{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:34:20Z","timestamp":1769844860407,"version":"3.49.0"},"publisher-location":"Cham","reference-count":37,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031765490","type":"print"},{"value":"9783031765506","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-76550-6_75","type":"book-chapter","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:47:11Z","timestamp":1739220431000},"page":"459-463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interplay of Retinal and Choroidal Vasculatures in Ocular Health and Disease"],"prefix":"10.1007","author":[{"given":"Albert L.","family":"Gonzales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Paikai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Maeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"75_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0014-4835(73)90185-1","volume":"15","author":"A Alm","year":"1973","unstructured":"Alm A, Bill A. Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Exp Eye Res. 1973;15:15\u201329.","journal-title":"Exp Eye Res"},{"key":"75_CR2","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.exer.2008.12.012","volume":"88","author":"A Alm","year":"2009","unstructured":"Alm A, Nilsson SF. Uveoscleral outflow\u2014a review. Exp Eye Res. 2009;88:760\u20138.","journal-title":"Exp Eye Res"},{"key":"75_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1136\/bjo.36.9.465","volume":"36","author":"N Ashton","year":"1952","unstructured":"Ashton N. Observations on the choroidal circulation. Br J Ophthalmol. 1952;36:465\u201381.","journal-title":"Br J Ophthalmol"},{"key":"75_CR4","unstructured":"Bird B, Stawicki SP. Anatomy, head and neck, ophthalmic arteries. In: StatPearls. Treasure Island (FL); 2023."},{"key":"75_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","volume":"29","author":"JC Booij","year":"2010","unstructured":"Booij JC, Baas DC, Beisekeeva J, et al. The dynamic nature of Bruch\u2019s membrane. Prog Retin Eye Res. 2010;29:1\u201318.","journal-title":"Prog Retin Eye Res"},{"key":"75_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100994","volume":"87","author":"J Brinks","year":"2022","unstructured":"Brinks J, van Dijk EHC, Klaassen I, et al. Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease. Prog Retin Eye Res. 2022;87:100994.","journal-title":"Prog Retin Eye Res"},{"key":"75_CR7","first-page":"1871","volume":"41","author":"C Delaey","year":"2000","unstructured":"Delaey C, Van de Voorde J. Pressure-induced myogenic responses in isolated bovine retinal arteries. Invest Ophthalmol Vis Sci. 2000;41:1871\u20135.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"75_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1076\/opep.8.4.237.1613","volume":"8","author":"C Delcourt","year":"2001","unstructured":"Delcourt C, Michel F, Colvez A, et al. Associations of cardiovascular disease and its risk factors with age-related macular degeneration: the POLA study. Ophthalmic Epidemiol. 2001;8:237\u201349.","journal-title":"Ophthalmic Epidemiol"},{"key":"75_CR9","first-page":"2140","volume":"39","author":"W Drexler","year":"1998","unstructured":"Drexler W, Findl O, Schmetterer L, et al. Eye elongation during accommodation in humans: differences between emmetropes and myopes. Invest Ophthalmol Vis Sci. 1998;39:2140\u20137.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"75_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/OPX.0000000000001470","volume":"97","author":"RC Druckenbrod","year":"2020","unstructured":"Druckenbrod RC, Asefzadeh B, Bertolet A. Impact of cardiovascular disease risk factors on subfoveal choroidal thickness by enhanced-depth spectral domain optical coherence tomography. Optom Vis Sci. 2020;97:73\u201380.","journal-title":"Optom Vis Sci"},{"key":"75_CR11","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.935135","volume":"28","author":"J Dziedziak","year":"2022","unstructured":"Dziedziak J, Zaleska-Zmijewska A, Szaflik JP, Cudnoch-Jedrzejewska A. Impact of arterial hypertension on the eye: a review of the pathogenesis, diagnostic methods, and treatment of hypertensive retinopathy. Med Sci Monit. 2022;28:e935135.","journal-title":"Med Sci Monit"},{"key":"75_CR12","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1136\/bjophthalmol-2015-307560","volume":"100","author":"A Farioli","year":"2016","unstructured":"Farioli A, Hemmingsson T, Kriebel D. Vascular risk factors and rhegmatogenous retinal detachment: a follow-up of a national cohort of Swedish men. Br J Ophthalmol. 