{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:27:19Z","timestamp":1792801639391,"version":"4.5.0"},"publisher-location":"Cham","reference-count":132,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031791451","type":"print"},{"value":"9783031791468","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-79146-8_12","type":"book-chapter","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T01:55:51Z","timestamp":1742522151000},"page":"185-199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Microbiome Dysbiosis and Citrullination in Rheumatoid Arthritis"],"prefix":"10.1007","author":[{"given":"Xia","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulveer","family":"Mankia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Meade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"issue":"11","key":"12_CR1","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","volume":"43","author":"JA Aas","year":"2005","unstructured":"Aas JA et al (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43(11):5721\u20135732","journal-title":"J Clin Microbiol"},{"issue":"9","key":"12_CR2","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569\u20132581","journal-title":"Arthritis Rheum"},{"issue":"8","key":"12_CR3","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1128\/IAI.01924-05","volume":"74","author":"MN Al-Qutub","year":"2006","unstructured":"Al-Qutub MN et al (2006) Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharide. Infect Immun 74(8):4474\u20134485","journal-title":"Infect Immun"},{"issue":"4","key":"12_CR4","doi-asserted-by":"publisher","first-page":"506","DOI":"10.4103\/ijdr.IJDR_662_17","volume":"30","author":"D Anusha","year":"2019","unstructured":"Anusha D et al (2019) Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: a randomized controlled trial. Indian J Dent Res 30(4):506\u2013511","journal-title":"Indian J Dent Res"},{"issue":"6","key":"12_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1136\/annrheumdis-2011-200668","volume":"71","author":"L \u00c4rlestig","year":"2012","unstructured":"\u00c4rlestig L et al (2012) Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden. Ann Rheum Dis 71(6):825\u2013829","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"12_CR6","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1002\/art.37911","volume":"65","author":"L Barra","year":"2013","unstructured":"Barra L et al (2013) Anti\u2013citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients. Arthritis Rheum 65(6):1439\u20131447","journal-title":"Arthritis Rheum"},{"key":"12_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00251-011-0528-6","volume":"63","author":"M Bax","year":"2011","unstructured":"Bax M et al (2011) Genetics of rheumatoid arthritis: what have we learned? Immunogenetics 63:459\u2013466","journal-title":"Immunogenetics"},{"key":"12_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00296-019-04460-z","volume":"40","author":"K Bia\u0142ow\u0105s","year":"2020","unstructured":"Bia\u0142ow\u0105s K et al (2020) Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis. Rheumatol Int 40:455\u2013463","journal-title":"Rheumatol Int"},{"issue":"8","key":"12_CR9","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/ismej.2010.30","volume":"4","author":"EM Bik","year":"2010","unstructured":"Bik EM et al (2010) Bacterial diversity in the oral cavity of 10 healthy individuals. ISME J 4(8):962\u2013974","journal-title":"ISME J"},{"key":"12_CR10","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1007\/s00296-013-2781-5","volume":"33","author":"B B\u0131y\u0131ko\u011flu","year":"2013","unstructured":"B\u0131y\u0131ko\u011flu B et al (2013) Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int 33:2607\u20132616","journal-title":"Rheumatol Int"},{"issue":"684","key":"12_CR11","doi-asserted-by":"publisher","first-page":"eabq8476","DOI":"10.1126\/scitranslmed.abq8476","volume":"15","author":"RC Brewer","year":"2023","unstructured":"Brewer RC et al (2023) Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med 15(684):eabq8476","journal-title":"Sci Transl Med"},{"issue":"6","key":"12_CR12","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","volume":"24","author":"S Byrne","year":"2009","unstructured":"Byrne S et al (2009) Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol 24(6):469\u2013477","journal-title":"Oral Microbiol Immunol"},{"issue":"4","key":"12_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151967","volume":"11","author":"JD Cecil","year":"2016","unstructured":"Cecil JD et al (2016) Differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens. PLoS One 11(4):e0151967","journal-title":"PLoS One"},{"issue":"9","key":"12_CR14","doi-asserted-by":"publisher","first-page":"752","DOI":"10.3390\/membranes13090752","volume":"13","author":"LA Charpentier","year":"2023","unstructured":"Charpentier LA et al (2023) Bacterial outer membrane vesicles and immune modulation of the host. Membranes 13(9):752","journal-title":"Membranes"},{"issue":"1","key":"12_CR15","doi-asserted-by":"publisher","first-page":"17126","DOI":"10.1038\/s41598-018-35473-6","volume":"8","author":"B Chen","year":"2018","unstructured":"Chen B et al (2018) Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening. Sci Rep 8(1):17126","journal-title":"Sci Rep"},{"issue":"2","key":"12_CR16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/annrheumdis-2020-216972","volume":"80","author":"Z