{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:04:12Z","timestamp":1774451052143,"version":"3.50.1"},"publisher-location":"Cham","reference-count":32,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032076939","type":"print"},{"value":"9783032076946","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-07694-6_8","type":"book-chapter","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:05:08Z","timestamp":1759169108000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Finite-Element Electrophysiological Modeling of Human Uterine Smooth Muscle Using a Reduced Tong Model"],"prefix":"10.1007","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-713X","authenticated-orcid":false,"given":"Alberto","family":"Corrias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"2","key":"8_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/apha.12424","volume":"213","author":"C Rabotti","year":"2015","unstructured":"Rabotti, C., Mischi, M.: Propagation of electrical activity in uterine muscle during pregnancy: a review. Acta Physiol. 213(2), 406\u2013416 (2015)","journal-title":"Acta Physiol."},{"issue":"2","key":"8_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ajog.2015.06.040","volume":"213","author":"R Smith","year":"2015","unstructured":"Smith, R., Imtiaz, M., Banney, D., Paul, J.W., Young, R.C.: Why the heart is like an orchestra and the uterus is like a soccer crowd. Am. J. Obstet. Gynecol. 213(2), 181\u2013185 (2015)","journal-title":"Am. J. Obstet. Gynecol."},{"key":"8_CR3","doi-asserted-by":"crossref","unstructured":"van Gestel, I., IJland, M.M., Hoogland, H.J., Evers, J.L.H.: Endometrial wave-like activity in the non-pregnant uterus. Hum. Reprod. Update 9(2), 131\u2013138 (2003)","DOI":"10.1093\/humupd\/dmg011"},{"issue":"6","key":"8_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1515\/JPM.2007.116","volume":"35","author":"PCAM Bakker","year":"2007","unstructured":"Bakker, P.C.A.M., Van Rijsiwijk, S., van Geijn, H.P.: Uterine activity monitoring during labor. J. Perinat. Med. 35(6), 468\u2013477 (2007)","journal-title":"J. Perinat. Med."},{"key":"8_CR5","doi-asserted-by":"crossref","unstructured":"Wray, S., Prendergast, C.: The myometrium: from excitation to contractions and labour. In: Smooth Muscle Spontaneous Activity, vol. 1124, H. Hashitani and R. J. Lang, Eds., Singapore: Springer Singapore, pp. 233\u2013263 (2019)","DOI":"10.1007\/978-981-13-5895-1_10"},{"key":"8_CR6","doi-asserted-by":"crossref","unstructured":"Sanders, K.M.: A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology (New York, N.Y. 1943) 111(2), 492\u2013515 (1996)","DOI":"10.1053\/gast.1996.v111.pm8690216"},{"issue":"2","key":"8_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1177\/1933719112446082","volume":"20","author":"WJEP Lammers","year":"2013","unstructured":"Lammers, W.J.E.P.: The electrical activities of the uterus during pregnancy. Reprod. Sci. 20(2), 182\u2013189 (2013)","journal-title":"Reprod. Sci."},{"key":"8_CR8","doi-asserted-by":"crossref","unstructured":"Lammers, W.J.E.P., Stephen, B., Al-Sultan, M.A., Subramanya, S.B., Blanks, A.M.: The location of pacemakers in the uteri of pregnant guinea pigs and rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 309(11), R1439\u2013R1446 (2015)","DOI":"10.1152\/ajpregu.00187.2015"},{"key":"8_CR9","doi-asserted-by":"crossref","unstructured":"Lammers, W.J.E.P., et al.: Patterns of electrical propagation in the intact pregnant guinea pig uterus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294(3), R919\u2013R928 (2008)","DOI":"10.1152\/ajpregu.00704.2007"},{"issue":"7","key":"8_CR10","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1088\/0967-3334\/29\/7\/011","volume":"29","author":"C Rabotti","year":"2008","unstructured":"Rabotti, C., Mischi, M., van Laar, J.O.E.H., Oei, G.S., Bergmans, J.W.M.: Estimation of internal uterine pressure by joint amplitude and frequency analysis of electrohysterographic signals. Physiol. Meas. 29(7), 829\u2013841 (2008)","journal-title":"Physiol. Meas."