{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:41:49Z","timestamp":1769672509062,"version":"3.49.0"},"publisher-location":"Cham","reference-count":66,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032075222","type":"print"},{"value":"9783032075239","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-07523-9_1","type":"book-chapter","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:06:13Z","timestamp":1769623573000},"page":"3-18","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Architectural Forces in Ion Selectivity"],"prefix":"10.1007","author":[{"given":"Beno\u00eet","family":"Roux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"10019","DOI":"10.1021\/j100203a079","volume":"96","author":"JJ \u00c5qvist","year":"1992","unstructured":"\u00c5qvist, JJ, Alvarez O, Eisenman G (1992) Ion-selective properties of a small ionophore in methanol studied by free energy perturbation simulations. J Phys Chem 96:10019\u201310025","journal-title":"J Phys Chem"},{"issue":"11","key":"1_CR2","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1085\/jgp.50.11.2527","volume":"50","author":"TE Andreoli","year":"1967","unstructured":"Andreoli TE, Tieffenberg M, Tosteson DC (1967) The effect of valinomycin on the ionic permeability of thin lipid membranes. J Gen Physiol 50(11):2527\u20132545","journal-title":"J Gen Physiol"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/242459a0","volume":"242","author":"C Armstrong","year":"1973","unstructured":"Armstrong C, Bezanilla F (1973) Currents related to movement of the gating particles of the sodium channels. Nature 242:459\u2013461","journal-title":"Nature"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1021\/ja0382967","volume":"126","author":"D Asthagiri","year":"2004","unstructured":"Asthagiri D, Pratt LR, Paulaitis ME, Rempe SB (2004) Hydration structure and free energy of biomolecularly specific aqueous dications, including zn2+ and first transition row metals. J Am Chem Soc 126:1285\u20131289","journal-title":"J Am Chem Soc"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"24701","DOI":"10.1063\/1.2205853","volume":"125","author":"D Asthagiri","year":"2006","unstructured":"Asthagiri D, Pratt L, Paulaitis M (2006) Role of fluctuations in a snug-fit mechanism of KcsA channel selectivity. J Chem Phys 125:24701","journal-title":"J Chem Phys"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"4711","DOI":"10.1021\/ja0367290","volume":"126","author":"F Ban","year":"2004","unstructured":"Ban F, Kusalik P, Weaver DF (2004) Density functional theory investigations on the chemical basis of the selectivity filter in the K+ channel protein. J Am Chem Soc 126:4711\u20134716","journal-title":"J Am Chem Soc"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0014-5793(03)01151-7","volume":"555","author":"O Beckstein","year":"2003","unstructured":"Beckstein O, Biggin P, Bond P, Bright JN, Domene C, Grottesi A, Holyoake J, Sansom MS (2003) Ion channel gating: insights via molecular simulations. FEBS Lett 555:85\u201390","journal-title":"FEBS Lett"},{"key":"1_CR8","doi-asserted-by":"crossref","unstructured":"Armstrong CM (2003) Voltage-gated K channels. Sci STKE 2003:re10","DOI":"10.1126\/scisignal.1882003re10"},{"key":"1_CR9","volume-title":"Biochemistry","author":"JM Berg","year":"2002","unstructured":"Berg JM, Tymoczko JL, Stryer L (2002) Biochemistry, 5th edn. W.H. Freeman and Co., New York","edition":"5"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1016\/S0006-3495(00)76831-7","volume":"78","author":"S Bern\u00e8che","year":"2000","unstructured":"Bern\u00e8che S, Roux B (2000) Molecular dynamics of the KcsA K(+) channel in a bilayer membrane. Biophys J 78:2900\u20132917","journal-title":"Biophys J"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/35102067","volume":"414","author":"S Bern\u00e8che","year":"2001","unstructured":"Bern\u00e8che S, Roux B (2001) Energetics of ion conduction through the k+ channel. Nature 414:73\u201377","journal-title":"Nature"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"8644","DOI":"10.1073\/pnas.1431750100","volume":"100","author":"S Bern\u00e8che","year":"2003","unstructured":"Bern\u00e8che S, Roux B (2003) A microscopic view of ion conduction through the KcsA K+ channel. Proc Natl Acad Sci 100:8644\u20138648","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1085\/jgp.60.5.588","volume":"60","author":"F Bezanilla","year":"1972","unstructured":"Bezanilla F, Armstrong CM (1972) Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. J Gen Physiol 60:588\u2013608","journal-title":"J