{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:25:31Z","timestamp":1775003131583,"version":"3.50.1"},"publisher-location":"Cham","reference-count":66,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032041524","type":"print"},{"value":"9783032041531","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-04153-1_4","type":"book-chapter","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:31:30Z","timestamp":1774999890000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unique Expression and Glycosylation of Amyloid Precursor Protein in Alzheimer\u2019s Disease"],"prefix":"10.1007","author":[{"given":"Yuriko","family":"Tachida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Kitazume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/glycob\/cwp152","volume":"20","author":"K Akasaka-Manya","year":"2010","unstructured":"Akasaka-Manya K, Manya H, Sakurai Y, Wojczyk BS, Kozutsumi Y, Saito Y, Taniguchi N, Murayama S, Spitalnik SL, Endo T (2010) Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer\u2019s disease. Glycobiology 20:99\u2013106. https:\/\/doi.org\/10.1093\/glycob\/cwp152","journal-title":"Glycobiology"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/jb\/mvw056","volume":"161","author":"K Akasaka-Manya","year":"2017","unstructured":"Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Tachida Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga SI, Murayama S, Hashimoto Y, Manya H, Endo T (2017) Excess APP O-glycosylation by GalNAc-T6 decreases Abeta production. J Biochem 161:99\u2013111. https:\/\/doi.org\/10.1093\/jb\/mvw056","journal-title":"J Biochem"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1001\/jamaneurol.2015.4078","volume":"73","author":"E Auriel","year":"2016","unstructured":"Auriel E, Charidimou A, Gurol ME, Ni J, Van Etten ES, Martinez-Ramirez S, Boulouis G, Piazza F, Difrancesco JC, Frosch MP, Pontes-Neto OV, Shoamanesh A, Reijmer Y, Vashkevich A, Ayres AM, Schwab KM, Viswanathan A, Greenberg SM (2016) Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation. JAMA Neurol 73:197\u2013202. https:\/\/doi.org\/10.1001\/jamaneurol.2015.4078","journal-title":"JAMA Neurol"},{"key":"4_CR1002","doi-asserted-by":"publisher","unstructured":"Boix CP, Lopez-Font I, Cuchillo-Iba\u00f1ez I, S\u00e1ez-Valero J (2020) Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer's disease. Alzheimers Res Ther 12:96. https:\/\/doi.org\/10.1186\/s13195-020-00664-9","DOI":"10.1186\/s13195-020-00664-9"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"15977","DOI":"10.1016\/S0021-9258(18)55493-4","volume":"265","author":"AI Bush","year":"1990","unstructured":"Bush AI, Martins RN, Rumble B, Moir R, Fuller S, Milward E, Currie J, Ames D, Weidemann A, Fischer P et al (1990) The amyloid precursor protein of Alzheimer\u2019s disease is released by human platelets. J Biol Chem 265:15977\u201315983. https:\/\/doi.org\/10.1016\/S0021-9258(18)55493-4","journal-title":"J Biol Chem"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"27765","DOI":"10.1074\/jbc.273.43.27765","volume":"273","author":"JD Buxbaum","year":"1998","unstructured":"Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA (1998) Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273:27765\u201327767. https:\/\/doi.org\/10.1074\/jbc.273.43.27765","journal-title":"J Biol Chem"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jnnp-2011-301308","volume":"83","author":"A Charidimou","year":"2012","unstructured":"Charidimou A, Gang Q, Werring DJ (2012) Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry 83:124\u2013137. https:\/\/doi.org\/10.1136\/jnnp-2011-301308","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100081","volume":"20","author":"Z Chen","year":"2021","unstructured":"Chen Z, Yu Q, Yu Q, Johnson J, Shipman R, Zhong X, Huang J, Asthana S, Carlsson C, Okonkwo O, Li L (2021) In-depth site-specific analysis of N-glycoproteome in human cerebrospinal fluid and glycosylation landscape changes in Alzheimer\u2019s disease. Mol Cell Proteomics 20:100081. https:\/\/doi.org\/10.1016\/j.mcpro.2021.100081","journal-title":"Mol Cell Proteomics"},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/19083","volume":"398","author":"B De Strooper","year":"1999","unstructured":"De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518\u2013522. https:\/\/doi.org\/10.1038\/19083","journal-title":"Nature"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"12849","DOI":"10.1073\/pnas.0701267104","volume":"104","author":"M Fiala","year":"2007","unstructured":"Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J (2007) Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer\u2019s disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci USA 104:12849\u201312854. https:\/\/doi.org\/10.1073\/pnas.0701267104","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/(sici)1097-4547(19971001)50:1<50::Aid-jnr6>3.0.Co;2-k","volume":"50","author":"FJ Garcia-Ladona","year":"1997","unstructured":"Garcia-Ladona FJ, Huss Y, Frey P, Ghandour MS (1997) Oligodendrocytes express different isoforms of ?