{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T16:27:20Z","timestamp":1749659240081,"version":"3.40.4"},"publisher-location":"Cham","reference-count":81,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031829895","type":"print"},{"value":"9783031829901","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-82990-1_15","type":"book-chapter","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T15:49:02Z","timestamp":1745941742000},"page":"355-374","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interacting Fat1 and Dchs Planar Cell Polarity Proteins Supported by Fjx1 Serve as Heterodimeric Intercellular Bridges Crucial to Support Spermatogenesis"],"prefix":"10.1007","author":[{"given":"Tiao","family":"Bu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damin","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Yan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"15_CR1","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s00439-014-1456-y","volume":"133","author":"M Alders","year":"2014","unstructured":"Alders, M., Al-Gazali, L., Cordeiro, I., Dallapiccola, B., Garavelli, L., Tuysuz, B., Salehi, F., Haagmans, M.A., Mook, O.R., Majoie, C.B., Mannens, M.M., Hennekam, R.C.: Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome. Hum. Genet. 133, 1161\u20131167 (2014)","journal-title":"Hum. Genet."},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12253-014-9804-8","volume":"21","author":"CH An","year":"2014","unstructured":"An, C.H., Je, E.M., Yoo, N.J., Lee, S.H.: Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. Pathol. Oncol. Res. 21, 181\u2013185 (2014)","journal-title":"Pathol. Oncol. Res."},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ceb.2016.08.002","volume":"44","author":"WY Aw","year":"2017","unstructured":"Aw, W.Y., Devenport, D.: Planar cell polarity: global inputs establishing cellular asymmetry. Curr. Opin. Cell Biol. 44, 110\u2013116 (2017)","journal-title":"Curr. Opin. Cell Biol."},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.celrep.2014.06.009","volume":"8","author":"T Ayukawa","year":"2014","unstructured":"Ayukawa, T., Akiyama, M., Mummery-Widmer, J.L., Stoeger, T., Sasaki, J., Knoblich, J.A., Senoo, H., Sasaki, T., Yamazaki, M.: Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in drosophila. Cell Rep. 8, 610\u2013621 (2014)","journal-title":"Cell Rep."},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nm.2063","volume":"16","author":"JL Barlow","year":"2009","unstructured":"Barlow, J.L., Drynan, L.F., Hewett, D.R., Holmes, L.R., Lorenzo-Abalde, S., Lane, A.L., Jolin, H.E., Pannell, R., Middleton, A.J., Wong, S.H., Warren, A.J., Wainscoat, J.S., Boultwood, J., McKenzie, A.N.J.: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q\u2013 syndrome. Nat. Med. 16, 59\u201366 (2009)","journal-title":"Nat. Med."},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1007\/s00429-015-1051-6","volume":"221","author":"C Beste","year":"2016","unstructured":"Beste, C., Ocklenburg, S., von der Hagen, M., Di Donato, N.: Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture. Brain Struct. Funct. 221, 2487\u20132491 (2016)","journal-title":"Brain Struct. Funct."},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1172\/JCI99027","volume":"130","author":"KL Betterman","year":"2020","unstructured":"Betterman, K.L., Sutton, D.L., Secker, G.A., Kazenwadel, J., Oszmiana, A., Lim, L., Miura, N., Sorokin, L., Hogan, B.M., Kahn, M.L., McNeill, H., Harvey, N.L.: Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. J. Clin. Invest. 130, 3315\u20133328 (2020)","journal-title":"J. Clin. Invest."},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ceb.2017.11.006","volume":"51","author":"S Blair","year":"2018","unstructured":"Blair, S., McNeill, H.: Big roles for fat cadherins. Curr. Opin. Cell Biol. 51, 73\u201380 (2018)","journal-title":"Curr. Opin. Cell Biol."},{"key":"15_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.111936","volume":"571","author":"T Bu","year":"2023","unstructured":"Bu, T., Li, X., Wang, L., Wu, X., Gao, S., Yun, D., Li, L., Sun, F., Cheng, C.Y.: Regulation of Sertoli cell function by planar cell polarity (PCP) protein Fjx1. Mol. Cell. Endocrinol. 