{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:47:10Z","timestamp":1780638430442,"version":"3.54.1"},"publisher-location":"Cham","reference-count":70,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031829895","type":"print"},{"value":"9783031829901","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-82990-1_6","type":"book-chapter","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T15:48:10Z","timestamp":1745941690000},"page":"115-125","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Endocrine Disruptors on Testicular Function"],"prefix":"10.1007","author":[{"given":"Latchoumycandane","family":"Calivarathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premendu Prakash","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"4","key":"6_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1210\/er.2009-0002","volume":"30","author":"E Diamanti-Kandarakis","year":"2009","unstructured":"Diamanti-Kandarakis, E., et al.: Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 30(4), 293\u2013342 (2009)","journal-title":"Endocr. Rev."},{"key":"6_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111215","volume":"527","author":"C Walker","year":"2021","unstructured":"Walker, C., et al.: Impact of endocrine-disrupting chemicals on steroidogenesis and consequences on testicular function. Mol. Cell. Endocrinol. 527, 111215 (2021)","journal-title":"Mol. Cell. Endocrinol."},{"issue":"Suppl 4","key":"6_CR3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1289\/ehp.96104s4741","volume":"104 Suppl 4","author":"J Toppari","year":"1996","unstructured":"Toppari, J., et al.: Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104 Suppl 4(Suppl 4), 741\u2013803 (1996)","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"6_CR4","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1210\/jc.2014-4325","volume":"100","author":"R Hauser","year":"2015","unstructured":"Hauser, R., et al.: Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union. J. Clin. Endocrinol. Metab. 100(4), 1267\u20131277 (2015)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"6_CR5","first-page":"e4834","volume":"106","author":"EV Brauner","year":"2021","unstructured":"Brauner, E.V., et al.: Endocrine disrupting chemicals and risk of testicular cancer: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 106(12), e4834\u2013e4860 (2021)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"6_CR6","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/jemt.20684","volume":"72","author":"K Boekelheide","year":"2009","unstructured":"Boekelheide, K., et al.: Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate. Microsc. Res. Tech. 72(8), 629\u2013638 (2009)","journal-title":"Microsc. Res. Tech."},{"key":"6_CR7","first-page":"315","volume":"101","author":"S Campion","year":"2012","unstructured":"Campion, S., et al.: Male reprotoxicity and endocrine disruption. Exp. Suppl. 101, 315\u2013360 (2012)","journal-title":"Exp. Suppl."},{"issue":"8","key":"6_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3390\/toxics10080425","volume":"10","author":"G Toft","year":"2022","unstructured":"Toft, G., Liew, Z.: Health effects associated with exposures to endocrine disrupting chemicals. Toxics. 10(8), 425 (2022)","journal-title":"Toxics"},{"issue":"1","key":"6_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/humupd\/dmw036","volume":"23","author":"JP Bonde","year":"2016","unstructured":"Bonde, J.P., et al.: The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum. Reprod. Update. 23(1), 104\u2013125 (2016)","journal-title":"Hum. Reprod. Update"},{"key":"6_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.envint.2015.05.012","volume":"83","author":"R Kiyama","year":"2015","unstructured":"Kiyama, R., Wada-Kiyama, Y.: Estrogenic endocrine disruptors: molecular mechanisms of action. Environ. Int. 83, 11\u201340 (2015)","journal-title":"Environ. Int."},{"issue":"4","key":"6_CR11","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/andr.12206","volume":"4","author":"JA McLachlan","year":"2016","unstructured":"McLachlan, J.A.: Environmental signaling: from environmental estrogens to endocrine-disrupting chemicals and beyond. Andrology. 4(4), 684\u2013694 (2016)","journal-title":"Andrology"},{"issue":"4","key":"6_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.33549\/physiolres.931022","volume":"56","author":"D Mullerova","year":"2007","unstructured":"Mullerova, D., Kopecky, J.: White adipose tissue: storage and effector site for environmental pollutants. Physiol. Res. 56(4), 375\u2013382 (2007)","journal-title":"Physiol. Res."},{"issue":"3","key":"6_CR13","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/0002-8703(88)90808-3","volume":"115","author":"A Geibel","year":"1988","unstructured":"Geibel, A., Zehender, M., Brugada, P.: Changes in cycle length at the onset of sustained tachycardias--importance for antitachycardiac pacing. Am. Heart J. 115(3), 588\u2013592 (1988)","journal-title":"Am. Heart J."