":"1_CR73","doi-asserted-by":"publisher","unstructured":"Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mej\u00edas-Luque R, Singer BB, Backert S, Gerhard M, Remaut H (2018) Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs. Embo J 37(13). https:\/\/doi.org\/10.15252\/embj.201798665","DOI":"10.15252\/embj.201798665"},{"issue":"4","key":"1_CR74","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.cell.2018.07.027","volume":"174","author":"K Nanki","year":"2018","unstructured":"Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T (2018) Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Cell 174(4):856-869.e817. https:\/\/doi.org\/10.1016\/j.cell.2018.07.027","journal-title":"Cell"},{"issue":"4","key":"1_CR75","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1136\/gutjnl-2020-320742","volume":"70","author":"H Nienh\u00fcser","year":"2021","unstructured":"Nienh\u00fcser H, Kim W, Malagola E, Ruan T, Valenti G, Middelhoff M, Bass A, Der CJ, Hayakawa Y, Wang TC (2021) Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice. Gut 70(4):654\u2013665. https:\/\/doi.org\/10.1136\/gutjnl-2020-320742","journal-title":"Gut"},{"issue":"1","key":"1_CR76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054344","volume":"8","author":"JM Noto","year":"2013","unstructured":"Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM Jr (2013) Helicobacter pylori promotes the expression of Kr\u00fcppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS ONE 8(1):e54344. https:\/\/doi.org\/10.1371\/journal.pone.0054344","journal-title":"PLoS ONE"},{"issue":"2","key":"1_CR77","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1053\/j.gastro.2007.11.058","volume":"134","author":"K Nozaki","year":"2008","unstructured":"Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR (2008) A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology 134(2):511\u2013522. https:\/\/doi.org\/10.1053\/j.gastro.2007.11.058","journal-title":"Gastroenterology"},{"issue":"5","key":"1_CR78","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1046\/j.1365-2958.1999.01300.x","volume":"31","author":"S Odenbreit","year":"1999","unstructured":"Odenbreit S, Till M, Hofreuter D, Faller G, Haas R (1999) Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue. Mol Microbiol 31(5):1537\u20131548. https:\/\/doi.org\/10.1046\/j.1365-2958.1999.01300.x","journal-title":"Mol Microbiol"},{"issue":"4","key":"1_CR79","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1128\/iai.70.4.1984-1990.2002","volume":"70","author":"KM Ottemann","year":"2002","unstructured":"Ottemann KM, Lowenthal AC (2002) Helicobacter pylori uses motility for initial colonization and to attain robust infection. Infect Immun 70(4):1984\u20131990. https:\/\/doi.org\/10.1128\/iai.70.4.1984-1990.2002","journal-title":"Infect Immun"},{"issue":"3","key":"1_CR80","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1136\/gut.40.3.297","volume":"40","author":"J Parsonnet","year":"1997","unstructured":"Parsonnet J, Friedman GD, Orentreich N, Vogelman H (1997) Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 40(3):297\u2013301. https:\/\/doi.org\/10.1136\/gut.40.3.297","journal-title":"Gut"},{"issue":"16","key":"1_CR81","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1093\/nar\/27.16.3325","volume":"27","author":"B Peck","year":"1999","unstructured":"Peck B, Ortkamp M, Diehl KD, Hundt E, Knapp B (1999) Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pylori. Nucleic Acids Res 27(16):3325\u20133333. https:\/\/doi.org\/10.1093\/nar\/27.16.3325","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"1_CR82","doi-asserted-by":"publisher","first-page":"9087","DOI":"10.1096\/fj.201802555R","volume":"33","author":"L Pfannkuch","year":"2019","unstructured":"Pfannkuch L, Hurwitz R, Traulsen J, Sigulla J, Poeschke M, Matzner L, Kosma P, Schmid M, Meyer TF (2019) ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori. Faseb J 33(8):9087\u20139099. https:\/\/doi.org\/10.1096\/fj.201802555R","journal-title":"Faseb J"},{"issue":"2","key":"1_CR83","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.stem.2019.07.002","volume":"25","author":"Y Post","year":"2019","unstructured":"Post Y, Clevers H (2019) Defining adult stem cell function at its simplest: the ability to replace lost cells through