{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:00:10Z","timestamp":1743141610237,"version":"3.40.3"},"publisher-location":"Cham","reference-count":88,"publisher":"Springer Nature Switzerland","isbn-type":[{"type":"print","value":"9783031612374"},{"type":"electronic","value":"9783031612381"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-3-031-61238-1_5","type":"book-chapter","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:03:06Z","timestamp":1724997786000},"page":"89-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathologic Features of Primary Pancreatic Malignancies"],"prefix":"10.1007","author":[{"given":"Tarek","family":"Abi-Saab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina A.","family":"Matkowskyj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"issue":"4","key":"5_CR1","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/s0002-9440(10)62563-1","volume":"160","author":"SC Abraham","year":"2002","unstructured":"Abraham SC et al (2002) Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol 160(4):1361\u20131369. https:\/\/doi.org\/10.1016\/s0002-9440(10)62563-1","journal-title":"Am J Pathol"},{"issue":"Suppl 1","key":"5_CR2","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1038\/modpathol.3800706","volume":"20","author":"V Adsay","year":"2007","unstructured":"Adsay V (2007) Cystic lesions of the pancreas. Mod Pathol 20(Suppl 1):S71\u2013S93. https:\/\/doi.org\/10.1038\/modpathol.3800706","journal-title":"Mod Pathol"},{"issue":"1","key":"5_CR3","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/SLA.0000000000001173","volume":"263","author":"V Adsay","year":"2016","unstructured":"Adsay V et al (2016) Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: recommendations of verona consensus meeting. Ann Surg 263(1):162\u2013177. https:\/\/doi.org\/10.1097\/SLA.0000000000001173","journal-title":"Ann Surg"},{"key":"5_CR4","unstructured":"American Cancer Society (ACS) (2022) Pancreatic Cancer. American Cancer Society. http:\/\/www.cancer.org\/cancer\/pancreaticcancer\/detailedguide\/pancreatic-cancer-key-statistics. Accessed 30 March 30 2022"},{"issue":"10","key":"5_CR5","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1097\/01.MP.0000087422.24733.62","volume":"16","author":"A Andea","year":"2003","unstructured":"Andea A et al (2003) Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 16(10):996\u20131006. https:\/\/doi.org\/10.1097\/01.MP.0000087422.24733.62","journal-title":"Mod Pathol"},{"issue":"2","key":"5_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/ajcp\/aqw096","volume":"146","author":"G Askan","year":"2016","unstructured":"Askan G et al (2016) Expression of markers of hepatocellular differentiation in pancreatic acinar cell neoplasms: a potential diagnostic pitfall. Am J Clin Pathol 146(2):163\u2013169. https:\/\/doi.org\/10.1093\/ajcp\/aqw096","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"5_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.5858\/133.3.423","volume":"133","author":"O Basturk","year":"2009","unstructured":"Basturk O et al (2009) Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med 133(3):423\u2013438. https:\/\/doi.org\/10.5858\/133.3.423","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"5_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/PAS.0000000000000169","volume":"38","author":"O Basturk","year":"2014","unstructured":"Basturk O et al (2014) Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am J Surg Pathol 38(4):437\u2013447. https:\/\/doi.org\/10.1097\/PAS.0000000000000169","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"5_CR9","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1097\/PAS.0000000000000533","volume":"39","author":"O Basturk","year":"2015","unstructured":"Basturk O et al (2015) A revised classification system and recommendations from the baltimore consensus meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol 39(12):1730\u20131741. https:\/\/doi.org\/10.1097\/PAS.0000000000000533","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"5_CR10","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1097\/PAS.0000000000000408","volume":"39","author":"O Basturk","year":"2015","unstructured":"Basturk O et al (2015) The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol 39(5):683\u2013690. https:\/\/doi.org\/10.1097\/PAS.0000000000000408","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"5_CR11","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/modpathol.2016.98","volume":"29","author":"O