{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:06:44Z","timestamp":1789330004068,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":96,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031803956","type":"print"},{"value":"9783031803963","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-80396-3_10","type":"book-chapter","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:00:10Z","timestamp":1742356810000},"page":"247-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical Treatment of Medullary Thyroid Cancer"],"prefix":"10.1007","author":[{"given":"Andreas","family":"Machens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Dralle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1089\/thy.2005.15.618","volume":"15","author":"SLS Barbosa","year":"2005","unstructured":"Barbosa SLS, Rodien P, Leboulleux S, Niccoli-Sire P, Kraimps JL, Caron P, Archambeaud-Mouveroux F, Conte-Devolx B, Rohmer V, Groupe d\u2019Etude des Tumeurs Endocrines (2005) Ectopic adrenocortico-tropic hormone-syndrome in medullary carcinoma of the thyroid: a retrospective analysis and review of the literature. Thyroid 15:618\u2013623","journal-title":"Thyroid"},{"key":"10_CR2","first-page":"158","volume":"10","author":"T Billroth","year":"1869","unstructured":"Billroth T (1869) Chirurgische Erfahrungen. Z\u00fcrich 1860\u20131867. Langenbecks Arch Klin Chir 10:158\u2013171","journal-title":"Langenbecks Arch Klin Chir"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182a6f43a","volume":"259","author":"M Brauckhoff","year":"2014","unstructured":"Brauckhoff M, Machens A, Lorenz K, Bj\u00f8ro T, Varhaug JE, Dralle H (2014) Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2B: a changing perspective. Ann Surg 259:800\u2013806","journal-title":"Ann Surg"},{"key":"10_CR4","unstructured":"Burk W (1901) \u00dcber einen Amyloidtumor mit Metastasen. Inaugural-Dissertation, T\u00fcbingen"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1210\/jc.2014-4508","volume":"100","author":"MG Castagna","year":"2015","unstructured":"Castagna MG, Fugazzola L, Maino F, Covelli D, Memmo S, Sestini F, Fioravanti C, Ferraris Fusarini C, Scapellato C, Macchini F, Cevenini G, Pacini F (2015) Reference range of serum calcitonin in pediatric population. J Clin Endocrinol Metab 100:1780\u20131784","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1089\/thy.2020.0674","volume":"31","author":"F Castinetti","year":"2021","unstructured":"Castinetti F, Ta\u00efeb D (2021) Positron emission tomography imaging in medullary thyroid carcinoma: time for reappraisal? Thyroid 31:151\u2013155","journal-title":"Thyroid"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S2213-8587(18)30336-X","volume":"7","author":"F Castinetti","year":"2019","unstructured":"Castinetti F, Waguespack SG, Machens A, Uchino S, Hasse-Lazar K, Sanso G, Else T, Dvorakova S, Qi XP, Elisei R, Maia AL, Glod J, Louren\u00e7o DM Jr, Valdes N, Mathiesen J, Wohllk N, Bandgar TR, Drui D, Korbonits M, Druce MR, Brain C, Kurzawinski T, Patocs A, Bugalho MJ, Lacroix A, Caron P, Fainstein-Day P, Borson Chazot F, Klein M, Links TP, Letizia C, Fugazzola L, Chabre O, Canu L, Cohen R, Tabarin A, Spehar Uroic A, Maiter D, Laboureau S, Mian C, Peczkowska M, Sebag F, Brue T, Mirebeau-Prunier D, Leclerc L, Bausch B, Berdelou A, Sukurai A, Vlcek P, Krajewska J, Barontini M, Vaz Ferreira Vargas C, Valerio L, Ceolin L, Akshintala S, Hoff A, Godballe C, Jarzab B, Jimenez C, Eng C, Imai T, Schlumberger M, Grubbs E, Dralle H, Neumann HP, Baudin E (2019) Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol 7:213\u2013220","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1097\/00000658-199806000-00012","volume":"227","author":"H Chen","year":"1998","unstructured":"Chen H, Roberts JR, Ball DW, Eisele DW, Baylin SB, Udelsman R, Bulkley GB (1998) Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection. Ann Surg 227:887\u2013895","journal-title":"Ann Surg"},{"key":"10_CR9","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1210\/endo-70-5-638","volume":"70","author":"DH Copp","year":"1962","unstructured":"Copp DH (1962) Evidence for calcitonin: new hormone from parathyroid that lowers blood calcium. Endocrinology 70:638\u2013649","journal-title":"Endocrinology"},{"key":"10_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1093\/hmg\/2.7.851","volume":"7","author":"H Donis-Keller","year":"1993","unstructured":"Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow P, Wells SA (1993) Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet 7:851\u2013856","journal-title":"Hum Mol Genet"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1046\/j.1365-2168.2002.02160.x","volume":"89","author":"H Dralle","year":"2002","unstructured":"Dralle H (2002) Lymph node dissection and