{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:40:43Z","timestamp":1792190443724,"version":"4.4.0"},"publisher-location":"Cham","reference-count":242,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031853395","type":"print"},{"value":"9783031853401","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-85340-1_4","type":"book-chapter","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T10:06:18Z","timestamp":1751882778000},"page":"83-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pattern Recognition by NOD-Like Receptors"],"prefix":"10.1007","author":[{"given":"Timo-Daniel","family":"Voss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Hezinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Kufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"issue":"53","key":"4_CR1","doi-asserted-by":"publisher","first-page":"41637","DOI":"10.1074\/jbc.M110.137885","volume":"285","author":"AA Abdul-Sater","year":"2010","unstructured":"Abdul-Sater, A. A., et al. (2010). Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. The Journal of Biological Chemistry, 285(53), 41637\u201341645.","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"4_CR2","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.immuni.2017.03.020","volume":"46","author":"T Abe","year":"2017","unstructured":"Abe, T., et al. (2017). Germ-cell-specific inflammasome component NLRP14 negatively regulates cytosolic nucleic acid sensing to promote fertilization. Immunity, 46(4), 621\u2013634.","journal-title":"Immunity"},{"issue":"4","key":"4_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000361","volume":"5","author":"A Akhter","year":"2009","unstructured":"Akhter, A., et al. (2009). Caspase-7 activation by the Nlrc4\/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathogens, 5(4), e1000361.","journal-title":"PLoS Pathogens"},{"issue":"3","key":"4_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006177","volume":"13","author":"Z Al Nabhani","year":"2017","unstructured":"Al Nabhani, Z., et al. (2017). Nod2: The intestinal gate keeper. PLoS Pathogens, 13(3), e1006177.","journal-title":"PLoS Pathogens"},{"issue":"6","key":"4_CR5","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.immuni.2011.03.026","volume":"34","author":"IC Allen","year":"2011","unstructured":"Allen, I. C., et al. (2011). NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-\u03baB signaling pathways. Immunity, 34(6), 854\u2013865.","journal-title":"Immunity"},{"issue":"4","key":"4_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060842","volume":"8","author":"IC Allen","year":"2013","unstructured":"Allen, I. C., et al. (2013). Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PLoS One, 8(4), e60842.","journal-title":"PLoS One"},{"issue":"12","key":"4_CR7","doi-asserted-by":"publisher","first-page":"8099","DOI":"10.4049\/jimmunol.0900664","volume":"183","author":"CC Allison","year":"2009","unstructured":"Allison, C. C., et al. (2009). Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. Journal of Immunology (Baltimore, Md.: 1950), 183(12), 8099\u20138109.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"46","key":"4_CR8","doi-asserted-by":"publisher","first-page":"35217","DOI":"10.1074\/jbc.M604933200","volume":"281","author":"A Amer","year":"2006","unstructured":"Amer, A., et al. (2006). Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. The Journal of Biological Chemistry, 281(46), 35217\u201335223.","journal-title":"The Journal of Biological Chemistry"},{"issue":"7411","key":"4_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature11250","volume":"488","author":"PK Anand","year":"2012","unstructured":"Anand, P. K., et al. (2012). NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature, 488(7411), 389\u2013393.","journal-title":"Nature"},{"issue":"Pt 17","key":"4_CR10","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1242\/jcs.051193","volume":"122","author":"D Arnoult","year":"2009","unstructured":"Arnoult, D., et al. (2009). An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. Journal of Cell Science, 122(Pt 17), 3161\u20133168.","journal-title":"Journal of Cell Science"},{"issue":"84","key":"4_CR11","doi-asserted-by":"publisher","first-page":"eade7652","DOI":"10.1126\/sciimmunol.ade7652","volume":"8","author":"SH Baik","year":"2023","unstructured":"Baik, S. H., et al. (2023). Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation. Science Immunology, 8(84), eade7652.","journal-title":"Science Immunology"},{"issue":"3","key":"4_CR12","doi-asserted-by":"publisher","first-page":"e202000664","DOI":"10.26508\/lsa.202000664","volume":"3","author":"DP Ball","year":"2020","unstructured":"Ball, D. P., et al. (2020). Caspase-1 interdomain linker cleavage is required for pyroptosis. Life Science Alliance, 3(3), e202000664.","journal-title":"Life Science Alliance"},{"issue":"6","key":"4_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000523","volume":"2","author":"F Barreau","year":"2007","unstructured":"Barreau, F., et al. (2007). CARD15\/NOD2 is required for Peyer\u2019s patches homeostasis in mice. PLoS One, 2(6), e523.","journal-title":"PLoS One"},{"key":"4_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100863","volume":"76","author":"R Bauer","year":"2020","unstructured":"Bauer, R., & Rauch, I. (2020). The NAIP\/NLRC4 inflammasome in infection and pathology. Molecular Aspects of Medicine, 76, 100863.","journal-title":"Molecular Aspects of Medicine"},{"issue":"4","key":"4_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106313","volume":"26","author":"S Bauer","year":"2023","unstructured":"Bauer, S., et al. (2023a). NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPAR\u03b3 target genes. iScience, 26(4), 106313.","journal-title":"iScience"},{"issue":"10","key":"4_CR16","doi-asserted-by":"publisher","first-page":"8595","DOI":"10.3390\/ijms24108595","volume":"24","author":"S Bauer","year":"2023","unstructured":"Bauer, S., et al. (2023b). NOD-like receptors-emerging links to obesity and associated morbidities. International Journal of Molecular Sciences, 24(10), 8595.","journal-title":"International Journal of Molecular Sciences"},{"issue":"19","key":"4_CR17","doi-asserted-by":"publisher","first-page":"12955","DOI":"10.1074\/jbc.274.19.12955","volume":"274","author":"J Bertin","year":"1999","unstructured":"Bertin, J., et al. (1999). Human CARD4 protein is a novel CED-4\/Apaf-1 cell death family member that activates NF-kappaB. The Journal of Biological Chemistry, 274(19), 12955\u201312958.","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"4_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006159","volume":"13","author":"M Bielaszewska","year":"2017","unstructured":"Bielaszewska, M., et al. (2017). Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathogens, 13(2), e1006159.","journal-title":"PLoS Pathogens"},{"issue":"4","key":"4_CR19","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1128\/IAI.00754-10","volume":"79","author":"H Bielig","year":"2011","unstructured":"Bielig, H., et al. (2011). NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 non-O139 strains is modulated by the quorum-sensing regulator HapR. Infection and Immunity, 79(4), 1418\u20131427.","journal-title":"Infection and Immunity"},{"issue":"9","key":"4_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004351","volume":"10","author":"H Bielig","year":"2014","unstructured":"Bielig, H., et al. (2014). The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling. PLoS Pathogens, 10(9), e1004351.","journal-title":"PLoS Pathogens"},{"issue":"3","key":"4_CR21","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1084\/jem.20172222","volume":"215","author":"D Boucher","year":"2018","unstructured":"Boucher, D., et al. (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215(3), 827\u2013840.","journal-title":"The Journal of Experimental Medicine"},{"issue":"17","key":"4_CR22","doi-asserted-by":"publisher","first-page":"11637","DOI":"10.1074\/jbc.M510275200","volume":"281","author":"PK Boughan","year":"2006","unstructured":"Boughan, P. K., et al. (2006). Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: Critical regulators of beta-defensins during Helicobacter pylori infection. The Journal of Biological Chemistry, 281(17), 11637\u201311648.","journal-title":"The Journal of Biological Chemistry"},{"issue":"7221","key":"4_CR23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature07450","volume":"456","author":"D Bouskra","year":"2008","unstructured":"Bouskra, D., et al. (2008). Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature, 456(7221), 507\u2013510.","journal-title":"Nature"},{"issue":"6","key":"4_CR24","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","volume":"8","author":"P Broz","year":"2010","unstructured":"Broz, P., et al. (2010). Differential requirement for caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host & Microbe, 8(6), 471\u2013483.","journal-title":"Cell Host & Microbe"},{"issue":"1","key":"4_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cell.2007.01.045","volume":"129","author":"J-M Bruey","year":"2007","unstructured":"Bruey, J.-M., et al. (2007). Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell, 129(1), 45\u201356.","journal-title":"Cell"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"1111611","DOI":"10.3389\/fimmu.2023.1111611","volume":"14","author":"M Burian","year":"2023","unstructured":"Burian, M., Schmidt, M. F., & Yazdi, A. S. (2023). The NLRP1 inflammasome in skin diseases. Frontiers in Immunology, 14, 1111611.","journal-title":"Frontiers in Immunology"},{"issue":"11","key":"4_CR27","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.4049\/jimmunol.1200195","volume":"188","author":"S Cai","year":"2012","unstructured":"Cai, S., et al. (2012). NLRC4 inflammasome-mediated production of IL-1\u03b2 modulates mucosal immunity in the lung against gram-negative bacterial infection. Journal of Immunology (Baltimore, Md.: 1950), 188(11), 5623\u20135635.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"11284","DOI":"10.1038\/ncomms11284","volume":"7","author":"J Canton","year":"2016","unstructured":"Canton, J., et al. (2016). Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages. Nature Communications, 7, 11284.","journal-title":"Nature Communications"},{"issue":"1","key":"4_CR29","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"M Cargnello","year":"2011","unstructured":"Cargnello, M., & Roux, P. P. (2011). Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiology and Molecular Biology Reviews, 75(1), 50\u201383.","journal-title":"Microbiology and Molecular Biology Reviews"},{"issue":"5","key":"4_CR30","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.cmet.2017.03.021","volume":"25","author":"JF Cavallari","year":"2017","unstructured":"Cavallari, J. F., et al. (2017). Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4. Cell Metabolism, 25(5), 1063\u20131074.e3.","journal-title":"Cell Metabolism"},{"issue":"4","key":"4_CR31","doi-asserted-by":"publisher","first-page":"E579","DOI":"10.1152\/ajpendo.00033.2020","volume":"318","author":"JF Cavallari","year":"2020","unstructured":"Cavallari, J. F., et al. (2020). Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice. American Journal of Physiology. Endocrinology and Metabolism, 318(4), E579\u2013E585.","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"10","key":"4_CR32","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.celrep.2017.02.027","volume":"18","author":"KL Chan","year":"2017","unstructured":"Chan, K. L., et al. (2017). Circulating NOD1 activators and hematopoietic NOD1 contribute to metabolic inflammation and insulin resistance. Cell Reports, 18(10), 2415\u20132426.","journal-title":"Cell Reports"},{"issue":"26","key":"4_CR33","doi-asserted-by":"publisher","first-page":"20147","DOI":"10.1074\/jbc.M110.115584","volume":"285","author":"GM Charri\u00e8re","year":"2010","unstructured":"Charri\u00e8re, G. M., et al. (2010). Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. The Journal of Biological Chemistry, 285(26), 20147\u201320154.","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"4_CR34","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/eji.201344135","volume":"44","author":"GY Chen","year":"2014","unstructured":"Chen, G. Y. (2014). Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis. European Journal of Immunology, 44(2), 321\u2013327.","journal-title":"European Journal of Immunology"},{"issue":"5","key":"4_CR35","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/ni.3690","volume":"18","author":"L Chen","year":"2017","unstructured":"Chen, L., et al. (2017a). NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nature Immunology, 18(5), 541\u2013551.","journal-title":"Nature Immunology"},{"issue":"8","key":"4_CR36","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/ni0817-951e","volume":"18","author":"L Chen","year":"2017","unstructured":"Chen, L., et al. (2017b). Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nature Immunology, 18(8), 951.","journal-title":"Nature Immunology"},{"issue":"11","key":"4_CR37","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/ni1117-1270b","volume":"18","author":"L Chen","year":"2017","unstructured":"Chen, L., et al. (2017c). Corrigendum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nature Immunology, 18(11), 1270.","journal-title":"Nature Immunology"},{"issue":"11","key":"4_CR38","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1007\/s10067-022-06292-y","volume":"41","author":"S Chen","year":"2022","unstructured":"Chen, S., et al. (2022). Rare mutations in NLRP3 and NLRP12 associated with familial cold autoinflammatory syndrome: Two Chinese pedigrees. Clinical Rheumatology, 41(11), 3461\u20133470.","journal-title":"Clinical Rheumatology"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.3389\/fimmu.2019.02431","volume":"10","author":"X Chu","year":"2019","unstructured":"Chu, X., Wu, S., & Raju, R. (2019). NLRX1 regulation following acute mitochondrial injury. Frontiers in Immunology, 10, 2431.","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"4_CR40","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1172\/JCI66142","volume":"123","author":"TS Cohen","year":"2013","unstructured":"Cohen, T. S., & Prince, A. S. (2013). Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. The Journal of Clinical Investigation, 123(4), 1630\u20131637.","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"4_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nm.2069","volume":"16","author":"R Cooney","year":"2010","unstructured":"Cooney, R., et al. (2010). NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nature Medicine, 16(1), 90\u201397.","journal-title":"Nature Medicine"},{"issue":"2","key":"4_CR42","first-page":"700","volume":"123","author":"A Couturier-Maillard","year":"2013","unstructured":"Couturier-Maillard, A., et al. (2013). NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. The Journal of Clinical Investigation, 123(2), 700\u2013711.","journal-title":"The Journal of Clinical Investigation"},{"issue":"9","key":"4_CR43","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1073\/pnas.1121286109","volume":"109","author":"EA Creasey","year":"2012","unstructured":"Creasey, E. A., & Isberg, R. R. (2012). The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3481\u20133486.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"4_CR44","first-page":"48","volume":"76","author":"JRF Cummings","year":"2010","unstructured":"Cummings, J. R. F., et al. (2010). The genetics of NOD-like receptors in Crohn\u2019s disease. Tissue Antigens, 76(1), 48\u201356.","journal-title":"Tissue Antigens"},{"issue":"11","key":"4_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027396","volume":"6","author":"A D\u2019Osualdo","year":"2011","unstructured":"D\u2019Osualdo, A., et al. (2011). CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS One, 6(11), e27396.","journal-title":"PLoS One"},{"issue":"1","key":"4_CR46","doi-asserted-by":"publisher","first-page":"e2015632118","DOI":"10.1073\/pnas.2015632118","volume":"118","author":"J Dagvadorj","year":"2021","unstructured":"Dagvadorj, J., et al. (2021). Recruitment of pro-IL-1\u03b1 to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. Proceedings of the National Academy of Sciences of the United States of America, 118(1), e2015632118.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"4_CR47","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1053\/j.gastro.2011.06.080","volume":"141","author":"G Dalmasso","year":"2011","unstructured":"Dalmasso, G., et al. (2011). The PepT1-NOD2 signaling pathway aggravates induced colitis in mice. Gastroenterology, 141(4), 1334\u20131345.","journal-title":"Gastroenterology"},{"issue":"8","key":"4_CR48","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1002\/eji.201646401","volume":"46","author":"A Damm","year":"2016","unstructured":"Damm, A., et al. (2016). Epidermal NLRP10 contributes to contact hypersensitivity responses in mice. European Journal of Immunology, 46(8), 1959\u20131969.","journal-title":"European Journal of Immunology"},{"issue":"3","key":"4_CR49","doi-asserted-by":"publisher","first-page":"259","DOI":"10.15252\/emmm.201404169","volume":"7","author":"E Denou","year":"2015","unstructured":"Denou, E., et al. (2015). Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance. EMBO Molecular Medicine, 7(3), 259\u2013274.","journal-title":"EMBO Molecular Medicine"},{"issue":"1","key":"4_CR50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng1065","volume":"33","author":"E Diez","year":"2003","unstructured":"Diez, E., et al. (2003). Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nature Genetics, 33(1), 55\u201360.","journal-title":"Nature Genetics"},{"issue":"20","key":"4_CR51","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1182\/blood-2013-08-518282","volume":"122","author":"CA Dinarello","year":"2013","unstructured":"Dinarello, C. A. (2013). The C3a receptor, caspase-1, and release of IL-1\u03b2. Blood, 122(20), 3394\u20133395.","journal-title":"Blood"},{"issue":"7610","key":"4_CR52","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature18590","volume":"535","author":"J Ding","year":"2016","unstructured":"Ding, J., et al. (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature, 535(7610), 111\u2013116.","journal-title":"Nature"},{"issue":"5","key":"4_CR53","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","volume":"13","author":"DR Donohoe","year":"2011","unstructured":"Donohoe, D. R., et al. (2011). The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metabolism, 13(5), 517\u2013526.","journal-title":"Cell Metabolism"},{"issue":"7293","key":"4_CR54","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell, P., et al. (2010). NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature, 464(7293), 1357\u20131361.","journal-title":"Nature"},{"issue":"19","key":"4_CR55","doi-asserted-by":"publisher","first-page":"8041","DOI":"10.1073\/pnas.0611496104","volume":"104","author":"JA Duncan","year":"2007","unstructured":"Duncan, J. A., et al. (2007). Cryopyrin\/NALP3 binds ATP\/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proceedings of the National Academy of Sciences of the United States of America, 104(19), 8041\u20138046.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"4_CR56","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216184","volume":"80","author":"C Eijkelboom","year":"2021","unstructured":"Eijkelboom, C., et al. (2021). Response to: \u201cNovel NLRP12 variant presenting with familial cold autoimmunity syndrome phenotype\u201d by Gupta et al. Annals of the Rheumatic Diseases, 80(7), e118.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"5","key":"4_CR57","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","volume":"145","author":"E Elinav","year":"2011","unstructured":"Elinav, E., et al. (2011). NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell, 145(5), 745\u2013757.","journal-title":"Cell"},{"issue":"4","key":"4_CR58","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.immuni.2018.04.002","volume":"48","author":"E Elinav","year":"2018","unstructured":"Elinav, E., et al. (2018). NLRP6 and dysbiosis: Avoiding the luring attraction of over-simplification. Immunity, 48(4), 603\u2013604.","journal-title":"Immunity"},{"issue":"8","key":"4_CR59","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1074\/jbc.RA117.000152","volume":"293","author":"K Ellwanger","year":"2018","unstructured":"Ellwanger, K., et al. (2018). The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling. The Journal of Biological Chemistry, 293(8), 2701\u20132710.","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"4_CR60","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1128\/IAI.01170-13","volume":"82","author":"SE Ewald","year":"2014","unstructured":"Ewald, S. E., Chavarria-Smith, J., & Boothroyd, J. C. (2014). NLRP1 is an inflammasome sensor for Toxoplasma gondii. Infection and Immunity, 82(1), 460\u2013468.","journal-title":"Infection and Immunity"},{"issue":"1","key":"4_CR61","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan, Y., & Pedersen, O. (2021). Gut microbiota in human metabolic health and disease. Nature Reviews. Microbiology, 19(1), 55\u201371.","journal-title":"Nature Reviews. Microbiology"},{"issue":"10","key":"4_CR62","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1073\/pnas.0809414106","volume":"106","author":"B Faustin","year":"2009","unstructured":"Faustin, B., et al. (2009). Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization. Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3935\u20133940.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"4_CR63","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1001\/archinte.1990.00390220082016","volume":"150","author":"WM Feinberg","year":"1990","unstructured":"Feinberg, W. M., et al. (1990). Epidemiologic features of asymptomatic cerebral infarction in patients with nonvalvular atrial fibrillation. Archives of Internal Medicine, 150(11), 2340\u20132344.","journal-title":"Archives of Internal Medicine"},{"issue":"3","key":"4_CR64","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3390\/ijms22031316","volume":"22","author":"T Fekete","year":"2021","unstructured":"Fekete, T., et al. (2021). Focusing on the cell type specific regulatory actions of NLRX1. International Journal of Molecular Sciences, 22(3), 1316.","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"4_CR65","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.mayocp.2017.04.010","volume":"92","author":"JD Feuerstein","year":"2017","unstructured":"Feuerstein, J. D., & Cheifetz, A. S. (2017). Crohn disease: Epidemiology, diagnosis, and management. Mayo Clinic Proceedings, 92(7), 1088\u20131103.","journal-title":"Mayo Clinic Proceedings"},{"issue":"30","key":"4_CR66","doi-asserted-by":"publisher","first-page":"25030","DOI":"10.1074\/jbc.M112.378323","volume":"287","author":"JN Finger","year":"2012","unstructured":"Finger, J. N., et al. (2012). Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity. The Journal of Biological Chemistry, 287(30), 25030\u201325037.","journal-title":"The Journal of Biological Chemistry"},{"issue":"11","key":"4_CR67","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1073\/pnas.0707370105","volume":"105","author":"SL Fink","year":"2008","unstructured":"Fink, S. L., Bergsbaken, T., & Cookson, B. T. (2008). Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4312\u20134317.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"4_CR68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002659","volume":"8","author":"BC Frew","year":"2012","unstructured":"Frew, B. C., Joag, V. R., & Mogridge, J. (2012). Proteolytic processing of Nlrp1b is required for inflammasome activity. PLoS Pathogens, 8(4), e1002659.","journal-title":"PLoS Pathogens"},{"issue":"11","key":"4_CR69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000228","volume":"4","author":"A Fukazawa","year":"2008","unstructured":"Fukazawa, A., et al. (2008). GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathogens, 4(11), e1000228.","journal-title":"PLoS Pathogens"},{"issue":"5A","key":"4_CR70","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1111\/j.1582-4934.2007.00190.x","volume":"12","author":"M Galle","year":"2008","unstructured":"Galle, M., et al. (2008). The Pseudomonas aeruginosa type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. Journal of Cellular and Molecular Medicine, 12(5A), 1767\u20131776.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"6","key":"4_CR71","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/s41590-022-01220-3","volume":"23","author":"A Gangopadhyay","year":"2022","unstructured":"Gangopadhyay, A., et al. (2022). NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nature Immunology, 23(6), 892\u2013903.","journal-title":"Nature Immunology"},{"issue":"4","key":"4_CR72","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/1440-1681.12214","volume":"41","author":"T Gicquel","year":"2014","unstructured":"Gicquel, T., et al. (2014). Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages. Clinical and Experimental Pharmacology & Physiology, 41(4), 279\u2013286.","journal-title":"Clinical and Experimental Pharmacology & Physiology"},{"issue":"1","key":"4_CR73","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12974-018-1307-1","volume":"15","author":"E Gil-Varea","year":"2018","unstructured":"Gil-Varea, E., et al. (2018). Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course. Journal of Neuroinflammation, 15(1), 265.","journal-title":"Journal of Neuroinflammation"},{"issue":"5625","key":"4_CR74","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1126\/science.1084677","volume":"300","author":"SE Girardin","year":"2003","unstructured":"Girardin, S. E., et al. (2003a). Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (New York, N.Y.), 300(5625), 1584\u20131587.","journal-title":"Science (New York, N.Y.)"},{"issue":"11","key":"4_CR75","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","volume":"278","author":"SE Girardin","year":"2003","unstructured":"Girardin, S. E., et al. (2003b). Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. The Journal of Biological Chemistry, 278(11), 8869\u20138872.","journal-title":"The Journal of Biological Chemistry"},{"issue":"43","key":"4_CR76","doi-asserted-by":"publisher","first-page":"41702","DOI":"10.1074\/jbc.M307198200","volume":"278","author":"SE Girardin","year":"2003","unstructured":"Girardin, S. E., et al. (2003c). Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. The Journal of Biological Chemistry, 278(43), 41702\u201341708.","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"4_CR77","doi-asserted-by":"publisher","first-page":"e01117-13","DOI":"10.1128\/mBio.01117-13","volume":"5","author":"G Gorfu","year":"2014","unstructured":"Gorfu, G., et al. (2014). Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. MBio, 5(1), e01117-13.","journal-title":"MBio"},{"issue":"8","key":"4_CR78","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/intimm\/dxx047","volume":"29","author":"T Grandjean","year":"2017","unstructured":"Grandjean, T., et al. (2017). The human NAIP-NLRC4-inflammasome senses the Pseudomonas aeruginosa T3SS inner-rod protein. International Immunology, 29(8), 377\u2013384.","journal-title":"International Immunology"},{"issue":"1","key":"4_CR79","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00535-014-0958-7","volume":"50","author":"G Gremel","year":"2015","unstructured":"Gremel, G., et al. (2015). The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. Journal of Gastroenterology, 50(1), 46\u201357.","journal-title":"Journal of Gastroenterology"},{"issue":"5931","key":"4_CR80","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1171700","volume":"324","author":"EA Grice","year":"2009","unstructured":"Grice, E. A., et al. (2009). Topographical and temporal diversity of the human skin microbiome. Science (New York, N.Y.), 324(5931), 1190\u20131192.","journal-title":"Science (New York, N.Y.)"},{"issue":"5","key":"4_CR81","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1462-5822.2009.01421.x","volume":"12","author":"A Grubman","year":"2010","unstructured":"Grubman, A., et al. (2010). The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cellular Microbiology, 12(5), 626\u2013639.","journal-title":"Cellular Microbiology"},{"issue":"6","key":"4_CR82","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.ceb.2012.09.003","volume":"24","author":"Y Gu","year":"2012","unstructured":"Gu, Y., & Rosenblatt, J. (2012). New emerging roles for epithelial cell extrusion. Current Opinion in Cell Biology, 24(6), 865\u2013870.","journal-title":"Current Opinion in Cell Biology"},{"issue":"2","key":"4_CR83","doi-asserted-by":"publisher","first-page":"52","DOI":"10.31083\/j.rcm2302052","volume":"23","author":"K Guo","year":"2022","unstructured":"Guo, K., et al. (2022). Construction of a pyroptosis-related classifier for risk prediction of acute myocardial infarction. Reviews in Cardiovascular Medicine, 23(2), 52.","journal-title":"Reviews in Cardiovascular Medicine"},{"issue":"8","key":"4_CR84","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle, A., et al. (2008). The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nature Immunology, 9(8), 857\u2013865.","journal-title":"Nature Immunology"},{"issue":"1","key":"4_CR85","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4049\/jimmunol.168.1.57","volume":"168","author":"H Hamada","year":"2002","unstructured":"Hamada, H., et al. (2002). Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. Journal of Immunology (Baltimore, Md.: 1950), 168(1), 57\u201364.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"6","key":"4_CR86","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.cell.2018.09.047","volume":"175","author":"H Hara","year":"2018","unstructured":"Hara, H., et al. (2018). The NLRP6 inflammasome recognizes lipoteichoic acid and regulates gram-positive pathogen infection. Cell, 175(6), 1651\u20131664.e14.","journal-title":"Cell"},{"issue":"7","key":"4_CR87","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1128\/IAI.00296-13","volume":"81","author":"CR Harding","year":"2013","unstructured":"Harding, C. R., et al. (2013). The Dot\/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A\/J mice. Infection and Immunity, 81(7), 2598\u20132605.","journal-title":"Infection and Immunity"},{"issue":"6","key":"4_CR88","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/mi.2015.13","volume":"8","author":"OJ Harrison","year":"2015","unstructured":"Harrison, O. J., et al. (2015). Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine. Mucosal Immunology, 8(6), 1226\u20131236.","journal-title":"Mucosal Immunology"},{"issue":"2","key":"4_CR89","doi-asserted-by":"publisher","first-page":"R54","DOI":"10.1186\/bcr3155","volume":"14","author":"C He","year":"2012","unstructured":"He, C., et al. (2012). Reproductive aging-associated common genetic variants and the risk of breast cancer. Breast Cancer Research: BCR, 14(2), R54.","journal-title":"Breast Cancer Research: BCR"},{"issue":"12","key":"4_CR90","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"W-t He","year":"2015","unstructured":"He, W.