{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:05:49Z","timestamp":1784297149709,"version":"3.55.0"},"publisher-location":"Cham","reference-count":80,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032031754","type":"print"},{"value":"9783032031761","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03176-1_16","type":"book-chapter","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:48:44Z","timestamp":1762984124000},"page":"317-334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammasomes in Oral Pathologies: From Periodontal Disease to Oral Cancer"],"prefix":"10.1007","author":[{"given":"Gaetano","family":"Isola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Polizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"1","key":"16_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","volume":"86","author":"L Abusleme","year":"2021","unstructured":"Abusleme L, Hoare A, Hong BY, Diaz PI (2021) Microbial signatures of health, gingivitis, and periodontitis. Periodontol 86(1):57\u201378","journal-title":"Periodontol"},{"issue":"4","key":"16_CR2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783\u2013801","journal-title":"Cell"},{"key":"16_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115693","volume":"215","author":"J Bockstiegel","year":"2023","unstructured":"Bockstiegel J, Wurnig SL, Engelhardt J, Enns J, Hansen FK, Weindl G (2023) Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1beta release. Biochem Pharmacol 215:115693. https:\/\/doi.org\/10.1016\/j.bcp.2023.115693","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"16_CR4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2249.2009.03972.x","volume":"157","author":"N Bostanci","year":"2009","unstructured":"Bostanci N, Emingil G, Saygan B, Turkoglu O, Atilla G, Curtis MA, Belibasakis GN (2009) Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. Clin Exp Immunol 157(3):415\u2013422. https:\/\/doi.org\/10.1111\/j.1365-2249.2009.03972.x","journal-title":"Clin Exp Immunol"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/978-3-319-89390-7_7","volume-title":"Inflammasomes: clinical and therapeutic implications","author":"P Bullon","year":"2018","unstructured":"Bullon P, Pavillard LE, de la Torre-Torres R (2018) Inflammasome and oral diseases. In: Inflammasomes: clinical and therapeutic implications, pp 153\u2013176"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3389\/fphar.2018.01157","volume":"9","author":"G Cavalli","year":"2018","unstructured":"Cavalli G, Dinarello CA (2018) Anakinra therapy for non-cancer inflammatory diseases. Front Pharmacol 9:1157. https:\/\/doi.org\/10.3389\/fphar.2018.01157","journal-title":"Front Pharmacol"},{"key":"16_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105451","volume":"121","author":"A Chamoli","year":"2021","unstructured":"Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A (2021) Overview of oral cavity squamous cell carcinoma: risk factors, mechanisms, and diagnostics. Oral Oncol 121:105451. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105451","journal-title":"Oral Oncol"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1002\/JPER.17-0719","volume":"89","author":"IL Chapple","year":"2018","unstructured":"Chapple IL, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M (2018) Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions. J Periodontol 89:S74\u2013S84","journal-title":"J Periodontol"},{"issue":"2","key":"16_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12973","volume":"54","author":"Y Chen","year":"2021","unstructured":"Chen Y, Yang Q, Lv C, Chen Y, Zhao W, Li W, Chen H, Wang H, Sun W, Yuan H (2021) NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. Cell Prolif 54(2):e12973","journal-title":"Cell Prolif"},{"issue":"1","key":"16_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1601-0825.2011.01846.x","volume":"18","author":"M Chu","year":"2012","unstructured":"Chu M, Su YX, Wang L, Zhang TH, Liang YJ, Liang LZ, Liao