{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T19:58:19Z","timestamp":1743105499224,"version":"3.40.3"},"publisher-location":"Cham","reference-count":33,"publisher":"Springer Nature Switzerland","isbn-type":[{"type":"print","value":"9783031646355"},{"type":"electronic","value":"9783031646362"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-3-031-64636-2_27","type":"book-chapter","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:02:27Z","timestamp":1724738547000},"page":"356-365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interpreting Respiratory Syncytial Virus (RSV) Nucleoprotein Mutations: A Structural and Functional Perspective"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-1866","authenticated-orcid":false,"given":"Mubashir","family":"Hassan","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2467-9890","authenticated-orcid":false,"given":"Saba","family":"Shahzadi","sequence":"additional","affiliation":[]},{"given":"Muhammad","family":"Yasir","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-5095","authenticated-orcid":false,"given":"Andrzej","family":"Kloczkowski","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"27_CR1","first-page":"1606","volume-title":"Nelson Textbook of Pediatrics","author":"J Crowe","year":"2016","unstructured":"Crowe, J.: Respiratory syncytial virus. In: Kliegman, R.M. (ed.) Nelson Textbook of Pediatrics, 20th edn., pp. 1606\u20131609. Elsevier, Philadelphia (2016)","edition":"20"},{"issue":"5","key":"27_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00501-8","volume":"19","author":"AJ Te Velthuis","year":"2021","unstructured":"Te Velthuis, A.J., Grimes, J.M., Fodor, E.: Structural insights into RNA polymerases of negative-sense RNA viruses. Nat. Rev. Microbiol. 19(5), 303318 (2021)","journal-title":"Nat. Rev. Microbiol."},{"key":"27_CR3","doi-asserted-by":"crossref","unstructured":"Nam, H.H., Ison, M.G.: Respiratory syncytial virus infection in adults. BMJ 366 (2019)","DOI":"10.1136\/bmj.l5021"},{"key":"27_CR4","doi-asserted-by":"crossref","unstructured":"Robinson, C.C.: Respiratory Viruses, Clinical Virology Manual, 201\u2013248 (2009)","DOI":"10.1128\/9781555815974.ch17"},{"key":"27_CR5","doi-asserted-by":"crossref","unstructured":"Prabhu, F.R., et al.: Pulmonary infections, in Family Medicine: Principles and Practice. 2022, Springer. p. 1183\u20131202","DOI":"10.1007\/978-3-030-54441-6_91"},{"key":"27_CR6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12016-013-8368-9","volume":"45","author":"AT Borchers","year":"2013","unstructured":"Borchers, A.T., et al.: Respiratory syncytial virus\u2014a comprehensive review. Clin. Rev. Allergy Immunol. 45, 331\u2013379 (2013)","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"10","key":"27_CR7","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1136\/thoraxjnl-2018-212212","volume":"74","author":"JA Coultas","year":"2019","unstructured":"Coultas, J.A., Smyth, R., Openshaw, P.J.: Respiratory syncytial virus (RSV): a scourge from infancy to old age. Thorax 74(10), 986\u2013993 (2019)","journal-title":"Thorax"},{"issue":"2","key":"27_CR8","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1128\/AAC.04119-14","volume":"59","author":"S Challa","year":"2015","unstructured":"Challa, S., et al.: Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob. Agents Chemother. 59(2), 1080\u20131087 (2015)","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5957","key":"27_CR9","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1126\/science.1177634","volume":"326","author":"RG Tawar","year":"2009","unstructured":"Tawar, R.G., et al.: Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science 326(5957), 1279\u20131283 (2009)","journal-title":"Science"},{"issue":"8","key":"27_CR10","doi-asserted-by":"publisher","first-page":"17341738","DOI":"10.1099\/vir.0.053025-0","volume":"94","author":"SE Bakker","year":"2013","unstructured":"Bakker, S.E., et al.: The respiratory syncytial virus nucleoprotein\u2013RNA complex forms a left-handed helical nucleocapsid. J. Gen. Virol. 94(8), 17341738 (2013)","journal-title":"J. Gen. Virol."},{"issue":"1","key":"27_CR11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/pro.3774","volume":"29","author":"AP Pandurangan","year":"2020","unstructured":"Pandurangan, A.P., Blundell, T.L.: Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning. Protein Sci. 29(1), 247\u2013257 (2020)","journal-title":"Protein Sci."