{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:45:24Z","timestamp":1787168724412,"version":"build-2736575974"},"publisher-location":"Cham","reference-count":135,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031883606","type":"print"},{"value":"9783031883613","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-88361-3_23","type":"book-chapter","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:42:27Z","timestamp":1756478547000},"page":"545-571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Skeletal Muscle and the Immune System"],"prefix":"10.1007","author":[{"given":"Brandt D.","family":"Pence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"23_CR1","doi-asserted-by":"publisher","first-page":"E289","DOI":"10.1152\/AJPENDO.00009.2023","volume":"324","author":"AM Abdelmoez","year":"2023","unstructured":"Abdelmoez AM, Dmytriyeva O et al (2023) Cell selectivity in succinate receptor SUCNR1\/GPR91 signaling in skeletal muscle. Am J Physiol Endocrinol Metab 324:E289\u2013E298. https:\/\/doi.org\/10.1152\/AJPENDO.00009.2023","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"23_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/J.0954-6820.1970.TB02938.X","volume":"187","author":"B Ahlborg","year":"1970","unstructured":"Ahlborg B, Ahlborg G (1970) Exercise leukocytosis with and without beta-adrenergic blockade. Acta Med Scand 187:241\u2013246. https:\/\/doi.org\/10.1111\/J.0954-6820.1970.TB02938.X","journal-title":"Acta Med Scand"},{"key":"23_CR3","doi-asserted-by":"publisher","first-page":"1122586","DOI":"10.3389\/FIMMU.2023.1122586\/BIBTEX","volume":"14","author":"CLC Almeida-da-Silva","year":"2023","unstructured":"Almeida-da-Silva CLC, Savio LEB, Coutinho-Silva R, Ojcius DM (2023) The role of NOD-like receptors in innate immunity. Front Immunol 14:1122586. https:\/\/doi.org\/10.3389\/FIMMU.2023.1122586\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR4","doi-asserted-by":"publisher","unstructured":"Arinda BN, Innabi YA, Grasis JA, Oviedo NJ (2022) Non-traditional roles of immune cells in regeneration: an evolutionary perspective. Development 149. https:\/\/doi.org\/10.1242\/DEV.199903","DOI":"10.1242\/DEV.199903"},{"key":"23_CR5","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/JEM.20070075","volume":"204","author":"L Arnold","year":"2007","unstructured":"Arnold L, Henry A et al (2007) Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204:1057\u20131069. https:\/\/doi.org\/10.1084\/JEM.20070075","journal-title":"J Exp Med"},{"key":"23_CR6","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.2209976119\/SUPPL_FILE\/PNAS.2209976119.SAPP.PDF","volume":"119","author":"F Babaeijandaghi","year":"2022","unstructured":"Babaeijandaghi F, Paiero A et al (2022) TNF\u03b1 and IFN\u03b3 cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration. Proc Natl Acad Sci USA 119:e2209976119. https:\/\/doi.org\/10.1073\/PNAS.2209976119\/SUPPL_FILE\/PNAS.2209976119.SAPP.PDF","journal-title":"Proc Natl Acad Sci USA"},{"key":"23_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/S13238-012-2104-8","volume":"4","author":"M Bao","year":"2013","unstructured":"Bao M, Liu YJ (2013) Regulation of TLR7\/9 signaling in plasmacytoid dendritic cells. Protein Cell 4:40\u201352. https:\/\/doi.org\/10.1007\/S13238-012-2104-8","journal-title":"Protein Cell"},{"key":"23_CR8","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/ART.27183","volume":"62","author":"M Brigitte","year":"2010","unstructured":"Brigitte M, Schilte C et al (2010) Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury. Arthritis Rheum 62:268\u2013279. https:\/\/doi.org\/10.1002\/ART.27183","journal-title":"Arthritis Rheum"},{"key":"23_CR9","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/J.IMMUNI.2021.06.006","volume":"54","author":"GL Burn","year":"2021","unstructured":"Burn GL, Foti A, Marsman G, Patel DF, Zychlinsky A (2021) The neutrophil. Immunity 54:1377\u20131391. https:\/\/doi.org\/10.1016\/J.IMMUNI.2021.06.006","journal-title":"Immunity"},{"key":"23_CR10","doi-asserted-by":"publisher","unstructured":"Burzyn D, Kuswanto W et al (2013) A special population of regulatory T cells potentiates muscle repair. Cell 155. https:\/\/doi.org\/10.1016\/J.CELL.2013.10.054","DOI":"10.1016\/J.CELL.2013.10.054"},{"key":"23_CR11","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3389\/FIMMU.2018.00648","volume":"9","author":"JP Campbell","year":"2018","unstructured":"Campbell JP, Turner JE (2018) Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan. Front Immunol 9:648. https:\/\/doi.org\/10.3389\/FIMMU.2018.00648","journal-title":"Front Immunol"},{"key":"23_CR12","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.4049\/JIMMUNOL.1501339","volume":"196","author":"Y Cao","year":"2016","unstructured":"Cao Y, Amezquita RA et al (2016) Autoreactive T cells from patients with myasthenia gravis are characterized by elevated IL-17, IFN-\u03b3, and GM-CSF and diminished IL-10 production. J Immunol 196:2075\u20132084. https:\/\/doi.org\/10.4049\/JIMMUNOL.1501339","journal-title":"J Immunol"},{"key":"23_CR13","doi-asserted-by":"publisher","first-page":"1177721","DOI":"10.3389\/FIMMU.2023.1177721\/BIBTEX","volume":"14","author":"PO Carstens","year":"2023","unstructured":"Carstens PO, M\u00fcllar LM et al (2023) Skeletal muscle fibers produce B-cell stimulatory factors in chronic myositis. Front Immunol 14:1177721. https:\/\/doi.org\/10.3389\/FIMMU.2023.1177721\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR14","doi-asserted-by":"publisher","unstructured":"Castiglioni A, Corna G et al (2015) FOXP3+ T cells recruited to sites of sterile skeletal muscle injury regulate the fate of satellite cells and guide effective tissue regeneration. PLoS One 10. