{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:43:00Z","timestamp":1757626980722,"version":"3.44.0"},"publisher-location":"Cham","reference-count":85,"publisher":"Springer Nature Switzerland","isbn-type":[{"type":"print","value":"9783031949272"},{"type":"electronic","value":"9783031949289"}],"license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-031-94928-9_19","type":"book-chapter","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T09:47:03Z","timestamp":1756633623000},"page":"251-267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling Insect Immunity: A Cross-Order Comparative Genomic Analysis of Key Immune Proteins"],"prefix":"10.1007","author":[{"given":"Triveni","family":"Shelke","sequence":"first","affiliation":[]},{"given":"Vanika","family":"Gupta","sequence":"additional","affiliation":[]},{"given":"Ishaan","family":"Gupta","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"19_CR1","doi-asserted-by":"publisher","unstructured":"Alekseev, V., Napreenko, M., Napreenko-Dorokhova, T.: Ecological groups of Coleoptera (Insecta) as indicators of habitat transformation on drained and rewetted peatlands: a baseline study from a carbon supersite, Kaliningrad, Russia. Insects 15(5) (2024). https:\/\/doi.org\/10.3390\/insects15050356","DOI":"10.3390\/insects15050356"},{"key":"19_CR2","doi-asserted-by":"publisher","unstructured":"Asma, H., et al.: Regulatory genome annotation of 33 insect species. eLife 13 (2024). https:\/\/doi.org\/10.7554\/eLife.96738","DOI":"10.7554\/eLife.96738"},{"issue":"1","key":"19_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2006.07.002","volume":"25","author":"J Bangham","year":"2006","unstructured":"Bangham, J., Jiggins, F., Lemaitre, B.: Insect immunity: the post-genomic era. Immunity 25(1), 1\u20135 (2006)","journal-title":"Immunity"},{"issue":"5","key":"19_CR4","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/icb\/icp043","volume":"49","author":"TJ Bradley","year":"2009","unstructured":"Bradley, T.J., et al.: Episodes in insect evolution. Integr. Comp. Biol. 49(5), 590\u2013606 (2009)","journal-title":"Integr. Comp. Biol."},{"issue":"7","key":"19_CR5","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cub.2017.03.027","volume":"27","author":"MG Branstetter","year":"2017","unstructured":"Branstetter, M.G., et al.: Phylogenomic insights into the evolution of stinging wasps and the origins of ants and bees. Curr. Biol. CB 27(7), 1019\u20131025 (2017)","journal-title":"Curr. Biol. CB"},{"key":"19_CR6","doi-asserted-by":"publisher","unstructured":"Breeschoten, T., van der Linden, C.F.H., Ros, V.I.D., Schranz, M.E., Simon, S.: Expanding the menu: are polyphagy and gene family expansions linked across lepidoptera? Genome Biol. Evol. 14(1) (2022). https:\/\/doi.org\/10.1093\/gbe\/evab283","DOI":"10.1093\/gbe\/evab283"},{"issue":"2","key":"19_CR7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1093\/molbev\/msj037","volume":"23","author":"MS Bulmer","year":"2006","unstructured":"Bulmer, M.S., Crozier, R.H.: Variation in positive selection in termite GNBPs and Relish. Mol. Biol. Evol. 23(2), 317\u2013326 (2006)","journal-title":"Mol. Biol. Evol."},{"key":"19_CR8","doi-asserted-by":"publisher","unstructured":"Cabral, S., et al.: (Diptera: Culicidae) immune responses with different feeding regimes following infection by the entomopathogenic fungus. Insects 11(2) (2020). https:\/\/doi.org\/10.3390\/insects11020095","DOI":"10.3390\/insects11020095"},{"key":"19_CR9","doi-asserted-by":"publisher","unstructured":"Chen, J., et al.: Contributes to reproductive diapause by regulating lipid storage and survival of (Linnaeus). Int. J. Mol. Sci. 24(1) (2022). https:\/\/doi.org\/10.3390\/ijms24010611","DOI":"10.3390\/ijms24010611"},{"issue":"17","key":"19_CR10","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen, S., Zhou, Y., Chen, Y., Gu, J.: Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34(17), i884\u2013i890 (2018)","journal-title":"Bioinformatics"},{"key":"19_CR11","doi-asserted-by":"crossref","unstructured":"Christophides, G.K., et al.: Immunity-related genes and gene families in Anopheles gambiae. Science 298(5591), 159\u2013165 (2002)","DOI":"10.1126\/science.1077136"},{"key":"19_CR12","doi-asserted-by":"publisher","first-page":"19208","DOI":"10.1038\/srep19208","volume":"6","author":"FL Condamine","year":"2016","unstructured":"Condamine, F.L., Clapham, M.E., Kergoat, G.J.: Global patterns of insect diversification: towards a reconciliation of fossil and molecular evidence? Sci. Rep. 6, 19208 (2016)","journal-title":"Sci. Rep."