Gen Physiol"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1529\/biophysj.107.122796","volume":"94","author":"D Boda","year":"2008","unstructured":"Boda D, Nonner W, Henderson D, Eisenberg B, Gillespie D (2008) Volume exclusion in calcium selective channels. Biophys J 94:3486\u20133496","journal-title":"Biophys J"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"4165","DOI":"10.1021\/ct400296w","volume":"9","author":"L Bogdan","year":"2013","unstructured":"Bogdan L, Roux B, Noskov S (2013) Relative free energies for hydration of monovalent ions from QM and QM\/MM simulations. J Chem Theor Comp 9:4165\u20134175","journal-title":"J Chem Theor Comp"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"9260","DOI":"10.1073\/pnas.0700554104","volume":"104","author":"DL Bostick","year":"2007","unstructured":"Bostick DL, Brooks CL (2007) Selectivity in K$$^{+}$$ channels is due to topological control of the permeant ion\u2019s coordinated state. Proc Natl Acad Sci USA 104:9260\u20139265","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"4470","DOI":"10.1016\/j.bpj.2009.03.001","volume":"96","author":"DL Bostick","year":"2009","unstructured":"Bostick DL, Brooks CL (2009) Statistical determinants of selective ionic complexation: ions in solvent, transport proteins, and other \u201chosts\u201d. Biophys J 96:4470\u20134492","journal-title":"Biophys J"},{"key":"1_CR18","doi-asserted-by":"crossref","unstructured":"Brooks BR, Brooks III CL, Mackerell Jr AD, Nilsson L, Petrella RJ, Roux B, Won Y, Archontis G, Bartels C, Boresch S, Caflisch A, Caves L, Cui Q, Dinner AR, Feig M, Fischer S, Gao J, Hodoscek M, Im W, Kuczera K, Lazaridis T, Ma J, Ovchinnikov V, Paci E, Pastor RW, Post CB, Pu JZ, Schaefer M, Tidor B, Venable RM, Woodcock HL, Wu X, Yang W, York DM, Karplus M (2009) CHARMM: the biomolecular simulation program. J Comp Chem 30(10, Sp. Iss. SI):1545\u20131614","DOI":"10.1002\/jcc.21287"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"115103","DOI":"10.1063\/1.2842080","volume":"128","author":"YQ Deng","year":"2008","unstructured":"Deng YQ, Roux B (2008) Computation of binding free energy with molecular dynamics and grand canonical Monte Carlo simulations. J Chem Phys 128:115103","journal-title":"J Chem Phys"},{"issue":"1985","key":"1_CR20","first-page":"954","volume":"62","author":"B Dietrich","year":"1985","unstructured":"Dietrich B (1985) Coordination chemistry of alkali and alkaline-earth cations with macrocyclic ligands. B. Dietrich, J. Chem. Ed. 62 (1985) 954\u2013964.","journal-title":"Ed"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.280.5360.69","volume":"280","author":"D Doyle","year":"1998","unstructured":"Doyle D, Cabral J, Pfuetzner R, Kuo A, Gulbis J, Cohen S, Chait B, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69\u201377","journal-title":"Science"},{"issue":"supp 2","key":"1_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0006-3495(62)86959-8","volume":"2","author":"G Eisenman","year":"1962","unstructured":"Eisenman G (1962) Cation selective electrodes and their mode of operation. Biophys J 2(supp 2):259\u2013323","journal-title":"Biophys J"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1016\/S0006-3495(03)70011-3","volume":"84","author":"S Garofoli","year":"2003","unstructured":"Garofoli S, Jordan PC (2003) Modeling permeation energetics in the KcsA potassium channel. Biophys J 84:2814\u20132830","journal-title":"Biophys J"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1063\/1.475640","volume":"108","author":"G Gerardo Soto-Campos","year":"1998","unstructured":"Gerardo Soto-Campos G, Corti DS, Reiss H (1998) A small system grand ensemble method for the study of hard-particle systems. J Chem Phys 108:2563\u20132570","journal-title":"J Chem Phys"},{"issue":"23","key":"1_CR25","doi-asserted-by":"publisher","first-page":"6786","DOI":"10.1021\/ja00361a003","volume":"105","author":"G Gokel","year":"1983","unstructured":"Gokel G, Goli D, Mlinganti C, Echegoyen L (1983) Clarification of the hole-size cation-diameter relationship in crown ethers and a new method for determining calcium cation homogeneous binding constant. J Am Chem Soc 105(23):6786\u20136788","journal-title":"J Am Chem Soc"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1126\/science.1113666","volume":"310","author":"E Gouaux","year":"2005","unstructured":"Gouaux E, Mackinnon R (2005) Principles of selective ion transport in channels and pumps. Science 310:1461\u20131465","journal-title":"Science"},{"issue":"6","key":"1_CR27","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1021\/ct600180x","volume":"2","author":"E