{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:09:04Z","timestamp":1784297344266,"version":"3.55.0"},"publisher-location":"Cham","reference-count":114,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032031754","type":"print"},{"value":"9783032031761","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03176-1_37","type":"book-chapter","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:48:06Z","timestamp":1762984086000},"page":"775-794","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dental Pulp-Derived Stem Cells in Mitigating Inflammatory Arthritis and Their Mechanisms in Conjunction with Oral Diseases"],"prefix":"10.1007","author":[{"given":"Prathyusha","family":"Naidu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiranmoy","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"1","key":"37_CR1","doi-asserted-by":"publisher","first-page":"2197779","DOI":"10.1080\/20002297.2023.2197779","volume":"15","author":"AA Abdulkareem","year":"2023","unstructured":"Abdulkareem AA, Al-Taweel FB, Al-Sharqi AJ, Gul SS, Sha A, Chapple IL (2023) Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis. J Oral Microbiol 15(1):2197779","journal-title":"J Oral Microbiol"},{"issue":"5","key":"37_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","volume":"11","author":"L Abdulkhaleq","year":"2018","unstructured":"Abdulkhaleq L, Assi M, Abdullah R, Zamri-Saad M, Taufiq-Yap Y, Hezmee M (2018) The crucial roles of inflammatory mediators in inflammation: a review. Vet World 11(5):627","journal-title":"Vet World"},{"issue":"4","key":"37_CR3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s11515-011-1123-9","volume":"6","author":"AU Ahmed","year":"2011","unstructured":"Ahmed AU (2011) An overview of inflammation: mechanism and consequences. Front Biol 6(4):274\u2013281","journal-title":"Front Biol"},{"issue":"9","key":"37_CR4","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European league against rheumatism collaborative initiative. Arthritis Rheum 62(9):2569\u20132581","journal-title":"Arthritis Rheum"},{"issue":"8","key":"37_CR5","first-page":"1999","volume":"10","author":"S Anderson","year":"2022","unstructured":"Anderson S, Prateeksha P, Das H (2022) Dental pulp-derived stem cells reduce inflammation, accelerate wound healing and mediate M2 polarization of myeloid cells. Biomedicine 10(8):1999","journal-title":"Biomedicine"},{"issue":"7","key":"37_CR6","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1634\/stemcells.2007-0979","volume":"26","author":"A Arthur","year":"2008","unstructured":"Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S (2008) Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells 26(7):1787\u20131795","journal-title":"Stem Cells"},{"issue":"1","key":"37_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20140712","volume":"462","author":"JJ Babon","year":"2014","unstructured":"Babon JJ, Lucet IS, Murphy JM, Nicola NA, Varghese LN (2014) The molecular regulation of Janus kinase (JAK) activation. Biochem J 462(1):1\u201313","journal-title":"Biochem J"},{"issue":"21","key":"37_CR8","doi-asserted-by":"publisher","first-page":"12018","DOI":"10.3390\/ijms222112018","volume":"22","author":"JK Bar","year":"2021","unstructured":"Bar JK, Lis-Nawara A, Grelewski PG (2021) Dental pulp stem cell-derived secretome and its regenerative potential. Int J Mol Sci 22(21):12018","journal-title":"Int J Mol Sci"},{"issue":"15","key":"37_CR9","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","volume":"336","author":"PJ Barnes","year":"1997","unstructured":"Barnes PJ, Karin M (1997) Nuclear factor-\u03baB\u2014a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336(15):1066\u20131071","journal-title":"N Engl J Med"},{"key":"37_CR10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00251-011-0528-6","volume":"63","author":"M Bax","year":"2011","unstructured":"Bax M, van Heemst J, Huizinga TW, Toes RE (2011) Genetics of rheumatoid arthritis: what have we learned? Immunogenetics 63:459\u2013466","journal-title":"Immunogenetics"},{"issue":"11","key":"37_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113419","volume":"9","author":"M Boyle","year":"2014","unstructured":"Boyle M, Chun C, Strojny C, Narayanan R, Bartholomew A, Sundivakkam P, Alapati S (2014) Chronic inflammation and angiogenic signaling axis impairs differentiation of dental-pulp stem cells. PLoS One 9(11):e113419","journal-title":"PLoS One"},{"issue":"1","key":"37_CR12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2741\/1817","volume":"11","author":"PS Burrage","year":"2006","unstructured":"Burrage PS, Mix KS, Brinckerhoff CE (2006) Matrix metalloproteinases: role in arthritis. Front Biosci 11(1):529\u2013543","journal-title":"Front Biosci"},{"issue":"6","key":"37_CR13","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9(6):7204","journal-title":"Oncotarget"},{"key":"37_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2019.100485","volume":"18","author":"L