{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:38:26Z","timestamp":1789094306408,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":100,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032031754","type":"print"},{"value":"9783032031761","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03176-1_28","type":"book-chapter","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:47:57Z","timestamp":1762984077000},"page":"583-603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune Responses in Orthodontic Treatment"],"prefix":"10.1007","author":[{"given":"Chen","family":"Zong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"S1","key":"28_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/ocr.12090","volume":"18","author":"M Alikhani","year":"2015","unstructured":"Alikhani M, Alyami B, Lee IS, Almoammar S, Vongthongleur T, Alikhani M, Alansari S, Sangsuwon C, Chou MY, Khoo E, Boskey A, Teixeira CC (2015) Saturation of the biological response to orthodontic forces and its effect on the rate of tooth movement. Orthod Craniofacial Res 18(S1):8\u201317. https:\/\/doi.org\/10.1111\/ocr.12090. https:\/\/pubmed.ncbi.nlm.nih.gov\/25865529\/","journal-title":"Orthod Craniofacial Res"},{"issue":"1","key":"28_CR2","doi-asserted-by":"publisher","first-page":"19018","DOI":"10.1038\/s41598-020-76038-w","volume":"10","author":"C Alvarez","year":"2020","unstructured":"Alvarez C, Suliman S, Almarhoumi R, Vega ME, Rojas C, Monasterio G, Galindo M, Vernal R, Kantarci A (2020) Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis. Sci Rep 10(1):19018. https:\/\/doi.org\/10.1038\/s41598-020-76038-w","journal-title":"Sci Rep"},{"key":"28_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107823","volume":"97","author":"M Arabpour","year":"2021","unstructured":"Arabpour M, Saghazadeh A, Rezaei N (2021) Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. Int Immunopharmacol 97:107823. https:\/\/doi.org\/10.1016\/j.intimp.2021.107823","journal-title":"Int Immunopharmacol"},{"key":"28_CR4","doi-asserted-by":"crossref","unstructured":"Babenko A, Kostiuk I, Oktysyuk Y, Avakov V, Shovkova N (2021) Cellular immunity indexes after therapeutic use of immunoactive and anti-inflammatory agents in patients with orthodontically induced gingival hyperplasia. Pharmacia 375. https:\/\/link.gale.com\/apps\/doc\/A659180297\/AONE?u=anon~fbed5e36&sid=googleScholar&xid=35dd6742","DOI":"10.3897\/pharmacia.68.e64701"},{"issue":"3","key":"28_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1684\/ecn.2019.0434","volume":"30","author":"Y Bagheri","year":"2019","unstructured":"Bagheri Y, Babaha F, Falak R, Yazdani R, Azizi G, Sadri M, Abolhassani H, Shekarabi M, Aghamohammadi A (2019) IL-10 induces TGF-\u03b2 secretion, TGF-\u03b2 receptor II upregulation, and IgA secretion in B cells. Eur Cytokine Netw 30(3):107\u2013113. https:\/\/doi.org\/10.1684\/ecn.2019.0434","journal-title":"Eur Cytokine Netw"},{"issue":"1","key":"28_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40510-020-00343-3","volume":"21","author":"H Baser Keklikci","year":"2020","unstructured":"Baser Keklikci H, Yagci A, Yay AH, Goktepe O (2020) Effects of 405-, 532-, 650-, and 940-nm wavelengths of low-level laser therapies on orthodontic tooth movement in rats. Prog Orthod 21(1):43. https:\/\/doi.org\/10.1186\/s40510-020-00343-3","journal-title":"Prog Orthod"},{"issue":"1","key":"28_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.18203\/2394-6040.ijcmph20214799","volume":"9","author":"RF Bawyan","year":"2021","unstructured":"Bawyan RF, Baajajah AJ, Alzahrani HA, Murad MA, Jamalellail HMH, Muthaffar SY, Alandijani AA, Khayat MA, Bahurmoz AA, Azab AT, Almalki MA (2021) Immunological and physiological responses related to orthodontic treatment. Int J Commun Med Public Health 9(1):394\u2013398. https:\/\/doi.org\/10.18203\/2394-6040.ijcmph20214799","journal-title":"Int J Commun Med Public Health"},{"key":"28_CR8","doi-asserted-by":"publisher","unstructured":"Behm C, Nemec M, Weissinger F, Rausch MA, Andrukhov O, Jonke E (2021) MMPs and TIMPs expression levels in the periodontal ligament during orthodontic tooth movement: a systematic review of in vitro and in vivo studies. Int J Mol Sci 22(13). https:\/\/doi.org\/10.3390\/ijms22136967","DOI":"10.3390\/ijms22136967"},{"issue":"2","key":"28_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1600-0765.2008.01127.x","volume":"44","author":"MM Bildt","year":"2009","unstructured":"Bildt MM, Bloemen M, Kuijpers-Jagtman AM, Von den Hoff JW (2009) Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells. J Periodontal Res 44(2):266\u2013274. https:\/\/doi.org\/10.1111\/j.1600-0765.2008.01127.x","journal-title":"J Periodontal Res"},{"key":"28_CR10","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.archoralbio.2016.07.004","volume":"71","author":"F Bilgic","year":"2016","unstructured":"Bilgic F, Akinci Sozer O, Ozcan O, Gurpinar AB, Yilmaz H, Ay Y (2016) Evaluation of inflammation during fixed orthodontic treatment. Arch Oral Biol 71:54\u201358. https:\/\/doi.org\/10.1016\/j.archoralbio.2016.07.004","journal-title":"Arch Oral Biol"},{"key":"28_CR11","doi-asserted-by":"publisher","first-page":"3934900","DOI":"10.1155\/2022\/3934900","volume":"2022","author":"MH Brito","year":"2022","unstructured":"Brito MH, Nogueira CQ, Cotrin P, Fialho T, Oliveira RC, Oliveira RG, Salmeron S, Valarelli FP, Freitas KMS, Can\u00e7ado RH (2022) Efficacy of low-level laser therapy in reducing pain in the initial stages of orthodontic treatment. Int J Dent 2022:3934900. https:\/\/doi.org\/10.1155\/2022\/3934900","journal-title":"Int