{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:13:46Z","timestamp":1789704826276,"version":"4.0.1"},"publisher-location":"Cham","reference-count":40,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031765490","type":"print"},{"value":"9783031765506","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-76550-6_1","type":"book-chapter","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:45:56Z","timestamp":1739220356000},"page":"3-7","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations of the Adaptive Immune System and Age-Related Macular Degeneration"],"prefix":"10.1007","author":[{"given":"Lucas","family":"St\u00fcrzbecher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s12974-022-02620-w","volume":"19","author":"AS Alfaar","year":"2022","unstructured":"Alfaar AS, St\u00fcrzbecher L, Diedrichs-M\u00f6hring M, et al. FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration. J Neuroinflammation. 2022;19:260.","journal-title":"J Neuroinflammation"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nri3459","volume":"13","author":"J Ambati","year":"2013","unstructured":"Ambati J, Atkinson JP, Gelfand BD. Immunology of age-related macular degeneration. Nat Rev Immunol. 2013;13:438\u201351.","journal-title":"Nat Rev Immunol"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00018-019-03419-4","volume":"77","author":"V Behnke","year":"2020","unstructured":"Behnke V, Wolf A, Langmann T. The role of lymphocytes and phagocytes in age-related macular degeneration (AMD). Cellular and molecular life sciences: CMLS. 2020;77:781\u20138.","journal-title":"Cellular and molecular life sciences: CMLS"},{"key":"1_CR4","first-page":"1051","volume":"21","author":"S Camelo","year":"2015","unstructured":"Camelo S, Calippe B, Lavalette S, et al. Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. Mol Vis. 2015;21:1051\u20139.","journal-title":"Mol Vis"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000446587","volume":"236","author":"S Camelo","year":"2016","unstructured":"Camelo S, Lavelette S, Guillonneau X, et al. Association of choroidal interleukin-17-producing T lymphocytes and macrophages with geographic atrophy. Ophthalmol J Int d\u2018ophtalmologie Int J Ophthalmol Zeitschrift fur Augenheilkunde. 2016;236:53\u20138.","journal-title":"Ophthalmol J Int d\u2018ophtalmologie Int J Ophthalmol Zeitschrift fur Augenheilkunde"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1159\/000484907","volume":"44","author":"J Chen","year":"2017","unstructured":"Chen J, Wang W, Li Q. Increased Th1\/Th17 responses contribute to low-grade inflammation in age-related macular degeneration. Cell Physiol Biochem. 2017;44:357\u201367.","journal-title":"Cell Physiol Biochem"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","volume":"69","author":"M Chen","year":"2019","unstructured":"Chen M, Luo C, Zhao J, et al. Immune regulation in the aging retina. Prog Retin Eye Res. 2019;69:159\u201372.","journal-title":"Prog Retin Eye Res"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3349\/ymj.2022.63.4.357","volume":"63","author":"YJ Choi","year":"2022","unstructured":"Choi YJ, Lim D, Byeon SH, et al. Chemokine receptor profiles of T cells in patients with age-related macular degeneration. Yonsei Med J. 2022;63:357\u201364.","journal-title":"Yonsei Med J"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1172\/JCI31692","volume":"117","author":"C Combadiere","year":"2007","unstructured":"Combadiere C, Feumi C, Raoul W, et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest. 2007;117:2920\u20138.","journal-title":"J Clin Invest"},{"key":"1_CR10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-23893","volume":"59","author":"DA Copland","year":"2018","unstructured":"Copland DA, Theodoropoulou S, Liu J, et al. A perspective of AMD through the eyes of immunology. Invest Ophthalmol Vis Sci. 2018;59:Amd83-amd92.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"23794","DOI":"10.1038\/srep23794","volume":"6","author":"B Coughlin","year":"2016","unstructured":"Coughlin B, Schnabolk G, Joseph K, et al. Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and gammadeltaT-cells. Sci Rep. 2016;6:23794.","journal-title":"Sci Rep"},{"key":"1_CR12","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.18-25632","volume":"59","author":"CA Curcio","year":"2018","unstructured":"Curcio CA. Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies. Invest Ophthalmol Vis Sci. 2018;59:Amd160-amd181.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1161\/ATVBAHA.122.318079","volume":"43","author":"D Deliyanti","year":"2023","unstructured":"Deliyanti D, Figgett WA, Gebhardt T, et al. CD8(+) T cells promote pathological angiogenesis in ocular neovascular disease. Arterioscler Thromb Vasc Biol. 2023;43:522\u201336.