Chen","year":"2020","unstructured":"Chen L, Liu G, Wu J, Zhou X, Zhao Y, Chen Z, Lin Z, Xiao Y (2020) Multi-faceted effects of mesenchymal stem cells (MSCs) determined by immune microenvironment and their implications on MSC\/biomaterial-based inflammatory disease therapy. Appl Mater Today 18:100485","journal-title":"Appl Mater Today"},{"issue":"4","key":"37_CR15","first-page":"499","volume":"56","author":"W Chen","year":"2024","unstructured":"Chen W, Wang Q, Tao H, Lu L, Zhou J, Wang Q, Huang W, Yang X (2024a) Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues: the role of OCs in OA. Acta Biochim Biophys Sin 56(4):499","journal-title":"Acta Biochim Biophys Sin"},{"key":"37_CR16","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17953","volume":"12","author":"Z Chen","year":"2024","unstructured":"Chen Z, Lang G, Xu X, Liang X, Han Y, Han Y (2024b) The role of NF-kappaB in the inflammatory processes related to dental caries, pulpitis, apical periodontitis, and periodontitis\u2013a narrative review. PeerJ 12:e17953","journal-title":"PeerJ"},{"issue":"2","key":"37_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102735","volume":"20","author":"A Conforti","year":"2021","unstructured":"Conforti A, Di Cola I, Pavlych V, Ruscitti P, Berardicurti O, Ursini F, Giacomelli R, Cipriani P (2021) Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. Autoimmun Rev 20(2):102735","journal-title":"Autoimmun Rev"},{"issue":"2","key":"37_CR18","first-page":"254","volume":"10","author":"SA Dabravolski","year":"2022","unstructured":"Dabravolski SA, Sukhorukov VN, Kalmykov VA, Grechko AV, Shakhpazyan NK, Orekhov AN (2022) The role of KLF2 in the regulation of atherosclerosis development and potential use of KLF2-targeted therapy. Biomedicine 10(2):254","journal-title":"Biomedicine"},{"issue":"17","key":"37_CR19","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1073\/pnas.0508235103","volume":"103","author":"H Das","year":"2006","unstructured":"Das H, Kumar A, Lin Z, Patino WD, Hwang PM, Feinberg MW, Majumder PK, Jain MK (2006) Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci USA 103(17):6653\u20136658. https:\/\/doi.org\/10.1073\/pnas.0508235103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"37_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/156652412798889090","volume":"12","author":"M Das","year":"2012","unstructured":"Das M, Lu J, Joseph M, Aggarwal R, Kanji S, McMichael BK, Lee BS, Agarwal S, Ray-Chaudhury A, Iwenofu OH, Kuppusamy P, Pompili VJ, Jain MK, Das H (2012) Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1beta-induced arthritis. Curr Mol Med 12(2):113\u2013125. https:\/\/doi.org\/10.2174\/156652412798889090","journal-title":"Curr Mol Med"},{"key":"37_CR21","doi-asserted-by":"publisher","unstructured":"Das M, Deb M, Laha D, Joseph M, Kanji S, Aggarwal R, Iwenofu OH, Pompili VJ, Jarjour W, Das H (2019) Myeloid Kruppel-like factor 2 critically regulates K\/BxN serum-induced arthritis. Cells 8(8). https:\/\/doi.org\/10.3390\/cells8080908","DOI":"10.3390\/cells8080908"},{"issue":"1","key":"37_CR22","first-page":"70","volume":"35","author":"P De Pablo","year":"2008","unstructured":"De Pablo P, Dietrich T, McAlindon TE (2008) Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J Rheumatol 35(1):70\u201376","journal-title":"J Rheumatol"},{"issue":"4","key":"37_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/CJI.0b013e3181d32e74","volume":"33","author":"S Demaria","year":"2010","unstructured":"Demaria S, Pikarsky E, Karin M, Coussens LM, Chen Y-C, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E (2010) Cancer and inflammation: promise for biologic therapy. J Immunother 33(4):335\u2013351","journal-title":"J Immunother"},{"key":"37_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00393-009-0560-1","volume":"69","author":"J Detert","year":"2010","unstructured":"Detert J, Pischon N, Burmester G, Buttgereit F (2010a) Pathogenese der Parodontitis bei rheumatischen Erkrankungen. Z Rheumatol 69:109\u2013112","journal-title":"Z Rheumatol"},{"key":"37_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar3106","volume":"12","author":"J Detert","year":"2010","unstructured":"Detert J, Pischon N, Burmester GR, Buttgereit F (2010b) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12:1\u20137","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"37_CR26","volume":"2013","author":"A Di Benedetto","year":"2013","unstructured":"Di Benedetto A, Gigante I, Colucci S, Grano M (2013) Periodontal disease: linking the primary inflammation to bone loss. J Immunol Res 2013(1):503754","journal-title":"J Immunol Res"},{"key":"37_CR27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fphys.2015.00213","volume":"6","author":"M Ducret","year":"2015","unstructured":"Ducret M, Fabre H, Degoul O, Atzeni G, McGuckin C, Forraz N, Alliot-Licht B, Mallein-Gerin F, Perrier-Groult E, Farges J-C (2015) Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations. Front