{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:01:15Z","timestamp":1785366075429,"version":"3.55.0"},"publisher-location":"Cham","reference-count":113,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032031754","type":"print"},{"value":"9783032031761","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03176-1_9","type":"book-chapter","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:47:46Z","timestamp":1762984066000},"page":"163-178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Periodontal Disease and Osteoporosis: A Bidirectional Relationship"],"prefix":"10.1007","author":[{"given":"Maria","family":"Contaldo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"1","key":"9_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1600-051X.2007.01166.x","volume":"35","author":"A Agueda","year":"2008","unstructured":"Agueda A, Ramon JM, Manau C, Guerrero A, Echeverria JJ (2008) Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 35(1):16\u201322. https:\/\/doi.org\/10.1111\/j.1600-051X.2007.01166.x","journal-title":"J Clin Periodontol"},{"issue":"11","key":"9_CR2","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1902\/jop.2010.100190","volume":"81","author":"R Al Habashneh","year":"2010","unstructured":"Al Habashneh R, Alchalabi H, Khader YS et al (2010) Association between periodontal disease and osteoporosis in postmenopausal women in Jordan. J Periodontol 81(11):1613\u20131621. https:\/\/doi.org\/10.1902\/jop.2010.100190","journal-title":"J Periodontol"},{"key":"9_CR3","doi-asserted-by":"publisher","unstructured":"Albandar JM, Susin C, Hughes FJ (2018) Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: case definitions and diagnostic considerations. J Clin Periodontol 45(S20). https:\/\/doi.org\/10.1111\/jcpe.12947","DOI":"10.1111\/jcpe.12947"},{"issue":"37","key":"9_CR4","doi-asserted-by":"publisher","first-page":"27298","DOI":"10.1074\/jbc.M702811200","volume":"282","author":"M Almeida","year":"2007","unstructured":"Almeida M, Han L, Martin-Millan M, O\u2019Brien CA, Manolagas SC (2007) Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting \u03b2-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 282(37):27298\u201327305. https:\/\/doi.org\/10.1074\/jbc.M702811200","journal-title":"J Biol Chem"},{"issue":"2","key":"9_CR5","first-page":"273","volume":"29","author":"A Ballini","year":"2015","unstructured":"Ballini A, Cantore S, Farronato D, Cirulli N, Inchingolo F, Papa F, Malcangi G, Inchingolo AD, Dipalma G, Sardaro N, De Vito D, Scacco S (2015) Periodontal disease and bone pathogenesis: the crosstalk between cytokines and porphyromonas gingivalis. J Biol Regul Homeost Agents 29(2):273\u2013281","journal-title":"J Biol Regul Homeost Agents"},{"issue":"12","key":"9_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024263","volume":"8","author":"HR Banack","year":"2018","unstructured":"Banack HR, Genco RJ, LaMonte MJ, Millen AE, Buck MJ, Sun Y, Andrews CA, Hovey KM et al (2018) Cohort profile: the Buffalo OsteoPerio microbiome prospective cohort study. BMJ Open 8(12):e024263. https:\/\/doi.org\/10.1136\/bmjopen-2018-024263","journal-title":"BMJ Open"},{"issue":"SUPPL. 4","key":"9_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1469-0691.2012.03916.x","volume":"18","author":"F Baquero","year":"2012","unstructured":"Baquero F, Nombela C (2012) The microbiome as a human organ. Clin Microbiol Infect 18(SUPPL. 4):2\u20134. https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03916.x","journal-title":"Clin Microbiol Infect"},{"key":"9_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115317","volume":"135","author":"J Behera","year":"2020","unstructured":"Behera J, Ison J, Tyagi SC, Tyagi N (2020) The role of gut microbiota in bone homeostasis. Bone 135:115317. https:\/\/doi.org\/10.1016\/j.bone.2020.115317","journal-title":"Bone"},{"key":"9_CR9","doi-asserted-by":"publisher","unstructured":"Berg G, Rybakova D, Fischer D, Cernava T, Verg\u00e8s M-CC, Charles T, Chen X, Cocolin L, Eversole K, Corral GH, Sessitsch A, Schloter M (2020) Microbiome definition re-visited: old concepts and new challenges. Microbiome 8(1). https:\/\/doi.org\/10.1186\/s40168-020-00875-0","DOI":"10.1186\/s40168-020-00875-0"},{"key":"9_CR10","doi-asserted-by":"publisher","unstructured":"Berg Y, Gabay E, Bo\u017ei\u0107 D, Shibli JA, Ginesin O, Asbi T, Takakura L, Mayer Y (2024) The impact of nutritional components on periodontal health: a literature review. Nutrients 16(22). https:\/\/doi.org\/10.3390\/nu16223901","DOI":"10.3390\/nu16223901"},{"issue":"18","key":"9_CR11","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1056\/NEJMoa067312","volume":"356","author":"DM Black","year":"2007","unstructured":"Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809\u20131822. https:\/\/doi.org\/10.1056\/NEJMoa067312","journal-title":"N Engl J Med"},{"issue":"2","key":"9_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","volume":"473","author":"BF Boyce","year":"2008","unstructured":"Boyce BF, Xing L (2008) Functions of RANKL\/RANK\/OPG in bone modeling and remodeling. Arch Biochem Biophys 473(2):139\u2013146. https:\/\/doi.org\/10.1016\/j.abb.2008.03.018","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"9_CR13","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1902\/jop.2007.060436","volume":"78","author":"RM Brennan","year":"2007","unstructured":"Brennan RM, Genco RJ, Wilding GE, Hovey KM, Trevisan M, Wactawski-Wende J (2007) Bacterial species in subgingival plaque and Oral bone loss in postmenopausal women. J Periodontol 78(6):1051\u20131061. https:\/\/doi.org\/10.1902\/jop.2007.060436","journal-title":"J Periodontol"},{"key":"9_CR14","doi-asserted-by":"publisher","unstructured":"Caggiano M, Gasparro R, D\u2019Ambrosio F, Pisano M, Di Palo MP, Contaldo M (2022) Smoking cessation on periodontal and Peri-implant