{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:01:12Z","timestamp":1786978872079,"version":"build-2736575974"},"publisher-location":"Cham","reference-count":41,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031585715","type":"print"},{"value":"9783031585722","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-3-031-58572-2_8","type":"book-chapter","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T18:02:13Z","timestamp":1722016933000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Probiotics in the Treatment of Inflammatory Bowel Diseases"],"prefix":"10.1007","author":[{"given":"Stefano","family":"Guandalini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"issue":"4","key":"8_CR1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.gtc.2017.08.003","volume":"46","author":"BP Abraham","year":"2017","unstructured":"Abraham BP, Quigley EMM (2017) Probiotics in inflammatory bowel disease. Gastroenterol Clin N Am 46(4):769\u2013782","journal-title":"Gastroenterol Clin N Am"},{"issue":"2","key":"8_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3920\/BM2017.0097","volume":"9","author":"J Alard","year":"2018","unstructured":"Alard J, Peucelle V, Boutillier D, Breton J, Kuylle S, Pot B, Holowacz S, Grangette C (2018) New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches. Benef Microbes 9(2):317\u2013331","journal-title":"Benef Microbes"},{"issue":"8","key":"8_CR3","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.cgh.2013.02.021","volume":"11","author":"A Bourreille","year":"2013","unstructured":"Bourreille A, Cadiot G, Le Dreau G, Laharie D, Beaugerie L, Dupas JL, Marteau P, Rampal P, Moyse D, Saleh A, Le Guern ME, Galmiche JP, F. S. Group (2013) Saccharomyces boulardii does not prevent relapse of Crohn\u2019s disease. Clin Gastroenterol Hepatol 11(8):982\u2013987","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"8_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/01.MIB.0000175905.00212.2c","volume":"11","author":"A Bousvaros","year":"2005","unstructured":"Bousvaros A, Guandalini S, Baldassano RN, Botelho C, Evans J, Ferry GD, Goldin B, Hartigan L, Kugathasan S, Levy J, Murray KF, Oliva-Hemker M, Rosh JR, Tolia V, Zholudev A, Vanderhoof JA, Hibberd PL (2005) A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn\u2019s disease. Inflamm Bowel Dis 11(9):833\u2013839","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"8_CR6","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1136\/gut.2005.078824","volume":"55","author":"MP Conte","year":"2006","unstructured":"Conte MP, Schippa S, Zamboni I, Penta M, Chiarini F, Seganti L, Osborn J, Falconieri P, Borrelli O, Cucchiara S (2006) Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease. Gut 55(12):1760\u20131767","journal-title":"Gut"},{"key":"8_CR7","doi-asserted-by":"crossref","unstructured":"Duricova D, Burisch J, Jess T, Gower-Rousseau C, Lakatos PL, E.-E. On Behalf of (2014) Age-related differences in presentation and course of inflammatory bowel disease: an update on the population-based literature. J Crohns Colitis","DOI":"10.1016\/j.crohns.2014.05.006"},{"issue":"3","key":"8_CR8","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/jcp.25911","volume":"233","author":"M Ganji-Arjenaki","year":"2018","unstructured":"Ganji-Arjenaki M, Rafieian-Kopaei M (2018) Probiotics are a good choice in remission of inflammatory bowel diseases: a meta analysis and systematic review. J Cell Physiol 233(3):2091\u20132103","journal-title":"J Cell Physiol"},{"key":"8_CR9","doi-asserted-by":"crossref","unstructured":"Gilliland A, Chan J, De Wolfe TJ, Yang H, Vallance BA (2023) Pathobionts in IBD: origins, underlying mechanisms, and implications for clinical care. Gastroenterology","DOI":"10.1053\/j.gastro.2023.09.019"},{"issue":"1","key":"8_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/MPG.0b013e31822d53e5","volume":"54","author":"T Gosiewski","year":"2012","unstructured":"Gosiewski T, Strus M, Fyderek K, Kowalska-Duplaga K, Wedrychowicz A, Jedynak-Wasowicz U, Sladek M, Pieczarkowski S, Adamski P, Heczko PB (2012) Horizontal distribution of the fecal microbiota in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 