Physiol 6:213","journal-title":"Front Physiol"},{"issue":"5","key":"37_CR28","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/mi.2015.136","volume":"9","author":"N Dutzan","year":"2016","unstructured":"Dutzan N, Konkel JE, Greenwell-Wild T, Moutsopoulos NM (2016) Characterization of the human immune cell network at the gingival barrier. Mucosal Immunol 9(5):1163\u20131172","journal-title":"Mucosal Immunol"},{"issue":"5","key":"37_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1089\/ten.teb.2019.0106","volume":"25","author":"KM Fawzy El-Sayed","year":"2019","unstructured":"Fawzy El-Sayed KM, Elsalawy R, Ibrahim N, Gadalla M, Albargasy H, Zahra N, Mokhtar S, El Nahhas N, El Kaliouby Y, Doerfer CE (2019) The dental pulp stem\/progenitor cells-mediated inflammatory-regenerative axis. Tissue Eng Part B Rev 25(5):445\u2013460","journal-title":"Tissue Eng Part B Rev"},{"issue":"7","key":"37_CR30","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/jcpe.12931","volume":"45","author":"F Ferrarotti","year":"2018","unstructured":"Ferrarotti F, Romano F, Gamba MN, Quirico A, Giraudi M, Audagna M, Aimetti M (2018) Human intrabony defect regeneration with micrografts containing dental pulp stem cells: a randomized controlled clinical trial. J Clin Periodontol 45(7):841\u2013850","journal-title":"J Clin Periodontol"},{"issue":"16","key":"37_CR31","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.3390\/ijms20163949","volume":"20","author":"C Figueredo","year":"2019","unstructured":"Figueredo C, Lira-Junior R, Love R (2019) T and B cells in periodontal disease: new functions in a complex scenario. Int J Mol Sci 20(16):3949","journal-title":"Int J Mol Sci"},{"issue":"6937","key":"37_CR32","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423(6937):356\u2013361","journal-title":"Nature"},{"key":"37_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4593","volume":"16","author":"GS Firestein","year":"2014","unstructured":"Firestein GS (2014) The disease formerly known as rheumatoid arthritis. Arthritis Res Ther 16:1\u20133","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"37_CR34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","volume":"46","author":"GS Firestein","year":"2017","unstructured":"Firestein GS, McInnes IB (2017) Immunopathogenesis of rheumatoid arthritis. Immunity 46(2):183\u2013196","journal-title":"Immunity"},{"key":"37_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fimmu.2016.00080","volume":"7","author":"NR Fuggle","year":"2016","unstructured":"Fuggle NR, Smith TO, Kaul A, Sofat N (2016) Hand to mouth: a systematic review and meta-analysis of the association between rheumatoid arthritis and periodontitis. Front Immunol 7:80","journal-title":"Front Immunol"},{"issue":"5","key":"37_CR36","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.4049\/jimmunol.0901467","volume":"184","author":"AM Grabiec","year":"2010","unstructured":"Grabiec AM, Krausz S, De Jager W, Burakowski T, Groot D, Sanders ME, Prakken BJ, Maslinski W, Eldering E, Tak PP (2010) Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol 184(5):2718\u20132728","journal-title":"J Immunol"},{"issue":"2","key":"37_CR37","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","volume":"98","author":"DT Graves","year":"2019","unstructured":"Graves DT, Corr\u00eaa JD, Silva TA (2019) The oral microbiota is modified by systemic diseases. J Dent Res 98(2):148\u2013156","journal-title":"J Dent Res"},{"issue":"25","key":"37_CR38","doi-asserted-by":"publisher","first-page":"13625","DOI":"10.1073\/pnas.240309797","volume":"97","author":"S Gronthos","year":"2000","unstructured":"Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci 97(25):13625\u201313630","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"37_CR39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/0022034514526240","volume":"26","author":"G Hajishengallis","year":"2014","unstructured":"Hajishengallis G, Sahingur S (2014) Novel inflammatory pathways in periodontitis. Adv Dent Res 26(1):23\u201329","journal-title":"Adv Dent Res"},{"key":"37_CR40","volume-title":"Acute inflammatory response","author":"S Hannoodee","year":"2020","unstructured":"Hannoodee S, Nasuruddin DN (2020) Acute inflammatory response"},{"issue":"1","key":"37_CR41","first-page":"8890873","volume":"2020","author":"B Hern\u00e1ndez-Monjaraz","year":"2020","unstructured":"Hern\u00e1ndez-Monjaraz B, Santiago-Osorio E, Ledesma-Mart\u00ednez E, Agui\u00f1iga-S\u00e1nchez I, Sosa-Hern\u00e1ndez NA, Mendoza-N\u00fa\u00f1ez VM (2020) Dental pulp mesenchymal stem cells as a treatment for periodontal disease in older adults. Stem Cells Int 2020(1):8890873","journal-title":"Stem Cells Int"},{"issue":"5","key":"37_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41571-020-00459-9","volume":"18","author":"J Hou","year":"2021","unstructured":"Hou J, Karin M, Sun B (2021) Targeting cancer-promoting inflammation\u2014have anti-inflammatory