},{"key":"8_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2021.103231","volume":"71","author":"J Xu","year":"2022","unstructured":"Xu, J., Chen, Z., Lou, H., Shen, G., Pumir, A.: Review on EHG signal analysis and its application in preterm diagnosis. Biomed. Signal Process. Control 71, 103231 (2022)","journal-title":"Biomed. Signal Process. Control"},{"issue":"2","key":"8_CR12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1152\/ajplegacy.1959.196.2.343","volume":"196","author":"CY Kao","year":"1959","unstructured":"Kao, C.Y.: Long-term observations of spontaneous electrical activity of the uterine smooth muscle. Am. J. Physiol. 196(2), 343\u2013350 (1959)","journal-title":"Am. J. Physiol."},{"issue":"4","key":"8_CR13","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0002-9378(85)90085-7","volume":"153","author":"A Verhoeff","year":"1985","unstructured":"Verhoeff, A., Garfield, R.E., Ramondt, J., Wallenburg, H.C.S.: Electrical and mechanical uterine activity and gap junctions in peripartal sheep. Am. J. Obstet. Gynecol. 153(4), 447\u2013454 (1985)","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"8_CR14","doi-asserted-by":"publisher","first-page":"R525","DOI":"10.1152\/ajpregu.00153.2009","volume":"297","author":"BF Mitchell","year":"2009","unstructured":"Mitchell, B.F., Taggart, M.J.: Are animal models relevant to key aspects of human parturition? Am. J. Phys. Regul. Integr. Comp. Physiol. 297(3), R525-545 (2009)","journal-title":"Am. J. Phys. Regul. Integr. Comp. Physiol."},{"key":"8_CR15","doi-asserted-by":"crossref","unstructured":"Malik, M., Roh, M., England, S.K.: Uterine contractions in rodent models and humans. Acta Physiologica 231(4), e13607-n\/a (2021)","DOI":"10.1111\/apha.13607"},{"key":"8_CR16","doi-asserted-by":"crossref","unstructured":"Jain, V., Saade, G.R., Garfield, R.E.: Structure and function of the myometrium. In: Advances in Organ Biology, vol. 8, Elsevier B.V, pp. 215\u2013246 (2000)","DOI":"10.1016\/S1569-2590(00)08009-5"},{"key":"8_CR17","doi-asserted-by":"crossref","unstructured":"Weiss, S., et al.: Three\u2010dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging. Anat. Record. Part A, Discoveries Mol. Cell. Evol. Biol. 288A(1), 84\u201390 (2006)","DOI":"10.1002\/ar.a.20274"},{"issue":"6","key":"8_CR18","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s11517-009-0433-4","volume":"47","author":"S Rihana","year":"2009","unstructured":"Rihana, S., Terrien, J., Germain, G., Marque, C.: Mathematical modeling of electrical activity of uterine muscle cells. Med. Biol. Eng. Compu. 47(6), 665\u2013675 (2009)","journal-title":"Med. Biol. Eng. Compu."},{"key":"8_CR19","doi-asserted-by":"crossref","unstructured":"Benson, A.P., Clayton, R.H., Holden, A.V., Kharche, S., Tong, W.C.: Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling. Philos. Trans. R. Soc. London Ser. A: Math. Phys. Eng. Sci. 364(1842), 1313\u20131327 (2006)","DOI":"10.1098\/rsta.2006.1772"},{"key":"8_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.compbiomed.2017.12.001","volume":"93","author":"M Yochum","year":"2018","unstructured":"Yochum, M., Lafor\u00eat, J., Marque, C.: Multi-scale and multi-physics model of the uterine smooth muscle with mechanotransduction. Comput. Biol. Med. 93, 17\u201330 (2018)","journal-title":"Comput. Biol. Med."},{"issue":"3","key":"8_CR21","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10237-015-0703-z","volume":"15","author":"B Sharifimajd","year":"2016","unstructured":"Sharifimajd, B., Thore, C.-J., St\u00e5lhand, J.: Simulating uterine contraction by using an electro-chemo-mechanical model. Biomech. Model. Mechanobiol. 15(3), 497\u2013510 (2016)","journal-title":"Biomech. Model. Mechanobiol."},{"key":"8_CR22","doi-asserted-by":"crossref","unstructured":"Means, S.A., Clark, A.R., Cheng, L.K.: Steady-state Approximations for Hodgkin-Huxley Cell Models: Towards Multi-scale Models of Uterine Smooth Muscle. Physiome (2023)","DOI":"10.36903\/physiome.24439204"},{"key":"8_CR23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.compbiomed.2016.08.001","volume":"77","author":"M Yochum","year":"2016","unstructured":"Yochum, M., Lafor\u00eat, J., Marque, C.: An electro-mechanical multiscale model of uterine pregnancy contraction. Comput. Biol. Med. 77, 182\u2013194 (2016)","journal-title":"Comput. Biol. Med."