{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T11:58:51Z","timestamp":1780833531522,"version":"3.54.1"},"publisher-location":"Cham","reference-count":133,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031970344","type":"print"},{"value":"9783031970351","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-3-031-97035-1_6","type":"book-chapter","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T19:21:03Z","timestamp":1753989663000},"page":"101-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drosophila Intestine as a Model to Study\u00a0Tumors"],"prefix":"10.1007","author":[{"given":"Jiae","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young V.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"issue":"1","key":"6_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ydbio.2016.10.011","volume":"420","author":"P Aghajanian","year":"2016","unstructured":"Aghajanian P, Takashima S, Paul M, Younossi-Hartenstein A, Hartenstein V (2016) Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation. Dev Biol 420(1):43\u201359. https:\/\/doi.org\/10.1016\/j.ydbio.2016.10.011","journal-title":"Dev Biol"},{"issue":"1","key":"6_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2008.10.016","volume":"4","author":"A Amcheslavsky","year":"2009","unstructured":"Amcheslavsky A, Jiang J, Ip YT (2009) Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4(1):49\u201361. https:\/\/doi.org\/10.1016\/j.stem.2008.10.016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"6_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.celrep.2014.08.052","volume":"9","author":"A Amcheslavsky","year":"2014","unstructured":"Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, Perrimon N, Ip YT (2014) Enteroendocrine cells support intestinal stem cell-mediated homeostasis in Drosophila. Cell Rep 9(1):32\u201339. https:\/\/doi.org\/10.1016\/j.celrep.2014.08.052","journal-title":"Cell Rep"},{"issue":"3","key":"6_CR4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1080\/19336934.2016.1140709","volume":"9","author":"ZA Antonello","year":"2015","unstructured":"Antonello ZA, Reiff T, Dominguez M (2015a) Mesenchymal to epithelial transition during tissue homeostasis and regeneration: patching up the Drosophila midgut epithelium. Fly 9(3):132\u2013137. https:\/\/doi.org\/10.1080\/19336934.2016.1140709","journal-title":"Fly"},{"key":"6_CR5","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591517","volume":"15","author":"ZA Antonello","year":"2015","unstructured":"Antonello ZA, Reiff T, Ballesta-Illan E, Dominguez M (2015b) Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8\u2013Escargot switch. EMBO J 15:e201591517. https:\/\/doi.org\/10.15252\/embj.201591517","journal-title":"EMBO J"},{"key":"6_CR6","doi-asserted-by":"publisher","first-page":"13615","DOI":"10.1038\/ncomms13615","volume":"7","author":"E Bangi","year":"2016","unstructured":"Bangi E (2016) Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun 7:13615","journal-title":"Nat Commun"},{"issue":"5","key":"6_CR7","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1126\/sciadv.aav6528","volume":"5","author":"E Bangi","year":"2019","unstructured":"Bangi E (2019) A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Sci Adv 5(5):6528","journal-title":"Sci Adv"},{"issue":"6","key":"6_CR8","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/embor.2012.44","volume":"13","author":"E Bangi","year":"2012","unstructured":"Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y (2012) Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep 13(6):569\u2013576. https:\/\/doi.org\/10.1038\/embor.2012.44","journal-title":"EMBO Rep"},{"key":"6_CR9","doi-asserted-by":"publisher","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"VE Baracos","year":"2018","unstructured":"Baracos VE (2018) Cancer-associated cachexia. Nat Rev Dis Primers 4:17105","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"6_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2009.10.045","volume":"338","author":"K Beebe","year":"2010","unstructured":"Beebe K, Lee W-C, Micchelli CA (2010) JAK\/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol 338(1):28\u201337. https:\/\/doi.org\/10.1016\/j.ydbio.2009.10.045","journal-title":"Dev Biol"},{"key":"6_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.semcdb.2014.02.007","volume":"28","author":"GP Bell","year":"2014","unstructured":"Bell GP, Thompson BJ (2014) Colorectal cancer progression: lessons from Drosophila? Semin Cell Dev Biol 28:70\u201377. (Ligands for the Epidermal Growth Factor Receptor & Cancer models in Drosophila). https:\/\/doi.org\/10.1016\/j.semcdb.2014.02.007","journal-title":"Semin Cell Dev Biol"},{"issue":"11","key":"6_CR12","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41568-021-00387-5","volume":"21","author":"D Bilder","year":"2021","unstructured":"Bilder D (2021) Tumour-host interactions through the lens of Drosophila. Nat Rev Cancer 21(11):687\u2013700","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"6_CR13","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1242\/dev.056671","volume":"138","author":"B Biteau","year":"2011","unstructured":"Biteau B, Jasper H (2011) EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138(6):1045\u20131055. https:\/\/doi.org\/10.1242\/dev.056671","journal-title":"Development"},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ceb.2021.05.007","volume":"73","author":"B Boumard","year":"2021","unstructured":"Boumard B, Bardin AJ (2021) An amuse-bouche of stem cell regulation: underlying principles and mechanisms from adult Drosophila intestinal stem cells. Curr Opin Cell Biol 73:58\u201368","journal-title":"Curr Opin Cell Biol"},{"issue":"11","key":"6_CR15","doi-asserted-by":"publisher","first-page":"bio058623","DOI":"10.1242\/bio.058623","volume":"10","author":"R Br\u00e1s","year":"2021","unstructured":"Br\u00e1s R, Monteiro A, Sunkel CE, Resende LP (2021) Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut. Biol Open 10(11):bio058623. https:\/\/doi.org\/10.1242\/bio.058623","journal-title":"Biol Open"},{"issue":"19","key":"6_CR16","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1101\/gad.1827009","volume":"23","author":"N