health status: a systematic review. Dentis J 10(9). https:\/\/doi.org\/10.3390\/dj10090162","DOI":"10.3390\/dj10090162"},{"issue":"4","key":"9_CR15","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/jre.12022","volume":"48","author":"A Canabarro","year":"2013","unstructured":"Canabarro A, Valle C, Farias MR, Santos FB, Lazera M, Wanke B (2013) Association of subgingival colonization of Candida albicans and other yeasts with severity of chronic periodontitis. J Periodontal Res 48(4):428\u2013432. https:\/\/doi.org\/10.1111\/jre.12022","journal-title":"J Periodontal Res"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/jcpe.12935","volume":"45","author":"G Caton","year":"2018","unstructured":"Caton G et al (2018) A new classification scheme for periodontal and peri-implant diseases and conditions \u2013 introduction and key changes from the 1999 classification. J Clin Periodontol 45:S1\u2013S8. https:\/\/doi.org\/10.1111\/jcpe.12935","journal-title":"J Clin Periodontol"},{"issue":"1","key":"9_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1600-0757.2006.00178.x","volume":"43","author":"ILC Chapple","year":"2007","unstructured":"Chapple ILC, Matthews JB (2007) The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 43(1):160\u2013232. https:\/\/doi.org\/10.1111\/j.1600-0757.2006.00178.x","journal-title":"Periodontol"},{"issue":"1","key":"9_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12905-017-0440-9","volume":"17","author":"J-K Choi","year":"2017","unstructured":"Choi J-K, Kim Y-T, Kweon H-I, Park E-C, Choi S-H, Lee J-H (2017) Effect of periodontitis on the development of osteoporosis: results from a nationwide population-based cohort study (2003-2013). BMC Womens Health 17(1):77. https:\/\/doi.org\/10.1186\/s12905-017-0440-9","journal-title":"BMC Womens Health"},{"key":"9_CR19","doi-asserted-by":"publisher","unstructured":"Chou H-H, Lu S-L, Wang S-T, Huang T-H, Chen SL-S (2021) The association between bone mineral density and periodontal disease in middle-aged adults. Int J Environ Res Public Health 18(6). https:\/\/doi.org\/10.3390\/ijerph18063321","DOI":"10.3390\/ijerph18063321"},{"key":"9_CR20","doi-asserted-by":"publisher","unstructured":"Contaldo M (2023) Use of probiotics for oral candidiasis: state of the art and perspective. A further step toward personalized medicine? Front Biosci (Elite Ed) 15(1). https:\/\/doi.org\/10.31083\/j.fbe1501006","DOI":"10.31083\/j.fbe1501006"},{"key":"9_CR21","doi-asserted-by":"publisher","unstructured":"Contaldo M, Boccellino M, Zannini G, Romano A, Sciarra A, Sacco A, Settembre G, Coppola M, Di Carlo A, D\u2019Angelo L, Inchingolo F, Feola A, Di Domenico M (2020a) Sex hormones and inflammation role in oral cancer progression: a molecular and biological point of view. J Oncol 2020. https:\/\/doi.org\/10.1155\/2020\/9587971","DOI":"10.1155\/2020\/9587971"},{"key":"9_CR22","doi-asserted-by":"publisher","unstructured":"Contaldo M, Itro A, Lajolo C, Gioco G, Inchingolo F, Serpico R (2020b) Overview on osteoporosis, periodontitis and oral dysbiosis: the emerging role of oral microbiota. Appl Sci (Switzerland) 10(17). https:\/\/doi.org\/10.3390\/app10176000","DOI":"10.3390\/app10176000"},{"key":"9_CR23","doi-asserted-by":"publisher","unstructured":"Contaldo M, Lucchese A, Romano A, Vella FD, Di Stasio D, Serpico R, Petruzzi M (2021) Oral microbiota features in subjects with down syndrome and periodontal diseases: a systematic review. Int J Mol Sci 22(17). https:\/\/doi.org\/10.3390\/ijms22179251","DOI":"10.3390\/ijms22179251"},{"key":"9_CR24","doi-asserted-by":"publisher","first-page":"1415265","DOI":"10.3389\/fphar.2024.1415265","volume":"15","author":"J Cui","year":"2024","unstructured":"Cui J, Lin L, Hao F, Shi Z, Gao Y, Yang T, Yang C, Wu X, Gao R, Ru Y, Li F, Xiao C, Gao Y, Wang Y (2024) Comprehensive review of the traditional uses and the potential benefits of epimedium folium. Front Pharmacol 15:1415265. https:\/\/doi.org\/10.3389\/fphar.2024.1415265","journal-title":"Front Pharmacol"},{"issue":"12","key":"9_CR25","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1093\/rheumatology\/kez302","volume":"58","author":"M Das","year":"2019","unstructured":"Das M, Cronin O, Keohane DM, Cormac EM, Nugent H, Nugent M, Molloy C, O\u2019Toole PW, Shanahan F, Molloy MG, Jeffery IB (2019) Gut microbiota alterations associated with reduced bone mineral density in older adults. Rheumatology 58(12):2295\u20132304. https:\/\/doi.org\/10.1093\/rheumatology\/kez302","journal-title":"Rheumatology"},{"issue":"7","key":"9_CR26","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/GME.0000000000000830","volume":"24","author":"J de Passos-Soares","year":"2017","unstructured":"de Passos-Soares J et al (2017) Association between osteoporosis treatment and severe periodontitis in postmenopausal women. Menop 24(7):789\u2013795. https:\/\/doi.org\/10.1097\/GME.0000000000000830","journal-title":"Menop"},{"issue":"18","key":"9_CR27","doi-asserted-by":"publisher","first-page":"9135","DOI":"10.3390\/app12189135","volume":"12","author":"F Di Spirito","year":"2022","unstructured":"Di Spirito F, Amato A, Romano A, Dipalma G, Xhajanka E, Baroni A, Serpico R, Inchingolo F, Contaldo M (2022) Analysis of risk factors of oral cancer and periodontitis from a sex- and gender-related perspective: gender dentistry. Appl Sci (Switzerland) 12(18):9135. https:\/\/doi.org\/10.3390\/app12189135","journal-title":"Appl Sci (Switzerland)"},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","volume":"51","author":"WB Ershler","year":"2000","unstructured":"Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245\u2013270. https:\/\/doi.org\/10.1146\/annurev.med.51.1.245","journal-title":"Annu Rev Med"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","volume":"123","author":"V Fischer","year":"2022","unstructured":"Fischer