-amyloid precursor protein in chemically defined cell culture conditions: in situ hybridization and immunocytochemical detection. J Neurosci Res 50:50\u201361. https:\/\/doi.org\/10.1002\/(sici)1097-4547(19971001)50:1<50::Aid-jnr6>3.0.Co;2-k","journal-title":"J Neurosci Res"},{"key":"4_CR1004","doi-asserted-by":"publisher","unstructured":"Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT (2015) A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. Proc Natl Acad Sci U S A 112:14623\u201314628. https:\/\/doi.org\/10.1073\/pnas.1511175112","DOI":"10.1073\/pnas.1511175112"},{"key":"4_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","volume":"16","author":"SM Greenberg","year":"2020","unstructured":"Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, Van Veluw SJ (2020) Cerebral amyloid angiopathy and Alzheimer disease \u2013 one peptide, two pathways. Nat Rev Neurol 16:30\u201342. https:\/\/doi.org\/10.1038\/s41582-019-0281-2","journal-title":"Nat Rev Neurol"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","volume":"22","author":"A Grubman","year":"2019","unstructured":"Grubman A, Chew G, Ouyang JF, Sun G, Choo XY, Mclean C, Simmons RK, Buckberry S, Vargas-Landin DB, Poppe D, Pflueger J, Lister R, Rackham OJL, Petretto E, Polo JM (2019) A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation. Nat Neurosci 22:2087\u20132097. https:\/\/doi.org\/10.1038\/s41593-019-0539-4","journal-title":"Nat Neurosci"},{"key":"4_CR13","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006270","volume":"2","author":"C Haass","year":"2012","unstructured":"Haass C, Kaether C, Thinakaran G, Sisodia S (2012) Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2:a006270. https:\/\/doi.org\/10.1101\/cshperspect.a006270","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","volume":"21","author":"E Karran","year":"2022","unstructured":"Karran E, De Strooper B (2022) The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nat Rev Drug Discov 21:306\u2013318. https:\/\/doi.org\/10.1038\/s41573-022-00391-w","journal-title":"Nat Rev Drug Discov"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"13554","DOI":"10.1073\/pnas.241509198","volume":"98","author":"S Kitazume","year":"2001","unstructured":"Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y (2001) Alzheimer\u2019s beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci USA 98:13554\u201313559. https:\/\/doi.org\/10.1073\/pnas.241509198","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10719-006-6671-x","volume":"23","author":"S Kitazume","year":"2006","unstructured":"Kitazume S, Tachida Y, Oka R, Nakagawa K, Takashima S, Lee YC, Hashimoto Y (2006) Screening a series of sialyltransferases for possible BACE1 substrates. Glycoconj J 23:437\u2013441. https:\/\/doi.org\/10.1007\/s10719-006-6671-x","journal-title":"Glycoconj J"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"40097","DOI":"10.1074\/jbc.M110.144626","volume":"285","author":"S Kitazume","year":"2010","unstructured":"Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N (2010) Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. J Biol Chem 285:40097\u201340103. https:\/\/doi.org\/10.1074\/jbc.M110.144626","journal-title":"J Biol Chem"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"40817","DOI":"10.1074\/jbc.M112.398578","volume":"287","author":"S Kitazume","year":"2012","unstructured":"Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N (2012) Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome. J Biol Chem 287:40817\u201340825. https:\/\/doi.org\/10.1074\/jbc.M112.398578","journal-title":"J Biol Chem"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/prca.201200135","volume":"7","author":"S Kitazume","year":"2013","unstructured":"Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Takeishi