therapies come of age? Nat Rev Clin Oncol 18(5):261\u2013279","journal-title":"Nat Rev Clin Oncol"},{"key":"37_CR43","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1902\/jop.1993.64.8s.828","volume":"64","author":"TH Howell","year":"1993","unstructured":"Howell TH (1993) Blocking periodontal disease progression with anti-inflammatory agents. J Periodontol 64:828\u2013833","journal-title":"J Periodontol"},{"issue":"3","key":"37_CR44","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/jocd.13595","volume":"20","author":"MA Ibrahim","year":"2021","unstructured":"Ibrahim MA, Mohammed SA, Elhabak DM (2021) Role of KLF2: new insight in inflammatory acne pathogenesis. J Cosmet Dermatol 20(3):964\u2013970","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"37_CR45","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev.pathol.4.110807.092254","volume":"4","author":"JB Imboden","year":"2009","unstructured":"Imboden JB (2009) The immunopathogenesis of rheumatoid arthritis. Ann Rev Pathol Mech Dis 4(1):417\u2013434","journal-title":"Ann Rev Pathol Mech Dis"},{"issue":"1","key":"37_CR46","first-page":"8","volume":"44","author":"S Iqbal","year":"2019","unstructured":"Iqbal S, Rattu MA (2019) Review of rheumatoid arthritis. US Pharm 44(1):8\u201311","journal-title":"US Pharm"},{"issue":"11","key":"37_CR47","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.3390\/ijms18112383","volume":"18","author":"P Jha","year":"2017","unstructured":"Jha P, Das H (2017) KLF2 in regulation of NF-\u03baB-mediated immune cell function and inflammation. Int J Mol Sci 18(11):2383","journal-title":"Int J Mol Sci"},{"issue":"5","key":"37_CR48","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34(5):637\u2013650","journal-title":"Immunity"},{"issue":"2","key":"37_CR49","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.cellsig.2012.10.014","volume":"25","author":"MJ Kipanyula","year":"2013","unstructured":"Kipanyula MJ, Etet PFS, Vecchio L, Farahna M, Nukenine EN, Kamdje AHN (2013) Signaling pathways bridging microbial-triggered inflammation and cancer. Cell Signal 25(2):403\u2013416","journal-title":"Cell Signal"},{"issue":"4","key":"37_CR50","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides T (2007) Chromatin modifications and their function. Cell 128(4):693\u2013705","journal-title":"Cell"},{"key":"37_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11926-014-0408-9","volume":"16","author":"J Koziel","year":"2014","unstructured":"Koziel J, Mydel P, Potempa J (2014) The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep 16:1\u20137","journal-title":"Curr Rheumatol Rep"},{"key":"37_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar1640","volume":"7","author":"D Kyburz","year":"2005","unstructured":"Kyburz D, Brentano F, Schorr O, Michel B, Gay R, Gay S (2005) Toll-like receptor expression in synovial fibroblasts and normal skin fibroblasts and induction of matrix metallo-proteinase expression by various toll-like receptor ligands. Arthritis Res Ther 7:1\u20131","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"37_CR53","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1177\/0022034516657817","volume":"95","author":"S Lee","year":"2016","unstructured":"Lee S, Zhang Q, Karabucak B, Le A (2016) DPSCs from inflamed pulp modulate macrophage function via the TNF-\u03b1\/IDO axis. J Dent Res 95(11):1274\u20131281","journal-title":"J Dent Res"},{"issue":"2","key":"37_CR54","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2174\/1381612820666140825122036","volume":"21","author":"S Lefevre","year":"2015","unstructured":"Lefevre S, Meier F, Neumann E, Muller-Ladner U (2015) Role of synovial fibroblasts in rheumatoid arthritis. Curr Pharm Des 21(2):130\u2013141","journal-title":"Curr Pharm Des"},{"key":"37_CR55","doi-asserted-by":"publisher","first-page":"1284868","DOI":"10.3389\/fimmu.2023.1284868","volume":"14","author":"F Li","year":"2023","unstructured":"Li F, Wang X, Shi J, Wu S, Xing W, He Y (2023) Anti-inflammatory effect of dental pulp stem cells. Front Immunol 14:1284868","journal-title":"Front Immunol"},{"issue":"1","key":"37_CR56","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13287-024-03641-3","volume":"15","author":"W Li","year":"2024","unstructured":"Li W, Xiang Z, Yu W, Huang X, Jiang Q, Abumansour A, Yang Y, Chen C (2024) Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration. Stem Cell Res Ther 15(1):34","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"37_CR57","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.bioactmat.2020.02.012","volume":"5","author":"Y Liang","year":"2020","unstructured":"Liang Y, Luan X, Liu X (2020) Recent advances in periodontal regeneration: a biomaterial perspective. Bioactive Mat 5(2):297\u2013308","journal-title":"Bioactive Mat"},{"key":"37_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12015-020-10117-3","volume":"17","author":"C Liang","year":"2021","unstructured":"Liang C, Liao L, Tian