},{"issue":"11","key":"19_CR13","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1093\/emboj\/21.11.2568","volume":"21","author":"E De Gregorio","year":"2002","unstructured":"De Gregorio, E., Spellman, P.T., Tzou, P., Rubin, G.M., Lemaitre, B.: The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J. 21(11), 2568\u20132579 (2002)","journal-title":"EMBO J."},{"issue":"8","key":"19_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006795","volume":"4","author":"D Destoumieux-Garz\u00f3n","year":"2009","unstructured":"Destoumieux-Garz\u00f3n, D., et al.: Spodoptera frugiperda X-tox protein, an immune-related defensin rosary, has lost the function of ancestral defensins. PLoS ONE 4(8), e6795 (2009)","journal-title":"PLoS ONE"},{"issue":"1","key":"19_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A., et al.: STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1), 15\u201321 (2013)","journal-title":"Bioinformatics"},{"key":"19_CR16","unstructured":"DrosEU \u2013 European Drosophila Population Genomics Consortium (n.d.). https:\/\/droseu.net\/. Accessed 7 Feb 2025"},{"key":"19_CR17","doi-asserted-by":"publisher","unstructured":"Eleftherianos, I.: Editorial: \u201cevolutionary genetics of insect innate immunity\u201d. Genes 12(5) (2021). https:\/\/doi.org\/10.3390\/genes12050725","DOI":"10.3390\/genes12050725"},{"key":"19_CR18","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ijbiomac.2021.09.082","volume":"191","author":"I Eleftherianos","year":"2021","unstructured":"Eleftherianos, I., et al.: Diversity of insect antimicrobial peptides and proteins - a functional perspective: a review. Int. J. Biol. Macromol. 191, 277\u2013287 (2021)","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"19_CR19","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s13059-019-1832-y","volume":"20","author":"DM Emms","year":"2019","unstructured":"Emms, D.M., Kelly, S.: OrthoFinder: phylogenetic orthology inference for comparative genomics. Genome Biol. 20(1), 238 (2019)","journal-title":"Genome Biol."},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ibmb.2013.10.008","volume":"44","author":"TY Est\u00e9vez-Lao","year":"2014","unstructured":"Est\u00e9vez-Lao, T.Y., Hillyer, J.F.: Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem. Mol. Biol. 44, 12\u201322 (2014)","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"5","key":"19_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2583.2006.00682.x","volume":"15","author":"JD Evans","year":"2006","unstructured":"Evans, J.D., et al.: Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol. Biol. 15(5), 645\u2013656 (2006)","journal-title":"Insect Mol. Biol."},{"issue":"3","key":"19_CR22","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bbagen.2011.07.011","volume":"1820","author":"DL Geiser","year":"2012","unstructured":"Geiser, D.L., Winzerling, J.J.: Insect transferrins: multifunctional proteins. Biochem. Biophys. Acta. 1820(3), 437\u2013451 (2012)","journal-title":"Biochem. Biophys. Acta."},{"key":"19_CR23","doi-asserted-by":"crossref","unstructured":"Gerardo, N.M., et al.: Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol. 11(2), R21 (2010)","DOI":"10.1186\/gb-2010-11-2-r21"},{"key":"19_CR24","unstructured":"GitHub - fethalen\/phylopypruner: Tree-based orthology inference with functionality for reducing contamination (n.d.). GitHub. https:\/\/github.com\/fethalen\/phylopypruner. Accessed 10 Feb 2025"},{"key":"19_CR25","unstructured":"GitHub - GSLBiotech\/mafft: Align multiple amino acid or nucleotide sequences (n.d.). GitHub. https:\/\/github.com\/GSLBiotech\/mafft. Accessed 6 Feb 2025"},{"key":"19_CR26","unstructured":"GitHub - moshi4\/CafePlotter: A tool for plotting CAFE5 gene family expansion\/contraction