Harder","year":"2006","unstructured":"Harder E, Anisimov VM, Vorobyov IV, Lopes PEM, Noskov SY, MacKerell AD, Roux B (2006) Atomic level anisotropy in the electrostatic modeling of lone pairs for a polarizable force field based on the classical Drude oscillator. J Chem Theor Comp 2(6):1587\u20131597","journal-title":"J Chem Theor Comp"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/13415","volume":"5","author":"B Hille","year":"1999","unstructured":"Hille B, Armstrong CM, MacKinnon R (1999) Ion channels: from idea to reality. Nat Med 5:1105\u2013119","journal-title":"Nat Med"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1021\/jp951011v","volume":"100","author":"G Hummer","year":"1996","unstructured":"Hummer G, Pratt LR, Garcia AE (1996) Free energy of Ionic Hydration. J Phys Chem 100:1206\u20131215","journal-title":"J Phys Chem"},{"issue":"9","key":"1_CR30","doi-asserted-by":"publisher","first-page":"4165","DOI":"10.1021\/ct400296w","volume":"9","author":"B Lev","year":"2013","unstructured":"Lev B, Roux B, Noskov SY (2013) Relative Free Energies for Hydration of Monovalent Ions from QM and QM\/MM Simulations. J Chem Theo Comp 9(9):4165\u20134175","journal-title":"J Chem Theo Comp"},{"issue":"29","key":"1_CR31","doi-asserted-by":"publisher","first-page":"9401","DOI":"10.1021\/jp510560k","volume":"119","author":"H Li","year":"2015","unstructured":"Li H, Ngo VA, Da Silva MC, Callahan KM, Salahub DR, Roux B, Noskov SY (2015) Representation of Ion-Protein Interactions using the Drude Polarizable Force-Field. J Phys Chem B 119(29):9401\u20139416","journal-title":"J Phys Chem B"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1021\/jp973084f","volume":"102","author":"AJ MacKerell","year":"1998","unstructured":"MacKerell, AJ, Bashford D, Bellot M, Dunbrack R, Evanseck J, Field M, Fischer S, Gao J, Guo H, Ha, DJ-MS, Kuchnir L, Kuczera K, Lau F, Mattos C, Michnick S, Ngo T, Nguyen D, Prodhom B, Reiher III W, Roux B, Schlenkrich M, Smith J, Stote R, Straub J, Watanabe M, Wiorkiewicz-Kuczera J, Karplus M (1998) All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 102:3586\u20133616","journal-title":"J Phys Chem B"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1002\/anie.200400662","volume":"43","author":"R MacKinnon","year":"2004","unstructured":"MacKinnon R (2004) Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew Chem Int Ed Engl 43:4265\u20134277","journal-title":"Angew Chem Int Ed Engl"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"195102","DOI":"10.1063\/1.3132709","volume":"130","author":"S Merchant","year":"2009","unstructured":"Merchant S, Asthagiri D (2009) Thermodynamically dominant hydration structures of aqueous ions. J. Chem. Phys. 130, 195102","journal-title":"J. Chem. Phys."},{"issue":"25","key":"1_CR35","doi-asserted-by":"publisher","first-page":"6895","DOI":"10.1021\/ja00389a002","volume":"104","author":"G Michaux","year":"1982","unstructured":"Michaux G, Reisse J (1982) Solution thermodynamics studies: 6. Enthalpy-entropy compensation for the complexation reaction of some crown ethers with alkaline cations. Quantitative interpretation of the complexing properties of 18 Crown-6. J Am Chem Soc 104(25):6895\u20136899","journal-title":"J Am Chem Soc"},{"key":"1_CR36","doi-asserted-by":"crossref","unstructured":"Mueller P, Rudin DO (1967) Development of k$$^+$$-na$$^+$$ discrimination in experimental bimolecular lipid membranes by macrocyclic antibiotics. Biochem Biophys Res Commun 26(4):398\u2013404","DOI":"10.1016\/0006-291X(67)90559-1"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1085\/jgp.42.4.817","volume":"42","author":"L Mullins","year":"1959","unstructured":"Mullins L (1959) The penetration of some cations into muscle. J Gen Physiol 42:817\u2013829","journal-title":"J Gen Physiol"},{"issue":"3","key":"1_CR38","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1021\/acs.jctc.0c00968","volume":"17","author":"V Ngo","year":"2021","unstructured":"Ngo V, Li H, MacKerell AD, Allen TW, Roux B, Noskov S (2021) Polarization effects in water-mediated selective cation transport across a narrow transmembrane channel. J Chem Theory Comput 17(3):1726\u20131741","journal-title":"J Chem Theory Comput"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/S0006-3495(00)76446-0","volume":"79","author":"W Nonner","year":"2000","unstructured":"Nonner W, Catacuzzeno L, Eisenberg B (2000) Binding and selectivity in L-type calcium channels: a mean spherical approximation. Biophys J 79:1976\u20131992","journal-title":"Biophys