GQ (2012) Myeloid-derived suppressor cells contribute to oral cancer progression in 4NQO-treated mice. Oral Dis 18(1):67\u201373. https:\/\/doi.org\/10.1111\/j.1601-0825.2011.01846.x","journal-title":"Oral Dis"},{"issue":"3","key":"16_CR11","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1124\/pharmrev.120.000171","volume":"73","author":"SE Corcoran","year":"2021","unstructured":"Corcoran SE, Halai R, Cooper MA (2021) Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 Inflammasome with MCC950. Pharmacol Rev 73(3):968\u20131000. https:\/\/doi.org\/10.1124\/pharmrev.120.000171","journal-title":"Pharmacol Rev"},{"key":"16_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.617485","volume":"12","author":"C Cugini","year":"2021","unstructured":"Cugini C, Ramasubbu N, Tsiagbe VK, Fine DH (2021) Dysbiosis from a microbial and host perspective relative to Oral health and disease. Front Microbiol 12:617485. https:\/\/doi.org\/10.3389\/fmicb.2021.617485","journal-title":"Front Microbiol"},{"issue":"1","key":"16_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227905","volume":"15","author":"JB de Alencar","year":"2020","unstructured":"de Alencar JB, Zacarias JMV, Tsuneto PY, Souza VH, Silva COE, Visentainer JEL, Sell AM (2020) Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility. PLoS One 15(1):e0227905. https:\/\/doi.org\/10.1371\/journal.pone.0227905","journal-title":"PLoS One"},{"issue":"12","key":"16_CR14","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1002\/jemt.23101","volume":"81","author":"RS de Molon","year":"2018","unstructured":"de Molon RS, Park CH, Jin Q, Sugai J, Cirelli JA (2018) Characterization of ligature-induced experimental periodontitis. Microsc Res Tech 81(12):1412\u20131421. https:\/\/doi.org\/10.1002\/jemt.23101","journal-title":"Microsc Res Tech"},{"issue":"1","key":"16_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/omi.12121","volume":"31","author":"JL Ebersole","year":"2016","unstructured":"Ebersole JL, Kirakodu S, Novak MJ, Exposto CR, Stromberg AJ, Shen S, Orraca L, Gonzalez-Martinez J, Gonzalez OA (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31(1):18\u201332","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"16_CR16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13046-017-0553-x","volume":"36","author":"X Feng","year":"2017","unstructured":"Feng X, Luo Q, Zhang H, Wang H, Chen W, Meng G, Chen F (2017) The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma. J Exp Clin Cancer Res 36(1):81. https:\/\/doi.org\/10.1186\/s13046-017-0553-x","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"16_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3760\/cma.j.issn.1002-0098.2018.04.007","volume":"53","author":"J Fu","year":"2018","unstructured":"Fu J, Su Y, Liu Y, Zhang XY (2018) Comparative analysis of methylation profiles in tissues of oral leukoplakia and oral squamous cell carcinoma. Zhonghua Kou Qiang Yi Xue Za Zhi 53(4):248\u2013253. https:\/\/doi.org\/10.3760\/cma.j.issn.1002-0098.2018.04.007","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"16_CR18","volume-title":"The relationship between Oral health and systemic disease","author":"JR Gurenlian","year":"2009","unstructured":"Gurenlian JR (2009) The relationship between Oral health and systemic disease. The Dental Assistance"},{"issue":"1","key":"16_CR19","doi-asserted-by":"publisher","first-page":"14488","DOI":"10.1038\/srep14488","volume":"5","author":"P Gurung","year":"2015","unstructured":"Gurung P, Li B, Subbarao Malireddi R, Lamkanfi M, Geiger TL, Kanneganti T-D (2015) Chronic TLR stimulation controls NLRP3 inflammasome activation through IL-10 mediated regulation of NLRP3 expression and caspase-8 activation. Sci Rep 5(1):14488","journal-title":"Sci Rep"},{"issue":"12","key":"16_CR20","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"Y He","year":"2016","unstructured":"He Y, Hara H, N\u00fa\u00f1ez G (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 