Basturk","year":"2016","unstructured":"Basturk O et al (2016) The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. Mod Pathol 29(9):1058\u20131069. https:\/\/doi.org\/10.1038\/modpathol.2016.98","journal-title":"Mod Pathol"},{"key":"5_CR12","unstructured":"Basturk O et al (2019) Pancreatic intraepithelial neoplasia. In: WHO Classification of Tumours Editorial Board (eds) WHO Classification of Tumours: Digestive System Tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 307\u2013309"},{"key":"5_CR13","unstructured":"Basturk O et al (2019) Pancreatic intraductal oncocytic papillary neoplasm. In: WHO Classification of Tumours Editorial Board (eds) WHO Classification of Tumours: Digestive System Tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 315\u2013316"},{"key":"5_CR14","unstructured":"Basturk O et al (2019) Pancreatic mucinous cystic neoplasm. In: WHO Classification of Tumours Editorial Board (eds) WHO Classification of Tumours: Digestive System Tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 319\u2013321"},{"key":"5_CR15","unstructured":"Basturk O et al (2019) Pancreatic intraductal papillary mucinous neoplasm. In: WHO Classification of Tumours Editorial Board (eds) WHO Classification of Tumours: Digestive System Tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 310\u2013314"},{"issue":"1","key":"5_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000442207","volume":"104","author":"R Boyar Cetinkaya","year":"2017","unstructured":"Boyar Cetinkaya R et al (2017) Trends in incidence of neuroendocrine neoplasms in Norway: a report of 16,075 cases from 1993 through 2010. Neuroendocrinology 104(1):1\u201310. https:\/\/doi.org\/10.1159\/000442207","journal-title":"Neuroendocrinology"},{"issue":"4","key":"5_CR17","first-page":"375","volume":"6","author":"WR Brugge","year":"2015","unstructured":"Brugge WR (2015) Diagnosis and management of cystic lesions of the pancreas. J Gastrointest Oncol 6(4):375\u2013388","journal-title":"J Gastrointest Oncol"},{"issue":"5","key":"5_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41416-019-0510-x","volume":"121","author":"E Campello","year":"2019","unstructured":"Campello E et al (2019) The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues. Br J Cancer 121(5):359\u2013371. https:\/\/doi.org\/10.1038\/s41416-019-0510-x","journal-title":"Br J Cancer"},{"issue":"9","key":"5_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4251\/wjgo.v6.i9.311","volume":"6","author":"VM Castellano-Meg\u00edas","year":"2014","unstructured":"Castellano-Meg\u00edas VM et al (2014) Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas. World J Gastrointest Oncol. 6(9):311\u2013324. https:\/\/doi.org\/10.4251\/wjgo.v6.i9.311","journal-title":"World J Gastrointest Oncol."},{"issue":"51","key":"5_CR20","doi-asserted-by":"publisher","first-page":"e5535","DOI":"10.1097\/md.0000000000005535","volume":"95","author":"YR Chang","year":"2016","unstructured":"Chang YR et al (2016) Incidental pancreatic cystic neoplasms in an asymptomatic healthy population of 21,745 individuals: large-scale, single-center cohort study. Medicine (Baltimore) 95(51):e5535. https:\/\/doi.org\/10.1097\/md.0000000000005535","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"5_CR21","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1158\/2159-8290.CD-14-0617","volume":"4","author":"J Chmielecki","year":"2014","unstructured":"Chmielecki J et al (2014) Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discov 4(12):1398\u20131405. https:\/\/doi.org\/10.1158\/2159-8290.CD-14-0617","journal-title":"Cancer Discov"},{"issue":"7","key":"5_CR22","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.gassur.2005.04.008","volume":"9","author":"JD Christein","year":"2005","unstructured":"Christein JD et al (2005) Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas. J Gastrointest Surg 9(7):922\u2013927. https:\/\/doi.org\/10.1016\/j.gassur.2005.04.008","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"5_CR23","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/SLA.0b013e31811f4449","volume":"247","author":"S Crippa","year":"2008","unstructured":"Crippa S et al (2008) Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg 247(4):571\u2013579. https:\/\/doi.org\/10.1097\/SLA.0b013e31811f4449","journal-title":"Ann Surg"},{"issue":"5","key":"5_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1159\/000079823","volume":"4","author":"AR Dhebri","year":"2004","unstructured":"Dhebri