J Dent"},{"key":"28_CR103","doi-asserted-by":"publisher","unstructured":"Butaye C, Miclotte A, Begnoni G, Zhao Z, Zong C, Willems G, Verdonck A, Jacobs R, Cadenas M (2023) Third Molar Position After Completion of Orthodontic Treatment: A Prospective Follow-Up. Dentomaxillofacial radiology, 20220432.https:\/\/doi.org\/10.1259\/dmfr.20220432","DOI":"10.1259\/dmfr.20220432"},{"key":"28_CR104","doi-asserted-by":"publisher","unstructured":"Cadenas de Llano-P\u00e9rula M, Zong C, Van Dessel J, et al (2022) 3D quantification of in vivo orthodontic tooth movement in rats by means of micro-computed tomography. Clinical Oral Investigations. https:\/\/doi.org\/10.1007\/s00784-021-04358-w","DOI":"10.1007\/s00784-021-04358-w"},{"issue":"1","key":"28_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12903-021-01519-x","volume":"21","author":"J Caviedes-Bucheli","year":"2021","unstructured":"Caviedes-Bucheli J, Lopez-Moncayo LF, Mu\u00f1oz-Alvear HD, Gomez-Sosa JF, Diaz-Barrera LE, Curtidor H, Munoz HR (2021) Expression of substance P, calcitonin gene-related peptide and vascular endothelial growth factor in human dental pulp under different clinical stimuli. BMC Oral Health 21(1):152. https:\/\/doi.org\/10.1186\/s12903-021-01519-x","journal-title":"BMC Oral Health"},{"issue":"1","key":"28_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ajodo.2020.03.035","volume":"160","author":"PO Chantarawaratit","year":"2021","unstructured":"Chantarawaratit PO, Yanisarapan T (2021) Exposure to the oral environment enhances the corrosion of metal orthodontic appliances caused by fluoride-containing products: cytotoxicity, metal ion release, and surface roughness. Am J Orthod Dentofacial Orthop 160(1):101\u2013112. https:\/\/doi.org\/10.1016\/j.ajodo.2020.03.035","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"28_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/00220345211016285","volume":"101","author":"S Chaushu","year":"2022","unstructured":"Chaushu S, Klein Y, Mandelboim O, Barenholz Y, Fleissig O (2022) Immune changes induced by orthodontic forces: a critical review. J Dent Res 101(1):11\u201320. https:\/\/doi.org\/10.1177\/00220345211016285","journal-title":"J Dent Res"},{"key":"28_CR15","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0010","volume":"33","author":"FW Degrazia","year":"2019","unstructured":"Degrazia FW, Altmann ASP, Ferreira CJ, Arthur RA, Leitune VCB, Samuel SMW, Collares FM (2019) Evaluation of an antibacterial orthodontic adhesive incorporated with niobium-based bioglass: an in situ study. Braz Oral Res 33:e010. https:\/\/doi.org\/10.1590\/1807-3107bor-2019.vol33.0010","journal-title":"Braz Oral Res"},{"issue":"5","key":"28_CR16","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jper.18-0748","volume":"91","author":"S Deng","year":"2020","unstructured":"Deng S, Hu Y, Zhou J, Wang Y, Wang Y, Li S, Huang G, Peng C, Hu A, Yu Q, Han X (2020) TLR4 mediates alveolar bone resorption in experimental peri-implantitis through regulation of CD45(+) cell infiltration, RANKL\/OPG ratio, and inflammatory cytokine production. J Periodontol 91(5):671\u2013682. https:\/\/doi.org\/10.1002\/jper.18-0748","journal-title":"J Periodontol"},{"issue":"3","key":"28_CR17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ajodo.2011.09.009","volume":"141","author":"G Doshi-Mehta","year":"2012","unstructured":"Doshi-Mehta G, Bhad-Patil WA (2012) Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop 141(3):289\u2013297. https:\/\/doi.org\/10.1016\/j.ajodo.2011.09.009","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"28_CR18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.21608\/adjg.2022.76228.1386","volume":"9","author":"OH El-sayed","year":"2022","unstructured":"El-sayed OH, Ibrahim SA, Attia MS, El Kabbany SM (2022) Assessment of pain sensation and release of RANKL in gingival crevicular fluid accompanying laser application in orthodontic treatment: a randomized controlled clinical trial. Al-Azhar Dent J Girls 9(2):355\u2013364","journal-title":"Al-Azhar Dent J Girls"},{"issue":"6","key":"28_CR19","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.ajodo.2003.09.010","volume":"124","author":"F Faccioni","year":"2003","unstructured":"Faccioni F, Franceschetti P, Cerpelloni M, Fracasso ME (2003) In vivo study on metal release from fixed orthodontic appliances and DNA damage in oral mucosa cells. Am J Orthod Dentofacial Orthop 124(6):687\u2013693.; discussion 693-684. https:\/\/doi.org\/10.1016\/j.ajodo.2003.09.010","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"10","key":"28_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800311","volume":"12","author":"MRU Fernandes","year":"2019","unstructured":"Fernandes MRU, Suzuki SS, Suzuki H, Martinez EF, Garcez AS (2019) Photobiomodulation increases intrusion tooth movement and modulates IL-6, IL-8 and IL-1\u03b2 expression during orthodontically bone remodeling. J Biophotonics 12(10):e201800311. https:\/\/doi.org\/10.1002\/jbio.201800311","journal-title":"J Biophotonics"},{"key":"28_CR21","doi-asserted-by":"publisher","first-page":"9668610","DOI":"10.1155\/2022\/9668610","volume":"2022","author":"Y Gao","year":"2022","unstructured":"Gao Y, Min Q, Li X, Liu L, Lv Y, Xu W, Liu X, Wang H (2022) Immune system acts on orthodontic tooth movement: cellular and molecular mechanisms. Biomed Res Int 2022:9668610. https:\/\/doi.org\/10.1155\/2022\/9668610","journal-title":"Biomed Res Int"},{"issue":"1","key":"28_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/iej.13839","volume":"56","author":"VK