W (2021) Stem cell-based dental pulp regeneration: insights from signaling pathways. Stem Cell Rev Rep 17:1\u201313","journal-title":"Stem Cell Rev Rep"},{"issue":"6","key":"37_CR59","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/biology13060431","volume":"13","author":"J Lin","year":"2024","unstructured":"Lin J, Hwang S, Luo H, Mohamud Y (2024) Double-edged sword: exploring the mitochondria\u2013complement bidirectional connection in cellular response and disease. Biology 13(6):431","journal-title":"Biology"},{"issue":"5","key":"37_CR60","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.3892\/mmr.2015.3152","volume":"11","author":"W Liu","year":"2015","unstructured":"Liu W, Zhang X (2015) Receptor activator of nuclear factor-\u03baB ligand (RANKL)\/RANK\/osteoprotegerin system in bone and other tissues. Mol Med Rep 11(5):3212\u20133218","journal-title":"Mol Med Rep"},{"issue":"12","key":"37_CR61","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1038\/nm.2542","volume":"17","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, Yang R, Chen W, Wang S, Shi S (2011) Mesenchymal stem cell\u2013based tissue regeneration is governed by recipient T lymphocytes via IFN-\u03b3 and TNF-\u03b1. Nat Med 17(12):1594\u20131601","journal-title":"Nat Med"},{"issue":"5","key":"37_CR62","doi-asserted-by":"publisher","first-page":"520","DOI":"10.7150\/ijbs.8879","volume":"10","author":"Y-C Liu","year":"2014","unstructured":"Liu Y-C, Zou X-B, Chai Y-F, Yao Y-M (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10(5):520","journal-title":"Int J Biol Sci"},{"issue":"1","key":"37_CR63","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B","volume":"43","author":"AJ MacGregor","year":"2000","unstructured":"MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthrit Rheumat Off J Am Coll Rheumatol 43(1):30\u201337","journal-title":"Arthrit Rheumat Off J Am Coll Rheumatol"},{"issue":"1","key":"37_CR64","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/prd.12269","volume":"82","author":"JT Marchesan","year":"2020","unstructured":"Marchesan JT, Girnary MS, Moss K, Monaghan ET, Egnatz GJ, Jiao Y, Zhang S, Beck J, Swanson KV (2020) Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics. Periodontol 82(1):93\u2013114","journal-title":"Periodontol"},{"issue":"5","key":"37_CR65","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2174\/138945010791011938","volume":"11","author":"KB Marcu","year":"2010","unstructured":"Marcu KB, Otero M, Olivotto E, Maria Borzi R, Goldring MB (2010) NF-\u03baB signaling: multiple angles to target OA. Curr Drug Targets 11(5):599\u2013613","journal-title":"Curr Drug Targets"},{"issue":"23","key":"37_CR66","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365(23):2205\u20132219","journal-title":"N Engl J Med"},{"issue":"10086","key":"37_CR67","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","volume":"389","author":"IB McInnes","year":"2017","unstructured":"McInnes IB, Schett G (2017) Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389(10086):2328\u20132337","journal-title":"Lancet"},{"issue":"7203","key":"37_CR68","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428\u2013435","journal-title":"Nature"},{"issue":"31","key":"37_CR69","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.3748\/wjg.v18.i31.4071","volume":"18","author":"H Nakagawa","year":"2012","unstructured":"Nakagawa H, Maeda S (2012) Inflammation-and stress-related signaling pathways in hepatocarcinogenesis. World J Gastroenterol: WJG 18(31):4071","journal-title":"World J Gastroenterol: WJG"},{"key":"37_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-017-0506-5","volume":"8","author":"M Nakashima","year":"2017","unstructured":"Nakashima M, Iohara K, Murakami M, Nakamura H, Sato Y, Ariji Y, Matsushita K (2017) Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. Stem Cell Res Ther 8:1\u201313","journal-title":"Stem Cell Res Ther"},{"key":"37_CR71","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s40496-017-0158-7","volume":"4","author":"GG Nascimento","year":"2017","unstructured":"Nascimento GG, Leite FR, Scheutz F, L\u00f3pez R (2017) Periodontitis: from infection to inflammation. Curr Oral Health Rep 4:301\u2013308","journal-title":"Curr Oral Health Rep"},{"issue":"6917","key":"37_CR72","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nature01320","volume":"420","author":"C Nathan","year":"2002","unstructured":"Nathan C (2002) Points of control in inflammation. Nature 420(6917):846\u2013852","journal-title":"Nature"},{"issue":"6","key":"37_CR73","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan C, Ding A (2010) Nonresolving inflammation. Cell 140(6):871\u2013882","journal-title":"Cell"},{"key":"37_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar1446","volume":"7","author":"PA Nigrovic","year":"2004","unstructured":"Nigrovic PA, Lee DM (2004) Mast cells in inflammatory arthritis. Arthritis Res Ther 7:1\u201311","journal-title":"Arthritis