{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:00:29Z","timestamp":1780732829053,"version":"3.54.1"},"publisher-location":"Cham","reference-count":9,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031898433","type":"print"},{"value":"9783031898440","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":190,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Having a paraspinal arteriovenous shunt located in the paraspinal region outside the spinal canal is rare. Germline phosphatase and tensin homolog gene (PTEN) mutations have been noted in cases with a specific paraspinal arteriovenous shunt. We report a patient with a paraspinal arteriovenous shunt with multiple primary cancers and report a germline mutation diagnosed with PTEN hamartoma syndrome. PTEN hamartoma syndrome can manifest as various cancers. Early diagnosis of PTEN hamartoma syndrome is essential for improving patient prognosis and life expectancy. The coexistence of multiple primary cancers and vascular malformations can be considered red flags for PTEN hamartoma syndrome.<\/jats:p>","DOI":"10.1007\/978-3-031-89844-0_8","type":"book-chapter","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:41:45Z","timestamp":1752140505000},"page":"69-71","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paraspinal Arteriovenous Shunt Associated with PTEN Hamartoma Tumor Syndrome: A Case Report and Literature Review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-5719","authenticated-orcid":false,"given":"Sayaka","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hatsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"12","key":"8_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2021.104364","volume":"64","author":"MMCM Drissen","year":"2021","unstructured":"Drissen MMCM, Schieving JH, Schuurs-Hoeijmakers JHM, Vos JR, Hoogerbrugge N. Red flags for early recognition of adult patients with PTEN Hamartoma Tumour Syndrome. Eur J Med Genet. 2021;64(12):104364.","journal-title":"Eur J Med Genet"},{"issue":"12","key":"8_CR2","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1161\/STROKEAHA.120.033963","volume":"52","author":"Y Feng","year":"2021","unstructured":"Feng Y, Yu J, Xu J, He C, Bian L, Li G, Ye M, Hu P, Sun L, Jiang N, Ling F, Hong T, Zhang H. Natural history and clinical outcomes of paravertebral arteriovenous shunts. Stroke. 2021;52(12):3873\u201382.","journal-title":"Stroke"},{"issue":"7","key":"8_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2022.104533","volume":"65","author":"LAJ Hendricks","year":"2022","unstructured":"Hendricks LAJ, Schuurs-Hoeijmakers J, Spier I, Haadsma ML, Eijkelenboom A, Cremer K, Mensenkamp AR, Aretz S, Vos JR, Hoogerbrugge N. Catch them if you are aware: PTEN postzygotic mosaicism in clinically suspicious patients with PTEN Hamartoma Tumour Syndrome and literature review. Eur J Med Genet. 2022;65(7):104533.","journal-title":"Eur J Med Genet"},{"issue":"8","key":"8_CR4","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s00586-021-06831-2","volume":"30","author":"JH Kim","year":"2021","unstructured":"Kim JH, Yoon SH, Park SQ, Ban SP, Cho BK. Clinical features and treatment strategy of paraspinal arteriovenous shunt (PAVS): a systematic review with individual participants data meta-analysis. Eur Spine J. 2021;30(8):2385\u2013400.","journal-title":"Eur Spine J"},{"issue":"4","key":"8_CR5","doi-asserted-by":"publisher","first-page":"a036087","DOI":"10.1101\/cshperspect.a036087","volume":"10","author":"J Ngeow","year":"2020","unstructured":"Ngeow J, Eng C. PTEN in hereditary and sporadic cancer. Cold Spring Harb Perspect Med. 2020;10(4):a036087.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"21","key":"8_CR6","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1093\/jnci\/djt277","volume":"105","author":"R Pilarski","year":"2013","unstructured":"Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. J Natl Cancer Inst. 2013;105(21):1607\u201316.","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"8_CR7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1136\/jmg.2011.088807","volume":"48","author":"R Pilarski","year":"2011","unstructured":"Pilarski R, Stephens JA, Noss R, Fisher JL, Prior TW. Predicting PTEN mutations: an evaluation of Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome clinical features. J Med Genet. 2011;48(8):505\u201312.","journal-title":"J Med Genet"},{"issue":"3","key":"8_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0720-048X(03)00093-7","volume":"46","author":"G Rodesch","year":"2003","unstructured":"Rodesch G, Lasjaunias P. Spinal cord arteriovenous shunts: from imaging to management. Eur J Radiol. 2003;46(3):221\u201332.","journal-title":"Eur J Radiol"},{"issue":"1088","key":"8_CR9","doi-asserted-by":"publisher","first-page":"20170337","DOI":"10.1259\/bjr.20170337","volume":"91","author":"CM Wendl","year":"2018","unstructured":"Wendl CM, Aguilar P\u00e9rez M, Felber S, Stroszczynski C, B\u00e4zner H, Henkes H. Paraspinal arteriovenous fistula: Stuttgart classification based on experience and a review of the literature. Br J Radiol. 2018;91(1088):20170337.","journal-title":"Br J Radiol"}],"container-title":["Acta Neurochirurgica Supplement","Trends in the Treatment of Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-89844-0_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:28:11Z","timestamp":1780730891000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-89844-0_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031898433","9783031898440"],"references-count":9,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-89844-0_8","relation":{},"ISSN":["0065-1419","2197-8395"],"issn-type":[{"value":"0065-1419","type":"print"},{"value":"2197-8395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"10 July 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Competing interests\n                      :\u2002The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent\n                      :\u2002The patient signed informed consent regarding publishing her data and photographs.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"EJCVC","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"European \u2013 Japanese Cerebrovascular Congress","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Kyoto","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Japan","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2022","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"13 November 2022","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"16 November 2022","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"ejcvc2022","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/site.convention.co.jp\/ejcvc2020\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}