Gopinath","year":"2023","unstructured":"Gopinath VK, Mohammad MG, Sheela S (2023) Immunomodulatory effect of IL-1RA in LPS-activated macrophage\/dental pulp stem cells co-culture. Int Endod J 56(1):27\u201338. https:\/\/doi.org\/10.1111\/iej.13839","journal-title":"Int Endod J"},{"issue":"5","key":"28_CR23","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/ejo\/cjs057","volume":"35","author":"M Grant","year":"2013","unstructured":"Grant M, Wilson J, Rock P, Chapple I (2013) Induction of cytokines, MMP9, TIMPs, RANKL and OPG during orthodontic tooth movement. Eur J Orthod 35(5):644\u2013651. https:\/\/doi.org\/10.1093\/ejo\/cjs057","journal-title":"Eur J Orthod"},{"issue":"1","key":"28_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13287-020-01607-9","volume":"11","author":"D He","year":"2020","unstructured":"He D, Liu F, Cui S, Jiang N, Yu H, Zhou Y, Liu Y, Kou X (2020) Mechanical load-induced H(2)S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1. Stem Cell Res Ther 11(1):112. https:\/\/doi.org\/10.1186\/s13287-020-01607-9","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"28_CR25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s0889-5406(98)70226-4","volume":"113","author":"GR Janson","year":"1998","unstructured":"Janson GR, Dainesi EA, Consolaro A, Woodside DG, de Freitas MR (1998) Nickel hypersensitivity reaction before, during, and after orthodontic therapy. Am J Orthod Dentofacial Orthop 113(6):655\u2013660. https:\/\/doi.org\/10.1016\/s0889-5406(98)70226-4","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"5","key":"28_CR26","doi-asserted-by":"publisher","first-page":"664","DOI":"10.2319\/031520-182.1","volume":"91","author":"HH Jeon","year":"2021","unstructured":"Jeon HH, Yang CY, Shin MK, Wang J, Patel JH, Chung CH, Graves DT (2021) Osteoblast lineage cells and periodontal ligament fibroblasts regulate orthodontic tooth movement that is dependent on nuclear factor-kappa B (NF-kB) activation. Angle Orthod 91(5):664\u2013671. https:\/\/doi.org\/10.2319\/031520-182.1","journal-title":"Angle Orthod"},{"issue":"6","key":"28_CR27","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1177\/0022034515577814","volume":"94","author":"H Kanzaki","year":"2015","unstructured":"Kanzaki H, Shinohara F, Itohiya-Kasuya K, Ishikawa M, Nakamura Y (2015) Nrf2 activation attenuates both orthodontic tooth movement and relapse. J Dent Res 94(6):787\u2013794. https:\/\/doi.org\/10.1177\/0022034515577814","journal-title":"J Dent Res"},{"issue":"1","key":"28_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40510-014-0065-6","volume":"15","author":"P Kapoor","year":"2014","unstructured":"Kapoor P, Kharbanda OP, Monga N, Miglani R, Kapila S (2014) Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review. Prog Orthod 15(1):65. https:\/\/doi.org\/10.1186\/s40510-014-0065-6","journal-title":"Prog Orthod"},{"issue":"3","key":"28_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.5466\/ijoms.19.193","volume":"19","author":"J Kikuta","year":"2020","unstructured":"Kikuta J, Tsukada M, Takagi K, Shimizu M, Hikida T, Nakayama E, Kasai K (2020) TGF-\u03b21 stimulates bone resorption during orthodontic tooth movement. Int J Oral-Med Sci 19(3):193\u2013199. https:\/\/doi.org\/10.5466\/ijoms.19.193","journal-title":"Int J Oral-Med Sci"},{"issue":"6","key":"28_CR30","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/jre.12779","volume":"55","author":"AR Kim","year":"2020","unstructured":"Kim AR, Kim JH, Choi YH, Jeon YE, Cha JH, Bak EJ, Yoo YJ (2020) The presence of neutrophils causes RANKL expression in periodontal tissue, giving rise to osteoclast formation. J Periodontal Res 55(6):868\u2013876. https:\/\/doi.org\/10.1111\/jre.12779","journal-title":"J Periodontal Res"},{"key":"28_CR31","doi-asserted-by":"publisher","first-page":"2514956","DOI":"10.1155\/2019\/2514956","volume":"2019","author":"C Kirschneck","year":"2019","unstructured":"Kirschneck C, K\u00fcchler EC, Wolf M, Spanier G, Proff P, Schr\u00f6der A (2019) Effects of the highly COX-2-selective analgesic NSAID etoricoxib on human periodontal ligament fibroblasts during compressive orthodontic mechanical strain. Mediat Inflamm 2019:2514956. https:\/\/doi.org\/10.1155\/2019\/2514956","journal-title":"Mediat Inflamm"},{"key":"28_CR32","doi-asserted-by":"publisher","unstructured":"Kirschneck C, Thuy M, Leikam A, Memmert S, Deschner J, Damanaki A, Spanier G, Proff P, Jantsch J, Schr\u00f6der A (2020a) Role and regulation of mechanotransductive HIF-1\u03b1 stabilisation in periodontal ligament fibroblasts. Int J Mol Sci 21(24). https:\/\/doi.org\/10.3390\/ijms21249530","DOI":"10.3390\/ijms21249530"},{"key":"28_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2020.151585","volume":"232","author":"C Kirschneck","year":"2020","unstructured":"Kirschneck C, Wolf F, Cieplik F, Blanck-Lubarsch M, Proff P, Schr\u00f6der A (2020b) Impact of NSAID etoricoxib on side effects of orthodontic tooth movement. Ann Anat 232:151585. https:\/\/doi.org\/10.1016\/j.aanat.2020.151585","journal-title":"Ann Anat"},{"issue":"2","key":"28_CR34","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1902\/jop.2012.120061","volume":"84","author":"T Koutouzis","year":"2013","unstructured":"Koutouzis T, Catania D, Neiva K, Wallet SM (2013) Innate immune receptor expression in peri-implant tissues of patients with different susceptibility to periodontal diseases. J Periodontol 84(2):221\u2013229. https:\/\/doi.org\/10.1902\/jop.2012.120061","journal-title":"J Periodontol"},{"issue":"4","key":"28_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.166766","volume":"433","author":"WC