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0128094","DOI":"10.1371\/JOURNAL.PONE.0128094"},{"key":"23_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/IMM.13152","volume":"160","author":"ES Chambers","year":"2020","unstructured":"Chambers ES, Vukmanovic-Stejic M (2020) Skin barrier immunity and ageing. Immunology 160:116\u2013125. https:\/\/doi.org\/10.1111\/IMM.13152","journal-title":"Immunology"},{"key":"23_CR16","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/J.JACI.2009.12.980","volume":"125","author":"DD Chaplin","year":"2010","unstructured":"Chaplin DD (2010) Overview of the immune response. J Allergy Clin Immunol 125:S3. https:\/\/doi.org\/10.1016\/J.JACI.2009.12.980","journal-title":"J Allergy Clin Immunol"},{"key":"23_CR17","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/ONCOTARGET.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H et al (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9:7204. https:\/\/doi.org\/10.18632\/ONCOTARGET.23208","journal-title":"Oncotarget"},{"key":"23_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/ANTIB8040055","volume":"8","author":"ML Chiu","year":"2019","unstructured":"Chiu ML, Goulet DR, Teplyakov A, Gilliland GL (2019) Antibody structure and function: the basis for engineering therapeutics. Antibodies 8:55. https:\/\/doi.org\/10.3390\/ANTIB8040055","journal-title":"Antibodies"},{"key":"23_CR19","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1194\/JLR.M500294-JLR200","volume":"46","author":"S Cinti","year":"2005","unstructured":"Cinti S, Mitchell G et al (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347\u20132355. https:\/\/doi.org\/10.1194\/JLR.M500294-JLR200","journal-title":"J Lipid Res"},{"key":"23_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2014.00472\/BIBTEX","volume":"5","author":"EA Clark","year":"2014","unstructured":"Clark EA (2014) A short history of the B-cell-associated surface molecule CD40. Front Immunol 5:113267. https:\/\/doi.org\/10.3389\/FIMMU.2014.00472\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR21","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/J.JACI.2017.09.005","volume":"140","author":"AA Cruz","year":"2017","unstructured":"Cruz AA, Cooper PJ, Figueiredo CA, Alcantara-Neves NM, Rodrigues LC, Barreto ML (2017) Global issues in allergy and immunology: parasitic infections and allergy. J Allergy Clin Immunol 140:1217\u20131228. https:\/\/doi.org\/10.1016\/J.JACI.2017.09.005","journal-title":"J Allergy Clin Immunol"},{"key":"23_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.18632\/AGING.102740","volume":"12","author":"CY Cui","year":"2020","unstructured":"Cui CY, Ferrucci L (2020) Macrophages in skeletal muscle aging. Aging (Albany NY) 12:3. https:\/\/doi.org\/10.18632\/AGING.102740","journal-title":"Aging (Albany NY)"},{"key":"23_CR23","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/J.CELL.2019.03.016","volume":"177","author":"JG Cyster","year":"2019","unstructured":"Cyster JG, Allen CDC (2019) B cell responses: cell interaction dynamics and decisions. Cell 177:524\u2013540. https:\/\/doi.org\/10.1016\/J.CELL.2019.03.016","journal-title":"Cell"},{"key":"23_CR24","doi-asserted-by":"publisher","unstructured":"Deguine J, Barton GM (2014) MyD88: a central player in innate immune signaling. F1000Prime Rep 6. https:\/\/doi.org\/10.12703\/P6-97","DOI":"10.12703\/P6-97"},{"key":"23_CR25","doi-asserted-by":"publisher","first-page":"R1189","DOI":"10.1016\/J.CUB.2020.08.028","volume":"30","author":"T Dimitriu","year":"2020","unstructured":"Dimitriu T, Szczelkun MD, Westra ER (2020) Evolutionary ecology and interplay of prokaryotic innate and adaptive immune systems. Curr Biol 30:R1189\u2013R1202. https:\/\/doi.org\/10.1016\/J.CUB.2020.08.028","journal-title":"Curr Biol"},{"key":"23_CR26","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1002\/EJI.200737772","volume":"37","author":"CA Dinarello","year":"2007","unstructured":"Dinarello CA (2007) Historical review of cytokines. Eur J Immunol 37:S34. https:\/\/doi.org\/10.1002\/EJI.200737772","journal-title":"Eur J Immunol"},{"key":"23_CR27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3109\/00365513.2015.1052550","volume":"75","author":"M Djaldetti","year":"2015","unstructured":"Djaldetti M, Bessler H (2015) High temperature affects the phagocytic activity of human peripheral blood mononuclear cells. Scand J Clin Lab Invest 75:482\u2013486. https:\/\/doi.org\/10.3109\/00365513.2015.1052550","journal-title":"Scand J Clin Lab Invest"},{"key":"23_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","volume":"204","author":"AC Doran","year":"2019","unstructured":"Doran AC, Yurdagul A, Tabas I (2019) Efferocytosis in health and disease. Nat Rev Immunol 204:254\u2013267. https:\/\/doi.org\/10.1038\/s41577-019-0240-6","journal-title":"Nat Rev Immunol"},{"key":"23_CR29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/NRI3843","volume":"15","author":"SS Evans","year":"2015","unstructured":"Evans SS, Repasky EA, Fisher DT (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol 15:335. https:\/\/doi.org\/10.1038\/NRI3843","journal-title":"Nat Rev Immunol"},{"key":"23_CR30","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1152\/JAPPLPHYSIOL.00566.2004","volume":"98","author":"AS Fairey","year":"2005","unstructured":"Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR (2005) Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. J Appl Physiol 98:1534\u20131540. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00566.2004","journal-title":"J Appl Physiol"},{"key":"23_CR31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/nri.2016.13","volume":"16","author":"DL Farber","year":"2016","unstructured":"Farber DL, Netea MG, Radbruch A, Rajewsky K, Zinkernagel RM (2016) Immunological memory: lessons from the past and a look to the future. Nat Rev Immunol 16:124\u2013128. https:\/\/doi.org\/10.1038\/nri.2016.13","journal-title":"Nat Rev Immunol"},{"key":"23_CR32","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/J.CELL.2020.02.041","volume":"180","author":"KA Fitzgerald","year":"2020","unstructured":"Fitzgerald KA, Kagan JC (2020) Toll-like receptors and the control of immunity. Cell 180:1044. https:\/\/doi.org\/10.1016\/J.CELL.2020.02.041","journal-title":"Cell"},{"key":"23_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri2569","volume":"9","author":"TBH Geijtenbeek","year":"2009","unstructured":"Geijtenbeek TBH, Gringhuis SI (2009) Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 