{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T23:39:21Z","timestamp":1777246761477,"version":"3.51.4"},"publisher-location":"Cham","reference-count":20,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032183750","type":"print"},{"value":"9783032183767","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-3-032-18376-7_2","type":"book-chapter","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T23:01:05Z","timestamp":1777244465000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Sperm DNA Damage: When and Why It Does Not Add to the Evaluation of Male Factor Infertility"],"prefix":"10.1007","author":[{"given":"Mohamad Abou","family":"Chakra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Mima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Niederberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Ohlander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"4","key":"2_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.5534\/wjmh.200128","volume":"38","author":"A Agarwal","year":"2020","unstructured":"Agarwal A, Majzoub A, Baskaran S, Panner Selvam MK, Cho CL, Henkel R et al (2020) Sperm DNA fragmentation: a new guideline for clinicians. World J Mens Health 38(4):412\u2013471","journal-title":"World J Mens Health"},{"issue":"2","key":"2_CR2","first-page":"306","volume":"28","author":"SW Andrabi","year":"2024","unstructured":"Andrabi SW, Ara A, Saharan A, Jaffar M, Gugnani N, Esteves SC (2024) Sperm DNA fragmentation: causes, evaluation and management in male infertility. JBRA Assist Reprod 28(2):306\u2013319","journal-title":"JBRA Assist Reprod"},{"issue":"10","key":"2_CR3","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.3390\/cells11101711","volume":"11","author":"M Assidi","year":"2022","unstructured":"Assidi M (2022) Infertility in men: advances towards a comprehensive and integrative strategy for precision theranostics. Cells 11(10):1711","journal-title":"Cells"},{"issue":"2","key":"2_CR4","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/1008-682X.170441","volume":"18","author":"CL Cho","year":"2016","unstructured":"Cho CL, Esteves SC, Agarwal A (2016) Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation. Asian J Androl 18(2):186\u2013193","journal-title":"Asian J Androl"},{"issue":"3","key":"2_CR5","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.fertnstert.2017.06.018","volume":"108","author":"SC Esteves","year":"2017","unstructured":"Esteves SC, Roque M, Bradley CK, Garrido N (2017) Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis. Fertil Steril 108(3):456\u2013467.e1","journal-title":"Fertil Steril"},{"issue":"1","key":"2_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/andr.13540","volume":"13","author":"A Inversetti","year":"2025","unstructured":"Inversetti A, Bossi A, Cristodoro M, Larcher A, Busnelli A, Grande G et al (2025) Recurrent pregnancy loss: a male crucial factor-a systematic review and meta-analysis. Andrology 13(1):130\u2013145","journal-title":"Andrology"},{"issue":"3","key":"2_CR7","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.fertnstert.2021.04.003","volume":"116","author":"FT Lira Neto","year":"2021","unstructured":"Lira Neto FT, Roque M, Esteves SC (2021) Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis. Fertil Steril 116(3):696\u2013712","journal-title":"Fertil Steril"},{"issue":"Suppl 4","key":"2_CR8","doi-asserted-by":"publisher","first-page":"S649","DOI":"10.21037\/tau.2017.07.09","volume":"6","author":"A Majzoub","year":"2017","unstructured":"Majzoub A, Agarwal A, Esteves SC (2017) Antioxidants for elevated sperm DNA fragmentation: a mini review. Transl Androl Urol 6(Suppl 4):S649\u2013S653","journal-title":"Transl Androl Urol"},{"issue":"1","key":"2_CR9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.fertnstert.2019.03.003","volume":"112","author":"DB McQueen","year":"2019","unstructured":"McQueen DB, Zhang J, Robins JC (2019) Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril 112(1):54\u201360.e3","journal-title":"Fertil Steril"},{"issue":"2","key":"2_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.rbmo.2014.10.018","volume":"30","author":"A Osman","year":"2015","unstructured":"Osman A, Alsomait H, Seshadri S, El-Toukhy T, Khalaf Y (2015) The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis. Reprod Biomed Online 30(2):120\u2013127","journal-title":"Reprod Biomed Online"},{"issue":"10","key":"2_CR11","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s10815-019-01543-5","volume":"36","author":"A Parrella","year":"2019","unstructured":"Parrella A, Keating D, Cheung S, Xie P, Stewart JD, Rosenwaks Z et al (2019) A treatment approach for couples with disrupted sperm DNA integrity and recurrent ART failure. J Assist Reprod Genet 36(10):2057\u20132066","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"2_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/and.13885","volume":"53","author":"D Qiu","year":"2021","unstructured":"Qiu D, Shi Q, Pan L (2021) Efficacy of varicocelectomy for sperm DNA integrity improvement: a meta-analysis. Andrologia 53(1):e13885","journal-title":"Andrologia"},{"issue":"10","key":"2_CR13","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1093\/humrep\/des261","volume":"27","author":"L Robinson","year":"2012","unstructured":"Robinson L, Gallos ID, Conner SJ, Rajkhowa M, Miller D, Lewis S, Kirkman-Brown J, Coomarasamy A (2012) The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod 27(10):2908\u20132917","journal-title":"Hum Reprod"},{"issue":"3","key":"2_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/GCO.0000000000000946","volume":"36","author":"PN Schlegel","year":"2024","unstructured":"Schlegel PN (2024) Abstinence for sperm sample collection and ART outcome: an unsubstantiated myth. Curr Opin Obstet Gynecol 36(3):113\u2013117","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"1","key":"2_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/JU.0000000000001521","volume":"205","author":"PN Schlegel","year":"2021","unstructured":"Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ et al (2021) Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part I. J Urol 205(1):36\u201343","journal-title":"J Urol"},{"issue":"1","key":"2_CR16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4103\/1008-682X.182822","volume":"19","author":"L Simon","year":"2017","unstructured":"Simon L, Zini A, Dyachenko A, Ciampi A, Carrell DT (2017) A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome. Asian J Androl 19(1):80\u201390","journal-title":"Asian J Androl"},{"issue":"1","key":"2_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10815-014-0374-1","volume":"32","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Zhu L, Jiang H, Chen H, Chen Y, Dai Y (2015) Sperm DNA fragmentation index and pregnancy outcome after IVF. J Assist Reprod Genet 32(1):17\u201326","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"2_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/and.14275","volume":"54","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang W, Wu X, Liu G, Dai Y, Jiang H et al (2022) Effect of varicocele on sperm DNA damage: a systematic review and meta-analysis. Andrologia 54(1):e14275","journal-title":"Andrologia"},{"issue":"4","key":"2_CR19","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.fertnstert.2014.06.033","volume":"102","author":"J Zhao","year":"2014","unstructured":"Zhao J, Zhang Q, Wang Y, Li Y (2014) Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization\/intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril 102(4):998\u20131005.e8","journal-title":"Fertil Steril"},{"issue":"1","key":"2_CR20","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00345-024-05090-2","volume":"42","author":"I Ziouziou","year":"2024","unstructured":"Ziouziou I, Rambhatla A, Shah R, Agarwal A (2024) Sperm DNA fragmentation and infertility: a narrative review. World J Urol 42(1):408","journal-title":"World J Urol"}],"container-title":["Advances in Experimental Medicine and Biology","Genetic and Epigenetic Damage in Human Spermatozoa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-032-18376-7_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T23:01:06Z","timestamp":1777244466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-032-18376-7_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9783032183750","9783032183767"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-3-032-18376-7_2","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"1 April 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}