41(12):1012\u20131021","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"16_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3214","volume":"22","author":"Z He","year":"2020","unstructured":"He Z, Sun Y, Wu J, Xiong Z, Zhang S, Liu J, Liu Y, Li H, Jin T, Yang Y, Yang S (2020) Evaluation of genetic variants in IL-1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population. J Gene Med 22(10):e3214. https:\/\/doi.org\/10.1002\/jgm.3214","journal-title":"J Gene Med"},{"key":"16_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105191","volume":"116","author":"A Herreros-Pomares","year":"2021","unstructured":"Herreros-Pomares A, Llorens C, Soriano B, Bagan L, Moreno A, Calabuig-Fari\u00f1as S, Jantus-Lewintre E, Bagan J (2021) Differentially methylated genes in proliferative verrucous leukoplakia reveal potential malignant biomarkers for oral squamous cell carcinoma. Oral Oncol 116:105191. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105191","journal-title":"Oral Oncol"},{"issue":"1","key":"16_CR23","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13046-017-0589-y","volume":"36","author":"CF Huang","year":"2017","unstructured":"Huang CF, Chen L, Li YC, Wu L, Yu GT, Zhang WF, Sun ZJ (2017) NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma. J Exp Clin Cancer Res 36(1):116. https:\/\/doi.org\/10.1186\/s13046-017-0589-y","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"16_CR24","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/jre.12860","volume":"56","author":"G Isola","year":"2021","unstructured":"Isola G, Polizzi A, Alibrandi A, Williams RC, Lo Giudice A (2021) Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis. J Periodontal Res 56(3):597\u2013605. https:\/\/doi.org\/10.1111\/jre.12860","journal-title":"J Periodontal Res"},{"issue":"1","key":"16_CR25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/JPER.21-0049","volume":"93","author":"G Isola","year":"2022","unstructured":"Isola G, Polizzi A, Santonocito S, Alibrandi A, Williams RC (2022) Periodontitis activates the NLRP3 inflammasome in serum and saliva. J Periodontol 93(1):135\u2013145","journal-title":"J Periodontol"},{"issue":"11","key":"16_CR26","doi-asserted-by":"publisher","first-page":"6855","DOI":"10.1007\/s00784-023-05300-y","volume":"27","author":"G Isola","year":"2023","unstructured":"Isola G, Polizzi A, Mascitti M, Santonocito S, Ronsivalle V, Cicciu M, Pesce P (2023a) Impact of periodontitis on circulating cell-free DNA levels as a measure of cardiovascular disease. Clin Oral Investig 27(11):6855\u20136863. https:\/\/doi.org\/10.1007\/s00784-023-05300-y","journal-title":"Clin Oral Investig"},{"issue":"1","key":"16_CR27","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1186\/s12903-023-03237-y","volume":"23","author":"G Isola","year":"2023","unstructured":"Isola G, Tartaglia GM, Santonocito S, Chaurasia A, Marya A, Lo Giudice A (2023b) Growth differentiation factor-15 and circulating biomarkers as predictors of periodontal treatment effects in patients with periodontitis: a randomized-controlled clinical trial. BMC Oral Health 23(1):582. https:\/\/doi.org\/10.1186\/s12903-023-03237-y","journal-title":"BMC Oral Health"},{"issue":"12","key":"16_CR28","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/JPER.23-0063","volume":"94","author":"G Isola","year":"2023","unstructured":"Isola G, Tartaglia GM, Santonocito S, Polizzi A, Williams RC, Iorio-Siciliano V (2023c) Impact of N-terminal pro-B-type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: an explorative human randomized-controlled clinical trial. J Periodontol 94(12):1414\u20131424. https:\/\/doi.org\/10.1002\/JPER.23-0063","journal-title":"J Periodontol"},{"key":"16_CR29","doi-asserted-by":"publisher","unstructured":"Isola G, Polizzi A, Santonocito S, Alibrandi A, Pesce P, Kocher T (2024) Effect of quadrantwise versus full-mouth subgingival instrumentation on clinical and microbiological parameters in periodontitis patients: A randomized clinical