-t., et al. (2015). Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Research, 25(12), 1285\u20131298.","journal-title":"Cell Research"},{"issue":"7590","key":"4_CR91","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He, Y., et al. (2016). NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature, 530(7590), 354\u2013357.","journal-title":"Nature"},{"issue":"3","key":"4_CR92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030051","volume":"3","author":"AA Herskovits","year":"2007","unstructured":"Herskovits, A. A., Auerbuch, V., & Portnoy, D. A. (2007). Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathogens, 3(3), e51.","journal-title":"PLoS Pathogens"},{"issue":"11","key":"4_CR93","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/ng.2438","volume":"44","author":"T Hirota","year":"2012","unstructured":"Hirota, T., et al. (2012). Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nature Genetics, 44(11), 1222\u20131226.","journal-title":"Nature Genetics"},{"issue":"4","key":"4_CR94","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1053\/gast.2003.50153","volume":"124","author":"T Hisamatsu","year":"2003","unstructured":"Hisamatsu, T., et al. (2003). CARD15\/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology, 124(4), 993\u20131000.","journal-title":"Gastroenterology"},{"issue":"7856","key":"4_CR95","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41586-021-03350-4","volume":"592","author":"LR Hollingsworth","year":"2021","unstructured":"Hollingsworth, L. R., et al. (2021). DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592(7856), 778\u2013783.","journal-title":"Nature"},{"issue":"5","key":"4_CR96","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1053\/j.gastro.2010.07.006","volume":"139","author":"CR Homer","year":"2010","unstructured":"Homer, C. R., et al. (2010). ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn\u2019s disease pathogenesis. Gastroenterology, 139(5), 1630\u20131641, 1641.e1\u20132.","journal-title":"Gastroenterology"},{"issue":"3","key":"4_CR97","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.immuni.2011.12.018","volume":"36","author":"M Hong","year":"2012","unstructured":"Hong, M., Yoon, S.-i., & Wilson, I. A. (2012). Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. Immunity, 36(3), 337\u2013347.","journal-title":"Immunity"},{"issue":"7856","key":"4_CR98","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41586-021-03320-w","volume":"592","author":"M Huang","year":"2021","unstructured":"Huang, M., et al. (2021). Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Nature, 592(7856), 773\u2013777.","journal-title":"Nature"},{"issue":"6837","key":"4_CR99","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot, J. P., et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature, 411(6837), 599\u2013603.","journal-title":"Nature"},{"issue":"10","key":"4_CR100","doi-asserted-by":"publisher","first-page":"5874","DOI":"10.4049\/jimmunol.0900779","volume":"184","author":"R Imamura","year":"2010","unstructured":"Imamura, R., et al. (2010). Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. Journal of Immunology (Baltimore, Md.: 1950), 184(10), 5874\u20135884.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"36","key":"4_CR101","doi-asserted-by":"publisher","first-page":"27823","DOI":"10.1074\/jbc.M003415200","volume":"275","author":"N Inohara","year":"2000","unstructured":"Inohara, N., et al. (2000). An induced proximity model for NF-kappa B activation in the Nod1\/RICK and RIP signaling pathways. The Journal of Biological Chemistry, 275(36), 27823\u201327831.","journal-title":"The Journal of Biological Chemistry"},{"issue":"8","key":"4_CR102","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","volume":"278","author":"N Inohara","year":"2003","unstructured":"Inohara, N., et al. (2003). Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn\u2019s disease. The Journal of Biological Chemistry, 278(8), 5509\u20135512.","journal-title":"The Journal of Biological Chemistry"},{"issue":"5","key":"4_CR103","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.chom.2014.04.001","volume":"15","author":"AT Irving","year":"2014","unstructured":"Irving, A. T., et al. (2014). The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling. Cell Host & Microbe, 15(5), 623\u2013635.","journal-title":"Cell Host & Microbe"},{"issue":"12","key":"4_CR104","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1139\/y06-076","volume":"84","author":"MG Ismair","year":"2006","unstructured":"Ismair, M. G., et al. (2006). hPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides. Canadian Journal of Physiology and Pharmacology, 84(12), 1313\u20131319.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"7","key":"4_CR105","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.4049\/jimmunol.1004058","volume":"186","author":"JK Iyer","year":"2011","unstructured":"Iyer, J. K., & Coggeshall, K. M. (2011). Cutting edge: Primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers. Journal of Immunology (Baltimore, Md.: 1950), 186(7), 3841\u20133845.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"1","key":"4_CR106","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cell.2019.12.016","volume":"180","author":"A Jarret","year":"2020","unstructured":"Jarret, A., et al. (2020). Enteric nervous system-derived IL-18 orchestrates mucosal barrier immunity. Cell, 180(1), 50\u201363.e12.","journal-title":"Cell"},{"issue":"1","key":"4_CR107","doi-asserted-by":"publisher","first-page":"2226916","DOI":"10.1080\/19490976.2023.2226916","volume":"15","author":"K Jaswal","year":"2023","unstructured":"Jaswal, K., Todd, O. A., & Behnsen, J. (2023). Neglected gut microbiome: Interactions of the non-bacterial gut microbiota with enteric pathogens. Gut Microbes, 15(1), 2226916.","journal-title":"Gut Microbes"},{"issue":"20","key":"4_CR108","first-page":"E2110-9","volume":"111","author":"J Jaworska","year":"2014","unstructured":"Jaworska, J., et al. (2014). NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein. Proceedings of the National Academy of Sciences of the United States of America, 111(20), E2110-9.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"4_CR109","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1056\/NEJMoa061592","volume":"356","author":"Y Jin","year":"2007","unstructured":"Jin, Y., et al. (2007). NALP1 in vitiligo-associated multiple autoimmune disease. The New England Journal of Medicine, 356(12), 1216\u20131225.","journal-title":"The New England Journal of Medicine"},{"issue":"7","key":"4_CR110","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/1873-3468.14302","volume":"596","author":"Y Kamitsukasa","year":"2022","unstructured":"Kamitsukasa, Y., et al. (2022). The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function. FEBS Letters, 596(7), 876\u2013885.","journal-title":"FEBS Letters"},{"issue":"12","key":"4_CR111","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/pros.22483","volume":"72","author":"M-J Kang","year":"2012","unstructured":"Kang, M.-J., et al. (2012). Activation of Nod1 and Nod2 induces innate immune responses of prostate epithelial cells. The Prostate, 72(12), 1351\u20131358.","journal-title":"The Prostate"},{"issue":"3","key":"4_CR112","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/j.1462-5822.2009.01404.x","volume":"12","author":"M Kaparakis","year":"2010","unstructured":"Kaparakis, M., et al. (2010). Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cellular Microbiology, 12(3), 372\u2013385.","journal-title":"Cellular Microbiology"},{"issue":"2","key":"4_CR113","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cyto.2015.02.018","volume":"74","author":"M Kaparakis-Liaskos","year":"2015","unstructured":"Kaparakis-Liaskos, M. (2015). The intracellular location, mechanisms and outcomes of NOD1 signaling. Cytokine, 74(2), 207\u2013212.","journal-title":"Cytokine"},{"issue":"13","key":"4_CR114","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.micinf.2012.03.006","volume":"14","author":"N Katagiri","year":"2012","unstructured":"Katagiri, N., et al. (2012). The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila. Microbes and Infection, 14(13), 1123\u20131132.","journal-title":"Microbes and Infection"},{"issue":"7371","key":"4_CR115","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature10558","volume":"479","author":"N Kayagaki","year":"2011","unstructured":"Kayagaki, N., et al. (2011). Non-canonical inflammasome activation targets caspase-11. Nature, 479(7371), 117\u2013121.","journal-title":"Nature"},{"issue":"7575","key":"4_CR116","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki, N., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature, 526(7575), 666\u2013671.","journal-title":"Nature"},{"issue":"6","key":"4_CR117","doi-asserted-by":"publisher","first-page":"e00266-11","DOI":"10.1128\/mBio.00266-11","volume":"2","author":"AM Keestra","year":"2011","unstructured":"Keestra, A. M., et al. (2011). A Salmonella virulence factor activates the NOD1\/NOD2 signaling pathway. MBio, 2(6), e00266-11.","journal-title":"MBio"},{"issue":"7444","key":"4_CR118","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nature12025","volume":"496","author":"AM Keestra","year":"2013","unstructured":"Keestra, A. M., et al. (2013). Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1. Nature, 496(7444), 233\u2013237.","journal-title":"Nature"},{"issue":"7599","key":"4_CR119","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature17631","volume":"532","author":"AM Keestra-Gounder","year":"2016","unstructured":"Keestra-Gounder, A. M., et al. (2016). NOD1 and NOD2 signalling links ER stress with inflammation. Nature, 532(7599), 394\u2013397.","journal-title":"Nature"},{"issue":"15","key":"4_CR120","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.molcel.2022.06.004","volume":"82","author":"SA Killackey","year":"2022","unstructured":"Killackey, S. A., et al. (2022). Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1. Molecular Cell, 82(15), 2815\u20132831.e5.","journal-title":"Molecular Cell"},{"issue":"6877","key":"4_CR121","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/416194a","volume":"416","author":"K Kobayashi","year":"2002","unstructured":"Kobayashi, K., et al. (2002). RICK\/Rip2\/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature, 416(6877), 194\u2013199.","journal-title":"Nature"},{"issue":"5710","key":"4_CR122","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1126\/science.1104911","volume":"307","author":"KS Kobayashi","year":"2005","unstructured":"Kobayashi, K. S., et al. (2005). Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (New York, N.Y.), 307(5710), 731\u2013734.","journal-title":"Science (New York, N.Y.)"},{"issue":"7366","key":"4_CR123","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nature10394","volume":"477","author":"EM Kofoed","year":"2011","unstructured":"Kofoed, E. M., & Vance, R. E. (2011). Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature, 477(7366), 592\u2013595.","journal-title":"Nature"},{"key":"4_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120845","volume":"274","author":"J-H Koo","year":"2021","unstructured":"Koo, J.-H., et al. (2021). Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-\u03baB and inflammasome signaling activation. Biomaterials, 274, 120845.","journal-title":"Biomaterials"},{"issue":"13","key":"4_CR125","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1084\/jem.20160900","volume":"213","author":"AA Kuchmiy","year":"2016","unstructured":"Kuchmiy, A. A., et al. (2016). NLRP2 controls age-associated maternal fertility. The Journal of Experimental Medicine, 213(13), 2851\u20132860.","journal-title":"The Journal of Experimental Medicine"},{"key":"4_CR126","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1196\/annals.1326.020","volume":"1072","author":"TA Kufer","year":"2006","unstructured":"Kufer, T. A., Banks, D. J., & Philpott, D. J. (2006). Innate immune sensing of microbes by Nod proteins. Annals of the New York Academy of Sciences, 1072, 19\u201327.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"2","key":"4_CR127","first-page":"477","volume":"10","author":"TA Kufer","year":"2008","unstructured":"Kufer, T. A., et al. (2008). The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cellular Microbiology, 10(2), 477\u2013486.","journal-title":"Cellular Microbiology"},{"issue":"10","key":"4_CR128","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.it.2019.08.001","volume":"40","author":"TA Kufer","year":"2019","unstructured":"Kufer, T. A., Creagh, E. M., & Bryant, C. E. (2019). Guardians of the cell: Effector-triggered immunity steers mammalian immune defense. Trends in Immunology, 40(10), 939\u2013951.","journal-title":"Trends in Immunology"},{"key":"4_CR129","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev.micro.091208.073413","volume":"64","author":"A Kulp","year":"2010","unstructured":"Kulp, A., & Kuehn, M. J. (2010). Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annual Review of Microbiology, 64, 163\u2013184.","journal-title":"Annual Review of Microbiology"},{"issue":"1","key":"4_CR130","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.200903124","volume":"187","author":"M Lamkanfi","year":"2009","unstructured":"Lamkanfi, M., et al. (2009). Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome. The Journal of Cell Biology, 187(1), 61\u201370.","journal-title":"The Journal of Cell Biology"},{"issue":"10","key":"4_CR131","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1111\/j.1462-5822.2012.01822.x","volume":"14","author":"K Lautz","year":"2012","unstructured":"Lautz, K., et al. (2012). NLRP10 enhances Shigella-induced pro-inflammatory responses. Cellular Microbiology, 14(10), 1568\u20131583.","journal-title":"Cellular Microbiology"},{"issue":"3","key":"4_CR132","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.chom.2008.02.004","volume":"3","author":"PM LeBlanc","year":"2008","unstructured":"LeBlanc, P. M., et al. (2008). Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host & Microbe, 3(3), 146\u2013157.","journal-title":"Cell Host & Microbe"},{"issue":"9","key":"4_CR133","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/intimm\/dxq058","volume":"22","author":"M Lech","year":"2010","unstructured":"Lech, M., et al. (2010). Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice. International Immunology, 22(9), 717\u2013728.","journal-title":"International Immunology"},{"issue":"35","key":"4_CR134","doi-asserted-by":"publisher","first-page":"23818","DOI":"10.1074\/jbc.M109.033670","volume":"284","author":"J Lee","year":"2009","unstructured":"Lee, J., et al. (2009). pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. The Journal of Biological Chemistry, 284(35), 23818\u201323829.","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"4_CR135","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.immuni.2012.03.025","volume":"36","author":"Y Lei","year":"2012","unstructured":"Lei, Y., et al. (2012). The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity, 36(6), 933\u2013946.","journal-title":"Immunity"},{"issue":"6","key":"4_CR136","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","volume":"163","author":"M Levy","year":"2015","unstructured":"Levy, M., et al. (2015). Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell, 163(6), 1428\u20131443.","journal-title":"Cell"},{"issue":"3","key":"4_CR137","doi-asserted-by":"publisher","first-page":"e001824","DOI":"10.1136\/rmdopen-2021-001824","volume":"7","author":"D L\u00e9vy","year":"2021","unstructured":"L\u00e9vy, D., et al. (2021). Contrasting role of NLRP12 in autoinflammation: Evidence from a case report and mouse models. RMD Open, 7(3), e001824.","journal-title":"RMD Open"},{"issue":"2","key":"4_CR138","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1128\/IAI.01003-12","volume":"81","author":"K-C Liao","year":"2013","unstructured":"Liao, K.-C., & Mogridge, J. (2013). Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP. Infection and Immunity, 81(2), 570\u2013579.","journal-title":"Infection and Immunity"},{"key":"4_CR139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156055","volume":"160","author":"M Liu","year":"2022","unstructured":"Liu, M., et al. (2022). The regulatory role of NLRX1 in innate immunity and human disease. Cytokine, 160, 156055.","journal-title":"Cytokine"},{"issue":"1","key":"4_CR140","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1038\/s41467-019-10784-y","volume":"10","author":"P Luan","year":"2019","unstructured":"Luan, P., et al. (2019). NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR\u03b3. Nature Communications, 10(1), 2882.","journal-title":"Nature Communications"},{"key":"4_CR141","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.biopha.2017.03.062","volume":"91","author":"S-R Ma","year":"2017","unstructured":"Ma, S.-R., & Xie, X.-W. (2017). NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4\/NF-\u03baB. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 91, 755\u2013766.","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"18","key":"4_CR142","doi-asserted-by":"publisher","first-page":"10269","DOI":"10.3390\/ijms231810269","volume":"23","author":"DA Machtens","year":"2022","unstructured":"Machtens, D. A., et al. (2022). The inflammasome activity of NLRP3 is independent of NEK7 in HEK293 cells co-expressing ASC. International Journal of Molecular Sciences, 23(18), 10269.","journal-title":"International Journal of Molecular Sciences"},{"key":"4_CR143","doi-asserted-by":"publisher","first-page":"11813","DOI":"10.1038\/ncomms11813","volume":"7","author":"S Maekawa","year":"2016","unstructured":"Maekawa, S., et al. (2016). Crystal structure of NOD2 and its implications in human disease. Nature Communications, 7, 11813.","journal-title":"Nature Communications"},{"issue":"12","key":"4_CR144","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/sj.embor.7400552","volume":"6","author":"JG Magalhaes","year":"2005","unstructured":"Magalhaes, J. G., et al. (2005). Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Reports, 6(12), 1201\u20131207.","journal-title":"EMBO Reports"},{"issue":"5","key":"4_CR145","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/eji.201040827","volume":"41","author":"JG Magalhaes","year":"2011","unstructured":"Magalhaes, J. G., et al. (2011). Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. European Journal of Immunology, 41(5), 1445\u20131455.","journal-title":"European Journal of Immunology"},{"issue":"7","key":"4_CR146","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.4049\/jimmunol.0802197","volume":"182","author":"N Marina-Garc\u00eda","year":"2009","unstructured":"Marina-Garc\u00eda, N., et al. (2009). Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. Journal of Immunology (Baltimore, Md.: 1950), 182(7), 4321\u20134327.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"15","key":"4_CR147","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/1873-3468.13865","volume":"594","author":"M Marleaux","year":"2020","unstructured":"Marleaux, M., et al. (2020). Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly. FEBS Letters, 594(15), 2383\u20132395.","journal-title":"FEBS Letters"},{"issue":"2","key":"4_CR148","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon, F., Burns, K., & Tschopp, J. (2002). The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Molecular Cell, 10(2), 417\u2013426.","journal-title":"Molecular Cell"},{"issue":"7081","key":"4_CR149","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon, F., et al. (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature, 440(7081), 237\u2013241.","journal-title":"Nature"},{"issue":"10","key":"4_CR150","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ni.1935","volume":"11","author":"SL Masters","year":"2010","unstructured":"Masters, S. L., et al. (2010). Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1\u03b2 in type 2 diabetes. Nature Immunology, 11(10), 897\u2013904.","journal-title":"Nature Immunology"},{"issue":"5","key":"4_CR151","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/19490976.2018.1564430","volume":"10","author":"PHQS Medeiros","year":"2019","unstructured":"Medeiros, P. H. Q. S., et al. (2019). A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency. Gut Microbes, 10(5), 615\u2013630.","journal-title":"Gut Microbes"},{"issue":"31","key":"4_CR152","doi-asserted-by":"publisher","first-page":"13794","DOI":"10.1073\/pnas.1008684107","volume":"107","author":"TB Meissner","year":"2010","unstructured":"Meissner, T. B., et al. (2010). NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13794\u201313799.