571, 111936 (2023)","journal-title":"Mol. Cell. Endocrinol."},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"bqae041","DOI":"10.1210\/endocr\/bqae041","volume":"165","author":"T Bu","year":"2024","unstructured":"Bu, T., Wang, L., Wu, X., Gao, S., Li, X., Yun, D., Yang, X., Li, L., Cheng, C.Y., Sun, F.: The planar cell polarity protein Fat1 in Sertoli cell function. Endocrinology. 165, bqae041 (2024). https:\/\/doi.org\/10.1210\/endocr\/bqae041","journal-title":"Endocrinology"},{"key":"15_CR11","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/ng.2765","volume":"45","author":"S Cappello","year":"2013","unstructured":"Cappello, S., Gray, M.J., Badouel, C., Lange, S., Einsiedler, M., Srour, M., Chitayat, D., Hamdan, F.F., Jenkins, Z.A., Morgan, T., Preitner, N., Uster, T., Thomas, J., Shannon, P., Morrison, V., Di Donato, N., Van Maldergem, L., Neuhann, T., Newbury-Ecob, R., Swinkells, M., Terhal, P., Wilson, L.C., Zwijnenburg, P.J., Sutherland-Smith, A.J., Black, M.A., Markie, D., Michaud, J.L., Simpson, M.A., Mansour, S., McNeill, H., Gotz, M., Robertson, S.P.: Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nat. Genet. 45, 1300\u20131308 (2013)","journal-title":"Nat. Genet."},{"key":"15_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003550","volume":"9","author":"N Caruso","year":"2013","unstructured":"Caruso, N., Herberth, B., Bartoli, M., Puppo, F., Dumonceaux, J., Zimmermann, A., Denadai, S., Lebosse, M., Roche, S., Geng, L., Magdinier, F., Attarian, S., Bernard, R., Maina, F., Levy, N., Helmbacher, F.: Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. PLoS Genet. 9, e1003550 (2013)","journal-title":"PLoS Genet."},{"key":"15_CR13","doi-asserted-by":"publisher","first-page":"3857853","DOI":"10.1155\/2019\/3857853","volume":"2019","author":"SJ Chai","year":"2019","unstructured":"Chai, S.J., Ahmad Zabidi, M.M., Gan, S.P., Rajadurai, P., Lim, P.V.H., Ng, C.C., Yap, L.F., Teo, S.H., Lim, K.P., Patel, V., Cheong, S.C.: An oncogenic role for four-jointed box 1 (FJX1) in nasopharyngeal carcinoma. Dis. Markers. 2019, 3857853 (2019)","journal-title":"Dis. Markers"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/1933719117716780","volume":"25","author":"HJ Chang","year":"2018","unstructured":"Chang, H.J., Yoo, J.Y., Kim, T.H., Fazleabas, A.T., Young, S.L., Lessey, B.A., Jeong, J.W.: Overexpression of four joint Box-1 protein (FJX1) in eutopic endometrium from women with endometriosis. Reprod. Sci. 25, 207\u2013213 (2018)","journal-title":"Reprod. Sci."},{"key":"15_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.semcdb.2016.04.010","volume":"59","author":"H Chen","year":"2016","unstructured":"Chen, H., Cheng, C.Y.: Planar cell polarity (PCP) proteins and spermatogenesis. Semin. Cell Dev. Biol. 59, 99\u2013109 (2016)","journal-title":"Semin. Cell Dev. Biol."},{"key":"15_CR16","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1210\/en.2015-1987","volume":"157","author":"H Chen","year":"2016","unstructured":"Chen, H., Mruk, D.D., Lee, W.M., Cheng, C.Y.: Planar cell polarity (PCP) protein Vangl2 regulates ectoplasmic specialization dynamics via its effects on actin microfilaments in the testes of male rats. Endocrinology. 157, 2140\u20132159 (2016)","journal-title":"Endocrinology"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.semcdb.2017.09.008","volume":"81","author":"H Chen","year":"2018","unstructured":"Chen, H., Mruk, D.D., Lui, W.Y., Wong, C.K.C., Lee, W.M., Cheng, C.Y.: Cell polarity and planar cell polarity (PCP) in spermatogenesis. Semin. Cell Dev. Biol. 81, 71\u201377 (2018)","journal-title":"Semin. Cell Dev. Biol."},{"key":"15_CR18","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41419-018-0339-x","volume":"9","author":"H Chen","year":"2018","unstructured":"Chen, H., Xiao, X., Lui, W.Y., Lee, W.M., Cheng, C.Y.: Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis. Cell Death Dis. 9, 340 (2018)","journal-title":"Cell Death Dis."},{"key":"15_CR19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.devcel.2013.07.006","volume":"26","author":"M-L Chin","year":"2013","unstructured":"Chin, M.