AR et al (2004) Diagnosis, treatment and outcome of pancreatoblastoma. Pancreatology 4(5):441\u2013453. https:\/\/doi.org\/10.1159\/000079823","journal-title":"Pancreatology"},{"issue":"12","key":"5_CR25","doi-asserted-by":"publisher","first-page":"e0243164","DOI":"10.1371\/journal.pone.0243164","volume":"15","author":"N Duorui","year":"2020","unstructured":"Duorui N et al (2020) The contemporary trend in worsening prognosis of pancreatic acinar cell carcinoma: a population-based study. PloS One 15(12):e0243164. https:\/\/doi.org\/10.1371\/journal.pone.0243164","journal-title":"PloS One"},{"issue":"6","key":"5_CR26","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.pan.2015.08.007","volume":"15","author":"I Esposito","year":"2015","unstructured":"Esposito I et al (2015) Pathology, genetics and precursors of human and experimental pancreatic neoplasms: an update. Pancreatology 15(6):598\u2013610. https:\/\/doi.org\/10.1016\/j.pan.2015.08.007","journal-title":"Pancreatology"},{"issue":"3","key":"5_CR27","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s11605-009-1115-0","volume":"14","author":"J Franko","year":"2010","unstructured":"Franko J et al (2010) Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients. J Gastrointest Surg 14(3):541\u2013548. https:\/\/doi.org\/10.1007\/s11605-009-1115-0","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"5_CR28","first-page":"1501","volume":"152","author":"M Goggins","year":"1998","unstructured":"Goggins M et al (1998) Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152(6):1501\u20131507","journal-title":"Am J Pathol"},{"issue":"16","key":"5_CR29","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.3748\/wjg.v20.i16.4597","volume":"20","author":"K Guzi\u0144ska-Ustymowicz","year":"2014","unstructured":"Guzi\u0144ska-Ustymowicz K et al (2014) Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract. World J Gastroenterol 20(16):4597\u20134606. https:\/\/doi.org\/10.3748\/wjg.v20.i16.4597","journal-title":"World J Gastroenterol"},{"key":"5_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/den.14240","author":"K Hanada","year":"2022","unstructured":"Hanada K et al (2022) Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia. Digest Endosc. https:\/\/doi.org\/10.1111\/den.14240","journal-title":"Digest Endosc"},{"issue":"1","key":"5_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/path.4884","volume":"242","author":"W Hosoda","year":"2017","unstructured":"Hosoda W et al (2017) Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. J Pathol 242(1):16\u201323. https:\/\/doi.org\/10.1002\/path.4884","journal-title":"J Pathol"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1093\/ajcp\/88.5.639","volume":"88","author":"RH Hruban","year":"1987","unstructured":"Hruban RH et al (1987) A neoplasm with pancreatic and hepatocellular differentiation presenting with subcutaneous fat necrosis. Am J Clin Pathol 88:639\u2013645","journal-title":"Am J Clin Pathol"},{"volume-title":"Tumors of the Pancreas","year":"2007","key":"5_CR33","unstructured":"Hruban RH et al (eds) (2007) Tumors of the Pancreas. Armed Forces Institute of Pathology, Washington, DC"},{"key":"5_CR34","unstructured":"Hruban RH et al (2019) \u201cPancreatic ductal adenocarcinoma. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of Tumours: Digestive System Tumours, 5th ed. International Agency for Research on Cancer, Lyon, France, pp 322\u2013332"},{"key":"5_CR35","unstructured":"Hruban RH et al (2007) Tumors of the pancreas. American Registry of Pathology, Washington, DC. AFIP atlas of tumor pathology, series 4; fascicle 6"},{"issue":"11","key":"5_CR36","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1097\/00000478-200011000-00011","volume":"24","author":"CA Iacobuzio-Donahue","year":"2000","unstructured":"Iacobuzio-Donahue CA et al (2000) Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am J Surg Pathol 24(11):1544\u20131548. https:\/\/doi.org\/10.1097\/00000478-200011000-00011","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"5_CR37","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/PAS.0000000000000357","volume":"39","author":"KT Jang","year":"2015","unstructured":"Jang KT et al (2015) Clinicopathologic characteristics of 29 invasive carcinomas arising in 178 pancreatic mucinous cystic neoplasms with ovarian-type stroma: implications for management and prognosis. Am J Surg Pathol 