9:465\u2013479. https:\/\/doi.org\/10.1038\/nri2569","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"23_CR34","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.1841","volume":"11","author":"DI Godfrey","year":"2010","unstructured":"Godfrey DI, Stankovic S, Baxter AG (2010) Raising the NKT cell family. Nat Immunol 11(3):197\u2013206. https:\/\/doi.org\/10.1038\/ni.1841","journal-title":"Nat Immunol"},{"issue":"7540","key":"23_CR35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","volume":"518","author":"E Gomez Perdiguero","year":"2014","unstructured":"Gomez Perdiguero E, Klapproth K et al (2014) Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518(7540):547\u2013551. https:\/\/doi.org\/10.1038\/nature13989","journal-title":"Nature"},{"key":"23_CR36","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1590\/ABD1806-4841.20164741","volume":"91","author":"ACDO Gonzalez","year":"2016","unstructured":"Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP (2016) Wound healing\u2014a literature review. An Bras Dermatol 91:614. https:\/\/doi.org\/10.1590\/ABD1806-4841.20164741","journal-title":"An Bras Dermatol"},{"key":"23_CR37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/J.IMMUNI.2016.02.026","volume":"44","author":"S Gordon","year":"2016","unstructured":"Gordon S (2016) Phagocytosis: an immunobiologic process. Immunity 44:463\u2013475. https:\/\/doi.org\/10.1016\/J.IMMUNI.2016.02.026","journal-title":"Immunity"},{"issue":"1","key":"23_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-023-38624-0","volume":"14","author":"FA Graca","year":"2023","unstructured":"Graca FA, Stephan A et al (2023) Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles. Nat Commun 14(1):1\u201320. https:\/\/doi.org\/10.1038\/s41467-023-38624-0","journal-title":"Nat Commun"},{"key":"23_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/MUS.20649","volume":"35","author":"SA Greenberg","year":"2007","unstructured":"Greenberg SA, Pinkus GS, Amato AA, Pinkus JL (2007) Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve 35:17\u201323. https:\/\/doi.org\/10.1002\/MUS.20649","journal-title":"Muscle Nerve"},{"key":"23_CR40","doi-asserted-by":"publisher","unstructured":"Grover P, Goel PN, Greene MI (2021) Regulatory T cells: regulation of identity and function. Front Immunol 12. https:\/\/doi.org\/10.3389\/FIMMU.2021.750542","DOI":"10.3389\/FIMMU.2021.750542"},{"key":"23_CR41","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/COH.0B013E328335C2F6","volume":"5","author":"L Guglani","year":"2010","unstructured":"Guglani L, Khader SA (2010) Th17 cytokines in mucosal immunity and inflammation. Curr Opin HIV AIDS 5:120. https:\/\/doi.org\/10.1097\/COH.0B013E328335C2F6","journal-title":"Curr Opin HIV AIDS"},{"key":"23_CR42","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","volume":"49","author":"M Guilliams","year":"2018","unstructured":"Guilliams M, Mildner A, Yona S (2018) Developmental and functional heterogeneity of monocytes. Immunity 49:595\u2013613","journal-title":"Immunity"},{"key":"23_CR43","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/EJI.201646547","volume":"48","author":"C Gutzeit","year":"2018","unstructured":"Gutzeit C, Chen K, Cerutti A (2018) The enigmatic function of IgD: some answers at last. Eur J Immunol 48:1101. https:\/\/doi.org\/10.1002\/EJI.201646547","journal-title":"Eur J Immunol"},{"key":"23_CR44","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/J.IT.2017.04.002","volume":"38","author":"S Halle","year":"2017","unstructured":"Halle S, Halle O, F\u00f6rster R (2017) Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo. Trends Immunol 38:432\u2013443. https:\/\/doi.org\/10.1016\/J.IT.2017.04.002","journal-title":"Trends Immunol"},{"key":"23_CR45","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1146\/ANNUREV-IMMUNOL-102119-074236","volume":"39","author":"TW Hand","year":"2021","unstructured":"Hand TW, Reboldi A (2021) Production and function of immunoglobulin A. Annu Rev Immunol 39:695\u2013718. https:\/\/doi.org\/10.1146\/ANNUREV-IMMUNOL-102119-074236","journal-title":"Annu Rev Immunol"},{"key":"23_CR46","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/FEBS.14466","volume":"285","author":"CE Hughes","year":"2018","unstructured":"Hughes CE, Nibbs RJB (2018) A guide to chemokines and their receptors. FEBS J 285:2944. https:\/\/doi.org\/10.1111\/FEBS.14466","journal-title":"FEBS J"},{"issue":"1","key":"23_CR47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41577-023-00897-3","volume":"24","author":"T Inoue","year":"2024","unstructured":"Inoue T, Kurosaki T (2024) Memory B cells. Nat Rev Immunol 24(1):5\u201317. https:\/\/doi.org\/10.1038\/s41577-023-00897-3","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"23_CR48","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","volume":"18","author":"LB Ivashkiv","year":"2018","unstructured":"Ivashkiv LB (2018) IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy. Nat Rev Immunol 18(9):545\u2013558. https:\/\/doi.org\/10.1038\/s41577-018-0029-z","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"23_CR49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","volume":"12","author":"GD Kalliolias","year":"2015","unstructured":"Kalliolias GD, Ivashkiv LB (2015) TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol 12(1):49\u201362. https:\/\/doi.org\/10.1038\/nrrheum.2015.169","journal-title":"Nat Rev Rheumatol"},{"key":"23_CR50","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/IJABMR.IJABMR_63_17","volume":"7","author":"M Kaur","year":"2017","unstructured":"Kaur M (2017) C-reactive protein: a prognostic indicator. Int J Appl Basic Med Res 7:83. https:\/\/doi.org\/10.4103\/IJABMR.IJABMR_63_17","journal-title":"Int J Appl Basic Med Res"},{"key":"23_CR51","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1089\/VIM.2019.0184\/ASSET\/IMAGES\/LARGE\/VIM.2019.0184_FIGURE6.JPEG","volume":"33","author":"K Kedzierska","year":"2020","unstructured":"Kedzierska K, Koutsakos M (2020) The ABC of major histocompatibility complexes and T cell receptors in health and disease. Viral Immunol 