Kuo","year":"2021","unstructured":"Kuo WC, Lee CC, Chang YW, Pang W, Chen HS, Hou SC, Lo SY, Yang AS, Wang AH (2021) Structure-based development of human interleukin-1\u03b2-specific antibody that simultaneously inhibits binding to both IL-1RI and IL-1RAcP. J Mol Biol 433(4):166766. https:\/\/doi.org\/10.1016\/j.jmb.2020.166766","journal-title":"J Mol Biol"},{"key":"28_CR36","doi-asserted-by":"publisher","unstructured":"Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Mart\u00ednez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA (2021) IL-1\u03b2-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. J Clin Invest 131(18). https:\/\/doi.org\/10.1172\/jci141008","DOI":"10.1172\/jci141008"},{"key":"28_CR37","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.archoralbio.2019.01.020","volume":"100","author":"Q Li","year":"2019","unstructured":"Li Q, Han G, Liu D, Zhou Y (2019) Force-induced decline of TEA domain family member 1 contributes to osteoclastogenesis via regulation of Osteoprotegerin. Arch Oral Biol 100:23\u201332. https:\/\/doi.org\/10.1016\/j.archoralbio.2019.01.020","journal-title":"Arch Oral Biol"},{"issue":"9","key":"28_CR38","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41419-020-02947-3","volume":"11","author":"S Li","year":"2020","unstructured":"Li S, Liu Q, Wu D, He T, Yuan J, Qiu H, Tickner J, Zheng SG, Li X, Xu J, Rong L (2020a) PKC-\u03b4 deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast-osteoblast uncoupling. Cell Death Dis 11(9):762. https:\/\/doi.org\/10.1038\/s41419-020-02947-3","journal-title":"Cell Death Dis"},{"issue":"11","key":"28_CR39","doi-asserted-by":"publisher","first-page":"15327","DOI":"10.1096\/fj.202001078R","volume":"34","author":"J Li","year":"2020","unstructured":"Li J, Yu TT, Yan HC, Qiao YQ, Wang LC, Zhang T, Li Q, Zhou YH, Liu DW (2020b) T cells participate in bone remodeling during the rapid palatal expansion. FASEB J 34(11):15327\u201315337. https:\/\/doi.org\/10.1096\/fj.202001078R","journal-title":"FASEB J"},{"issue":"3","key":"28_CR40","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.joms.2010.10.035","volume":"69","author":"EJ Liou","year":"2011","unstructured":"Liou EJ, Chen PH, Wang YC, Yu CC, Huang CS, Chen YR (2011) Surgery-first accelerated orthognathic surgery: postoperative rapid orthodontic tooth movement. J Oral Maxillofac Surg 69(3):781\u2013785. https:\/\/doi.org\/10.1016\/j.joms.2010.10.035","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"28_CR41","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1177\/0022034516685527","volume":"96","author":"Y Liu","year":"2017","unstructured":"Liu Y, Zhang T, Zhang C, Jin SS, Yang RL, Wang XD, Jiang N, Gan YH, Kou XX, Zhou YH (2017) Aspirin blocks orthodontic relapse via inhibition of CD4(+) T lymphocytes. J Dent Res 96(5):586\u2013594. https:\/\/doi.org\/10.1177\/0022034516685527","journal-title":"J Dent Res"},{"issue":"6","key":"28_CR42","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1002\/jlb.1ma1220-853rr","volume":"111","author":"J Liu","year":"2022","unstructured":"Liu J, Wang H, Zhang L, Li X, Ding X, Ding G, Wei F (2022) Periodontal ligament stem cells promote polarization of M2 macrophages. J Leukoc Biol 111(6):1185\u20131197. https:\/\/doi.org\/10.1002\/jlb.1ma1220-853rr","journal-title":"J Leukoc Biol"},{"issue":"2","key":"28_CR43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/ijos.2016.24","volume":"8","author":"H Long","year":"2016","unstructured":"Long H, Wang Y, Jian F, Liao LN, Yang X, Lai WL (2016) Current advances in orthodontic pain. Int J Oral Sci 8(2):67\u201375. https:\/\/doi.org\/10.1038\/ijos.2016.24","journal-title":"Int J Oral Sci"},{"key":"28_CR44","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.lfs.2018.03.038","volume":"201","author":"R Matsuike","year":"2018","unstructured":"Matsuike R, Tanaka H, Nakai K, Kanda M, Nagasaki M, Murakami F, Shibata C, Mayahara K, Nakajima A, Tanabe N, Kawato T, Maeno M, Shimizu N (2018) Continuous application of compressive force induces fusion of osteoclast-like RAW264.7 cells via upregulation of RANK and downregulation of LGR4. Life Sci 201:30\u201336. https:\/\/doi.org\/10.1016\/j.lfs.2018.03.038","journal-title":"Life Sci"},{"issue":"4","key":"28_CR45","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1600-0722.2009.00648.x","volume":"117","author":"L Mei","year":"2009","unstructured":"Mei L, Busscher HJ, van der Mei HC, Chen Y, de Vries J, Ren Y (2009) Oral bacterial adhesion forces to biomaterial surfaces constituting the bracket-adhesive-enamel junction in orthodontic treatment. Eur J Oral Sci 117(4):419\u2013426. https:\/\/doi.org\/10.1111\/j.1600-0722.2009.00648.x","journal-title":"Eur J Oral Sci"},{"issue":"5","key":"28_CR46","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/jre.12654","volume":"54","author":"G Monasterio","year":"2019","unstructured":"Monasterio G, Budini V, Fern\u00e1ndez B, Castillo F, Rojas C, Alvarez C, Cafferata EA, Vicencio E, Cort\u00e9s BI, Cortez C, Vernal R (2019) IL-22-expressing CD4(+) AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis. J Periodontal Res 54(5):513\u2013524. https:\/\/doi.org\/10.1111\/jre.12654","journal-title":"J Periodontal Res"},{"issue":"6","key":"28_CR47","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s11914-019-00545-7","volume":"17","author":"BS Mulholland","year":"2019","unstructured":"Mulholland BS, Forwood MR, Morrison NA (2019) Monocyte chemoattractant protein-1 (MCP-1\/CCL2) drives activation of bone remodelling and skeletal metastasis. Curr