result (n.d.). GitHub.https:\/\/github.com\/moshi4\/CafePlotter. Accessed 6 Feb 2025"},{"key":"19_CR27","unstructured":"GitHub - nylander\/catfasta2phyml: Concatenates FASTA formatted files to one \u201cphyml\u201d (PHYLIP) formatted file (n.d.) GitHub.https:\/\/github.com\/nylander\/catfasta2phyml. Accessed 6 Feb 2025"},{"key":"19_CR28","doi-asserted-by":"publisher","unstructured":"Gramates, L.S., et al.: FlyBase: a guided tour of highlighted features. Genetics 220(4) (2022). https:\/\/doi.org\/10.1093\/genetics\/iyac035","DOI":"10.1093\/genetics\/iyac035"},{"key":"19_CR29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.coi.2019.11.008","volume":"62","author":"MA Hanson","year":"2020","unstructured":"Hanson, M.A., Lemaitre, B.: New insights on Drosophila antimicrobial peptide function in host defense and beyond. Curr. Opin. Immunol. 62, 22\u201330 (2020)","journal-title":"Curr. Opin. Immunol."},{"key":"19_CR30","doi-asserted-by":"publisher","unstructured":"Hanson, M.A., Dost\u00e1lov\u00e1, A., Ceroni, C., Poidevin, M., Kondo, S., Lema\u00eetre, B.: Correction: synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach. eLife 8 (2019a). https:\/\/doi.org\/10.7554\/eLife.48778","DOI":"10.7554\/eLife.48778"},{"key":"19_CR31","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.3389\/fimmu.2019.02620","volume":"10","author":"MA Hanson","year":"2019","unstructured":"Hanson, M.A., Lemaitre, B., Unckless, R.L.: Dynamic evolution of antimicrobial peptides underscores trade-offs between immunity and ecological fitness. Front. Immunol. 10, 2620 (2019b)","journal-title":"Front. Immunol."},{"key":"19_CR32","unstructured":"Harrison, P.W., et al.: Ensembl 2024. Nucleic Acids Res. 52(D1), D891\u2013D899 (2024)"},{"issue":"1","key":"19_CR33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/0952-7915(95)80022-0","volume":"7","author":"JA Hoffmann","year":"1995","unstructured":"Hoffmann, J.A.: Innate immunity of insects. Curr. Opin. Immunol. 7(1), 4\u201310 (1995)","journal-title":"Curr. Opin. Immunol."},{"key":"19_CR34","doi-asserted-by":"publisher","unstructured":"Hou, H.-X., Huang, D.-W., Xin, Z.-Z., Xiao, J.-H.: Genome-wide analysis of gene families of pattern recognition receptors in fig wasps (Hymenoptera, Chalcidea). Genes (2021) 12(12). https:\/\/doi.org\/10.3390\/genes12121952","DOI":"10.3390\/genes12121952"},{"issue":"13","key":"19_CR35","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1073\/pnas.1914830117","volume":"117","author":"I Iatsenko","year":"2020","unstructured":"Iatsenko, I., Marra, A., Boquete, J.-P., Pe\u00f1a, J., Lemaitre, B.: Iron sequestration by transferrin 1 mediates nutritional immunity in. Proc. Natl. Acad. Sci. U.S.A. 117(13), 7317\u20137325 (2020)","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"19_CR36","doi-asserted-by":"publisher","first-page":"7512","DOI":"10.1038\/s41467-022-35284-4","volume":"13","author":"C Jouault","year":"2022","unstructured":"Jouault, C., Nel, A., Perrichot, V., Legendre, F., Condamine, F.L.: Multiple drivers and lineage-specific insect extinctions during the Permo-Triassic. Nat. Commun. 13(1), 7512 (2022)","journal-title":"Nat. Commun."},{"key":"19_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ibmb.2017.08.007","volume":"89","author":"SG Kim","year":"2017","unstructured":"Kim, S.G., et al.: TmSR-C, scavenger receptor class C, plays a pivotal role in antifungal and antibacterial immunity in the coleopteran insect Tenebrio molitor. Insect Biochem. Mol. Biol. 89, 31\u201342 (2017)","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"1","key":"19_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.dci.2013.05.014","volume":"42","author":"A Kleino","year":"2014","unstructured":"Kleino, A., Silverman, N.: The Drosophila IMD pathway in the activation of the humoral immune response. Dev. Comp. Immunol. 42(1), 25\u201335 (2014)","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"19_CR39","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1038\/s41598-018-38384-8","volume":"9","author":"Y Kobayashi","year":"2019","unstructured":"Kobayashi, Y., et al.: Comparative analysis of seven types of superoxide dismutases for their ability to respond to oxidative stress in Bombyx mori. Sci. Rep. 9(1), 2170 (2019)","journal-title":"Sci. Rep."