medullary thyroid carcinoma. Br J Surg 89:1073\u20131075","journal-title":"Br J Surg"},{"key":"10_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/CCO.0b013e328359ff1f","volume":"25","author":"H Dralle","year":"2013","unstructured":"Dralle H, Machens A (2013) Surgical management of the lateral neck compartment for metastatic thyroid cancer. Curr Opin Oncol 25:20\u201326","journal-title":"Curr Opin Oncol"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/BF02473391","volume":"24","author":"H Dralle","year":"1994","unstructured":"Dralle H, Damm I, Scheumann GFW, Kotzerke J, Kupsch E, Geerlings H, Pichlmayr R (1994) Compartment-oriented microdissection of regional lymph nodes in medullary thyroid carcinoma. Surg Today 24:112\u2013121","journal-title":"Surg Today"},{"key":"10_CR14","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s002689900463","volume":"22","author":"H Dralle","year":"1998","unstructured":"Dralle H, Gimm O, Simon D, Frank-Raue K, G\u00f6rtz G, Niederle B, Wahl RA, Koch B, Walgenbach S, Hampel R, Ritter MM, Spelsberg F, Heiss A, Hinze R, H\u00f6ppner W (1998) Prophylactic thyroidectomy in 75 children and adolescents with hereditary medullary thyroid carcinoma\u2014the German and Austrian experience. World J Surg 22:744\u2013751","journal-title":"World J Surg"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00423-013-1057-6","volume":"398","author":"H Dralle","year":"2013","unstructured":"Dralle H, Musholt TJ, Schabram J, Steinm\u00fcller T, Frilling A, Simon D, Goretzki PE, Niderle B, Scheuba C, Clerici T, Hermann M, Ku\u00dfmann J, Lorenz K, Nies C, Schabram P, Trupka A, Zielke A, Karges W, Luster M, Schmid KW, Vordermark D, Schmoll HJ, M\u00fchlenberg R, Schober O, Rimmele H, Machens A, for the German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hematology; and the German Thyroid Cancer Patient Support Organization (2013) German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors. Langenbeck\u2019s Arch Surg 398:347\u2013375","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"10_CR16","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.surg.2023.09.003","volume":"174","author":"H Dralle","year":"2023","unstructured":"Dralle H, Brandenburg T, Weber F, F\u00fchrer-Sakel D, Theurer S, Baba HA, Schmid KW, Machens A (2023) Sporadic noninvasive medullary thyroid neoplasm: a desmoplasia-negative, unifocal, nonmetastatic tumor, cured by hemithyroidectomy. Surgery 174:1356\u20131362","journal-title":"Surgery"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1089\/thy.2022.0295","volume":"33","author":"MADS Duval","year":"2023","unstructured":"Duval MADS, Ferreira CV, Marmitt L, Dora JM, Esp\u00edndola M, Benini AF, Camelier MV, Bulzico D, Andrade FA, Alves J\u00fanior PA, Corbo R, Vaisman F, Zanella AB, Scheffel RS, Maia AL (2023) An undetectable postoperative calcitonin level is associated with long-term disease-free survival in medullary thyroid carcinoma: results of a retrospective cohort study. Thyroid 33:82\u201390","journal-title":"Thyroid"},{"key":"10_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1210\/jc.2003-030550","volume":"89","author":"R Elisei","year":"2004","unstructured":"Elisei R, Bottici V, Luchetti F, Di Coscio G, Romei C, Grasso L, Miccoli P, Iacconi P, Basolo F, Pinchera A, Pacini F (2004) Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorder. J Clin Endocrinol Metab 89:163\u2013168","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR19","doi-asserted-by":"crossref","unstructured":"Elisei R, Alevizaki M, Conte-Devolx B, Frank-Raue K, Leite V, Williams GR (2012a) 2012 European thyroid association guidelines for genetic testing and its clinical consequences in medullary thyroid cancer. Eur Thyroid J 1:216\u2013231","DOI":"10.1159\/000346174"},{"key":"10_CR20","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1210\/jc.2011-2046","volume":"97","author":"R Elisei","year":"2012","unstructured":"Elisei R, Romei C, Renzini G, Bottici V, Cosci B, Molinaro E, Agate L, Cappagli V, Miccoli P, Berti P, Faviana P, Ugolini C, Basolo F, Vitti P, Pinchera A (2012b) The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center. J Clin Endocrinol Metab 97:426\u2013435","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1210\/jc.2013-2942","volume":"99","author":"NH Esfandiari","year":"2014","unstructured":"Esfandiari NH, Hughes DT, Yin H, Banerjee M, Haymart MR (2014) The effect of extent of surgery and number of lymph node metastases on overall survival in patients with medullary thyroid cancer. J Clin Endocrinol Metab 99:448\u2013454","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1093\/bjs\/znab106","volume":"108","author":"F Fanget","year":"2021","unstructured":"Fanget F, Demarchi MS, Maillard L, Lintis A, Decaussin M, Lifante