Res Ther"},{"key":"37_CR75","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.740712","volume":"9","author":"N Nowwarote","year":"2022","unstructured":"Nowwarote N, Petit S, Ferre FC, Dingli F, Laigle V, Loew D, Osathanon T, Fournier BP (2022) Extracellular matrix derived from dental pulp stem cells promotes mineralization. Front Bioeng Biotechnol 9:740712","journal-title":"Front Bioeng Biotechnol"},{"key":"37_CR76","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.reth.2021.01.006","volume":"16","author":"K Ogata","year":"2021","unstructured":"Ogata K, Matsumura-Kawashima M, Moriyama M, Kawado T, Nakamura S (2021) Dental pulp-derived stem cell-conditioned media attenuates secondary Sj\u00f6gren\u2019s syndrome via suppression of inflammatory cytokines in the submandibular glands. Regen Ther 16:73\u201380","journal-title":"Regen Ther"},{"key":"37_CR77","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40268-015-0082-z","volume":"15","author":"B Pal","year":"2015","unstructured":"Pal B, Endisha H, Zhang Y, Kapoor M (2015) mTOR: a potential therapeutic target in osteoarthritis? Drugs R&D 15:27\u201336","journal-title":"Drugs R&D"},{"issue":"1","key":"37_CR78","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvv227","volume":"109","author":"G Passacquale","year":"2016","unstructured":"Passacquale G, Di Giosia P, Ferro A (2016) The role of inflammatory biomarkers in developing targeted cardiovascular therapies: lessons from the cardiovascular inflammation reduction trials. Cardiovasc Res 109(1):9\u201323","journal-title":"Cardiovasc Res"},{"issue":"1","key":"37_CR79","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13287-025-04146-3","volume":"16","author":"B Peng","year":"2025","unstructured":"Peng B, Li Z, Cheng Y, Jiang H, Ye Q, Han G (2025) Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K\/Akt\/NF-\u03baB-mediated osteoclast activity. Stem Cell Res Ther 16(1):22","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"37_CR80","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1097\/01.tp.0000173794.72151.88","volume":"80","author":"L Pierdomenico","year":"2005","unstructured":"Pierdomenico L, Bonsi L, Calvitti M, Rondelli D, Arpinati M, Chirumbolo G, Becchetti E, Marchionni C, Alviano F, Fossati V (2005) Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation 80(6):836\u2013842","journal-title":"Transplantation"},{"issue":"6","key":"37_CR81","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1902\/jop.2008.070501","volume":"79","author":"N Pischon","year":"2008","unstructured":"Pischon N, Pischon T, Kr\u00f6ger J, G\u00fclmez E, Kleber BM, Bernimoulin JP, Landau H, Brinkmann PG, Schlattmann P, Zernicke J (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 79(6):979\u2013986","journal-title":"J Periodontol"},{"key":"37_CR82","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3389\/fphys.2018.00547","volume":"9","author":"A Pisciotta","year":"2018","unstructured":"Pisciotta A, Bertoni L, Riccio M, Mapelli J, Bigiani A, La Noce M, Orciani M, De Pol A, Carnevale G (2018) Use of a 3D floating sphere culture system to maintain the neural crest-related properties of human dental pulp stem cells. Front Physiol 9:547","journal-title":"Front Physiol"},{"issue":"10","key":"37_CR83","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"J Potempa","year":"2017","unstructured":"Potempa J, Mydel P, Koziel J (2017) The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol 13(10):606\u2013620","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"37_CR84","doi-asserted-by":"publisher","first-page":"74","DOI":"10.54457\/DR.202302006","volume":"3","author":"P Prateeksha","year":"2023","unstructured":"Prateeksha P, Howlader MSI, Hansda S, Naidu P, Das M, Abo-Aziza F, Das H (2023a) Secretome of dental pulp-derived stem cells reduces inflammation and proliferation of glioblastoma cells by deactivating Mapk-Akt pathway. Dis Res 3(2):74","journal-title":"Dis Res"},{"issue":"8","key":"37_CR85","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1007\/s12015-023-10607-0","volume":"19","author":"P Prateeksha","year":"2023","unstructured":"Prateeksha P, Naidu P, Das M, Barthels D, Das H (2023b) KLF2 regulates neural differentiation of dental pulp-derived stem cells by modulating autophagy and Mitophagy. Stem Cell Rev Rep 19(8):2886\u20132900. https:\/\/doi.org\/10.1007\/s12015-023-10607-0","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"37_CR86","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/prd.12148","volume":"76","author":"PM Preshaw","year":"2018","unstructured":"Preshaw PM (2018) Host modulation therapy with anti-inflammatory agents. Periodontol 76(1):131\u2013149","journal-title":"Periodontol"},{"key":"37_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110334","volume":"371","author":"M Purohit","year":"2023","unstructured":"Purohit M, Gupta G, Afzal O, Altamimi ASA, Alzarea SI, Kazmi I, Almalki WH, Gulati M, Kaur