Osteoporos Rep 17(6):538\u2013547. https:\/\/doi.org\/10.1007\/s11914-019-00545-7","journal-title":"Curr Osteoporos Rep"},{"key":"28_CR48","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bbi.2019.11.023","volume":"84","author":"S Munshi","year":"2020","unstructured":"Munshi S, Loh MK, Ferrara N, DeJoseph MR, Ritger A, Padival M, Record MJ, Urban JH, Rosenkranz JA (2020) Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats. Brain Behav Immun 84:180\u2013199. https:\/\/doi.org\/10.1016\/j.bbi.2019.11.023","journal-title":"Brain Behav Immun"},{"issue":"1","key":"28_CR49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/ocr.12687","volume":"27","author":"J Naoumova","year":"2024","unstructured":"Naoumova J, Olofsson R, Almst\u00e5hl A, Cevik-Aras H (2024) Salivary levels of Osteoprotegerin and receptor activator of nuclear factor-kappa ligand during orthodontic tooth movement-a prospective pilot study. Orthod Craniofac Res 27(1):78\u201383. https:\/\/doi.org\/10.1111\/ocr.12687","journal-title":"Orthod Craniofac Res"},{"key":"28_CR50","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.archoralbio.2017.01.016","volume":"76","author":"L Nunes","year":"2017","unstructured":"Nunes L, Quintanilha L, Perinetti G, Capelli JJ (2017) Effect of orthodontic force on expression levels of ten cytokines in gingival crevicular fluid. Arch Oral Biol 76:70\u201375. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.01.016","journal-title":"Arch Oral Biol"},{"issue":"10","key":"28_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223989","volume":"14","author":"S Ogawa","year":"2019","unstructured":"Ogawa S, Kitaura H, Kishikawa A, Qi J, Shen WR, Ohori F, Noguchi T, Marahleh A, Nara Y, Ochi Y, Mizoguchi I (2019) TNF-\u03b1 is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement. PLoS One 14(10):e0223989. https:\/\/doi.org\/10.1371\/journal.pone.0223989","journal-title":"PLoS One"},{"key":"28_CR52","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3290\/j.ohpd.b2403661","volume":"19","author":"E Oikonomou","year":"2021","unstructured":"Oikonomou E, Foros P, Tagkli A, Rahiotis C, Eliades T, Koletsi D (2021) Impact of aligners and fixed appliances on oral health during orthodontic treatment: a systematic review and meta-analysis. Oral Health Prev Dent 19:659\u2013672. https:\/\/doi.org\/10.3290\/j.ohpd.b2403661","journal-title":"Oral Health Prev Dent"},{"key":"28_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154944","volume":"129","author":"A Pradeep Yeola","year":"2020","unstructured":"Pradeep Yeola A, Akbar I, Baillargeon J, Mercy Ignatius Arokia Doss P, Paavilainen VO, Rangachari M (2020) Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4(+) T cell function. Cytokine 129:154944. https:\/\/doi.org\/10.1016\/j.cyto.2019.154944","journal-title":"Cytokine"},{"issue":"6","key":"28_CR54","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/jlb.Mr0718-269r","volume":"105","author":"I Prager","year":"2019","unstructured":"Prager I, Watzl C (2019) Mechanisms of natural killer cell-mediated cellular cytotoxicity. J Leukoc Biol 105(6):1319\u20131329. https:\/\/doi.org\/10.1002\/jlb.Mr0718-269r","journal-title":"J Leukoc Biol"},{"issue":"8","key":"28_CR55","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42809","volume":"15","author":"P Prathapan Santhakumari","year":"2023","unstructured":"Prathapan Santhakumari P, Varma Raja V, Joseph J, Devaraj A, John E, Oommen Thomas N (2023) Impact of low-level laser therapy on orthodontic tooth movement and various cytokines in gingival crevicular fluid: a split-mouth randomized study. Cureus 15(8):e42809. https:\/\/doi.org\/10.7759\/cureus.42809","journal-title":"Cureus"},{"issue":"6","key":"28_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214260","volume":"14","author":"J Qi","year":"2019","unstructured":"Qi J, Kitaura H, Shen WR, Kishikawa A, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Mizoguchi I (2019) Establishment of an orthodontic retention mouse model and the effect of anti-c-Fms antibody on orthodontic relapse. PLoS One 14(6):e0214260. https:\/\/doi.org\/10.1371\/journal.pone.0214260","journal-title":"PLoS One"},{"key":"28_CR57","doi-asserted-by":"publisher","first-page":"7189084","DOI":"10.1155\/2020\/7189084","volume":"2020","author":"J Qi","year":"2020","unstructured":"Qi J, Kitaura H, Shen W-R, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Adya P, Mizoguchi I (2020) Effect of a DPP-4 inhibitor on orthodontic tooth movement and associated root resorption. Biomed Res Int 2020:7189084. https:\/\/doi.org\/10.1155\/2020\/7189084","journal-title":"Biomed Res Int"},{"issue":"10","key":"28_CR58","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1007\/s00784-020-03244-1","volume":"24","author":"B Rath-Deschner","year":"2020","unstructured":"Rath-Deschner B, Memmert S, Damanaki A, Nokhbehsaim M, Eick S, Cirelli JA, G\u00f6tz W, Deschner J, J\u00e4ger A, Nogueira AVB (2020) CXCL1, CCL2, and CCL5 modulation by microbial and biomechanical signals in periodontal cells and tissues-in vitro and in vivo studies. Clin Oral Investig 24(10):3661\u20133670. https:\/\/doi.org\/10.1007\/s00784-020-03244-1","journal-title":"Clin Oral Investig"},{"key":"28_CR59","doi-asserted-by":"publisher","unstructured":"Reale M, Costantini E, D\u2019Angelo C, Coppeta L, Mangifesta R, Jagarlapoodi S, Di Nicola M, Di Giampaolo L (2020) Network between cytokines, cortisol and occupational stress in gas and oilfield workers. Int J Mol Sci 