Y, Yamamoto N, Taniguchi N (2013) Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome. Proteomics Clin Appl 7:657\u2013663. https:\/\/doi.org\/10.1002\/prca.201200135","journal-title":"Proteomics Clin Appl"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.15252\/emmm.201404438","volume":"7","author":"Y Kizuka","year":"2015","unstructured":"Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N (2015) An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer\u2019s disease. EMBO Mol Med 7:175\u2013189. https:\/\/doi.org\/10.15252\/emmm.201404438","journal-title":"EMBO Mol Med"},{"key":"4_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/BJ20150607","volume":"473","author":"Y Kizuka","year":"2016","unstructured":"Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N (2016) Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J 473:21\u201330. https:\/\/doi.org\/10.1042\/BJ20150607","journal-title":"Biochem J"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1016\/j.bbagen.2017.04.012","volume":"1861","author":"Y Kizuka","year":"2017","unstructured":"Kizuka Y, Kitazume S, Taniguchi N (2017) N-glycan and Alzheimer\u2019s disease. Biochim Biophys Acta Gen Subj 1861:2447\u20132454. https:\/\/doi.org\/10.1016\/j.bbagen.2017.04.012","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1038\/emboj.2012.173","volume":"31","author":"PH Kuhn","year":"2012","unstructured":"Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Rossner S, Brase S, Lichtenthaler SF (2012) Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J 31:3157\u20133168. https:\/\/doi.org\/10.1038\/emboj.2012.173","journal-title":"EMBO J"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1073\/pnas.96.7.3922","volume":"96","author":"S Lammich","year":"1999","unstructured":"Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96:3922\u20133927. https:\/\/doi.org\/10.1073\/pnas.96.7.3922","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR1001","doi-asserted-by":"publisher","unstructured":"Lin T, van Husen LS, Yu Y, Tjernberg LO, Schedin-Weiss S (2022) Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein. Glycobiology 32:506\u2013516. https:\/\/doi.org\/10.1093\/glycob\/cwac009","DOI":"10.1093\/glycob\/cwac009"},{"key":"4_CR1003","doi-asserted-by":"publisher","unstructured":"Liu F, Xu K, Xu Z, de Las Rivas M, Wang C, Li X, Lu J, Zhou Y, Delso I, Merino P, Hurtado-Guerrero R, Zhang Y, Wu F (2017) The small molecule luteolin inhibits N-acetyl-\u03b1-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. J Biol Chem 292:21304\u201321319. https:\/\/doi.org\/10.1074\/jbc.M117.809186","DOI":"10.1074\/jbc.M117.809186"},{"key":"4_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long JM, Holtzman DM (2019) Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179:312\u2013339. https:\/\/doi.org\/10.1016\/j.cell.2019.09.001","journal-title":"Cell"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","volume":"570","author":"H Mathys","year":"2019","unstructured":"Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH (2019) Single-cell transcriptomic analysis of Alzheimer\u2019s disease. Nature 570:332\u2013337. https:\/\/doi.org\/10.1038\/s41586-019-1195-2","journal-title":"Nature"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"13194","DOI":"10.1074\/jbc.RA120.012904","volume":"295","author":"S Miura","year":"2020","unstructured":"Miura S, Yoshihisa A, Misaka T, Yamaki T, Kojima T, Toyokawa M, Ogawa K, Shimura H, Yamamoto N, Kasahara K, Takeishi Y, Kitazume S (2020) Amyloid precursor protein 770 is specifically expressed and released from platelets. J Biol Chem 295:13194\u201313201. https:\/\/doi.org\/10.1074\/jbc.RA120.012904","journal-title":"J Biol Chem"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bbrc.2018.05.126","volume":"502","author":"M Moniruzzaman","year":"2018","unstructured":"Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S (2018) Glycosylation status of nicastrin influences catalytic activity and substrate preference of gamma-secretase. Biochem Biophys Res Commun 502:98\u2013103. https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.126","journal-title":"Biochem Biophys Res Commun"},{"key":"4_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41593-022-01222-2","volume":"26","author":"MH Murdock","year":"2023","unstructured":"Murdock MH, Tsai LH (2023) Insights into Alzheimer\u2019s disease from single-cell genomic approaches. Nat Neurosci 26:181\u2013195. https:\/\/doi.org\/10.1038\/s41593-022-01222-2","journal-title":"Nat Neurosci"},{"key":"4_CR30","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/j.1471-4159.2005.03595.x","volume":"96","author":"K Nakagawa","year":"2006","unstructured":"Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T, Hashimoto Y (2006) Sialylation enhances the secretion of neurotoxic amyloid-beta peptides. J Neurochem 96:924\u2013933. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03595.x","journal-title":"J Neurochem"},{"key":"4_CR31","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nm840","volume":"9","author":"JA Nicoll","year":"2003","unstructured":"Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9:448\u2013452. https:\/\/doi.org\/10.1038\/nm840","journal-title":"Nat Med"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jprot.2015.10.006","volume":"131","author":"A Palmigiano","year":"2016","unstructured":"Palmigiano A, Barone R, Sturiale L, Sanfilippo C, Bua RO, Romeo DA, Messina A, Capuana ML, Maci T, Le Pira F, Zappia M, Garozzo D (2016) CSF N-glycoproteomics for early diagnosis in Alzheimer\u2019s disease. J Proteomics 131:29\u201337. https:\/\/doi.org\/10.1016\/j.jprot.2015.10.006","journal-title":"J Proteomics"},{"key":"4_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","volume":"15","author":"F Panza","year":"2019","unstructured":"Panza F, Lozupone M, Logroscino G, Imbimbo BP (2019) A critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol 15:73\u201388. https:\/\/doi.org\/10.1038\/s41582-018-0116-6","journal-title":"Nat Rev Neurol"},{"key":"4_CR34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.tig.2007.01.008","volume":"23","author":"AL Parks","year":"2007","unstructured":"Parks AL, Curtis D (2007) Presenilin diversifies its portfolio. Trends Genet 23:140\u2013150. https:\/\/doi.org\/10.1016\/j.tig.2007.01.008","journal-title":"Trends Genet"},{"key":"4_CR35","doi-asserted-by":"publisher","first-page":"9728","DOI":"10.1021\/bi9906827","volume":"38","author":"S Parvathy","year":"1999","unstructured":"Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM (1999) Cleavage of Alzheimer\u2019s amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells. Biochemistry 38:9728\u20139734. https:\/\/doi.org\/10.1021\/bi9906827","journal-title":"Biochemistry"},{"key":"4_CR36","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1021\/pr800758g","volume":"8","author":"I Perdivara","year":"2009","unstructured":"Perdivara I, Petrovich R, Allinquant B, Deterding LJ, Tomer KB, Przybylski M (2009) Elucidation of O-glycosylation structures of the beta-amyloid precursor protein by liquid chromatography-mass spectrometry using electron transfer dissociation and collision induced dissociation. J Proteome Res 8:631\u2013642. https:\/\/doi.org\/10.1021\/pr800758g","journal-title":"J Proteome Res"},{"key":"4_CR37","doi-asserted-by":"publisher","first-page":"18851","DOI":"10.1074\/jbc.274.27.18851","volume":"274","author":"RG Perez","year":"1999","unstructured":"Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH (1999) Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem 274:18851\u201318856. https:\/\/doi.org\/10.1074\/jbc.274.27.18851","journal-title":"J Biol Chem"},{"key":"4_CR38","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1126\/science.1078259","volume":"298","author":"M Pfeifer","year":"2002","unstructured":"Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews PM, Jucker M (2002) Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 298:1379. https:\/\/doi.org\/10.1126\/science.1078259","journal-title":"Science"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/331525a0","volume":"331","author":"P Ponte","year":"1988","unstructured":"Ponte P, Gonzalez-Dewhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331:525\u2013527. https:\/\/doi.org\/10.1038\/331525a0","journal-title":"Nature"},{"key":"4_CR40","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0169-328x(97)00045-4","volume":"47","author":"HA Rohan De Silva","year":"1997","unstructured":"Rohan De Silva HA, Jen A, Wickenden C, Jen LS, Wilkinson SL, Patel AJ (1997) Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes. Brain Res Mol Brain Res 47:147\u2013156. https:\/\/doi.org\/10.1016\/s0169-328x(97)00045-4","journal-title":"Brain Res Mol Brain