33:160\u2013178. https:\/\/doi.org\/10.1089\/VIM.2019.0184\/ASSET\/IMAGES\/LARGE\/VIM.2019.0184_FIGURE6.JPEG","journal-title":"Viral Immunol"},{"issue":"5","key":"23_CR52","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41590-019-0372-7","volume":"20","author":"N Keiran","year":"2019","unstructured":"Keiran N, Ceperuelo-Mallafr\u00e9 V, Calvo E, Hern\u00e1ndez-Alvarez MI, Ejarque M, N\u00fa\u00f1ez-Roa C, Horrillo D, Maym\u00f3-Masip E, Rodr\u00edguez MM, Fradera R, de la Rosa JV, Jorba R, Megia A, Zorzano A, Medina-G\u00f3mez G, Serena C, Castrillo A, Vendrell J, Fern\u00e1ndez-Veledo S (2019) SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat Immunol 20(5):581\u2013592. https:\/\/doi.org\/10.1038\/s41590-019-0372-7","journal-title":"Nat Immunol"},{"key":"23_CR53","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/cr.2015.68","volume":"25","author":"B Kelly","year":"2015","unstructured":"Kelly B, O\u2019Neill LA (2015) Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res 25:771\u2013784. https:\/\/doi.org\/10.1038\/cr.2015.68","journal-title":"Cell Res"},{"key":"23_CR54","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/NRI3667","volume":"14","author":"L Klein","year":"2014","unstructured":"Klein L, Kyewski B, Allen PM, Hogquist KA (2014) Positive and negative selection of the T cell repertoire: what thymocytes see and don\u2019t see. Nat Rev Immunol 14:377. https:\/\/doi.org\/10.1038\/NRI3667","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"23_CR55","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1038\/s12276-023-01105-x","volume":"55","author":"CH Koh","year":"2023","unstructured":"Koh CH, Lee S, Kwak M, Kim BS, Chung Y (2023) CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential. Exp Mol Med 55(11):2287\u20132299. https:\/\/doi.org\/10.1038\/s12276-023-01105-x","journal-title":"Exp Mol Med"},{"key":"23_CR56","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/J.IMMUNI.2018.01.007","volume":"48","author":"BV Kumar","year":"2018","unstructured":"Kumar BV, Connors TJ, Farber DL (2018) Human T cell development, localization, and function throughout life. Immunity 48:202. https:\/\/doi.org\/10.1016\/J.IMMUNI.2018.01.007","journal-title":"Immunity"},{"key":"23_CR57","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/J.CCELL.2022.05.006","volume":"40","author":"E Kurz","year":"2022","unstructured":"Kurz E, Hirsch CA et al (2022) Exercise-induced engagement of the IL-15\/IL-15R\u03b1 axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell 40:720\u2013737.e5. https:\/\/doi.org\/10.1016\/J.CCELL.2022.05.006","journal-title":"Cancer Cell"},{"issue":"5","key":"23_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-018-0426-z","volume":"9","author":"L Ladislau","year":"2018","unstructured":"Ladislau L, Portilho DM et al (2018) Activated dendritic cells modulate proliferation and differentiation of human myoblasts. Cell Death Dis 9(5):1\u201314. https:\/\/doi.org\/10.1038\/s41419-018-0426-z","journal-title":"Cell Death Dis"},{"key":"23_CR59","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1007\/S00018-016-2268-0","volume":"73","author":"NX Land\u00e9n","year":"2016","unstructured":"Land\u00e9n NX, Li D, St\u00e5hle M (2016) Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci 73:3861. https:\/\/doi.org\/10.1007\/S00018-016-2268-0","journal-title":"Cell Mol Life Sci"},{"key":"23_CR60","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","volume":"86","author":"B Lemaitre","year":"1996","unstructured":"Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette sp\u00e4tzle\/toll\/cactus controls the potent antifungal response in drosophila adults. Cell 86:973\u2013983. https:\/\/doi.org\/10.1016\/S0092-8674(00)80172-5","journal-title":"Cell"},{"issue":"1","key":"23_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01151-3","volume":"7","author":"X Li","year":"2022","unstructured":"Li X, Yang Y, Zhang B et al (2022) Lactate metabolism in human health and disease. Signal Transduct Target Ther 7(1):1\u201322. https:\/\/doi.org\/10.1038\/s41392-022-01151-3","journal-title":"Signal Transduct Target Ther"},{"key":"23_CR62","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/NRI2807","volume":"10","author":"GW Litman","year":"2010","unstructured":"Litman GW, Rast JP, Fugmann SD (2010) The origins of vertebrate adaptive immunity. Nat Rev Immunol 10:543. https:\/\/doi.org\/10.1038\/NRI2807","journal-title":"Nat Rev Immunol"},{"key":"23_CR63","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1084\/JEM.20160061","volume":"213","author":"A Littlewood-Evans","year":"2016","unstructured":"Littlewood-Evans A, Sarret S et al (2016) GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. J Exp Med 213:1655\u20131662. https:\/\/doi.org\/10.1084\/JEM.20160061","journal-title":"J Exp Med"},{"key":"23_CR64","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1097\/BOR.0B013E3283157538","volume":"20","author":"CM L\u00f3pez De Padilla","year":"2008","unstructured":"L\u00f3pez De Padilla CM, Reed AM (2008) Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. Curr Opin Rheumatol 20:669\u2013674. https:\/\/doi.org\/10.1097\/BOR.0B013E3283157538","journal-title":"Curr Opin Rheumatol"},{"key":"23_CR65","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1002\/ART.22558","volume":"56","author":"CM L\u00f3pez De Padilla","year":"2007","unstructured":"L\u00f3pez De Padilla CM, Vallejo AN et al (2007) Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. Arthritis Rheum 56:1658\u20131668. https:\/\/doi.org\/10.1002\/ART.22558","journal-title":"Arthritis Rheum"},{"key":"23_CR66","doi-asserted-by":"publisher","unstructured":"Lu Q, Ceddia MA, Price EA, Ye SM, Woods JA (1999) Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice. Am J Phys 276. https:\/\/doi.org\/10.1152\/AJPREGU.1999.276.2.R482","DOI":"10.1152\/AJPREGU.1999.276.2.R482"},{"key":"23_CR67","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1155\/2012\/925135","volume":"2012","author":"RV Luckheeram","year":"2012","unstructured":"Luckheeram RV, Zhou R, Verma AD, Xia B (2012) CD4+T cells: differentiation and functions. Clin Dev Immunol 