{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T09:40:04Z","timestamp":1744882804241,"version":"3.40.4"},"publisher-location":"Cham","reference-count":28,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031869198","type":"print"},{"value":"9783031869204","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-86920-4_13","type":"book-chapter","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:58:09Z","timestamp":1744880289000},"page":"143-152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Early Motor System Degeneration in\u00a0the\u00a0Spinal Cord of\u00a0ALS Patients Using Diffusion MRI: An Exploratory Study"],"prefix":"10.1007","author":[{"given":"Alexandra","family":"Ford","sequence":"first","affiliation":[]},{"given":"Andrew W.","family":"Barritt","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-8264","authenticated-orcid":false,"given":"Samira","family":"Bouyagoub","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"issue":"10","key":"13_CR1","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/ene.14393","volume":"27","author":"P Masrori","year":"2020","unstructured":"Masrori, P., Van Damme, P.: Amyotrophic lateral sclerosis: a clinical review. Eur. J. Neurol. 27(10), 1918\u20131929 (2020)","journal-title":"Eur. J. Neurol."},{"key":"13_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117054","volume":"417","author":"D Richards","year":"2020","unstructured":"Richards, D., Morren, J.A., Pioro, E.P.: Time to diagnosis and factors affecting diagnostic delay in amyotrophic lateral sclerosis. J. Neurol. Sci. 417, 117054 (2020)","journal-title":"J. Neurol. Sci."},{"issue":"9769","key":"13_CR3","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","volume":"377","author":"MC Kiernan","year":"2011","unstructured":"Kiernan, M.C., et al.: Amyotrophic lateral sclerosis. Lancet 377(9769), 942\u201355 (2011)","journal-title":"Lancet"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4103\/2152-7806.169561","volume":"6","author":"S Zarei","year":"2015","unstructured":"Zarei, S., et al.: A comprehensive review of amyotrophic lateral sclerosis. Surg. Neurol. Int. 6, 171 (2015)","journal-title":"Surg. Neurol. Int."},{"issue":"3","key":"13_CR5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","volume":"4","author":"AL Alexander","year":"2007","unstructured":"Alexander, A.L., Lee, J.E., Lazar, M., Field, A.S.: Diffusion tensor imaging of the brain. Neurotherapeutics 4(3), 316\u201329 (2007)","journal-title":"Neurotherapeutics"},{"issue":"4","key":"13_CR6","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","volume":"61","author":"H Zhang","year":"2012","unstructured":"Zhang, H., Schneider, T., Wheeler-Kingshott, C.A., Alexander, D.C.: NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage 61(4), 1000\u201316 (2012)","journal-title":"Neuroimage"},{"issue":"4","key":"13_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095516","volume":"9","author":"MM El Mendili","year":"2014","unstructured":"El Mendili, M.M., et al.: Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis. PLoS ONE 9(4), e95516 (2014)","journal-title":"PLoS ONE"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.neuroimage.2015.01.045","volume":"111","author":"F Grussu","year":"2015","unstructured":"Grussu, F., et al.: Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in vivo. Neuroimage 111, 590\u2013601 (2015)","journal-title":"Neuroimage"},{"issue":"4","key":"13_CR9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/jnnp-2018-318830","volume":"90","author":"RJ Broad","year":"2019","unstructured":"Broad, R.J., et al.: Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS. J. Neurol. Neurosurg. Psychiatry 90(4), 404\u2013411 (2019)","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"5","key":"13_CR10","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/acn3.51035","volume":"7","author":"MC Gabel","year":"2020","unstructured":"Gabel, M.C., et al.: Evolution of white matter damage in amyotrophic lateral sclerosis. Ann. Clin. Transl. Neurol. 7(5), 722\u2013732 (2020)","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"11","key":"13_CR11","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1111\/cns.14270","volume":"29","author":"NX Huang","year":"2023","unstructured":"Huang, N.X., et al.: Corticospinal fibers with different origins impair in amyotrophic lateral sclerosis: a neurite orientation dispersion and density imaging study. CNS Neurosci. Ther. 29(11), 3406\u20133415 (2023)","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"13_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1136\/jnnp.2008.154252","volume":"80","author":"F Agosta","year":"2009","unstructured":"Agosta, F., et al.: A longitudinal diffusion tensor MRI study of the cervical cord and brain in amyotrophic lateral sclerosis patients. J. Neurol. Neurosurg. Psychiatry 80(1), 53\u20135 (2009)","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"11","key":"13_CR13","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1136\/jnnp-2017-317214","volume":"89","author":"G Querin","year":"2018","unstructured":"Querin, G., et al.: Multimodal spinal cord MRI offers accurate diagnostic classification in ALS. J. Neurol. Neurosurg. Psychiatry 89(11), 1220\u20131221 (2018)","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"13","key":"13_CR14","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1177\/1352458519885107","volume":"26","author":"S Collorone","year":"2020","unstructured":"Collorone, S., et al.: Reduced neurite density in the brain and cervical spinal cord in relapsing-remitting multiple sclerosis: a NODDI study. Mult. Scler. 