},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.envint.2017.08.015","volume":"108","author":"DH Lee","year":"2017","unstructured":"Lee, D.H., et al.: A role of low dose chemical mixtures in adipose tissue in carcinogenesis. Environ. Int. 108, 170\u2013175 (2017)","journal-title":"Environ. Int."},{"issue":"9\u201310","key":"6_CR15","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.crvi.2017.07.005","volume":"340","author":"R Barouki","year":"2017","unstructured":"Barouki, R.: Endocrine disruptors: revisiting concepts and dogma in toxicology. C. R. Biol. 340(9\u201310), 410\u2013413 (2017)","journal-title":"C. R. Biol."},{"issue":"8","key":"6_CR16","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1001\/jama.2013.283735","volume":"311","author":"S Ehrlich","year":"2014","unstructured":"Ehrlich, S., et al.: Handling of thermal receipts as a source of exposure to bisphenol A. JAMA. 311(8), 859\u2013860 (2014)","journal-title":"JAMA"},{"issue":"6","key":"6_CR17","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1289\/ehp.95103608","volume":"103","author":"JA Brotons","year":"1995","unstructured":"Brotons, J.A., et al.: Xenoestrogens released from lacquer coatings in food cans. Environ. Health Perspect. 103(6), 608\u2013612 (1995)","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"6_CR18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","volume":"24","author":"LN Vandenberg","year":"2007","unstructured":"Vandenberg, L.N., et al.: Human exposure to bisphenol A (BPA). Reprod. Toxicol. 24(2), 139\u2013177 (2007)","journal-title":"Reprod. Toxicol."},{"issue":"1\u20132","key":"6_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0303-7207(98)00084-7","volume":"142","author":"JC Gould","year":"1998","unstructured":"Gould, J.C., et al.: Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol. Cell. Endocrinol. 142(1\u20132), 203\u2013214 (1998)","journal-title":"Mol. Cell. Endocrinol."},{"issue":"10","key":"6_CR20","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","volume":"139","author":"GG Kuiper","year":"1998","unstructured":"Kuiper, G.G., et al.: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 139(10), 4252\u20134263 (1998)","journal-title":"Endocrinology"},{"issue":"1","key":"6_CR21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.envpol.2010.09.004","volume":"159","author":"S Dong","year":"2011","unstructured":"Dong, S., Terasaka, S., Kiyama, R.: Bisphenol A induces a rapid activation of Erk1\/2 through GPR30 in human breast cancer cells. Environ. Pollut. 159(1), 212\u2013218 (2011)","journal-title":"Environ. Pollut."},{"issue":"4","key":"6_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1289\/ehp.7505","volume":"113","author":"AL Wozniak","year":"2005","unstructured":"Wozniak, A.L., Bulayeva, N.N., Watson, C.S.: Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3\/B6 pituitary tumor cells. Environ. Health Perspect. 113(4), 431\u2013439 (2005)","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"6_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/jb\/mvm158","volume":"142","author":"A Matsushima","year":"2007","unstructured":"Matsushima, A., et al.: Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J. Biochem. 142(4), 517\u2013524 (2007)","journal-title":"J. Biochem."},{"issue":"1","key":"6_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1289\/ehp.10587","volume":"116","author":"H Okada","year":"2008","unstructured":"Okada, H., et al.: Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma. Environ. Health Perspect. 116(1), 32\u201338 (2008)","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"6_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","volume":"24","author":"CA Richter","year":"2007","unstructured":"Richter, C.A., et al.: In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol. 24(2), 199\u2013224 (2007)","journal-title":"Reprod. Toxicol."},{"issue":"1\u20132","key":"6_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0300-483X(02)00597-8","volume":"185","author":"KC Chitra","year":"2003","unstructured":"Chitra, K.C., Latchoumycandane, C., Mathur, P.P.: Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Toxicology. 185(1\u20132), 119\u2013127 (2003)","journal-title":"Toxicology"},{"issue":"3","key":"6_CR27","first-page":"203","volume":"5","author":"KC Chitra","year":"2003","unstructured":"Chitra, K.C., Rao, K.R., Mathur, P.P.: Effect of bisphenol A and co-administration of bisphenol A and vitamin C on epididymis of adult rats: a histological and biochemical study. Asian J. Androl. 5(3), 203\u2013208 (2003)","journal-title":"Asian J. Androl."},{"issue":"3\u20134","key":"6_CR28","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.fct.2011.11.041","volume":"50","author":"SC D'Cruz","year":"2012","unstructured":"D'Cruz, S.C., et al.: Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study. Food Chem. Toxicol. 