2016;100:907\u201313.","journal-title":"Br J Ophthalmol"},{"key":"75_CR13","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1093\/eurheartj\/eht023","volume":"34","author":"J Flammer","year":"2013","unstructured":"Flammer J, Konieczka K, Bruno RM, et al. The eye and the heart. Eur Heart J. 2013;34:1270\u20138.","journal-title":"Eur Heart J"},{"issue":"Pt 6","key":"75_CR14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/eye.1987.107","volume":"1","author":"WS Foulds","year":"1987","unstructured":"Foulds WS. Is your vitreous really necessary? The role of the vitreous in the eye with particular reference to retinal attachment, detachment and the mode of action of vitreous substitutes. Eye (Lond). 1987;1(Pt 6):641\u201364.","journal-title":"Eye (Lond)"},{"key":"75_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/BF00224463","volume":"15","author":"AW Fryczkowski","year":"1991","unstructured":"Fryczkowski AW, Sherman MD, Walker J. Observations on the lobular organization of the human choriocapillaris. Int Ophthalmol. 1991;15:109\u201320.","journal-title":"Int Ophthalmol"},{"key":"75_CR16","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000268030","volume":"29","author":"RH Funk","year":"1997","unstructured":"Funk RH. Blood supply of the retina. Ophthalmic Res. 1997;29:320\u20135.","journal-title":"Ophthalmic Res"},{"key":"75_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/sj.eye.6700197","volume":"16","author":"NG Ghazi","year":"2002","unstructured":"Ghazi NG, Green WR. Pathology and pathogenesis of retinal detachment. Eye (Lond). 2002;16:411\u201321.","journal-title":"Eye (Lond)"},{"key":"75_CR18","doi-asserted-by":"publisher","first-page":"27022","DOI":"10.1073\/pnas.1922755117","volume":"117","author":"AL Gonzales","year":"2020","unstructured":"Gonzales AL, Klug NR, Moshkforoush A, et al. Contractile pericytes determine the direction of blood flow at capillary junctions. Proc Natl Acad Sci USA. 2020;117:27022\u201333.","journal-title":"Proc Natl Acad Sci USA"},{"key":"75_CR19","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1097\/01.hjh.0000222759.61735.98","volume":"24","author":"AD Hughes","year":"2006","unstructured":"Hughes AD, Martinez-Perez E, Jabbar AS, et al. Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J Hypertens. 2006;24:889\u201394.","journal-title":"J Hypertens"},{"key":"75_CR20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.4103\/1673-5374.350192","volume":"18","author":"G Kaur","year":"2023","unstructured":"Kaur G, Singh NK. Inflammation and retinal degenerative diseases. Neural Regen Res. 2023;18:513\u20138.","journal-title":"Neural Regen Res"},{"key":"75_CR21","first-page":"2399","volume":"33","author":"JW Kiel","year":"1992","unstructured":"Kiel JW, Shepherd AP. Autoregulation of choroidal blood flow in the rabbit. Invest Ophthalmol Vis Sci. 1992;33:2399\u2013410.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"75_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/ar.1091910304","volume":"191","author":"ML Kirby","year":"1978","unstructured":"Kirby ML, Diab IM, Mattio TG. Development of adrenergic innervation of the iris and fluorescent ganglion cells in the choroid of the chick eye. Anat Rec. 1978;191:311\u20139.","journal-title":"Anat Rec"},{"key":"75_CR23","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1126\/science.2396104","volume":"249","author":"M LaBarbera","year":"1990","unstructured":"LaBarbera M. Principles of design of fluid transport systems in zoology. Science. 1990;249:992\u20131000.","journal-title":"Science"},{"key":"75_CR24","first-page":"2678","volume":"41","author":"A Longo","year":"2000","unstructured":"Longo A, Geiser M, Riva CE. Subfoveal choroidal blood flow in response to light-dark exposure. Invest Ophthalmol Vis Sci. 2000;41:2678\u201383.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"75_CR25","doi-asserted-by":"crossref","unstructured":"Marmor MF. Chapter 19 - Mechanisms of normal retinal adhesion. Retina. 2013;1447\u201364.","DOI":"10.1016\/B978-1-4557-0737-9.00019-9"},{"key":"75_CR26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/APO.0000000000000496","volume":"11","author":"MM Mauschitz","year":"2022","unstructured":"Mauschitz MM, Finger RP. Age-related macular degeneration and cardiovascular diseases: revisiting the common soil theory. Asia Pac J Ophthalmol (Phila). 2022;11:94\u20139.","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"Pt 2","key":"75_CR27","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/eye.1991.32","volume":"5","author":"LM Parver","year":"1991","unstructured":"Parver LM. Temperature modulating action of choroidal blood flow. Eye (Lond). 