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However, remote work poses various challenges, among which team challenges are prominent and highly relevant to early-stage software startups, since effective team collaboration is one key factor for them to operate and succeed in uncertain environments. Challenges faced by early-stage software startup teams are less explored, especially in remote work settings. This research will propose a design framework to address the challenges faced by early-stage software startup teams in remote work settings. This research uses multi-case study to facilitate a deeper understanding of the phenomenon. 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