V, Haffner-Luntzer M (2022) Interaction between bone and immune cells: implications for postmenopausal osteoporosis. Semin Cell Dev Biol 123:14\u201321. https:\/\/doi.org\/10.1016\/j.semcdb.2021.05.014","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"9_CR30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/MED.0b013e32835bc703","volume":"20","author":"MD Gershon","year":"2013","unstructured":"Gershon MD (2013) 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabet Obes 20(1):14\u201321. https:\/\/doi.org\/10.1097\/MED.0b013e32835bc703","journal-title":"Curr Opin Endocrinol Diabet Obes"},{"issue":"1","key":"9_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/JPER.20-0029","volume":"92","author":"JA Gil-Montoya","year":"2021","unstructured":"Gil-Montoya JA, Garrido-Mart\u00ednez M, Barrios-Rodr\u00edguez R, Ramos-Garc\u00eda P, Lenouvel D, Montes-Castillo C, Mart\u00ednez-Ram\u00edrez MJ (2021) Association between low bone mineral density and periodontitis in generally healthy perimenopausal women. J Periodontol 92(1):95\u2013103. https:\/\/doi.org\/10.1002\/JPER.20-0029","journal-title":"J Periodontol"},{"issue":"1","key":"9_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1741-2358.2012.00643.x","volume":"30","author":"IS Gomes-Filho","year":"2013","unstructured":"Gomes-Filho IS, Oliveira TJS, Passos JS et al (2013) Effect of osteoporosis on periodontal therapy among post-menopausal women. Gerodontology 30(1):40\u201348. https:\/\/doi.org\/10.1111\/j.1741-2358.2012.00643.x","journal-title":"Gerodontology"},{"key":"9_CR33","doi-asserted-by":"publisher","unstructured":"Graves DT, Oates T, Garlet GP (2011) Review of osteoimmunology and the host response in endodontic and periodontal lesions. J Oral Microbiol 3(2011). https:\/\/doi.org\/10.3402\/jom.v3i0.5304","DOI":"10.3402\/jom.v3i0.5304"},{"issue":"3","key":"9_CR34","doi-asserted-by":"publisher","first-page":"370","DOI":"10.14219\/jada.archive.1996.0208","volume":"127","author":"F Grodstein","year":"1996","unstructured":"Grodstein F, Colditz GA, Stampfer MJ (1996) Post-menopausal hormone use and tooth loss: a prospective study. J Am Dent Assoc 127(3):370\u2013377. https:\/\/doi.org\/10.14219\/jada.archive.1996.0208","journal-title":"J Am Dent Assoc"},{"issue":"50","key":"9_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040837","volume":"103","author":"Y Guo","year":"2024","unstructured":"Guo Y, Ge X, Wang W, Wang R, Chen Q, Wang H (2024) Epimedium applied in the clinical treatment of osteoporosis patients with periodontitis. Medicine 103(50):e40837. https:\/\/doi.org\/10.1097\/MD.0000000000040837","journal-title":"Medicine"},{"issue":"3","key":"9_CR36","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1399-302X.2007.00411.x","volume":"23","author":"AD Haffajee","year":"2008","unstructured":"Haffajee AD, Socransky SS, Patel MR, Song X (2008) Microbial complexes in supragingival plaque. Oral Microbiol Immunol 23(3):196\u2013205. https:\/\/doi.org\/10.1111\/j.1399-302X.2007.00411.x","journal-title":"Oral Microbiol Immunol"},{"issue":"4","key":"9_CR37","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1600-0765.2008.01154.x","volume":"44","author":"AD Haffajee","year":"2009","unstructured":"Haffajee AD, Teles RP, Patel MR, Song X, Veiga N, Socransky SS (2009) Factors affecting human supragingival biofilm composition. I. Plaque mass. J Periodontal Res 44(4):511\u2013519. https:\/\/doi.org\/10.1111\/j.1600-0765.2008.01154.x","journal-title":"J Periodontal Res"},{"issue":"2","key":"9_CR38","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1902\/jop.2015.150365","volume":"87","author":"S Hern\u00e1ndez-Vigueras","year":"2016","unstructured":"Hern\u00e1ndez-Vigueras S, Mart\u00ednez-Garriga B, S\u00e1nchez MC, Sanz M, Estrugo-Devesa A, Vinuesa T, L\u00f3pez-L\u00f3pez J, Vi\u00f1as M (2016) Oral microbiota, periodontal status, and osteoporosis in postmenopausal females. J Periodontol 87(2):124\u2013133. https:\/\/doi.org\/10.1902\/jop.2015.150365","journal-title":"J Periodontol"},{"issue":"1\u20132","key":"9_CR39","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s11657-013-0136-1","volume":"8","author":"E Hernlund","year":"2013","unstructured":"Hernlund E, Svedbom A, Iverg\u00e5rd M, Compston J, Cooper C, Stenmark J, McCloskey EV, J\u00f6nsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. Arch Osteoporos 8(1\u20132):136. https:\/\/doi.org\/10.1007\/s11657-013-0136-1","journal-title":"Arch Osteoporos"},{"key":"9_CR40","doi-asserted-by":"publisher","unstructured":"Holmstrup P, Damgaard C, Olsen I, Klinge B, Flyvbjerg A, Nielsen CH, Hansen PR (2017) Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician. J Oral Microbiol 9(1). https:\/\/doi.org\/10.1080\/20002297.2017.1332710","DOI":"10.1080\/20002297.2017.1332710"},{"issue":"1","key":"9_CR41","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12903-021-01496-1","volume":"21","author":"S-J Hong","year":"2021","unstructured":"Hong S-J, Yang B-E, Yoo D-M, Kim S-J, Choi H-G, Byun S-H (2021) Analysis of the relationship between periodontitis and osteoporosis\/fractures: a cross-sectional study. BMC Oral Health 21(1):125. https:\/\/doi.org\/10.1186\/s12903-021-01496-1","journal-title":"BMC Oral Health"},{"issue":"3","key":"9_CR42","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.joca.2023.11.016","volume":"32","author":"SR Hoy","year":"2024","unstructured":"Hoy SR, Vucetich JA, Vucetich LM, Hindelang M, Huebner JL, Kraus VB, Peterson RO (2024) Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population. Osteoarthr Cartil 32(3):281\u2013286. https:\/\/doi.org\/10.1016\/j.joca.2023.11.016","journal-title":"Osteoarthr Cartil"},{"key":"9_CR43","doi-asserted-by":"publisher","unstructured":"Hu W, Chen S, Zou X, Chen Y, Luo J, Zhong P, Ma D (2024a) Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine. J Adv Res 