2012:12. https:\/\/doi.org\/10.1155\/2012\/925135","journal-title":"Clin Dev Immunol"},{"key":"23_CR68","doi-asserted-by":"publisher","unstructured":"Manoharan I, Prasad PD, Thangaraju M, Manicassamy S (2021) Lactate-dependent regulation of immune responses by dendritic cells and macrophages. Front Immunol 12. https:\/\/doi.org\/10.3389\/FIMMU.2021.691134","DOI":"10.3389\/FIMMU.2021.691134"},{"key":"23_CR69","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1056\/NEJMRA2206346\/SUPPL_FILE\/NEJMRA2206346_DISCLOSURES.PDF","volume":"388","author":"A Mantovani","year":"2023","unstructured":"Mantovani A, Garlanda C (2023) Humoral innate immunity and acute-phase proteins. N Engl J Med 388:439\u2013452. https:\/\/doi.org\/10.1056\/NEJMRA2206346\/SUPPL_FILE\/NEJMRA2206346_DISCLOSURES.PDF","journal-title":"N Engl J Med"},{"issue":"9","key":"23_CR70","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/s41577-023-00848-y","volume":"23","author":"E Mass","year":"2023","unstructured":"Mass E, Nimmerjahn F, Kierdorf K, Schlitzer A (2023) Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol 23(9):563\u2013579. https:\/\/doi.org\/10.1038\/s41577-023-00848-y","journal-title":"Nat Rev Immunol"},{"key":"23_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PBIO.1001397","volume":"10","author":"JR McGhee","year":"2012","unstructured":"McGhee JR, Fujihashi K (2012) Inside the mucosal immune system. PLoS Biol 10:e1001397. https:\/\/doi.org\/10.1371\/JOURNAL.PBIO.1001397","journal-title":"PLoS Biol"},{"key":"23_CR72","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/J.CELL.2010.03.006","volume":"140","author":"R Medzhitov","year":"2010","unstructured":"Medzhitov R (2010) Inflammation 2010: new adventures of an old flame. Cell 140:771\u2013776. https:\/\/doi.org\/10.1016\/J.CELL.2010.03.006","journal-title":"Cell"},{"issue":"3","key":"23_CR73","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41423-020-00541-3","volume":"18","author":"DM Mosser","year":"2020","unstructured":"Mosser DM, Hamidzadeh K, Goncalves R (2020) Macrophages and the maintenance of homeostasis. Cell Mol Immunol 18(3):579\u2013587. https:\/\/doi.org\/10.1038\/s41423-020-00541-3","journal-title":"Cell Mol Immunol"},{"key":"23_CR74","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/ANNUREV-IMMUNOL-101819-074948","volume":"39","author":"AM Mujal","year":"2021","unstructured":"Mujal AM, Delconte RB, Sun JC (2021) Natural killer cells: from innate to adaptive features. Annu Rev Immunol 39:417\u2013447. https:\/\/doi.org\/10.1146\/ANNUREV-IMMUNOL-101819-074948","journal-title":"Annu Rev Immunol"},{"key":"23_CR75","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","volume":"79","author":"PJ Murray","year":"2017","unstructured":"Murray PJ (2017) Macrophage polarization. Annu Rev Physiol 79:541\u2013566. https:\/\/doi.org\/10.1146\/annurev-physiol-022516-034339","journal-title":"Annu Rev Physiol"},{"key":"23_CR76","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1210\/JC.2007-2561","volume":"93","author":"AR Nielsen","year":"2008","unstructured":"Nielsen AR, Hojman P et al (2008) Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J Clin Endocrinol Metab 93:4486\u20134493. https:\/\/doi.org\/10.1210\/JC.2007-2561","journal-title":"J Clin Endocrinol Metab"},{"key":"23_CR77","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1113\/JPHYSIOL.2007.139618","volume":"584","author":"AR Nielsen","year":"2007","unstructured":"Nielsen AR, Mounier R et al (2007) Expression of interleukin-15 in human skeletal muscle\u2014effect of exercise and muscle fibre type composition. J Physiol 584:305. https:\/\/doi.org\/10.1113\/JPHYSIOL.2007.139618","journal-title":"J Physiol"},{"key":"23_CR78","doi-asserted-by":"publisher","unstructured":"Nieman DC (1994) Exercise, infection, and immunity. Int J Sports Med 15(Suppl 3). https:\/\/doi.org\/10.1055\/S-2007-1021128","DOI":"10.1055\/S-2007-1021128"},{"key":"23_CR79","first-page":"316","volume":"30","author":"DC Nieman","year":"1990","unstructured":"Nieman DC, Johanssen LM, Lee JW, Arabatzis K (1990) Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 30:316\u2013328","journal-title":"J Sports Med Phys Fitness"},{"key":"23_CR80","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","volume":"16","author":"LAJ O\u2019Neill","year":"2016","unstructured":"O\u2019Neill LAJ, Kishton RJ, Rathmell J (2016) A guide to immunometabolism for immunologists. Nat Rev Immunol 16:553\u2013565. https:\/\/doi.org\/10.1038\/nri.2016.70","journal-title":"Nat Rev Immunol"},{"issue":"Pt 3","key":"23_CR81","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/J.1469-7793.1998.949BP.X","volume":"508","author":"K Ostrowski","year":"1998","unstructured":"Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK (1998) Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 508(Pt 3):949\u2013953. https:\/\/doi.org\/10.1111\/J.1469-7793.1998.949BP.X","journal-title":"J Physiol"},{"key":"23_CR82","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/ART.11428","volume":"50","author":"G Page","year":"2004","unstructured":"Page G, Chevrel G, Miossec P (2004) Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: interaction with chemokines and Th1 cytokine-producing cells. Arthritis Rheum 50:199\u2013208. https:\/\/doi.org\/10.1002\/ART.11428","journal-title":"Arthritis Rheum"},{"key":"23_CR83","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/J.CYTOGFR.2014.11.003","volume":"26","author":"R Paolini","year":"2015","unstructured":"Paolini R, Bernardini G, Molfetta R, Santoni A (2015) NK cells and interferons. Cytokine Growth Factor Rev 26:113\u2013120. https:\/\/doi.org\/10.1016\/J.CYTOGFR.2014.11.003","journal-title":"Cytokine Growth Factor Rev"},{"key":"23_CR84","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1016\/J.CELL.2022.10.007","volume":"185","author":"MD Park","year":"2022","unstructured":"Park MD, Silvin A, Ginhoux F, Merad M (2022) Macrophages in health and disease. Cell 185:4259\u20134279. https:\/\/doi.org\/10.1016\/J.CELL.2022.10.007","journal-title":"Cell"},{"key":"23_CR85","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2018.03176\/BIBTEX","volume":"10","author":"TA