Buchon","year":"2009","unstructured":"Buchon N, Broderick NA, Chakrabarti S, Lemaitre B (2009) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23(19):2333\u20132344. https:\/\/doi.org\/10.1101\/gad.1827009","journal-title":"Genes Dev"},{"issue":"1","key":"6_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1741-7007-8-152","volume":"8","author":"N Buchon","year":"2010","unstructured":"Buchon N, Broderick NA, Kuraishi T, Lemaitre B (2010) DrosophilaEGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 8(1):152. https:\/\/doi.org\/10.1186\/1741-7007-8-152","journal-title":"BMC Biol"},{"issue":"5","key":"6_CR18","doi-asserted-by":"publisher","first-page":"ar46","DOI":"10.1091\/mbc.E23-03-0087","volume":"34","author":"AJH Cabrera","year":"2023","unstructured":"Cabrera AJH, Gumbiner BM, Kwon YV (2023) Remodeling of E-cadherin subcellular localization during cell dissemination. Mol Biol Cell 34(5):ar46. https:\/\/doi.org\/10.1091\/mbc.E23-03-0087","journal-title":"Mol Biol Cell"},{"issue":"1","key":"6_CR19","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1038\/s41467-019-10269-y","volume":"10","author":"K Campbell","year":"2019","unstructured":"Campbell K, Rossi F, Adams J, Pitsidianaki I, Barriga FM, Garcia-Gerique L, Batlle E, Casanova J, Casali A (2019) Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. Nat Commun 10(1):2311. https:\/\/doi.org\/10.1038\/s41467-019-10269-y","journal-title":"Nat Commun"},{"issue":"8","key":"6_CR20","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2013.05.002","volume":"19","author":"Y Cao","year":"2013","unstructured":"Cao Y (2013) Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis. Trends Mol Med 19(8):460\u2013473","journal-title":"Trends Mol Med"},{"issue":"3","key":"6_CR21","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/annonc\/mdy028","volume":"29","author":"P Carmeliet","year":"2018","unstructured":"Carmeliet P (2018) RAISEing VEGF-D\u2019s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients. Ann Oncol 29(3):529\u2013532","journal-title":"Ann Oncol"},{"issue":"26","key":"6_CR22","doi-asserted-by":"publisher","first-page":"14608","DOI":"10.1073\/pnas.97.26.14608","volume":"97","author":"YS Chang","year":"2000","unstructured":"Chang YS (2000) Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci USA 97(26):14608\u201314613","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-23629-8_1","volume":"1167","author":"D Chatterjee","year":"2019","unstructured":"Chatterjee D, Deng WM (2019) Drosophila model in cancer: an introduction. Adv Exp Med Biol 1167:1\u201314","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"6_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1534\/genetics.119.302289","volume":"214","author":"E Cohen","year":"2020","unstructured":"Cohen E, Sawyer JK, Peterson NG, Dow JAT, Fox DT (2020) Physiology, development, and disease modeling in the Drosophila excretory system. Genetics 214(2):235\u2013264. https:\/\/doi.org\/10.1534\/genetics.119.302289","journal-title":"Genetics"},{"issue":"1","key":"6_CR25","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1038\/s41467-020-17186-5","volume":"11","author":"CP Couturier","year":"2020","unstructured":"Couturier CP, Ayyadhury S, Le PU, Nadaf J, Monlong J, Riva G, Allache R, Baig S, Yan X, Bourgey M et al (2020) Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy. Nat Commun 11(1):3406. https:\/\/doi.org\/10.1038\/s41467-020-17186-5","journal-title":"Nat Commun"},{"issue":"11","key":"6_CR26","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1038\/emboj.2012.106","volume":"31","author":"J de Navascu\u00e9s","year":"2012","unstructured":"de Navascu\u00e9s J, Perdigoto CN, Bian Y, Schneider MH, Bardin AJ, Mart\u00ednez-Arias A, Simons BD (2012) Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells: Drosophila midgut homeostasis involves ISC neutral competition. EMBO J 31(11):2473\u20132485. https:\/\/doi.org\/10.1038\/emboj.2012.106","journal-title":"EMBO J"},{"issue":"7581","key":"6_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature16170","volume":"528","author":"H Deng","year":"2015","unstructured":"Deng H, Gerencser AA, Jasper H (2015) Signal integration by Ca2+ regulates intestinal stem-cell activity. Nature 528(7581):212\u2013217. https:\/\/doi.org\/10.1038\/nature16170","journal-title":"Nature"},{"issue":"7","key":"6_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109553","volume":"36","author":"G Ding","year":"2021","unstructured":"Ding G (2021) Coordination of tumor growth and host wasting by tumor-derived Upd3. Cell Rep 36(7):109553","journal-title":"Cell Rep"},{"issue":"3","key":"6_CR29","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/jcsm.12692","volume":"12","author":"J Dong","year":"2021","unstructured":"Dong J (2021) Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting. J Cachexia Sarcopenia Muscle 12(3):704\u2013716","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"48","key":"6_CR30","doi-asserted-by":"publisher","first-page":"12218","DOI":"10.1073\/pnas.1719169115","volume":"115","author":"DP Doup\u00e9","year":"2018","unstructured":"Doup\u00e9 DP, Marshall OJ, Dayton H, Brand AH, Perrimon N (2018) Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proc Natl Acad Sci 115(48):12218\u201312223. https:\/\/doi.org\/10.1073\/pnas.1719169115","journal-title":"Proc Natl Acad Sci"},{"key":"6_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/978-981-13-0529-0_10","volume":"1076","author":"M Enomoto","year":"2018","unstructured":"Enomoto M, Siow C, Igaki T (2018) Drosophila as a cancer model. Adv Exp Med Biol 1076:173\u2013194","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"6_CR32","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1083\/jcb.200802081","volume":"181","author":"OT Fackler","year":"2008","unstructured":"Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181(6):879\u2013884. https:\/\/doi.org\/10.1083\/jcb.200802081","journal-title":"J Cell Biol"},{"issue":"2","key":"6_CR33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","volume":"16","author":"KC Fearon","year":"2012","unstructured":"Fearon