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"4_CR153","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","volume":"172","author":"J Mestas","year":"2004","unstructured":"Mestas, J., & Hughes, C. C. W. (2004). Of mice and not men: Differences between mouse and human immunology. Journal of Immunology (Baltimore, Md.: 1950), 172(5), 2731\u20132738.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"1","key":"4_CR154","doi-asserted-by":"publisher","first-page":"218","DOI":"10.4049\/jimmunol.1800334","volume":"202","author":"N Mirza","year":"2019","unstructured":"Mirza, N., et al. (2019). NLRP10 affects the stability of Abin-1 to control inflammatory responses. Journal of Immunology (Baltimore, Md.: 1950), 202(1), 218\u2013227.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"key":"4_CR155","doi-asserted-by":"publisher","first-page":"e59022","DOI":"10.7554\/eLife.59022","volume":"9","author":"PS Mitchell","year":"2020","unstructured":"Mitchell, P. S., et al. (2020). NAIP-NLRC4-deficient mice are susceptible to shigellosis. eLife, 9, e59022.","journal-title":"eLife"},{"issue":"5","key":"4_CR156","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.micinf.2011.12.005","volume":"14","author":"M Moayeri","year":"2012","unstructured":"Moayeri, M., Sastalla, I., & Leppla, S. H. (2012). Anthrax and the inflammasome. Microbes and Infection, 14(5), 392\u2013400.","journal-title":"Microbes and Infection"},{"key":"4_CR157","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-immunol-032712-095944","volume":"31","author":"J Moltke","year":"2013","unstructured":"Moltke, J., et al. (2013). Recognition of bacteria by inflammasomes. Annual Review of Immunology, 31, 73\u2013106.","journal-title":"Annual Review of Immunology"},{"key":"4_CR158","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2021.607385","volume":"27","author":"SW Moon","year":"2021","unstructured":"Moon, S. W., et al. (2021). Somatic mutation of NLRP genes in gastric and colonic cancers. Pathology Oncology Research: POR, 27, 607385.","journal-title":"Pathology Oncology Research: POR"},{"issue":"1","key":"4_CR159","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1152\/physrev.00009.2014","volume":"95","author":"V Motta","year":"2015","unstructured":"Motta, V., et al. (2015). NOD-like receptors: Versatile cytosolic sentinels. Physiological Reviews, 95(1), 149\u2013178.","journal-title":"Physiological Reviews"},{"issue":"7","key":"4_CR160","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1136\/jmedgenet-2018-105936","volume":"56","author":"J Mu","year":"2019","unstructured":"Mu, J., et al. (2019). Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest. Journal of Medical Genetics, 56(7), 471\u2013480.","journal-title":"Journal of Medical Genetics"},{"issue":"10","key":"4_CR161","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1093\/emboj\/16.10.2851","volume":"16","author":"A Muhlethaler-Mottet","year":"1997","unstructured":"Muhlethaler-Mottet, A., et al. (1997). Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. The EMBO Journal, 16(10), 2851\u20132860.","journal-title":"The EMBO Journal"},{"key":"4_CR162","doi-asserted-by":"publisher","first-page":"24641","DOI":"10.3402\/jev.v3.24641","volume":"3","author":"LA Mulcahy","year":"2014","unstructured":"Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014). Routes and mechanisms of extracellular vesicle uptake. Journal of Extracellular Vesicles, 3, 24641.","journal-title":"Journal of Extracellular Vesicles"},{"issue":"6","key":"4_CR163","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3390\/microorganisms11061484","volume":"11","author":"B Murphy","year":"2023","unstructured":"Murphy, B., et al. (2023). Compositional variations between adult and infant skin microbiome: An update. Microorganisms, 11(6), 1484.","journal-title":"Microorganisms"},{"issue":"3","key":"4_CR164","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/jnc.13197","volume":"135","author":"P Nagy\u0151szi","year":"2015","unstructured":"Nagy\u0151szi, P., et al. (2015). Regulation of NOD-like receptors and inflammasome activation in cerebral endothelial cells. Journal of Neurochemistry, 135(3), 551\u2013564.","journal-title":"Journal of Neurochemistry"},{"issue":"7499","key":"4_CR165","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nature13133","volume":"509","author":"N Nakamura","year":"2014","unstructured":"Nakamura, N., et al. (2014). Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature, 509(7499), 240\u2013244.","journal-title":"Nature"},{"issue":"2","key":"4_CR166","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1128\/CMR.00052-09","volume":"23","author":"HJ Newton","year":"2010","unstructured":"Newton, H. J., et al. (2010). Molecular pathogenesis of infections caused by Legionella pneumophila. Clinical Microbiology Reviews, 23(2), 274\u2013298.","journal-title":"Clinical Microbiology Reviews"},{"issue":"3","key":"4_CR167","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1462-5822.2007.01075.x","volume":"10","author":"G Nigro","year":"2008","unstructured":"Nigro, G., et al. (2008). Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cellular Microbiology, 10(3), 682\u2013695.","journal-title":"Cellular Microbiology"},{"issue":"6","key":"4_CR168","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.chom.2014.05.003","volume":"15","author":"G Nigro","year":"2014","unstructured":"Nigro, G., et al. (2014). The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host & Microbe, 15(6), 792\u2013798.","journal-title":"Cell Host & Microbe"},{"issue":"1","key":"4_CR169","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/imm.13267","volume":"162","author":"S Nizami","year":"2021","unstructured":"Nizami, S., et al. (2021). Inhibition of the NLRP3 inflammasome by HSP90 inhibitors. Immunology, 162(1), 84\u201391.","journal-title":"Immunology"},{"issue":"1","key":"4_CR170","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.1038\/s41467-018-07750-5","volume":"9","author":"S Normand","year":"2018","unstructured":"Normand, S., et al. (2018). Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nature Communications, 9(1), 5338.","journal-title":"Nature Communications"},{"key":"4_CR171","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bbi.2017.04.010","volume":"64","author":"\u00c1 Ny\u00fal-T\u00f3th","year":"2017","unstructured":"Ny\u00fal-T\u00f3th, \u00c1., et al. (2017). Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes. Brain, Behavior, and Immunity, 64, 220\u2013231.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"7","key":"4_CR172","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1074\/jbc.M008072200","volume":"276","author":"Y Ogura","year":"2001","unstructured":"Ogura, Y., et al. (2001). Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. The Journal of Biological Chemistry, 276(7), 4812\u20134818.","journal-title":"The Journal of Biological Chemistry"},{"issue":"11","key":"4_CR173","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1136\/gut.52.11.1591","volume":"52","author":"Y Ogura","year":"2003","unstructured":"Ogura, Y., et al. (2003). Expression of NOD2 in Paneth cells: A possible link to Crohn\u2019s ileitis. Gut, 52(11), 1591\u20131597.","journal-title":"Gut"},{"issue":"3","key":"4_CR174","doi-asserted-by":"publisher","first-page":"e00979-14","DOI":"10.1128\/mBio.00979-14","volume":"5","author":"A Olofsson","year":"2014","unstructured":"Olofsson, A., et al. (2014). Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways. MBio, 5(3), e00979-14.","journal-title":"MBio"},{"issue":"1","key":"4_CR175","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1080\/27694127.2022.2119743","volume":"1","author":"A Pant","year":"2022","unstructured":"Pant, A., et al. (2022). Interactions of autophagy and the immune system in health and diseases. Autophagy Reports, 1(1), 438\u2013515.","journal-title":"Autophagy Reports"},{"issue":"13","key":"4_CR176","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106272","volume":"40","author":"G Pei","year":"2021","unstructured":"Pei, G., et al. (2021). Cellular stress promotes NOD1\/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate. The EMBO Journal, 40(13), e106272.","journal-title":"The EMBO Journal"},{"issue":"21","key":"4_CR177","doi-asserted-by":"publisher","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","volume":"269","author":"D Perregaux","year":"1994","unstructured":"Perregaux, D., & Gabel, C. A. (1994). Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. The Journal of Biological Chemistry, 269(21), 15195\u201315203.","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"4_CR178","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.bpg.2003.12.004","volume":"18","author":"DJ Philpott","year":"2004","unstructured":"Philpott, D. J., & Viala, J. (2004). Towards an understanding of the role of NOD2\/CARD15 in the pathogenesis of Crohn\u2019s disease. Best Practice & Research. Clinical Gastroenterology, 18(3), 555\u2013568.","journal-title":"Best Practice & Research. Clinical Gastroenterology"},{"issue":"35","key":"4_CR179","doi-asserted-by":"publisher","first-page":"27402","DOI":"10.1074\/jbc.M110.113191","volume":"285","author":"AS Pinheiro","year":"2010","unstructured":"Pinheiro, A. S., et al. (2010). Three-dimensional structure of the NLRP7 pyrin domain: Insight into pyrin-pyrin-mediated effector domain signaling in innate immunity. The Journal of Biological Chemistry, 285(35), 27402\u201327410.","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"4_CR180","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jmb.2011.09.024","volume":"413","author":"AS Pinheiro","year":"2011","unstructured":"Pinheiro, A. S., et al. (2011). The NLRP12 pyrin domain: Structure, dynamics, and functional insights. Journal of Molecular Biology, 413(4), 790\u2013803.","journal-title":"Journal of Molecular Biology"},{"issue":"12","key":"4_CR181","doi-asserted-by":"publisher","first-page":"505.e1","DOI":"10.1016\/j.urolonc.2015.07.012","volume":"33","author":"G Poli","year":"2015","unstructured":"Poli, G., et al. (2015). Expression of inflammasome-related genes in bladder cancer and their association with cytokeratin 20 messenger RNA. Urologic Oncology, 33(12), 505.e1\u2013505.e7.","journal-title":"Urologic Oncology"},{"issue":"8","key":"4_CR182","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/embor.2012.96","volume":"13","author":"J Pott","year":"2012","unstructured":"Pott, J., & Hornef, M. (2012). Innate immune signalling at the intestinal epithelium in homeostasis and disease. EMBO Reports, 13(8), 684\u2013698.","journal-title":"EMBO Reports"},{"issue":"4","key":"4_CR183","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41590-023-01451-y","volume":"24","author":"T Pr\u00f3chnicki","year":"2023","unstructured":"Pr\u00f3chnicki, T., et al. (2023). Mitochondrial damage activates the NLRP10 inflammasome. Nature Immunology, 24(4), 595\u2013603.","journal-title":"Nature Immunology"},{"issue":"17","key":"4_CR184","doi-asserted-by":"publisher","first-page":"R784","DOI":"10.1016\/j.cub.2014.07.016","volume":"24","author":"A Puhar","year":"2014","unstructured":"Puhar, A., & Sansonetti, P. J. (2014). Type III secretion system. Current Biology: CB, 24(17), R784\u2013R791.","journal-title":"Current Biology: CB"},{"issue":"23","key":"4_CR185","doi-asserted-by":"publisher","first-page":"e01264-17","DOI":"10.1128\/JVI.01264-17","volume":"91","author":"Y Qin","year":"2017","unstructured":"Qin, Y., et al. (2017). NLRX1 mediates MAVS degradation to attenuate the hepatitis C virus-induced innate immune response through PCBP2. Journal of Virology, 91(23), e01264-17.","journal-title":"Journal of Virology"},{"issue":"2","key":"4_CR186","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.immuni.2014.06.015","volume":"41","author":"D Ramanan","year":"2014","unstructured":"Ramanan, D., et al. (2014). Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity, 41(2), 311\u2013324.","journal-title":"Immunity"},{"issue":"4","key":"4_CR187","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ni.2237","volume":"13","author":"VAK Rathinam","year":"2012","unstructured":"Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012). Regulation of inflammasome signaling. Nature Immunology, 13(4), 333\u2013342.","journal-title":"Nature Immunology"},{"issue":"4","key":"4_CR188","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","volume":"46","author":"I Rauch","year":"2017","unstructured":"Rauch, I., et al. (2017). NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8. Immunity, 46(4), 649\u2013659.","journal-title":"Immunity"},{"issue":"5","key":"4_CR189","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrgastro.2017.43","volume":"14","author":"K Ray","year":"2017","unstructured":"Ray, K. (2017). Gut microbiota: NLRP12 regulates gut microbiota to suppress intestinal inflammation. Nature Reviews. Gastroenterology & Hepatology, 14(5), 260\u2013261.","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"3","key":"4_CR190","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4161\/gmic.24373","volume":"4","author":"SJ Robertson","year":"2013","unstructured":"Robertson, S. J., et al. (2013). Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis. Gut Microbes, 4(3), 222\u2013231.","journal-title":"Gut Microbes"},{"issue":"10","key":"4_CR191","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/ni.1782","volume":"10","author":"A Sabbah","year":"2009","unstructured":"Sabbah, A., et al. (2009). Activation of innate immune antiviral responses by Nod2. Nature Immunology, 10(10), 1073\u20131080.","journal-title":"Nature Immunology"},{"issue":"3","key":"4_CR192","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.chom.2018.08.010","volume":"24","author":"H Sadeghi","year":"2018","unstructured":"Sadeghi, H., Devkota, S., & Sutterwala, F. S. (2018). NLRP12: The monarch of the gut. Cell Host & Microbe, 24(3), 326\u2013328.","journal-title":"Cell Host & Microbe"},{"issue":"5","key":"4_CR193","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1053\/j.gastro.2011.01.041","volume":"140","author":"S Sasawatari","year":"2011","unstructured":"Sasawatari, S., et al. (2011). The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology, 140(5), 1513\u20131525.","journal-title":"Gastroenterology"},{"issue":"9","key":"4_CR194","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.2337\/db11-0004","volume":"60","author":"JD Schertzer","year":"2011","unstructured":"Schertzer, J. D., et al. (2011). NOD1 activators link innate immunity to insulin resistance. Diabetes, 60(9), 2206\u20132215.","journal-title":"Diabetes"},{"issue":"1","key":"4_CR195","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1074\/jbc.C115.700492","volume":"291","author":"JL Schmid-Burgk","year":"2016","unstructured":"Schmid-Burgk, J. L., et al. (2016). A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. The Journal of Biological Chemistry, 291(1), 103\u2013109.","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"4_CR196","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder, K., & Tschopp, J. (2010). The inflammasomes. Cell, 140(6), 821\u2013832.","journal-title":"Cell"},{"issue":"2","key":"4_CR197","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","volume":"16","author":"ME Sellin","year":"2014","unstructured":"Sellin, M. E., et al. (2014). Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host & Microbe, 16(2), 237\u2013248.","journal-title":"Cell Host & Microbe"},{"issue":"8","key":"4_CR198","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.it.2015.06.002","volume":"36","author":"ME Sellin","year":"2015","unstructured":"Sellin, M. E., et al. (2015). Inflammasomes of the intestinal epithelium. Trends in Immunology, 36(8), 442\u2013450.","journal-title":"Trends in Immunology"},{"issue":"7","key":"4_CR199","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.immuni.2021.04.024","volume":"54","author":"H Sharif","year":"2021","unstructured":"Sharif, H., et al. (2021). Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity, 54(7), 1392\u20131404.e10.","journal-title":"Immunity"},{"issue":"4","key":"4_CR200","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","volume":"167","author":"G Sharon","year":"2016","unstructured":"Sharon, G., et al. (2016). The central nervous system and the gut microbiome. Cell, 167(4), 915\u2013932.","journal-title":"Cell"},{"issue":"3","key":"4_CR201","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058766","volume":"8","author":"C Shen","year":"2013","unstructured":"Shen, C., et al. (2013). Evaluating GWAS-identified SNPs for age at natural menopause among Chinese women. PLoS One, 8(3), e58766.","journal-title":"PLoS One"},{"issue":"7575","key":"4_CR202","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi, J., et al. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature, 526(7575), 660\u2013665.","journal-title":"Nature"},{"issue":"2","key":"4_CR203","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nri3141","volume":"12","author":"SH Spoel","year":"2012","unstructured":"Spoel, S. H., & Dong, X. (2012). How do plants achieve immunity? Defence without specialized immune cells. Nature Reviews. Immunology, 12(2), 89\u2013100.","journal-title":"Nature Reviews. Immunology"},{"issue":"3","key":"4_CR204","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/ng.1051","volume":"44","author":"L Stolk","year":"2012","unstructured":"Stolk, L., et al. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260\u2013268.","journal-title":"Nature Genetics"},{"issue":"3","key":"4_CR205","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nri3398","volume":"13","author":"LM Stuart","year":"2013","unstructured":"Stuart, L. M., Paquette, N., & Boyer, L. (2013). Effector-triggered versus pattern-triggered immunity: How animals sense pathogens. Nature Reviews. Immunology, 13(3), 199\u2013206.","journal-title":"Nature Reviews. Immunology"},{"issue":"13","key":"4_CR206","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1084\/jem.20071239","volume":"204","author":"FS Sutterwala","year":"2007","unstructured":"Sutterwala, F. S., et al. (2007). Immune recognition of Pseudomonas aeruginosa mediated by the IPAF\/NLRC4 inflammasome. The Journal of Experimental Medicine, 204(13), 3235\u20133245.","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"4_CR207","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.12458","volume":"1319","author":"FS Sutterwala","year":"2014","unstructured":"Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014). Mechanism of NLRP3 inflammasome activation. Annals of the New York Academy of Sciences, 1319(1), 82\u201395.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"2","key":"4_CR208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003926","volume":"10","author":"S Suzuki","year":"2014","unstructured":"Suzuki, S., et al. (2014). Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc\u03b4. PLoS Pathogens, 10(2), e1003926.","journal-title":"PLoS Pathogens"},{"issue":"5","key":"4_CR209","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1165\/rcmb.2008-0059OC","volume":"39","author":"PW Swaan","year":"2008","unstructured":"Swaan, P. W., et al. (2008). Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2. American Journal of Respiratory Cell and Molecular Biology, 39(5), 536\u2013542.","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"8","key":"4_CR210","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019). The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nature Reviews. Immunology, 19(8), 477\u2013489.","journal-title":"Nature Reviews. Immunology"},{"key":"4_CR211","doi-asserted-by":"publisher","first-page":"61","DOI":"10.17219\/acem\/163581","volume":"33","author":"J Tan","year":"2024","unstructured":"Tan, J., Li, J., & Zeng, Y. (2024). Low-level NLRP1 is associated with increased metastasis and risk of recurrence of non-melanoma skin cancer. Advances in Clinical and Experimental Medicine, 33, 61\u201368.","journal-title":"Advances in Clinical and Experimental Medicine"},{"issue":"7","key":"4_CR212","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1038\/sj.emboj.7600175","volume":"23","author":"T Tanabe","year":"2004","unstructured":"Tanabe, T., et al. (2004). Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. The EMBO Journal, 23(7), 1587\u20131597.","journal-title":"The EMBO Journal"},{"issue":"3","key":"4_CR213","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.embor.7401161","volume":"9","author":"I Tattoli","year":"2008","unstructured":"Tattoli, I., et al. (2008). NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Reports, 9(3), 293\u2013300.","journal-title":"EMBO Reports"},{"issue":"10","key":"4_CR214","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1128\/IAI.01980-14","volume":"82","author":"B Thay","year":"2014","unstructured":"Thay, B., et al. (2014). Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-\u03baB activation. Infection and Immunity, 82(10), 4034\u20134046.","journal-title":"Infection and Immunity"},{"key":"4_CR215","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/1471-2148-9-202","volume":"9","author":"X Tian","year":"2009","unstructured":"Tian, X., Pascal, G., & Monget, P. (2009). Evolution and functional divergence of NLRP genes in mammalian reproductive systems. BMC Evolutionary Biology, 9, 202.","journal-title":"BMC Evolutionary Biology"},{"issue":"3","key":"4_CR216","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2008.02.005","volume":"28","author":"JP-Y Ting","year":"2008","unstructured":"Ting, J. P.-Y., et al. (2008). The NLR gene family: A standard nomenclature. Immunity, 28(3), 285\u2013287.","journal-title":"Immunity"},{"issue":"12","key":"4_CR217","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1172\/JCI83260","volume":"125","author":"J Traba","year":"2015","unstructured":"Traba, J., et al. (2015). Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. The Journal of Clinical Investigation, 125(12), 4592\u20134600.","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"4_CR218","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ni.1823","volume":"11","author":"LH Travassos","year":"2010","unstructured":"Travassos, L. H., et al. (2010). Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nature Immunology, 11(1), 55\u201362.","journal-title":"Nature Immunology"},{"issue":"Pt 13","key":"4_CR219","first-page":"2903","volume":"126","author":"K Triantafilou","year":"2013","unstructured":"Triantafilou, K., et al. (2013). The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of Cell Science, 126(Pt 13), 2903\u20132913.","journal-title":"Journal of Cell Science"},{"issue":"3","key":"4_CR220","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.chom.2018.08.009","volume":"24","author":"AD Truax","year":"2018","unstructured":"Truax, A. D., et al. (2018). The inhibitory innate immune sensor NLRP12 maintains a threshold against obesity by regulating gut microbiota homeostasis. Cell Host & Microbe, 24(3), 364\u2013378.e6.","journal-title":"Cell Host & Microbe"},{"issue":"3","key":"4_CR221","doi-asserted-by":"publisher","first-page":"e157272","DOI":"10.1172\/JCI157272","volume":"133","author":"Y-P Tsao","year":"2023","unstructured":"Tsao, Y.-P., et al. (2023). NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression. The Journal of Clinical Investigation, 133(3), e157272.","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"4_CR222","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.smim.2007.12.003","volume":"20","author":"M Tsuji","year":"2008","unstructured":"Tsuji, M., et al. (2008). Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis. Seminars in Immunology, 20(1), 59\u201366.","journal-title":"Seminars in Immunology"},{"issue":"5","key":"4_CR223","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/s41385-021-00419-1","volume":"14","author":"LA van der Kraak","year":"2021","unstructured":"van der Kraak, L. A., et al. (2021). Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFN\u03b3. Mucosal Immunology, 14(5), 1100\u20131112.","journal-title":"Mucosal Immunology"},{"issue":"5","key":"4_CR224","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1053\/j.gastro.2004.07.024","volume":"127","author":"SR Vavricka","year":"2004","unstructured":"Vavricka, S. R., et al. (2004). hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2\/bbe cells. Gastroenterology, 127(5), 1401\u20131409.","journal-title":"Gastroenterology"},{"issue":"11","key":"4_CR225","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ni1131","volume":"5","author":"J Viala","year":"2004","unstructured":"Viala, J., et al. (2004). Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nature Immunology, 5(11), 1166\u20131174.","journal-title":"Nature Immunology"},{"issue":"10","key":"4_CR226","doi-asserted-by":"publisher","first-page":"6808","DOI":"10.4049\/jimmunol.180.10.6808","volume":"180","author":"M Vinzing","year":"2008","unstructured":"Vinzing, M., et al. (2008). NAIP and Ipaf control Legionella pneumophila replication in human cells. Journal of Immunology (Baltimore, Md.: 1950), 180(10), 6808\u20136815.","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"issue":"1","key":"4_CR227","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.immuni.2012.07.006","volume":"37","author":"GI Vladimer","year":"2012","unstructured":"Vladimer, G. I., et al. (2012). The NLRP12 inflammasome recognizes Yersinia pestis. Immunity, 37(1), 96\u2013107.","journal-title":"Immunity"},{"issue":"2","key":"4_CR228","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1574-6976.2007.00094.x","volume":"32","author":"W Vollmer","year":"2008","unstructured":"Vollmer, W., Blanot, D., & Pedro, M. A. (2008). Peptidoglycan structure and architecture. FEMS Microbiology Reviews, 32(2), 149\u2013167.","journal-title":"FEMS Microbiology Reviews"},{"issue":"6","key":"4_CR229","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/intimm\/dxh081","volume":"16","author":"Y Wang","year":"2004","unstructured":"Wang, Y., et al. (2004). PYNOD, a novel Apaf-1\/CED4-like protein is an inhibitor of ASC and caspase-1. International Immunology, 16(6), 777\u2013786.","journal-title":"International Immunology"},{"issue":"6262","key":"4_CR230","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1126\/science.aab3145","volume":"350","author":"P Wang","year":"2015","unstructured":"Wang, P., et al. (2015). Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.), 350(6262), 826\u2013830.","journal-title":"Science (New York, N.Y.)"},{"issue":"5","key":"4_CR231","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1172\/JCI39481","volume":"120","author":"T Watanabe","year":"2010","unstructured":"Watanabe, T., et al. (2010). NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. The Journal of Clinical Investigation, 120(5), 1645\u20131662.","journal-title":"The Journal of Clinical Investigation"},{"key":"4_CR232","doi-asserted-by":"publisher","first-page":"4938473","DOI":"10.1155\/2017\/4938473","volume":"2017","author":"Y Wei","year":"2017","unstructured":"Wei, Y., et al. (2017). NLRP1 overexpression is correlated with the tumorigenesis and proliferation of human breast tumor. BioMed Research International, 2017, 4938473.","journal-title":"BioMed Research International"},{"issue":"5","key":"4_CR233","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","volume":"156","author":"M Wlodarska","year":"2014","unstructured":"Wlodarska, M., et al. (2014). NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell, 156(5), 1045\u20131059.","journal-title":"Cell"},{"issue":"1","key":"4_CR234","doi-asserted-by":"publisher","first-page":"2163839","DOI":"10.1080\/19490976.2022.2163839","volume":"15","author":"MJ Worley","year":"2023","unstructured":"Worley, M. J. (2023). Immune evasion and persistence in enteric bacterial pathogens. Gut Microbes, 15(1), 2163839.","journal-title":"Gut Microbes"},{"issue":"7944","key":"4_CR235","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41586-022-05570-8","volume":"613","author":"L Xiao","year":"2023","unstructured":"Xiao, L., Magupalli, V. G., & Wu, H. (2023). Cryo-EM structures of the active NLRP3 inflammasome disc. Nature, 613(7944), 595\u2013600.","journal-title":"Nature"},{"issue":"2","key":"4_CR236","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.bbrc.2018.04.079","volume":"503","author":"Q Yanling","year":"2018","unstructured":"Yanling, Q., et al. (2018). Inhibition of NLRP9b attenuates acute lung injury through suppressing inflammation, apoptosis and oxidative stress in murine and cell models. Biochemical and Biophysical Research Communications, 503(2), 436\u2013443.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7","key":"4_CR237","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002755","volume":"3","author":"P Zhang","year":"2008","unstructured":"Zhang, P., et al. (2008). Expression analysis of the NLRP gene family suggests a role in human preimplantation development. PLoS One, 3(7), e2755.","journal-title":"PLoS One"},{"key":"4_CR238","doi-asserted-by":"publisher","first-page":"1018504","DOI":"10.3389\/fmicb.2022.1018504","volume":"13","author":"B Zhang","year":"2022","unstructured":"Zhang, B., et al. (2022). Plant NLRs: Evolving with pathogen effectors and engineerable to improve resistance. Frontiers in Microbiology, 13, 1018504.","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"4_CR239","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/imr.12293","volume":"265","author":"Y Zhao","year":"2015","unstructured":"Zhao, Y., & Shao, F. (2015). The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus. Immunological Reviews, 265(1), 85\u2013102.","journal-title":"Immunological Reviews"},{"issue":"7366","key":"4_CR240","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nature10510","volume":"477","author":"Y Zhao","year":"2011","unstructured":"Zhao, Y., et al. (2011). The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature, 477(7366), 596\u2013600.","journal-title":"Nature"},{"issue":"4","key":"4_CR241","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41590-023-01450-z","volume":"24","author":"D Zheng","year":"2023","unstructured":"Zheng, D., et al. (2023). Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation. Nature Immunology, 24(4), 585\u2013594.","journal-title":"Nature Immunology"},{"issue":"7660","key":"4_CR242","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nature22967","volume":"546","author":"S Zhu","year":"2017","unstructured":"Zhu, S., et al. (2017). Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature, 546(7660), 667\u2013670.","journal-title":"Nature"}],"container-title":["Advances in Experimental Medicine and Biology","Innate Immunity: Pattern Recognition and Effector Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-85340-1_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:44:44Z","timestamp":1778496284000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-85340-1_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031853395","9783031853401"],"references-count":242,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-85340-1_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"8 July 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}