1991;5(Pt 2):181\u20135.","journal-title":"Eye (Lond)"},{"key":"75_CR28","doi-asserted-by":"publisher","first-page":"8979","DOI":"10.3390\/ijms24108979","volume":"24","author":"R Pinelli","year":"2023","unstructured":"Pinelli R, Ferrucci M, Berti C, et al. The essential role of light-induced autophagy in the inner choroid\/outer retinal neurovascular unit in baseline conditions and degeneration. Int J Mol Sci. 2023;24:8979.","journal-title":"Int J Mol Sci"},{"key":"75_CR29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/sj.eye.6700246","volume":"17","author":"K Polak","year":"2003","unstructured":"Polak K, Polska E, Luksch A, et al. Choroidal blood flow and arterial blood pressure. Eye (Lond). 2003;17:84\u20138.","journal-title":"Eye (Lond)"},{"key":"75_CR30","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S1350-9462(01)00012-X","volume":"20","author":"JM Provis","year":"2001","unstructured":"Provis JM. Development of the primate retinal vasculature. Prog Retin Eye Res. 2001;20:799\u2013821.","journal-title":"Prog Retin Eye Res"},{"key":"75_CR31","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.3390\/ijms22031296","volume":"22","author":"Y Ruan","year":"2021","unstructured":"Ruan Y, Jiang S, Gericke A. Age-related macular degeneration: role of oxidative stress and blood vessels. Int J Mol Sci. 2021;22:1296.","journal-title":"Int J Mol Sci"},{"key":"75_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2022.100145","volume":"2","author":"SS Saraf","year":"2022","unstructured":"Saraf SS, Lacy M, Hunt MS, et al. Demographics and seasonality of retinal detachment, retinal breaks, and posterior vitreous detachment from the intelligent research in sight registry. Ophthalmol Sci. 2022;2:100145.","journal-title":"Ophthalmol Sci"},{"key":"75_CR33","doi-asserted-by":"publisher","first-page":"e63040","DOI":"10.7554\/eLife.63040","volume":"10","author":"P Thakore","year":"2021","unstructured":"Thakore P, Alvarado MG, Ali S, et al. Brain endothelial cell TRPA1 channels initiate neurovascular coupling. elife. 2021;10:e63040.","journal-title":"elife"},{"key":"75_CR34","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/S0161-6420(82)34663-1","volume":"89","author":"MO Tso","year":"1982","unstructured":"Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology. 1982;89:1132\u201345.","journal-title":"Ophthalmology"},{"key":"75_CR35","first-page":"878","volume":"19","author":"R Uddman","year":"1980","unstructured":"Uddman R, Alumets J, Ehinger B, et al. Vasoactive intestinal peptide nerves in ocular and orbital structures of the cat. Invest Ophthalmol Vis Sci. 1980;19:878\u201385.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"75_CR36","volume":"14","author":"H Vyawahare","year":"2022","unstructured":"Vyawahare H, Shinde P. Age-related macular degeneration: epidemiology, pathophysiology, diagnosis, and treatment. Cureus. 2022;14:e29583.","journal-title":"Cureus"},{"key":"75_CR37","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2014.02.001","volume":"40","author":"DY Yu","year":"2014","unstructured":"Yu DY, Yu PK, Cringle SJ, et al. Functional and morphological characteristics of the retinal and choroidal vasculature. Prog Retin Eye Res. 2014;40:53\u201393.","journal-title":"Prog Retin Eye Res"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases XX"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-76550-6_75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:47:14Z","timestamp":1739220434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-76550-6_75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031765490","9783031765506"],"references-count":37,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-76550-6_75","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"11 February 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"IWAAL","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Workshop on Ambient Assisted Living","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Torremolinos","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Spain","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2011","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"8 June 2011","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 June 2011","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"3","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"7215","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}