Cheng","year":"2021","unstructured":"Cheng Z et al (2021) Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis. Ann Rheum Dis 80(2):162\u2013168","journal-title":"Ann Rheum Dis"},{"issue":"668","key":"12_CR17","doi-asserted-by":"publisher","first-page":"eabn5166","DOI":"10.1126\/scitranslmed.abn5166","volume":"14","author":"ME Chriswell","year":"2022","unstructured":"Chriswell ME et al (2022) Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum. Sci Transl Med 14(668):eabn5166","journal-title":"Sci Transl Med"},{"issue":"11","key":"12_CR18","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1462-5822.2009.01349.x","volume":"11","author":"SR Coats","year":"2009","unstructured":"Coats SR et al (2009) Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1-and 4\u2032-phosphatase activities. Cell Microbiol 11(11):1587\u20131599","journal-title":"Cell Microbiol"},{"key":"12_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1034\/j.1600-051X.29.s2.4.x","volume":"29","author":"CM Cobb","year":"2002","unstructured":"Cobb CM (2002) Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol 29:22\u201332","journal-title":"J Clin Periodontol"},{"issue":"1","key":"12_CR20","doi-asserted-by":"publisher","first-page":"8379","DOI":"10.1038\/s41598-019-44674-6","volume":"9","author":"JD Corr\u00eaa","year":"2019","unstructured":"Corr\u00eaa JD et al (2019) Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep 9(1):8379","journal-title":"Sci Rep"},{"key":"12_CR21","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00784-018-2420-3","volume":"23","author":"R Cosgarea","year":"2019","unstructured":"Cosgarea R et al (2019) Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig 23:141\u2013151","journal-title":"Clin Oral Investig"},{"issue":"9","key":"12_CR22","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1128\/IAI.72.9.5041-5051.2004","volume":"72","author":"RP Darveau","year":"2004","unstructured":"Darveau RP et al (2004) Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 72(9):5041\u20135051","journal-title":"Infect Immun"},{"issue":"9","key":"12_CR23","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.4049\/jimmunol.1301970","volume":"192","author":"SG de Aquino","year":"2014","unstructured":"de Aquino SG et al (2014) Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2-and IL-1\u2013driven Th17 response. J Immunol 192(9):4103\u20134111","journal-title":"J Immunol"},{"key":"12_CR24","doi-asserted-by":"publisher","first-page":"1759720X1985851","DOI":"10.1177\/1759720X19858514","volume":"11","author":"R de Oliveira Ferreira","year":"2019","unstructured":"de Oliveira Ferreira R et al (2019) Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis 11:1759720X19858514","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"3","key":"12_CR25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/jcpe.13756","volume":"50","author":"P De Pablo","year":"2023","unstructured":"De Pablo P et al (2023) Outcomes of periodontal therapy in rheumatoid arthritis: the opera feasibility randomized trial. J Clin Periodontol 50(3):295\u2013306","journal-title":"J Clin Periodontol"},{"issue":"2","key":"12_CR26","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/odi.12834","volume":"25","author":"S Deschamps-Lenhardt","year":"2019","unstructured":"Deschamps-Lenhardt S et al (2019) Association between periodontitis and chronic kidney disease: systematic review and meta-analysis. Oral Dis 25(2):385\u2013402","journal-title":"Oral Dis"},{"issue":"14","key":"12_CR27","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","volume":"117","author":"CA Dinarello","year":"2011","unstructured":"Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117(14):3720\u20133732","journal-title":"Blood"},{"key":"12_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2147\/JIR.S326896","volume":"15","author":"N Ding","year":"2022","unstructured":"Ding N et al (2022) The effects of non-surgical periodontitis therapy on the clinical features and serological parameters of patients suffering from rheumatoid arthritis as well as chronic periodontitis. J Inflamm Res 15:177\u2013185","journal-title":"J Inflamm Res"},{"issue":"8","key":"12_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255446","volume":"16","author":"M Duan","year":"2021","unstructured":"Duan M et al (2021) Characteristics of gut microbiota in people with obesity. PLoS One 16(8):e0255446","journal-title":"PLoS One"},{"issue":"5","key":"12_CR30","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3390\/jcm8050630","volume":"8","author":"K Eriksson","year":"2019","unstructured":"Eriksson K et al (2019) Periodontal health and oral microbiota in patients with rheumatoid arthritis. J Clin Med 8(5):630","journal-title":"J Clin Med"},{"issue":"8","key":"12_CR31","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.3390\/microorganisms9081657","volume":"9","author":"A Esberg","year":"2021","unstructured":"Esberg A et al (2021) Oral microbiota identifies patients in early onset rheumatoid arthritis. Microorganisms 9(8):1657","journal-title":"Microorganisms"},{"issue":"10","key":"12_CR32","first-page":"591","volume":"18","author":"A Finckh","year":"2022","unstructured":"Finckh A et al (2022) Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol 18(10):591\u2013602","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"12_CR33","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1002\/art.22983","volume":"56","author":"C Foulquier","year":"2007","unstructured":"Foulquier C et al (2007) Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum 56(11):3541\u20133553","journal-title":"Arthritis Rheum"},{"key":"12_CR34","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fimmu.2016.00080","volume":"7","author":"NR Fuggle","year":"2016","unstructured":"Fuggle NR et al (2016) Hand to mouth: a systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis. Front Immunol 7:80","journal-title":"Front Immunol"},{"issue":"6230","key":"12_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.aaa4972","volume":"348","author":"WS Garrett","year":"2015","unstructured":"Garrett WS (2015) Cancer and the microbiota. Science 348(6230):80\u201386","journal-title":"Science"},{"issue":"1","key":"12_CR36","doi-asserted-by":"publisher","first-page":"11969","DOI":"10.1038\/srep11969","volume":"5","author":"T Goulas","year":"2015","unstructured":"Goulas T et al (2015) Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. Sci Rep 5(1):11969","journal-title":"Sci Rep"},{"issue":"2","key":"12_CR37","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","volume":"98","author":"DT Graves","year":"2019","unstructured":"Graves DT, Corr\u00eaa JD, Silva TA (2019) The oral microbiota is modified by systemic diseases. J Dent Res 98(2):148\u2013156","journal-title":"J Dent Res"},{"issue":"11","key":"12_CR38","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1128\/JCM.36.11.3239-3242.1998","volume":"36","author":"AL Griffen","year":"1998","unstructured":"Griffen AL et al (1998) Prevalence of Porphyromonas gingivalis and periodontal health status. J Clin Microbiol 36(11):3239\u20133242","journal-title":"J Clin Microbiol"},{"issue":"7","key":"12_CR39","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1902\/jop.2011.100565","volume":"82","author":"A Guentsch","year":"2011","unstructured":"Guentsch A et al (2011) Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. J Periodontol 82(7):1051\u20131060","journal-title":"J Periodontol"},{"issue":"6","key":"12_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100838","volume":"9","author":"N Gully","year":"2014","unstructured":"Gully N et al (2014) Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One 9(6):e100838","journal-title":"PLoS One"},{"key":"12_CR41","doi-asserted-by":"publisher","first-page":"102590","DOI":"10.1016\/j.ebiom.2019.11.051","volume":"51","author":"M Gurung","year":"2020","unstructured":"Gurung M et al (2020) Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine 51:102590","journal-title":"EBioMedicine"},{"issue":"10","key":"12_CR42","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1016\/j.biocel.2006.03.008","volume":"38","author":"B Gy\u00f6rgy","year":"2006","unstructured":"Gy\u00f6rgy B et al (2006) Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol 38(10):1662\u20131677","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"12_CR43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","volume":"10","author":"G Hajishengallis","year":"2011","unstructured":"Hajishengallis G et al (2011) Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe 10(5):497\u2013506","journal-title":"Cell Host Microbe"},{"issue":"2","key":"12_CR44","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/jre.12002","volume":"48","author":"G Harvey","year":"2013","unstructured":"Harvey G et al (2013) Expression of peptidylarginine deiminase-2 and-4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res 48(2):252\u2013261","journal-title":"J Periodontal Res"},{"issue":"5","key":"12_CR45","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.chom.2023.03.018","volume":"31","author":"M Hong","year":"2023","unstructured":"Hong M et al (2023) Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles. Cell Host Microbe 31(5):798\u2013810. e7","journal-title":"Cell Host Microbe"},{"issue":"6","key":"12_CR46","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1155\/2013\/726598","volume":"35","author":"F Ingegnoli","year":"2013","unstructured":"Ingegnoli F, Castelli R, Gualtierotti R (2013) Rheumatoid factors: clinical applications. Dis Markers 35(6):727\u2013734","journal-title":"Dis Markers"},{"key":"12_CR47","doi-asserted-by":"publisher","first-page":"4899824","DOI":"10.1155\/2022\/4899824","volume":"2022","author":"S Jiang","year":"2022","unstructured":"Jiang S et al (2022) Dataset for genome sequencing and De Novo assembly of the candidate phyla radiation in supragingival plaque. Can J Infect Dis Med Microbiol 2022:4899824","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"3","key":"12_CR48","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3390\/toxins3030242","volume":"3","author":"A Johansson","year":"2011","unstructured":"Johansson A (2011) Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. Toxins 3(3):242\u2013259","journal-title":"Toxins"},{"key":"12_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00296-011-2284-1","volume":"33","author":"R Joseph","year":"2013","unstructured":"Joseph R et al (2013) Association between chronic periodontitis and rheumatoid arthritis: a hospital-based case\u2013control study. Rheumatol Int 33:103\u2013109","journal-title":"Rheumatol Int"},{"issue":"4","key":"12_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174782","volume":"12","author":"S