JC (2021) Medullary thyroid cancer outcomes in patients with undetectable versus normalized postoperative calcitonin levels. Br J Surg 108:1064\u20131071","journal-title":"Br J Surg"},{"key":"10_CR23","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/2021303a0","volume":"202","author":"GV Foster","year":"1964","unstructured":"Foster GV, McIntyre I, Pearse AGE (1964) Thyroid origin of calcitonin. Nature 202:1303\u20131305","journal-title":"Nature"},{"key":"10_CR24","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1089\/thy.2012.0236","volume":"23","author":"K Frank-Raue","year":"2013","unstructured":"Frank-Raue K, Machens A, Leidig-Bruckner G, Rondot S, Haag C, Schulze E, Lorenz A, Kreissl MC, Dralle H, Raue F, Schmid KW (2013) Prevalence and clinical spectrum of nonsecretory medullary thyroid carcinoma in a series of 839 patients with sporadic medullary thyroid carcinoma. Thyroid 23:294\u2013300","journal-title":"Thyroid"},{"key":"10_CR25","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1210\/clinem\/dgab300","volume":"106","author":"L Giovanella","year":"2021","unstructured":"Giovanella L, Garo ML, Ceriani L, Paone G, Campenni\u2019 A, D\u2019Aurizio F (2021) Procalcitonin as an alternative tumor marker of medullary thyroid carcinoma. J Clin Endocrinol Metab 106:3634\u20133643","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR26","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1210\/jc.2007-1211","volume":"92","author":"AL Giraudet","year":"2007","unstructured":"Giraudet AL, Vanel D, Leboulleux S, Aup\u00e9rin A, Dromain C, Chami L, Ny Tovo N, Lumbroso J, Lassau N, Bonniaud G, Hartl D, Travagli JP, Baudin E, Schlumberger M (2007) Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 92:4185\u20134190","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR27","first-page":"184","volume":"1","author":"E Gurlt","year":"1861","unstructured":"Gurlt E (1861) Bericht \u00fcber die Leistungen und Fortschritte auf dem Gebiet der Chirurgie im Jahre 1859. Langenbecks Arch Klin Chir 1:184\u2013187","journal-title":"Langenbecks Arch Klin Chir"},{"key":"10_CR28","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1210\/jcem-19-1-152","volume":"19","author":"JB Hazard","year":"1959","unstructured":"Hazard JB, Hawk WA, Crile G (1959) Medullary (solid) carcinoma of the thyroid, a clinicopathologic entity. J Clin Endocrinol Metab 19:152\u2013161","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR29","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/1097-0142(195107)4:4<697::AID-CNCR2820040407>3.0.CO;2-8","volume":"4","author":"RC Horn","year":"1951","unstructured":"Horn RC (1951) Carcinoma of the thyroid. Description of a distinctive morphological variant and report of seven cases. Cancer 4:697\u2013707","journal-title":"Cancer"},{"key":"10_CR30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF01948712","volume":"185","author":"J Jacquet","year":"1906","unstructured":"Jacquet J (1906) Ein Fall von metastasierenden Amyloidtumoren (Lymphosarkom). Virchows Arch 185:251\u2013268","journal-title":"Virchows Arch"},{"key":"10_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-2004-815727","volume":"112","author":"W Karges","year":"2004","unstructured":"Karges W, Dralle H, Raue F, Mann K, Reiners C, Grussendorf M, H\u00fcfner M, Niederle B, Brabant G, German Society for Endocrinology (DGE)\u2014Thyroid Section (2004) Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation. Exp Clin Endocrinol Diabetes 112:52\u201358","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10_CR34","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1056\/NEJM199409293311302","volume":"331","author":"C Lips","year":"1994","unstructured":"Lips C, Landsvater RM, Hoppener J, Geerdink RA, Blijham G, van Veen JMJS, van Gils A, de Wit MJ, Zewald RA, Berends M, Beemer FA, Brouwers-Smalbraak J, Jansen R, van Amstel HKP, van Vroonhoven T, Vroom TM (1994) Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A. N Engl J Med 331:828\u2013835","journal-title":"N Engl J Med"},{"key":"10_CR36","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00423-010-0686-2","volume":"395","author":"K Lorenz","year":"2010","unstructured":"Lorenz K, Abuazab M, Sekulla C, Nguyen Thanh P, Brauckhoff M, Dralle H (2010) Management of lymph fistulas in thyroid surgery. Langenbeck\u2019s Arch Surg 395:911\u2013917","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"10_CR37","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1210\/jc.2009-2368","volume":"95","author":"A Machens","year":"2010","unstructured":"Machens A, Dralle H (2010) Biomarker-based risk stratification for previously untreated medullary thyroid cancer. J Clin Endocrinol Metab 