21(3). https:\/\/doi.org\/10.3390\/ijms21031118","DOI":"10.3390\/ijms21031118"},{"issue":"2","key":"28_CR60","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s10103-021-03425-8","volume":"37","author":"CLB Reis","year":"2022","unstructured":"Reis CLB, de Souza Furtado TC, Mendes WD, Matsumoto MAN, Alves SYF, Stuani MBS, Borsatto MC, Corona SAM (2022) Photobiomodulation impacts the levels of inflammatory mediators during orthodontic tooth movement? A systematic review with meta-analysis. Lasers Med Sci 37(2):771\u2013787. https:\/\/doi.org\/10.1007\/s10103-021-03425-8","journal-title":"Lasers Med Sci"},{"issue":"3","key":"28_CR61","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1902\/jop.2007.060261","volume":"78","author":"Y Ren","year":"2007","unstructured":"Ren Y, Hazemeijer H, de Haan B, Qu N, de Vos P (2007) Cytokine profiles in crevicular fluid during orthodontic tooth movement of short and long durations. J Periodontol 78(3):453\u2013458. https:\/\/doi.org\/10.1902\/jop.2007.060261","journal-title":"J Periodontol"},{"key":"28_CR62","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/jir.S287453","volume":"14","author":"A Ren","year":"2021","unstructured":"Ren A, Li Z, Zhang X, Deng R, Ma Y (2021) Inhibition of dectin-1 on dendritic cells prevents maturation and prolongs murine islet allograft survival. J Inflamm Res 14:63\u201373. https:\/\/doi.org\/10.2147\/jir.S287453","journal-title":"J Inflamm Res"},{"key":"28_CR63","doi-asserted-by":"publisher","unstructured":"Roth CE, Craveiro RB, Niederau C, Malyaran H, Neuss S, Jankowski J, Wolf M (2022) Mechanical compression by simulating orthodontic tooth movement in an in vitro model modulates phosphorylation of AKT and MAPKs via TLR4 in human periodontal ligament cells. Int J Mol Sci 23(15). https:\/\/doi.org\/10.3390\/ijms23158062","DOI":"10.3390\/ijms23158062"},{"key":"28_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.bone.2019.03.024","volume":"123","author":"M Sakamoto","year":"2019","unstructured":"Sakamoto M, Fukunaga T, Sasaki K, Seiryu M, Yoshizawa M, Takeshita N, Takano-Yamamoto T (2019) Vibration enhances osteoclastogenesis by inducing RANKL expression via NF-\u03baB signaling in osteocytes. Bone 123:56\u201366. https:\/\/doi.org\/10.1016\/j.bone.2019.03.024","journal-title":"Bone"},{"key":"28_CR65","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2023.vol37.0010","volume":"37","author":"LLD Santos","year":"2023","unstructured":"Santos LLD, Conti A, Fernandes TMF, Garlet GP, Almeida MR, Oltramari PVP (2023) Influence of anxiety and catastrophizing on pain perception in orthodontic treatment and its association with inflammatory cytokines. Braz Oral Res 37:e010. https:\/\/doi.org\/10.1590\/1807-3107bor-2023.vol37.0010","journal-title":"Braz Oral Res"},{"key":"28_CR66","doi-asserted-by":"publisher","first-page":"2814015","DOI":"10.1155\/2020\/2814015","volume":"2020","author":"A Schr\u00f6der","year":"2020","unstructured":"Schr\u00f6der A, K\u00e4ppler P, Nazet U, Jantsch J, Proff P, Cieplik F, Deschner J, Kirschneck C (2020) Effects of compressive and tensile strain on macrophages during simulated orthodontic tooth movement. Mediat Inflamm 2020:2814015. https:\/\/doi.org\/10.1155\/2020\/2814015","journal-title":"Mediat Inflamm"},{"issue":"2","key":"28_CR67","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s41547-019-00055-w","volume":"3","author":"Y Sedky","year":"2019","unstructured":"Sedky Y, Refaat W, Gutknecht N, ElKadi A (2019) Comparison between the effect of low-level laser therapy and corticotomy-facilitated orthodontics on RANKL release during orthodontic tooth movement: a randomized controlled trial. Lasers Dent Sci 3(2):99\u2013109. https:\/\/doi.org\/10.1007\/s41547-019-00055-w","journal-title":"Lasers Dent Sci"},{"issue":"3","key":"28_CR68","first-page":"1119","volume":"56","author":"A Sodor","year":"2015","unstructured":"Sodor A, Ogodescu AS, Petreu\u015f T, \u015ei\u015fu AM, Zetu IN (2015) Assessment of orthodontic biomaterials\u2019 cytotoxicity: an in vitro study on cell culture. Romanian J Morphol Embryol 56(3):1119\u20131125","journal-title":"Romanian J Morphol Embryol"},{"issue":"1","key":"28_CR69","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/omi.12195","volume":"33","author":"L Song","year":"2018","unstructured":"Song L, Dong G, Guo L, Graves DT (2018) The function of dendritic cells in modulating the host response. Mol Oral Microbiol 33(1):13\u201321. https:\/\/doi.org\/10.1111\/omi.12195","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"28_CR70","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1089\/ped.2022.0093","volume":"36","author":"CW Stewart","year":"2023","unstructured":"Stewart CW, Hammond CM, Godat MS, Lew DB (2023) Delayed severe gingivitis after placement of orthodontic braces in an atopic teenager: a case report and literature review. Pediatr Allergy Immunol Pulmonol 36(2):46\u201349. https:\/\/doi.org\/10.1089\/ped.2022.0093","journal-title":"Pediatr Allergy Immunol Pulmonol"},{"key":"28_CR71","doi-asserted-by":"publisher","unstructured":"Tsolakis IA, Christopoulou I, Sitaras S, Lyros I, Rontogianni A, Dalampira M, Tsolakis AI (2023) Molecular and biological aspects of orthodontic tooth movement: possibilities for bioengineering intervention: a narrative review. Bioengineering (Basel) 10(11). https:\/\/doi.org\/10.3390\/bioengineering10111275","DOI":"10.3390\/bioengineering10111275"},{"issue":"12","key":"28_CR72","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1007\/s00784-020-03324-2","volume":"24","author":"P Veloso","year":"2020","unstructured":"Veloso P, Fern\u00e1ndez A, Terraza-Aguirre C, \u00c1lvarez C, Vernal R, Escobar