KC, Glass DJ, Guttridge DC (2012) Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab 16(2):153\u2013166","journal-title":"Cell Metab"},{"issue":"9","key":"6_CR34","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1016\/j.cell.2023.03.028","volume":"186","author":"M Ferrer","year":"2023","unstructured":"Ferrer M (2023) Cachexia: a systemic consequence of progressive, unresolved disease. Cell 186(9):1824\u20131845","journal-title":"Cell"},{"issue":"1","key":"6_CR35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.devcel.2015.03.001","volume":"33","author":"A Figueroa-Clarevega","year":"2015","unstructured":"Figueroa-Clarevega A, Bilder D (2015) Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting. Dev Cell 33(1):47\u201355","journal-title":"Dev Cell"},{"issue":"7","key":"6_CR36","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.3390\/ijms21072321","volume":"21","author":"G Fonseca","year":"2020","unstructured":"Fonseca G (2020) Cancer cachexia and related metabolic dysfunction. Int J Mol Sci 21(7):2321","journal-title":"Int J Mol Sci"},{"issue":"3","key":"6_CR37","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.stem.2009.06.003","volume":"5","author":"DT Fox","year":"2009","unstructured":"Fox DT, Spradling AC (2009) The drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell 5(3):290\u2013297. https:\/\/doi.org\/10.1016\/j.stem.2009.06.003","journal-title":"Cell Stem Cell"},{"issue":"1","key":"6_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF00577830","volume":"176","author":"E Gateff","year":"1974","unstructured":"Gateff E, Schneiderman HA (1974) Developmental capacities of benign and malignant neoplasms of Drosophila. Wilhelm Roux Arch Entwickl Mech Org 176(1):23\u201365","journal-title":"Wilhelm Roux Arch Entwickl Mech Org"},{"issue":"1","key":"6_CR39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2019.12.001","volume":"37","author":"J Goveia","year":"2020","unstructured":"Goveia J, Rohlenova K, Taverna F, Treps L, Conradi L-C, Pircher A, Geldhof V, de Rooij LPMH, Kalucka J, Sokol L et al (2020) An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates. Cancer Cell 37(1):21\u201336.e13. https:\/\/doi.org\/10.1016\/j.ccell.2019.12.001","journal-title":"Cancer Cell"},{"key":"6_CR40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.gde.2016.06.009","volume":"40","author":"Z Guo","year":"2016","unstructured":"Guo Z, Lucchetta E, Rafel N, Ohlstein B (2016) Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Curr Opin Genet Dev 40:81\u201386. (Cell reprogramming, regeneration and repair). https:\/\/doi.org\/10.1016\/j.gde.2016.06.009","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"6_CR41","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1038\/s41467-024-46956-8","volume":"15","author":"X Guo","year":"2024","unstructured":"Guo X, Wang C, Zhang Y, Wei R, Xi R (2024) Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor. Nat Commun 15(1):2656. https:\/\/doi.org\/10.1038\/s41467-024-46956-8","journal-title":"Nat Commun"},{"issue":"1","key":"6_CR42","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13550-021-00834-2","volume":"11","author":"J Han","year":"2021","unstructured":"Han J (2021) Imaging modalities for diagnosis and monitoring of cancer cachexia. EJNMMI Res 11(1):94","journal-title":"EJNMMI Res"},{"issue":"7694","key":"6_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature25744","volume":"555","author":"L He","year":"2018","unstructured":"He L, Si G, Huang J, Samuel ADT, Perrimon N (2018) Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature 555(7694):103\u2013106. https:\/\/doi.org\/10.1038\/nature25744","journal-title":"Nature"},{"issue":"3","key":"6_CR44","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.cell.2013.06.030","volume":"154","author":"S Hirabayashi","year":"2013","unstructured":"Hirabayashi S, Baranski TJ, Cagan RL (2013) Transformed drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell 154(3):664\u2013675. https:\/\/doi.org\/10.1016\/j.cell.2013.06.030","journal-title":"Cell"},{"issue":"3","key":"6_CR45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/jbiol72","volume":"7","author":"B Honegger","year":"2008","unstructured":"Honegger B (2008) Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol 7(3):10","journal-title":"J Biol"},{"key":"6_CR46","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/bs.ctdb.2016.07.013","volume-title":"Current topics in developmental biology","author":"SX Hou","year":"2017","unstructured":"Hou SX, Singh SR (2017) Stem-cell-based tumorigenesis in adult Drosophila. In: Pick L (ed) Current topics in developmental biology, vol 121. Academic, pp 311\u2013337. https:\/\/doi.org\/10.1016\/bs.ctdb.2016.07.013. (Fly Models of Human Diseases). https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0070215316301545"},{"issue":"1","key":"6_CR47","doi-asserted-by":"publisher","first-page":"7150","DOI":"10.1038\/s41467-021-27384-4","volume":"12","author":"DJ-K Hu","year":"2021","unstructured":"Hu DJ-K, Yun J, Elstrott J, Jasper H (2021) Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury. Nat Commun 12(1):7150. https:\/\/doi.org\/10.1038\/s41467-021-27384-4","journal-title":"Nat Commun"},{"key":"6_CR48","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13046-016-0317-z","volume":"35","author":"XY Huang","year":"2016","unstructured":"Huang XY (2016) Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting. J Exp Clin Cancer Res 35:46","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"6_CR49","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.200109065","volume":"156","author":"AM Hudson","year":"2002","unstructured":"Hudson AM, Cooley L (2002) A subset of dynamic actin rearrangements in Drosophila requires the Arp2\/3 complex. J Cell Biol 156(4):677\u2013687. https:\/\/doi.org\/10.1083\/jcb.200109065","journal-title":"J Cell Biol"},{"issue":"3","key":"6_CR50","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1073\/pnas.1916820117","volume":"117","author":"R-J Hung","year":"2020","unstructured":"Hung R-J, Hu Y, Kirchner R, Liu Y, Xu C, Comjean A, Tattikota SG, Li F, Song W, Ho Sui S et al (2020) A cell atlas of the adult Drosophila midgut. Proc Natl Acad Sci 117(3):1514\u20131523. https:\/\/doi.org\/10.1073\/pnas.1916820117","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"6_CR51","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.026955","volume":"136","author":"H Jiang","year":"2009","unstructured":"Jiang H, Edgar BA (2009) EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136(3):483\u2013493. https:\/\/doi.org\/10.1242\/dev.026955","journal-title":"Development"},{"issue":"19","key":"6_CR52","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1016\/j.yexcr.2011.07.020","volume":"317","author":"H Jiang","year":"2011","unstructured":"Jiang H, Edgar BA (2011) Intestinal stem cells in the adult Drosophila midgut. Exp Cell Res 317(19):2780\u20132788. https:\/\/doi.org\/10.1016\/j.yexcr.2011.07.020. (Special Issue - Gastroenterology)","journal-title":"Exp Cell Res"},{"issue":"7","key":"6_CR53","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","volume":"137","author":"H Jiang","year":"2009","unstructured":"Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA (2009) Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137(7):1343\u20131355. https:\/\/doi.org\/10.1016\/j.cell.2009.05.014","journal-title":"Cell"},{"issue":"1","key":"6_CR54","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.stem.2010.11.026","volume":"8","author":"H Jiang","year":"2011","unstructured":"Jiang H, Grenley MO, Bravo M-J, Blumhagen RZ, Edgar BA (2011) EGFR\/Ras\/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8(1):84\u201395. https:\/\/doi.org\/10.1016\/j.stem.2010.11.026","journal-title":"Cell Stem Cell"},{"issue":"17","key":"6_CR55","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1007\/s00018-016-2235-9","volume":"73","author":"H Jiang","year":"2016","unstructured":"Jiang H, Tian A, Jiang J (2016) Intestinal stem cell response to injury: lessons from Drosophila. Cell Mol Life Sci 73(17):3337\u20133349. https:\/\/doi.org\/10.1007\/s00018-016-2235-9","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"6_CR56","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ccr.2013.04.017","volume":"23","author":"Y Kang","year":"2013","unstructured":"Kang Y, Pantel K (2013) Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell 23(5):573\u2013581. https:\/\/doi.org\/10.1016\/j.ccr.2013.04.017","journal-title":"Cancer Cell"},{"issue":"11","key":"6_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003045","volume":"8","author":"S Kapuria","year":"2012","unstructured":"Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H (2012) Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet 8(11):e1003045. https:\/\/doi.org\/10.1371\/journal.pgen.1003045","journal-title":"PLoS Genet"},{"issue":"24","key":"6_CR58","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1242\/dev.060483","volume":"137","author":"P Karpowicz","year":"2010","unstructured":"Karpowicz P, Perez J, Perrimon N (2010) The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 137(24):4135\u20134145. https:\/\/doi.org\/10.1242\/dev.060483","journal-title":"Development"},{"issue":"19","key":"6_CR59","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1016\/j.devcel.2021.08.010","volume":"56","author":"J Kim","year":"2021","unstructured":"Kim J (2021) Tumor-induced disruption of the blood-brain barrier promotes host death. Dev Cell 56(19):2712\u20132721 4","journal-title":"Dev Cell"},{"issue":"1","key":"6_CR60","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41467-020-16164-1","volume":"11","author":"N Kim","year":"2020","unstructured":"Kim N, Kim HK, Lee K, Hong Y, Cho JH, Choi JW, Lee J-I, Suh Y-L, Ku BM, Eum HH et al (2020) Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun 11(1):2285. https:\/\/doi.org\/10.1038\/s41467-020-16164-1","journal-title":"Nat Commun"},{"issue":"1\u20132","key":"6_CR61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0925-4773(00)00328-2","volume":"95","author":"R Klapper","year":"2000","unstructured":"Klapper R (2000) The longitudinal visceral musculature of Drosophila melanogaster persists through metamorphosis. Mech Dev 95(1\u20132):47\u201354. https:\/\/doi.org\/10.1016\/S0925-4773(00)00328-2","journal-title":"Mech Dev"},{"issue":"1","key":"6_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000567","volume":"18","author":"LAJ Koyama","year":"2020","unstructured":"Koyama LAJ, Aranda-D\u00edaz A, Su Y-H, Balachandra S, Martin JL, Ludington WB, Huang KC, O\u2019Brien LE (2020) Bellymount enables longitudinal, intravital imaging of abdominal organs and the gut microbiota in adult Drosophila. PLoS Biol 18(1):e3000567. https:\/\/doi.org\/10.1371\/journal.pbio.3000567","journal-title":"PLoS Biol"},{"key":"6_CR63","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/bs.ctdb.2016.07.003","volume":"121","author":"RE Kreipke","year":"2017","unstructured":"Kreipke RE (2017) Drosophila melanogaster as a model of muscle degeneration disorders. Curr Top Dev Biol 121:83\u2013109","journal-title":"Curr Top Dev Biol"},{"key":"6_CR64","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2024.09.005","volume":"517","author":"R Kumar","year":"2024","unstructured":"Kumar R, Srikrishna S (2024) JNK Kinase regulates cachexia like syndrome in scribble knockdown tumor model of Drosophila melanogaster. Dev Biol 517:28\u201338","journal-title":"Dev Biol"},{"issue":"6159","key":"6_CR65","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1126\/science.1243971","volume":"342","author":"Y Kwon","year":"2013","unstructured":"Kwon Y (2013) The Hippo signaling pathway interactome. Science 342(6159):737\u2013740","journal-title":"Science"},{"issue":"1","key":"6_CR66","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.devcel.2015.02.012","volume":"33","author":"Y Kwon","year":"2015","unstructured":"Kwon Y (2015) Systemic organ wasting induced by localized expression of the secreted insulin\/IGF antagonist ImpL2. Dev Cell 33(1):36\u201346","journal-title":"Dev Cell"},{"issue":"12","key":"6_CR67","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41556-018-0236-7","volume":"20","author":"DA Lawson","year":"2018","unstructured":"Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z (2018) Tumour heterogeneity and metastasis at single-cell resolution. Nat Cell Biol 20(12):1349\u20131360. https:\/\/doi.org\/10.1038\/s41556-018-0236-7","journal-title":"Nat Cell Biol"},{"issue":"23","key":"6_CR68","doi-asserted-by":"publisher","first-page":"e2020120118","DOI":"10.1073\/pnas.2020120118","volume":"118","author":"J Lee","year":"2021","unstructured":"Lee J (2021) Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt\/Wingless. Proc Natl Acad Sci USA 118(23):e2020120118","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"6_CR69","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1242\/dev.035196","volume":"136","author":"W-C Lee","year":"2009","unstructured":"Lee W-C, Beebe K, Sudmeier L, Micchelli CA (2009) Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 136(13):2255\u20132264. https:\/\/doi.org\/10.1242\/dev.035196","journal-title":"Development"},{"issue":"1","key":"6_CR70","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1038\/s41467-020-17341-y","volume":"11","author":"J Lee","year":"2020","unstructured":"Lee J, Cabrera AJH, Nguyen CMT, Kwon YV (2020) Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo. Nat Commun 11(1):3568. https:\/\/doi.org\/10.1038\/s41467-020-17341-y","journal-title":"Nat Commun"},{"issue":"15","key":"6_CR71","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1016\/j.cub.2024.07.021","volume":"34","author":"NY Leung","year":"2024","unstructured":"Leung NY (2024) Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Curr Biol 34(15):3591","journal-title":"Curr Biol"},{"issue":"6","key":"6_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101080","volume":"11","author":"L Li","year":"2024","unstructured":"Li L (2024) A comprehensive review of animal models for cancer cachexia: implications for translational research. Genes Dis 11(6):101080","journal-title":"Genes Dis"},{"issue":"4","key":"6_CR73","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.devcel.2018.04.014","volume":"45","author":"Q Li","year":"2018","unstructured":"Li Q, Nirala NK, Nie Y, Chen H-J, Ostroff G, Mao J, Wang Q, Xu L, Ip YT (2018) Ingestion of food particles regulates the Mechanosensing Misshapen-Yorkie pathway in Drosophila intestinal growth. Dev Cell 45(4):433\u2013449.e6. https:\/\/doi.org\/10.1016\/j.devcel.2018.04.014","journal-title":"Dev Cell"},{"issue":"6","key":"6_CR74","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.celrep.2020.01.041","volume":"30","author":"Z Li","year":"2020","unstructured":"Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T et al (2020) A switch in tissue stem cell identity causes neuroendocrine tumors in Drosophila gut. Cell Rep 30(6):1724\u20131734.e4. https:\/\/doi.org\/10.1016\/j.celrep.2020.01.041","journal-title":"Cell Rep"},{"issue":"4","key":"6_CR75","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.smhs.2020.10.003","volume":"2","author":"S Lim","year":"2020","unstructured":"Lim S (2020) Development and progression of cancer cachexia: perspectives from bench to bedside. Sports Med Health Sci 2(4):177\u2013185","journal-title":"Sports Med Health Sci"},{"issue":"7216","key":"6_CR76","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature07329","volume":"455","author":"G Lin","year":"2008","unstructured":"Lin G, Xu N, Xi R (2008) Paracrine wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455(7216):1119\u20131123. https:\/\/doi.org\/10.1038\/nature07329","journal-title":"Nature"},{"key":"6_CR77","doi-asserted-by":"crossref","unstructured":"Liu Y (2023) Tumor cytokine-induced hepatic gluconeogenesis contributes to cancer cachexia: insights from full body single nuclei sequencing. bioRxiv","DOI":"10.1101\/2023.05.15.540823"},{"issue":"3","key":"6_CR78","doi-asserted-by":"publisher","first-page":"dmm049513","DOI":"10.1242\/dmm.049298","volume":"15","author":"Y Liu","year":"2022","unstructured":"Liu Y, Saavedra P, Perrimon N (2022) Cancer cachexia: lessons from Drosophila. Dis Model Mech 15(3):dmm049513","journal-title":"Dis Model Mech"},{"issue":"2","key":"6_CR79","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/ncb2404","volume":"14","author":"J Maltzahn","year":"2011","unstructured":"Maltzahn J, Bentzinger CF, Rudnicki MA (2011) Wnt7a-Fzd7 signalling directly activates the Akt\/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol 14(2):186\u2013191","journal-title":"Nat Cell Biol"},{"key":"6_CR80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76010","volume":"11","author":"M Marchetti","year":"2022","unstructured":"Marchetti M, Zhang C, Edgar BA (2022) An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine. elife 11:e76010. https:\/\/doi.org\/10.7554\/eLife.76010","journal-title":"elife"},{"issue":"23","key":"6_CR81","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.3390\/cancers15235590","volume":"15","author":"CR Mariean","year":"2023","unstructured":"Mariean CR (2023) Cancer cachexia: new insights and future directions. Cancers (Basel) 15(23):5590","journal-title":"Cancers (Basel)"},{"key":"6_CR82","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36248","volume":"7","author":"JL Martin","year":"2018","unstructured":"Martin JL, Sanders EN, Moreno-Roman P, Jaramillo Koyama LA, Balachandra S, Du X, O\u2019Brien LE (2018) Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss Spradling AC, Morrison SJ, editors. elife 7:e36248. https:\/\/doi.org\/10.7554\/eLife.36248","journal-title":"elife"},{"issue":"2","key":"6_CR83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088413","volume":"9","author":"\u00d2 Martorell","year":"2014","unstructured":"Martorell \u00d2, Merlos-Su\u00e1rez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J, Casali A (2014) Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. PLoS One 9(2):e88413. https:\/\/doi.org\/10.1371\/journal.pone.0088413","journal-title":"PLoS One"},{"issue":"1","key":"6_CR84","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/dvdy.22759","volume":"241","author":"CA Micchelli","year":"2012","unstructured":"Micchelli CA (2012) The origin of intestinal stem cells in Drosophila. Dev Dyn 241(1):85\u201391. https:\/\/doi.org\/10.1002\/dvdy.22759","journal-title":"Dev