Patente","year":"2019","unstructured":"Patente TA, Pinho MP et al (2019) Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy. Front Immunol 10:422571. https:\/\/doi.org\/10.3389\/FIMMU.2018.03176\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR86","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/J.MICINF.2011.10.006","volume":"14","author":"PY Perera","year":"2012","unstructured":"Perera PY, Lichy JH, Waldmann TA, Perera LP (2012) The role of Interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect 14:247. https:\/\/doi.org\/10.1016\/J.MICINF.2011.10.006","journal-title":"Microbes Infect"},{"key":"23_CR87","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1152\/JAPPLPHYSIOL.00164.2004\/ASSET\/IMAGES\/LARGE\/ZDG0040537181003.JPEG","volume":"98","author":"AMW Petersen","year":"2005","unstructured":"Petersen AMW, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98:1154\u20131162. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00164.2004\/ASSET\/IMAGES\/LARGE\/ZDG0040537181003.JPEG","journal-title":"J Appl Physiol"},{"key":"23_CR88","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1152\/AJPENDO.00553.2012\/ASSET\/IMAGES\/LARGE\/ZH10051367670001.JPEG","volume":"304","author":"NJ Pillon","year":"2013","unstructured":"Pillon NJ, Bilan PJ, Fink LN, Klip A (2013) Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab 304:453\u2013465. https:\/\/doi.org\/10.1152\/AJPENDO.00553.2012\/ASSET\/IMAGES\/LARGE\/ZH10051367670001.JPEG","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"23_CR89","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","volume":"22","author":"N Pishesha","year":"2022","unstructured":"Pishesha N, Harmand TJ, Ploegh HL (2022) A guide to antigen processing and presentation. Nat Rev Immunol 22(12):751\u2013764. https:\/\/doi.org\/10.1038\/s41577-022-00707-2","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"23_CR90","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","volume":"21","author":"AJ Pollard","year":"2020","unstructured":"Pollard AJ, Bijker EM (2020) A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol 21(2):83\u2013100. https:\/\/doi.org\/10.1038\/s41577-020-00479-7","journal-title":"Nat Rev Immunol"},{"key":"23_CR91","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/SCIENCE.282.5396.2085","volume":"282","author":"A Poltorak","year":"1998","unstructured":"Poltorak A, He X et al (1998) Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene. Science 282:2085\u20132088. https:\/\/doi.org\/10.1126\/SCIENCE.282.5396.2085","journal-title":"Science"},{"key":"23_CR92","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/CPHY.C100054","volume":"1","author":"SK Powers","year":"2011","unstructured":"Powers SK, Ji LL, Kavazis AN, Jackson MJ (2011) Reactive oxygen species: impact on skeletal muscle. Compr Physiol 1:941. https:\/\/doi.org\/10.1002\/CPHY.C100054","journal-title":"Compr Physiol"},{"key":"23_CR93","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/JLB.MR0718-269R","volume":"105","author":"I Prager","year":"2019","unstructured":"Prager I, Watzl C (2019) Mechanisms of natural killer cell-mediated cellular cytotoxicity. J Leukoc Biol 105:1319\u20131329. https:\/\/doi.org\/10.1002\/JLB.MR0718-269R","journal-title":"J Leukoc Biol"},{"key":"23_CR94","doi-asserted-by":"publisher","first-page":"2249977","DOI":"10.1002\/EJI.202249977","volume":"53","author":"D Radtke","year":"2023","unstructured":"Radtke D, Voehringer D (2023) Granulocyte development, tissue recruitment, and function during allergic inflammation. Eur J Immunol 53:2249977. https:\/\/doi.org\/10.1002\/EJI.202249977","journal-title":"Eur J Immunol"},{"key":"23_CR95","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/J.CELL.2020.08.039","volume":"183","author":"A Reddy","year":"2020","unstructured":"Reddy A, Bozi LHM et al (2020) pH-gated succinate secretion regulates muscle remodeling in response to exercise. Cell 183:62\u201375.e17. https:\/\/doi.org\/10.1016\/J.CELL.2020.08.039","journal-title":"Cell"},{"key":"23_CR96","doi-asserted-by":"publisher","first-page":"1729683","DOI":"10.1080\/19420862.2020.1729683","volume":"12","author":"AR Rees","year":"2020","unstructured":"Rees AR (2020) Understanding the human antibody repertoire. MAbs 12:1729683. https:\/\/doi.org\/10.1080\/19420862.2020.1729683","journal-title":"MAbs"},{"issue":"9","key":"23_CR97","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","volume":"20","author":"J Rehwinkel","year":"2020","unstructured":"Rehwinkel J, Gack MU (2020) RIG-I-like receptors: their regulation and roles in RNA sensing. Nat Rev Immunol 20(9):537\u2013551. https:\/\/doi.org\/10.1038\/s41577-020-0288-3","journal-title":"Nat Rev Immunol"},{"key":"23_CR98","doi-asserted-by":"publisher","unstructured":"Rigamonti E, Zordan P, Sciorati C, Rovere-Querini P, Brunelli S (2014) Macrophage plasticity in skeletal muscle repair. Biomed Res Int. https:\/\/doi.org\/10.1155\/2014\/560629","DOI":"10.1155\/2014\/560629"},{"key":"23_CR99","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/NI.1657","volume":"9","author":"T Rubic","year":"2008","unstructured":"Rubic T, Lametschwandtner GJ et al (2008) Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol 9:1261\u20131269. https:\/\/doi.org\/10.1038\/NI.1657","journal-title":"Nat Immunol"},{"key":"23_CR100","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/S40279-020-01402-9\/FIGURES\/5","volume":"51","author":"C Rumpf","year":"2021","unstructured":"Rumpf C, Proschinger S et al (2021) The effect of acute physical exercise on NK-cell Cytolytic activity: a systematic review and meta-analysis. Sport Med 51:519\u2013530. https:\/\/doi.org\/10.1007\/S40279-020-01402-9\/FIGURES\/5","journal-title":"Sport Med"},{"key":"23_CR101","doi-asserted-by":"publisher","first-page":"35237","DOI":"10.1074\/JBC.R114.619304","volume":"289","author":"L Schaefer","year":"2014","unstructured":"Schaefer L (2014) Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem 289:35237\u201335245. https:\/\/doi.org\/10.1074\/JBC.R114.619304","journal-title":"J Biol