Kageyama","year":"2017","unstructured":"Kageyama S et al (2017) Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis. PLoS One 12(4):e0174782","journal-title":"PLoS One"},{"issue":"2","key":"12_CR51","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jobcr.2019.02.002","volume":"9","author":"S Kaushal","year":"2019","unstructured":"Kaushal S et al (2019) Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res 9(2):128\u2013132","journal-title":"J Oral Biol Craniofac Res"},{"issue":"1","key":"12_CR52","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1128\/IAI.73.1.453-458.2005","volume":"73","author":"P Kelk","year":"2005","unstructured":"Kelk P et al (2005) Abundant secretion of bioactive interleukin-1\u03b2 by human macrophages induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 73(1):453\u2013458","journal-title":"Infect Immun"},{"issue":"3","key":"12_CR53","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/art.39491","volume":"68","author":"N Kharlamova","year":"2016","unstructured":"Kharlamova N et al (2016) Antibodies to Porphyromonas gingivalis indicate interaction between oral infection, smoking, and risk genes in rheumatoid arthritis etiology. Arthritis Rheum 68(3):604\u2013613","journal-title":"Arthritis Rheum"},{"issue":"10","key":"12_CR54","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/sj.bdj.2016.865","volume":"221","author":"M Kilian","year":"2016","unstructured":"Kilian M et al (2016) The oral microbiome\u2013an update for oral healthcare professionals. Br Dent J 221(10):657\u2013666","journal-title":"Br Dent J"},{"issue":"1","key":"12_CR55","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1034\/j.1600-0757.2001.22250102.x","volume":"25","author":"DF Kinane","year":"2000","unstructured":"Kinane DF (2000) Causation and pathogenesis of periodontal disease. Periodontology 25(1):8\u201320","journal-title":"Periodontology"},{"issue":"1","key":"12_CR56","first-page":"1","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN (2017) Periodontal diseases. Nat Rev Dis Prim 3(1):1\u201314","journal-title":"Nat Rev Dis Prim"},{"issue":"8","key":"12_CR57","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1002\/art.23618","volume":"58","author":"A Kinloch","year":"2008","unstructured":"Kinloch A et al (2008) Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum 58(8):2287\u20132295","journal-title":"Arthritis Rheum"},{"issue":"369","key":"12_CR58","doi-asserted-by":"publisher","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","volume":"8","author":"MF Konig","year":"2016","unstructured":"Konig MF et al (2016) Aggregatibacter actinomycetemcomitans\u2013induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med 8(369):369ra176","journal-title":"Sci Transl Med"},{"issue":"3","key":"12_CR59","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s11926-014-0408-9","volume":"16","author":"J Koziel","year":"2014","unstructured":"Koziel J, Mydel P, Potempa J (2014) The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep 16(3):408","journal-title":"Curr Rheumatol Rep"},{"issue":"5","key":"12_CR60","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/154405910308200503","volume":"82","author":"P Kumar","year":"2003","unstructured":"Kumar P et al (2003) New bacterial species associated with chronic periodontitis. J Dent Res 82(5):338\u2013344","journal-title":"J Dent Res"},{"issue":"3","key":"12_CR61","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.molmed.2014.11.004","volume":"21","author":"RJ Lamont","year":"2015","unstructured":"Lamont RJ, Hajishengallis G (2015) Polymicrobial synergy and dysbiosis in inflammatory disease. Trends Mol Med 21(3):172\u2013183","journal-title":"Trends Mol Med"},{"issue":"12","key":"12_CR62","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G (2018) The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol 16(12):745\u2013759","journal-title":"Nat Rev Microbiol"},{"key":"12_CR63","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00784-015-1556-7","volume":"20","author":"O Laugisch","year":"2016","unstructured":"Laugisch O et al (2016) Citrullination in the periodontium\u2014a possible link between periodontitis and rheumatoid arthritis. Clin Oral Investig 20:675\u2013683","journal-title":"Clin Oral Investig"},{"issue":"1","key":"12_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-021-01597-x","volume":"21","author":"R Lehenaff","year":"2021","unstructured":"Lehenaff R et al (2021) Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study. BMC Oral Health 21(1):1\u201311","journal-title":"BMC Oral Health"},{"issue":"2","key":"12_CR65","doi-asserted-by":"publisher","first-page":"869","DOI":"10.4049\/jimmunol.1003252","volume":"186","author":"S Liang","year":"2011","unstructured":"Liang S et al (2011) The C5a receptor impairs IL-12\u2013dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol 186(2):869\u2013877","journal-title":"J Immunol"},{"issue":"6","key":"12_CR66","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/ijms20061414","volume":"20","author":"D Liccardo","year":"2019","unstructured":"Liccardo D et al (2019) Periodontal disease: a risk factor for diabetes and cardiovascular disease. Int J Mol Sci 20(6):1414","journal-title":"Int J Mol Sci"},{"issue":"7","key":"12_CR67","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1002\/art.40485","volume":"70","author":"I