IP, Singh SK (2023) Janus kinase\/signal transducers and activator of transcription (JAK\/STAT) and its role in lung inflammatory disease. Chem Biol Interact 371:110334","journal-title":"Chem Biol Interact"},{"issue":"5","key":"37_CR88","doi-asserted-by":"publisher","first-page":"673","DOI":"10.26502\/acbr.50170279","volume":"6","author":"V Rai","year":"2022","unstructured":"Rai V, Mathews G, Agrawal DK (2022) Translational and clinical significance of DAMPs, PAMPs, and PRRs in trauma-induced inflammation. Arch Clin Biomed Res 6(5):673","journal-title":"Arch Clin Biomed Res"},{"issue":"9563","key":"37_CR89","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","volume":"369","author":"A Ravelli","year":"2007","unstructured":"Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369(9563):767\u2013778","journal-title":"Lancet"},{"key":"37_CR90","doi-asserted-by":"publisher","first-page":"1237729","DOI":"10.3389\/fimmu.2023.1237729","volume":"14","author":"SA Rizo-T\u00e9llez","year":"2023","unstructured":"Rizo-T\u00e9llez SA, Sekheri M, Filep JG (2023) C-reactive protein: a target for therapy to reduce inflammation. Front Immunol 14:1237729","journal-title":"Front Immunol"},{"issue":"9","key":"37_CR91","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","volume":"14","author":"J Roman-Blas","year":"2006","unstructured":"Roman-Blas J, Jimenez S (2006) NF-\u03baB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil 14(9):839\u2013848","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"37_CR92","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4103\/0974-777X.56251","volume":"1","author":"R Saini","year":"2009","unstructured":"Saini R, Marawar P, Shete S, Saini S (2009) Periodontitis, a true infection. J Global Infect Dis 1(2):149\u2013150","journal-title":"J Global Infect Dis"},{"key":"37_CR092","doi-asserted-by":"crossref","unstructured":"Scher JU, & Abramson SB (2013) Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease? Arthritis Res & Ther 15(5):122","DOI":"10.1186\/ar4360"},{"issue":"10","key":"37_CR93","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1084\/jem.20031132","volume":"199","author":"S SenBanerjee","year":"2004","unstructured":"SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW (2004) KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med 199(10):1305\u20131315","journal-title":"J Exp Med"},{"key":"37_CR94","first-page":"627","volume-title":"Role of epigenetics in inflammation-associated diseases","author":"MK Shanmugam","year":"2012","unstructured":"Shanmugam MK, Sethi G (2012) Role of epigenetics in inflammation-associated diseases. Dev Dis, Epigenetics, pp 627\u2013657"},{"issue":"1","key":"37_CR95","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bbrc.2017.10.114","volume":"495","author":"J Shi","year":"2018","unstructured":"Shi J, Zhou L-r, Wang X-s, Du J-f, Jiang M-m, Song Z, Han G-c, Mai Z-t (2018) KLF2 attenuates bleomycin-induced pulmonary fibrosis and inflammation with regulation of AP-1. Biochem Biophys Res Commun 495(1):20\u201326","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"37_CR96","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/odi.12468","volume":"23","author":"B Song","year":"2017","unstructured":"Song B, Zhang Y, Chen L, Zhou T, Huang W, Zhou X, Shao L (2017) The role of Toll-like receptors in periodontitis. Oral Dis 23(2):168\u2013180","journal-title":"Oral Dis"},{"issue":"6116","key":"37_CR97","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1126\/science.1230720","volume":"339","author":"I Tabas","year":"2013","unstructured":"Tabas I, Glass CK (2013) Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339(6116):166\u2013172","journal-title":"Science"},{"issue":"4","key":"37_CR98","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/jre.12236","volume":"50","author":"S Thorbert-Mros","year":"2015","unstructured":"Thorbert-Mros S, Larsson L, Berglundh T (2015) Cellular composition of long-standing gingivitis and periodontitis lesions. J Periodontal Res 50(4):535\u2013543","journal-title":"J Periodontal Res"},{"issue":"12","key":"37_CR99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208938","volume":"13","author":"T Tsuruta","year":"2018","unstructured":"Tsuruta T, Sakai K, Watanabe J, Katagiri W, Hibi H (2018) Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia. PLoS One 13(12):e0208938","journal-title":"PLoS One"},{"issue":"8","key":"37_CR100","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","volume":"12","author":"IA Udalova","year":"2016","unstructured":"Udalova IA, Mantovani A, Feldmann M (2016) Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol 12(8):472\u2013485","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"37_CR101","first-page":"9836518","volume":"2020","author":"M Wang","year":"2020","unstructured":"Wang M, Xie J, Wang C, Zhong D, Xie L, Fang H (2020) Immunomodulatory properties of stem cells in periodontitis: current status and future