Chem"},{"key":"23_CR102","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/J.JACI.2009.09.046","volume":"125","author":"HW Schroeder","year":"2010","unstructured":"Schroeder HW, Cavacini L (2010) Structure and function of immunoglobulins. J Allergy Clin Immunol 125:S41. https:\/\/doi.org\/10.1016\/J.JACI.2009.09.046","journal-title":"J Allergy Clin Immunol"},{"key":"23_CR103","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1210\/ENDREV\/BNAA016","volume":"41","author":"MCK Severinsen","year":"2020","unstructured":"Severinsen MCK, Pedersen BK (2020) Muscle\u2013organ crosstalk: the emerging roles of myokines. Endocr Rev 41:594\u2013609. https:\/\/doi.org\/10.1210\/ENDREV\/BNAA016","journal-title":"Endocr Rev"},{"key":"23_CR104","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3389\/FPHYS.2019.00709\/FULL","volume":"10","author":"Y Shi","year":"2019","unstructured":"Shi Y, Shi H et al (2019) Lactic acid accumulation during exhaustive exercise impairs release of neutrophil extracellular traps in mice. Front Physiol 10:709. https:\/\/doi.org\/10.3389\/FPHYS.2019.00709\/FULL","journal-title":"Front Physiol"},{"key":"23_CR105","first-page":"8","volume":"26","author":"RJ Simpson","year":"2020","unstructured":"Simpson RJ, Campbell JP et al (2020) Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev 26:8\u201322","journal-title":"Exerc Immunol Rev"},{"key":"23_CR106","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/CLIM.2000.4966","volume":"98","author":"MJ Spencer","year":"2001","unstructured":"Spencer MJ, Montecino-Rodriguez E, Dorshkind K, Tidball JG (2001) Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle. Clin Immunol 98:235\u2013243. https:\/\/doi.org\/10.1006\/CLIM.2000.4966","journal-title":"Clin Immunol"},{"key":"23_CR107","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","volume":"285","author":"A Steensberg","year":"2003","unstructured":"Steensberg A, Fischer CP, Keller C, M\u00f8ller K, Pedersen BK (2003) IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 285:E433","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"23_CR108","doi-asserted-by":"publisher","first-page":"565","DOI":"10.33549\/PHYSIOLRES.934371","volume":"69","author":"A Sto\u017eer","year":"2020","unstructured":"Sto\u017eer A, Vodopivc P, Bombek LK (2020) Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences. Physiol Res 69:565. https:\/\/doi.org\/10.33549\/PHYSIOLRES.934371","journal-title":"Physiol Res"},{"issue":"1","key":"23_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-023-01471-y","volume":"8","author":"L Sun","year":"2023","unstructured":"Sun L, Su Y, Jiao A, Wang X, Zhang B (2023) T cells in health and disease. Signal Transduct Target Ther 8(1):1\u201350. https:\/\/doi.org\/10.1038\/s41392-023-01471-y","journal-title":"Signal Transduct Target Ther"},{"key":"23_CR110","doi-asserted-by":"publisher","unstructured":"Sutton BJ, Davies AM, Bax HJ, Karagiannis SN (2019) IgE antibodies: from structure to function and clinical translation. Antibodies (Basel, Switzerland) 8. https:\/\/doi.org\/10.3390\/ANTIB8010019","DOI":"10.3390\/ANTIB8010019"},{"key":"23_CR111","doi-asserted-by":"publisher","first-page":"16295","DOI":"10.1101\/CSHPERSPECT.A016295","volume":"6","author":"T Tanaka","year":"2014","unstructured":"Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6:16295\u201316296. https:\/\/doi.org\/10.1101\/CSHPERSPECT.A016295","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"23_CR112","doi-asserted-by":"publisher","unstructured":"Taylor BC, Balko JM (2022) Mechanisms of MHC-I downregulation and role in immunotherapy response. Front Immunol 13. https:\/\/doi.org\/10.3389\/FIMMU.2022.844866","DOI":"10.3389\/FIMMU.2022.844866"},{"key":"23_CR113","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/MUS.10453","volume":"28","author":"CFP Teixeira","year":"2003","unstructured":"Teixeira CFP, Zamun\u00e9r SR et al (2003) Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom. Muscle Nerve 28:449\u2013459. https:\/\/doi.org\/10.1002\/MUS.10453","journal-title":"Muscle Nerve"},{"key":"23_CR114","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1152\/AJPREGU.00735.2009\/ASSET\/IMAGES\/LARGE\/ZH60051071990005.JPEG","volume":"298","author":"JG Tidball","year":"2010","unstructured":"Tidball JG, Villalta SA (2010) Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol 298:1173\u20131187. https:\/\/doi.org\/10.1152\/AJPREGU.00735.2009\/ASSET\/IMAGES\/LARGE\/ZH60051071990005.JPEG","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"23_CR115","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1113\/JPHYSIOL.2006.118265","volume":"578","author":"JG Tidball","year":"2007","unstructured":"Tidball JG, Wehling-Henricks M (2007) Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo. J Physiol 578:327\u2013336. https:\/\/doi.org\/10.1113\/JPHYSIOL.2006.118265","journal-title":"J Physiol"},{"key":"23_CR116","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1189\/jlb.0408244","volume":"84","author":"KL Timmerman","year":"2008","unstructured":"Timmerman KL, Flynn MG, Coen PM, Markofski MM, Pence BD (2008) Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise? J Leukoc Biol 84:1271\u20131278. https:\/\/doi.org\/10.1189\/jlb.0408244","journal-title":"J Leukoc Biol"},{"key":"23_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2021.109246","volume":"35","author":"M Trauelsen","year":"2021","unstructured":"Trauelsen M, Hiron TK et al (2021) Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1\/GPR91-mediated Gq signaling. Cell Rep 35:109246. https:\/\/doi.org\/10.1016\/J.CELREP.2021.109246","journal-title":"Cell Rep"},{"key":"23_CR118","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1016\/J.JACI.2009.07.016","volume":"125","author":"SE Turvey","year":"2010","unstructured":"Turvey SE, Broide DH (2010) Chapter 2: innate immunity. J Allergy Clin Immunol 125:S24. https:\/\/doi.org\/10.1016\/J.JACI.2009.07.016","journal-title":"J Allergy Clin Immunol"},{"key":"23_CR119","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1055\/S-2007-1021028","volume":"15","author":"N Tvede","year":"1994","unstructured":"Tvede N, Kappel M et