Lopez-Oliva","year":"2018","unstructured":"Lopez-Oliva I et al (2018) Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis. Arthritis Rheum 70(7):1008\u20131013","journal-title":"Arthritis Rheum"},{"issue":"7","key":"12_CR68","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/jcpe.13117","volume":"46","author":"L Loutan","year":"2019","unstructured":"Loutan L et al (2019) Periodontal status correlates with anti-citrullinated protein antibodies in first-degree relatives of individuals with rheumatoid arthritis. J Clin Periodontol 46(7):690\u2013698","journal-title":"J Clin Periodontol"},{"issue":"6","key":"12_CR69","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.chom.2014.05.012","volume":"15","author":"T Maekawa","year":"2014","unstructured":"Maekawa T et al (2014) Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. Cell Host Microbe 15(6):768\u2013778","journal-title":"Cell Host Microbe"},{"key":"12_CR70","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fcimb.2017.00359","volume":"7","author":"H Makkawi","year":"2017","unstructured":"Makkawi H et al (2017) Porphyromonas gingivalis stimulates TLR2-PI3K signaling to escape immune clearance and induce bone resorption independently of MyD88. Front Cell Infect Microbiol 7:359","journal-title":"Front Cell Infect Microbiol"},{"key":"12_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar3000","volume":"12","author":"P Mangat","year":"2010","unstructured":"Mangat P et al (2010) Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther 12:1\u20139","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"12_CR72","doi-asserted-by":"publisher","first-page":"e195394","DOI":"10.1001\/jamanetworkopen.2019.5394","volume":"2","author":"K Mankia","year":"2019","unstructured":"Mankia K et al (2019) Prevalence of periodontal disease and periodontopathic bacteria in anti\u2013cyclic citrullinated protein antibody\u2013positive at-risk adults without arthritis. JAMA Netw Open 2(6):e195394","journal-title":"JAMA Netw Open"},{"key":"12_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.921675","volume":"9","author":"M Marazzato","year":"2022","unstructured":"Marazzato M et al (2022) Gut microbiota structure and metabolites, before and after treatment in early rheumatoid arthritis patients: a pilot study. Front Med 9:921675","journal-title":"Front Med"},{"issue":"9","key":"12_CR74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003627","volume":"9","author":"KJ Maresz","year":"2013","unstructured":"Maresz KJ et al (2013) Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog 9(9):e1003627","journal-title":"PLoS Pathog"},{"issue":"12","key":"12_CR75","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/j.1600-051X.2009.01496.x","volume":"36","author":"RE Martinez-Martinez","year":"2009","unstructured":"Martinez-Martinez RE et al (2009) Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol 36(12):1004\u20131010","journal-title":"J Clin Periodontol"},{"key":"12_CR76","volume-title":"Seminars in immunopathology","author":"K Matsuoka","year":"2015","unstructured":"Matsuoka K, Kanai T (2015) The gut microbiota and inflammatory bowel disease. In: Seminars in immunopathology. Springer"},{"issue":"7","key":"12_CR77","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1128\/IAI.67.7.3248-3256.1999","volume":"67","author":"WT McGraw","year":"1999","unstructured":"McGraw WT et al (1999) Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 67(7):3248\u20133256","journal-title":"Infect Immun"},{"issue":"5","key":"12_CR78","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1136\/annrheumdis-2020-219009","volume":"80","author":"R Moentadj","year":"2021","unstructured":"Moentadj R et al (2021) Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice. Ann Rheum Dis 80(5):573\u2013581","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"12_CR79","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1136\/annrheumdis-2015-207656","volume":"75","author":"AB Montgomery","year":"2016","unstructured":"Montgomery AB et al (2016) Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis. Ann Rheum Dis 75(6):1255\u20131261","journal-title":"Ann Rheum Dis"},{"key":"12_CR80","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s10266-020-00566-0","volume":"109","author":"MF Moura","year":"2021","unstructured":"Moura MF et al (2021) Clinical and microbiological effects of non-surgical periodontal treatment in individuals with rheumatoid arthritis: a controlled clinical trial. Odontology 109:484\u2013493","journal-title":"Odontology"},{"key":"12_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-018-1744-3","volume":"20","author":"S Munenaga","year":"2018","unstructured":"Munenaga S et al (2018) The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice. Arthritis Res Ther 20:1\u201312","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"12_CR82","first-page":"476068","volume":"2014","author":"J Mysak","year":"2014","unstructured":"Mysak J et al (2014) Porphyromonas gingivalis: major periodontopathic pathogen overview. J Immunol Res 2014(1):476068","journal-title":"J Immunol Res"},{"issue":"1","key":"12_CR83","doi-asserted-by":"publisher","first-page":"15789","DOI":"10.1038\/s41598-017-16190-y","volume":"7","author":"B Nativel","year":"2017","unstructured":"Nativel B et al (2017) Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human. Sci Rep 7(1):15789","journal-title":"Sci