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","volume":"19","author":"A DeMaio","year":"2022","unstructured":"DeMaio A, Mehrotra S, Sambamurti K, et al. The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases. J Neuroinflammation. 2022;19:251.","journal-title":"J Neuroinflammation"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","volume":"22","author":"R Di Micco","year":"2021","unstructured":"Di Micco R, Krizhanovsky V, Baker D, et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 2021;22:75\u201395.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1136\/bjo.2007.129742","volume":"92","author":"MK Ezzat","year":"2008","unstructured":"Ezzat MK, Hann CR, Vuk-Pavlovic S, et al. Immune cells in the human choroid. Br J Ophthalmol. 2008;92:976\u201380.","journal-title":"Br J Ophthalmol"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.ophtha.2013.04.014","volume":"120","author":"C Faber","year":"2013","unstructured":"Faber C, Singh A, Kr\u00fcger Falk M, et al. Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood. Ophthalmology. 2013;120:2310\u20136.","journal-title":"Ophthalmology"},{"key":"1_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112473","volume":"9","author":"MK Falk","year":"2014","unstructured":"Falk MK, Singh A, Faber C, et al. CX3CL1\/CX3CR1 and CCL2\/CCR2 chemokine\/chemokine receptor complex in patients with AMD. PLoS One. 2014a;9:e112473.","journal-title":"PLoS One"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1167\/iovs.14-14107","volume":"55","author":"MK Falk","year":"2014","unstructured":"Falk MK, Singh A, Faber C, et al. Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014b;55:4050\u20136.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR20","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1167\/iovs.06-0636","volume":"47","author":"DS Gregerson","year":"2006","unstructured":"Gregerson DS, Lew KL, McPherson SW, et al. RPE cells resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing. Invest Ophthalmol Vis Sci. 2006;47:5385\u201394.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.1167\/iovs.07-0286","volume":"48","author":"DS Gregerson","year":"2007","unstructured":"Gregerson DS, Heuss ND, Lew KL, et al. Interaction of retinal pigmented epithelial cells and CD4 T cells leads to T-cell anergy. Invest Ophthalmol Vis Sci. 2007;48:4654\u201363.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.exer.2011.01.003","volume":"92","author":"HB Juel","year":"2011","unstructured":"Juel HB, Kaestel C, Folkersen L, et al. Retinal pigment epithelial cells upregulate expression of complement factors after co-culture with activated T cells. Exp Eye Res. 2011;92:180\u20138.","journal-title":"Exp Eye Res"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"8472","DOI":"10.1167\/iovs.12-9963","volume":"53","author":"HB Juel","year":"2012","unstructured":"Juel HB, Faber C, Udsen MS, et al. Chemokine expression in retinal pigment epithelial ARPE-19 cells in response to coculture with activated T cells. Invest Ophthalmol Vis Sci. 2012;53:8472\u201380.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12974-021-02088-0","volume":"18","author":"KS Lee","year":"2021","unstructured":"Lee KS, Lin S, Copland DA, et al. Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration. J Neuroinflammation. 2021;18:32.","journal-title":"J Neuroinflammation"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-9-111","volume":"9","author":"B Liu","year":"2011","unstructured":"Liu B, Wei L, Meyerle C, et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med. 2011;9:1\u201312.","journal-title":"J Transl Med"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.2147\/OPTH.S82116","volume":"9","author":"CF Madelung","year":"2015","unstructured":"Madelung CF, Falk MK, Sorensen TL. The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood. Clin Ophthalmol (Auckland, NZ). 2015;9:1147\u201354.","journal-title":"Clin Ophthalmol (Auckland, NZ)"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","volume":"392","author":"P Mitchell","year":"2018","unstructured":"Mitchell P, Liew G, Gopinath B, et al. Age-related macular degeneration. Lancet. 2018;392:1147\u201359.","journal-title":"Lancet"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/gm315","volume":"4","author":"AM Newman","year":"2012","unstructured":"Newman AM, Gallo NB, Hancox LS, et al. Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Med. 2012;4:16.","journal-title":"Genome Med"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/aos.14072","volume":"97","author":"S Niazi","year":"2019","unstructured":"Niazi S, Krogh Nielsen M, S\u00f8rensen TL, et al. Neutrophil-to-lymphocyte ratio in age-related macular degeneration: a systematic review and meta-analysis. Acta Ophthalmol. 