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Twenty-four patients with total fractions of 96 measurements were measured to evaluate the dynamic spectral status of radiotherapy response. Dynamic responses from absorbance measurement were found to be associated with effects of induced radiation to skin and it linearly correlates to the dose given. Whereas significantly no response was found in ex vivo samples. A spectrometer was used in near infrared range between 650\u00a0nm and 1100\u00a0nm wavelength in absorbance mode. The absorbance spectral dynamics were measured using one light source-detector probe attached to the forehead in human patients and chicken samples to compare their responses to irradiation. The absorbance measurements of the forehead (skin) show absorbance increase throughout the spectra during irradiation in patients and confirmed with repeatability whereas in corresponding irradiation of ex vivo chicken samples, no absorbance changes were detected. 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