95:2655\u20132663","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR38","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/SLA.0b013e318268301d","volume":"257","author":"A Machens","year":"2013","unstructured":"Machens A, Dralle H (2013a) Prognostic impact of N staging in 715 medullary thyroid cancer patients: proposal for a revised staging system. Ann Surg 257:323\u2013329","journal-title":"Ann Surg"},{"key":"10_CR39","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/SLA.0b013e31826bc239","volume":"257","author":"A Machens","year":"2013","unstructured":"Machens A, Dralle H (2013b) Benefit-risk balance of reoperation for persistent medullary thyroid cancer. Ann Surg 257:751\u2013757","journal-title":"Ann Surg"},{"key":"10_CR40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1530\/EJE-16-0325","volume":"175","author":"A Machens","year":"2016","unstructured":"Machens A, Dralle H (2016) Surgical cure rates of sporadic medullary thyroid cancer in the era of calcitonin screening. Eur J Endocrinol 175:219\u2013228","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10_CR41","doi-asserted-by":"publisher","first-page":"K43","DOI":"10.1093\/ejendo\/lvae025","volume":"90","author":"A Machens","year":"2024","unstructured":"Machens A, Dralle H (2024) Accelerated MEN2A in homozygous RET carriers in the context of consanguinity. Eur J Endocrinol 90(3):K43\u2013K46. https:\/\/doi.org\/10.1093\/ejendo\/lvae025","journal-title":"Eur J Endocrinol"},{"key":"10_CR42","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s004230050203","volume":"384","author":"A Machens","year":"1999","unstructured":"Machens A, Gimm O, Ukkat J, Sutter T, Dralle H (1999) Repeat mediastinal lymph node dissection for palliation in advanced medullary thyroid carcinoma. Langenbeck\u2019s Arch Surg 384:271\u2013286","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"10_CR43","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s004230100226","volume":"386","author":"A Machens","year":"2001","unstructured":"Machens A, Hinze R, Dralle H (2001a) Surgery on the cervicovisceral axis for invasive thyroid cancer. Langenbeck\u2019s Arch Surg 386:318\u2013323","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"10_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1067\/msy.2001.108699","volume":"129","author":"A Machens","year":"2001","unstructured":"Machens A, Hinze R, Lautenschl\u00e4ger C, Thomusch O, Dralle H (2001b) Thyroid carcinoma invading the cervicovisceral axis: routes of invading and clinical implications. Surgery 129:23\u201328","journal-title":"Surgery"},{"key":"10_CR45","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1056\/NEJMoa012915","volume":"349","author":"A Machens","year":"2003","unstructured":"Machens A, Niccoli-Sire P, Hoegel J, Frank-Raue K, van Vroonhoven TJ, Roeher HD, Wahl RA, Lamesch P, Raue F, Conte-Devolx B, Dralle H, for the European Multiple Endocrine Neoplasia (EUROMEN) Study Group (2003) Early malignant progression of hereditary medullary thyroid cancer. N Engl J Med 349:1517\u20131523","journal-title":"N Engl J Med"},{"key":"10_CR46","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1002\/bjs.4525","volume":"91","author":"A Machens","year":"2004","unstructured":"Machens A, Holzhausen HJ, Dralle H (2004) Prediction of mediastinal lymph node metastasis in medullary thyroid carcinoma. Br J Surg 91:709\u2013712","journal-title":"Br J Surg"},{"key":"10_CR47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1001\/archsurg.142.3.289","volume":"142","author":"A Machens","year":"2007","unstructured":"Machens A, Ukkat J, Hauptmann S, Dralle H (2007) Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis. Arch Surg 142:289\u2013293; discussion 294","journal-title":"Arch Surg"},{"key":"10_CR48","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1677\/ERC-09-0136","volume":"16","author":"A Machens","year":"2009","unstructured":"Machens A, Hoffmann F, Sekulla C, Dralle H (2009a) Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer. Endocr Relat Cancer 16:1291\u20131298","journal-title":"Endocr Relat Cancer"},{"key":"10_CR49","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/SLA.0b013e3181ae333f","volume":"250","author":"A Machens","year":"2009","unstructured":"Machens A, Lorenz K, Dralle H (2009b) Individualization of lymph node dissection in RET (rearranged during transfection) carriers at risk for medullary thyroid cancer. Ann Surg 250:305\u2013310","journal-title":"Ann Surg"},{"key":"10_CR50","doi-asserted-by":"publisher","first-page":"E336","DOI":"10.1210\/jc.2012-3192","volume":"98","author":"A Machens","year":"2013","unstructured":"Machens A, Lorenz K, Dralle H (2013) Peak incidence of pheochromocytoma and primary hyperparathyroidism in multiple endocrine neoplasia 2: need for age-adjusted biochemical screening. J Clin Endocinol Metab 