A, Hern\u00e1ndez M (2020) Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis. Clin Oral Investig 24(12):4571\u20134581. https:\/\/doi.org\/10.1007\/s00784-020-03324-2","journal-title":"Clin Oral Investig"},{"issue":"7","key":"28_CR73","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1177\/0022034520984774","volume":"100","author":"S Wald","year":"2021","unstructured":"Wald S, Leibowitz A, Aizenbud Y, Saba Y, Zubeidat K, Barel O, Koren N, Heyman O, Wilharm A, Sandrock I, Fleissig O, Tal Y, Prinz I, Aizenbud D, Chaushu S, Hovav AH (2021) \u03b3\u03b4T cells are essential for orthodontic tooth movement. J Dent Res 100(7):731\u2013738. https:\/\/doi.org\/10.1177\/0022034520984774","journal-title":"J Dent Res"},{"issue":"1","key":"28_CR74","doi-asserted-by":"publisher","first-page":"16788","DOI":"10.1038\/s41598-018-34907-5","volume":"8","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zhang H, Sun W, Wang S, Zhang S, Zhu L, Chen Y, Xie L, Sun Z, Yan B (2018) Macrophages mediate corticotomy-accelerated orthodontic tooth movement. Sci Rep 8(1):16788. https:\/\/doi.org\/10.1038\/s41598-018-34907-5","journal-title":"Sci Rep"},{"issue":"1","key":"28_CR75","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4103\/1673-5374.243719","volume":"14","author":"XL Wang","year":"2019","unstructured":"Wang XL, Cui LW, Liu Z, Gao YM, Wang S, Li H, Liu HX, Yu LJ (2019a) Effects of TRPA1 activation and inhibition on TRPA1 and CGRP expression in dorsal root ganglion neurons. Neural Regen Res 14(1):140\u2013148. https:\/\/doi.org\/10.4103\/1673-5374.243719","journal-title":"Neural Regen Res"},{"key":"28_CR76","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.imlet.2019.03.018","volume":"209","author":"J Wang","year":"2019","unstructured":"Wang J, Jiang H, Qiu Y, Wang Y, Sun G, Zhao J (2019b) Effector memory regulatory T cells were most effective at suppressing RANKL but their frequency was downregulated in tibial fracture patients with delayed union. Immunol Lett 209:21\u201327. https:\/\/doi.org\/10.1016\/j.imlet.2019.03.018","journal-title":"Immunol Lett"},{"key":"28_CR77","doi-asserted-by":"publisher","unstructured":"Wang Y, Groeger S, Yong J, Ruf S (2023) Orthodontic compression enhances macrophage M2 polarization via histone H3 hyperacetylation. Int J Mol Sci 24(4). https:\/\/doi.org\/10.3390\/ijms24043117","DOI":"10.3390\/ijms24043117"},{"key":"28_CR78","doi-asserted-by":"publisher","unstructured":"Wei T, Shan Z, Wen X, Zhao N, Shen G (2022) Dynamic alternations of RANKL\/OPG ratio expressed by cementocytes in response to orthodontic-induced external apical root resorption in a rat model. Mol Med Rep 26(1). https:\/\/doi.org\/10.3892\/mmr.2022.12744","DOI":"10.3892\/mmr.2022.12744"},{"issue":"2","key":"28_CR79","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/odi.13239","volume":"26","author":"L Wu","year":"2020","unstructured":"Wu L, Su Y, Lin F, Zhu S, Wang J, Hou Y, Du J, Liu Y, Guo L (2020) MicroRNA-21 promotes orthodontic tooth movement by modulating the RANKL\/OPG balance in T cells. Oral Dis 26(2):370\u2013380. https:\/\/doi.org\/10.1111\/odi.13239","journal-title":"Oral Dis"},{"key":"28_CR80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835986","volume":"13","author":"H Xu","year":"2022","unstructured":"Xu H, Zhang S, Sathe AA, Jin Z, Guan J, Sun W, Xing C, Zhang H, Yan B (2022) CCR2(+) Macrophages promote orthodontic tooth movement and alveolar bone remodeling. Front Immunol 13:835986. https:\/\/doi.org\/10.3389\/fimmu.2022.835986","journal-title":"Front Immunol"},{"key":"28_CR81","doi-asserted-by":"publisher","unstructured":"Yamaguchi M, Fukasawa S (2021) Is inflammation a friend or foe for orthodontic treatment?: Inflammation in orthodontically induced inflammatory root resorption and accelerating tooth movement. Int J Mol Sci 22(5). https:\/\/doi.org\/10.3390\/ijms22052388","DOI":"10.3390\/ijms22052388"},{"issue":"10","key":"28_CR82","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1177\/0022034515595003","volume":"94","author":"Y Yan","year":"2015","unstructured":"Yan Y, Liu F, Kou X, Liu D, Yang R, Wang X, Song Y, He D, Gan Y, Zhou Y (2015) T cells are required for orthodontic tooth movement. J Dent Res 94(10):1463\u20131470. https:\/\/doi.org\/10.1177\/0022034515595003","journal-title":"J Dent Res"},{"issue":"10","key":"28_CR83","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/s1995-7645(13)60133-9","volume":"6","author":"JH Yang","year":"2013","unstructured":"Yang JH, Li ZC, Kong WD, Zhang W, Jia YP, Zhang YL, Liu LB, Han XP (2013) Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats. Asian Pac J Trop Med 6(10):757\u2013761. https:\/\/doi.org\/10.1016\/s1995-7645(13)60133-9","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"28_CR84","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40510-019-0292-y","volume":"20","author":"L Yang","year":"2019","unstructured":"Yang L, Yin G, Liao X, Yin X, Ye N (2019) A novel customized ceramic bracket for esthetic orthodontics: in vitro study. Prog Orthod 20(1):39. https:\/\/doi.org\/10.1186\/s40510-019-0292-y","journal-title":"Prog Orthod"},{"key":"28_CR85","doi-asserted-by":"publisher","unstructured":"Zeng M, Kou X, Yang R, Liu D, Wang X, Song Y, Zhang J, Yan Y, Liu F, He D, Gan Y, Zhou Y (2015) Orthodontic force induces systemic inflammatory monocyte responses. J Dent Res 94(9):1295\u20131302. https:\/\/doi.org\/10.1177\/0022034515592868","DOI":"10.1177\/0022034515592868"},{"issue":"2","key":"28_CR86","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/omi.12252","volume":"34","author":"MY