26(13), 1647\u20131657 (2020)","journal-title":"Mult. Scler."},{"key":"13_CR15","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/brain\/awr351","volume":"135","author":"JC Roche","year":"2012","unstructured":"Roche, J.C., et al.: A proposed staging system for amyotrophic lateral sclerosis. Brain 135, 847\u2013852 (2012)","journal-title":"Brain"},{"key":"13_CR16","unstructured":"Gray, H., Standring, S., Ellis, H., Berkovitz, B.K.B.: Gray\u2019s Anatomy: The Anatomical Basis of Clinical Practice. 39th ed., p. 1627. Elsevier Churchill Livingstone, Edinburgh, New York (2005)"},{"issue":"Pt A","key":"13_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuroimage.2016.10.009","volume":"145","author":"B De Leener","year":"2017","unstructured":"De Leener, B., et al.: SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data. Neuroimage 145(Pt A), 24\u201343 (2017)","journal-title":"Neuroimage"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jneumeth.2016.03.001","volume":"264","author":"X Li","year":"2016","unstructured":"Li, X., et al.: The first step for neuroimaging data analysis: DICOM to NIfTI conversion. J. Neurosci. Methods 264, 47\u201356 (2016)","journal-title":"J. Neurosci. Methods"},{"key":"13_CR19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuroimage.2017.10.041","volume":"165","author":"B De Leener","year":"2018","unstructured":"De Leener, B., et al.: PAM50: unbiased multimodal template of the brainstem and spinal cord aligned with the ICBM152 space. Neuroimage 165, 170\u2013179 (2018)","journal-title":"Neuroimage"},{"key":"13_CR20","unstructured":"Bouyagoub, S., Lawden, E., Mamphey, D.F., Cercignani, M., Leigh, P.N., Barritt, A.: Longitudinal Study of Motor System Degeneration in the Brain of ALS Patients Using NODDI. [Manuscript in preparation] (2024)"},{"key":"13_CR21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neuroimage.2015.12.033","volume":"128","author":"C Kodiweera","year":"2016","unstructured":"Kodiweera, C., et al.: Age effects and sex differences in human brain white matter of young to middle-aged adults: a DTI, NODDI, and q-space study. Neuroimage 128, 180\u2013192 (2016)","journal-title":"Neuroimage"},{"issue":"10","key":"13_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224078","volume":"14","author":"M Patzig","year":"2019","unstructured":"Patzig, M., et al.: Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging. PLoS ONE 14(10), e0224078 (2019)","journal-title":"PLoS ONE"},{"key":"13_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116438","volume":"405","author":"XQ Du","year":"2019","unstructured":"Du, X.Q., et al.: Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study. J. Neurol. Sci. 405, 116438 (2019)","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"13_CR24","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1038\/s41598-020-58687-z","volume":"10","author":"T Wimmer","year":"2020","unstructured":"Wimmer, T., et al.: The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI. Sci. Rep. 10(1), 1783 (2020)","journal-title":"Sci. Rep."},{"issue":"3","key":"13_CR25","first-page":"155","volume":"33","author":"RG Gatto","year":"2018","unstructured":"Gatto, R.G., et al.: Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice. Funct. Neurol. 33(3), 155\u2013163 (2018)","journal-title":"Funct. Neurol."},{"issue":"5","key":"13_CR26","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/jnnp.2006.100032","volume":"78","author":"P Valsasina","year":"2007","unstructured":"Valsasina, P., et al.: Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry 78(5), 480\u2013484 (2007)","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"13_CR27","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3109\/17482968.2012.701308","volume":"14","author":"J Cohen-Adad","year":"2013","unstructured":"Cohen-Adad, J., et al.: Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14(1), 30\u201338 (2013)","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"issue":"4","key":"13_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s10334-020-00897-7","volume":"34","author":"S Bouyagoub","year":"2021","unstructured":"Bouyagoub, S., Dowell, N.G., Gabel, M., Cercignani, M.: Comparing multiband and singleband EPI in NODDI at 3 T: what are the implications for reproducibility and study sample sizes? MAGMA 34(4), 499\u2013511 (2021)","journal-title":"MAGMA"}],"container-title":["Lecture Notes in Computer Science","Computational Diffusion MRI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-86920-4_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:58:11Z","timestamp":1744880291000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-86920-4_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031869198","9783031869204"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-86920-4_13","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"18 April 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of Interests"}},{"value":"CDMRI","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Workshop on Computational Diffusion MRI","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Marrakesh","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Morocco","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2024","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"6 October 2024","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"6 October 2024","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"15","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"cdmri2024","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/cmic.cs.ucl.ac.uk\/cdmri\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}