98:E336\u2013E345","journal-title":"J Clin Endocinol Metab"},{"key":"10_CR51","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1210\/jc.2014-1278","volume":"99","author":"A Machens","year":"2014","unstructured":"Machens A, Lorenz K, Dralle H (2014) Utility of serum procalcitonin for screening and risk stratification of medullary thyroid cancer. J Clin Endocinol Metab 99:2986\u20132994","journal-title":"J Clin Endocinol Metab"},{"key":"10_CR52","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1002\/bjs.10746","volume":"105","author":"A Machens","year":"2018","unstructured":"Machens A, Elwerr M, Lorenz K, Weber F, Dralle H (2018a) Long-term outcome of prophylactic thyroidectomy in children carrying RET germline mutations. Br J Surg 105:e150\u2013e157","journal-title":"Br J Surg"},{"key":"10_CR53","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s12020-018-1625-1","volume":"61","author":"A Machens","year":"2018","unstructured":"Machens A, Lorenz K, Dralle H (2018b) Histology-proven recurrence in the lateral or central neck after systematic neck dissection for medullary thyroid cancer. Endocrine 61:428\u2013439","journal-title":"Endocrine"},{"key":"10_CR54","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/humu.23430","volume":"39","author":"A Machens","year":"2018","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2018c) Genotype-specific progression of hereditary medullary thyroid cancer. Hum Mutat 39:860\u2013869","journal-title":"Hum Mutat"},{"key":"10_CR55","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/bjs.11071","volume":"106","author":"A Machens","year":"2019","unstructured":"Machens A, Lorenz K, Dralle H (2019) Time to calcitonin normalization after surgery for node-negative and node-positive medullary thyroid cancer. Br J Surg 106:412\u2013418","journal-title":"Br J Surg"},{"key":"10_CR56","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/bjs.11444","volume":"107","author":"A Machens","year":"2020","unstructured":"Machens A, Lorenz K, Dralle H (2020) Prediction of biochemical cure in patients with medullary thyroid cancer. Br J Surg 107:695\u2013704","journal-title":"Br J Surg"},{"key":"10_CR57","doi-asserted-by":"publisher","first-page":"e2968","DOI":"10.1210\/clinem\/dgab214","volume":"106","author":"A Machens","year":"2021","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2021a) Exceptionality of distant metastasis in node-negative hereditary and sporadic medullary thyroid cancer: lessons learned. J Clin Endocrinol Metab 106:e2968\u2013e2979","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR58","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.ejso.2020.09.004","volume":"47","author":"A Machens","year":"2021","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2021b) Lymph node metastasis in hereditary medullary thyroid cancer is independent of the underlying RET germline mutation. Eur J Surg Oncol 47:920\u2013923","journal-title":"Eur J Surg Oncol"},{"key":"10_CR59","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.ejso.2020.11.006","volume":"47","author":"A Machens","year":"2021","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2021c) Prophylactic neck surgery for second-generation multiple endocrine neoplasia type 2B. Eur J Surg Oncol 47:924\u2013927","journal-title":"Eur J Surg Oncol"},{"key":"10_CR60","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.surg.2021.07.035","volume":"171","author":"A Machens","year":"2022","unstructured":"Machens A, Kaatzsch P, Lorenz K, Horn LC, Wickenhauser C, Schmid KW, Dralle H, Siebolts U (2022a) Abandoning node dissection for desmoplasia-negative encapsulated unifocal sporadic medullary thyroid cancer. Surgery 171:360\u2013367","journal-title":"Surgery"},{"key":"10_CR61","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1002\/hed.27181","volume":"44","author":"A Machens","year":"2022","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2022b) Superiority of metastatic lymph node ratio over number of node metastases and TNM\/AJCC N classification in predicting cancer-specific survival in medullary thyroid cancer. Head Neck 44:2717\u20132726","journal-title":"Head Neck"},{"key":"10_CR62","doi-asserted-by":"publisher","first-page":"e734","DOI":"10.1210\/clinem\/dgad156","volume":"108","author":"A Machens","year":"2023","unstructured":"Machens A, Lorenz K, Brandenburg T, F\u00fchrer-Sakel D, Weber F, Dralle H (2023a) The changing face of multiple endocrine neoplasia 2A: from symptom-based to preventative medicine. J Clin Endocrinol Metab 108:e734\u2013e742","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR63","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s12020-022-03273-8","volume":"80","author":"A Machens","year":"2023","unstructured":"Machens A, Lorenz K, Huessler EM, Stang