50(3\u20134), 1124\u20131133 (2012)","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"6_CR29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1933719111415547","volume":"19","author":"SC D'Cruz","year":"2012","unstructured":"D'Cruz, S.C., Jubendradass, R., Mathur, P.P.: Bisphenol A induces oxidative stress and decreases levels of insulin receptor substrate 2 and glucose transporter 8 in rat testis. Reprod. Sci. 19(2), 163\u2013172 (2012)","journal-title":"Reprod. Sci."},{"key":"6_CR30","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/978-1-4939-2285-7_12","volume":"1268","author":"M Jayakanthan","year":"2015","unstructured":"Jayakanthan, M., et al.: A use of homology modeling and molecular docking methods: to explore binding mechanisms of nonylphenol and bisphenol A with antioxidant enzymes. Methods Mol. Biol. 1268, 273\u2013289 (2015)","journal-title":"Methods Mol. Biol."},{"key":"6_CR31","first-page":"57","volume":"228","author":"FP Manfo","year":"2014","unstructured":"Manfo, F.P., et al.: Adverse effects of bisphenol A on male reproductive function. Rev. Environ. Contam. Toxicol. 228, 57\u201382 (2014)","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"2","key":"6_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2203\/dose-response.13-020.Vandenberg","volume":"12","author":"LN Vandenberg","year":"2014","unstructured":"Vandenberg, L.N.: Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study. Dose Response. 12(2), 259\u2013276 (2014)","journal-title":"Dose Response"},{"issue":"8","key":"6_CR33","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1289\/ehp.1307728","volume":"122","author":"J Peretz","year":"2014","unstructured":"Peretz, J., et al.: Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ. Health Perspect. 122(8), 775\u2013786 (2014)","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"6_CR34","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1210\/en.2002-0198","volume":"144","author":"JG Ramos","year":"2003","unstructured":"Ramos, J.G., et al.: Bisphenol a induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology. 144(7), 3206\u20133215 (2003)","journal-title":"Endocrinology"},{"issue":"19","key":"6_CR35","doi-asserted-by":"publisher","first-page":"7014","DOI":"10.1073\/pnas.0502544102","volume":"102","author":"BG Timms","year":"2005","unstructured":"Timms, B.G., et al.: Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc. Natl. Acad. Sci. USA. 102(19), 7014\u20137019 (2005)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"6_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.reprotox.2017.12.002","volume":"76","author":"GD Goncalves","year":"2018","unstructured":"Goncalves, G.D., et al.: Bisphenol A reduces testosterone production in TM3 Leydig cells independently of its effects on cell death and mitochondrial membrane potential. Reprod. Toxicol. 76, 26\u201334 (2018)","journal-title":"Reprod. Toxicol."},{"key":"6_CR37","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.reprotox.2014.10.013","volume":"50","author":"S Qi","year":"2014","unstructured":"Qi, S., et al.: BPA-induced apoptosis of rat Sertoli cells through Fas\/FasL and JNKs\/p38 MAPK pathways. Reprod. Toxicol. 50, 108\u2013116 (2014)","journal-title":"Reprod. Toxicol."},{"key":"6_CR38","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3389\/fendo.2020.00453","volume":"11","author":"F Cariati","year":"2020","unstructured":"Cariati, F., et al.: Bisphenol A-induced epigenetic changes and its effects on the male reproductive system. Front Endocrinol (Lausanne). 11, 453 (2020)","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"6_CR39","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/ijerph15102158","volume":"15","author":"Y Meng","year":"2018","unstructured":"Meng, Y., et al.: Decreased capacity for sperm production induced by perinatal bisphenol A exposure is associated with an increased inflammatory response in the offspring of C57BL\/6 male mice. Int. J. Environ. Res. Public Health. 15(10), 2158 (2018)","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"11","key":"6_CR40","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.biocel.2009.05.016","volume":"41","author":"MW Li","year":"2009","unstructured":"Li, M.W., et al.: Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics? Int. J. Biochem. Cell Biol. 41(11), 2302\u20132314 (2009)","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"6_CR41","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1071\/RD20150","volume":"33","author":"MS Alam","year":"2021","unstructured":"Alam, M.S., Kurohmaru, M.: Di-n-butyl phthalate diminishes testicular steroidogenesis by blocking the hypothalamic-pituitary-testicular axis: relationship with germ cell apoptosis in Japanese quail. Reprod. Fertil. Dev. 33(5), 319\u2013327 (2021)","journal-title":"Reprod. Fertil. Dev."