{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:00:31Z","timestamp":1780732831807,"version":"3.54.1"},"publisher-location":"Cham","reference-count":24,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031898433","type":"print"},{"value":"9783031898440","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":190,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: We aimed to identify unfavorable prognostic factors for the development of cerebral ischemic complications of surgical treatment in patients with moyamoya disease.<\/jats:p>\n                  <jats:p>Methods: We analyzed 80 patients with moyamoya disease, who underwent 134 surgical revascularizations. Persistent complications (ischemic strokes) developed in seven cases (5.3%). In 36 cases (27%), there were short-term episodes of transient neurologic deficit.<\/jats:p>\n                  <jats:p>\n                    Results: The statistical analysis revealed factors associated with the development of transient and persistent ischemic complications: neuroradiological \u201civy sign\u201d (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a04.078,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.043), stenosis of the ICA proximal to the PComA or PCA (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a020.085,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001), decompensation of cerebral blood flow (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a011.212,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), recent CVA (less than 3\u00a0months before surgery) or instability of neurological symptoms (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a06.146,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.013). Significant factors of the development of persistent ischemic stroke were as follows: stenosis or occlusion of the ipsilateral PCA (increasing the risk of stroke by 9.7 times); signs of the decompensation of cerebral perfusion (increased risk by 5.4 times); and unstable clinical symptoms within 3\u00a0months before surgery (increased risk by 6.4 times). The presence of at least two signs defines a group of patients that has an increased risk of complications with a sensitivity of 80.7% and a specificity of 88.6%.\n                  <\/jats:p>\n                  <jats:p>Conclusion: The identified risk factors will enable predicting the risk of perioperative ischemic complications in patients with moyamoya disease and optimize management tactics and improve the results of surgical treatment.<\/jats:p>","DOI":"10.1007\/978-3-031-89844-0_10","type":"book-chapter","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:43:07Z","timestamp":1752140587000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Ischemic Complications of Surgical Treatment in Patients with Moyamoya Disease"],"prefix":"10.1007","author":[{"given":"Anna A.","family":"Shulgina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily A.","family":"Lukshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton A.","family":"Korshunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry Yu.","family":"Usachev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"5","key":"10_CR1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3171\/2009.4.JNS081649","volume":"111","author":"R Guzman","year":"2009","unstructured":"Guzman R, Lee M, Achrol A, Bell-Stephens T, Kelly M, Do HM, Marks MP, Steinberg GK. 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