73. https:\/\/doi.org\/10.1016\/j.jare.2024.08.019","DOI":"10.1016\/j.jare.2024.08.019"},{"issue":"50","key":"9_CR44","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040768","volume":"103","author":"W Hu","year":"2024","unstructured":"Hu W, Feng X, Wen C (2024b) Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: findings from NHANES. Medicine 103(50):e40768. https:\/\/doi.org\/10.1097\/MD.0000000000040768","journal-title":"Medicine"},{"issue":"6","key":"9_CR45","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002348","volume":"95","author":"Y-F Huang","year":"2016","unstructured":"Huang Y-F, Chang C-T, Liu S-P, Muo C-H, Tsai C-H, Hong H-H, Shen Y-F, Wu C-Z (2016) The impact of Oral hygiene maintenance on the association between periodontitis and osteoporosis: a Nationwide population-based cross sectional study. Medicine 95(6):e2348. https:\/\/doi.org\/10.1097\/MD.0000000000002348","journal-title":"Medicine"},{"issue":"1","key":"9_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00223-004-0275-x","volume":"77","author":"K Inagaki","year":"2005","unstructured":"Inagaki K, Kurosu Y, Yoshinari N, Noguchi T, Krall EA, Garcia RI (2005) Efficacy of periodontal disease and tooth loss to screen for low bone mineral density in Japanese women. Calcif Tissue Int 77(1):9\u201314. https:\/\/doi.org\/10.1007\/s00223-004-0275-x","journal-title":"Calcif Tissue Int"},{"key":"9_CR47","doi-asserted-by":"publisher","unstructured":"Inchingolo F, Martelli FS, Isacco CG, Borsani E, Cantore S, Corcioli F, Boddi A, Nguy\u00ean KCD, De Vito D, Aityan SK, Dipalma G, Ballini A (2020) Chronic periodontitis and immunity, towards the implementation of a personalized medicine: a translational research on gene single nucleotide polymorphisms (SNPs) linked to chronic oral dysbiosis in 96 caucasian patients. Biomedicine 8(5). https:\/\/doi.org\/10.3390\/BIOMEDICINES8050115","DOI":"10.3390\/BIOMEDICINES8050115"},{"issue":"11","key":"9_CR48","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.37358\/RC.17.11.5927","volume":"68","author":"M Ionas","year":"2017","unstructured":"Ionas M, Mitariu SIC, Dancila A, Ionas TH, Comaneanu RM, Botoaca O, Mitariu MMC (2017) The capacity of a specific anti-streptococcus Mutans monoclonal antibodies test to identify the diabetic patients with increased risk of periodontal disease. Rev Chim 68(11):2556\u20132559","journal-title":"Rev Chim"},{"key":"9_CR49","doi-asserted-by":"publisher","first-page":"S219","DOI":"10.1111\/jcpe.12951","volume":"45","author":"S Jepsen","year":"2018","unstructured":"Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, West NX, Yamazaki K (2018a) Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions. J Clin Periodontol 45:S219\u2013S229. https:\/\/doi.org\/10.1111\/jcpe.12951","journal-title":"J Clin Periodontol"},{"key":"9_CR50","doi-asserted-by":"publisher","first-page":"S237","DOI":"10.1002\/JPER.17-0733","volume":"89","author":"S Jepsen","year":"2018","unstructured":"Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, West NX, Yamazaki K (2018b) Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 world workshop on the classification of periodontal and Peri-implant diseases and conditions. J Periodontol 89:S237\u2013S248. https:\/\/doi.org\/10.1002\/JPER.17-0733","journal-title":"J Periodontol"},{"issue":"12","key":"9_CR51","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726\u20131733. https:\/\/doi.org\/10.1007\/s00198-006-0172-4","journal-title":"Osteoporos Int"},{"key":"9_CR52","unstructured":"Kanis JA (2007). Assessment of osteoporosis at the primary health-care level. Technical Report. World Health Organization Collaborating Centre for Metabolic Bone Diseases (Printed by the University of Sheffield., Ed.; 2007th ed.). University of Sheffield"},{"issue":"4","key":"9_CR53","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00198-008-0560-z","volume":"19","author":"JA Kanis","year":"2008","unstructured":"Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster J-Y, Borgstrom F, Rizzoli R (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19(4):399\u2013428. https:\/\/doi.org\/10.1007\/s00198-008-0560-z","journal-title":"Osteoporos Int"},{"issue":"11","key":"9_CR54","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Bernab\u00e9 E, Dahiya M, Bhandari B, Murray CJL, Marcenes W (2014) Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res 93(11):1045\u20131053. https:\/\/doi.org\/10.1177\/0022034514552491","journal-title":"J Dent Res"},{"issue":"1","key":"9_CR55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00784-023-05463-8","volume":"28","author":"P Khunthananithi","year":"2023","unstructured":"Khunthananithi P, Lertpimonchai A, Sritara C, Srithanyarat SS, Thienpramuk L, Mongkornkarn S (2023) Decreased bone mineral density is associated with an increased number of teeth with periodontitis progression: a 5-year retrospective cohort study. Clin Oral Investig 28(1):51. https:\/\/doi.org\/10.1007\/s00784-023-05463-8","journal-title":"Clin Oral Investig"},{"issue":"3","key":"9_CR56","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.0902-0055.2004.00139.x","volume":"19","author":"J Kido","year":"2004","unstructured":"Kido J, Kido R et al (2004) Induction of calprotectin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophils. Oral Microbiol Immunol 19(3):182\u2013187. https:\/\/doi.org\/10.1111\/j.0902-0055.2004.00139.x","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"9_CR57","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/prd.12333","volume":"84","author":"PS Kumar","year":"2020","unstructured":"Kumar PS (2020) Interventions to prevent periodontal disease in tobacco-, alcohol-, and drug-dependent individuals. Periodontol 84(1):84\u2013101. https:\/\/doi.org\/10.1111\/prd.12333","journal-title":"Periodontol"},{"issue":"1","key":"9_CR58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11657-024-01382-7","volume":"19","author":"B