},{"issue":"1","key":"6_CR42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/toxsci\/kfv224","volume":"149","author":"LE Gray Jr","year":"2016","unstructured":"Gray Jr., L.E., et al.: Establishing the \u201cbiological relevance\u201d of dipentyl phthalate reductions in fetal rat testosterone production and plasma and testis testosterone levels. Toxicol. Sci. 149(1), 178\u2013191 (2016)","journal-title":"Toxicol. Sci."},{"key":"6_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envres.2015.06.010","volume":"142","author":"YX Wang","year":"2015","unstructured":"Wang, Y.X., et al.: Phthalate exposure and human semen quality: results from an infertility clinic in China. Environ. Res. 142, 1\u20139 (2015)","journal-title":"Environ. Res."},{"issue":"3","key":"6_CR44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cbi.2011.12.008","volume":"195","author":"K Yuan","year":"2012","unstructured":"Yuan, K., et al.: Effects of phthalates on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities in human and rat testes. Chem. Biol. Interact. 195(3), 180\u2013188 (2012)","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"6_CR45","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.gendis.2018.06.004","volume":"5","author":"WEI Yi","year":"2018","unstructured":"Yi, W.E.I., et al.: DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy. Genes Dis. 5(3), 263\u2013274 (2018)","journal-title":"Genes Dis."},{"key":"6_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112889","volume":"227","author":"Y Hong","year":"2021","unstructured":"Hong, Y., et al.: Exposure to DEHP induces testis toxicity and injury through the ROS\/mTOR\/NLRP3 signaling pathway in immature rats. Ecotoxicol. Environ. Saf. 227, 112889 (2021)","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"6_CR47","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1177\/1091581809355488","volume":"29","author":"S Wu","year":"2010","unstructured":"Wu, S., et al.: Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression. Int. J. Toxicol. 29(2), 193\u2013200 (2010)","journal-title":"Int. J. Toxicol."},{"issue":"11","key":"6_CR48","volume":"16","author":"Chain, E.P.o.C.i.t.F","year":"2018","unstructured":"Chain, E.P.o.C.i.t.F, et al.: Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food. EFSA J. 16(11), e05333 (2018)","journal-title":"EFSA J."},{"issue":"1","key":"6_CR49","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12940-022-00904-5","volume":"21","author":"S Ermler","year":"2022","unstructured":"Ermler, S., Kortenkamp, A.: Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments. Environ. Health. 21(1), 94 (2022)","journal-title":"Environ. Health"},{"key":"6_CR50","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.envint.2016.01.021","volume":"89-90","author":"J Vitku","year":"2016","unstructured":"Vitku, J., et al.: Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic. Environ. Int. 89-90, 166\u2013173 (2016)","journal-title":"Environ. Int."},{"issue":"1","key":"6_CR51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.tiv.2009.08.017","volume":"24","author":"TG Preuss","year":"2010","unstructured":"Preuss, T.G., et al.: Some nonylphenol isomers show antiestrogenic potency in the MVLN cell assay. Toxicol. In Vitro. 24(1), 129\u2013134 (2010)","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"6_CR52","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/toxsci\/kfg150","volume":"75","author":"HJ Lee","year":"2003","unstructured":"Lee, H.J., et al.: Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol. Sci. 75(1), 40\u201346 (2003)","journal-title":"Toxicol. Sci."},{"issue":"11","key":"6_CR53","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1093\/humrep\/dem256","volume":"22","author":"PA Fowler","year":"2007","unstructured":"Fowler, P.A., et al.: Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations. Hum. Reprod. 22(11), 2919\u20132927 (2007)","journal-title":"Hum. Reprod."},{"issue":"4","key":"6_CR54","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2478\/v10001-009-0036-1","volume":"22","author":"J Jurewicz","year":"2009","unstructured":"Jurewicz, J., et al.: Environmental factors and semen quality. Int. J. Occup. Med. Environ. Health. 22(4), 305\u2013329 (2009)","journal-title":"Int. J. Occup. Med. Environ. Health"},{"issue":"8","key":"6_CR55","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1191\/096032701682692946","volume":"20","author":"K Ben Rhouma","year":"2001","unstructured":"Ben Rhouma, K., et al.: Reproductive toxicity of DDT in adult male rats. Hum. Exp. Toxicol. 20(8), 393\u2013397 (2001)","journal-title":"Hum. Exp. Toxicol."},{"issue":"8","key":"6_CR56","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.fct.2009.05.001","volume":"47","author":"FG Uzun","year":"2009","unstructured":"Uzun, F.G., et al.: Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E. Food Chem. Toxicol. 