al (1994) Evidence that the effect of bicycle exercise on blood mononuclear cell proliferative responses and subsets is mediated by epinephrine. Int J Sports Med 15:100\u2013104. https:\/\/doi.org\/10.1055\/S-2007-1021028","journal-title":"Int J Sports Med"},{"key":"23_CR120","first-page":"6","volume":"17","author":"NP Walsh","year":"2011","unstructured":"Walsh NP, Gleeson M et al (2011) Position statement. Part one: Immune function and exercise. Exerc Immunol Rev 17:6\u201363","journal-title":"Exerc Immunol Rev"},{"key":"23_CR121","doi-asserted-by":"publisher","unstructured":"Walter EJ, Hanna-Jumma S, Carraretto M, Forni L (2016) The pathophysiological basis and consequences of fever. Crit Care 20. https:\/\/doi.org\/10.1186\/S13054-016-1375-5","DOI":"10.1186\/S13054-016-1375-5"},{"key":"23_CR122","doi-asserted-by":"publisher","unstructured":"Walton RG, Kosmac K et al (2019) Human skeletal muscle macrophages increase following cycle training and are associated with adaptations that may facilitate growth. Sci Rep 9. https:\/\/doi.org\/10.1038\/S41598-018-37187-1","DOI":"10.1038\/S41598-018-37187-1"},{"key":"23_CR123","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/S00441-017-2785-7\/FIGURES\/1","volume":"371","author":"J Wang","year":"2018","unstructured":"Wang J (2018) Neutrophils in tissue injury and repair. Cell Tissue Res 371:531\u2013539. https:\/\/doi.org\/10.1007\/S00441-017-2785-7\/FIGURES\/1","journal-title":"Cell Tissue Res"},{"key":"23_CR124","doi-asserted-by":"publisher","DOI":"10.15252\/EMBR.201947892","volume":"20","author":"T Wang","year":"2019","unstructured":"Wang T, Xu Y-Q et al (2019) Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling. EMBO Rep 20:e47892. https:\/\/doi.org\/10.15252\/EMBR.201947892","journal-title":"EMBO Rep"},{"key":"23_CR125","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/J.CMET.2018.12.007","volume":"29","author":"AS Wedell-Neergaard","year":"2019","unstructured":"Wedell-Neergaard AS, Lang Lehrskov L et al (2019) Exercise-induced changes in visceral adipose tissue Mass are regulated by IL-6 signaling: a randomized controlled trial. Cell Metab 29:844\u2013855.e3. https:\/\/doi.org\/10.1016\/J.CMET.2018.12.007","journal-title":"Cell Metab"},{"key":"23_CR126","doi-asserted-by":"publisher","unstructured":"Wehling-Henricks M, Jordan MC et al (2010) Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One 5. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0010763","DOI":"10.1371\/JOURNAL.PONE.0010763"},{"key":"23_CR127","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/WOUND.2012.0383","volume":"2","author":"TA Wilgus","year":"2013","unstructured":"Wilgus TA, Roy S, McDaniel JC (2013) Neutrophils and wound repair: positive actions and negative. Reactions 2:379\u2013388. https:\/\/doi.org\/10.1089\/WOUND.2012.0383. https:\/\/home.liebertpub.com\/wound","journal-title":"Reactions"},{"key":"23_CR128","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2017.00403\/BIBTEX","volume":"8","author":"A Yamada","year":"2017","unstructured":"Yamada A, Arakaki R, Saito M, Kudo Y, Ishimaru N (2017) Dual role of Fas\/FasL-mediated signal in peripheral immune tolerance. Front Immunol 8:217624. https:\/\/doi.org\/10.3389\/FIMMU.2017.00403\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR129","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.00484\/BIBTEX","volume":"11","author":"H Yang","year":"2020","unstructured":"Yang H, Wang H, Andersson U (2020) Targeting inflammation driven by HMGB1. Front Immunol 11:526761. https:\/\/doi.org\/10.3389\/FIMMU.2020.00484\/BIBTEX","journal-title":"Front Immunol"},{"key":"23_CR130","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/MUS.25973","volume":"57","author":"JS Yi","year":"2018","unstructured":"Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O\u2019Connor KC (2018) B cells in the pathophysiology of myasthenia gravis. Muscle Nerve 57:172\u2013184. https:\/\/doi.org\/10.1002\/MUS.25973","journal-title":"Muscle Nerve"},{"key":"23_CR131","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D, Tang Z et al (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574:575\u2013580. https:\/\/doi.org\/10.1038\/s41586-019-1678-1","journal-title":"Nature"},{"key":"23_CR132","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.4049\/JIMMUNOL.1303486","volume":"193","author":"J Zhang","year":"2014","unstructured":"Zhang J, Xiao Z et al (2014) CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration. J Immunol 193:5149\u20135160. https:\/\/doi.org\/10.4049\/JIMMUNOL.1303486","journal-title":"J Immunol"},{"key":"23_CR133","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Raoof M et al (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104\u2013107. https:\/\/doi.org\/10.1038\/nature08780","journal-title":"Nature"},{"issue":"6","key":"23_CR134","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","volume":"30","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T, Elinav E (2020) Interaction between microbiota and immunity in health and disease. Cell Res 30(6):492\u2013506. https:\/\/doi.org\/10.1038\/s41422-020-0332-7","journal-title":"Cell Res"},{"key":"23_CR135","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1136\/BMJ.321.7271.1237","volume":"321","author":"JN Zuckerman","year":"2000","unstructured":"Zuckerman JN (2000) The importance of injecting vaccines into muscle: different patients need different needle sizes. BMJ 321:1237. https:\/\/doi.org\/10.1136\/BMJ.321.7271.1237","journal-title":"BMJ"}],"container-title":["Advances in Experimental Medicine and Biology","The Skeletal Muscle: Plasticity, Degeneration and Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-88361-3_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:17:33Z","timestamp":1785521853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-88361-3_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031883606","9783031883613"],"references-count":135,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-88361-3_23","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"30 August 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}