},{"issue":"2","key":"27_CR12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/v14020419","volume":"14","author":"T Van Royen","year":"2022","unstructured":"Van Royen, T., et al.: How RSV proteins join forces to overcome the host innate immune response. Viruses 14(2), 419 (2022)","journal-title":"Viruses"},{"issue":"10","key":"27_CR13","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1074\/jbc.RA118.006453","volume":"294","author":"C Esneau","year":"2019","unstructured":"Esneau, C., et al.: Biochemical characterization of the respiratory syncytial virus N0-P complex in solution. J. Biol. Chem. 294(10), 3647\u20133660 (2019)","journal-title":"J. Biol. Chem."},{"issue":"12","key":"27_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010191","volume":"17","author":"JW Chen","year":"2021","unstructured":"Chen, J.W., et al.: Reversion mutations in phosphoprotein P of a codon-pairdeoptimized human respiratory syncytial virus confer increased transcription, immunogenicity, and genetic stability without loss of attenuation. PLoS Pathog. 17(12), e1010191 (2021)","journal-title":"PLoS Pathog."},{"issue":"9","key":"27_CR15","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/pro.5560020916","volume":"2","author":"C Colovos","year":"1993","unstructured":"Colovos, C., Yeates, T.O.: Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci. 2(9), 1511\u20131519 (1993)","journal-title":"Protein Sci."},{"key":"27_CR16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0065-3233(08)60402-7","volume":"23","author":"GT Ramachandran","year":"1968","unstructured":"Ramachandran, G.T., Sasisekharan, V.: Conformation of polypeptides and proteins. Adv. Protein Chem. 23, 283\u2013437 (1968)","journal-title":"Adv. Protein Chem."},{"issue":"1","key":"27_CR17","first-page":"7","volume":"76","author":"I Adzhubei","year":"2013","unstructured":"Adzhubei, I., Jordan, D.M., Sunyaev, S.R.: Predicting functional effect of human missense mutations using PolyPhen-2. Curr. Protoc. Hum. Genet. 76(1), 7\u201320 (2013)","journal-title":"Curr. Protoc. Hum. Genet."},{"issue":"1","key":"27_CR18","doi-asserted-by":"publisher","first-page":"5918","DOI":"10.1038\/s41467-020-19669-x","volume":"11","author":"V Pejaver","year":"2020","unstructured":"Pejaver, V., et al.: Inferring the molecular and phenotypic impact of amino acid variants with MutPred2. Nat. Commun. 11(1), 5918 (2020)","journal-title":"Nat. Commun."},{"issue":"W1","key":"27_CR19","doi-asserted-by":"publisher","first-page":"W350","DOI":"10.1093\/nar\/gky300","volume":"46","author":"CH Rodrigues","year":"2018","unstructured":"Rodrigues, C.H., Pires, D.E., Ascher, D.B.: DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. Nucleic Acids Res. 46(W1), W350\u2013W355 (2018)","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"27_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/pro.3942","volume":"30","author":"CH Rodrigues","year":"2021","unstructured":"Rodrigues, C.H., Pires, D.B., Ascher, D.E.: DynaMut2: assessing changes in stability and flexibility upon single and multiple point missense mutations. Protein Sci. 30(1), 60\u201369 (2021)","journal-title":"Protein Sci."},{"issue":"W1","key":"27_CR21","doi-asserted-by":"publisher","first-page":"W314","DOI":"10.1093\/nar\/gku411","volume":"42","author":"DE Pires","year":"2014","unstructured":"Pires, D.E., Ascher, D.B., Blundell, T.L.: DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Res. 42(W1), W314\u2013W319 (2014)","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"27_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/bioinformatics\/btt691","volume":"30","author":"DE Pires","year":"2014","unstructured":"Pires, D.E., Ascher, D.B., Blundell, T.L.: MCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics 30(3), 335\u2013342 (2014)","journal-title":"Bioinformatics"},{"key":"27_CR23","doi-asserted-by":"crossref","unstructured":"Worth, C.L., Preissner, R., Blundell, T.L.: SDM\u2014a server for predicting effects of mutations on protein stability and malfunction. Nucleic Acids Res. 39(suppl_2), W215\u2013W222 (2011)","DOI":"10.1093\/nar\/gkr363"},{"key":"27_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-015-0548-6","volume":"16","author":"J Laimer","year":"2015","unstructured":"Laimer, J., et al.: MAESTRO-multi agent stability prediction upon point mutations. BMC Bioinf. 