mitosis. Cell Stem Cell 25(2):174\u2013183. https:\/\/doi.org\/10.1016\/j.stem.2019.07.002","journal-title":"Cell Stem Cell"},{"key":"1_CR84","doi-asserted-by":"publisher","first-page":"13824","DOI":"10.1038\/ncomms13824","volume":"8","author":"Z Qi","year":"2017","unstructured":"Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ, Chen YG (2017) BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes. Nat Commun 8:13824. https:\/\/doi.org\/10.1038\/ncomms13824","journal-title":"Nat Commun"},{"issue":"6","key":"1_CR85","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1053\/j.gastro.2010.08.003","volume":"139","author":"M Quante","year":"2010","unstructured":"Quante M, Marrache F, Goldenring JR, Wang TC (2010) TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology 139(6):2018-2027.e2012. https:\/\/doi.org\/10.1053\/j.gastro.2010.08.003","journal-title":"Gastroenterology"},{"issue":"4","key":"1_CR86","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1053\/j.gastro.2017.11.278","volume":"154","author":"MD Radyk","year":"2018","unstructured":"Radyk MD, Burclaff J, Willet SG, Mills JC (2018) Metaplastic cells in the stomach arise, independently of stem cells, via dedifferentiation or transdifferentiation of chief cells. Gastroenterology 154(4):839-843.e832. https:\/\/doi.org\/10.1053\/j.gastro.2017.11.278","journal-title":"Gastroenterology"},{"issue":"67","key":"1_CR87","doi-asserted-by":"publisher","first-page":"111012","DOI":"10.18632\/oncotarget.22451","volume":"8","author":"K Sakitani","year":"2017","unstructured":"Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC (2017) CXCR4-expressing Mist1(+) progenitors in the gastric antrum contribute to gastric cancer development. Oncotarget 8(67):111012\u2013111025. https:\/\/doi.org\/10.18632\/oncotarget.22451","journal-title":"Oncotarget"},{"issue":"11","key":"1_CR88","doi-asserted-by":"publisher","first-page":"7085","DOI":"10.4049\/jimmunol.0803293","volume":"182","author":"A Sayi","year":"2009","unstructured":"Sayi A, Kohler E, Hitzler I, Arnold I, Schwendener R, Rehrauer H, M\u00fcller A (2009) The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk. J Immunol 182(11):7085\u20137101. https:\/\/doi.org\/10.4049\/jimmunol.0803293","journal-title":"J Immunol"},{"issue":"6","key":"1_CR89","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1053\/j.gastro.2019.09.026","volume":"157","author":"T Seidlitz","year":"2019","unstructured":"Seidlitz T, Chen YT, Uhlemann H, Sch\u00f6lch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE (2019) Mouse models of human gastric cancer subtypes with stomach-specific CreERT2-mediated pathway alterations. Gastroenterology 157(6):1599-1614.e1592. https:\/\/doi.org\/10.1053\/j.gastro.2019.09.026","journal-title":"Gastroenterology"},{"issue":"7","key":"1_CR90","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1002\/ijc.31571","volume":"143","author":"L Shao","year":"2018","unstructured":"Shao L, Li P, Ye J, Chen J, Han Y, Cai J, Lu X (2018) Risk of gastric cancer among patients with gastric intestinal metaplasia. Int J Cancer 143(7):1671\u20131677. https:\/\/doi.org\/10.1002\/ijc.31571","journal-title":"Int J Cancer"},{"issue":"2","key":"1_CR91","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jcmgh.2020.04.008","volume":"10","author":"W Sheng","year":"2020","unstructured":"Sheng W, Malagola E, Nienh\u00fcser H, Zhang Z, Kim W, Zamechek L, Sepulveda A, Hata M, Hayakawa Y, Zhao CM, Chen D, Wang TC (2020) Hypergastrinemia expands gastric ECL cells through CCK2R(+) progenitor cells via ERK activation. Cell Mol Gastroenterol Hepatol 10(2):434-449.e431. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.04.008","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"7668","key":"1_CR92","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature23642","volume":"548","author":"M Sigal","year":"2017","unstructured":"Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF (2017) Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature 548(7668):451\u2013455. https:\/\/doi.org\/10.1038\/nature23642","journal-title":"Nature"},{"issue":"7","key":"1_CR93","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41556-019-0339-9","volume":"21","author":"M Sigal","year":"2019","unstructured":"Sigal M, Reines MDM, Mullerke