Lai","year":"2024","unstructured":"Lai B, Jiang H, Gao R, Zhou X (2024) Association between alcohol intake and bone mineral density: results from the NHANES 2005-2020 and two-sample Mendelian randomization. Arch Osteoporos 19(1):21. https:\/\/doi.org\/10.1007\/s11657-024-01382-7","journal-title":"Arch Osteoporos"},{"issue":"5","key":"9_CR59","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/cdoe.12812","volume":"51","author":"H Larvin","year":"2023","unstructured":"Larvin H, Kang J, Aggarwal VR, Pavitt S, Wu J (2023) Periodontitis and risk of immune-mediated systemic conditions: a systematic review and meta-analysis. Community Dent Oral Epidemiol 51(5):705\u2013717. https:\/\/doi.org\/10.1111\/cdoe.12812","journal-title":"Community Dent Oral Epidemiol"},{"issue":"11","key":"9_CR60","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.adaj.2024.08.009","volume":"155","author":"JM Latimer","year":"2024","unstructured":"Latimer JM, Travan S, Berkey FD, Sugai JV, Giannobile WV (2024) Physician-dentist dual referral model concept for coordinated bone anabolic therapy. J Am Dent Assoc 155(11):954\u2013962. https:\/\/doi.org\/10.1016\/j.adaj.2024.08.009","journal-title":"J Am Dent Assoc"},{"key":"9_CR61","doi-asserted-by":"publisher","unstructured":"Lee J-H, Jeong S-N (2020) A population-based study on the association between periodontal disease and major lifestyle-related comorbidities in South Korea: an elderly cohort study from 2002\u20132015. Medicina 56(11). https:\/\/doi.org\/10.3390\/medicina56110575","DOI":"10.3390\/medicina56110575"},{"issue":"26","key":"9_CR62","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007398","volume":"96","author":"J-H Lee","year":"2017","unstructured":"Lee J-H, Oh J-Y, Youk T-M, Jeong S-N, Kim Y-T, Choi S-H (2017) Association between periodontal disease and non-communicable diseases: a 12-year longitudinal health-examinee cohort study in South Korea. Medicine 96(26):e7398. https:\/\/doi.org\/10.1097\/MD.0000000000007398","journal-title":"Medicine"},{"issue":"7","key":"9_CR63","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/154405910608500704","volume":"85","author":"UH Lerner","year":"2006","unstructured":"Lerner UH (2006) Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 85(7):596\u2013607. https:\/\/doi.org\/10.1177\/154405910608500704","journal-title":"J Dent Res"},{"key":"9_CR64","doi-asserted-by":"publisher","unstructured":"Li X, Wen M, Xu Y, Shen Y, Yang X (2022) The association of healthy eating index with periodontitis in NHANES 2013\u20132014. Front Nutr 9. https:\/\/doi.org\/10.3389\/fnut.2022.968073","DOI":"10.3389\/fnut.2022.968073"},{"issue":"5","key":"9_CR65","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3892\/ijmm.2013.1485","volume":"32","author":"W Liang","year":"2013","unstructured":"Liang W, Li X, Li Y, Li C, Gao B, Gan H, Li S, Shen J, Kang J, Ding S, Lin X, Liao L (2013) Tongue coating microbiome regulates the changes in tongue texture and coating in patients with post-menopausal osteoporosis of Gan-shen deficiency syndrome type. Int J Mol Med 32(5):1069\u20131076. https:\/\/doi.org\/10.3892\/ijmm.2013.1485","journal-title":"Int J Mol Med"},{"issue":"7","key":"9_CR66","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000553","volume":"94","author":"T-H Lin","year":"2015","unstructured":"Lin T-H, Lung C-C, Su H-P, Huang J-Y, Ko P-C, Jan S-R, Sun Y-H, Nfor ON, Tu H-P, Chang C-S, Jian Z-H, Chiang Y-C, Liaw Y-P (2015) Association between periodontal disease and osteoporosis by gender: a nationwide population-based cohort study. Medicine 94(7):e553. https:\/\/doi.org\/10.1097\/MD.0000000000000553","journal-title":"Medicine"},{"key":"9_CR67","volume-title":"Microbiology of dental decay and periodontal disease","author":"WJ Loesche","year":"1996","unstructured":"Loesche WJ (1996) In: Baron S (ed) Microbiology of dental decay and periodontal disease. University of Texas Medical Branch"},{"issue":"2","key":"9_CR68","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1177\/0300985815612154","volume":"53","author":"LJ Lowenstine","year":"2016","unstructured":"Lowenstine LJ, McManamon R, Terio KA (2016) Comparative pathology of aging great apes: bonobos, chimpanzees, gorillas, and orangutans. Vet Pathol 53(2):250\u2013276. https:\/\/doi.org\/10.1177\/0300985815612154","journal-title":"Vet Pathol"},{"key":"9_CR69","doi-asserted-by":"publisher","unstructured":"Luo K, Ma S, Guo J, Huang Y, Yan F, Xiao Y (2014) Association between postmenopausal osteoporosis and experimental periodontitis. Biomed Res Int 2014. https:\/\/doi.org\/10.1155\/2014\/316134","DOI":"10.1155\/2014\/316134"},{"issue":"1","key":"9_CR70","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1186\/s12891-024-07904-1","volume":"25","author":"Z Ma","year":"2024","unstructured":"Ma Z, Liu Y, Shen W, Yang J, Wang T, Li Y, Ma J, Zhang X, Wang H (2024) Osteoporosis in postmenopausal women is associated with disturbances in gut microbiota and migration of peripheral immune cells. BMC Musculoskelet Disord 25(1):791. https:\/\/doi.org\/10.1186\/s12891-024-07904-1","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"9_CR71","first-page":"214","volume":"24","author":"BC Manjunath","year":"2011","unstructured":"Manjunath BC, Praveen K, Chandrashekar BR, Rani RMV, Bhalla A (2011) Periodontal infections: a risk factor for various systemic diseases. Natl Med J India 24(4):214\u2013219","journal-title":"Natl Med J India"},{"issue":"4","key":"9_CR72","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/10550887.2023.2264999","volume":"42","author":"K Masuko","year":"2024","unstructured":"Masuko K, Iwahara C, Kamiya S, Sakate S, Mizukami Y (2024) Levels of vitamin D and a bone resorption marker in the sera of young women with alcohol use