-L., Mlodzik, M.: The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization. Dev. Cell. 26, 455\u2013468 (2013)","journal-title":"Dev. Cell"},{"key":"15_CR20","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1128\/MCB.23.10.3575-3582.2003","volume":"23","author":"L Ciani","year":"2003","unstructured":"Ciani, L., Patel, A., Allen, N.D., ffrench-Constant C.: Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype. Mol. Cell. Biol. 23, 3575\u20133582 (2003)","journal-title":"Mol. Cell. Biol."},{"key":"15_CR21","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/s41591-018-0177-5","volume":"24","author":"N Coudray","year":"2018","unstructured":"Coudray, N., Ocampo, P.S., Sakellaropoulos, T., Narula, N., Snuderl, M., Fenyo, D., Moreira, A.L., Razavian, N., Tsirigos, A.: Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nat. Med. 24, 1559\u20131567 (2018)","journal-title":"Nat. Med."},{"key":"15_CR22","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.neuron.2011.06.026","volume":"71","author":"MR Deans","year":"2011","unstructured":"Deans, M.R., Krol, A., Abraira, V.E., Copley, C.O., Tucker, A.F., Goodrich, L.V.: Control of neuronal morphology by the atypical cadherin Fat3. Neuron. 71, 820\u2013832 (2011)","journal-title":"Neuron"},{"key":"15_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.887100","volume":"10","author":"CA Dreyer","year":"2022","unstructured":"Dreyer, C.A., VanderVorst, K., Carraway 3rd., K.L.: Vangl as a master scaffold for Wnt\/planar cell polarity signaling in development and disease. Front. Cell Dev. Biol. 10, 887100 (2022)","journal-title":"Front. Cell Dev. Biol."},{"key":"15_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature14670","volume":"525","author":"R Durst","year":"2015","unstructured":"Durst, R., Sauls, K., Peal, D.S., deVlaming, A., Toomer, K., Leyne, M., Salani, M., Talkowski, M.E., Brand, H., Perrocheau, M., Simpson, C., Jett, C., Stone, M.R., Charles, F., Chiang, C., Lynch, S.N., Bouatia-Naji, N., Delling, F.N., Freed, L.A., Tribouilloy, C., Le Tourneau, T., LeMarec, H., Fernandez-Friera, L., Solis, J., Trujillano, D., Ossowski, S., Estivill, X., Dina, C., Bruneval, P., Chester, A., Schott, J.J., Irvine, K.D., Mao, Y., Wessels, A., Motiwala, T., Puceat, M., Tsukasaki, Y., Menick, D.R., Kasiganesan, H., Nie, X., Broome, A.M., Williams, K., Johnson, A., Markwald, R.R., Jeunemaitre, X., Hagege, A., Levine, R.A., Milan, D.J., Norris, R.A., Slaugenhaupt, S.A.: Mutations in DCHS1 cause mitral valve prolapse. Nature. 525, 109\u2013113 (2015)","journal-title":"Nature"},{"key":"15_CR25","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/path.5286","volume":"249","author":"C Formica","year":"2019","unstructured":"Formica, C., Happ\u00e9, H., Veraar, K.A., Vortkamp, A., Scharpfenecker, M., McNeill, H., Peters, D.J.: Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury. J. Pathol. 249, 114\u2013125 (2019)","journal-title":"J. Pathol."},{"key":"15_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ceb.2019.10.006","volume":"62","author":"AD Fulford","year":"2020","unstructured":"Fulford, A.D., McNeill, H.: Fat\/Dachsous family cadherins in cell and tissue organisation. Curr. Opin. Cell Biol. 62, 96\u2013103 (2020)","journal-title":"Curr. Opin. Cell Biol."},{"key":"15_CR27","doi-asserted-by":"publisher","first-page":"28589","DOI":"10.1038\/srep28589","volume":"6","author":"Y Gao","year":"2016","unstructured":"Gao, Y., Lui, W.Y., Lee, W.M., Cheng, C.Y.: Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Sci. Rep. 6, 28589 (2016)","journal-title":"Sci. Rep."},{"key":"15_CR28","doi-asserted-by":"publisher","first-page":"10822","DOI":"10.1038\/ncomms10822","volume":"7","author":"HY Gee","year":"2016","unstructured":"Gee, H.Y., Sadowski, C.E., Aggarwal, P.K., Porath, J.D., Yakulov, T.A., Schueler, M., Lovric, S., Ashraf, S., Braun, D.A., Halbritter, J., Fang, H., Airik, R., Vega-Warner, V., Cho, K.J., Chan, T.A., Morris, L.G., Allen, N., McNeill, H., Buscher, R., Kyrieleis, H., Wallot, M., Gaspert, A., Kistler, T., Milford, D.V., Saleem, M.A., Keng, W.T., Alexander, S.I., Valentini, R.P., Licht, C., Teh, J.C., Bogdanovic, R., Koziell, A., Bierzynska, A., Soliman, N.A., Otto, E.A., Lifton, R.P., Holzman, L.B., Sibinga, N.E., Walz, G., Tufro, A., Hildebrandt, F.: FAT1 mutations cause a glomerulotubular nephropathy. Nat. Commun. 7, 10822 (2016)","journal-title":"Nat. Commun."