{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:23:18Z","timestamp":1761913398062,"version":"build-2065373602"},"publisher-location":"Cham","reference-count":16,"publisher":"Springer Nature Switzerland","isbn-type":[{"type":"print","value":"9783032024886"},{"type":"electronic","value":"9783032024893"}],"license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-02489-3_13","type":"book-chapter","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:17:12Z","timestamp":1761913032000},"page":"171-182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug-Centric Prior Improves Drug Response Modeling in\u00a0Partially Overlapping Pharmacogenomic Screens"],"prefix":"10.1007","author":[{"given":"Dharani","family":"Thirumalaisamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Q.","family":"Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Tyner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"G\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"issue":"7391","key":"13_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","volume":"483","author":"J Barretina","year":"2012","unstructured":"Barretina, J., et al.: The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391), 603\u2013607 (2012)","journal-title":"Nature"},{"issue":"1","key":"13_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman, H.M., et al.: The protein data bank. Nucleic Acids Res. 28(1), 235\u2013242 (2000)","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"13_CR3","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nm.2344","volume":"17","author":"EA Collisson","year":"2011","unstructured":"Collisson, E.A., et al.: Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17(4), 500\u2013503 (2011)","journal-title":"Nat. Med."},{"key":"13_CR4","doi-asserted-by":"crossref","unstructured":"Cancer Cell Line Encyclopedia Consortium Broad Institute: Pharmacogenomic agreement between two cancer cell line data sets. Nature 528(7580), 84\u201387 (2015)","DOI":"10.1038\/nature15736"},{"key":"13_CR5","doi-asserted-by":"crossref","unstructured":"Deng, Y., et al.: Mek inhibitor mirdametinib suppresses map kinase pathway activity and inhibits tumor growth in atypical teratoid\/rhabdoid tumors. Cancer Res. 84(6_Supplement), 6498\u20136498 (2024)","DOI":"10.1158\/1538-7445.AM2024-6498"},{"issue":"6","key":"13_CR6","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1517\/13543780902953699","volume":"18","author":"C Erlichman","year":"2009","unstructured":"Erlichman, C.: Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin. Investig. Drugs 18(6), 861\u2013868 (2009)","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"7391","key":"13_CR7","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nature11005","volume":"483","author":"MJ Garnett","year":"2012","unstructured":"Garnett, M.J., et al.: Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483(7391), 570\u2013575 (2012)","journal-title":"Nature"},{"issue":"7480","key":"13_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature12831","volume":"504","author":"B Haibe-Kains","year":"2013","unstructured":"Haibe-Kains, B., et al.: Inconsistency in large pharmacogenomic studies. Nature 504(7480), 389\u2013393 (2013)","journal-title":"Nature"},{"issue":"3","key":"13_CR9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/onc.2010.408","volume":"30","author":"F Kaplan","year":"2011","unstructured":"Kaplan, F., Shao, Y., Mayberry, M., Aplin, A.: Hyperactivation of mek-erk1\/2 signaling and resistance to apoptosis induced by the oncogenic b-raf inhibitor, plx4720, in mutant n-ras melanoma cells. Oncogene 30(3), 366\u2013371 (2011)","journal-title":"Oncogene"},{"issue":"3","key":"13_CR10","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1182\/blood-2005-12-5148","volume":"108","author":"K Kojima","year":"2006","unstructured":"Kojima, K., Konopleva, M., McQueen, T., O\u2019Brien, S., Plunkett, W., Andreeff, M.: Mdm2 inhibitor nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome ATM-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108(3), 993\u20131000 (2006)","journal-title":"Blood"},{"issue":"15","key":"13_CR11","doi-asserted-by":"publisher","first-page":"5132","DOI":"10.1158\/1078-0432.CCR-11-0072","volume":"17","author":"S Modi","year":"2011","unstructured":"Modi, S., et al.: Hsp90 inhibition is effective in breast cancer: a phase ii trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin. Cancer Res. 17(15), 5132\u20135139 (2011)","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"13_CR12","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1093\/bioinformatics\/btw836","volume":"33","author":"O Nikolova","year":"2017","unstructured":"Nikolova, O., Moser, R., Kemp, C., G\u00f6nen, M., Margolin, A.A.: Modeling gene-wise dependencies improves the identification of drug response biomarkers in cancer studies. Bioinformatics 33(9), 1362\u20131369 (2017)","journal-title":"Bioinformatics"},{"issue":"1","key":"13_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrd705","volume":"1","author":"DM Roden","year":"2002","unstructured":"Roden, D.M., George, A.L., Jr.: The genetic basis of variability in drug responses. Nat. Rev. Drug Discovery 1(1), 37\u201344 (2002)","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"6","key":"13_CR14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.2174\/138161211795222586","volume":"17","author":"P Secchiero","year":"2011","unstructured":"Secchiero, P., Bosco, R., Celeghini, C., Zauli, G.: Recent advances in the therapeutic perspectives of nutlin-3. Curr. Pharm. Des. 17(6), 569\u2013577 (2011)","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"13_CR15","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1158\/1078-0432.CCR-06-1150","volume":"13","author":"TC Yeh","year":"2007","unstructured":"Yeh, T.C., et al.: Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1\/2 inhibitor. Clin. Cancer Res. 13(5), 1576\u20131583 (2007)","journal-title":"Clin. Cancer Res."},{"issue":"D1","key":"13_CR16","doi-asserted-by":"publisher","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","volume":"52","author":"Y Zhou","year":"2024","unstructured":"Zhou, Y., et al.: TTD: therapeutic target database describing target druggability information. Nucleic Acids Res. 52(D1), D1465\u2013D1477 (2024)","journal-title":"Nucleic Acids Res."}],"container-title":["Lecture Notes in Computer Science","Computational Advances in Bio and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-02489-3_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:17:16Z","timestamp":1761913036000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-02489-3_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"ISBN":["9783032024886","9783032024893"],"references-count":16,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-02489-3_13","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"1 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"No competing interest is declared.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of Interests"}},{"value":"ICCABS","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Computational Advances in Bio and Medical Sciences","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Atlanta, GA","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"USA","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2025","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"12 January 2025","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"14 January 2025","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"13","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"iccabs2025","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/sites.google.com\/view\/iccabs-2025\/home","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}