Zeng","year":"2019","unstructured":"Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J (2019) The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol 34(2):27\u201338. https:\/\/doi.org\/10.1111\/omi.12252","journal-title":"Mol Oral Microbiol"},{"issue":"4","key":"28_CR87","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ajodo.2017.01.028","volume":"152","author":"J Zhang","year":"2017","unstructured":"Zhang J, Zhang AM, Zhang ZM, Jia JL, Sui XX, Yu LR, Liu HT (2017) Efficacy of combined orthodontic-periodontic treatment for patients with periodontitis and its effect on inflammatory cytokines: a comparative study. Am J Orthod Dentofacial Orthop 152(4):494\u2013500. https:\/\/doi.org\/10.1016\/j.ajodo.2017.01.028","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"4","key":"28_CR88","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3760\/cma.j.cn112144-20221031-00561","volume":"58","author":"KJ Zhang","year":"2023","unstructured":"Zhang KJ, Zhang HW, Yan B (2023) Research progress in immunomodulation in orthodontic tooth movement. Zhonghua Kou Qiang Yi Xue Za Zhi 58(4):380\u2013385. https:\/\/doi.org\/10.3760\/cma.j.cn112144-20221031-00561","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"1","key":"28_CR89","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ajodo.2011.06.035","volume":"141","author":"N Zhao","year":"2012","unstructured":"Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, Liu Y (2012) Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 141(1):30\u201340. https:\/\/doi.org\/10.1016\/j.ajodo.2011.06.035","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"28_CR100","doi-asserted-by":"publisher","unstructured":"Zhao Z, Tarce M, Georgopoulou M, Zong C, Van Holm W, Attanasio C, Pedano MS, Cadenas M (2024a) Periodontal Ligament Reactions to Orthodontic Force: A Transcriptomic Study on Maxillary and Mandibular Human Premolars. J of periodontal research. https:\/\/doi.org\/10.1111\/jre.13352","DOI":"10.1111\/jre.13352"},{"key":"28_CR101","doi-asserted-by":"publisher","unstructured":"Zhao Z, Attanasio C, Zong C, Pedano MS, Cadenas M (2024b) How Does Orthodontic Tooth Movement Influence the Dental Pulp? RNA-sequencing on Human Premolars. Int End J. https:\/\/doi.org\/10.1111\/iej.14131","DOI":"10.1111\/iej.14131"},{"issue":"1","key":"28_CR90","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s12903-021-01684-z","volume":"21","author":"J Zheng","year":"2021","unstructured":"Zheng J, Yang K (2021) Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health 21(1):324. https:\/\/doi.org\/10.1186\/s12903-021-01684-z","journal-title":"BMC Oral Health"},{"issue":"3","key":"28_CR91","doi-asserted-by":"publisher","first-page":"173","DOI":"10.21101\/cejph.a7122","volume":"30","author":"M Zigante","year":"2022","unstructured":"Zigante M, \u0160palj S (2022) Clinical predictors of metal allergic sensitization in orthodontic patients. Cent. Eur J Pub Health 30(3):173\u2013178. https:\/\/doi.org\/10.21101\/cejph.a7122","journal-title":"Eur J Pub Health"},{"issue":"1","key":"28_CR92","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40510-020-00318-4","volume":"21","author":"M Zigante","year":"2020","unstructured":"Zigante M, Rincic Mlinaric M, Kastelan M, Perkovic V, Trinajstic Zrinski M, Spalj S (2020) Symptoms of titanium and nickel allergic sensitization in orthodontic treatment. Prog Orthod 21(1):17. https:\/\/doi.org\/10.1186\/s40510-020-00318-4","journal-title":"Prog Orthod"},{"issue":"1","key":"28_CR93","doi-asserted-by":"publisher","first-page":"13672","DOI":"10.1038\/s41598-022-17412-8","volume":"12","author":"C Zong","year":"2022","unstructured":"Zong C, Van Dessel J, Vande Velde G, Willems G, Cadenas de Llano-P\u00e9rula M (2022) Dynamic changes in tooth displacement and bone morphometry induced by orthodontic force. Sci Rep 12(1):13672. https:\/\/doi.org\/10.1038\/s41598-022-17412-8","journal-title":"Sci Rep"},{"key":"28_CR94","doi-asserted-by":"publisher","unstructured":"Zong C, Bronckaers A, Willems G, He H, Cadenas de Llano-P\u00e9rula M (2023a) Nanomaterials for periodontal tissue regeneration: progress, challenges and future perspectives. J Funct Biomater 14(6). https:\/\/doi.org\/10.3390\/jfb14060290","DOI":"10.3390\/jfb14060290"},{"issue":"15","key":"28_CR95","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300328","volume":"12","author":"C Zong","year":"2023","unstructured":"Zong C, Van Holm W, Bronckaers A, Zhao Z, \u010coki\u0107 S, Aktan MK, Castro AB, Van Meerbeek B, Braem A, Willems G, Cadenas de Llano-P\u00e9rula M (2023b) Biomimetic periodontal ligament transplantation activated by gold nanoparticles protects alveolar bone. Adv Healthc Mater 12(15):e2300328. https:\/\/doi.org\/10.1002\/adhm.202300328","journal-title":"Adv Healthc Mater"},{"key":"28_CR102","doi-asserted-by":"publisher","unstructured":"Zong C, Tan X, Van Holm W, et al (2025) Biomimetic-Engineered Hydrogels Prevent Orthodontic Root Resorption. Advanced Functional Materials n\/a(n\/a):2502066. https:\/\/doi.org\/10.1002\/adfm.202502066","DOI":"10.1002\/adfm.202502066"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03176-1_28","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:33:17Z","timestamp":1784295197000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03176-1_28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"ISBN":["9783032031754","9783032031761"],"references-count":100,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03176-1_28","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"13 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}