},{"key":"15_CR29","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.semcdb.2017.07.014","volume":"69","author":"AM Goffinet","year":"2017","unstructured":"Goffinet, A.M., Tissir, F.: Seven pass Cadherins CELSR1-3. Semin. Cell Dev. Biol. 69, 102\u2013110 (2017)","journal-title":"Semin. Cell Dev. Biol."},{"key":"15_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.842593","volume":"10","author":"A Gridnev","year":"2022","unstructured":"Gridnev, A., Misra, J.R.: Emerging mechanisms of growth and patterning regulation by Dachsous and fat Protocadherins. Front. Cell Dev. Biol. 10, 842593 (2022)","journal-title":"Front. Cell Dev. Biol."},{"key":"15_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.603660","volume":"11","author":"Z Guo","year":"2021","unstructured":"Guo, Z., Yan, X., Song, C., Wang, Q., Wang, Y., Liu, X.P., Huang, J., Li, S., Hu, W.: FAT3 mutation is associated with tumor mutation burden and poor prognosis in esophageal cancer. Front. Oncol. 11, 603660 (2021)","journal-title":"Front. Oncol."},{"key":"15_CR32","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1042\/BST20190404","volume":"48","author":"C Harrison","year":"2020","unstructured":"Harrison, C., Shao, H., Strutt, H., Strutt, D.: Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins. Biochem. Soc. Trans. 48, 1297\u20131308 (2020)","journal-title":"Biochem. Soc. Trans."},{"key":"15_CR33","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/14647273.2018.1534277","volume":"23","author":"M Heidari","year":"2020","unstructured":"Heidari, M., Darbani, S., Darbandi, M., Lakpour, N., Fathi, Z., Zarnani, A.H., Zeraati, H., Akhondi, M.M., Sadeghi, M.R.: Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection. Hum. Fertil. (Camb.). 23, 123\u2013133 (2020)","journal-title":"Hum. Fertil. (Camb.)"},{"key":"15_CR34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/jemt.20783","volume":"73","author":"L Hermo","year":"2010","unstructured":"Hermo, L., Pelletier, R.M., Cyr, D.G., Smith, C.E.: Surfing the wave, cycle, life history, and genes\/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes. Microsc. Res. Tech. 73, 241\u2013278 (2010)","journal-title":"Microsc. Res. Tech."},{"key":"15_CR35","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/jemt.20787","volume":"73","author":"L Hermo","year":"2010","unstructured":"Hermo, L., Pelletier, R.M., Cyr, D.G., Smith, C.E.: Surfing the wave, cycle, life history, and genes\/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa. Microsc. Res. Tech. 73, 279\u2013319 (2010)","journal-title":"Microsc. Res. Tech."},{"key":"15_CR36","first-page":"1","volume":"636","author":"RA Hess","year":"2008","unstructured":"Hess, R.A., de Franca, L.R.: Spermatogenesis and cycle of the seminiferous epithelium. Adv. Exp. Med. Biol. 636, 1\u201315 (2008)","journal-title":"Adv. Exp. Med. Biol."},{"key":"15_CR37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.ctdb.2016.11.003","volume":"123","author":"Y Keira","year":"2017","unstructured":"Keira, Y., Wada, M., Ishikawa, H.O.: Regulation of drosophila development by the Golgi kinase four-jointed. Curr. Top. Dev. Biol. 123, 143\u2013179 (2017)","journal-title":"Curr. Top. Dev. Biol."},{"key":"15_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/bs.ctdb.2022.03.006","volume":"150","author":"Y Koca","year":"2022","unstructured":"Koca, Y., Collu, G.M., Mlodzik, M.: Wnt-frizzled planar cell polarity signaling in the regulation of cell motility. Curr. Top. Dev. Biol. 150, 255\u2013297 (2022)","journal-title":"Curr. Top. Dev. Biol."},{"key":"15_CR39","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1242\/dev.131037","volume":"143","author":"A Kuta","year":"2016","unstructured":"Kuta, A., Mao, Y., Martin, T., Ferreira de Sousa, C., Whiting, D., Zakaria, S., Crespo-Enriquez, I., Evans, P., Balczerski, B., Mankoo, B., Irvine, K.D., Francis-West, P.H.: Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 143, 2367\u20132375 (2016)","journal-title":"Development"},{"key":"15_CR40","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ydbio.2013.09.007","volume":"383","author":"KT Lawlor","year":"2013","unstructured":"Lawlor, K.T., Ly, D.C., DiNardo, S.: Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field. Dev. Biol. 383, 285\u2013294 (2013)","journal-title":"Dev. Biol."