disorder. J Addict Dis 42(4):447\u2013455. https:\/\/doi.org\/10.1080\/10550887.2023.2264999","journal-title":"J Addict Dis"},{"issue":"3","key":"9_CR73","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ogc.2019.04.008","volume":"46","author":"MJ Minkin","year":"2019","unstructured":"Minkin MJ (2019) Menopause: hormones, lifestyle, and optimizing aging. Obstet Gynecol Clin N Am 46(3):501\u2013514. https:\/\/doi.org\/10.1016\/j.ogc.2019.04.008","journal-title":"Obstet Gynecol Clin N Am"},{"issue":"1","key":"9_CR74","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/prd.12147","volume":"76","author":"A Mombelli","year":"2018","unstructured":"Mombelli A (2018) Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontol 76(1):85\u201396. https:\/\/doi.org\/10.1111\/prd.12147","journal-title":"Periodontol"},{"key":"9_CR75","doi-asserted-by":"publisher","unstructured":"Narayanan A, S\u00f6der B, Meurman J, Lundmark A, Hu YOO, Neogi U, Yucel-Lindberg T (2023) Composition of subgingival microbiota associated with periodontitis and diagnosis of malignancy \u2013 a cross-sectional study. Front Microbiol 14. https:\/\/doi.org\/10.3389\/fmicb.2023.1172340","DOI":"10.3389\/fmicb.2023.1172340"},{"issue":"6","key":"9_CR76","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/00007611-200106000-00005","volume":"94","author":"NIH Consensus Development Panel on Osteoporosis Prevention","year":"2001","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention (2001) Diagnosis, and therapy, march 7-29, 2000: highlights of the conference. South Med J 94(6):569\u2013573. https:\/\/doi.org\/10.1097\/00007611-200106000-00005","journal-title":"South Med J"},{"issue":"2","key":"9_CR77","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4103\/ijdr.ijdr_522_21","volume":"35","author":"J Pavithra","year":"2024","unstructured":"Pavithra J, Ramesh A, Thomas B, Kumari NS, Sharmila KP (2024) Salivary calprotectin levels and bone mineral density in post-menopausal women with and without chronic periodontitis \u2013 an evaluative study. Indian J Dental Res 35(2):140\u2013144. https:\/\/doi.org\/10.4103\/ijdr.ijdr_522_21","journal-title":"Indian J Dental Res"},{"key":"9_CR78","doi-asserted-by":"publisher","unstructured":"Peng J, Chen J, Liu Y, Lyu J, Zhang B (2023) Association between periodontitis and osteoporosis in United States adults from the National Health and nutrition examination survey: a cross-sectional analysis. BMC Oral Health 23(1). https:\/\/doi.org\/10.1186\/s12903-023-02990-4","DOI":"10.1186\/s12903-023-02990-4"},{"issue":"5","key":"9_CR79","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s00198-015-3437-y","volume":"27","author":"DC Penoni","year":"2016","unstructured":"Penoni DC, Torres SR, Farias MLF, Fernandes TM, Luiz RR, Le\u00e3o ATT (2016) Association of osteoporosis and bone medication with the periodontal condition in elderly women. Osteoporos Int 27(5):1887\u20131896. https:\/\/doi.org\/10.1007\/s00198-015-3437-y","journal-title":"Osteoporos Int"},{"issue":"3","key":"9_CR80","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1177\/0022034516682017","volume":"96","author":"DC Penoni","year":"2017","unstructured":"Penoni DC, Fidalgo TKS, Torres SR, Varela VM, Masterson D, Le\u00e3o ATT, Maia LC (2017) Bone density and clinical periodontal attachment in postmenopausal women: a systematic review and meta-analysis. J Dent Res 96(3):261\u2013269. https:\/\/doi.org\/10.1177\/0022034516682017","journal-title":"J Dent Res"},{"issue":"4","key":"9_CR81","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1601-0825.2011.01881.x","volume":"18","author":"E Pepelassi","year":"2012","unstructured":"Pepelassi E, Nicopoulou-Karayianni K, Archontopoulou AD, Mitsea A, Kavadella A, Tsiklakis K, Vrotsos I, Devlin H, Horner K (2012) The relationship between osteoporosis and periodontitis in women aged 45-70years. Oral Dis 18(4):353\u2013359. https:\/\/doi.org\/10.1111\/j.1601-0825.2011.01881.x","journal-title":"Oral Dis"},{"key":"9_CR82","doi-asserted-by":"publisher","unstructured":"Pestana de Vasconcelos N, Martins IS, Afonso AS, Braga AC, Pina-Vaz I (2024) Osteoporosis and apical periodontitis prevalence: a systematic review. Dentis J 12(8). https:\/\/doi.org\/10.3390\/dj12080272","DOI":"10.3390\/dj12080272"},{"issue":"1","key":"9_CR83","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4103\/ijdr.ijdr_1192_21","volume":"34","author":"R Potdar","year":"2023","unstructured":"Potdar R, Ramesh A, Rajesh A (2023) Evaluation of salivary IL-8 and calcium levels in postmenopausal females with and without periodontitis-a comparative study. Indian J Dent Res 34(1):45\u201348. https:\/\/doi.org\/10.4103\/ijdr.ijdr_1192_21","journal-title":"Indian J Dent Res"},{"issue":"4","key":"9_CR84","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3892\/etm.2022.11179","volume":"23","author":"SA Preda","year":"2022","unstructured":"Preda SA, Comanescu MC, Albulescu DM, Dasc\u0103lu IT, Camen A, Cump\u0103t\u0103 CN, Perlea P, Bug\u0103l\u0103 NM, Stoica EL, Gheorghi\u021b\u0103 LM, Diaconu OA, Tuculina MJ (2022) Correlations between periodontal indices and osteoporosis. Exp Ther Med 23(4):254. https:\/\/doi.org\/10.3892\/etm.2022.11179","journal-title":"Exp Ther Med"},{"key":"9_CR85","doi-asserted-by":"publisher","unstructured":"Qi J, Chen J, Pang Y, Guo Y, Chen G, Liu Y, Wang J, Liu E (2023) Association between periodontal disease and osteoporosis in postmenopausal women: a systematic review and meta-analysis. Heliyon 9(11). https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20922","DOI":"10.1016\/j.heliyon.2023.e20922"},{"issue":"8","key":"9_CR86","doi-asserted-by":"publisher","first-page":"888","DOI":"10.6026\/973206300200888","volume":"20","author":"D Saini","year":"2024","unstructured":"Saini D, Dhawan S, Dhawan R, Gupta P, Kiranmayi J, Singh R (2024) Prevalence