},{"issue":"7","key":"19_CR40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cub.2007.02.041","volume":"17","author":"E Kurucz","year":"2007","unstructured":"Kurucz, E., et al.: Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Curr. Biol. CB 17(7), 649\u2013654 (2007)","journal-title":"Curr. Biol. CB"},{"key":"19_CR41","doi-asserted-by":"crossref","unstructured":"Lamberty, M., et al.: Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity. J. Biol. Chem. 274(14), 9320\u20139326 (1999)","DOI":"10.1074\/jbc.274.14.9320"},{"issue":"2","key":"19_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004549","volume":"4","author":"T Lehmann","year":"2009","unstructured":"Lehmann, T., et al.: Molecular evolution of immune genes in the malaria mosquito Anopheles gambiae. PLoS ONE 4(2), e4549 (2009)","journal-title":"PLoS ONE"},{"issue":"W1","key":"19_CR43","doi-asserted-by":"publisher","first-page":"W78","DOI":"10.1093\/nar\/gkae268","volume":"52","author":"I Letunic","year":"2024","unstructured":"Letunic, I., Bork, P.: Interactive tree of life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool. Nucleic Acids Res. 52(W1), W78\u2013W82 (2024)","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"19_CR44","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1186\/s12864-021-07886-7","volume":"22","author":"LF Lima","year":"2021","unstructured":"Lima, L.F., Torres, A.Q., Jardim, R., Mesquita, R.D., Schama, R.: Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias. BMC Genomics 22(1), 562 (2021)","journal-title":"BMC Genomics"},{"key":"19_CR45","doi-asserted-by":"crossref","unstructured":"Lin, X., Feng, C., Lin, T., Harris, A.J., Li, Y., Kang, M.: Jackfruit genome and population genomics provide insights into fruit evolution and domestication history in China. Hortic. Res. 9, uhac173 (2022)","DOI":"10.1093\/hr\/uhac173"},{"key":"19_CR46","doi-asserted-by":"crossref","unstructured":"Liu, J., Shi, G.-P., Zhang, W.-Q., Zhang, G.-R., Xu, W.-H.: Cathepsin L function in insect moulting: molecular cloning and functional analysis in cotton bollworm, Helicoverpa armigera. Insect Mol. Biol. 15(6), 823\u2013834 (2006)","DOI":"10.1111\/j.1365-2583.2006.00686.x"},{"issue":"12","key":"19_CR47","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M.I., Huber, W., Anders, S.: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15(12), 550 (2014)","journal-title":"Genome Biol."},{"key":"19_CR48","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fphys.2014.00252","volume":"5","author":"A Lu","year":"2014","unstructured":"Lu, A., et al.: Insect prophenoloxidase: the view beyond immunity. Front. Physiol. 5, 252 (2014)","journal-title":"Front. Physiol."},{"key":"19_CR49","doi-asserted-by":"publisher","unstructured":"Lu, M., Cao, M., Yang, J., Swenson, N.G.: Comparative transcriptomics reveals divergence in pathogen response gene families amongst 20 forest tree species. G3 (Bethesda, Md.) 13(12) (2023). https:\/\/doi.org\/10.1093\/g3journal\/jkad233","DOI":"10.1093\/g3journal\/jkad233"},{"issue":"Pt A","key":"19_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131407","volume":"373","author":"J Ma","year":"2022","unstructured":"Ma, J., Faqir, Y., Tan, C., Khaliq, G.: Terrestrial insects as a promising source of chitosan and recent developments in its application for various industries. Food Chem. 373(Pt A), 131407 (2022)","journal-title":"Food Chem."},{"key":"19_CR51","doi-asserted-by":"publisher","first-page":"15031","DOI":"10.1038\/hortres.2015.31","volume":"2","author":"Y Ma","year":"2015","unstructured":"Ma, Y., Wang, J., Zhong, Y., Geng, F., Cramer, G.R., Cheng, Z.-M.M.: Subfunctionalization of cation\/proton antiporter 1 genes in grapevine in response to salt stress in different organs. Hortic. Res. 2, 15031 (2015)","journal-title":"Hortic. Res."},{"key":"19_CR52","doi-asserted-by":"publisher","first-page":"1169152","DOI":"10.3389\/fimmu.2023.1169152","volume":"14","author":"DK Mahanta","year":"2023","unstructured":"Mahanta, D.K., et al.: Insect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory function of non-coding RNAs. Front. Immunol. 