J"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1085\/jgp.200609633","volume":"129","author":"S Noskov","year":"2007","unstructured":"Noskov S, Roux B (2007) Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. J Gen Physiol 129:135\u2013143","journal-title":"J Gen Physiol"},{"issue":"3","key":"1_CR41","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.jmb.2008.01.015","volume":"377","author":"SY Noskov","year":"2008","unstructured":"Noskov SY, Roux B (2008) Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol 377(3):804\u2013818","journal-title":"J Mol Biol"},{"key":"1_CR42","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/nature02943","volume":"431","author":"S Noskov","year":"2004","unstructured":"Noskov S, Berneche S, Roux B (2004) Control of ion selectivity in k(+) channels by dynamic and electrostatic properties of carbonyl ligands. Nature 431:830\u2013834","journal-title":"Nature"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.bpc.2006.05.033","volume":"124","author":"S Noskov","year":"2006","unstructured":"Noskov S, Berneche S, Roux B (2006) Ion selectivity in potassium channels. Biophys Chem 124:279\u2013291","journal-title":"Biophys Chem"},{"issue":"1","key":"1_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/anie.197200161","volume":"11","author":"C Pedersen","year":"1972","unstructured":"Pedersen C, Frensdor H (1972) Macrocyclic polyethers and their complexes. Angew Chem Intl Ed 11(1):16\u201325","journal-title":"Angew Chem Intl Ed"},{"key":"1_CR45","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1080\/002689798167485","volume":"94","author":"L Pratt","year":"1998","unstructured":"Pratt L, Laviolette R (1998) Quasi-chemical theories of associated liquids. Mol Phys 94:909\u2013915","journal-title":"Mol Phys"},{"key":"1_CR46","doi-asserted-by":"crossref","unstructured":"Rempe S, Pratt L (2001) The hydration number of Na+ in liquid water. Fluid Phase Equil. 183(Sp. Iss. SI):121\u2013132","DOI":"10.1016\/S0378-3812(01)00426-5"},{"issue":"5","key":"1_CR47","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1021\/ja9924750","volume":"122","author":"S Rempe","year":"2000","unstructured":"Rempe S, Pratt L, Hummer G, Kress J, Martin R, Redondo A (2000) The hydration number of Li+ in liquid water. J Am Chem Soc 122(5):966\u2013967","journal-title":"J Am Chem Soc"},{"issue":"8","key":"1_CR48","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1039\/B313756B","volume":"6","author":"S Rempe","year":"2004","unstructured":"Rempe S, Asthagiri D, Pratt L (2004) Inner shell definition and absolute hydration free energy of K+(aq) on the basis of quasi-chemical theory and ab initio molecular dynamics. Phys. Chem. Chem. Phys. 6(8):1966\u20131969","journal-title":"Phys. Chem. Chem. Phys."},{"key":"1_CR49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0009-2614(93)89319-D","volume":"212","author":"B Roux","year":"1993","unstructured":"Roux B (1993) Nonadditivity in cation-peptide interactions: a molecular dynamics and Ab initio study of Na$$^+$$ in the gramicidin channel. Chem. Phys. Lett. 212:231\u2013240","journal-title":"Chem. Phys. Lett."},{"key":"1_CR50","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1016\/j.bpj.2010.03.038","volume":"98","author":"B Roux","year":"2010","unstructured":"Roux B (2010) Exploring the ion selectivity properties of a large number of simplified binding site models. Biophys J 98:2877\u20132885","journal-title":"Biophys J"},{"issue":"23","key":"1_CR51","doi-asserted-by":"publisher","first-page":"6966","DOI":"10.1021\/jp3007365","volume":"116","author":"B Roux","year":"2012","unstructured":"Roux B (2012) Ion binding sites and their representations by reduced models. J Phys Chem B 116(23):6966\u20136979","journal-title":"J Phys Chem B"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"234101","DOI":"10.1063\/1.3436632","volume":"132","author":"B Roux","year":"2010","unstructured":"Roux B, Yu H (2010) Assessing the accuracy of approximate treatments of ion hydration based on primitive quasichemical theory. J Chem Phys 132:234101","journal-title":"J Chem Phys"},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1017\/S0033583504003968","volume":"37","author":"B Roux","year":"2004","unstructured":"Roux B, Allen TW, Bern\u00e8che S, Im W (2004) Theoretical and computational models of biological ion channels. Quat Rev Biophys 37:15\u2013103","journal-title":"Quat Rev Biophys"},{"key":"1_CR54","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1085\/jgp.201010577","volume":"137","author":"B Roux","year":"2011","unstructured":"Roux