Rep"},{"issue":"1","key":"12_CR84","doi-asserted-by":"publisher","first-page":"97","DOI":"10.17219\/dmp\/131266","volume":"58","author":"VB Nguyen","year":"2021","unstructured":"Nguyen VB et al (2021) Effects of non-surgical periodontal treatment in rheumatoid arthritis patients: a randomized clinical trial. Dent Med Probl 58(1):97\u2013105","journal-title":"Dent Med Probl"},{"issue":"2","key":"12_CR85","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/art.20018","volume":"50","author":"MM Nielen","year":"2004","unstructured":"Nielen MM et al (2004) Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 50(2):380\u2013386","journal-title":"Arthritis Rheum"},{"issue":"12","key":"12_CR86","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1902\/jop.2013.130079","volume":"84","author":"M Okada","year":"2013","unstructured":"Okada M et al (2013) Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis. J Periodontol 84(12):e74\u2013e84","journal-title":"J Periodontol"},{"issue":"1","key":"12_CR87","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.femsre.2004.09.001","volume":"29","author":"T Olczak","year":"2005","unstructured":"Olczak T et al (2005) Iron and heme utilization in Porphyromonas gingivalis. FEMS Microbiol Rev 29(1):119\u2013144","journal-title":"FEMS Microbiol Rev"},{"issue":"4","key":"12_CR88","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1902\/jop.2009.080447","volume":"80","author":"P Ortiz","year":"2009","unstructured":"Ortiz P et al (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80(4):535\u2013540","journal-title":"J Periodontol"},{"issue":"1","key":"12_CR89","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1600-0757.2012.00453.x","volume":"64","author":"RJ Palmer Jr","year":"2000","unstructured":"Palmer RJ Jr (2000) Composition and development of oral bacterial communities. Periodontology 64(1):20\u201339","journal-title":"Periodontology"},{"issue":"7","key":"12_CR90","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/cmi.12308","volume":"16","author":"C Petersen","year":"2014","unstructured":"Petersen C, Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024\u20131033","journal-title":"Cell Microbiol"},{"issue":"9499","key":"12_CR91","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366(9499):1809\u20131820","journal-title":"Lancet"},{"issue":"6","key":"12_CR92","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1902\/jop.2008.070501","volume":"79","author":"N Pischon","year":"2008","unstructured":"Pischon N et al (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 79(6):979\u2013986","journal-title":"J Periodontol"},{"issue":"11","key":"12_CR93","doi-asserted-by":"publisher","first-page":"7242","DOI":"10.4049\/jimmunol.178.11.7242","volume":"178","author":"K Popadiak","year":"2007","unstructured":"Popadiak K et al (2007) Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol 178(11):7242\u20137250","journal-title":"J Immunol"},{"issue":"10","key":"12_CR94","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"J Potempa","year":"2017","unstructured":"Potempa J, Mydel P, Koziel J (2017) The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol 13(10):606\u2013620","journal-title":"Nat Rev Rheumatol"},{"issue":"7285","key":"12_CR95","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J Qin","year":"2010","unstructured":"Qin J et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285):59\u201365","journal-title":"Nature"},{"issue":"10","key":"12_CR96","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S Rantap\u00e4\u00e4-Dahlqvist","year":"2003","unstructured":"Rantap\u00e4\u00e4-Dahlqvist S et al (2003) Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 48(10):2741\u20132749","journal-title":"Arthritis Rheum"},{"issue":"6","key":"12_CR97","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/jcpe.12102","volume":"40","author":"S Reichert","year":"2013","unstructured":"Reichert S et al (2013) Detection of oral bacterial DNA in synovial fluid. J Clin Periodontol 40(6):591\u2013598","journal-title":"J Clin Periodontol"},{"key":"12_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-019-1808-z","volume":"21","author":"B Rodr\u00edguez-Lozano","year":"2019","unstructured":"Rodr\u00edguez-Lozano B et al (2019) Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case\u2013control study. Arthritis Res Ther 21:1\u201312","journal-title":"Arthritis Res Ther"},{"issue":"209","key":"12_CR99","doi-asserted-by":"publisher","first-page":"209ra150","DOI":"10.1126\/scitranslmed.3006869","volume":"5","author":"V Romero","year":"2013","unstructured":"Romero V et al (2013) Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci Transl Med 5(209):209ra150","journal-title":"Sci Transl Med"},{"key":"12_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-016-1014-1","volume":"18","author":"K Roos","year":"2016","unstructured":"Roos K et al (2016) Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking. Arthritis Res Ther 18:1\u20139","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"12_CR101","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/0022034517742139","volume":"97","author":"B Rosier","year":"2018","unstructured":"Rosier B, Marsh P, Mira A (2018) Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis. J Dent Res 97(4):371\u2013380","journal-title":"J Dent Res"},{"issue":"10","key":"12_CR102","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1002\/art.34539","volume":"64","author":"JU