trial. J Periodontal Res 59. https:\/\/doi.org\/10.1111\/jre.13279","DOI":"10.1111\/jre.13279"},{"issue":"1","key":"16_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12105-024-01685-8","volume":"18","author":"T Jain","year":"2024","unstructured":"Jain T, Chandra A, Mishra SP, Khairnar M, Rajoria S, Maheswari R, Keerthika R, Tiwari S, Agrawal R (2024) Unravelling the significance of NLRP3 and IL-\u03b21 in Oral squamous cell carcinoma and potentially malignant Oral disorders: A diagnostic and prognostic exploration. Head Neck Pathol 18(1):77. https:\/\/doi.org\/10.1007\/s12105-024-01685-8","journal-title":"Head Neck Pathol"},{"issue":"4","key":"16_CR31","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1600-0714.1988.tb01515.x","volume":"17","author":"JJ Jandinski","year":"1988","unstructured":"Jandinski JJ (1988) Osteoclast activating factor is now interleukin-1 beta: historical perspective and biological implications. J Oral Pathol 17(4):145\u2013152. https:\/\/doi.org\/10.1111\/j.1600-0714.1988.tb01515.x","journal-title":"J Oral Pathol"},{"issue":"2","key":"16_CR32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cyto.2013.08.011","volume":"64","author":"T Kamatani","year":"2013","unstructured":"Kamatani T, Shiogama S, Yoshihama Y, Kondo S, Shirota T, Shintani S (2013) Interleukin-1 beta in unstimulated whole saliva is a potential biomarker for oral squamous cell carcinoma. Cytokine 64(2):497\u2013502. https:\/\/doi.org\/10.1016\/j.cyto.2013.08.011","journal-title":"Cytokine"},{"issue":"4","key":"16_CR33","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s40496-023-00350-3","volume":"10","author":"S Karaaslan","year":"2023","unstructured":"Karaaslan S (2023) Relationship of NLRP3 Inflammasome with Oral health. Curr Oral Health Rep 10(4):196\u2013202","journal-title":"Curr Oral Health Rep"},{"key":"16_CR34","doi-asserted-by":"publisher","unstructured":"Kelk P, Moghbel NS, Hirschfeld J, Johansson A (2022) Aggregatibacter actinomycetemcomitans Leukotoxin activates the NLRP3 Inflammasome and cell-to-cell communication. Pathogens 11(2). https:\/\/doi.org\/10.3390\/pathogens11020159","DOI":"10.3390\/pathogens11020159"},{"issue":"4","key":"16_CR35","first-page":"1830","volume":"16","author":"Z Khabadze","year":"2023","unstructured":"Khabadze Z, Kulikova A, Generalova Y, Abdulkerimova S, Dashtieva M, Bakaev Y, Shainyan A, Yusupov M, Golovina V, Karapetov K (2023) The prevalence of inflammatory periodontal diseases (gingivitis, periodontitis) among the population. J Int Dental Med Res 16(4):1830\u20131835","journal-title":"J Int Dental Med Res"},{"issue":"11","key":"16_CR36","doi-asserted-by":"publisher","first-page":"11123","DOI":"10.1007\/s11033-022-07894-0","volume":"49","author":"RB Koca-\u00dcnsal","year":"2022","unstructured":"Koca-\u00dcnsal RB, \u015eehirli A\u00d6, Say\u0131ner S, Aksoy U (2022) Relationship of NLRP3 inflammasome with periodontal, endodontic and related systemic diseases. Mol Biol Rep 49(11):11123\u201311132","journal-title":"Mol Biol Rep"},{"key":"16_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.825266","volume":"13","author":"P Kumari","year":"2022","unstructured":"Kumari P, Debta P, Dixit A (2022) Oral potentially malignant disorders: etiology, pathogenesis, and transformation into Oral cancer. Front Pharmacol 13:825266. https:\/\/doi.org\/10.3389\/fphar.2022.825266","journal-title":"Front Pharmacol"},{"key":"16_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.610492","volume":"11","author":"T-Y Lin","year":"2021","unstructured":"Lin T-Y, Tsai M-C, Tu W, Yeh H-C, Wang S-C, Huang S-P, Li C-Y (2021) Role of the NLRP3 inflammasome: insights into cancer hallmarks. Front Immunol 11:610492","journal-title":"Front Immunol"},{"key":"16_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.649406","volume":"2","author":"J Lopez-Labady","year":"2021","unstructured":"Lopez-Labady J, Bologna-Molina R, Villarroel-Dorrego M (2021) Expression of interleukin-1\u00df and Interleukin-8 