39(2):179\u2013187. https:\/\/doi.org\/10.1097\/PAS.0000000000000357","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"5_CR38","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/00000658-199910000-00006","volume":"230","author":"RE Jimenez","year":"1999","unstructured":"Jimenez RE et al (1999) Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 230(4):501\u2013511. https:\/\/doi.org\/10.1097\/00000658-199910000-00006","journal-title":"Ann Surg"},{"issue":"11","key":"5_CR39","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1001\/jamasurg.2019.3337","volume":"154","author":"RP Jones","year":"2019","unstructured":"Jones RP et al (2019) Patterns of recurrence after resection of pancreatic ductal adenocarcinoma: a secondary analysis of the ESPAC-4 randomized adjuvant chemotherapy trial. JAMA Surg 154(11):1038\u20131048. https:\/\/doi.org\/10.1001\/jamasurg.2019.3337","journal-title":"JAMA Surg"},{"key":"5_CR40","doi-asserted-by":"publisher","unstructured":"Kanda M et al (2012) Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology 42(4):730\u2013733e9. https:\/\/doi.org\/10.1053\/j.gastro.2011.12.042","DOI":"10.1053\/j.gastro.2011.12.042"},{"key":"5_CR41","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/B978-141604059-0.50038-2","volume-title":"Surgical pathology of the GI tract, liver, biliary tract and pancreas","author":"D Klimstra","year":"2009","unstructured":"Klimstra D, Adsay NV (2009) Adsay NV (2009) Tumors of the pancreas and ampulla of vater. In: Odze R, Goldblum J (eds) Surgical pathology of the GI tract, liver, biliary tract and pancreas. Saunders, Philadelphia, PA, pp 909\u2013960"},{"key":"5_CR42","unstructured":"Kloppel G et al (2019) Solid pseudopapillary neoplasm of the pancreas. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of tumours: digestive system tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 340\u2013342"},{"key":"5_CR43","unstructured":"Kl\u00f6ppel G et al (2019) Pancreatic neuroendocrine neoplasms: introduction. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of tumours: digestive system tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 343\u2013346"},{"key":"5_CR44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.humpath.2018.03.018","volume":"77","author":"B Konukiewitz","year":"2018","unstructured":"Konukiewitz B et al (2018) Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3. Hum Pathol 77:70\u201379. https:\/\/doi.org\/10.1016\/j.humpath.2018.03.018","journal-title":"Hum Pathol"},{"issue":"2","key":"5_CR45","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/MPA.0000000000000253","volume":"44","author":"Y Kuboki","year":"2015","unstructured":"Kuboki Y et al (2015) Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas. Pancreas 44(2):227\u2013235. https:\/\/doi.org\/10.1097\/MPA.0000000000000253","journal-title":"Pancreas"},{"key":"5_CR46","unstructured":"La Rosa S et al (2019) Pancreatic acinar cell carcinoma. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of tumours: digestive system tumours, 5th ed. International Agency for Research on Cancer, Lyon, pp 333\u2013336"},{"key":"5_CR47","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/MPA.0000000000000061","volume":"43","author":"JK Law","year":"2014","unstructured":"Law JK et al (2014) A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas 43:331\u2013337","journal-title":"Pancreas"},{"key":"5_CR48","doi-asserted-by":"crossref","unstructured":"Lester SC (2010) Gastrointestinal specimens (including hepatobiliary and pancreatic specimens. In: Manual of Surgical Pathology, 3rd ed. Elsevier, Philadelphia, PA, pp 323\u2013383","DOI":"10.1016\/B978-0-323-06516-0.10019-0"},{"issue":"12","key":"5_CR49","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1634\/theoncologist.2011-0231","volume":"16","author":"MA Lowery","year":"2011","unstructured":"Lowery MA et al (2011) Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist 16(12):1714\u20131720. https:\/\/doi.org\/10.1634\/theoncologist.2011-0231","journal-title":"Oncologist"},{"issue":"5","key":"5_CR50","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4103\/1947-2714.157477","volume":"7","author":"NO Machado","year":"2015","unstructured":"Machado NO et al (2015) Intraductal Papillary Mucinous Neoplasm of Pancreas. N Am J Med Sci 7(5):160\u2013175. https:\/\/doi.org\/10.4103\/1947-2714.157477","journal-title":"N Am J Med Sci"},{"issue":"5","key":"5_CR51","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/jso.24380","volume":"114","author":"G Marchegiani","year":"2016","unstructured":"Marchegiani G et al (2016) Solid pseudopapillary tumors of the pancreas: specific pathological features predict the likelihood of postoperative recurrence. J Surg Oncol 114(5):597\u2013601. https:\/\/doi.org\/10.1002\/jso.24380","journal-title":"J Surg Oncol"},{"key":"5_CR52","volume-title":"Sternberg\u2019s diagnostic surgical pathology","year":"2015","unstructured":"Mills et al (eds) (2015) Sternberg\u2019s diagnostic surgical pathology, 6th edn. Lippincott Williams & Wilkins, Philadelphia, PA","edition":"6"},{"key":"5_CR53","unstructured":"Morohoshi T Pancreatoblastoma. World Health Organization Classification of Tumours of the Digestive System. IARC Press: Lyon, France, 2010. 