Scher","year":"2012","unstructured":"Scher JU et al (2012) Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 64(10):3083\u20133094","journal-title":"Arthritis Rheum"},{"issue":"4","key":"12_CR103","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1902\/jop.2016.160355","volume":"88","author":"J Schmickler","year":"2017","unstructured":"Schmickler J et al (2017) Cross-sectional evaluation of periodontal status and microbiologic and rheumatoid parameters in a large cohort of patients with rheumatoid arthritis. J Periodontol 88(4):368\u2013379","journal-title":"J Periodontol"},{"issue":"3","key":"12_CR104","doi-asserted-by":"publisher","first-page":"2350776","DOI":"10.1002\/eji.202350776","volume":"54","author":"A Schuster","year":"2024","unstructured":"Schuster A et al (2024) Gingival fibroblast activation by Porphyromonas gingivalis is driven by TLR2 and is independent of the LPS-TLR4 axis. Eur J Immunol 54(3):2350776","journal-title":"Eur J Immunol"},{"issue":"12","key":"12_CR105","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1002\/art.40227","volume":"69","author":"A Schwenzer","year":"2017","unstructured":"Schwenzer A et al (2017) Association of distinct fine specificities of anti\u2212 citrullinated peptide antibodies with elevated immune responses to Prevotella intermedia in a subgroup of patients with rheumatoid arthritis and periodontitis. Arthritis Rheum 69(12):2303\u20132313","journal-title":"Arthritis Rheum"},{"issue":"8","key":"12_CR106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533","volume":"14","author":"R Sender","year":"2016","unstructured":"Sender R, Fuchs S, Milo R (2016) Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14(8):e1002533","journal-title":"PLoS Biol"},{"issue":"5","key":"12_CR107","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrrheum.2015.8","volume":"11","author":"JS Smolen","year":"2015","unstructured":"Smolen JS, Aletaha D (2015) Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 11(5):276\u2013289","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"12_CR108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035296","volume":"7","author":"J Sokolove","year":"2012","unstructured":"Sokolove J et al (2012) Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS One 7(5):e35296","journal-title":"PLoS One"},{"issue":"5","key":"12_CR109","doi-asserted-by":"publisher","first-page":"e01704","DOI":"10.1128\/mBio.01704-18","volume":"9","author":"T Stobernack","year":"2018","unstructured":"Stobernack T et al (2018) A secreted bacterial peptidylarginine deiminase can neutralize human innate immune defenses. MBio 9(5):e01704\u2013e01718","journal-title":"MBio"},{"key":"12_CR110","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jaut.2015.03.002","volume":"59","author":"C Terao","year":"2015","unstructured":"Terao C et al (2015) Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population\u2013the Nagahama study. J Autoimmun 59:85\u201390","journal-title":"J Autoimmun"},{"issue":"6","key":"12_CR111","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.identj.2022.04.008","volume":"72","author":"S Thilagar","year":"2022","unstructured":"Thilagar S et al (2022) Periodontal treatment for chronic periodontitis with rheumatoid arthritis. Int Dent J 72(6):832\u2013838","journal-title":"Int Dent J"},{"issue":"6","key":"12_CR112","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.chembiol.2018.03.002","volume":"25","author":"R Tilvawala","year":"2018","unstructured":"Tilvawala R et al (2018) The rheumatoid arthritis-associated citrullinome. Cell Chem Biol 25(6):691\u2013704. e6","journal-title":"Cell Chem Biol"},{"issue":"5","key":"12_CR113","doi-asserted-by":"publisher","first-page":"A288","DOI":"10.1016\/j.autrev.2009.11.019","volume":"9","author":"GJ Tob\u00f3n","year":"2010","unstructured":"Tob\u00f3n GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. Autoimmun Rev 9(5):A288\u2013A292","journal-title":"Autoimmun Rev"},{"issue":"6","key":"12_CR114","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1399-302X.2006.00307.x","volume":"21","author":"H Uematsu","year":"2006","unstructured":"Uematsu H et al (2006) Degradation of arginine by Slackia exigua ATCC 700122 and Cryptobacterium curtum ATCC 700683. Oral Microbiol Immunol 21(6):381\u2013384","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"12_CR115","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/art.37720","volume":"65","author":"JJ van Beers","year":"2013","unstructured":"van Beers JJ et al (2013) The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and \u03b2-actin. Arthritis Rheum 65(1):69\u201380","journal-title":"Arthritis Rheum"},{"issue":"9","key":"12_CR116","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3390\/toxins11090489","volume":"11","author":"BA Vega","year":"2019","unstructured":"Vega BA, Belinka BA Jr, Kachlany SC (2019) Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera\u00ae): mechanisms of action and therapeutic applications. Toxins 11(9):489","journal-title":"Toxins"},{"issue":"6","key":"12_CR117","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1177\/0961203313501401","volume":"23","author":"SM Vieira","year":"2014","unstructured":"Vieira SM, Pagovich OE, Kriegel MA (2014) Diet, microbiota and autoimmune diseases. Lupus 