},{"key":"8_CR24","doi-asserted-by":"crossref","unstructured":"Zahran, S.: Finite Element Modeling of Electrical Activity in Human Uterine Tissue: Advances in Simulation Techniques. Cold Spring Harbor Laboratory (2024)","DOI":"10.1101\/2024.10.06.616865"},{"key":"8_CR25","doi-asserted-by":"crossref","unstructured":"Tong, W.-C., Choi, C.Y., Karche, S., Holden, A.V., Zhang, H., Taggart, M.J.: A computational model of the ionic currents, Ca.sup.2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle. PloS One 6(4), e18685 (2011)","DOI":"10.1371\/journal.pone.0018685"},{"key":"8_CR26","doi-asserted-by":"crossref","unstructured":"Mirams, G.R., et al.: Chaste: an open source C++ library for computational physiology and biology. PLoS Comput. Biol. 9(3), e1002970 (2013)","DOI":"10.1371\/journal.pcbi.1002970"},{"issue":"12","key":"8_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114034","volume":"9","author":"W-C Tong","year":"2014","unstructured":"Tong, W.-C., Tribe, R.M., Smith, R., Taggart, M.J.: Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor. PLoS ONE 9(12), e114034 (2014)","journal-title":"PLoS ONE"},{"issue":"9","key":"8_CR28","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.3390\/biomedicines12092126","volume":"12","author":"Q Li","year":"2024","unstructured":"Li, Q., Zhu, X., Chen, W.: Parallelization of three dimensional cardiac simulation on GPU. Biomedicines 12(9), 2126 (2024)","journal-title":"Biomedicines"},{"key":"8_CR29","doi-asserted-by":"crossref","unstructured":"Melton Carlton, E.J.R., Saldivar Julian, T.J.R.: Impulse velocity and conduction pathways in rat myometrium. Am. J. Physiol. 207(2), 279\u2013285 (1964)","DOI":"10.1152\/ajplegacy.1964.207.2.279"},{"issue":"4","key":"8_CR30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/j.1749-6632.1962.tb54120.x","volume":"96","author":"W Rall","year":"1962","unstructured":"Rall, W.: Theory of physiological properties of dendrites. Ann. N. Y. Acad. Sci. 96(4), 1071\u20131092 (1962)","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"8_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1152\/physrev.00018.2008","volume":"90","author":"S Wray","year":"2010","unstructured":"Wray, S., Burdyga, T.: Sarcoplasmic reticulum function in smooth muscle. Physiol. Rev. 90(1), 113\u2013178 (2010)","journal-title":"Physiol. Rev."},{"issue":"3","key":"8_CR32","doi-asserted-by":"publisher","first-page":"e0118443","DOI":"10.1371\/journal.pone.0118443","volume":"10","author":"J Xu","year":"2015","unstructured":"Xu, J., Menon, S.N., Singh, R., Garnier, N.B., Sinha, S., Pumir, A.: The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue. PLoS ONE 10(3), e0118443\u2013e0118443 (2015)","journal-title":"PLoS ONE"}],"container-title":["Lecture Notes in Computer Science","Digital Twin for Healthcare"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-07694-6_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:05:11Z","timestamp":1759169111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-07694-6_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"ISBN":["9783032076939","9783032076946"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-07694-6_8","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"30 September 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of Interests"}},{"value":"DT4H","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Workshop on Digital Twin for Healthcare","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Daejeon","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Korea (Republic of)","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2025","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"23 September 2025","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"23 September 2025","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"1","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"dt4h2025","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/digitaltwinforhealthcare.com\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}