{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:49:46Z","timestamp":1775717386890,"version":"3.50.1"},"publisher-location":"Cham","reference-count":29,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031765490","type":"print"},{"value":"9783031765506","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-76550-6_3","type":"book-chapter","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T21:13:39Z","timestamp":1739394819000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RPE Basal Lamina Biology and Pathophysiology Related to Age-Related Macular Degeneration"],"prefix":"10.1007","author":[{"given":"Steffi","family":"Daniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Hulleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"3_CR1","first-page":"171","volume":"10","author":"RA Armstrong","year":"2015","unstructured":"Armstrong RA, Mousavi M. Overview of risk factors for age-related macular degeneration (AMD). J Stem Cells. 2015;10:171\u201391.","journal-title":"J Stem Cells"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1136\/bjo.87.2.212","volume":"87","author":"L Chen","year":"2003","unstructured":"Chen L, Miyamura N, Ninomiya Y, Handa JT. Distribution of the collagen IV isoforms in human Bruch\u2019s membrane. Br J Ophthalmol. 2003;87:212\u20135.","journal-title":"Br J Ophthalmol"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/iovs.62.1.33","volume":"62","author":"L Chen","year":"2021","unstructured":"Chen L, Messinger JD, Kar D, et al. Biometrics, impact, and significance of basal linear deposit and subretinal drusenoid deposit in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2021;62:33.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3_CR4","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.18-25632","volume":"59","author":"CA Curcio","year":"2018","unstructured":"Curcio CA. Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies. Invest Ophthalmol Vis Sci. 2018;59:AMD160-AMD181.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1001\/archopht.117.3.329","volume":"117","author":"CA Curcio","year":"1999","unstructured":"Curcio CA, Millican CL. Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch Ophthalmol. 1999;117:329\u201339.","journal-title":"Arch Ophthalmol"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1007\/s00109-020-01974-z","volume":"98","author":"S Daniel","year":"2020","unstructured":"Daniel S, Renwick M, Chau VQ, et al. Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity. J Mol Med. 2020;98:1639\u201356.","journal-title":"J Mol Med"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1093\/hmg\/ddm198","volume":"16","author":"L Fu","year":"2007","unstructured":"Fu L, Garland D, Yang Z, et al. The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice. Hum Mol Genet. 2007;16:2411\u201322.","journal-title":"Hum Mol Genet"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/690243","volume":"2015","author":"J Gao","year":"2015","unstructured":"Gao J, Liu RT, Cao S, et al. NLRP3 inflammasome: activation and regulation in age-related macular degeneration. Mediat Inflamm. 2015;2015:1\u201311.","journal-title":"Mediat Inflamm"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/hmg\/ddt395","volume":"23","author":"DL Garland","year":"2014","unstructured":"Garland DL, Fernandez-Godino R, Kaur I, et al. Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD\/ML, an inherited macular degeneration. Hum Mol Genet. 2014;23:52\u201368.","journal-title":"Hum Mol Genet"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1093\/hmg\/ddg289","volume":"12","author":"C Hayward","year":"2003","unstructured":"Hayward C, Shu X, Cideciyan AV, et al. Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration. Hum Mol Genet. 2003;12:2657\u201367.","journal-title":"Hum Mol Genet"},{"key":"3_CR11","volume-title":"Retinal degenerative diseases","author":"JD Hulleman","year":"2016","unstructured":"Hulleman JD. Malattia Leventinese\/Doyne honeycomb retinal dystrophy: similarities to age-related macular degeneration and potential therapies. In: Retinal degenerative diseases. Springer; 2016."},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.preteyeres.2016.04.008","volume":"53","author":"KN Khan","year":"2016","unstructured":"Khan KN, Mahroo OA, Khan RS, et al. Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. Prog Retin Eye Res. 2016;53:70\u2013106.","journal-title":"Prog Retin Eye Res"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1047-8477(02)00534-8","volume":"139","author":"C Knupp","year":"2002","unstructured":"Knupp C, Amin SZ, Munro PM, et al. Collagen VI assemblies in age-related macular degeneration. J Struct Biol. 2002;139:181\u20139.","journal-title":"J Struct Biol"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1136\/bjo.82.10.1104","volume":"82","author":"KU Loeffler","year":"1998","unstructured":"Loeffler KU, Lee WR. Terminology of sub-RPE deposits: do we all speak the same language? Br J Ophthalmol. 1998;82:1104\u20135.","journal-title":"Br J Ophthalmol"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"13067","DOI":"10.1073\/pnas.202491599","volume":"99","author":"LY Marmorstein","year":"2002","unstructured":"Marmorstein LY, Munier FL, Arsenijevic Y, et al. Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Proc Natl Acad Sci. 2002;99:13067\u201372.","journal-title":"Proc Natl Acad Sci"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000187632","volume":"190","author":"E Reale","year":"2009","unstructured":"Reale E, Groos S, Eckardt U, et al. New components of \u2018basal laminar deposits\u2019 in age-related macular degeneration. Cells Tissues Organs. 2009;190:170\u201381.","journal-title":"Cells Tissues Organs"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0002-9394(99)00345-1","volume":"129","author":"SR Russell","year":"2000","unstructured":"Russell SR, Mullins RF, Schneider BL, Hageman GS. Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration. Am J Ophthalmol. 2000;129:205\u201314.","journal-title":"Am J Ophthalmol"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1136\/bjo.60.5.324","volume":"60","author":"SH Sarks","year":"1976","unstructured":"Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324\u201341.","journal-title":"Br J Ophthalmol"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1136\/bjo.83.3.358","volume":"83","author":"SH Sarks","year":"1999","unstructured":"Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study. Br J Ophthalmol. 1999;83:358\u201368.","journal-title":"Br J Ophthalmol"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1167\/iovs.06-0443","volume":"48","author":"S Sarks","year":"2007","unstructured":"Sarks S, Cherepanoff S, Killingsworth M, Sarks J. Relationship of basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration. Invest Ophthalmol Vis Sci. 2007;48:968\u201377.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1167\/iovs.16-20955","volume":"58","author":"JB Stanton","year":"2017","unstructured":"Stanton JB, Marmorstein AD, Zhang Y, Marmorstein LY. Deletion of Efemp1 is protective against the development of sub-RPE deposits in mouse eyes. Invest Opthalmol Vis Sci. 2017;58:1455.","journal-title":"Invest Opthalmol Vis Sci"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/9722","volume":"22","author":"EM Stone","year":"1999","unstructured":"Stone EM, Lotery AJ, Munier FL, et al. A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet. 1999;22:199\u2013202.","journal-title":"Nat Genet"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.61.13.19","volume":"61","author":"AA Sura","year":"2020","unstructured":"Sura AA, Chen L, Messinger JD, et al. Measuring the contributions of basal laminar deposit and Bruch\u2019s membrane in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2020;61:19.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.mcna.2021.01.003","volume":"105","author":"CJ Thomas","year":"2021","unstructured":"Thomas CJ, Mirza RG, Gill MK. Age-related macular degeneration. Med Clin North Am. 2021;105:473\u201391.","journal-title":"Med Clin North Am"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.ajo.2012.03.012","volume":"154","author":"JP van de Ven","year":"2012","unstructured":"van de Ven JP, Boon CJ, Smailhodzic D, et al. Short-term changes of basal laminar drusen on spectral-domain optical coherence tomography. Am J Ophthalmol. 2012;154:560\u20137.","journal-title":"Am J Ophthalmol"},{"key":"3_CR26","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/BF02044234","volume":"231","author":"TL van der Schaft","year":"1993","unstructured":"van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PT. Basal laminar deposit in the aging peripheral human retina. Graefes Arch Clin Exp Ophthalmol. 1993;231:470\u20135.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng1294-352","volume":"8","author":"BHF Weber","year":"1994","unstructured":"Weber BHF, Vogt G, Pruett RC, et al. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby\u2019s fundus dystrophy. Nat Genet. 1994;8:352\u20136.","journal-title":"Nat Genet"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","volume":"2","author":"WL Wong","year":"2014","unstructured":"Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106\u201316.","journal-title":"Lancet Glob Health"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1038\/s41598-020-79570-x","volume":"11","author":"DR Woodard","year":"2021","unstructured":"Woodard DR, Nakahara E, Hulleman JD. Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization. Sci Rep. 2021;11:2998.","journal-title":"Sci Rep"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases XX"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-76550-6_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T21:13:43Z","timestamp":1739394823000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-76550-6_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031765490","9783031765506"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-76550-6_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"11 February 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"IWAAL","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Workshop on Ambient Assisted Living","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Torremolinos","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2011","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"8 June 2011","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 June 2011","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"3","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"7215","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}