in Oral potentially malignant disorders and carcinomas. Front Oral Health 2:649406. https:\/\/doi.org\/10.3389\/froh.2021.649406","journal-title":"Front Oral Health"},{"issue":"3","key":"16_CR40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.18388\/abp.2009_2473","volume":"56","author":"M Mancuso","year":"2009","unstructured":"Mancuso M, Matassa DS, Conte M, Colella G, Rana G, Fucci L, Piscopo M (2009) H3K4 histone methylation in oral squamous cell carcinoma. Acta Biochim Pol 56(3):405\u2013410","journal-title":"Acta Biochim Pol"},{"issue":"4","key":"16_CR41","first-page":"483","volume":"24","author":"Y Marandi","year":"2021","unstructured":"Marandi Y, Hashemzade S, Tayebinia H, Karimi J, Zamani A, Khodadadi I (2021) NLRP3-inflammasome activation is associated with epithelial-mesenchymal transition and progression of colorectal cancer. Iran J Basic Med Sci 24(4):483","journal-title":"Iran J Basic Med Sci"},{"issue":"1","key":"16_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/prd.12269","volume":"82","author":"JT Marchesan","year":"2020","unstructured":"Marchesan JT, Girnary MS, Moss K, Monaghan ET, Egnatz GJ, Jiao Y, Zhang S, Beck J, Swanson KV (2020) Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics. Periodontol 82(1):93\u2013114","journal-title":"Periodontol"},{"key":"16_CR43","doi-asserted-by":"publisher","first-page":"205031212110690","DOI":"10.1177\/20503121211069012","volume":"10","author":"B Mirlekar","year":"2022","unstructured":"Mirlekar B (2022) Tumor promoting roles of IL-10, TGF-\u03b2, IL-4, and IL-35: its implications in cancer immunotherapy. SAGE Open Med 10:20503121211069012","journal-title":"SAGE Open Med"},{"key":"16_CR44","doi-asserted-by":"publisher","unstructured":"Missiroli S, Perrone M, Boncompagni C, Borghi C, Campagnaro A, Marchetti F, Anania G, Greco P, Fiorica F, Pinton P, Giorgi C (2021) Targeting the NLRP3 Inflammasome as a new therapeutic option for overcoming cancer. Cancers (Basel) 13(10). https:\/\/doi.org\/10.3390\/cancers13102297","DOI":"10.3390\/cancers13102297"},{"issue":"11","key":"16_CR45","doi-asserted-by":"publisher","first-page":"1801171","DOI":"10.1002\/mnfr.201801171","volume":"63","author":"H Neudorf","year":"2019","unstructured":"Neudorf H, Durrer C, Myette-Cote E, Makins C, O\u2019Malley T, Little JP (2019) Oral ketone supplementation acutely increases markers of NLRP3 inflammasome activation in human monocytes. Mol Nutr Food Res 63(11):1801171","journal-title":"Mol Nutr Food Res"},{"issue":"12","key":"16_CR46","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1002\/eji.201847658","volume":"48","author":"T Okano","year":"2018","unstructured":"Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T (2018) Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. Eur J Immunol 48(12):1965\u20131974","journal-title":"Eur J Immunol"},{"issue":"4","key":"16_CR47","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1399-302X.2006.00292.x","volume":"21","author":"A Orozco","year":"2006","unstructured":"Orozco A, Gemmell E, Bickel M, Seymour GJ (2006) Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microbiol Immunol 21(4):256\u2013260. https:\/\/doi.org\/10.1111\/j.1399-302X.2006.00292.x","journal-title":"Oral Microbiol Immunol"},{"issue":"Suppl 1","key":"16_CR48","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/jper.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar P, S.,\u2026Tonetti, M. S. (2018) Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions. J Periodontol 89(Suppl 1):S173\u2013s182. https:\/\/doi.org\/10.1002\/jper.17-0721","journal-title":"J Periodontol"},{"issue":"13","key":"16_CR49","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1177\/0022034520945209","volume":"99","author":"E Papathanasiou","year":"2020","unstructured":"Papathanasiou E, Conti P, Carinci F, Lauritano D, Theoharides TC (2020) IL-1 superfamily members and periodontal diseases. J Dent Res 99(13):1425\u20131434. https:\/\/doi.org\/10.1177\/0022034520945209","journal-title":"J