319\u2013321."},{"issue":"4","key":"5_CR54","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/00006676-200011000-00001","volume":"21","author":"VR Mujica","year":"2000","unstructured":"Mujica VR et al (2000) Acute pancreatitis secondary to pancreatic carcinoma. Study group patients. Pancreas. 21(4):329\u2013332. https:\/\/doi.org\/10.1097\/00006676-200011000-00001","journal-title":"Pancreas."},{"issue":"9","key":"5_CR55","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1097\/PAS.0000000000000689","volume":"40","author":"T Muraki","year":"2016","unstructured":"Muraki T et al (2016) Undifferentiated carcinoma with osteoclastic giant cells of the pancreas: clinicopathologic analysis of 38 cases highlights a more protracted clinical course than currently appreciated. Am J Surg Pathol 40(9):1203\u20131216. https:\/\/doi.org\/10.1097\/PAS.0000000000000689","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"5_CR56","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.pan.2016.09.011","volume":"16","author":"LN Nilsson","year":"2016","unstructured":"Nilsson LN et al (2016) Nature and management of pancreatic mucinous cystic neoplasm (MCN): a systematic review of the literature. Pancreatology 16(6):1028\u20131036. https:\/\/doi.org\/10.1016\/j.pan.2016.09.011","journal-title":"Pancreatology"},{"key":"5_CR57","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10689-014-9755-y","volume":"14","author":"AL Norris","year":"2015","unstructured":"Norris AL et al (2015) Familial and sporadic pancreatic pancreatic cancer share the same molecular pathogenesis. Fam Cancer 14:95\u2013103","journal-title":"Fam Cancer"},{"issue":"2","key":"5_CR58","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.path.2011.03.001","volume":"4","author":"N Ohike","year":"2011","unstructured":"Ohike N, Morohoshi T (2011) Exocrine pancreatic neoplasms of nonductal origin: acinar cell carcinoma, pancreatoblastoma, and solid-pseudopapillary neoplasm. Surg Pathol Clin. 4(2):579\u2013588. https:\/\/doi.org\/10.1016\/j.path.2011.03.001","journal-title":"Surg Pathol Clin."},{"key":"5_CR59","unstructured":"Ohike N, La Rosa S (2019) Pancreatoblastoma. In: WHO Classification of Tumours Editorial Board (ed) WHO Classification of tumours: digestive system tumour, 5th ed. International Agency for Research on Cancer, Lyon, pp 337\u2013339"},{"issue":"44","key":"5_CR60","doi-asserted-by":"publisher","first-page":"6765","DOI":"10.3748\/wjg.14.6765","volume":"14","author":"T Okabayashi","year":"2008","unstructured":"Okabayashi T, Hanazaki K (2008) Surgical outcome of adenosquamous carcinoma of the pancreas. World J Gastroenterol 14(44):6765\u20136770. https:\/\/doi.org\/10.3748\/wjg.14.6765","journal-title":"World J Gastroenterol"},{"issue":"4","key":"5_CR61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3978\/j.issn.2227-684X.2015.04.05","volume":"4","author":"AO Omiyale","year":"2015","unstructured":"Omiyale AO (2015) Clinicopathological review of pancreatoblastoma in adults. Gland Surg 4(4):322\u2013328. https:\/\/doi.org\/10.3978\/j.issn.2227-684X.2015.04.05","journal-title":"Gland Surg"},{"issue":"8","key":"5_CR62","doi-asserted-by":"publisher","first-page":"896","DOI":"10.4254\/wjh.v13.i8.896","volume":"13","author":"AO Omiyale","year":"2021","unstructured":"Omiyale AO (2021) Solid pseudopapillary neoplasm of the pancreas. World J Hepatol 13(8):896\u2013903. https:\/\/doi.org\/10.4254\/wjh.v13.i8.896","journal-title":"World J Hepatol"},{"issue":"26","key":"5_CR63","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.3748\/wjg.v27.i26.4172","volume":"27","author":"AO Omiyale","year":"2021","unstructured":"Omiyale AO (2021) Adult pancreatoblastoma: current concepts in pathology. World J Gastroenterol 27(26):4172\u20134181. https:\/\/doi.org\/10.3748\/wjg.v27.i26.4172","journal-title":"World J