47(8), 1903\u20131908 (2009)","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"6_CR57","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1007\/s00204-002-0388-9","volume":"76","author":"C Latchoumycandane","year":"2002","unstructured":"Latchoumycandane, C., Mathur, P.P.: Induction of oxidative stress in the rat testis after short-term exposure to the organochlorine pesticide methoxychlor. Arch. Toxicol. 76(12), 692\u2013698 (2002)","journal-title":"Arch. Toxicol."},{"issue":"6","key":"6_CR58","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3390\/antiox10060837","volume":"10","author":"S Roychoudhury","year":"2021","unstructured":"Roychoudhury, S., et al.: Environmental factors-induced oxidative stress: hormonal and molecular pathway disruptions in hypogonadism and erectile dysfunction. Antioxidants (Basel). 10(6), 837 (2021)","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"6_CR59","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0890-6238(01)00177-0","volume":"15","author":"KB Delclos","year":"2001","unstructured":"Delclos, K.B., et al.: Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats. Reprod. Toxicol. 15(6), 647\u2013663 (2001)","journal-title":"Reprod. Toxicol."},{"issue":"8","key":"6_CR60","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1289\/ehp.0800158","volume":"117","author":"F Eustache","year":"2009","unstructured":"Eustache, F., et al.: Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility. Environ. Health Perspect. 117(8), 1272\u20131279 (2009)","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"6_CR61","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1093\/humrep\/17.7.1692","volume":"17","author":"RM Sharpe","year":"2002","unstructured":"Sharpe, R.M., et al.: Infant feeding with soy formula milk: effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity. Hum. Reprod. 17(7), 1692\u20131703 (2002)","journal-title":"Hum. Reprod."},{"key":"6_CR62","doi-asserted-by":"crossref","unstructured":"Dobrzynska, M.M., Radzikowska, J.: Genotoxicity and reproductive toxicity of bisphenol A and X-ray\/bisphenol A combination in male mice. Drug Chem Toxicol. 36(1), 19\u201326 (2013)","DOI":"10.3109\/01480545.2011.644561"},{"key":"6_CR63","doi-asserted-by":"crossref","unstructured":"Tiwari, D., Vanage, G.: Mutagenic effect of Bisphenol A on adult rat male germ cells and their fertility. Reprod Toxicol. 40: p. 60\u20138 (2013)","DOI":"10.1016\/j.reprotox.2013.05.013"},{"key":"6_CR64","doi-asserted-by":"crossref","unstructured":"Liu, C., et al.: Exposure to bisphenol A disrupts meiotic progression during spermatogenesis in adult rats through estrogen-like activity. Cell Death Dis. 4, p. e676 (2013)","DOI":"10.1038\/cddis.2013.203"},{"key":"6_CR65","doi-asserted-by":"crossref","unstructured":"Latchoumycandane, C., Chitra, K.C., Mathur, P.P.: 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) induces oxidative stress in the epididymis and epididymal sperm of adult rats. Arch Toxicol. 77(5), 280\u2013284 (2003)","DOI":"10.1007\/s00204-003-0439-x"},{"key":"6_CR66","doi-asserted-by":"crossref","unstructured":"Bjerke, D.L., Peterson, R.E.: Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: different effects of in utero versus lactational exposure. Toxicol. Appl. Pharmacol. 127(2), 241\u2013249 (1994)","DOI":"10.1006\/taap.1994.1158"},{"key":"6_CR67","doi-asserted-by":"crossref","unstructured":"Cederroth, C.R., et al.: Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice. Mol. Cell. Endocrinol. 321(2), 152\u2013160 (2010)","DOI":"10.1016\/j.mce.2010.02.011"},{"key":"6_CR68","doi-asserted-by":"crossref","unstructured":"Meena, R., et al.: Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic development. Food Chem. Toxicol. 99, 70\u201377 (2017)","DOI":"10.1016\/j.fct.2016.11.020"},{"key":"6_CR69","doi-asserted-by":"crossref","unstructured":"Gong, Y., Han, X.D.: Effect of nonylphenol on steroidogenesis of rat Leydig cells. J. Environ. Sci. Health. B. 41(5), 705\u2013715 (2006)","DOI":"10.1080\/03601230600701866"},{"key":"6_CR70","doi-asserted-by":"crossref","unstructured":"Duan, P., et al.: Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways. Reprod. Toxicol. 62, 27\u201338 (2016)","DOI":"10.1016\/j.reprotox.2016.04.016"}],"container-title":["Advances in Experimental Medicine and Biology","Molecular Male Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-82990-1_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:03:52Z","timestamp":1745946232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-82990-1_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031829895","9783031829901"],"references-count":70,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-82990-1_6","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"30 April 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}