23(6):518\u2013526","journal-title":"Lupus"},{"issue":"11","key":"12_CR118","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/bies.10357","volume":"25","author":"ER Vossenaar","year":"2003","unstructured":"Vossenaar ER et al (2003) PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. BioEssays 25(11):1106\u20131118","journal-title":"BioEssays"},{"issue":"1","key":"12_CR119","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/prd.12365","volume":"86","author":"WG Wade","year":"2000","unstructured":"Wade WG (2000) Resilience of the oral microbiome. Periodontology 86(1):113\u2013122","journal-title":"Periodontology"},{"issue":"7","key":"12_CR120","first-page":"447","volume":"44","author":"W Wade","year":"2016","unstructured":"Wade W et al (2016) Uncultured members of the oral microbiome. J Calif Dent Assoc 44(7):447\u2013456","journal-title":"J Calif Dent Assoc"},{"issue":"109","key":"12_CR121","doi-asserted-by":"publisher","first-page":"ra11-ra11","DOI":"10.1126\/scisignal.2000697","volume":"3","author":"M Wang","year":"2010","unstructured":"Wang M et al (2010) Microbial hijacking of complement\u2013toll-like receptor crosstalk. Sci Signal 3(109):ra11-ra11","journal-title":"Sci Signal"},{"key":"12_CR122","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s10067-016-3247-4","volume":"35","author":"F Wang","year":"2016","unstructured":"Wang F et al (2016) Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF\/TOF. Clin Rheumatol 35:2185\u20132194","journal-title":"Clin Rheumatol"},{"issue":"9","key":"12_CR123","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1002\/art.27552","volume":"62","author":"N Wegner","year":"2010","unstructured":"Wegner N et al (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and \u03b1-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62(9):2662\u20132672","journal-title":"Arthritis Rheum"},{"key":"12_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.823685","volume":"13","author":"A Wielento","year":"2022","unstructured":"Wielento A et al (2022) TLR2 activation by Porphyromonas gingivalis requires both PPAD activity and fimbriae. Front Immunol 13:823685","journal-title":"Front Immunol"},{"issue":"4","key":"12_CR125","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/omi.12427","volume":"38","author":"A Wielento","year":"2023","unstructured":"Wielento A et al (2023) Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis. Mol Oral Microbiol 38(4):334\u2013346","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"12_CR126","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","volume":"22","author":"E Xiao","year":"2017","unstructured":"Xiao E et al (2017) Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host Microbe 22(1):120\u2013128. e4","journal-title":"Cell Host Microbe"},{"key":"12_CR127","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.763507","volume":"11","author":"D Yu","year":"2022","unstructured":"Yu D et al (2022) The gut microbiome and metabolites are altered and interrelated in patients with rheumatoid arthritis. Front Cell Infect Microbiol 11:763507","journal-title":"Front Cell Infect Microbiol"},{"key":"12_CR128","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2023-eular.5328","volume-title":"POS0442 endocitrullination of RA autoantigens is more abundant than C-terminal citrullination in the gingival crevicular fluid of anti-CCP positive at-risk individuals with periodontal disease but no synovitis","author":"X Yu","year":"2023","unstructured":"Yu X et al (2023) POS0442 endocitrullination of RA autoantigens is more abundant than C-terminal citrullination in the gingival crevicular fluid of anti-CCP positive at-risk individuals with periodontal disease but no synovitis. BMJ Publishing Group Ltd"},{"issue":"1","key":"12_CR129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-9-259","volume":"9","author":"E Zaura","year":"2009","unstructured":"Zaura E et al (2009) Defining the healthy. BMC Microbiol 9(1):1\u201312","journal-title":"BMC Microbiol"},{"issue":"8","key":"12_CR130","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","volume":"21","author":"X Zhang","year":"2015","unstructured":"Zhang X et al (2015) The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med 21(8):895\u2013905","journal-title":"Nat Med"},{"issue":"1","key":"12_CR131","doi-asserted-by":"publisher","first-page":"14305","DOI":"10.1038\/s41598-018-32675-w","volume":"8","author":"Y Zhao","year":"2018","unstructured":"Zhao Y et al (2018a) Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients. Sci Rep 8(1):14305","journal-title":"Sci Rep"},{"key":"12_CR132","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.12659\/MSM.909117","volume":"24","author":"X Zhao","year":"2018","unstructured":"Zhao X et al (2018b) Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit 24:5802","journal-title":"Med Sci Monit"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Microbiome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-79146-8_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T18:26:01Z","timestamp":1742667961000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-79146-8_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031791451","9783031791468"],"references-count":132,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-79146-8_12","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"21 March 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}