Gastroenterol"},{"issue":"1","key":"5_CR64","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13014-019-1345-6","volume":"4","author":"M Orth","year":"2019","unstructured":"Orth M et al (2019) Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches. Radiat Oncol (London, England) 4(1):141. https:\/\/doi.org\/10.1186\/s13014-019-1345-6","journal-title":"Radiat Oncol (London, England)"},{"issue":"4","key":"5_CR65","first-page":"447","volume":"22","author":"L Oterdoom","year":"2013","unstructured":"Oterdoom L et al (2013) Double-duct sign: do not forget the gallstones. J Gastrointest Liver Dis JGLD 22(4):447\u2013450","journal-title":"J Gastrointest Liver Dis JGLD"},{"issue":"1","key":"5_CR66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14740\/wjon1166","volume":"10","author":"P Rawla","year":"2019","unstructured":"Rawla P et al (2019) Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J Oncol 10(1):10\u201327. https:\/\/doi.org\/10.14740\/wjon1166","journal-title":"World J Oncol"},{"issue":"12","key":"5_CR67","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","volume":"31","author":"G Rindi","year":"2018","unstructured":"Rindi G et al (2018) A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Modern Pathol 31(12):1770\u20131786. https:\/\/doi.org\/10.1038\/s41379-018-0110-y","journal-title":"Modern Pathol"},{"key":"5_CR68","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fmed.2015.00041","volume":"2","author":"S La Rosa","year":"2015","unstructured":"La Rosa S et al (2015) Acinar cell carcinoma of the pancreas: overview of clinicopathologic features and insights into the molecular pathology. Front Med (Lausanne). 2:41. https:\/\/doi.org\/10.3389\/fmed.2015.00041","journal-title":"Front Med (Lausanne)."},{"key":"5_CR69","unstructured":"Rosai J (2011) Pancreas and ampullary region. Rosai and Ackerman\u2019s surgical pathology, 10th ed. Mosby, Edinburgh, pp 1006\u20131055"},{"issue":"10","key":"5_CR70","doi-asserted-by":"publisher","first-page":"342","DOI":"10.4240\/wjgs.v2.i10.342","volume":"2","author":"R Salvia","year":"2010","unstructured":"Salvia R et al (2010) Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas. World J Gastrointest Surg. 2(10):342\u2013346. https:\/\/doi.org\/10.4240\/wjgs.v2.i10.342","journal-title":"World J Gastrointest Surg."},{"issue":"2","key":"5_CR71","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.canlet.2006.09.007","volume":"249","author":"F Sch\u00f6nleben","year":"2007","unstructured":"Sch\u00f6nleben F et al (2007) BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm\/carcinoma (IPMN\/IPMC) of the pancreas. Cancer Lett 249(2):242\u2013248. https:\/\/doi.org\/10.1016\/j.canlet.2006.09.007","journal-title":"Cancer Lett"},{"issue":"1","key":"5_CR72","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/00000478-200201000-00006","volume":"26","author":"G Seidel","year":"2002","unstructured":"Seidel G et al (2002) Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases. Am J Surg Pathol 26(1):56\u201363. https:\/\/doi.org\/10.1097\/00000478-200201000-00006","journal-title":"Am J Surg Pathol"},{"key":"5_CR73","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3948","author":"S Seton-Rogers","year":"2015","unstructured":"Seton-Rogers S (2015) Pancreatic cancer: a matter of timing. Nat Rev Cancer. https:\/\/doi.org\/10.1038\/nrc3948","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"5_CR74","doi-asserted-by":"publisher","first-page":"E252","DOI":"10.1073\/pnas.1114817109","volume":"109","author":"AH Shain","year":"2012","unstructured":"Shain AH et al (2012) Convergent structural alterations define SWItch\/Sucrose NonFermentable (SWI\/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci USA 109(5):E252\u2013E259. https:\/\/doi.org\/10.1073\/pnas.1114817109","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"5_CR75","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/PAP.0b013e31817bf57d","volume":"15","author":"C Shi","year":"2008","unstructured":"Shi C et al (2008) Molecular characterization of pancreatic neoplasms. Adv Anat Pathol 15(4):185\u2013195. https:\/\/doi.org\/10.1097\/PAP.0b013e31817bf57d","journal-title":"Adv Anat Pathol"},{"issue":"2","key":"5_CR76","first-page":"144","volume":"17","author":"A De Souza","year":"2016","unstructured":"De Souza A et al (2016) Diabetes type 2 and pancreatic cancer: a history unfolding. JOP J Pancreas 17(2):144\u2013148","journal-title":"JOP J Pancreas"},{"key":"5_CR77","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program. SEER