A, Weber F, Dralle H (2023b) Temporal trends in referrals of RET gene carriers for neck surgery to a tertiary surgical center in the era of international management guidelines. Endocrine 80:100\u2013110","journal-title":"Endocrine"},{"key":"10_CR64","doi-asserted-by":"crossref","unstructured":"Machens A, Bensch C, Wickenhauser C, Dralle H, Lorenz K (2024a) Comparing nodal with primary tumor desmoplasia uncovers metastatic patterns in multiple endocrine neoplasia 2B. Eur J Endocrinol 190:K21\u2013K25","DOI":"10.1093\/ejendo\/lvad177"},{"key":"10_CR65","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Bensch C, Wickenhauser C, Dralle H (2024b) Tumor desmoplasia outperforms preoperative serum calcitonin as surgical biomarker in sporadic medullary thyroid cancer. Head Neck 46(11):2843\u20132852","DOI":"10.1002\/hed.27827"},{"key":"10_CR66","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Brandenburg T, F\u00fchrer D, Weber F, Dralle H (2024c) Latest progress in risk-adapted surgery for medullary thyroid cancer. Cancers (Basel) 16(5):917","DOI":"10.3390\/cancers16050917"},{"key":"10_CR67","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Weber F, Brandenburg T, F\u00fchrer-Sakel D, Dralle H (2024d) Genotype-specific development of MEN 2 constituent components in 683 RET carriers. Endocr Relat Cancer 31(7):e240038","DOI":"10.1530\/ERC-24-0038"},{"key":"10_CR1001","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2024e) Sexual dimorphism in medullary thyroid cancer aggressiveness. Endocr Relat Cancer 31:e230301","DOI":"10.1530\/ERC-23-0301"},{"key":"10_CR1002","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2024f) Axillary node metastases of medullary thyroid cancer: a hallmark of terminal disease. Horm Metab Res 56(6):429\u2013434","DOI":"10.1055\/a-2172-9263"},{"key":"10_CR1003","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2024g) Anatomical patterns of nodal spread in unilateral papillary and medullary thyroid cancer. Thyroid 34(7):871\u2013879","DOI":"10.1089\/thy.2024.0076"},{"key":"10_CR1004","doi-asserted-by":"crossref","unstructured":"Machens A, Lorenz K, Weber F, Dralle H (2024h) Origin and impact of multifocal growth in sporadic vs. hereditary medullary thyroid cancer. Eur J Surg Oncol 50(11):108625","DOI":"10.1016\/j.ejso.2024.108625"},{"key":"10_CR68","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1056\/NEJM196301102680202","volume":"268","author":"PC Manning","year":"1963","unstructured":"Manning PC, Molnar GD, Black BM, Priestley JT, Woolner LB (1963) Pheochromocytoma, hyperparathyroidism and thyroid carcinoma occurring coincidentally\u2014report of a case. N Engl J Med 268:68\u201372","journal-title":"N Engl J Med"},{"key":"10_CR69","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00268-002-6665-1","volume":"26","author":"A Miyauchi","year":"2002","unstructured":"Miyauchi A, Matsuzuka F, Hirai K, Yokozawa T, Kobayashi K, Ito Y, Nakano K, Kuma K, Futami H, Yamaguchi K (2002) Prospective trial of unilateral surgery for nonhereditary medullary thyroid carcinoma in patients without germline RET mutations. World J Surg 26:1023\u20131028","journal-title":"World J Surg"},{"key":"10_CR70","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1097\/00000658-199906000-00016","volume":"229","author":"JF Moley","year":"1999","unstructured":"Moley JF, DeBenedetti MK (1999) Patterns of nodal metastases in palpable medullary thyroid carcinoma: recommendations for extent of node dissection. Ann Surg 229:880\u2013887","journal-title":"Ann Surg"},{"key":"10_CR71","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1245\/s10434-012-2589-7","volume":"20","author":"LF Morris","year":"2013","unstructured":"Morris LF, Waguespack SG, Edeiken-Monroe BS, Lee JE, Rich TA, Ying AK, Warneke CL, Evans DB, Perrier ND, Grubbs EG (2013) Ultrasonography should not guide the timing of thyroidectomy in pediatric patients diagnosed with multiple endocrine neoplasia syndrome 2A through genetic screening. Ann Surg Oncol 20:53\u201359","journal-title":"Ann Surg Oncol"},{"key":"10_CR72","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/363458a0","volume":"363","author":"LM Mulligan","year":"1993","unstructured":"Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius HK, Tunnacliffe A, Ponder BA (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458\u2013460","journal-title":"Nature"},{"key":"10_CR73","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/thy.2019.0785","volume":"30","author":"MB Niederle","year":"2020","unstructured":"Niederle MB, Scheuba C, Riss P, Selberherr A, Koperek O, Niederle B (2020) Early diagnosis of medullary thyroid cancer: are calcitonin stimulation tests still indicated in the era of highly sensitive calcitonin immunoassays? Thyroid 