Dyn"},{"issue":"7075","key":"6_CR85","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature04371","volume":"439","author":"CA Micchelli","year":"2006","unstructured":"Micchelli CA, Perrimon N (2006) Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439(7075):475\u2013479. https:\/\/doi.org\/10.1038\/nature04371","journal-title":"Nature"},{"issue":"2","key":"6_CR86","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1534\/genetics.118.300224","volume":"210","author":"I Miguel-Aliaga","year":"2018","unstructured":"Miguel-Aliaga I, Jasper H, Lemaitre B (2018) Anatomy and physiology of the digestive tract of Drosophila melanogaster. Genetics 210(2):357\u2013396. https:\/\/doi.org\/10.1534\/genetics.118.300224","journal-title":"Genetics"},{"issue":"5","key":"6_CR87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001635","volume":"20","author":"M Mlih","year":"2022","unstructured":"Mlih M, Karpac J (2022) Integrin\u2013ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium. PLoS Biol 20(5):e3001635. https:\/\/doi.org\/10.1371\/journal.pbio.3001635","journal-title":"PLoS Biol"},{"issue":"3","key":"6_CR88","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1006\/jmbi.1994.1376","volume":"239","author":"NS Morgan","year":"1994","unstructured":"Morgan NS, Skovronsky DM, Artavanis-Tsakonas S, Mooseker MS (1994) The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. J Mol Biol 239(3):347\u2013356. https:\/\/doi.org\/10.1006\/jmbi.1994.1376","journal-title":"J Mol Biol"},{"issue":"2","key":"6_CR89","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/jmor.1025","volume":"248","author":"R Murakami","year":"2001","unstructured":"Murakami R, Shiotsuki Y (2001) Ultrastructure of the hindgut of Drosophila larvae, with special reference to the domains identified by specific gene expression patterns. J Morphol 248(2):144\u2013150. https:\/\/doi.org\/10.1002\/jmor.1025","journal-title":"J Morphol"},{"issue":"8","key":"6_CR90","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.cub.2020.01.082","volume":"30","author":"S Ngo","year":"2020","unstructured":"Ngo S, Liang J, Su Y-H, O\u2019Brien LE (2020) Disruption of EGF feedback by intestinal tumors and neighboring cells in Drosophila. Curr Biol 30(8):1537\u20131546.e3. https:\/\/doi.org\/10.1016\/j.cub.2020.01.082","journal-title":"Curr Biol"},{"issue":"3","key":"6_CR91","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2011.08.048","volume":"147","author":"LE O\u2019Brien","year":"2011","unstructured":"O\u2019Brien LE, Soliman SS, Li X, Bilder D (2011) Altered modes of stem cell division drive adaptive intestinal growth. Cell 147(3):603\u2013614. https:\/\/doi.org\/10.1016\/j.cell.2011.08.048","journal-title":"Cell"},{"issue":"7075","key":"6_CR92","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature04333","volume":"439","author":"B Ohlstein","year":"2006","unstructured":"Ohlstein B, Spradling A (2006) The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439(7075):470\u2013474. https:\/\/doi.org\/10.1038\/nature04333","journal-title":"Nature"},{"issue":"5814","key":"6_CR93","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.1136606","volume":"315","author":"B Ohlstein","year":"2007","unstructured":"Ohlstein B, Spradling A (2007) Multipotent drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 315(5814):988\u2013992. https:\/\/doi.org\/10.1126\/science.1136606","journal-title":"Science"},{"issue":"5648","key":"6_CR94","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1126\/science.1088474","volume":"302","author":"RA Pagliarini","year":"2003","unstructured":"Pagliarini RA, Xu T (2003) A genetic screen in drosophila for metastatic behavior. Science 302(5648):1227\u20131231. https:\/\/doi.org\/10.1126\/science.1088474","journal-title":"Science"},{"issue":"9","key":"6_CR95","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/ncb3214","volume":"17","author":"PH Patel","year":"2015","unstructured":"Patel PH, Dutta D, Edgar BA (2015) Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol 17(9):1182\u20131192. https:\/\/doi.org\/10.1038\/ncb3214","journal-title":"Nat Cell Biol"},{"issue":"21","key":"6_CR96","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1242\/dev.065292","volume":"138","author":"CN Perdigoto","year":"2011","unstructured":"Perdigoto CN, Schweisguth F, Bardin AJ (2011) Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 138(21):4585\u20134595. https:\/\/doi.org\/10.1242\/dev.065292","journal-title":"Development"},{"issue":"5","key":"6_CR97","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/gad.276733.115","volume":"30","author":"M Petruzzelli","year":"2016","unstructured":"Petruzzelli M, Wagner EF (2016) Mechanisms of metabolic dysfunction in cancer-associated cachexia. Genes Dev 30(5):489\u2013501","journal-title":"Genes Dev"},{"issue":"10","key":"6_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113245","volume":"42","author":"IKA Pranoto","year":"2023","unstructured":"Pranoto IKA, Lee J, Kwon YV (2023) The roles of the native cell differentiation program aberrantly recapitulated in Drosophila intestinal tumors. Cell Rep 42(10):113245","journal-title":"Cell Rep"},{"issue":"11","key":"6_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113370","volume":"42","author":"M Quintero","year":"2023","unstructured":"Quintero M, Bangi E (2023) Disruptions in cell fate decisions and transformed enteroendocrine cells drive intestinal tumorigenesis in Drosophila. Cell Rep 42(11):113370","journal-title":"Cell Rep"},{"issue":"1","key":"6_CR100","doi-asserted-by":"publisher","first-page":"11677","DOI":"10.1038\/s41598-017-11199-9","volume":"7","author":"MM Rahman","year":"2017","unstructured":"Rahman MM, Franch-Marro X, Maestro JL, Martin D, Casali A (2017) Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila. Sci Rep 7(1):11677. https:\/\/doi.org\/10.1038\/s41598-017-11199-9","journal-title":"Sci Rep"},{"issue":"49","key":"6_CR101","doi-asserted-by":"publisher","first-page":"21064","DOI":"10.1073\/pnas.1012759107","volume":"107","author":"F Ren","year":"2010","unstructured":"Ren F (2010) Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci USA 107(49):21064\u201321069","journal-title":"Proc Natl Acad Sci USA"},{"key":"6_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4258387","volume":"2018","author":"HE Richardson","year":"2018","unstructured":"Richardson HE, Portela M (2018) Modelling cooperative tumorigenesis in Drosophila. Biomed Res Int 2018:1\u201329. https:\/\/doi.org\/10.1155\/2018\/4258387","journal-title":"Biomed Res Int"},{"issue":"12","key":"6_CR103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008553","volume":"15","author":"SE Rojas Villa","year":"2019","unstructured":"Rojas Villa SE, Meng FW, Biteau B (2019) zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage Teleman AA, editor. PLoS Genet 15(12):e1008553. https:\/\/doi.org\/10.1371\/journal.pgen.1008553","journal-title":"PLoS Genet"},{"key":"6_CR104","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-3-030-23629-8_11","volume":"1167","author":"P Saavedra","year":"2019","unstructured":"Saavedra P, Perrimon N (2019) Drosophila as a model for tumor-induced organ wasting. Adv Exp Med Biol 1167:191\u2013205","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"6_CR105","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.molonc.2013.02.009","volume":"7","author":"M Saxena","year":"2013","unstructured":"Saxena M, Christofori G (2013) Rebuilding cancer metastasis in the mouse. Mol Oncol 7(2):283\u2013296. https:\/\/doi.org\/10.1016\/j.molonc.2013.02.009","journal-title":"Mol Oncol"},{"issue":"2","key":"6_CR106","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cmet.2018.09.021","volume":"29","author":"A Scopelliti","year":"2019","unstructured":"Scopelliti A (2019) A neuronal relay mediates a nutrient responsive gut\/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metab 29(2):269\u2013284 10","journal-title":"Cell Metab"},{"issue":"11","key":"6_CR107","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.cub.2014.04.007","volume":"24","author":"A Scopelliti","year":"2014","unstructured":"Scopelliti A, Cordero JB, Diao F, Strathdee K, White BH, Sansom OJ, Vidal M (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr Biol 24(11):1199\u20131211. https:\/\/doi.org\/10.1016\/j.cub.2014.04.007","journal-title":"Curr Biol"},{"issue":"5","key":"6_CR108","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/cells12050677","volume":"12","author":"JL Sharpe","year":"2023","unstructured":"Sharpe JL, Morgan J, Nisbet N, Campbell K, Casali A (2023) Modelling cancer metastasis in Drosophila melanogaster. Cells 12(5):677. https:\/\/doi.org\/10.3390\/cells12050677","journal-title":"Cells"},{"issue":"2","key":"6_CR109","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.devcel.2018.12.003","volume":"48","author":"W Song","year":"2019","unstructured":"Song W (2019) Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation. Dev Cell 48(2):277\u2013286 6","journal-title":"Dev Cell"},{"issue":"17","key":"6_CR110","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.cub.2010.07.041","volume":"20","author":"BK Staley","year":"2010","unstructured":"Staley BK, Irvine KD (2010) Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr Biol 20(17):1580\u20131587. https:\/\/doi.org\/10.1016\/j.cub.2010.07.041","journal-title":"Curr Biol"},{"issue":"7204","key":"6_CR111","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature07156","volume":"454","author":"S Takashima","year":"2008","unstructured":"Takashima S, Mkrtchyan M, Younossi-Hartenstein A, Merriam JR, Hartenstein V (2008) The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature 454(7204):651\u2013655. https:\/\/doi.org\/10.1038\/nature07156","journal-title":"Nature"},{"issue":"9","key":"6_CR112","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1242\/dev.082933","volume":"140","author":"S Takashima","year":"2013","unstructured":"Takashima S, Paul M, Aghajanian P, Younossi-Hartenstein A, Hartenstein V (2013) Migration of Drosophila intestinal stem cells across organ boundaries. Development 140(9):1903\u20131911. https:\/\/doi.org\/10.1242\/dev.082933","journal-title":"Development"},{"key":"6_CR113","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s42003-021-02757-z","volume":"4","author":"R Tang","year":"2021","unstructured":"Tang R, Qin P, Liu X, Wu S, Yao R, Cai G, Gao J, Wu Y, Guo Z (2021) Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Commun Biol 4:1223. https:\/\/doi.org\/10.1038\/s42003-021-02757-z","journal-title":"Commun Biol"},{"issue":"7","key":"6_CR114","doi-asserted-by":"publisher","first-page":"1006870","DOI":"10.1371\/journal.pgen.1006870","volume":"13","author":"A Tian","year":"2017","unstructured":"Tian A (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genet 13(7):1006870","journal-title":"PLoS Genet"},{"key":"6_CR115","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01857","volume":"3","author":"A Tian","year":"2014","unstructured":"Tian A, Jiang J (2014) Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut Banerjee U, editor. elife 3:e01857. https:\/\/doi.org\/10.7554\/eLife.01857","journal-title":"elife"},{"issue":"2","key":"6_CR116","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/jdb6020008","volume":"6","author":"A Tian","year":"2018","unstructured":"Tian A, Benchabane H, Ahmed Y (2018) Wingless\/Wnt signaling in intestinal development, homeostasis, regeneration and tumorigenesis: a Drosophila perspective. J Dev Biol 6(2):8. https:\/\/doi.org\/10.3390\/jdb6020008","journal-title":"J Dev Biol"},{"issue":"19","key":"6_CR117","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022110834","volume":"41","author":"A Tian","year":"2022","unstructured":"Tian A, Morejon V, Kohoutek S, Huang Y, Deng W, Jiang J (2022) Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut. EMBO J 41(19):e110834. https:\/\/doi.org\/10.15252\/embj.2022110834","journal-title":"EMBO J"},{"issue":"1","key":"6_CR118","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1038\/s41467-019-10926-2","volume":"10","author":"X Tracy Cai","year":"2019","unstructured":"Tracy Cai X, Li H, Safyan A, Gawlik J, Pyrowolakis G, Jasper H (2019) AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis. Nat Commun 