14, 1169152 (2023)","journal-title":"Front. Immunol."},{"issue":"6","key":"19_CR53","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1101\/gr.115949.110","volume":"21","author":"P Markova-Raina","year":"2011","unstructured":"Markova-Raina, P., Petrov, D.: High sensitivity to aligner and high rate of false positives in the estimates of positive selection in the 12 Drosophila genomes. Genome Res. 21(6), 863\u2013874 (2011)","journal-title":"Genome Res."},{"key":"19_CR54","doi-asserted-by":"crossref","unstructured":"Martin, F.J., et al.: Ensembl 2023. Nucleic Acids Res. 51(D1), D933\u2013D941 (2022)","DOI":"10.1093\/nar\/gkac1014"},{"key":"19_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2023.104038","volume":"165","author":"N McCartney","year":"2024","unstructured":"McCartney, N., Kondakath, G., Tai, A., Trimmer, B.A.: Functional annotation of insecta transcriptomes: a cautionary tale from Lepidoptera. Insect Biochem. Mol. Biol. 165, 104038 (2024)","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"22\u201323","key":"19_CR56","doi-asserted-by":"publisher","first-page":"5516","DOI":"10.1093\/bioinformatics\/btaa1022","volume":"36","author":"FK Mendes","year":"2021","unstructured":"Mendes, F.K., Vanderpool, D., Fulton, B., Hahn, M.W.: CAFE 5 models variation in evolutionary rates among gene families. Bioinformatics 36(22\u201323), 5516\u20135518 (2021)","journal-title":"Bioinformatics"},{"issue":"5","key":"19_CR57","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","volume":"37","author":"BQ Minh","year":"2020","unstructured":"Minh, B.Q., et al.: IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era. Mol. Biol. Evol. 37(5), 1530\u20131534 (2020)","journal-title":"Mol. Biol. Evol."},{"key":"19_CR58","doi-asserted-by":"crossref","unstructured":"Misof, B., et al.: Phylogenomics resolves the timing and pattern of insect evolution. Science 346(6210), 763\u2013767 (2014)","DOI":"10.1126\/science.1257570"},{"key":"19_CR59","doi-asserted-by":"publisher","unstructured":"Mondal, S., Somani, J., Roy, S., Babu, A., Pandey, A.K.: Insect microbial symbionts: ecology, interactions, and biological significance. Microorganisms 11(11) (2023). https:\/\/doi.org\/10.3390\/microorganisms11112665","DOI":"10.3390\/microorganisms11112665"},{"issue":"2","key":"19_CR60","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/1744-7917.12783","volume":"28","author":"DG Najera","year":"2021","unstructured":"Najera, D.G., Dittmer, N.T., Weber, J.J., Kanost, M.R., Gorman, M.J.: Phylogenetic and sequence analyses of insect transferrins suggest that only transferrin 1 has a role in iron homeostasis. Insect Sci. 28(2), 495\u2013508 (2021)","journal-title":"Insect Sci."},{"issue":"6","key":"19_CR61","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cub.2006.01.065","volume":"16","author":"DJ Obbard","year":"2006","unstructured":"Obbard, D.J., Jiggins, F.M., Halligan, D.L., Little, T.J.: Natural selection drives extremely rapid evolution in antiviral RNAi genes. Curr. Biol. CB 16(6), 580\u2013585 (2006)","journal-title":"Curr. Biol. CB"},{"issue":"10","key":"19_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000698","volume":"5","author":"DJ Obbard","year":"2009","unstructured":"Obbard, D.J., Welch, J.J., Kim, K.-W., Jiggins, F.M.: Quantifying adaptive evolution in the Drosophila immune system. PLoS Genet. 5(10), e1000698 (2009)","journal-title":"PLoS Genet."},{"key":"19_CR63","doi-asserted-by":"crossref","unstructured":"Philips, J.A., Rubin, E.J., Perrimon, N.: Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science 309(5738), 1251\u20131253 (2005)","DOI":"10.1126\/science.1116006"},{"issue":"1","key":"19_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13355-020-00668-9","volume":"55","author":"RA Raguso","year":"2020","unstructured":"Raguso, R.A.: Don\u2019t forget the flies: dipteran diversity and its consequences for floral ecology and evolution. Appl. Entomol. Zool. 55(1), 1\u20137 (2020)","journal-title":"Appl. Entomol. Zool."