54(1):20\u201327","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7","key":"8_CR11","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1023\/A:1005588911207","volume":"45","author":"M Guslandi","year":"2000","unstructured":"Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn\u2019s disease. Dig Dis Sci 45(7):1462\u20131464","journal-title":"Dig Dis Sci"},{"issue":"9","key":"8_CR12","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1055\/s-2008-1027463","volume":"46","author":"J Henker","year":"2008","unstructured":"Henker J, Muller S, Laass MW, Schreiner A, Schulze J (2008) Probiotic Escherichia coli Nissle 1917 (EcN) for successful remission maintenance of ulcerative colitis in children and adolescents: an open-label pilot study. Z Gastroenterol 46(9):874\u2013875","journal-title":"Z Gastroenterol"},{"issue":"5","key":"8_CR13","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/ibd.20816","volume":"15","author":"HQ Huynh","year":"2009","unstructured":"Huynh HQ, deBruyn J, Guan L, Diaz H, Li M, Girgis S, Turner J, Fedorak R, Madsen K (2009) Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study. Inflamm Bowel Dis 15(5):760\u2013768","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"8_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11908-018-0627-8","volume":"20","author":"SR Jeon","year":"2018","unstructured":"Jeon SR, Chai J, Kim C, Lee CH (2018) Current evidence for the management of inflammatory bowel diseases using fecal microbiota transplantation. Curr Infect Dis Rep 20(8):21","journal-title":"Curr Infect Dis Rep"},{"issue":"3","key":"8_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/MPG.0b013e3182617c16","volume":"55","author":"R Kellermayer","year":"2012","unstructured":"Kellermayer R, Mir SA, Nagy-Szakal D, Cox SB, Dowd SE, Kaplan JL, Sun Y, Reddy S, Bronsky J, Winter HS (2012) Microbiota separation and C-reactive protein elevation in treatment-naive pediatric granulomatous Crohn disease. J Pediatr Gastroenterol Nutr 55(3):243\u2013250","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"8_CR16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mib.2018.07.003","volume":"44","author":"M Kriss","year":"2018","unstructured":"Kriss M, Hazleton KZ, Nusbacher NM, Martin CG, Lozupone CA (2018) Low diversity gut microbiota dysbiosis: drivers, functional implications and recovery. Curr Opin Microbiol 44:34\u201340","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"8_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s40168-019-0725-3","volume":"7","author":"A Lavelle","year":"2019","unstructured":"Lavelle A, Hoffmann TW, Pham HP, Langella P, Guedon E, Sokol H (2019) Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host. Microbiome 7(1):111","journal-title":"Microbiome"},{"issue":"2","key":"8_CR18","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1053\/j.gastro.2020.09.056","volume":"160","author":"M Lee","year":"2021","unstructured":"Lee M, Chang EB (2021) Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues. Gastroenterology 160(2):524\u2013537","journal-title":"Gastroenterology"},{"issue":"7","key":"8_CR19","first-page":"CD006634","volume":"7","author":"BN Limketkai","year":"2020","unstructured":"Limketkai BN, Akobeng AK, Gordon M, Adepoju AA (2020) Probiotics for induction of remission in Crohn\u2019s disease. Cochrane Database Syst Rev 7(7):CD006634","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"8_CR20","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","volume":"126","author":"EV Loftus Jr","year":"2004","unstructured":"Loftus EV Jr (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126(6):1504\u20131517","journal-title":"Gastroenterology"},{"issue":"2","key":"8_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3390\/nu3020245","volume":"3","author":"DR Mack","year":"2011","unstructured":"Mack DR (2011) Probiotics in inflammatory bowel diseases and associated conditions. Nutrients 3(2):245\u2013264","journal-title":"Nutrients"},{"issue":"1","key":"8_CR23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/apt.14384","volume":"47","author":"J McIlroy","year":"2018","unstructured":"McIlroy J, Ianiro G, Mukhopadhya I, Hansen R, Hold GL (2018) Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management. Aliment Pharmacol Ther 