{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:07:04Z","timestamp":1784275624107,"version":"3.55.0"},"publisher-location":"Cham","reference-count":23,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032033970","type":"print"},{"value":"9783032033987","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-03398-7_12","type":"book-chapter","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T14:49:45Z","timestamp":1763822985000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Management and Genetic Analysis of a Complex Case of Segmental Infantile Hemangioma with Subcutaneous Pelvic and Gluteal Tumefactions"],"prefix":"10.1007","author":[{"given":"Christos","family":"Yapijakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iphigenia","family":"Gintoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charikleia","family":"Kelaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Iordanoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Mirilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"12_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ad.2016.10.003","volume":"5","author":"X Calder\u00f3n-Castrat","year":"2017","unstructured":"Calder\u00f3n-Castrat X, Peceros-Escalante J, Vel\u00e1squez F, Lipa-Chancolla RM, Ballona R (2017) Segmental infantile hemangioma with minimal or arrested growth in LUMBAR syndrome. Actas Dermosifiliogr 5:475\u2013477","journal-title":"Actas Dermosifiliogr"},{"key":"12_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.730393","volume":"9","author":"A Diociaiuti","year":"2021","unstructured":"Diociaiuti A, Paolantonio G, Zama M, Alaggio R, Carnevale C, Conforti A, Cesario C, Dentici ML, Buonuomo PS, Rollo M, El Hachem M (2021) Vascular birthmarks as a clue for complex and syndromic vascular anomalies. Front Pediatr 9:730393","journal-title":"Front Pediatr"},{"issue":"6","key":"12_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.5546\/aap.2013.537","volume":"111","author":"A Giachetti","year":"2013","unstructured":"Giachetti A, Sojo MM, Garc\u00eda-M\u00f3naco R (2013) Hemangiomas infantiles [infantile hemangiomas]. Arch Argent Pediatr 111(6):537\u2013545","journal-title":"Arch Argent Pediatr"},{"issue":"16","key":"12_CR4","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1158\/1078-0432.CCR-11-0379","volume":"17","author":"DM Glubb","year":"2011","unstructured":"Glubb DM, Cerri E, Giese A, Zhang W, Mirza O, Thompson EE, Chen P, Das S, Jassem J, Rzyman W, Lingen MW, Salgia R, Hirsch FR, Dziadziuszko R, Ballmer-Hofer K, Innocenti F (2011) Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer. Clin Cancer Res 17(16):5257\u20135267","journal-title":"Clin Cancer Res"},{"issue":"4","key":"12_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.det.2022.06.004","volume":"40","author":"DJ Hasbani","year":"2022","unstructured":"Hasbani DJ, Hamie L (2022) Infantile Hemangiomas. Dermatol Clin 40(4):383\u2013392","journal-title":"Dermatol Clin"},{"issue":"6","key":"12_CR6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.3390\/children9060908","volume":"9","author":"RE Heredea","year":"2022","unstructured":"Heredea RE, Melnic E, Cirligeriu LE, Berzava PL, St\u0103nciulescu MC, Popoiu CM, Cimpean AM (2022) VEGF pathway gene expression profile of proliferating versus Involuting infantile hemangiomas: preliminary evidence and review of the literature. Children 9(6):908","journal-title":"Children"},{"issue":"2","key":"12_CR7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4172\/2469-9853.1000148","volume":"4","author":"M Jauhri","year":"2017","unstructured":"Jauhri M, Gupta V, Shokeen Y, Minhas S, Bhalla S, Aggarwal S (2017) KDR mutation: a high-frequency rare mutation and its correlation with other somatic mutations in Indian colorectal cancer patients. Next Generat Sequenc & Applic 4(2):148","journal-title":"Next Generat Sequenc & Applic"},{"issue":"11","key":"12_CR8","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nm.1877","volume":"14","author":"M Jinnin","year":"2008","unstructured":"Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR (2008) Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med 14(11):1236\u20131246","journal-title":"Nat Med"},{"key":"12_CR9","volume-title":"Capillary infantile hemangiomas","author":"K Koka","year":"2023","unstructured":"Koka K, Patel BC (2023) Capillary infantile hemangiomas. StatPearls Publishing, Treasure Island"},{"issue":"10089","key":"12_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0140-6736(16)00645-0","volume":"390","author":"C L\u00e9aut\u00e9-Labr\u00e8ze","year":"2017","unstructured":"L\u00e9aut\u00e9-Labr\u00e8ze C, Harper JI, Hoeger PH (2017) Infantile haemangioma. Lancet 390(10089):85\u201394","journal-title":"Lancet"},{"issue":"4","key":"12_CR11","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3390\/ijms19041192","volume":"19","author":"P Mabeta","year":"2018","unstructured":"Mabeta P (2018) Oncosuppressors and oncogenes: role in haemangioma genesis and potential for therapeutic targeting. Int J Mol Sci 19(4):1192","journal-title":"Int J Mol Sci"},{"issue":"4","key":"12_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.clindermatol.2022.02.006","volume":"40","author":"P Mahajan","year":"2022","unstructured":"Mahajan P, Bergstrom KL, Phung TL, Metry DW (2022) The genetics of vascular birthmarks. Clin Dermatol 40(4):313\u2013321","journal-title":"Clin Dermatol"},{"issue":"6","key":"12_CR13","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.jaad.2021.08.019","volume":"85","author":"AI Rodr\u00edguez Bandera","year":"2021","unstructured":"Rodr\u00edguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF (2021) Infantile hemangioma. Part 1: epidemiology, pathogenesis, clinical presentation and assessment. J Am Acad Dermatol 85(6):1379\u20131392","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"12_CR14","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1158\/1078-0432.CCR-15-1811","volume":"22","author":"IP Silva","year":"2016","unstructured":"Silva IP, Salhi A, Giles KM, Vogelsang M, Han SW, Ismaili N, Lui KP, Robinson EM, Wilson MA, Shapiro RL, Pavlick A, Zhong J, Kirchhoff T, Osman I (2016) Identification of a novel pathogenic germline KDR variant in melanoma. Clin Cancer Res 22(10):2377\u20132385","journal-title":"Clin Cancer Res"},{"issue":"11","key":"12_CR15","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/bdr2.1023","volume":"109","author":"CJF Smith","year":"2017","unstructured":"Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD (2017) Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res 109(11):809\u2013815","journal-title":"Birth Defects Res"},{"issue":"9","key":"12_CR16","doi-asserted-by":"publisher","first-page":"13030\/qt5jt8q9k","DOI":"10.5070\/D3249041401","volume":"24","author":"YS Soliman","year":"2018","unstructured":"Soliman YS, Khachemoune A (2018) Infantile hemangiomas: our current understanding and treatment options. Dermatol Online J 24(9):13030\/qt5jt8q9km","journal-title":"Dermatol Online J"},{"issue":"12","key":"12_CR17","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1093\/annonc\/mdw426","volume":"27","author":"I Tinhofer","year":"2016","unstructured":"Tinhofer I, Stenzinger A, Eder T, Konschak R, Niehr F, Endris V, Distel L, Hautmann MG, Mandic R, Stromberger C, Weichert W, Budach V (2016) Targeted next-generation sequencing identifies molecular subgroups in squamous cell carcinoma of the head and neck with distinct outcome after concurrent chemoradiation. Ann Oncol 27(12):2262\u20132268","journal-title":"Ann Oncol"},{"issue":"8","key":"12_CR18","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.jacc.2007.04.074","volume":"50","author":"Y Wang","year":"2007","unstructured":"Wang Y, Zheng Y, Zhang W, Yu H, Lou K, Zhang Y, Qin Q, Zhao B, Yang Y, Hui R (2007) Polymorphisms of KDR gene are associated with coronary heart disease. J Am Coll Cardiol 50(8):760\u2013767","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"12_CR19","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/clc.23233","volume":"42","author":"L Wang","year":"2019","unstructured":"Wang L, Ge H, Peng L, Wang B (2019) A meta-analysis of the relationship between VEGFR2 polymorphisms and atherosclerotic cardiovascular diseases. Clin Cardiol 42(10):860\u2013865","journal-title":"Clin Cardiol"},{"issue":"6","key":"12_CR20","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/S0002-9440(10)63077-5","volume":"159","author":"Y Yu","year":"2001","unstructured":"Yu Y, Varughese J, Brown LF, Mulliken JB, Bischoff J (2001) Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 159(6):2271\u20132280","journal-title":"Am J Pathol"},{"issue":"6","key":"12_CR21","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1634\/stemcells.2005-0298","volume":"24","author":"Y Yu","year":"2006","unstructured":"Yu Y, Fuhr J, Boye E, Gyorffy S, Soker S, Atala A, Mulliken JB, Bischoff J (2006) Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells 24(6):1605\u20131612","journal-title":"Stem Cells"},{"issue":"6","key":"12_CR22","doi-asserted-by":"publisher","first-page":"715","DOI":"10.21873\/cgp.20226","volume":"17","author":"N Zaman","year":"2020","unstructured":"Zaman N, Dass SS, Du Parcq P, Macmahon S, Gallagher L, Thompson L, Khorashad JS, Limback-Stanic C (2020) The KDR (VEGFR-2) genetic polymorphism Q472H and c-KIT polymorphism M541L are associated with more aggressive behaviour in astrocytic gliomas. Cancer Genom Proteom 17(6):715\u2013727","journal-title":"Cancer Genom Proteom"},{"issue":"4","key":"12_CR23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1080\/15384047.2018.1537575","volume":"20","author":"X Zhu","year":"2019","unstructured":"Zhu X, Wang Y, Xue W, Wang R, Wang L, Zhu M, Zheng L (2019) The VEGFR-2 protein and the VEGFR-2 rs1870377 a>T genetic polymorphism are prognostic factors for gastric cancer. Cancer Biol Ther 20(4):497\u2013504","journal-title":"Cancer Biol Ther"}],"container-title":["Advances in Experimental Medicine and Biology","GeNeDIS 2024"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-03398-7_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:43:05Z","timestamp":1784274185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-03398-7_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"ISBN":["9783032033970","9783032033987"],"references-count":23,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-03398-7_12","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]},"assertion":[{"value":"23 November 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"GeNeDIS","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International\u00a0Genomics, Neuroscience, Therapeutics and Data\u00a0Innovation\u00a0Summit","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Athens","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Greece","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2024","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"17 October 2024","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"20 October 2024","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"genedis-12024","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/easychair.org\/cfp\/GeNeDis2024","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}