Dent Res"},{"issue":"2","key":"16_CR50","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.molmed.2016.12.007","volume":"23","author":"MN Patel","year":"2017","unstructured":"Patel MN, Carroll RG, Galv\u00e1n-Pe\u00f1a S, Mills EL, Olden R, Triantafilou M, Wolf AI, Bryant CE, Triantafilou K, Masters SL (2017) Inflammasome priming in sterile inflammatory disease. Trends Mol Med 23(2):165\u2013180","journal-title":"Trends Mol Med"},{"issue":"1","key":"16_CR51","volume":"2015","author":"PM Peeters","year":"2015","unstructured":"Peeters PM, Wouters EF, Reynaert NL (2015) Immune homeostasis in epithelial cells: evidence and role of inflammasome signaling reviewed. J Immunol Res 2015(1):828264","journal-title":"J Immunol Res"},{"key":"16_CR52","doi-asserted-by":"publisher","unstructured":"Poli G, Fabi C, Bellet MM, Costantini C, Nunziangeli L, Romani L, Brancorsini S (2020) Epigenetic mechanisms of Inflammasome regulation. Int J Mol Sci 21(16). https:\/\/doi.org\/10.3390\/ijms21165758","DOI":"10.3390\/ijms21165758"},{"issue":"2","key":"16_CR53","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/odi.13960","volume":"29","author":"A Polizzi","year":"2023","unstructured":"Polizzi A, Santonocito S, Lo Giudice A, Alibrandi A, De Pasquale R, Isola G (2023) Analysis of the response to two pharmacological protocols in patients with oral lichen planus: A randomized clinical trial. Oral Dis 29(2):755\u2013763. https:\/\/doi.org\/10.1111\/odi.13960","journal-title":"Oral Dis"},{"issue":"5","key":"16_CR54","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1111\/odi.14758","volume":"30","author":"A Polizzi","year":"2024","unstructured":"Polizzi A, Santonocito S, Distefano A, De Pasquale R, Alibrandi A, Alanazi AM, Li Volti G, Isola G (2024) Analysis of oral lichen planus severity on micro-RNA linked with malignant transformation risks. Oral Dis 30(5):2918\u20132928. https:\/\/doi.org\/10.1111\/odi.14758","journal-title":"Oral Dis"},{"issue":"9","key":"16_CR55","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1161\/CIRCRESAHA.121.319153","volume":"129","author":"RA Porritt","year":"2021","unstructured":"Porritt RA, Zemmour D, Abe M, Lee Y, Narayanan M, Carvalho TT, Gomez AC, Martinon D, Santiskulvong C, Fishbein MC (2021) NLRP3 inflammasome mediates immune-stromal interactions in vasculitis. Circ Res 129(9):e183\u2013e200","journal-title":"Circ Res"},{"issue":"2","key":"16_CR56","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3390\/ijms23020882","volume":"23","author":"M Ptasiewicz","year":"2022","unstructured":"Ptasiewicz M, Grywalska E, Mertowska P, Korona-G\u0142owniak I, Poniewierska-Baran A, Nied\u017awiedzka-Rystwej P, Cha\u0142as R (2022) Armed to the teeth\u2014the oral mucosa immunity system and microbiota. Int J Mol Sci 23(2):882","journal-title":"Int J Mol Sci"},{"issue":"3","key":"16_CR57","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.molmed.2018.01.004","volume":"24","author":"VA Rathinam","year":"2018","unstructured":"Rathinam VA, Chan FK-M (2018) Inflammasome, inflammation, and tissue homeostasis. Trends Mol Med 24(3):304\u2013318","journal-title":"Trends Mol Med"},{"issue":"1","key":"16_CR58","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2220\/biomedres.34.31","volume":"34","author":"S Sawada","year":"2013","unstructured":"Sawada S, Chosa N, Ishisaki A, Naruishi K (2013) Enhancement of gingival inflammation induced by synergism of IL-1\u03b2 and IL-6. Biomed Res 34(1):31\u201340","journal-title":"Biomed Res"},{"issue":"1","key":"16_CR59","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/antiox11010149","volume":"11","author":"L Schieffer","year":"2022","unstructured":"Schieffer L, Manzl C, Schatz C, Haybaeck J, Crismani A (2022) Nrf2 in the field of dentistry with special attention to NLRP3. Antioxidants 11(1):149","journal-title":"Antioxidants"},{"key":"16_CR60","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/978-94-007-4525-4_27","volume":"61","author":"MK