Res"},{"key":"4_CR41","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.15252\/embj.201797397","volume":"36","author":"H Sasaguri","year":"2017","unstructured":"Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC (2017) APP mouse models for Alzheimer\u2019s disease preclinical studies. EMBO J 36:2473\u20132487. https:\/\/doi.org\/10.15252\/embj.201797397","journal-title":"EMBO J"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/febs.12590","volume":"281","author":"S Schedin-Weiss","year":"2014","unstructured":"Schedin-Weiss S, Winblad B, Tjernberg LO (2014) The role of protein glycosylation in Alzheimer disease. FEBS J 281:46\u201362. https:\/\/doi.org\/10.1111\/febs.12590","journal-title":"FEBS J"},{"key":"4_CR43","doi-asserted-by":"publisher","first-page":"9893","DOI":"10.1073\/pnas.1203563109","volume":"109","author":"KT Schjoldager","year":"2012","unstructured":"Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H (2012) Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells. Proc Natl Acad Sci USA 109:9893\u20139898. https:\/\/doi.org\/10.1073\/pnas.1203563109","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR44","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41580-020-00294-x","volume":"21","author":"KT Schjoldager","year":"2020","unstructured":"Schjoldager KT, Narimatsu Y, Joshi HJ, Clausen H (2020) Global view of human protein glycosylation pathways and functions. Nat Rev Mol Cell Biol 21:729\u2013749. https:\/\/doi.org\/10.1038\/s41580-020-00294-x","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4_CR45","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"DJ Selkoe","year":"2016","unstructured":"Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol Med 8:595\u2013608. https:\/\/doi.org\/10.15252\/emmm.201606210","journal-title":"EMBO Mol Med"},{"key":"4_CR46","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/990114","volume":"402","author":"S Sinha","year":"1999","unstructured":"Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, John V et al (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537\u2013540. https:\/\/doi.org\/10.1038\/990114","journal-title":"Nature"},{"key":"4_CR47","doi-asserted-by":"publisher","first-page":"8220","DOI":"10.1038\/s41467-023-43933-5","volume":"14","author":"E Solopova","year":"2023","unstructured":"Solopova E, Romero-Fernandez W, Harmsen H, Ventura-Antunes L, Wang E, Shostak A, Maldonado J, Donahue MJ, Schultz D, Coyne TM, Charidimou A, Schrag M (2023) Fatal iatrogenic cerebral beta-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer\u2019s disease. Nat Commun 14:8220. https:\/\/doi.org\/10.1038\/s41467-023-43933-5","journal-title":"Nat Commun"},{"key":"4_CR48","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/emboj.2013.79","volume":"32","author":"C Steentoft","year":"2013","unstructured":"Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H (2013) Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. EMBO J 32:1478\u20131488. https:\/\/doi.org\/10.1038\/emboj.2013.79","journal-title":"EMBO J"},{"key":"4_CR49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41467-018-07971-8","volume":"10","author":"J Sun","year":"2019","unstructured":"Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, Mclean PJ, Sproul AA, Saha K, Roy S (2019) CRISPR\/Cas9 editing of APP C-terminus attenuates \u03b2-cleavage and promotes \u03b1-cleavage. Nat Commun 10:53. https:\/\/doi.org\/10.1038\/s41467-018-07971-8","journal-title":"Nat Commun"},{"key":"4_CR1000","doi-asserted-by":"publisher","unstructured":"Suttapitugsakul S, Stavenhagen K, Donskaya S, Bennett DA, Mealer RG, Seyfried NT, Cummings RD (2022) Glycoproteomics landscape of asymptomatic and symptomatic human alzheimer\u2019s disease brain. Mol Cell Proteomics 21:100433. https:\/\/doi.org\/10.1016\/j.mcpro.2022.100433","DOI":"10.1016\/j.mcpro.2022.100433"},{"key":"4_CR50","doi-asserted-by":"publisher","unstructured":"Tachida Y, Miura S, Muto Y, Takuwa H, Sahara N, Shindo A, Matsuba Y, Saito T, Taniguchi N, Kawaguchi Y, Tomimoto H, Saido T, Kitazume S (2022) Endothelial expression of human amyloid precursor protein leads to amyloid beta in the blood and induces cerebral amyloid angiopathy in knock-in mice. J Biol Chem 101880. https:\/\/doi.org\/10.1016\/j.jbc.2022.101880","DOI":"10.1016\/j.jbc.2022.101880"},{"key":"4_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104905","volume":"299","author":"Y Tachida","year":"2023","unstructured":"Tachida