},{"issue":"7","key":"19_CR65","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1093\/molbev\/msu141","volume":"31","author":"J Roux","year":"2014","unstructured":"Roux, J., Privman, E., Moretti, S., Daub, J.T., Robinson-Rechavi, M., Keller, L.: Patterns of positive selection in seven ant genomes. Mol. Biol. Evol. 31(7), 1661\u20131685 (2014)","journal-title":"Mol. Biol. Evol."},{"issue":"12","key":"19_CR66","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/ng.2007.60","volume":"39","author":"TB Sackton","year":"2007","unstructured":"Sackton, T.B., Lazzaro, B.P., Schlenke, T.A., Evans, J.D., Hultmark, D., Clark, A.G.: Dynamic evolution of the innate immune system in Drosophila. Nat. Genet. 39(12), 1461\u20131468 (2007)","journal-title":"Nat. Genet."},{"key":"19_CR67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ibmb.2015.07.005","volume":"64","author":"N Saikhedkar","year":"2015","unstructured":"Saikhedkar, N., Summanwar, A., Joshi, R., Giri, A.: Cathepsins of lepidopteran insects: aspects and prospects. Insect Biochem. Mol. Biol. 64, 51\u201359 (2015)","journal-title":"Insect Biochem. Mol. Biol."},{"key":"19_CR68","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.3389\/fmicb.2019.02466","volume":"10","author":"NB Sanda","year":"2019","unstructured":"Sanda, N.B., Hou, B., Muhammad, A., Ali, H., Hou, Y.: Exploring the role of relish on antimicrobial peptide expressions (AMPs) upon nematode-bacteria complex challenge in the nipa palm hispid beetle, Maulik (Coleoptera: Chrysomelidae). Front. Microbiol. 10, 2466 (2019)","journal-title":"Front. Microbiol."},{"key":"19_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/542139","volume":"2013","author":"Y Seto","year":"2013","unstructured":"Seto, Y., Tamura, K.: Extensive differences in antifungal immune response in two Drosophila species revealed by comparative transcriptome analysis. Int. J. Genomics 2013, 542139 (2013)","journal-title":"Int. J. Genomics"},{"key":"19_CR70","doi-asserted-by":"publisher","unstructured":"Shultz, A.J., Sackton, T.B.: Immune genes are hotspots of shared positive selection across birds and mammals. eLife 8 (2019). https:\/\/doi.org\/10.7554\/eLife.41815","DOI":"10.7554\/eLife.41815"},{"issue":"2","key":"19_CR71","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/sysbio\/sys087","volume":"62","author":"T Stadler","year":"2013","unstructured":"Stadler, T., Bokma, F.: Estimating speciation and extinction rates for phylogenies of higher taxa. Syst. Biol. 62(2), 220\u2013230 (2013)","journal-title":"Syst. Biol."},{"key":"19_CR72","doi-asserted-by":"publisher","unstructured":"Starr, S.M., Wallace, J.R.: Ecology and biology of aquatic insects. Insects 12(1) (2021). https:\/\/doi.org\/10.3390\/insects12010051","DOI":"10.3390\/insects12010051"},{"key":"19_CR73","doi-asserted-by":"crossref","unstructured":"Suyama, M., Torrents, D.,  Bork, P.: PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments. Nucleic Acids Res. 34, W609\u2013W612 (2006). Web Server issue","DOI":"10.1093\/nar\/gkl315"},{"issue":"12","key":"19_CR74","doi-asserted-by":"publisher","first-page":"4578","DOI":"10.1128\/MCB.01814-06","volume":"27","author":"T Tanji","year":"2007","unstructured":"Tanji, T., Hu, X., Weber, A.N.R., Ip, Y.T.: Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Mol. Cell Biol. 27(12), 4578\u20134588 (2007)","journal-title":"Mol. Cell Biol."},{"key":"19_CR75","doi-asserted-by":"crossref","unstructured":"The effects of agrochemicals on Lepidoptera, with a focus on moths, and their pollination service in field margin habitats. Agric. Ecosyst. Environ. 207, 153\u2013162 (2015)","DOI":"10.1016\/j.agee.2015.04.002"},{"issue":"6","key":"19_CR76","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/bfgp\/elv002","volume":"14","author":"L Viljakainen","year":"2015","unstructured":"Viljakainen, L.: Evolutionary genetics of insect innate immunity. Brief. Funct. Genomics 14(6), 407\u2013412 (2015)","journal-title":"Brief. Funct. Genomics"},{"key":"19_CR77","doi-asserted-by":"crossref","unstructured":"Wang, P., et al.: The genome evolution and domestication of tropical fruit mango. Genome Biol. 21(1) 60 (2020)","DOI":"10.1186\/s13059-020-01959-8"},{"issue":"3\u20134","key":"19_CR78","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12551-014-0142-6","volume":"6","author":"M Williams","year":"2014","unstructured":"Williams, M., Baxter, R.: The structure and function of thioester-containing proteins in arthropods. Biophys. Rev. 6(3\u20134), 261\u2013272 (2014)","journal-title":"Biophys. Rev."