Shanmugam","year":"2013","unstructured":"Shanmugam MK, Sethi G (2013) Role of epigenetics in inflammation-associated diseases. Subcell Biochem 61:627\u2013657. https:\/\/doi.org\/10.1007\/978-94-007-4525-4_27","journal-title":"Subcell Biochem"},{"key":"16_CR61","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-981-15-3449-2_8","volume":"1253","author":"S Shao","year":"2020","unstructured":"Shao S, Gudjonsson JE (2020) Epigenetics of psoriasis. Adv Exp Med Biol 1253:209\u2013221. https:\/\/doi.org\/10.1007\/978-981-15-3449-2_8","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"16_CR62","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41368-020-00090-5","volume":"12","author":"M Sharma","year":"2020","unstructured":"Sharma M, Fonseca FP, Hunter KD, Radhakrishnan R (2020) Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation. Int J Oral Sci 12(1):23. https:\/\/doi.org\/10.1038\/s41368-020-00090-5","journal-title":"Int J Oral Sci"},{"issue":"3","key":"16_CR63","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/omi.12217","volume":"33","author":"K-i Shibata","year":"2018","unstructured":"Shibata K-i (2018) Historical aspects of studies on roles of the inflammasome in the pathogenesis of periodontal diseases. Mol Oral Microbiol 33(3):203\u2013211","journal-title":"Mol Oral Microbiol"},{"key":"16_CR64","doi-asserted-by":"publisher","unstructured":"Shih YH, Wang TH, Shieh TM, Tseng YH (2019) Oral submucous fibrosis: A review on Etiopathogenesis, diagnosis, and therapy. Int J Mol Sci 20(12). https:\/\/doi.org\/10.3390\/ijms20122940","DOI":"10.3390\/ijms20122940"},{"key":"16_CR65","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.semcancer.2021.11.002","volume":"86","author":"M Stasiewicz","year":"2022","unstructured":"Stasiewicz M, Karpi\u0144ski TM (2022) The oral microbiota and its role in carcinogenesis. Semin Cancer Biol 86:633","journal-title":"Semin Cancer Biol"},{"issue":"7381","key":"16_CR66","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nature10759","volume":"481","author":"T Strowig","year":"2012","unstructured":"Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481(7381):278\u2013286. https:\/\/doi.org\/10.1038\/nature10759","journal-title":"Nature"},{"key":"16_CR67","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ics.2005.06.071","volume":"1284","author":"N Takahashi","year":"2005","unstructured":"Takahashi N (2005) Microbial ecosystem in the oral cavity: metabolic diversity in an ecological niche and its relationship with oral diseases. Int Congr Ser 1284:103","journal-title":"Int Congr Ser"},{"issue":"9","key":"16_CR68","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41419-023-06138-8","volume":"14","author":"S Talley","year":"2023","unstructured":"Talley S, Rademacher DJ, Campbell EM (2023) Inflammasome activation occurs in CD4(+) and CD8(+) T cells during graft-versus-host disease. Cell Death Dis 14(9):632. https:\/\/doi.org\/10.1038\/s41419-023-06138-8","journal-title":"Cell Death Dis"},{"issue":"1","key":"16_CR69","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/cei.13091","volume":"192","author":"T Thi Do","year":"2018","unstructured":"Thi Do T, Phoomak C, Champattanachai V, Silsirivanit A, Chaiyarit P (2018) New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus. Clin Exp Immunol 192(1):129\u2013137","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"16_CR70","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","volume":"21","author":"S Toldo","year":"2024","unstructured":"Toldo S, Abbate A (2024) The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. Nat Rev Cardiol 21(4):219\u2013237","journal-title":"Nat Rev Cardiol"},{"key":"16_CR71","doi-asserted-by":"publisher","unstructured":"Ushio R, Hiroi M, Matsumoto A, Mori K, Yamamoto N, Ohmori Y (2022) Enhanced cytotoxic effects in human Oral squamous cell carcinoma cells treated with combined methyltransferase inhibitors and histone deacetylase inhibitors. Biomedicine 