S, Fischer C, Kapalczynska M, Berger H, Bakker ERM, Mollenkopf HJ, Rothenberg ME, Wiedenmann B, Sauer S, Meyer TF (2019) R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach. Nat Cell Biol 21(7):812\u2013823. https:\/\/doi.org\/10.1038\/s41556-019-0339-9","journal-title":"Nat Cell Biol"},{"issue":"7","key":"1_CR94","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1053\/j.gastro.2015.02.049","volume":"148","author":"M Sigal","year":"2015","unstructured":"Sigal M, Rothenberg ME, Logan CY, Lee JY, Honaker RW, Cooper RL, Passarelli B, Camorlinga M, Bouley DM, Alvarez G, Nusse R, Torres J, Amieva MR (2015) Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands. Gastroenterology 148(7):1392-1404.e1321. https:\/\/doi.org\/10.1053\/j.gastro.2015.02.049","journal-title":"Gastroenterology"},{"issue":"2","key":"1_CR95","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cell.2013.09.008","volume":"155","author":"DE Stange","year":"2013","unstructured":"Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H (2013) Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155(2):357\u2013368. https:\/\/doi.org\/10.1016\/j.cell.2013.09.008","journal-title":"Cell"},{"issue":"5","key":"1_CR96","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1053\/j.gastro.2015.05.059","volume":"149","author":"P Tan","year":"2015","unstructured":"Tan P, Yeoh KG (2015) Genetics and molecular pathogenesis of gastric adenocarcinoma. Gastroenterology 149(5):1153-1162.e1153. https:\/\/doi.org\/10.1053\/j.gastro.2015.05.059","journal-title":"Gastroenterology"},{"issue":"7795","key":"1_CR97","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41586-020-1973-x","volume":"578","author":"SH Tan","year":"2020","unstructured":"Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, Wong E, Fatehullah A, Sheng T, Ho SWT, Grabsch HI, Srivastava S, Teh M, Denil S, Mustafah S, Tan P, Shabbir A, So J, Yeoh KG, Barker N (2020) AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature 578(7795):437\u2013443. https:\/\/doi.org\/10.1038\/s41586-020-1973-x","journal-title":"Nature"},{"key":"1_CR98","doi-asserted-by":"publisher","unstructured":"Teriyapirom I, Kim J, Lee H, Merker SR, Andersson-Rolf A, Jahn SR, Ada AM, Kim SM, Lim JY, Schm\u00e4che T, Wetterling N, Stegert S, Park JY, Cheong JH, Kim H, Stange DE, Koo BK (2023) Acquired epithelial WNT secretion drives niche independence of developing gastric cancer. bioRxiv:2023.2002.2024.529854. https:\/\/doi.org\/10.1101\/2023.02.24.529854","DOI":"10.1101\/2023.02.24.529854"},{"key":"1_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2021.101737","volume":"50\u201351","author":"J Traulsen","year":"2021","unstructured":"Traulsen J, Zagami C, Daddi AA, Boccellato F (2021) Molecular modelling of the gastric barrier response, from infection to carcinogenesis. Best Pract Res Clin Gastroenterol 50\u201351:101737. https:\/\/doi.org\/10.1016\/j.bpg.2021.101737","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"1_CR100","doi-asserted-by":"publisher","unstructured":"Uehara T, Ma D, Yao Y, Lynch JP, Morales K, Ziober A, Feldman M, Ota H, Sepulveda AR (2013) H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. Dig Dis Sci 58(1):140\u2013149. https:\/\/doi.org\/10.1007\/s10620-012-2360-8","DOI":"10.1007\/s10620-012-2360-8"},{"key":"1_CR101","doi-asserted-by":"publisher","unstructured":"Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC (2018) Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. Embo J 37(7). https:\/\/doi.org\/10.15252\/embj.201798311","DOI":"10.15252\/embj.201798311"},{"issue":"13","key":"1_CR102","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109996","volume":"41","author":"J Wizenty","year":"2022","unstructured":"Wizenty J, M\u00fcllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M (2022) Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis. Embo J 41(13):e109996. https:\/\/doi.org\/10.15252\/embj.2021109996","journal-title":"Embo J"},{"issue":"2","key":"1_CR103","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1053\/j.gastro.2021.04.062","volume":"161","author":"S W\u00f6lffling","year":"2021","unstructured":"W\u00f6lffling S, Daddi AA, Imai-Matsushima A, Fritsche K, Goosmann C, Traulsen J, Lisle R, Schmid M, Reines-Benassar MDM, Pfannkuch L, Brinkmann V, Bornschein