16, 1\u201313 (2015)","journal-title":"BMC Bioinf."},{"issue":"1","key":"27_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","volume":"30","author":"EF Pettersen","year":"2021","unstructured":"Pettersen, E.F., et al.: UCSF ChimeraX: structure visualization for researchers, educators, and developers. Protein Sci. 30(1), 70\u201382 (2021)","journal-title":"Protein Sci."},{"key":"27_CR26","doi-asserted-by":"crossref","unstructured":"Gasteiger, E., et al.: Protein identification and analysis tools on the ExPASy server. Springer (2005)","DOI":"10.1385\/1-59259-890-0:571"},{"issue":"8","key":"27_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070166","volume":"8","author":"KY Chang","year":"2013","unstructured":"Chang, K.Y., Yang, J.R.: Analysis and prediction of highly effective antiviral peptides based on random forests. PLoS ONE 8(8), e70166 (2013)","journal-title":"PLoS ONE"},{"key":"27_CR28","doi-asserted-by":"crossref","unstructured":"Meriem, A., et al.: Pathogenic effects of F8 gene mutations identified in the Algerian population using in silico methods. S. Asian J. Exp. Biol. 10(5) (2020)","DOI":"10.38150\/sajeb.10(5).p344-351"},{"key":"27_CR29","doi-asserted-by":"publisher","first-page":"303","DOI":"10.22159\/ijpps.2016v8i12.14737","volume":"8","author":"VB Murthy","year":"2016","unstructured":"Murthy, V.B., Chowdary, M., Sucharitha, I.: In silico prediction of deleterious and non-deleterious nsSNPs in CFTR gene variants. Int J Pharm Pharm Sci 8, 303\u2013306 (2016)","journal-title":"Int J Pharm Pharm Sci"},{"key":"27_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-023-02623-4","author":"CHM Rodrigues","year":"2024","unstructured":"Rodrigues, C.H.M., Portelli, S., Ascher, D.B.: Exploring the effects of missense mutations on protein thermodynamics through structure-based approaches: findings from the CAGI6 challenges. Hum. Genet. (2024). https:\/\/doi.org\/10.1007\/s00439-023-02623-4","journal-title":"Hum. Genet."},{"issue":"5","key":"27_CR31","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1109\/72.870050","volume":"11","author":"SK Shevade","year":"2000","unstructured":"Shevade, S.K., et al.: Improvements to the SMO algorithm for SVM regression. IEEE Trans. Neural Netw. 11(5), 1188\u20131193 (2000)","journal-title":"IEEE Trans. Neural Netw."},{"issue":"9","key":"27_CR32","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1093\/bioinformatics\/btv769","volume":"32","author":"J Laimer","year":"2016","unstructured":"Laimer, J., et al.: MAESTROweb: a web server for structure-based protein stability prediction. Bioinformatics 32(9), 1414\u20131416 (2016)","journal-title":"Bioinformatics"},{"issue":"8","key":"27_CR33","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1039\/C7MB00211D","volume":"13","author":"M Hassan","year":"2017","unstructured":"Hassan, M., et al.: Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence. Mol. BioSyst. 13(8), 1534\u20131544 (2017)","journal-title":"Mol. BioSyst."}],"container-title":["Lecture Notes in Computer Science","Bioinformatics and Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-64636-2_27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T10:09:20Z","timestamp":1728986960000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-64636-2_27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031646355","9783031646362"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-64636-2_27","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"28 August 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"IWBBIO","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Work-Conference on Bioinformatics and Biomedical Engineering","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Gran Canaria","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2024","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"15 July 2024","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"17 July 2024","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"11","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"iwbbio2024","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/iwbbio.ugr.es\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}