},{"key":"15_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2013.01.030","volume":"377","author":"PA Lawrence","year":"2013","unstructured":"Lawrence, P.A., Casal, J.: The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns. Dev. Biol. 377, 1\u20138 (2013)","journal-title":"Dev. Biol."},{"key":"15_CR42","doi-asserted-by":"crossref","unstructured":"Lawrence, P.A., Casal, J.: Planar cell polarity: two genetic systems use one mechanism to read gradients. Development. 145 (2018)","DOI":"10.1242\/dev.168229"},{"key":"15_CR43","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1136\/heartjnl-2017-312420","volume":"104","author":"T Le Tourneau","year":"2018","unstructured":"Le Tourneau, T., M\u00e9rot, J., Rimbert, A., Le Scouarnec, S., Probst, V., Le Marec, H., Levine, R.A., Schott, J.-J.: Genetics of syndromic and non-syndromic mitral valve prolapse. Heart. 104, 978\u2013984 (2018)","journal-title":"Heart"},{"key":"15_CR44","first-page":"2704","volume":"142","author":"N Li-Villarreal","year":"2015","unstructured":"Li-Villarreal, N., Forbes, M.M., Loza, A.J., Chen, J., Ma, T., Helde, K., Moens, C.B., Shin, J., Sawada, A., Hindes, A.E., Dubrulle, J., Schier, A.F., Longmore, G.D., Marlow, F.L., Solnica-Krezel, L.: Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development. 142, 2704\u20132718 (2015)","journal-title":"Development"},{"key":"15_CR45","doi-asserted-by":"publisher","first-page":"bqac009","DOI":"10.1210\/endocr\/bqac009","volume":"163","author":"L Li","year":"2022","unstructured":"Li, L., Gao, S., Wang, L., Bu, T., Chu, J., Lv, L., Tahir, A., Mao, B., Li, H., Li, X., Wang, Y., Wu, X., Ge, R., Cheng, C.Y.: PCP protein Inversin regulates testis function through changes in cytoskeletal organization of Actin and Microtubules. Endocrinology. 163, bqac009 (2022)","journal-title":"Endocrinology"},{"key":"15_CR46","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41419-019-1394-7","volume":"10","author":"L Li","year":"2019","unstructured":"Li, L., Mao, B., Yan, M., Wu, S., Ge, R., Lian, Q., Cheng, C.Y.: Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization. Cell Death Dis. 10, 194 (2019). https:\/\/doi.org\/10.1038\/s41419-019-1394-7","journal-title":"Cell Death Dis."},{"key":"15_CR47","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/ng.2935","volume":"46","author":"DC Lin","year":"2014","unstructured":"Lin, D.C., Hao, J.J., Nagata, Y., Xu, L., Shang, L., Meng, X., Sato, Y., Okuno, Y., Varela, A.M., Ding, L.W., Garg, M., Liu, L.Z., Yang, H., Yin, D., Shi, Z.Z., Jiang, Y.Y., Gu, W.Y., Gong, T., Zhang, Y., Xu, X., Kalid, O., Shacham, S., Ogawa, S., Wang, M.R., Koeffler, H.P.: Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat. Genet. 46, 467\u2013473 (2014)","journal-title":"Nat. Genet."},{"key":"15_CR48","doi-asserted-by":"crossref","unstructured":"Lodge, E.J., Xekouki, P., Silva, T.S., Kochi, C., Longui, C.A., Faucz, F.R., Santambrogio, A., Mills, J.L., Pankratz, N., Lane, J., Sosnowska, D., Hodgson, T., Patist, A.L., Francis-West, P., Helmbacher, F., Stratakis, C., Andoniadou, C.L.: Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. JCI Insight. 5 (2020)","DOI":"10.1172\/jci.insight.134310"},{"key":"15_CR49","doi-asserted-by":"publisher","first-page":"16473","DOI":"10.1038\/srep16473","volume":"5","author":"B Luzon-Toro","year":"2015","unstructured":"Luzon-Toro, B., Gui, H., Ruiz-Ferrer, M., Sze-Man Tang, C., Fernandez, R.M., Sham, P.C., Torroglosa, A., Kwong-Hang Tam, P., Espino-Paisan, L., Cherny, S.S., Bleda, M., Enguix-Riego Mdel, V., Dopazo, J., Antinolo, G., Garcia-Barcelo, M.M., Borrego, S.: Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease. Sci. Rep. 5, 16473 (2015)","journal-title":"Sci. Rep."},{"key":"15_CR50","doi-asserted-by":"publisher","first-page":"11469","DOI":"10.1038\/ncomms11469","volume":"7","author":"Y Mao","year":"2016","unstructured":"Mao, Y., Kuta, A., Crespo-Enriquez, I., Whiting, D., Martin, T., Mulvaney, J., Irvine, K.D., Francis-West, P.: Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis. Nat. Commun. 7, 11469 (2016)","journal-title":"Nat. Commun."