J, Malfertheiner P, Ordemann J, Link A, Meyer TF, Boccellato F (2021) EGF and BMPs govern differentiation and patterning in human gastric glands. Gastroenterology 161(2):623-636.e616. https:\/\/doi.org\/10.1053\/j.gastro.2021.04.062","journal-title":"Gastroenterology"},{"issue":"1\u20132","key":"1_CR104","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cell.2014.11.042","volume":"160","author":"DL Worthley","year":"2015","unstructured":"Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC (2015) Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 160(1\u20132):269\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2014.11.042","journal-title":"Cell"},{"issue":"13","key":"1_CR105","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.1073\/pnas.130079797","volume":"97","author":"Y Yamaoka","year":"2000","unstructured":"Yamaoka Y, Kwon DH, Graham DY (2000) A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc Natl Acad Sci USA 97(13):7533\u20137538. https:\/\/doi.org\/10.1073\/pnas.130079797","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7653","key":"1_CR106","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature22313","volume":"545","author":"KS Yan","year":"2017","unstructured":"Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ (2017) Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem-cell self-renewal. Nature 545(7653):238\u2013242. https:\/\/doi.org\/10.1038\/nature22313","journal-title":"Nature"},{"issue":"4","key":"1_CR107","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.jcmgh.2018.01.007","volume":"5","author":"W Ye","year":"2018","unstructured":"Ye W, Takabayashi H, Yang Y, Mao M, Hibdon ES, Samuelson LC, Eaton KA, Todisco A (2018) Regulation of gastric Lgr5+ve cell homeostasis by bone morphogenetic protein (BMP) signaling and inflammatory stimuli. Cell Mol Gastroenterol Hepatol 5(4):523\u2013538. https:\/\/doi.org\/10.1016\/j.jcmgh.2018.01.007","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"1_CR108","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/path.5244","volume":"248","author":"T Yoshioka","year":"2019","unstructured":"Yoshioka T, Fukuda A, Araki O, Ogawa S, Hanyu Y, Matsumoto Y, Yamaga Y, Nakanishi Y, Kawada K, Sakai Y, Chiba T, Seno H (2019) Bmi1 marks gastric stem cells located in the isthmus in mice. J Pathol 248(2):179\u2013190. https:\/\/doi.org\/10.1002\/path.5244","journal-title":"J Pathol"},{"issue":"10","key":"1_CR109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007359","volume":"14","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Busch B, Jim\u00e9nez-Soto LF, Ishikawa-Ankerhold H, Massberg S, Terradot L, Fischer W, Haas R (2018) Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation. PLoS Pathog 14(10):e1007359. https:\/\/doi.org\/10.1371\/journal.ppat.1007359","journal-title":"PLoS Pathog"},{"issue":"7721","key":"1_CR110","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s41586-018-0433-3","volume":"561","author":"P Zhou","year":"2018","unstructured":"Zhou P, She Y, Dong N, Li P, He H, Borio A, Wu Q, Lu S, Ding X, Cao Y, Xu Y, Gao W, Dong M, Ding J, Wang DC, Zamyatina A, Shao F (2018) Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature 561(7721):122\u2013126. https:\/\/doi.org\/10.1038\/s41586-018-0433-3","journal-title":"Nature"},{"key":"1_CR111","doi-asserted-by":"publisher","unstructured":"Zhu S, Al-Mathkour M, Cao L, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Hu T, McDonald OG, Zaika A, El-Rifai W (2023) CDK1 bridges NF-\u03baB and \u03b2-catenin signaling in response to H.\u00a0pylori infection in gastric tumorigenesis. Cell Rep 42(1):112005. https:\/\/doi.org\/10.1016\/j.celrep.2023.112005","DOI":"10.1016\/j.celrep.2023.112005"}],"container-title":["Current Topics in Microbiology and Immunology","Helicobacter pylori and Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-47331-9_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:39:53Z","timestamp":1705495193000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-47331-9_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031473302","9783031473319"],"references-count":111,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-47331-9_1","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"18 January 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}