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Studies on robot-assisted lower-limb rehabilitation with a randomized controlled trial (RCT) design, participants with stroke, a comparison group with conventional training, and balance-related outcomes were included. Studies were assessed for Cochrane Risk of Bias 2 and quality of evidence. Meta-analysis and meta-regression were performed.<\/jats:p><jats:p>A total of 48 (RCT) with 1472 participants were included. The overall risk of bias in the included studies was unclear (n\u2009=\u200932), high (n\u2009=\u200915) or low (n\u2009=\u20091). Compared to conventional rehabilitation, robot-assisted lower-limb rehabilitation interventions were more effective for balance improvement (Hedges\u2019 g\u2009=\u20090.25, 95% CI: 0.10 0.41). In meta-regression, a relationship between the training effect was observed with the time since stroke, explaining 56% of the variance (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and with the ankle robots, explaining 16% of the variance (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). No serious adverse events related to robot-assisted training were reported.<\/jats:p><jats:p>Robot-assisted lower-limb rehabilitation may improve balance more than conventional training in people with stroke, especially in the acute stage. Robot-assisted lower-limb rehabilitation seems to be a safe rehabilitation method for patients with stroke. To strengthen the evidence, more high-quality RCTs with adequate sample sizes are needed.<\/jats:p>","DOI":"10.1007\/978-3-031-59091-7_7","type":"book-chapter","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T18:01:59Z","timestamp":1714845719000},"page":"101-116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Robot-Assisted Lower Limb Rehabilitation on Balance in People with Stroke: A Systematic Review, Meta-analysis, and Meta-regression"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6488-1168","authenticated-orcid":false,"given":"Riku","family":"Yli-Ikkel\u00e4","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-4697","authenticated-orcid":false,"given":"Aki","family":"Rintala","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9571-5143","authenticated-orcid":false,"given":"Anna","family":"K\u00f6yh\u00e4joki","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-3232","authenticated-orcid":false,"given":"Harto","family":"Hakonen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-0542","authenticated-orcid":false,"given":"Hilkka","family":"Korpi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-0772","authenticated-orcid":false,"given":"Mirjami","family":"Kantola","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-8795","authenticated-orcid":false,"given":"Sari","family":"Honkanen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-5594","authenticated-orcid":false,"given":"Outi","family":"Ilves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-4618","authenticated-orcid":false,"given":"Tuulikki","family":"Sj\u00f6gren","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-769X","authenticated-orcid":false,"given":"Juha","family":"Karvanen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-926X","authenticated-orcid":false,"given":"Eeva","family":"Aartolahti","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"7_CR1","unstructured":"World Health Organization. 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