},{"key":"15_CR51","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1242\/dev.057166","volume":"138","author":"Y Mao","year":"2011","unstructured":"Mao, Y., Mulvaney, J., Zakaria, S., Yu, T., Morgan, K.M., Allen, S., Basson, M.A., Francis-West, P., Irvine, K.D.: Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 138, 947\u2013957 (2011)","journal-title":"Development"},{"key":"15_CR52","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1242\/dev.083949","volume":"140","author":"E Marcinkevicius","year":"2013","unstructured":"Marcinkevicius, E., Zallen, J.A.: Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin fat. Development. 140, 433\u2013443 (2013)","journal-title":"Development"},{"key":"15_CR53","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1101\/gad.228098.113","volume":"27","author":"M Matis","year":"2013","unstructured":"Matis, M., Axelrod, J.D.: Regulation of PCP by the Fat signaling pathway. Genes Dev. 27, 2207\u20132220 (2013)","journal-title":"Genes Dev."},{"key":"15_CR54","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02893","volume":"3","author":"M Matis","year":"2014","unstructured":"Matis, M., Russler-Germain, D.A., Hu, Q., Tomlin, C.J., Axelrod, J.D.: Microtubules provide directional information for core PCP function. elife. 3, e02893 (2014)","journal-title":"elife"},{"key":"15_CR55","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/B978-0-12-394592-1.00006-5","volume":"101","author":"H May-Simera","year":"2012","unstructured":"May-Simera, H., Kelley, M.W.: Planar cell polarity in the inner ear. Curr. Top. Dev. Biol. 101, 111\u2013140 (2012)","journal-title":"Curr. Top. Dev. Biol."},{"key":"15_CR56","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/s41467-023-36435-x","volume":"14","author":"E Medina","year":"2023","unstructured":"Medina, E., Easa, Y., Lester, D.K., Lau, E.K., Sprinzak, D., Luca, V.C.: Structure of the planar cell polarity cadherins Fat4 and Dachsous1. Nat. Commun. 14, 891 (2023)","journal-title":"Nat. Commun."},{"key":"15_CR57","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/90074","volume":"28","author":"KJ Mitchell","year":"2001","unstructured":"Mitchell, K.J., Pinson, K.I., Kelly, O.G., Brennan, J., Zupicich, J., Scherz, P., Leighton, P.A., Goodrich, L.V., Lu, X., Avery, B.J., Tate, P., Dill, K., Pangilinan, E., Wakenight, P., Tessier-Lavigne, M., Skarnes, W.C.: Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat. Genet. 28, 241\u2013249 (2001)","journal-title":"Nat. Genet."},{"key":"15_CR58","doi-asserted-by":"publisher","first-page":"a033266","DOI":"10.1101\/cshperspect.a033266","volume":"10","author":"M Montcouquiol","year":"2020","unstructured":"Montcouquiol, M., Kelley, M.W.: Development and patterning of the cochlea: from convergent extension to planar polarity. Cold Spring Harb. Perspect. Med. 10, a033266 (2020). https:\/\/doi.org\/10.1101\/cshperspect.a033266","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"15_CR59","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1095\/biolreprod.113.111682","volume":"89","author":"B Muciaccia","year":"2013","unstructured":"Muciaccia, B., Boitani, C., Berloco, B.P., Nudo, F., Spadetta, G., Stefanini, M., de Rooij, D.G., Vicini, E.: Novel stage classification of human spermatogenesis based on acrosome development. Biol. Reprod. 89, 60 (2013)","journal-title":"Biol. Reprod."},{"key":"15_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.44","volume":"4","author":"M Neumann","year":"2014","unstructured":"Neumann, M., Seehawer, M., Schlee, C., Vosberg, S., Heesch, S., von der Heide, E.K., Graf, A., Krebs, S., Blum, H., Gokbuget, N., Schwartz, S., Hoelzer, D., Greif, P.A., Baldus, C.D.: FAT1 expression and mutations in adult acute lymphoblastic leukemia. Blood Cancer J. 4, e224 (2014)","journal-title":"Blood Cancer J."},{"key":"15_CR61","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1242\/dev.105932","volume":"141","author":"J Olofsson","year":"2014","unstructured":"Olofsson, J., Sharp, K.A., Matis, M., Cho, B., Axelrod, J.D.: Prickle\/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity. Development. 