10(1):2988. https:\/\/doi.org\/10.1038\/s41467-019-10926-2","journal-title":"Nat Commun"},{"issue":"7553","key":"6_CR119","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/521430a","volume":"521","author":"EF Wagner","year":"2015","unstructured":"Wagner EF, Petruzzelli M (2015) Cancer metabolism: a waste of insulin interference. Nature 521(7553):430\u2013431","journal-title":"Nature"},{"issue":"8","key":"6_CR120","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1097\/CM9.0000000000002628","volume":"136","author":"X Wang","year":"2023","unstructured":"Wang X (2023) IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor\/insulin signaling. Chin Med J 136(8):974\u2013985","journal-title":"Chin Med J"},{"issue":"2","key":"6_CR121","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ydbio.2013.03.020","volume":"378","author":"C Wang","year":"2013","unstructured":"Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R (2013) APC loss-induced intestinal tumorigenesis in Drosophila: roles of Ras in Wnt signaling activation and tumor progression. Dev Biol 378(2):122\u2013140. https:\/\/doi.org\/10.1016\/j.ydbio.2013.03.020","journal-title":"Dev Biol"},{"issue":"12","key":"6_CR122","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/ncb1998","volume":"11","author":"U Wellner","year":"2009","unstructured":"Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, zur Hausen A et al (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11(12):1487\u20131495. https:\/\/doi.org\/10.1038\/ncb1998","journal-title":"Nat Cell Biol"},{"issue":"7280","key":"6_CR123","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature08702","volume":"463","author":"M Wu","year":"2010","unstructured":"Wu M, Pastor-Pareja JC, Xu T (2010) Interaction between RasV12 and scribbled clones induces tumour growth and invasion. Nature 463(7280):545\u2013548. https:\/\/doi.org\/10.1038\/nature08702","journal-title":"Nature"},{"issue":"1","key":"6_CR124","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1038\/s41467-021-22801-0","volume":"12","author":"F Wu","year":"2021","unstructured":"Wu F, Fan J, He Y, Xiong A, Yu J, Li Y, Zhang Y, Zhao W, Zhou F, Li W et al (2021) Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat Commun 12(1):2540. https:\/\/doi.org\/10.1038\/s41467-021-22801-0","journal-title":"Nat Commun"},{"issue":"7991","key":"6_CR125","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41586-023-06833-8","volume":"624","author":"W Xu","year":"2023","unstructured":"Xu W (2023) A novel antidiuretic hormone governs tumour-induced renal dysfunction. Nature 624(7991):425\u2013432","journal-title":"Nature"},{"issue":"1","key":"6_CR126","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/s41467-024-45493-8","volume":"15","author":"J Xu","year":"2024","unstructured":"Xu J (2024) Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome. Nat Commun 15(1):1241","journal-title":"Nat Commun"},{"key":"6_CR127","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58810","volume":"9","author":"SK Yeo","year":"2020","unstructured":"Yeo SK, Zhu X, Okamoto T, Hao M, Wang C, Lu P, Lu LJ, Guan J-L (2020) Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer Zwart W, Murphy ME, Zwart W, Magnani L, Natrajan R, editors. elife 9:e58810. https:\/\/doi.org\/10.7554\/eLife.58810","journal-title":"elife"},{"issue":"4","key":"6_CR128","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1242\/dev.113357","volume":"142","author":"X Zeng","year":"2015","unstructured":"Zeng X, Hou SX (2015) Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut. Development 142(4):644\u2013653. https:\/\/doi.org\/10.1242\/dev.113357","journal-title":"Development"},{"issue":"10","key":"6_CR129","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/dvg.20661","volume":"48","author":"X Zeng","year":"2010","unstructured":"Zeng X, Chauhan C, Hou SX (2010) Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila. Genesis (New York, N.Y.: 2000) 48(10):607\u2013611. https:\/\/doi.org\/10.1002\/dvg.20661","journal-title":"Genesis (New York, N.Y.: 2000)"},{"key":"6_CR130","doi-asserted-by":"publisher","first-page":"10219","DOI":"10.1038\/ncomms10219","volume":"6","author":"Z Zhai","year":"2015","unstructured":"Zhai Z (2015) Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat Commun 6:10219","journal-title":"Nat Commun"},{"key":"6_CR131","doi-asserted-by":"publisher","first-page":"a040915","DOI":"10.1101\/cshperspect.a040915","volume":"14","author":"P Zhang","year":"2022","unstructured":"Zhang P, Edgar BA (2022) Insect gut regeneration. Cold Spring Harb Perspect Biol 14:a040915","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"6_CR132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2024.104114","volume":"168","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wang Y, Wang L, Zhang Y, Xing X, Zhao Z, Dong W, Moussian B, Zhang J (2024a) Determination of the larval precursor configuration of the Drosophila adult hindgut by G-TRACE analysis. Insect Biochem Mol Biol 168:104114. https:\/\/doi.org\/10.1016\/j.ibmb.2024.104114","journal-title":"Insect Biochem Mol Biol"},{"issue":"1","key":"6_CR133","doi-asserted-by":"publisher","first-page":"5493","DOI":"10.1038\/s41467-024-49786-w","volume":"15","author":"P Zhang","year":"2024","unstructured":"Zhang P, Pronovost SM, Marchetti M, Zhang C, Kang X, Kandelouei T, Li C, Edgar BA (2024b) Inter-cell type interactions that control JNK signaling in the Drosophila intestine. Nat Commun 15(1):5493. https:\/\/doi.org\/10.1038\/s41467-024-49786-w","journal-title":"Nat Commun"}],"container-title":["Advances in Experimental Medicine and Biology","The Drosophila Model in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-031-97035-1_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T11:06:44Z","timestamp":1780830404000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-031-97035-1_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783031970344","9783031970351"],"references-count":133,"URL":"https:\/\/doi.org\/10.1007\/978-3-031-97035-1_6","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"1 August 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}