Stat fact sheets: pancreas cancer. http:\/\/seer.cancer.gov\/statfacts\/html\/pancreas.html. Accessed 01 April 2022"},{"issue":"5","key":"5_CR78","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","volume":"17","author":"M Tanaka","year":"2017","unstructured":"Tanaka M et al (2017) Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology 17(5):738\u2013753. https:\/\/doi.org\/10.1016\/j.pan.2017.07.007","journal-title":"Pancreatology"},{"issue":"4","key":"5_CR79","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1365-2559.1996.tb01419.x","volume":"29","author":"T Terada","year":"1996","unstructured":"Terada T et al (1996) Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. Histopathology 29(4):355\u2013361. https:\/\/doi.org\/10.1111\/j.1365-2559.1996.tb01419.x","journal-title":"Histopathology"},{"issue":"1","key":"5_CR80","first-page":"42","volume":"122","author":"T Terada","year":"1998","unstructured":"Terada T et al (1998) Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med 122(1):42\u201346","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"5_CR81","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4240\/wjgs.v2.i10.337","volume":"2","author":"BG Turner","year":"2010","unstructured":"Turner BG, Brugge WR (2010) Diagnostic and therapeutic endoscopic approaches to intraductal papillary mucinous neoplasm. World J Gastrointest Surg. 2(10):337\u2013341. https:\/\/doi.org\/10.4240\/wjgs.v2.i10.337","journal-title":"World J Gastrointest Surg."},{"issue":"1","key":"5_CR82","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.humpath.2009.07.012","volume":"41","author":"KR Voong","year":"2010","unstructured":"Voong KR et al (2010) Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients. Hum Pathol 41(1):113\u2013122. https:\/\/doi.org\/10.1016\/j.humpath.2009.07.012","journal-title":"Hum Pathol"},{"issue":"6","key":"5_CR83","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1172\/JCI200318882","volume":"112","author":"M Wahrenbrock","year":"2003","unstructured":"Wahrenbrock M et al (2003) Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest 112(6):853\u2013862","journal-title":"J Clin Invest"},{"issue":"5","key":"5_CR84","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/PAS.0000000000001226","volume":"43","author":"T Wang","year":"2019","unstructured":"Wang T et al (2019) Intraductal oncocytic papillary neoplasms: clinical-pathologic characterization of 24 cases, with an emphasis on associated invasive carcinomas. Am J Surg Pathol 43(5):656\u2013661. https:\/\/doi.org\/10.1097\/PAS.0000000000001226","journal-title":"Am J Surg Pathol"},{"key":"5_CR85","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.057","author":"DC Whitecomb","year":"2015","unstructured":"Whitecomb DC et al (2015) Genetics and genetic testing in pancreatic cancer. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2015.07.057","journal-title":"Gastroenterology"},{"issue":"5","key":"5_CR86","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0002-9440(10)65035-3","volume":"156","author":"RE Wilentz","year":"2000","unstructured":"Wilentz RE et al (2000) Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol 156(5):1641\u20131651. https:\/\/doi.org\/10.1016\/S0002-9440(10)65035-3","journal-title":"Am J Pathol"},{"issue":"4","key":"5_CR87","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/MPA.0b013e318215010c","volume":"40","author":"K Yamaguchi","year":"2011","unstructured":"Yamaguchi K et al (2011) Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas 40(4):571\u2013580. https:\/\/doi.org\/10.1097\/MPA.0b013e318215010c","journal-title":"Pancreas"},{"key":"5_CR88","unstructured":"Zamboni G et al (2010) Mucinous cystic neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, pp 300\u2013303"}],"container-title":["Cancer Treatment and Research","Gastrointestinal Malignancies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-61238-1_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:04:17Z","timestamp":1724997857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-61238-1_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031612374","9783031612381"],"references-count":88,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-61238-1_5","relation":{},"ISSN":["0927-3042","2509-8497"],"issn-type":[{"type":"print","value":"0927-3042"},{"type":"electronic","value":"2509-8497"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"31 August 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}