30:974\u2013984","journal-title":"Thyroid"},{"key":"10_CR74","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/BF00284951","volume":"27","author":"AGE Pearse","year":"1971","unstructured":"Pearse AGE, Polak JM (1971) Cytochemical evidence for the neural crest origin of mammalian ultimobranchial C-cells. Histochemistry 27:96\u2013102","journal-title":"Histochemistry"},{"key":"10_CR75","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/bjs.10856","volume":"105","author":"FP Prete","year":"2018","unstructured":"Prete FP, Abdel-Aziz T, Morkane C, Brain C, Kurzawinski TR, MEN2 in Children UK Collaborative Group (2018) Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2. Br J Surg 105:1319\u20131327","journal-title":"Br J Surg"},{"key":"10_CR76","doi-asserted-by":"publisher","first-page":"e613","DOI":"10.1210\/clinem\/dgad061","volume":"108","author":"A Prete","year":"2023","unstructured":"Prete A, Gambale C, Torregrossa L, Ciampi R, Romei C, Ramone T, Agate L, Bottici V, Cappagli V, Molinaro E, Materazzi G, Elisei R, Matrone A (2023) Clinical evolution of sporadic medullary thyroid carcinoma with biochemical incomplete response after initial treatment. J Clin Endocrinol Metab 108:e613\u2013e622","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR77","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.surg.2016.04.053","volume":"161","author":"RW Randle","year":"2017","unstructured":"Randle RW, Balentine CJ, Leverson GE, Havlena JA, Sippel RS, Schneider DF, Pitt SC (2017) Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years. Surgery 161:137\u2013146","journal-title":"Surgery"},{"key":"10_CR78","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1210\/jc.2017-01884","volume":"103","author":"F Raue","year":"2018","unstructured":"Raue F, Dralle H, Machens A, Bruckner T, Frank-Raue K (2018) Long-term survivorship in multiple endocrine neoplasia type 2B diagnosed before and in the new millennium. J Clin Endocrinol Metab 103:235\u2013243","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR79","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1210\/jc.2019-00516","volume":"104","author":"F Raue","year":"2019","unstructured":"Raue F, Bruckner T, Frank-Raue K (2019) Long-term outcomes and aggressiveness of hereditary medullary thyroid carcinoma: 40 years of experience at one center. J Clin Endocrinol Metab 104:4264\u20134272","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR80","doi-asserted-by":"publisher","first-page":"e3582","DOI":"10.1210\/clinem\/dgab326","volume":"106","author":"F Raue","year":"2021","unstructured":"Raue F, Bruckner T, Frank-Raue K (2021) Similar stage-dependent survival and outcome in sporadic and hereditary medullary thyroid carcinoma. J Clin Endocrinol Metab 106:e3582\u2013e3591","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR81","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/bjs.10792","volume":"105","author":"R Schneider","year":"2018","unstructured":"Schneider R, Machens A, Sekulla C, Lorenz K, Weber F, Dralle H (2018) Twenty-year experience of paediatric thyroid surgery using intraoperative nerve monitoring. Br J Surg 105:996\u20131005","journal-title":"Br J Surg"},{"key":"10_CR82","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/bjs.11901","volume":"108","author":"R Schneider","year":"2021","unstructured":"Schneider R, Machens A, Sekulla C, Lorenz K, Elwerr M, Dralle H (2021) Superiority of continuous over intermittent intraoperative nerve monitoring in preventing vocal cord palsy. Br J Surg 108:566\u2013573","journal-title":"Br J Surg"},{"key":"10_CR83","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1210\/jc.2002-021713","volume":"88","author":"C Scollo","year":"2003","unstructured":"Scollo C, Baudin E, Travagli JP, Caillou B, Bellon N, Leboulleux S, Schlumberger M (2003) Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer. J Clin Endocrinol Metab 88:2070\u20132075","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR84","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0002-9343(61)90234-0","volume":"31","author":"JH Sipple","year":"1961","unstructured":"Sipple JH (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31:163\u2013166","journal-title":"Am J Med"},{"key":"10_CR85","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1056\/NEJMoa043999","volume":"353","author":"MA Skinner","year":"2005","unstructured":"Skinner MA, Moley JA, Dilley WG, Owzar K, DeBenedetti MK, Wells SA (2005) Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med 353:1105\u20131113","journal-title":"N Engl J Med"},{"key":"10_CR86","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF01995500","volume":"201","author":"E Stoffel","year":"1910","unstructured":"Stoffel E (1910) Lokales Amyloid der Schilddr\u00fcse. Virchows Arch 