47(1):26\u201342","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"8_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/ajg.2008.118","volume":"104","author":"E Miele","year":"2009","unstructured":"Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A (2009) Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol 104(2):437\u2013443","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"8_CR25","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/MPG.0000000000001896","volume":"66","author":"E Miele","year":"2018","unstructured":"Miele E, Shamir R, Aloi M, Assa A, Braegger C, Bronsky J, de Ridder L, Escher JC, Hojsak I, Kolacek S, Koletzko S, Levine A, Lionetti P, Martinelli M, Ruemmele F, Russell RK, Boneh RS, van Limbergen J, Veereman G, Staiano A (2018) Nutrition in pediatric inflammatory bowel disease: a position paper on behalf of the Porto inflammatory bowel disease Group of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 66(4):687\u2013708","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"8_CR26","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1186\/gb-2012-13-9-r79","volume":"13","author":"XC Morgan","year":"2012","unstructured":"Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C (2012) Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 13(9):R79","journal-title":"Genome Biol"},{"issue":"10","key":"8_CR27","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","volume":"14","author":"J Ni","year":"2017","unstructured":"Ni J, Wu GD, Albenberg L, Tomov VT (2017) Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol 14(10):573\u2013584","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"8_CR28","doi-asserted-by":"crossref","unstructured":"Oligschlaeger Y, Yadati T, Houben T, Condello Olivan CM, Shiri-Sverdlov R (2019) Inflammatory bowel disease: a stressed \u201cGut\/Feeling\u201d. Cells 8(7)","DOI":"10.3390\/cells8070659"},{"issue":"3","key":"8_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1365-2036.2011.04939.x","volume":"35","author":"S Oliva","year":"2012","unstructured":"Oliva S, Di Nardo G, Ferrari F, Mallardo S, Rossi P, Patrizi G, Cucchiara S, Stronati L (2012) Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis. Aliment Pharmacol Ther 35(3):327\u2013334","journal-title":"Aliment Pharmacol Ther"},{"key":"8_CR30","doi-asserted-by":"crossref","unstructured":"Pesce M, Seguella L, Del Re A, Lu J, Palenca I, Corpetti C, Rurgo S, Sanseverino W, Sarnelli G, Esposito G (2022) Next-generation probiotics for inflammatory bowel disease. Int J Mol Sci 23(10)","DOI":"10.3390\/ijms23105466"},{"key":"8_CR31","doi-asserted-by":"crossref","unstructured":"Petersen AM, Mirsepasi H, Halkjaer SI, Mortensen EM, Nordgaard-Lassen I, Krogfelt KA (2014) Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: a double-blind randomized placebo controlled clinical trial. J Crohns Colitis","DOI":"10.1016\/S0016-5085(14)62142-9"},{"issue":"12","key":"8_CR32","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1080\/00365521.2016.1216587","volume":"51","author":"M Prosberg","year":"2016","unstructured":"Prosberg M, Bendtsen F, Vind I, Petersen AM, Gluud LL (2016) The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis. Scand J Gastroenterol 51(12):1407\u20131415","journal-title":"Scand J Gastroenterol"},{"key":"8_CR33","doi-asserted-by":"publisher","first-page":"733992","DOI":"10.3389\/fcimb.2022.733992","volume":"12","author":"P Qiu","year":"2022","unstructured":"Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y (2022) The gut microbiota in inflammatory bowel disease. Front Cell Infect Microbiol 12:733992","journal-title":"Front Cell Infect Microbiol"},{"key":"8_CR34","doi-asserted-by":"crossref","unstructured":"Reister M, Hoffmeier K, Krezdorn N, Rotter B, Liang C, Rund S, Dandekar T, Sonnenborn U, Oelschlaeger TA (2014) Complete genome sequence of the gram-negative probiotic Escherichia coli strain Nissle 1917. J Biotechnol","DOI":"10.1016\/j.jbiotec.2014.07.442"},{"issue":"4","key":"8_CR35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/MOG.0b013e328353e61e","volume":"28","author":"M Scharl","year":"2012","unstructured":"Scharl M, Rogler G (2012) Inflammatory bowel disease pathogenesis: what is new? Curr Opin Gastroenterol 28(4):301\u2013309","journal-title":"Curr