141, 2866\u20132874 (2014)","journal-title":"Development"},{"key":"15_CR62","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41586-020-03046-1","volume":"589","author":"I Pastushenko","year":"2021","unstructured":"Pastushenko, I., Mauri, F., Song, Y., de Cock, F., Meeusen, B., Swedlund, B., Impens, F., Van Haver, D., Opitz, M., Thery, M., Bareche, Y., Lapouge, G., Vermeersch, M., Van Eycke, Y.R., Balsat, C., Decaestecker, C., Sokolow, Y., Hassid, S., Perez-Bustillo, A., Agreda-Moreno, B., Rios-Buceta, L., Jaen, P., Redondo, P., Sieira-Gil, R., Millan-Cayetano, J.F., Sanmatrtin, O., D\u2019Haene, N., Moers, V., Rozzi, M., Blondeau, J., Lemaire, S., Scozzaro, S., Janssens, V., De Troya, M., Dubois, C., P\u00e9rez-Morga, D., Salmon, I., Sotiriou, C., Helmbacher, F., Blanpain, C.: Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature. 589, 448\u2013455 (2021)","journal-title":"Nature"},{"key":"15_CR63","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ydbio.2007.09.054","volume":"312","author":"B Probst","year":"2007","unstructured":"Probst, B., Rock, R., Gessler, M., Vortkamp, A., P\u00fcschel, A.W.: The rodent four-jointed ortholog Fjx1 regulates dendrite extension. Dev. Biol. 312, 461\u2013470 (2007)","journal-title":"Dev. Biol."},{"key":"15_CR64","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/humu.22760","volume":"36","author":"F Puppo","year":"2015","unstructured":"Puppo, F., Dionnet, E., Gaillard, M.C., Gaildrat, P., Castro, C., Vovan, C., Bertaux, K., Bernard, R., Attarian, S., Goto, K., Nishino, I., Hayashi, Y., Magdinier, F., Krahn, M., Helmbacher, F., Bartoli, M., L\u00e9vy, N.: Identification of variants in the 4q35 gene FAT1 in patients with a facioscapulohumeral dystrophy-like phenotype. Hum. Mutat. 36, 443\u2013453 (2015)","journal-title":"Hum. Mutat."},{"key":"15_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.608989","volume":"10","author":"Y Qiu","year":"2020","unstructured":"Qiu, Y., Liu, L., Yang, H., Chen, H., Deng, Q., Xiao, D., Lin, Y., Zhu, C., Li, W., Shao, D., Jiang, W., Wu, K., He, J.: Integrating histologic and genomic characteristics to predict tumor mutation burden of early-stage non-small-cell lung cancer. Front. Oncol. 10, 608989 (2020)","journal-title":"Front. Oncol."},{"key":"15_CR66","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s11010-023-04787-z","volume":"479","author":"KA Radaszkiewicz","year":"2023","unstructured":"Radaszkiewicz, K.A., Sulcova, M., Kohoutkova, E., Harnos, J.: The role of prickle proteins in vertebrate development and pathology. Mol. Cell. Biochem. 479, 1199 (2023)","journal-title":"Mol. Cell. Biochem."},{"key":"15_CR67","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/ng.179","volume":"40","author":"S Saburi","year":"2008","unstructured":"Saburi, S., Hester, I., Fischer, E., Pontoglio, M., Eremina, V., Gessler, M., Quaggin, S.E., Harrison, R., Mount, R., McNeill, H.: Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat. Genet. 40, 1010\u20131015 (2008)","journal-title":"Nat. Genet."},{"key":"15_CR68","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/B978-0-12-394311-8.00010-8","volume":"116","author":"P Sharma","year":"2013","unstructured":"Sharma, P., McNeill, H.: Fat and Dachsous cadherins. Prog. Mol. Biol. Transl. Sci. 116, 215\u2013235 (2013)","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"15_CR69","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jgg.2022.06.007","volume":"50","author":"DL Shi","year":"2023","unstructured":"Shi, D.L.: Planar cell polarity regulators in asymmetric organogenesis during development and disease. J. Genet. Genomics. 50, 63\u201376 (2023)","journal-title":"J. Genet. Genomics"},{"key":"15_CR70","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/s41556-018-0193-1","volume":"20","author":"A Singh","year":"2018","unstructured":"Singh, A., Saha, T., Begemann, I., Ricker, A., N\u00fcsse, H., Thorn-Seshold, O., Klingauf, J., Galic, M., Matis, M.: Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis. Nat. Cell Biol. 20, 1126\u20131133 (2018)","journal-title":"Nat. Cell Biol."},{"key":"15_CR71","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/bs.ctdb.2023.02.010","volume":"154","author":"R Staneva","year":"2023","unstructured":"Staneva, R., Levayer, R.: Cell polarity and extrusion: how to polarize extrusion and extrude misspolarized cells? Curr. Top. Dev. Biol. 154, 131\u2013167 (2023)","journal-title":"Curr. Top. Dev. Biol."