},{"issue":"1","key":"19_CR79","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/jee\/tox321","volume":"111","author":"S-F Wu","year":"2018","unstructured":"Wu, S.-F., Li, J., Zhang, Y., Gao, C.-F.: Transferrin family genes in the brown Planthopper, Nilaparvata lugens (Hemiptera: Delphacidae) in response to three insecticides. J. Econ. Entomol. 111(1), 375\u2013381 (2018)","journal-title":"J. Econ. Entomol."},{"issue":"1","key":"19_CR80","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12864-023-09446-7","volume":"24","author":"X Wu","year":"2023","unstructured":"Wu, X., et al.: Genome-wide identification and immune response analysis of mitogen-activated protein kinase cascades in tea geometrid, Ectropis grisescens Warren (Geometridae, Lepidoptera). BMC Genomics 24(1), 344 (2023)","journal-title":"BMC Genomics"},{"issue":"8","key":"19_CR81","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/molbev\/msm088","volume":"24","author":"Z Yang","year":"2007","unstructured":"Yang, Z.: PAML 4: phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24(8), 1586\u20131591 (2007)","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"19_CR82","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1186\/s12864-018-4783-x","volume":"19","author":"C Yin","year":"2018","unstructured":"Yin, C., et al.: The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum. BMC Genomics 19(1), 420 (2018)","journal-title":"BMC Genomics"},{"key":"19_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.905370","volume":"13","author":"S Yu","year":"2022","unstructured":"Yu, S., Luo, F., Xu, Y., Zhang, Y., Jin, L.H.: Innate immunity involves multiple signaling pathways and coordinated communication between different tissues. Front. Immunol. 13, 905370 (2022)","journal-title":"Front. Immunol."},{"issue":"4\u20135","key":"19_CR84","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0965-1748(00)00155-7","volume":"31","author":"X Zhao","year":"2001","unstructured":"Zhao, X., Smartt, C.T., Li, J., Christensen, B.M.: Aedes aegypti peroxidase gene characterization and developmental expression. Insect Biochem. Mol. Biol. 31(4\u20135), 481\u2013490 (2001)","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"4","key":"19_CR85","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ygeno.2008.12.010","volume":"93","author":"Z Zou","year":"2009","unstructured":"Zou, Z., Picheng, Z., Weng, H., Mita, K., Jiang, H.: A comparative analysis of serpin genes in the silkworm genome. Genomics 93(4), 367\u2013375 (2009)","journal-title":"Genomics"}],"container-title":["Lecture Notes in Computer Science","Comparative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-94928-9_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:26:42Z","timestamp":1757464002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-94928-9_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"ISBN":["9783031949272","9783031949289"],"references-count":85,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-94928-9_19","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"1 September 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"RECOMB-CG","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"RECOMB International Workshop on Comparative Genomics","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Seoul","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Korea (Republic of)","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2025","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"24 April 2025","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"25 April 2025","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"22","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"rcg2025","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/recomb-cg-2025.github.io\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}