Opin Gastroenterol"},{"key":"8_CR36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-230X-4-5","volume":"4","author":"M Schultz","year":"2004","unstructured":"Schultz M, Timmer A, Herfarth HH, Sartor RB, Vanderhoof JA, Rath HC (2004) Lactobacillus GG in inducing and maintaining remission of Crohn\u2019s disease. BMC Gastroenterol 4:5","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"8_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.MIB.0000437495.30052.be","volume":"20","author":"J Shen","year":"2014","unstructured":"Shen J, Zuo ZX, Mao AP (2014) Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn\u2019s disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis 20(1):21\u201335","journal-title":"Inflamm Bowel Dis"},{"issue":"7","key":"8_CR38","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/j.1365-2036.2010.04417.x","volume":"32","author":"H Steed","year":"2010","unstructured":"Steed H, Macfarlane GT, Blackett KL, Bahrami B, Reynolds N, Walsh SV, Cummings JH, Macfarlane S (2010) Clinical trial: the microbiological and immunological effects of synbiotic consumption\u2014a randomized double-blind placebo-controlled study in active Crohn\u2019s disease. Aliment Pharmacol Ther 32(7):872\u2013883","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"8_CR39","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/MPG.0000000000003633","volume":"76","author":"H Szajewska","year":"2023","unstructured":"Szajewska H, Berni Canani R, Domellof M, Guarino A, Hojsak I, Indrio F, Lo Vecchio A, Mihatsch WA, Mosca A, Orel R, Salvatore S, Shamir R, van den Akker CHP, van Goudoever JB, Vandenplas Y, Weizman Z, E. S. I. G. o. G. Microbiota and Modifications (2023) Probiotics for the management of pediatric gastrointestinal disorders: position paper of the ESPGHAN special interest group on gut microbiota and modifications. J Pediatr Gastroenterol Nutr 76(2):232\u2013247","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"8_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/MPG.0000000000002035","volume":"67","author":"D Turner","year":"2018","unstructured":"Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos K, Croft N, Navas-Lopez V, Wilson DC, Lawrence S, Russell RK (2018) Management of paediatric ulcerative colitis, part 1: ambulatory care-an evidence-based guideline from European Crohn's and colitis organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 67(2):257\u2013291","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"8_CR41","doi-asserted-by":"crossref","unstructured":"Vakadaris G, Stefanis C, Giorgi E, Brouvalis M, Voidarou CC, Kourkoutas Y, Tsigalou C, Bezirtzoglou E (2023) The role of probiotics in inducing and maintaining remission in Crohn\u2019s disease and ulcerative colitis: a systematic review of the literature. Biomedicines 11(2)","DOI":"10.3390\/biomedicines11020494"},{"key":"8_CR42","doi-asserted-by":"crossref","unstructured":"Vich Vila A, Imhann F, Collij V, Jankipersadsing SA, Gurry T, Mujagic Z, Kurilshikov A, Bonder MJ, Jiang X, Tigchelaar EF, Dekens J, Peters V, Voskuil MD, Visschedijk MC, van Dullemen HM, Keszthelyi D, Swertz MA, Franke L, Alberts R, Festen EAM, Dijkstra G, Masclee AAM, Hofker MH, Xavier RJ, Alm EJ, Fu J, Wijmenga C, Jonkers D, Zhernakova A, Weersma RK (2018) Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Sci Transl Med 10(472)","DOI":"10.1126\/scitranslmed.aap8914"},{"key":"8_CR43","doi-asserted-by":"crossref","unstructured":"Zhang T, Zhang J, Duan L (2023) The role of genetically engineered probiotics for treatment of inflammatory bowel disease: a systematic review. Nutrients 15(7)","DOI":"10.3390\/nu15071566"}],"container-title":["Advances in Experimental Medicine and Biology","Probiotics and Child Gastrointestinal Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-58572-2_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T05:05:37Z","timestamp":1729919137000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-58572-2_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031585715","9783031585722"],"references-count":41,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-58572-2_8","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"27 July 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}