},{"key":"15_CR72","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200356","volume":"11","author":"H Strutt","year":"2021","unstructured":"Strutt, H., Strutt, D.: How do the fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? Open Biol. 11, 200356 (2021)","journal-title":"Open Biol."},{"key":"15_CR73","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1210\/en.2012-1670","volume":"153","author":"WH Su","year":"2012","unstructured":"Su, W.H., Wong, E.W.P., Mruk, D.D., Cheng, C.Y.: The scribble\/Lgl\/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis. Endocrinology. 153, 6041\u20136053 (2012)","journal-title":"Endocrinology"},{"key":"15_CR74","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.3892\/ol.2016.5063","volume":"12","author":"G Tate","year":"2016","unstructured":"Tate, G., Kishimoto, K., Mitsuya, T.: A novel mutation of the FAT2 gene in spinal meningioma. Oncol. Lett. 12, 3393\u20133396 (2016)","journal-title":"Oncol. Lett."},{"key":"15_CR75","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/B978-0-12-394311-8.00009-1","volume":"116","author":"F Tissir","year":"2013","unstructured":"Tissir, F., Goffinet, A.M.: Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates. Prog. Mol. Biol. Transl. Sci. 116, 193\u2013214 (2013)","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"15_CR76","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/MCD.0000000000000211","volume":"27","author":"D Ulubas Isik","year":"2018","unstructured":"Ulubas Isik, D., Unal, S., Erol, S., Arslan, Z., Bas, A.Y., Demirel, N.: A newborn diagnosed with van Maldergem syndrome. Clin. Dysmorphol. 27, 63\u201365 (2018)","journal-title":"Clin. Dysmorphol."},{"key":"15_CR77","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.semcdb.2021.04.008","volume":"121","author":"L Wang","year":"2022","unstructured":"Wang, L., Bu, T., Li, L., Wu, X., Wong, C.K.C., Perrotta, A., Silvestrini, B., Sun, F., Cheng, C.Y.: Planar cell polarity (PCP) proteins support spermatogenesis through cytoskeletal organization in the testis. Semin. Cell Dev. Biol. 121, 99\u2013113 (2022)","journal-title":"Semin. Cell Dev. Biol."},{"key":"15_CR78","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1002\/cam4.5119","volume":"12","author":"Z Wang","year":"2023","unstructured":"Wang, Z., Xing, L., Huang, Y., Han, P.: FAT2 mutation is associated with better prognosis and responsiveness to immunotherapy in uterine corpus endometrial carcinoma. Cancer Med. 12, 3797\u20133811 (2023)","journal-title":"Cancer Med."},{"key":"15_CR79","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S1937-6448(09)78007-4","volume":"278","author":"EWP Wong","year":"2009","unstructured":"Wong, E.W.P., Cheng, C.Y.: Polarity proteins and cell-cell interactions in the testis. Int. Rev. Cell Mol. Biol. 278, 309\u2013353 (2009)","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"15_CR80","doi-asserted-by":"publisher","first-page":"9657","DOI":"10.1073\/pnas.0801527105","volume":"105","author":"EWP Wong","year":"2008","unstructured":"Wong, E.W.P., Mruk, D.D., Lee, W.M., Cheng, C.Y.: Par3\/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Proc. Natl. Acad. Sci. USA. 105, 9657\u20139662 (2008)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"15_CR81","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1152\/physiol.00001.2014","volume":"29","author":"X Xiao","year":"2014","unstructured":"Xiao, X., Mruk, D.D., Wong, C.K.C., Cheng, C.Y.: Germ cell transport across the seminiferous epithelium during spermatogenesis. Physiology. 29, 286\u2013298 (2014)","journal-title":"Physiology"}],"container-title":["Advances in Experimental Medicine and Biology","Molecular Male Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-82990-1_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:03:16Z","timestamp":1745946196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-82990-1_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031829895","9783031829901"],"references-count":81,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-82990-1_15","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"30 April 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}