Y, Iijima J, Takahashi K, Suzuki H, Kizuka Y, Yamaguchi Y, Tanaka K, Nakano M, Takakura D, Kawasaki N, Saito Y, Manya H, Endo T, Kitazume S (2023) O-GalNAc glycosylation determines intracellular trafficking of APP and Abeta production. J Biol Chem 299:104905. https:\/\/doi.org\/10.1016\/j.jbc.2023.104905","journal-title":"J Biol Chem"},{"key":"4_CR52","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/331528a0","volume":"331","author":"RE Tanzi","year":"1988","unstructured":"Tanzi RE, Mcclatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer\u2019s disease. Nature 331:528\u2013530. https:\/\/doi.org\/10.1038\/331528a0","journal-title":"Nature"},{"key":"4_CR53","doi-asserted-by":"publisher","first-page":"20664","DOI":"10.1074\/jbc.M109.055608","volume":"285","author":"S Ullrich","year":"2010","unstructured":"Ullrich S, Munch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (2010) The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J Biol Chem 285:20664\u201320674. https:\/\/doi.org\/10.1074\/jbc.M109.055608","journal-title":"J Biol Chem"},{"key":"4_CR54","doi-asserted-by":"publisher","DOI":"10.1101\/9781621824213","volume-title":"Essentials of glycobiology","author":"A Varki","year":"2022","unstructured":"Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard J et al (2022) Essentials of glycobiology, 4th edn. Cold Spring Harbour Laboratory Press. https:\/\/doi.org\/10.1101\/9781621824213","edition":"4"},{"key":"4_CR55","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE [see comments]. Science 286:735\u2013741. https:\/\/doi.org\/10.1126\/science.286.5440.735","journal-title":"Science"},{"key":"4_CR56","doi-asserted-by":"publisher","first-page":"9513","DOI":"10.1073\/pnas.90.20.9513","volume":"90","author":"AM Wertkin","year":"1993","unstructured":"Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM (1993) Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci USA 90:9513\u20139517. https:\/\/doi.org\/10.1073\/pnas.90.20.9513","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR57","doi-asserted-by":"publisher","first-page":"23824","DOI":"10.1074\/jbc.M601542200","volume":"281","author":"C Wild-Bode","year":"2006","unstructured":"Wild-Bode C, Fellerer K, Kugler J, Haass C, Capell A (2006) A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration. J Biol Chem 281:23824\u201323829. https:\/\/doi.org\/10.1074\/jbc.M601542200","journal-title":"J Biol Chem"},{"key":"4_CR58","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/19077","volume":"398","author":"MS Wolfe","year":"1999","unstructured":"Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398:513\u2013517. https:\/\/doi.org\/10.1038\/19077","journal-title":"Nature"},{"key":"4_CR59","doi-asserted-by":"publisher","first-page":"18135","DOI":"10.1073\/pnas.0507798102","volume":"102","author":"F Xu","year":"2005","unstructured":"Xu F, Davis J, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE (2005) Protease nexin-2\/amyloid beta-protein precursor limits cerebral thrombosis. Proc Natl Acad Sci USA 102:18135\u201318140. https:\/\/doi.org\/10.1073\/pnas.0507798102","journal-title":"Proc Natl Acad Sci USA"},{"key":"4_CR60","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/990107","volume":"402","author":"R Yan","year":"1999","unstructured":"Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME (1999) Membrane-anchored aspartyl protease with Alzheimer\u2019s disease beta- secretase activity. Nature 402:533\u2013537. https:\/\/doi.org\/10.1038\/990107","journal-title":"Nature"},{"key":"4_CR1010","doi-asserted-by":"publisher","unstructured":"Zhang Q, Ma C, Chin LS, Li L (2020) Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer\u2019s disease. Sci Adv 6:eabc5802. https:\/\/doi.org\/10.1126\/sciadv.abc5802","DOI":"10.1126\/sciadv.abc5802"}],"container-title":["Advances in Experimental Medicine and Biology","The Molecular Immunology of Complex Carbohydrates - 4"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-04153-1_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:31:31Z","timestamp":1774999891000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-04153-1_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032041524","9783032041531"],"references-count":66,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-04153-1_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"1 April 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}