10(4). https:\/\/doi.org\/10.3390\/biomedicines10040763","DOI":"10.3390\/biomedicines10040763"},{"key":"16_CR72","first-page":"1","volume":"18","author":"H Wang","year":"2018","unstructured":"Wang H, Luo Q, Feng X, Zhang R, Li J, Chen F (2018) NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma. BMC Cancer 18:1\u201310","journal-title":"BMC Cancer"},{"issue":"8","key":"16_CR73","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1111\/odi.13704","volume":"27","author":"S Warnakulasuriya","year":"2021","unstructured":"Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, Gonz\u00e1lez-Moles M\u00c1, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR (2021) Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO collaborating Centre for Oral Cancer. Oral Dis 27(8):1862\u20131880","journal-title":"Oral Dis"},{"issue":"6","key":"16_CR74","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1007\/s10753-021-01522-y","volume":"44","author":"Y Xia","year":"2021","unstructured":"Xia Y, Zhou K, Sun M, Shu R, Qian J, Xie Y (2021) The miR-223-3p regulates Pyroptosis through NLRP3-caspase 1-GSDMD signal Axis in periodontitis. Inflammation 44(6):2531\u20132542. https:\/\/doi.org\/10.1007\/s10753-021-01522-y","journal-title":"Inflammation"},{"issue":"3","key":"16_CR75","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3892\/ijmm.2019.4075","volume":"43","author":"Y Yan","year":"2019","unstructured":"Yan Y, Lu K, Ye T, Zhang Z (2019) MicroRNA-223 attenuates LPS-induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4\/NF-\u03baB signaling pathway via RHOB. Int J Mol Med 43(3):1467\u20131477. https:\/\/doi.org\/10.3892\/ijmm.2019.4075","journal-title":"Int J Mol Med"},{"issue":"1","key":"16_CR76","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12084","volume":"69","author":"\u00d6 Yilmaz","year":"2015","unstructured":"Yilmaz \u00d6, Lee KL (2015) The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontol 69(1):83\u201395","journal-title":"Periodontol"},{"issue":"4","key":"16_CR77","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1002\/jcp.27267","volume":"234","author":"Y You","year":"2019","unstructured":"You Y, Huang Y, Wang D, Li Y, Wang G, Jin S, Zhu X, Wu B, Du X, Li X (2019) Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation. J Cell Physiol 234(4):4668\u20134680. https:\/\/doi.org\/10.1002\/jcp.27267","journal-title":"J Cell Physiol"},{"issue":"9340","key":"16_CR78","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/S0140-6736(02)11239-6","volume":"360","author":"M Zasloff","year":"2002","unstructured":"Zasloff M (2002) Innate immunity, antimicrobial peptides, and protection of the oral cavity. Lancet 360(9340):1116\u20131117","journal-title":"Lancet"},{"issue":"3","key":"16_CR79","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s10266-023-00891-0","volume":"112","author":"Y Zeng","year":"2024","unstructured":"Zeng Y, Luo M, Yao Z, Xiao X (2024) Adiponectin inhibits ROS\/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis. Odontology 112(3):811\u2013825. https:\/\/doi.org\/10.1007\/s10266-023-00891-0","journal-title":"Odontology"},{"key":"16_CR80","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.856118","volume":"10","author":"X Zhu","year":"2022","unstructured":"Zhu X, Huang H, Zhao L (2022) PAMPs and DAMPs as the bridge between periodontitis and atherosclerosis: the potential therapeutic targets. Front Cell Develop Biol 10:856118","journal-title":"Front Cell Develop Biol"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03176-1_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:32:24Z","timestamp":1784295144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03176-1_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"ISBN":["9783032031754","9783032031761"],"references-count":80,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03176-1_16","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"13 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}