2019;97:558\u201366.","journal-title":"Acta Ophthalmol"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","volume":"8","author":"M Oubaha","year":"2016","unstructured":"Oubaha M, Miloudi K, Dejda A, et al. Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Sci Transl Med. 2016;8:362ra144.","journal-title":"Sci Transl Med"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1442-9071.1984.tb01120.x","volume":"12","author":"P Penfold","year":"1984","unstructured":"Penfold P, Killingsworth M, Sarks S. An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane. Aust J Ophthalmol. 1984;12:23\u201331.","journal-title":"Aust J Ophthalmol"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000119860","volume":"40","author":"W Raoul","year":"2008","unstructured":"Raoul W, Feumi C, Keller N, et al. Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Res. 2008;40:115\u20139.","journal-title":"Ophthalmic Res"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41598-017-00741-4","volume":"7","author":"A Singh","year":"2017","unstructured":"Singh A, Subhi Y, Krogh Nielsen M, et al. Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: a case-control study. Sci Rep. 2017;7:605.","journal-title":"Sci Rep"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"2583601","DOI":"10.1155\/2020\/2583601","volume":"2020","author":"PG Sreekumar","year":"2020","unstructured":"Sreekumar PG, Hinton DR, Kannan R. The emerging role of senescence in ocular disease. Oxidative Med Cell Longev. 2020;2020:2583601.","journal-title":"Oxidative Med Cell Longev"},{"key":"1_CR35","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/aos.13330","volume":"95","author":"Y Subhi","year":"2017","unstructured":"Subhi Y, Lykke Sorensen T. New neovascular age-related macular degeneration is associated with systemic leucocyte activity. Acta Ophthalmol. 2017;95:472\u201380.","journal-title":"Acta Ophthalmol"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.18632\/aging.101329","volume":"9","author":"Y Subhi","year":"2017","unstructured":"Subhi Y, Nielsen MK, Molbech CR, et al. T-cell differentiation and CD56+ levels in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Aging. 2017;9:2436\u201352.","journal-title":"Aging"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"7525","DOI":"10.4049\/jimmunol.181.11.7525","volume":"181","author":"S Sugita","year":"2008","unstructured":"Sugita S, Horie S, Nakamura O, et al. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J Immunol (Baltimore, MD: 1950). 2008;181:7525\u201336.","journal-title":"J Immunol (Baltimore, MD: 1950)"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1167\/iovs.03-0211","volume":"45","author":"P Zamiri","year":"2004","unstructured":"Zamiri P, Zhang Q, Streilein JW. Vulnerability of allogeneic retinal pigment epithelium to immune T-cell-mediated damage in vivo and in vitro. Invest Ophthalmol Vis Sci. 2004;45:177\u201384.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"6580","DOI":"10.1167\/iovs.14-15166","volume":"55","author":"Z Zhao","year":"2014","unstructured":"Zhao Z, Xu P, Jie Z, et al. gammadelta T cells as a major source of IL-17 production during age-dependent RPE degeneration. Invest Ophthalmol Vis Sci. 2014;55:6580\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.4049\/jimmunol.1102415","volume":"188","author":"R Zhou","year":"2012","unstructured":"Zhou R, Horai R, Silver PB, et al. The living eye \u201cdisarms\u201d uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol (Baltimore, MD: 1950). 2012;188:1742\u201350.","journal-title":"J Immunol (Baltimore, MD: 1950)"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases XX"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-76550-6_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:46:10Z","timestamp":1739220370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-76550-6_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031765490","9783031765506"],"references-count":40,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-76550-6_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"11 February 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"IWAAL","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Workshop on Ambient Assisted Living","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Torremolinos","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2011","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"8 June 2011","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 June 2011","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"3","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"7215","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}