of co-morbidities among periodontitis and non-periodontitis Indian patients. Bioinformation 20(8):888\u2013892. https:\/\/doi.org\/10.6026\/973206300200888","journal-title":"Bioinformation"},{"issue":"3","key":"9_CR87","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jcpe.13189","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Marco del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D\u2019Aiuto F, Bouchard P, Chapple I, Dietrich T, Gotsman I, Graziani F, Vlachopoulos C, Wimmer G (2020) Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol 47(3):268\u2013288. https:\/\/doi.org\/10.1111\/jcpe.13189","journal-title":"J Clin Periodontol"},{"issue":"2","key":"9_CR88","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3290\/j.qi.b4867855","volume":"55","author":"P Sharma","year":"2024","unstructured":"Sharma P, Sharma RK, Tewari S, Gill PS, Tanwar N, Arora R, Kaur M (2024) Impact of subgingival instrumentation on systemic inflammation and serum bone resorption marker in premenopausal women with periodontitis: a prospective interventional study. Quintessence Int 55(2):108\u2013118. https:\/\/doi.org\/10.3290\/j.qi.b4867855","journal-title":"Quintessence Int"},{"issue":"3","key":"9_CR89","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4103\/jmh.jmh_125_24","volume":"15","author":"S Shrivastava","year":"2024","unstructured":"Shrivastava S (2024) Menopause and oral health: clinical implications and preventive strategies. J Mid-Life Health 15(3):135\u2013141. https:\/\/doi.org\/10.4103\/jmh.jmh_125_24","journal-title":"J Mid-Life Health"},{"key":"9_CR90","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397166-1.00008-4","volume-title":"The Parathyroids: basic and clinical concepts","author":"BC Silva","year":"2015","unstructured":"Silva BC, Kousteni S (2015) Cellular actions of PTH: osteoblasts, osteoclasts, and osteocytes. In: The Parathyroids: basic and clinical concepts, 3rd edn. https:\/\/doi.org\/10.1016\/B978-0-12-397166-1.00008-4","edition":"3"},{"issue":"S22","key":"9_CR91","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/jcpe.13275","volume":"47","author":"DE Slot","year":"2020","unstructured":"Slot DE, Valkenburg C, Van der Weijden GA (2020) Mechanical plaque removal of periodontal maintenance patients: a systematic review and network meta-analysis. J Clin Periodontol 47(S22):107\u2013124. https:\/\/doi.org\/10.1111\/jcpe.13275","journal-title":"J Clin Periodontol"},{"issue":"2","key":"9_CR92","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25(2):134\u2013144. https:\/\/doi.org\/10.1111\/j.1600-051X.1998.tb02419.x","journal-title":"J Clin Periodontol"},{"issue":"1","key":"9_CR93","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","volume":"4","author":"T Sozen","year":"2017","unstructured":"Sozen T, Ozisik L, Calik Basaran N (2017) An overview and management of osteoporosis. Eur J Rheumatol 4(1):46\u201356. https:\/\/doi.org\/10.5152\/eurjrheum.2016.048","journal-title":"Eur J Rheumatol"},{"issue":"1","key":"9_CR94","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1902\/jop.2017.170333","volume":"89","author":"M Sperr","year":"2018","unstructured":"Sperr M, Kundi M, Tursic V, Bristela M, Moritz A, Andrukhov O, Rausch-Fan X, Sperr WR (2018) Prevalence of comorbidities in periodontitis patients compared with the general Austrian population. J Periodontol 89(1):19\u201327. https:\/\/doi.org\/10.1902\/jop.2017.170333","journal-title":"J Periodontol"},{"issue":"7","key":"9_CR95","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrgastro.2017.51","volume":"14","author":"SN Spohn","year":"2017","unstructured":"Spohn SN, Mawe GM (2017) Non-conventional features of peripheral serotonin signalling \u2013 the gut and beyond. Nat Rev Gastroenterol Hepatol 14(7):412\u2013420. https:\/\/doi.org\/10.1038\/nrgastro.2017.51","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"9_CR96","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jocd.2020.02.001","volume":"24","author":"E Tabor","year":"2021","unstructured":"Tabor E, H\u0171psch H, Rokicka J, Sierpi\u0144ska T, Konstantynowicz J, Orywal K, Pluskiewicz W (2021) Salivary content might be associated with skeletal status in postmenopausal women: SilesiaOsteoActive study results. J Clin Densitom 24(1):14\u201321. https:\/\/doi.org\/10.1016\/j.jocd.2020.02.001","journal-title":"J Clin Densitom"},{"key":"9_CR97","doi-asserted-by":"publisher","unstructured":"Ticinesi A, Siniscalchi C, Meschi T, Nouvenne A (2024) Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies. Osteoporos Int 36. https:\/\/doi.org\/10.1007\/s00198-024-07320-0","DOI":"10.1007\/s00198-024-07320-0"},{"key":"9_CR98","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1002\/JPER.18-0006","volume":"89","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol 89:S159\u2013S172. https:\/\/doi.org\/10.1002\/JPER.18-0006","journal-title":"J Periodontol"},{"issue":"5","key":"9_CR99","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/jcpe.13769","volume":"50","author":"D Trindade","year":"2023","unstructured":"Trindade D, Carvalho R, Machado V, Chambrone L, Mendes JJ, Botelho J (2023) Prevalence of periodontitis in dentate people between 2011 and 2020: a systematic review and meta-analysis of epidemiological studies. J Clin Periodontol 50(5):604\u2013626. https:\/\/doi.org\/10.1111\/jcpe.13769","journal-title":"J Clin Periodontol"},{"issue":"7","key":"9_CR100","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1600-051X.2011.01730.x","volume":"38","author":"NG Uzel","year":"2011","unstructured":"Uzel NG, Teles FR, Teles RP, Song XQ, Torresyap G, Socransky SS, Haffajee AD (2011) Microbial shifts during dental biofilm re-development in the absence of oral hygiene in periodontal health and disease. J Clin Periodontol 38(7):612\u2013620. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01730.x","journal-title":"J Clin Periodontol"},{"issue":"12","key":"9_CR101","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s40618-024-02402-6","volume":"47","author":"A Vergatti","year":"2024","unstructured":"Vergatti A, Abate V, D\u2019Elia L, De Filippo G, Piccinocchi G, Gennari L, Merlotti D, Galletti F, Strazzullo P, Rendina D (2024) Smoking habits and osteoporosis in community-dwelling men subjected to dual-X-ray absorptiometry: a cross-sectional study. J Endocrinol Investig 47(12):3129\u20133135. https:\/\/doi.org\/10.1007\/s40618-024-02402-6","journal-title":"J Endocrinol Investig"},{"key":"9_CR102","doi-asserted-by":"publisher","first-page":"1487998","DOI":"10.3389\/fendo.2024.1487998","volume":"15","author":"F Wang","year":"2024","unstructured":"Wang F, Wei W, Liu PJ (2024) Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis. Front Endocrinol 15:1487998. https:\/\/doi.org\/10.3389\/fendo.2024.1487998","journal-title":"Front Endocrinol"},{"key":"9_CR103","doi-asserted-by":"publisher","unstructured":"Wei M, Li C, Dai Y, Zhou H, Cui Y, Zeng Y, Huang Q, Wang Q (2021) High-throughput absolute quantification sequencing revealed osteoporosis-related gut microbiota alterations in Han Chinese elderly. Front Cell Infect Microbiol 11. https:\/\/doi.org\/10.3389\/fcimb.2021.630372","DOI":"10.3389\/fcimb.2021.630372"},{"issue":"5","key":"9_CR104","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1172\/JCI28550","volume":"116","author":"MN Weitzmann","year":"2006","unstructured":"Weitzmann MN, Pacifici R (2006) Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116(5):1186\u20131194. https:\/\/doi.org\/10.1172\/JCI28550","journal-title":"J Clin Invest"},{"key":"9_CR105","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X2024e12951","volume":"57","author":"J Wu","year":"2024","unstructured":"Wu J, Yao L, Liu Y, Zhang S, Wang K (2024) Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis. Braz J Med Biol Res 57:e12951. https:\/\/doi.org\/10.1590\/1414-431X2024e12951","journal-title":"Braz J Med Biol Res"},{"issue":"10","key":"9_CR106","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s00198-022-06454-3","volume":"33","author":"P-L Xiao","year":"2022","unstructured":"Xiao P-L, Cui A-Y, Hsu C-J, Peng R, Jiang N, Xu X-H, Ma Y-G, Liu D, Lu H-D (2022) Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int 33(10):2137\u20132153. https:\/\/doi.org\/10.1007\/s00198-022-06454-3","journal-title":"Osteoporos Int"},{"issue":"2","key":"9_CR107","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/odi.13531","volume":"27","author":"S Xu","year":"2021","unstructured":"Xu S, Zhang G, Guo J-F, Tan Y-H (2021) Associations between osteoporosis and risk of periodontitis: a pooled analysis of observational studies. Oral Dis 27(2):357\u2013369. https:\/\/doi.org\/10.1111\/odi.13531","journal-title":"Oral Dis"},{"issue":"11","key":"9_CR108","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.62347\/GXEB5902","volume":"16","author":"G Xu","year":"2024","unstructured":"Xu G, Guo Y, Wang W, Yu W-Q, Chen Q-M, Wang H (2024) Zoledronic acid improves periodontal health, reduces serum inflammation, and enhances bone metabolism in postmenopausal osteoporosis complicated by periodontitis. Am J Transl Res 16(11):6519\u20136527. https:\/\/doi.org\/10.62347\/GXEB5902","journal-title":"Am J Transl Res"},{"issue":"1","key":"9_CR109","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/prd.12422","volume":"89","author":"B Yu","year":"2022","unstructured":"Yu B, Wang C (2022) Osteoporosis and periodontal diseases\u2014an update on their association and mechanistic links. Periodontol 89(1):99\u2013113. https:\/\/doi.org\/10.1111\/prd.12422","journal-title":"Periodontol"},{"issue":"3","key":"9_CR110","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1111\/odi.14582","volume":"30","author":"Y Yu","year":"2024","unstructured":"Yu Y, Chu T, Dong J, Deng H, Pan Y, Wang Y (2024) A Mendelian randomization study on the association of bone mineral density with periodontitis. Oral Dis 30(3):1488\u20131496. https:\/\/doi.org\/10.1111\/odi.14582","journal-title":"Oral Dis"},{"issue":"4","key":"9_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2024.101523","volume":"27","author":"F Zarzour","year":"2024","unstructured":"Zarzour F, Leslie WD (2024) The effect of smoking cessation versus current smoking on fracture risk: the Manitoba BMD registry. J Clin Densitom 27(4):101523. https:\/\/doi.org\/10.1016\/j.jocd.2024.101523","journal-title":"J Clin Densitom"},{"issue":"1","key":"9_CR112","doi-asserted-by":"publisher","first-page":"2437247","DOI":"10.1080\/19490976.2024.2437247","volume":"17","author":"X-Q Zheng","year":"2025","unstructured":"Zheng X-Q, Wang D-B, Jiang Y-R, Song C-L (2025) Gut microbiota and microbial metabolites for osteoporosis. Gut Microbes 17(1):2437247. https:\/\/doi.org\/10.1080\/19490976.2024.2437247","journal-title":"Gut Microbes"},{"key":"9_CR113","doi-asserted-by":"publisher","unstructured":"Zhou Y, Zhu Y, Jin X, Zhang Y, Song J, Wu Z, Li Y, Yi J, Wang D, Hu M (2023) Chroogomphus rutilus regulates bone metabolism to prevent periodontal bone loss during orthodontic tooth movement in osteoporotic rats. Nutrients 15(23). https:\/\/doi.org\/10.3390\/nu15234906","DOI":"10.3390\/nu15234906"}],"container-title":["Advances in Experimental Medicine and Biology","Oral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03176-1_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:34:01Z","timestamp":1784295241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03176-1_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"ISBN":["9783032031754","9783032031761"],"references-count":113,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03176-1_9","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"13 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}