prospective. Stem Cells Int 2020(1):9836518","journal-title":"Stem Cells Int"},{"issue":"2","key":"37_CR102","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2174\/187221310791163071","volume":"4","author":"J Wei","year":"2010","unstructured":"Wei J, Feng J (2010) Signaling pathways associated with inflammatory bowel disease. Recent Patents Inflamm Allergy Drug Discov 4(2):105\u2013117","journal-title":"Recent Patents Inflamm Allergy Drug Discov"},{"issue":"9","key":"37_CR103","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","volume":"49","author":"HL Wright","year":"2010","unstructured":"Wright HL, Moots RJ, Bucknall RC, Edwards SW (2010) Neutrophil function in inflammation and inflammatory diseases. Rheumatology 49(9):1618\u20131631","journal-title":"Rheumatology"},{"issue":"8","key":"37_CR104","first-page":"9078087","volume":"10","author":"F Xiao","year":"2021","unstructured":"Xiao F, Li C, Lin Y, Peng Z, Xu X, Wen Y, Huang N, Zhang P (2021) Increased risk of periodontitis occurrence in patients with rheumatoid arthritis and its association with the levels of IL-1\u03b2 and TNF-\u03b1 in gingival crevicular fluid. Annal Palliat Med 10(8):9078087\u20139079087","journal-title":"Annal Palliat Med"},{"issue":"1","key":"37_CR105","doi-asserted-by":"publisher","first-page":"16295","DOI":"10.1038\/srep16295","volume":"5","author":"S Yamaguchi","year":"2015","unstructured":"Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A (2015) Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion. Sci Rep 5(1):16295","journal-title":"Sci Rep"},{"key":"37_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/scrt5","volume":"1","author":"T Yamaza","year":"2010","unstructured":"Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S (2010) Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 1:1\u201311","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"37_CR107","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3109\/10799893.2012.752003","volume":"33","author":"Y Yang","year":"2013","unstructured":"Yang Y, Tang L-Q, Wei W (2013) Prostanoids receptors signaling in different diseases\/cancers progression. J Recept Signal Transduct 33(1):14\u201327","journal-title":"J Recept Signal Transduct"},{"key":"37_CR108","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s00784-014-1207-4","volume":"18","author":"FB Yazid","year":"2014","unstructured":"Yazid FB, Gnanasegaran N, Kunasekaran W, Govindasamy V, Musa S (2014) Comparison of immunodulatory properties of dental pulp stem cells derived from healthy and inflamed teeth. Clin Oral Investig 18:2103\u20132112","journal-title":"Clin Oral Investig"},{"issue":"14","key":"37_CR109","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2174\/1381612824666180327165604","volume":"24","author":"YT Yeung","year":"2018","unstructured":"Yeung YT, Aziz F, Guerrero-Castilla A, Arguelles S (2018) Signaling pathways in inflammation and anti-inflammatory therapies. Curr Pharm Des 24(14):1449\u20131484","journal-title":"Curr Pharm Des"},{"issue":"4","key":"37_CR110","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.173","volume":"3","author":"S Zhang","year":"2022","unstructured":"Zhang S, Meng Y, Zhou L, Qiu L, Wang H, Su D, Zhang B, Chan KM, Han J (2022) Targeting epigenetic regulators for inflammation: mechanisms and intervention therapy. MedComm 3(4):e173","journal-title":"MedComm"},{"issue":"1","key":"37_CR111","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","volume":"6","author":"H Zhao","year":"2021","unstructured":"Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, Li Y (2021) Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther 6(1):263","journal-title":"Signal Transduct Target Ther"},{"issue":"21","key":"37_CR112","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/cells11213380","volume":"11","author":"L Zhu","year":"2022","unstructured":"Zhu L, Zhou C, Chen S, Huang D, Jiang Y, Lan Y, Zou S, Li Y (2022) Osteoporosis and alveolar bone health in periodontitis niche: a predisposing factors-centered review. Cells 11(21):3380","journal-title":"Cells"},{"key":"37_CR113","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3389\/fimmu.2018.00302","volume":"9","author":"P Zimmermann","year":"2018","unstructured":"Zimmermann P, Ziesenitz VC, Curtis N, Ritz N (2018) The immunomodulatory effects of macrolides\u2014a systematic review of the underlying mechanisms. Front Immunol 9:302","journal-title":"Front Immunol"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03176-1_37","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:02:15Z","timestamp":1784296935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03176-1_37"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"ISBN":["9783032031754","9783032031761"],"references-count":114,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03176-1_37","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"13 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}