B, Berneche S, Egwolf B, Lev B, Noskov SY, Rowley CN, Yu H (2011) Ion selectivity in channels and transporters. J Gen Physiol 137:415\u2013426","journal-title":"J Gen Physiol"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1021\/ja800190c","volume":"130","author":"R Schneider","year":"2008","unstructured":"Schneider R, Ader C, Lange A, Giller K, Hornig S, Pongs O, Becker S, Baldus M (2008) Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers. J Am Chem Soc 130:7427\u20137435","journal-title":"J Am Chem Soc"},{"key":"1_CR56","unstructured":"Szabo G, Eisenman G, Laprade R, Ciani SM, Krasne S (1973) Experimentally observed effects of carriers on the electrical properties of bilayer membranes\u2013equilibrium domain. In: With a contribution on the molecular basis of ion selectivity. Membranes. pp 179\u2013328"},{"key":"1_CR57","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1529\/biophysj.107.108167","volume":"93","author":"M Thomas","year":"2007","unstructured":"Thomas M, Jayatilaka D, Corry B (2007) The predominant role of coordination number in potassium channel selectivity. Biophys J 93:2635\u20132643","journal-title":"Biophys J"},{"key":"1_CR58","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1126\/science.1133415","volume":"314","author":"F Valiyaveetil","year":"2006","unstructured":"Valiyaveetil F, Leonetti M, Muir T, Mackinnon R (2006) Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science 314:1004\u20131007","journal-title":"Science"},{"key":"1_CR59","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1529\/biophysj.107.107482","volume":"93","author":"S Varma","year":"2007","unstructured":"Varma S, Rempe S (2007) Tuning ion coordination architectures to enable selective partitioning. Biophys J 93:1093\u20131099","journal-title":"Biophys J"},{"key":"1_CR60","doi-asserted-by":"publisher","first-page":"15405","DOI":"10.1021\/ja803575y","volume":"130","author":"S Varma","year":"2008","unstructured":"Varma S, Rempe SB (2008) Structural transitions in ion coordination driven by changes in competition for ligand binding. J Am Chem Soc 130:15405\u201315419","journal-title":"J Am Chem Soc"},{"key":"1_CR61","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1073\/pnas.87.15.5648","volume":"87","author":"M Yamashita","year":"1990","unstructured":"Yamashita M, Wesson L, Eisenman G, Eisenberg D (1990) Where metal ions bind in proteins. Proc Natl Acad Sci USA 87:5648\u20135652","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR62","doi-asserted-by":"crossref","unstructured":"Yamashita A, Singh S, Kawate T, Jin Y, Gouaux E (2005) Crystal structure of a bacterial homologue of Na$$^+$$\/Cl$$^-$$-dependent neurotransmitter transporters. Nature 437:215\u2013223","DOI":"10.1038\/nature03978"},{"key":"1_CR63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nature00978","volume":"419","author":"G Yellen","year":"2002","unstructured":"Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35\u201342","journal-title":"Nature"},{"key":"1_CR64","doi-asserted-by":"publisher","first-page":"8725","DOI":"10.1021\/jp901233v","volume":"113","author":"H Yu","year":"2009","unstructured":"Yu H, Noskov SY, Roux B (2009) Hydration number, topological control, and ion selectivity. J Phys Chem B 113:8725\u20138730","journal-title":"J Phys Chem B"},{"issue":"47","key":"1_CR65","doi-asserted-by":"publisher","first-page":"20329","DOI":"10.1073\/pnas.1007150107","volume":"107","author":"H Yu","year":"2010","unstructured":"Yu H, Noskov SY, Roux B (2010) Two mechanisms of ion selectivity in protein binding sites. Proc Natl Acad Sci USA 107(47):20329\u201320334","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR66","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/35079500","volume":"411","author":"M Zhou","year":"2001","unstructured":"Zhou M, Morais-Cabral, JH, Mann S, MacKinnon R (2001) Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411:657\u2013661","journal-title":"Nature"}],"container-title":["Advances in Experimental Medicine and Biology","Decoding Ion Channels Structure and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-07523-9_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:02:14Z","timestamp":1769626934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-07523-9_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"ISBN":["9783032075222","9783032075239"],"references-count":66,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-07523-9_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"22 September 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}