201:245\u2013252","journal-title":"Virchows Arch"},{"key":"10_CR87","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1056\/NEJM196808082790602","volume":"279","author":"AH Tashjian Jr","year":"1968","unstructured":"Tashjian AH Jr, Melvin EW (1968) Medullary carcinoma of the thyroid gland. Studies of thyrocalcitonin in plasma and tumor extracts. N Engl J Med 279:279\u2013283","journal-title":"N Engl J Med"},{"key":"10_CR88","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1056\/NEJM197010222831702","volume":"283","author":"AH Tashjian Jr","year":"1970","unstructured":"Tashjian AH Jr, Howland BG, Melvin KEW, Hill CS Jr (1970) Immunoassay of human calcitonin: clinical measurement, relation to serum calcium and studies in patients with medullary thyroid carcinoma. N Engl J Med 283:890\u2013895","journal-title":"N Engl J Med"},{"key":"10_CR89","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1530\/EJE-21-1015","volume":"186","author":"T Weber","year":"2022","unstructured":"Weber T, Poplawski A, Vorl\u00e4nder C, Dotzenrath C, Ringelband R, Schabram J, Passler C, Zielke A, Schlegel N, Nies C, Krenz D, J\u00e4hne J, Schwab R, Bartsch DK, Binneb\u00f6sel M, Kemen M, Klinger C, Buhr H, Lorenz K (2022) Preoperative calcitonin testing improves the diagnosis of medullary thyroid carcinoma in female and male patients. Eur J Endocrinol 186:223\u2013231","journal-title":"Eur J Endocrinol"},{"key":"10_CR90","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","volume":"25","author":"SA Wells Jr","year":"2015","unstructured":"Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG, American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma (2015) Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid 25:567\u2013610","journal-title":"Thyroid"},{"key":"10_CR91","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/00000658-199409000-00002","volume":"200","author":"SA Wells","year":"1994","unstructured":"Wells SA, Chi DD, Toshima K, Dehner LP, Coffin CM, Dowton B, Ivanovich JL, DeBenedetti MK, Dilley WG, Moley JF, Norton JA, Donis-Keller H (1994) Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A. Ann Surg 200:237\u2013250","journal-title":"Ann Surg"},{"key":"10_CR92","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1136\/jcp.18.3.288","volume":"18","author":"ED Williams","year":"1965","unstructured":"Williams ED (1965) A review of 17 cases of carcinoma of the thyroid and phaeochromocytoma. J Clin Path 18:288\u2013292","journal-title":"J Clin Path"},{"key":"10_CR93","first-page":"1","volume":"29","author":"A W\u00f6lfer","year":"1883","unstructured":"W\u00f6lfer A (1883) \u00dcber die Entwicklung und den Bau des Kropfes. Arch Klin Chir 29:1\u201397 and 754\u2013866","journal-title":"Arch Klin Chir"},{"key":"10_CR94","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/thy.2023.0279","volume":"34","author":"B Xu","year":"2024","unstructured":"Xu B, Viswanathan K, Ahadi MS, Ahmadi S, Alzumaili B, Bani MA, Baudin E, Behrman DB, Capelletti M, Chau NG, Chiarucci F, Chou A, Clifton-Bligh R, Coluccelli S, de Biase D, De Leo A, Dogan S, Fagin JA, Fuchs TL, Glover AR, Hadoux J, Lacroix L, Lamartina L, Lubin DJ, Luxford C, Magliocca K, Maloberti T, Mohanty AS, Najdawi F, Nigam A, Papachristos AJ, Repaci A, Robinson B, Scoazec JY, Shi Q, Sidhu S, Solaroli E, Sywak M, Tuttle RM, Untch B, Barletta JA, Al Ghuzlan A, Gill AJ, Ghossein R, Tallini G, Ganly I (2024) Association of the genomic profile of medullary thyroid carcinoma with tumor characteristics and clinical outcomes in an international multicenter study. Thyroid 34:167\u2013176","journal-title":"Thyroid"},{"key":"10_CR95","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1089\/thy.2019.0579","volume":"30","author":"T Yeh","year":"2020","unstructured":"Yeh T, Yeung M, Sherman EJ, Tuttle RM, Sabra MM (2020) Structural doubling time predicts overall survival in patients with medullary thyroid cancer in patients with rapidly progressive metastatic medullary thyroid cancer treated with molecular targeted therapies. Thyroid 30:1112\u20131119","journal-title":"Thyroid"}],"container-title":["Recent Results in Cancer Research","Medullary Thyroid Carcinoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-80396-3_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:32:13Z","timestamp":1742358733000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-80396-3_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031803956","9783031803963"],"references-count":96,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-80396-3_10","relation":{},"ISSN":["0080-0015","2197-6767"],"issn-type":[{"value":"0080-0015","type":"print"},{"value":"2197-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"20 March 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}